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Results (6,204 reactions)

Reaction identifier Equation Enzyme class Enzymes
RHEA:23252 [thioredoxin]-disulfide + a 2'-deoxyribonucleoside 5'-diphosphate + H2O = [thioredoxin]-dithiol + a ribonucleoside 5'-diphosphate 79,126 protein(s) (UniProtKB)
RHEA:23256 adenosylcob(III)yrinate a,c-diamide + 4 ATP + 4 H2O + 4 L-glutamine = adenosylcob(III)yrate + 4 ADP + 4 H+ + 4 L-glutamate + 4 phosphate
  • EC:6.3.5.10 adenosylcobyric acid synthase (glutamine-hydrolyzing)
RHEA:23268 guanidinoacetate + H2O = glycine + urea
RHEA:23304 atropine + H2O = H+ + tropate + tropine 1 protein(s) (UniProtKB)
RHEA:23336 2 H+ + H2O2 + 2 iodide = diiodine + 2 H2O 422 protein(s) (UniProtKB)
RHEA:23344 a purine D-ribonucleoside + H2O = a purine nucleobase + D-ribose 3 protein(s) (UniProtKB)
RHEA:23392 (n-1) H2O + RNA(n) = n a ribonucleoside 5'-phosphate + n H+
RHEA:23396 H2O + phloretin = 1,3,5-trihydroxybenzene + H+ + phloretate 2 protein(s) (UniProtKB)
RHEA:23412 H2O + N-acetylputrescine = acetate + putrescine 8 protein(s) (UniProtKB)
RHEA:23416 (2R)-O-phospho-3-sulfolactate + H2O = (2R)-3-sulfolactate + phosphate 8,402 protein(s) (UniProtKB)
RHEA:23420 α,α-trehalose 6-phosphate + H2O = α,α-trehalose + phosphate 16,109 protein(s) (UniProtKB)
RHEA:23432 (4S)-limonene + O2 + reduced [NADPH—hemoprotein reductase] = (4S)-perillyl alcohol + H+ + H2O + oxidized [NADPH—hemoprotein reductase] 3 protein(s) (UniProtKB)
RHEA:23436 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + H2O = 2,5,6-triamino-4-hydroxypyrimidine + D-ribose 5-phosphate
6,683 protein(s) (UniProtKB)
RHEA:23440 4-chlorobenzoate + H2O = 4-hydroxybenzoate + chloride + H+
RHEA:23456 (9Z,12Z)-octadecadienoate + AH2 + O2 = A + crepenynate + 2 H2O
RHEA:23460 benzyl cetraxate + H2O = benzyl alcohol + cetraxate + H+
RHEA:23476 1-(2-carboxyphenylamino)-1-deoxy-D-ribulose 5-phosphate + H+ = (1S,2R)-1-C-(indol-3-yl)glycerol 3-phosphate + CO2 + H2O 42,083 protein(s) (UniProtKB)
RHEA:23500 H2O + N6-propanoyl-L-lysyl-[protein] + NAD+ = 3''-O-propanoyl-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
7 protein(s) (UniProtKB)
RHEA:23504 adenosylcob(III)inamide + H2O = (R)-1-aminopropan-2-ol + adenosylcob(III)yrate 2 protein(s) (UniProtKB)
RHEA:23508 (7R)-7-(4-carboxybutanamido)cephalosporanate + H2O = (7R)-7-aminocephalosporanate + glutarate
  • EC:3.5.1.93 glutaryl-7-aminocephalosporanic-acid acylase
4 protein(s) (UniProtKB)
RHEA:23564 2 columbamine + O2 = 2 berberine + 2 H2O
RHEA:23576 (R)-N-methylcoclaurine + (S)-N-methylcoclaurine + O2 + reduced [NADPH—hemoprotein reductase] = berbamunine + H+ + 2 H2O + oxidized [NADPH—hemoprotein reductase] 1 protein(s) (UniProtKB)
RHEA:23596 H2O + 2 NAD+ + UDP-α-D-glucose = 3 H+ + 2 NADH + UDP-α-D-glucuronate 46,847 protein(s) (UniProtKB)
