PDE4B phosphodiesterase 4B [Gallus gallus (chicken)] - Gene

Summary

Symbol: PDE4Bprovided by CGNC
Full Name: phosphodiesterase 4Bprovided by CGNC
Primary source: CGNC:8425
See related: Ensembl:ENSGALG00010027081
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Gallus gallus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda; Coelurosauria; Aves; Neognathae; Galloanserae; Galliformes; Phasianidae; Phasianinae; Gallus
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 8

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
106	current	bGalGal1.mat.broiler.GRCg7b (GCF_016699485.2)	8	NC_052539.1 (28067173..28211201)
106	current	bGalGal1.pat.whiteleghornlayer.GRCg7w (GCF_016700215.2)	8	NC_052580.1 (28079254..28223228)

Chromosome 8 - NC_052539.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

According to microarray and qRT-PCR analyses, the nucleotide metabolism-related gene PDE4B was more highly expressed in the chicken stage X blastoderms than that of primordial germ cells, gonadal stromal cells and embryonic fibroblasts.
Title: Comparative metabolic pathway analysis with special reference to nucleotide metabolism-related genes in chicken primordial germ cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables 3',5'-cyclic-AMP phosphodiesterase activity	IEA Inferred from Electronic Annotation more info	PubMed
enables transmembrane transporter binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	IEA Inferred from Electronic Annotation more info	PubMed
located_in nucleus	IEA Inferred from Electronic Annotation more info	PubMed
located_in perinuclear region of cytoplasm	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: 3',5'-cyclic-AMP phosphodiesterase 4B; cAMP-specific 3',5'-cyclic phosphodiesterase 4B

Names: phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)

NP_001026462.1

EC 3.1.4.17

XP_015146515.2

EC 3.1.4.17

XP_015146516.2

EC 3.1.4.17

XP_015146517.2

EC 3.1.4.17

XP_015146518.2

EC 3.1.4.17

XP_040560625.1

EC 3.1.4.17

XP_040560626.1

EC 3.1.4.17

XP_046778823.1

EC 3.1.4.17

XP_046778824.1

EC 3.1.4.17

XP_046778825.1

EC 3.1.4.17

XP_046778826.1

EC 3.1.4.17

XP_046778827.1

EC 3.1.4.17

XP_046778828.1

EC 3.1.4.17

XP_046778829.1

EC 3.1.4.17

XP_046778830.1

EC 3.1.4.17

XP_046778831.1

EC 3.1.4.17

XP_046778833.1

EC 3.1.4.17

XP_046778834.1

EC 3.1.4.17

XP_046800477.1

EC 3.1.4.17

XP_046800478.1

EC 3.1.4.17

XP_046800480.1

EC 3.1.4.17

XP_046800481.1

EC 3.1.4.17

XP_046800482.1

EC 3.1.4.17

XP_046800483.1

EC 3.1.4.17

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001031291.2 → NP_001026462.1 3',5'-cyclic-AMP phosphodiesterase 4B

See identical proteins and their annotated locations for NP_001026462.1

Status: PROVISIONAL

Source sequence(s)

AJ720018

UniProtKB/TrEMBL

A0A8V1A1Z1, Q5ZKR6

Conserved Domains (1) summary

pfam00233
Location:232 → 473

PDEase_I; 3'5'-cyclic nucleotide phosphodiesterase

RefSeqs of Annotated Genomes: Gallus gallus Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Genomic

NC_052539.1 Reference bGalGal1.mat.broiler.GRCg7b Primary Assembly

Range

28067173..28211201

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_015291029.4 → XP_015146515.2 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1

UniProtKB/TrEMBL

A0A8V1A706

Conserved Domains (1) summary

cd00077
Location:405 → 587

HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
XM_046944521.1 → XP_046800477.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X1
XM_015291030.4 → XP_015146516.2 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X2

UniProtKB/TrEMBL

A0A8V1A706, A0A8V1ACF2

Related

ENSGALP00010039906.1, ENSGALT00010065640.1

Conserved Domains (1) summary

cd00077
Location:390 → 572

HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
XM_015291031.4 → XP_015146517.2 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X3

UniProtKB/TrEMBL

A0A8V1A706, A0A8V1AEG8

Related

ENSGALP00010039904.1, ENSGALT00010065638.1

Conserved Domains (1) summary

cd00077
Location:327 → 509

HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
XM_046944526.1 → XP_046800482.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X4
XM_040704691.2 → XP_040560625.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X4

UniProtKB/TrEMBL

A0A8V1A1Z1

Conserved Domains (1) summary

cd00077
Location:186 → 368

HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
XM_046944525.1 → XP_046800481.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X4

Related

ENSGALP00010039902.1, ENSGALT00010065636.1
XM_046944522.1 → XP_046800478.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X4
XM_046944527.1 → XP_046800483.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X4
XM_046944524.1 → XP_046800480.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X4

Related

ENSGALP00010039903.1, ENSGALT00010065637.1
XM_040704692.2 → XP_040560626.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X4

UniProtKB/TrEMBL

A0A8V1A1Z1

Conserved Domains (1) summary

cd00077
Location:186 → 368

HDc; Metal dependent phosphohydrolases with conserved 'HD' motif
XM_015291032.4 → XP_015146518.2 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X5

UniProtKB/TrEMBL

A0A8V1A9J7

Conserved Domains (1) summary

cd00077
Location:172 → 354

HDc; Metal dependent phosphohydrolases with conserved 'HD' motif

Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Genomic

NC_052580.1 Alternate bGalGal1.pat.whiteleghornlayer.GRCg7w

Range

28079254..28223228

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_046922867.1 → XP_046778823.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X6
XM_046922868.1 → XP_046778824.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X2

UniProtKB/TrEMBL

A0A8V1ACF2
XM_046922869.1 → XP_046778825.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X3

UniProtKB/TrEMBL

A0A8V1AEG8
XM_046922875.1 → XP_046778831.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X4
XM_046922872.1 → XP_046778828.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X4
XM_046922870.1 → XP_046778826.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X4
XM_046922874.1 → XP_046778830.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X4
XM_046922877.1 → XP_046778833.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X4
XM_046922873.1 → XP_046778829.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X4
XM_046922871.1 → XP_046778827.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X4
XM_046922878.1 → XP_046778834.1 cAMP-specific 3',5'-cyclic phosphodiesterase 4B isoform X5