CCN1 cellular communication network factor 1 [Bos taurus (domestic cattle)] - Gene

Summary

Official Symbol: CCN1provided by VGNC
Official Full Name: cellular communication network factor 1provided by VGNC
Primary source: VGNC:VGNC:50270
See related: BGD:BT15906; Ensembl:ENSBTAG00000009844
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Bos taurus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae; Bovinae; Bos
Also known as: GIG1; CYR61
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 3

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2023_09	current	ARS-UCD2.0 (GCF_002263795.3)	3	NC_037330.1 (58488393..58491302, complement)

Chromosome 3 - NC_037330.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_037330.1 Chromosome 3 Reference ARS-UCD2.0 Primary Assembly

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The increased expression of CYR61 in the Day 4 corpus lutum (CL) and its transient increase by prostaglandin F2alpha in Day 6, Day 10, and Day 16 CL indicate that CYR61 may play a role in regulating angiogenesis over the life span of the CL.
Title: A role for cysteine-rich 61 in the angiogenic switch during the estrous cycle in cows: regulation by prostaglandin F2alpha.
Mechanical regulation of the Cyr61 gene in smooth muscle cells
Title: Regulation of Cyr61 gene expression by mechanical stretch through multiple signaling pathways.
Together, these results indicate that Cyr61 is an important determinant of the genetic reprogramming that occurs in mechanically challenged cells.
Title: Cyr61 mediates the expression of VEGF, alphav-integrin, and alpha-actin genes through cytoskeletally based mechanotransduction mechanisms in bladder smooth muscle cells.

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General gene information

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Gene Ontology Provided by RefSeq

Function	Evidence Code	Pubs
enables protein binding	IEA Inferred from Electronic Annotation more info	PubMed

Process	Evidence Code	Pubs
involved_in signal transduction	IEA Inferred from Electronic Annotation more info	PubMed

Component	Evidence Code	Pubs
located_in extracellular region	IEA Inferred from Electronic Annotation more info	PubMed

General protein information

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Preferred Names: CCN family member 1

Names: cysteine rich angiogenic inducer 61; cysteine-rich heparin-binding protein 61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001034340.2 → NP_001029512.1 CCN family member 1 precursor

See identical proteins and their annotated locations for NP_001029512.1

Status: PROVISIONAL

Source sequence(s)

BC102934

UniProtKB/TrEMBL

A0A3Q1LRR3, Q3ZC35

Related

ENSBTAP00000012977.3, ENSBTAT00000012977.5

Conserved Domains (4) summary

smart00209
Location:233 → 273

TSP1; Thrombospondin type 1 repeats

smart00214
Location:100 → 159

VWC; von Willebrand factor (vWF) type C domain

pfam00219
Location:26 → 78

IGFBP; Insulin-like growth factor binding protein

cl21545
Location:294 → 376

GHB_like; Glycoprotein hormone beta chain homologues