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SPL sphingosine 1-phosphate lyase [ Leishmania major strain Friedlin ]

Gene ID: 5653780, updated on 30-Oct-2024

Summary

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Gene symbol
SPL
Gene description
sphingosine 1-phosphate lyase
Locus tag
LMJF_30_2350
Gene type
protein coding
RNA name
sphingosine 1-phosphate lyase
RefSeq status
PROVISIONAL
Organism
Leishmania major strain Friedlin (strain: Friedlin)
Lineage
Eukaryota; Euglenozoa; Kinetoplastida; Trypanosomatidae; Leishmaniinae; Leishmania
Orthologs
all
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Genomic context

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See SPL in Genome Data Viewer
Location:
chromosome: 30
Exon count:
1
Sequence:
Chromosome: 30; NC_007271.2 (906736..908349, complement)

Chromosome 30 - NC_007271.2Genomic Context describing neighboring genes Neighboring gene hypothetical protein Neighboring gene conserved zinc-finger protein Neighboring gene conserved zinc-finger protein Neighboring gene ADP-ribosylation factor-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_007271.2

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The genome of the kinetoplastid parasite, Leishmania major. Ivens AC, et al. Science, 2005 Jul 15. PMID 16020728, Free PMC Article
  2. Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania. Rogers MB, et al. Genome Res, 2011 Dec. PMID 22038252, Free PMC Article
  3. Manual GO annotation of predictive protein signatures: the InterPro approach to GO curation. Burge S, et al. Database (Oxford), 2012. PMID 22301074, Free PMC Article
  4. TreeGrafter: phylogenetic tree-based annotation of proteins with Gene Ontology terms and other annotations. Tang H, et al. Bioinformatics, 2019 Feb 1. PMID 30032202, Free PMC Article

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by RefSeq

Function Evidence Code Pubs
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
 PubMed 
enables sphinganine-1-phosphate aldolase activity IEA
Inferred from Electronic Annotation
more info
 PubMed 
Process Evidence Code Pubs
involved_in carboxylic acid metabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
involved_in sphingolipid catabolic process IEA
Inferred from Electronic Annotation
more info
 PubMed 
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
 PubMed 

General protein information

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Names
sphingosine 1-phosphate lyase
XP_001684840.1

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_007271.2 Reference assembly

    Range
    906736..908349 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_001684788.1 → XP_001684840.1  sphingosine 1-phosphate lyase [Leishmania major strain Friedlin]

    See identical proteins and their annotated locations for XP_001684840.1

    Status: PROVISIONAL

    UniProtKB/TrEMBL
    Q32Y75, Q4Q758
    Conserved Domains (1) summary
    cl18945
    Location:117 → 483
    AAT_I; Aspartate aminotransferase (AAT) superfamily (fold type I) of pyridoxal phosphate (PLP)-dependent enzymes. PLP combines with an alpha-amino acid to form a compound called a Schiff base or aldimine intermediate, which depending on the reaction, is the ...
Nucleotide Protein
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