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POT1 protection of telomeres 1 [ Gallus gallus (chicken) ]

Gene ID: 404538, updated on 10-Oct-2024

Summary

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Symbol
POT1provided by CGNC
Full Name
protection of telomeres 1provided by CGNC
Primary source
CGNC:6635
See related
Ensembl:ENSGALG00010001194
Gene type
protein coding
RefSeq status
PROVISIONAL
Organism
Gallus gallus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs
human mouse all
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Genomic context

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See POT1 in Genome Data Viewer
Location:
chromosome: 1
Exon count:
23
Annotation release Status Assembly Chr Location
106 current bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2) 1 NC_052532.1 (21910987..21978247)
106 current bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2) 1 NC_052573.1 (22164539..22231670)

Chromosome 1 - NC_052532.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC121109516 Neighboring gene zinc finger protein 800 Neighboring gene translation initiation factor IF-2-like Neighboring gene glutamate metabotropic receptor 8 Neighboring gene uncharacterized LOC112533160 Neighboring gene G protein-coupled receptor 37

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Mutational analyses of a single-stranded telomeric DNA binding domain of fission yeast pot1: conflict with X-ray crystallographic structure. Torigoe H, et al. Biosci Biotechnol Biochem, 2007 Feb. PMID 17284852
  2. Vertebrate POT1 restricts G-overhang length and prevents activation of a telomeric DNA damage checkpoint but is dispensable for overhang protection. Churikov D, et al. Mol Cell Biol, 2006 Sep. PMID 16943437, Free PMC Article
  3. Cell cycle localization, dimerization, and binding domain architecture of the telomere protein cPot1. Wei C, et al. Mol Cell Biol, 2004 Mar. PMID 14966288, Free PMC Article
  4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
  5. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. an electrophoretic mobility shift assay and isothermal titration calorimetry analyses of the binding ability of the site-directed mutants indicated that only five amino acids significantly contributed to telomeric DNA recognition of Pot1
    Title: Mutational analyses of a single-stranded telomeric DNA binding domain of fission yeast pot1: conflict with X-ray crystallographic structure.
  2. These data indicate that vertebrate POT1 is required for telomere capping but that it functions quite differently from TRF2.
    Title: Vertebrate POT1 restricts G-overhang length and prevents activation of a telomeric DNA damage checkpoint but is dispensable for overhang protection.
  3. Endogenous chicken Pot1 is present at telomeres during periods of the cell cycle when t loops are thought to be present in DNA.
    Title: Cell cycle localization, dimerization, and binding domain architecture of the telomere protein cPot1.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables G-rich strand telomeric DNA binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables telomerase inhibitor activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in regulation of telomere maintenance via telomerase IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in telomere capping IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in chromosome, telomeric region IEA
Inferred from Electronic Annotation
more info
 PubMed 
part_of nuclear telomere cap complex IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Preferred Names
protection of telomeres protein 1
Names
POT1 protection of telomeres 1 homolog
POT1-like telomere end-binding protein
cPot1
protection of telomeres 1 homolog
single-strand telomeric DNA-binding protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_206992.1 → NP_996875.1  protection of telomeres protein 1

    See identical proteins and their annotated locations for NP_996875.1

    Status: PROVISIONAL

    Source sequence(s)
    AY555718
    UniProtKB/Swiss-Prot
    P62597
    UniProtKB/TrEMBL
    A0A8V0X4I9
    Conserved Domains (2) summary
    smart00976
    Location:155 → 285
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    cd04498
    Location:305 → 421
    hPOT1_OB2; hPOT1_OB2: A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats ...

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

  1. NC_052532.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

    Range
    21910987..21978247
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_025147065.3 → XP_025002833.2  protection of telomeres protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0X4I9, A0A8V0X9W7
    Related
    ENSGALP00010001310.1, ENSGALT00010002760.1
    Conserved Domains (3) summary
    smart00976
    Location:155 → 285
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    cd04498
    Location:305 → 421
    hPOT1_OB2; A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats ending with ...
    cd20374
    Location:485 → 773
    Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region

  2. XM_015280911.4 → XP_015136397.3  protection of telomeres protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0X4I9, A0A8V0X9W7
    Related
    ENSGALP00010001309.1, ENSGALT00010002759.1
    Conserved Domains (3) summary
    smart00976
    Location:155 → 285
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    cd04498
    Location:305 → 421
    hPOT1_OB2; A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats ending with ...
    cd20374
    Location:485 → 773
    Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region

  3. XM_025147062.3 → XP_025002830.2  protection of telomeres protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0X4I9, A0A8V0X9W7
    Conserved Domains (3) summary
    smart00976
    Location:155 → 285
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    cd04498
    Location:305 → 421
    hPOT1_OB2; A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats ending with ...
    cd20374
    Location:485 → 773
    Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region

  4. XM_015280913.4 → XP_015136399.3  protection of telomeres protein 1 isoform X1

    UniProtKB/TrEMBL
    A0A8V0X4I9, A0A8V0X9W7
    Conserved Domains (3) summary
    smart00976
    Location:155 → 285
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    cd04498
    Location:305 → 421
    hPOT1_OB2; A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats ending with ...
    cd20374
    Location:485 → 773
    Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region

  5. XM_040674038.2 → XP_040529972.1  protection of telomeres protein 1 isoform X2

    Conserved Domains (3) summary
    smart00976
    Location:6 → 105
    Telo_bind; Telomeric single stranded DNA binding POT1/CDC13
    cd04498
    Location:125 → 241
    hPOT1_OB2; A subfamily of OB folds similar to the second OB fold (OB2) of human protection of telomeres 1 protein (hPOT1). POT1 proteins bind to the single-stranded (ss) 3-prime ends of the telomere. hPOT1 binds specifically to ss telomeric DNA repeats ending with ...
    cd20374
    Location:305 → 593
    Pot1C; Protection Of Telomeres Protein 1 (POT1) C-terminal region

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

  1. NC_052573.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

    Range
    22164539..22231670
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_046906981.1 → XP_046762937.1  protection of telomeres protein 1 isoform X3

  2. XM_046906979.1 → XP_046762935.1  protection of telomeres protein 1 isoform X3

  3. XM_046906980.1 → XP_046762936.1  protection of telomeres protein 1 isoform X3

  4. XM_046906982.1 → XP_046762938.1  protection of telomeres protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P62597

  5. XM_046906983.1 → XP_046762939.1  protection of telomeres protein 1 isoform X1

    UniProtKB/Swiss-Prot
    P62597
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P62597.1 GenPept UniProtKB/Swiss-Prot:P62597

Gene LinkOut

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