RHEA:23604 kievitone hydrate = H2O + kievitone 1 protein(s) (UniProtKB)
RHEA:23608 H+ + H2O + N-isopropylammelide = cyanurate + isopropylamine
  • EC:3.5.4.42 N-isopropylammelide isopropylaminohydrolase
1 protein(s) (UniProtKB)
RHEA:23640 1-aminocyclopropane-1-carboxylate + L-ascorbate + O2 = CO2 + ethene + 2 H2O + hydrogen cyanide + L-dehydroascorbate 1,149 protein(s) (UniProtKB)
RHEA:23644 lithocholate + O2 + reduced [NADPH—hemoprotein reductase] = H+ + H2O + hyodeoxycholate + oxidized [NADPH—hemoprotein reductase] 1 protein(s) (UniProtKB)
RHEA:23660 4-imidazolone-5-propanoate + H2O = N-formimidoyl-L-glutamate 19,038 protein(s) (UniProtKB)
RHEA:23680 a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-diphosphate + H+ + phosphate 59,487 protein(s) (UniProtKB)
RHEA:23684 (S)-cis-N-methylcanadine + O2 + reduced [NADPH—hemoprotein reductase] = allocryptopine + 2 H+ + H2O + oxidized [NADPH—hemoprotein reductase] 1 protein(s) (UniProtKB)
RHEA:23688 adenine + H+ + H2O = hypoxanthine + NH4+ 22,201 protein(s) (UniProtKB)
RHEA:23692 (R)-malate = H2O + maleate 4 protein(s) (UniProtKB)
RHEA:23696 myo-inositol + O2 = D-glucuronate + H+ + H2O 4,565 protein(s) (UniProtKB)
RHEA:23700 (6R)-5,10-methenyltetrahydrofolate + H2O = (6R)-10-formyltetrahydrofolate + H+
  • EC:3.5.4.9 methenyltetrahydrofolate cyclohydrolase
48,301 protein(s) (UniProtKB)
RHEA:23704 GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H+ + 2 phosphate 35,637 protein(s) (UniProtKB)
RHEA:23724 H2O + O2 + pyridoxal = 4-pyridoxate + H+ + H2O2
RHEA:23728 (5Z,8Z,11Z,14Z)-eicosatetraenoate + AH2 + 2 O2 = A + H2O + prostaglandin H2 569 protein(s) (UniProtKB)
RHEA:23736 5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H+ 16,315 protein(s) (UniProtKB)
RHEA:23780 H2O + oxaloacetate + propanoyl-CoA = (2S,3S)-2-methylcitrate + CoA + H+ 946 protein(s) (UniProtKB)
RHEA:23796 17-O-acetylnorajmaline + H2O = acetate + H+ + norajmaline 2 protein(s) (UniProtKB)
RHEA:23800 H2O + L-methionine = 2-oxobutanoate + methanethiol + NH4+ 2,309 protein(s) (UniProtKB)
RHEA:23820 GDP-α-D-mannose = GDP-4-dehydro-α-D-rhamnose + H2O 20,788 protein(s) (UniProtKB)
RHEA:23876 protoaphin aglucone = H2O + xanthoaphin
  • EC:4.2.1.73 protoaphin-aglucone dehydratase (cyclizing)
RHEA:23900 cis-stilbene oxide + H2O = (1R,2R)-hydrobenzoin 2,252 protein(s) (UniProtKB)
RHEA:23928 H2O + N8-acetylspermidine = acetate + spermidine 5 protein(s) (UniProtKB)
RHEA:23952 H2O + N-(2-phenylethyl)acetamide = 2-phenylethylamine + acetate
RHEA:23960 H+ + 2 H2O2 + hexadecanoate = CO2 + 3 H2O + pentadecanal
RHEA:23964 (E)-coniferaldehyde + H2O + NADP+ = (E)-ferulate + 2 H+ + NADPH 3 protein(s) (UniProtKB)
RHEA:23968 (E)-coniferaldehyde + H2O + NAD+ = (E)-ferulate + 2 H+ + NADH 3 protein(s) (UniProtKB)
