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Rab27b RAB27B, member RAS oncogene family [ Mus musculus (house mouse) ]

Gene ID: 80718, updated on 14-Nov-2024

Summary

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Official Symbol
Rab27bprovided by MGI
Official Full Name
RAB27B, member RAS oncogene familyprovided by MGI
Primary source
MGI:MGI:1931295
See related
Ensembl:ENSMUSG00000024511 AllianceGenome:MGI:1931295
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
2310021G14Rik; B130064M09Rik
Summary
Enables GTP binding activity and GTPase activity. Predicted to be involved in several processes, including anterograde axonal protein transport; multivesicular body sorting pathway; and synaptic vesicle endocytosis. Located in Golgi apparatus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study platelet storage pool deficiency. Orthologous to human RAB27B (RAB27B, member RAS oncogene family). [provided by Alliance of Genome Resources, Nov 2024]
Expression
Biased expression in bladder adult (RPKM 15.6), stomach adult (RPKM 12.2) and 13 other tissues See more
Orthologs
human all
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Genomic context

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See Rab27b in Genome Data Viewer
Location:
18 E2; 18 43.89 cM
Exon count:
9
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (70112202..70274704, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (69979131..70141633, complement)

Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 36175 Neighboring gene coiled-coil domain containing 68 Neighboring gene STARR-seq mESC enhancer starr_44955 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_44957 Neighboring gene predicted gene, 41770 Neighboring gene STARR-seq mESC enhancer starr_44958 Neighboring gene STARR-seq mESC enhancer starr_44960 Neighboring gene dynactin associated protein Neighboring gene dynactin associated protein like 1

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Structure of the small GTPase Rab27b shows an unexpected swapped dimer. Chavas LM, et al. Acta Crystallogr D Biol Crystallogr, 2007 Jul. PMID 17582168
  2. Rab27b association with melanosomes: dominant negative mutants disrupt melanosomal movement. Chen Y, et al. J Invest Dermatol, 2002 Jun. PMID 12060386
  3. Functional Genome-wide Screen Identifies Pathways Restricting Central Nervous System Axonal Regeneration. Sekine Y, et al. Cell Rep, 2018 Apr 10. PMID 29642001, Free PMC Article
  4. Actions of Rab27B-GTPase on mammalian central excitatory synaptic transmission. Arias-Hervert ER, et al. Physiol Rep, 2020 May. PMID 32358861, Free PMC Article
  5. Transfer of miRNA in Macrophage-Derived Exosomes Induces Drug Resistance in Pancreatic Adenocarcinoma. Binenbaum Y, et al. Cancer Res, 2018 Sep 15. PMID 30042153

See all (69) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia.
    Title: RAB27B controls palmitoylation-dependent NRAS trafficking and signaling in myeloid leukemia.
  2. Deletion in chromosome 6 spanning alpha-synuclein and multimerin1 loci in the Rab27a/b double knockout mouse.
    Title: Deletion in chromosome 6 spanning alpha-synuclein and multimerin1 loci in the Rab27a/b double knockout mouse.
  3. NRF2 promotes urothelial cell response to bacterial infection by regulating reactive oxygen species and RAB27B expression.
    Title: NRF2 promotes urothelial cell response to bacterial infection by regulating reactive oxygen species and RAB27B expression.
  4. FOXO1-Mediated Downregulation of RAB27B Leads to Decreased Exosome Secretion in Diabetic Kidneys.
    Title: FOXO1-Mediated Downregulation of RAB27B Leads to Decreased Exosome Secretion in Diabetic Kidneys.
  5. Actions of Rab27B-GTPase on mammalian central excitatory synaptic transmission.
    Title: Actions of Rab27B-GTPase on mammalian central excitatory synaptic transmission.
  6. Inhibition of Rab27a and Rab27b Has Opposite Effects on the Regulation of Hair Cycle and Hair Growth.
    Title: Inhibition of Rab27a and Rab27b Has Opposite Effects on the Regulation of Hair Cycle and Hair Growth.
  7. A hypoxia-induced Rab pathway regulates embryo implantation by controlled trafficking of secretory granules.
    Title: A hypoxia-induced Rab pathway regulates embryo implantation by controlled trafficking of secretory granules.
  8. miR-34c-5p could increase its intracellular level by inhibiting exosome-mediated transfer via a positive feedback loop through RAB27B, a molecule that promotes exosome shedding.
    Title: miR-34c-5p promotes eradication of acute myeloid leukemia stem cells by inducing senescence through selective RAB27B targeting to inhibit exosome shedding.
  9. While RAB11a recruits its effector RAB11FIP3 and cytoskeletal motor Dynein, RAB27b mobilizes the effector MyRIP and motor Myosin VIIa to mediate bacterial expulsion.
    Title: Collaboration between Distinct Rab Small GTPase Trafficking Circuits Mediates Bacterial Clearance from the Bladder Epithelium.
  10. this study shows that Rab27a and Rab27b double-knockout mice that are deficient in exosome secretion have a chronic, low-grade inflammatory phenotype characterized by elevated inflammatory cytokines and myeloproliferation
    Title: Rab27-Dependent Exosome Production Inhibits Chronic Inflammation and Enables Acute Responses to Inflammatory Stimuli.
Submit: New GeneRIF Correction See all GeneRIFs (33)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables G protein activity IEA
Inferred from Electronic Annotation
more info
  
enables GDP binding ISO
Inferred from Sequence Orthology
more info
  
enables GDP binding ISS
Inferred from Sequence or Structural Similarity
more info
  
