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HTD2 hydroxyacyl-thioester dehydratase HTD2 [ Saccharomyces cerevisiae S288C ]

Gene ID: 856464, updated on 3-Nov-2024

Summary

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Official Symbol
HTD2
Official Full Name
hydroxyacyl-thioester dehydratase HTD2
Primary source
SGD:S000001109
Locus tag
YHR067W
See related
AllianceGenome:SGD:S000001109; FungiDB:YHR067W; VEuPathDB:YHR067W
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Saccharomyces cerevisiae S288C (strain: S288C)
Lineage
Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes; Saccharomycetales; Saccharomycetaceae; Saccharomyces
Also known as
RMD12
Summary
Enables (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity. Predicted to be involved in fatty acid metabolic process. Located in mitochondrion. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See HTD2 in Genome Data Viewer
Location:
chromosome: VIII
Exon count:
1
Sequence:
Chromosome: VIII; NC_001140.6 (230970..231812)

Chromosome VIII - NC_001140.6Genomic Context describing neighboring genes Neighboring gene RNA-dependent ATPase RRP3 Neighboring gene rRNA-binding ribosome biosynthesis protein Neighboring gene deoxyhypusine synthase Neighboring gene exosome non-catalytic core subunit RRP4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_001140.6

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Htd2p/Yhr067p is a yeast 3-hydroxyacyl-ACP dehydratase essential for mitochondrial function and morphology. Kastaniotis AJ, et al. Mol Microbiol, 2004 Sep. PMID 15387819
  2. Identification of the Leishmania major proteins LmjF07.0430, LmjF07.0440, and LmjF27.2440 as components of fatty acid synthase II. Gurvitz A. J Biomed Biotechnol, 2009. PMID 20145708, Free PMC Article
  3. Identification of a novel mycobacterial 3-hydroxyacyl-thioester dehydratase, HtdZ (Rv0130), by functional complementation in yeast. Gurvitz A, et al. J Bacteriol, 2008 Jun. PMID 18375556, Free PMC Article
  4. An ancient genetic link between vertebrate mitochondrial fatty acid synthesis and RNA processing. Autio KJ, et al. FASEB J, 2008 Feb. PMID 17898086
  5. Genetic dissection of the mitochondrial lipoylation pathway in yeast. Pietikäinen LP, et al. BMC Biol, 2021 Jan 25. PMID 33487163, Free PMC Article

See all (52) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Results suggest a crucial role of YHR067w in maintenance of mitochondrial respiratory competence and morphology in yeast.
    Title: Htd2p/Yhr067p is a yeast 3-hydroxyacyl-ACP dehydratase essential for mitochondrial function and morphology.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by SGD

Function Evidence Code Pubs
enables (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fatty acid biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in fatty acid metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
Component Evidence Code Pubs
located_in mitochondrion HDA PubMed 
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IDA
Inferred from Direct Assay
more info
 PubMed 
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
hydroxyacyl-thioester dehydratase HTD2
NP_011934.1
  • Mitochondrial 3-hydroxyacyl-thioester dehydratase; involved in fatty acid biosynthesis, required for respiratory growth and for normal mitochondrial morphology

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_001140.6 Reference assembly

    Range
    230970..231812
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001179197.1 → NP_011934.1  TPA: hydroxyacyl-thioester dehydratase HTD2 [Saccharomyces cerevisiae S288C]

    See identical proteins and their annotated locations for NP_011934.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    D3DL16, P38790
    UniProtKB/TrEMBL
    A6ZSX3, B3LSI5, B5VJZ5, C7GWS8, C8Z9K5, N1P9D5
    Conserved Domains (1) summary
    COG3777
    Location:4 → 280
    HTD2; Hydroxyacyl-ACP dehydratase HTD2, hotdog domain [Lipid transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P38790.1

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