RHEA:23980 cyclomaltodextrin + H2O = linear maltodextrin 6 protein(s) (UniProtKB)
RHEA:23988 (2S,6S)-2,6-diaminoheptanedioate + 2-oxoglutarate = (S)-2,3,4,5-tetrahydrodipicolinate + H+ + H2O + L-glutamate 6,860 protein(s) (UniProtKB)
RHEA:23996 a ribonucleoside 5'-triphosphate + H2O = a ribonucleoside 5'-phosphate + diphosphate + H+ 16,367 protein(s) (UniProtKB)
RHEA:24056 a myo-inositol phosphate + H2O = myo-inositol + phosphate 39,829 protein(s) (UniProtKB)
RHEA:24060 N-hydroxy-L-tyrosine + O2 + reduced [NADPH—hemoprotein reductase] = H+ + H2O + N,N-dihydroxy-L-tyrosine + oxidized [NADPH—hemoprotein reductase]
RHEA:24064 2 5-aminolevulinate = H+ + 2 H2O + porphobilinogen 39,637 protein(s) (UniProtKB)
RHEA:24068 cyclohexanone + H+ + NADPH + O2 = H2O + hexano-6-lactone + NADP+ 1 protein(s) (UniProtKB)
RHEA:24072 (13S)-hydroperoxy-(9Z,11E,15Z)-octadecatrienoate = 12,13-epoxy-(9Z,11E,15Z)-octadecatrienoate + H2O
RHEA:24084 all-trans-zeaxanthin + 2 H+ + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = all-trans-antheraxanthin + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
1 protein(s) (UniProtKB)
RHEA:24092 2 H+ + O2 + 2 sulochrin = 2 (2S)-bisdechlorogeodin + 2 H2O
  • EC:1.21.3.4 sulochrin oxidase [(+)-bisdechlorogeodin-forming]
RHEA:24100 diisopropyl fluorophosphate + H2O = diisopropyl phosphate + fluoride + 2 H+ 3 protein(s) (UniProtKB)
RHEA:24108 H2O + N-methyl-2-oxoglutaramate = 2-oxoglutarate + methylamine
RHEA:24116 (2E)-geranyl diphosphate + H2O = (S)-linalool + diphosphate 10 protein(s) (UniProtKB)
RHEA:24120 H+ + leukotriene E4 + NADPH + O2 = 20-hydroxy-leukotriene E4 + H2O + NADP+
RHEA:24144 3-hydroxy-3-(4-methylpent-3-en-1-yl)glutaryl-CoA = 3-(4-methylpent-3-en-1-yl)pent-2-enedioyl-CoA + H2O
RHEA:24148 D-glyceraldehyde 3-phosphate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] = (2R)-3-phosphoglycerate + 3 H+ + 2 reduced [2Fe-2S]-[ferredoxin]
  • EC:1.2.7.6 glyceraldehyde-3-phosphate dehydrogenase (ferredoxin)
1 protein(s) (UniProtKB)
RHEA:24164 [thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein] 41,848 protein(s) (UniProtKB)
RHEA:24192 (2R,4S)-2,4-diaminopentanoate + H2O + NADP+ = (2R)-2-amino-4-oxopentanoate + H+ + NADPH + NH4+ 1 protein(s) (UniProtKB)
RHEA:24196 (2R,4S)-2,4-diaminopentanoate + H2O + NAD+ = (2R)-2-amino-4-oxopentanoate + H+ + NADH + NH4+ 2 protein(s) (UniProtKB)
RHEA:24216 (2E,6E)-farnesal + H2O + NAD+ = (2E,6E)-farnesoate + 2 H+ + NADH 1,778 protein(s) (UniProtKB)
RHEA:24220 β-myrcene + O2 + reduced [NADPH—hemoprotein reductase] = (4R)-ipsdienol + H+ + H2O + oxidized [NADPH—hemoprotein reductase]
RHEA:24236 2 Fe(III)-[cytochrome c] + H2O + trimethylamine = 2 Fe(II)-[cytochrome c] + 3 H+ + trimethylamine N-oxide 1,355 protein(s) (UniProtKB)
RHEA:24252 H2O + P1,P4-bis(5'-adenosyl) tetraphosphate = 2 ADP + 2 H+