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTP binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables GTP binding ISO
Inferred from Sequence Orthology
more info
  
enables GTPase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables GTPase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables membrane scission GTPase motor activity IEA
Inferred from Electronic Annotation
more info
  
enables myosin V binding IEA
Inferred from Electronic Annotation
more info
  
enables myosin V binding ISO
Inferred from Sequence Orthology
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IEA
Inferred from Electronic Annotation
more info
  
enables protein domain specific binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in anterograde axonal protein transport ISO
Inferred from Sequence Orthology
more info
  
involved_in anterograde axonal protein transport ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in multivesicular body sorting pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in multivesicular body sorting pathway ISO
Inferred from Sequence Orthology
more info
  
involved_in positive regulation of exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in positive regulation of exocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in positive regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in regulation of exocytosis ISO
Inferred from Sequence Orthology
more info
  
involved_in synaptic vesicle endocytosis IEA
Inferred from Electronic Annotation
more info
  
involved_in synaptic vesicle endocytosis ISO
Inferred from Sequence Orthology
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in Golgi stack IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi stack ISO
Inferred from Sequence Orthology
more info
  
is_active_in apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
located_in apical plasma membrane ISO
Inferred from Sequence Orthology
more info
  
located_in axon cytoplasm IEA
Inferred from Electronic Annotation
more info
  
is_active_in exocytic vesicle IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in late endosome ISO
Inferred from Sequence Orthology
more info
  
located_in late endosome ISS
Inferred from Sequence or Structural Similarity
more info
  
is_active_in melanosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in melanosome IEA
Inferred from Electronic Annotation
more info
  
located_in melanosome ISO
Inferred from Sequence Orthology
more info
  
located_in multivesicular body membrane IEA
Inferred from Electronic Annotation
more info
  
located_in multivesicular body membrane ISO
Inferred from Sequence Orthology
more info
  
is_active_in secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in synaptic vesicle membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in synaptic vesicle membrane ISO
Inferred from Sequence Orthology
more info
  
located_in trans-Golgi network transport vesicle IEA
Inferred from Electronic Annotation
more info
  
located_in trans-Golgi network transport vesicle ISO
Inferred from Sequence Orthology
more info
  
located_in zymogen granule membrane IEA
Inferred from Electronic Annotation
more info
  
located_in zymogen granule membrane ISO
Inferred from Sequence Orthology
more info
  

General protein information

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Preferred Names
ras-related protein Rab-27B
NP_001076022.1
NP_001289727.1
NP_001289728.1
NP_085031.3
XP_006526427.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001082553.2 → NP_001076022.1  ras-related protein Rab-27B isoform 1

    See identical proteins and their annotated locations for NP_001076022.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate exon structure in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AC108433, AC110224, AK049854, BY127417, BY130221
    Consensus CDS
    CCDS29331.1
    UniProtKB/Swiss-Prot
    Q8CIX0, Q99P58
    UniProtKB/TrEMBL
    Q4VA90, Q549X4
    Related
    ENSMUSP00000114094.2, ENSMUST00000121693.8
    Conserved Domains (2) summary
    smart00175
    Location:10 → 184
    RAB; Rab subfamily of small GTPases
    cd04127
    Location:6 → 185
    Rab27A; Rab GTPase family 27a (Rab27a)

  2. NM_001302798.1 → NP_001289727.1  ras-related protein Rab-27B isoform 1

    See identical proteins and their annotated locations for NP_001289727.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) contains an alternate exon in the 5' UTR compared to variant 1. Variants 1, 2, and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AC108433, AC163398, AK049854, AK161136, AW455378, BY228140, BY721478
    Consensus CDS
    CCDS29331.1
    UniProtKB/Swiss-Prot
    Q8CIX0, Q99P58
    UniProtKB/TrEMBL
    Q4VA90, Q549X4
    Related
    ENSMUSP00000112807.2, ENSMUST00000117692.8
    Conserved Domains (2) summary
    smart00175
    Location:10 → 184
    RAB; Rab subfamily of small GTPases
    cd04127
    Location:6 → 185
    Rab27A; Rab GTPase family 27a (Rab27a)

  3. NM_001302799.1 → NP_001289728.1  ras-related protein Rab-27B isoform 2

    See identical proteins and their annotated locations for NP_001289728.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate splice donor, which results in the use of an alternate start codon and a frameshift in the 5' coding region compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC108433, AC163398, AK049854, AK161136, AW455378, BY228140, BY721478
    UniProtKB/TrEMBL
    Q05D38
    Conserved Domains (1) summary
    cl38936
    Location:15 → 120
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

  4. NM_030554.4 → NP_085031.3  ras-related protein Rab-27B isoform 1

    See identical proteins and their annotated locations for NP_085031.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2, and 3 encode the same protein (isoform 1).
    Source sequence(s)
    AC108433, AC163398, AK049854, AK161136, AW455378, BY228140, BY721478
    Consensus CDS
    CCDS29331.1
    UniProtKB/Swiss-Prot
    Q8CIX0, Q99P58
    UniProtKB/TrEMBL
    Q4VA90, Q549X4
    Related
    ENSMUSP00000068349.9, ENSMUST00000069749.9
    Conserved Domains (2) summary
    smart00175
    Location:10 → 184
    RAB; Rab subfamily of small GTPases
    cd04127
    Location:6 → 185
    Rab27A; Rab GTPase family 27a (Rab27a)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000084.7 Reference GRCm39 C57BL/6J

    Range
    70112202..70274704 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006526364.2 → XP_006526427.1  ras-related protein Rab-27B isoform X1

    See identical proteins and their annotated locations for XP_006526427.1

    UniProtKB/TrEMBL
    Q05D38
    Conserved Domains (1) summary
    cl38936
    Location:15 → 120
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q99P58.3 GenPept UniProtKB/Swiss-Prot:Q99P58

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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