Abstract
ComK, the master regulator of competence, is degraded by the general stress-related protease ClpCP but must be targeted to this protease by binding to the adapter protein MecA. The genome of Bacillus subtilis contains a paralog of mecA, ypbH. We show in the present study that YpbH, like MecA, binds ClpC and that its elimination or overproduction affects competence and sporulation.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Bacillus subtilis / genetics
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Bacillus subtilis / physiology*
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Bacterial Proteins / metabolism*
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Bacterial Proteins / physiology*
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Heat-Shock Proteins / metabolism*
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Spores, Bacterial / physiology
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Transcription, Genetic
Substances
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Bacterial Proteins
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ClpC protein, Bacteria
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Heat-Shock Proteins
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mecA protein, Bacillus subtilis