  • EC:3.6.1.41 bis(5'-nucleosyl)-tetraphosphatase (symmetrical)
17,440 protein(s) (UniProtKB)
RHEA:24272 H+ + Mg-protoporphyrin IX 13-monomethyl ester + NADPH + O2 = H2O + Mg-131-hydroxyprotoporphyrin 13-monomethyl ester + NADP+
RHEA:24296 (S)-dihydroorotate + H2O = H+ + N-carbamoyl-L-aspartate 29,699 protein(s) (UniProtKB)
RHEA:24308 25-hydroxycholesterol + O2 + reduced [NADPH—hemoprotein reductase] = 7α,25-dihydroxycholesterol + H+ + H2O + oxidized [NADPH—hemoprotein reductase] 3 protein(s) (UniProtKB)
RHEA:24320 an L-polyhomomethionine + O2 + reduced [NADPH—hemoprotein reductase] = an L-N-hydroxypolyhomomethionine + 2 H+ + H2O + oxidized [NADPH—hemoprotein reductase]
RHEA:24324 6-oxocineole + H+ + NADPH + O2 = 1,6,6-trimethyl-2,7-dioxabicyclo[3.2.2]nonan-3-one + H2O + NADP+
RHEA:24332 3α-hydroxy-3,5-dihydromonacolin L carboxylate = H2O + monacolin L carboxylate
RHEA:24364 H2O + N6-(2-hydroxyisobutanoyl)-L-lysyl-[protein] + NAD+ = 2''-O-(2-hydroxyisobutanoyl)-ADP-D-ribose + L-lysyl-[protein] + nicotinamide
1,147 protein(s) (UniProtKB)
RHEA:24372 H2O + N4-[6-(N-acetyl-α-D-glucosaminyl-1-phospho)-α-D-mannosyl-(1→2)-α-D-mannosyl-(glycan)]-L-asparaginyl-[protein] = H+ + N4-[6-phospho-α-D-mannosyl-(1→2)-α-D-mannosyl-(glycan)]-L-asparaginyl-[protein] + N-acetyl-D-glucosamine
  • EC:3.1.4.45 N-acetylglucosamine-1-phosphodiester alpha-N-acetylglucosaminidase
3 protein(s) (UniProtKB)
RHEA:24384 ATP + deamido-NAD+ + H2O + L-glutamine = AMP + diphosphate + H+ + L-glutamate + NAD+
  • EC:6.3.5.1 NAD(+) synthase (glutamine-hydrolyzing)
29,167 protein(s) (UniProtKB)
RHEA:24396 scytalone = 1,3,8-trihydroxynaphthalene + H2O 4 protein(s) (UniProtKB)
RHEA:24408 adenosine + H+ + H2O = inosine + NH4+ 42,441 protein(s) (UniProtKB)
RHEA:24420 H2O + N-terminal N-formyl-L-methionyl-[peptide] = formate + N-terminal L-methionyl-[peptide] 61,481 protein(s) (UniProtKB)
RHEA:24432 H2O + oxaloacetate = acetate + H+ + oxalate 1 protein(s) (UniProtKB)
RHEA:24440 ATP + H2O + phosphate(out) = ADP + H+ + 2 phosphate(in) 381 protein(s) (UniProtKB)
RHEA:24456 α-ribazole 5'-phosphate + H2O = α-ribazole + phosphate
  • EC:3.1.3.73 adenosylcobalamin/alpha-ribazole phosphatase
4 protein(s) (UniProtKB)
RHEA:24468 H+ + N,N-dimethylaniline + NADPH + O2 = H2O + N,N-dimethylaniline N-oxide + NADP+ 3,491 protein(s) (UniProtKB)
RHEA:24476 H2O + maleimide = H+ + maleamate
RHEA:24480 a 6-O-(β-D-xylopyranosyl)-β-D-glucopyranoside + H2O = a 6-O-(β-D-xylopyranosyl)-β-D-glucopyranose + an alcohol
RHEA:24488 H2O + isopentenyl diphosphate + 2 oxidized [2Fe-2S]-[ferredoxin] = (2E)-4-hydroxy-3-methylbut-2-enyl diphosphate + 2 H+ + 2 reduced [2Fe-2S]-[ferredoxin]
  • EC:1.17.7.4 4-hydroxy-3-methylbut-2-enyl diphosphate reductase
32,407 protein(s) (UniProtKB)
RHEA:24500 adenosine 5'-tetraphosphate + H2O = ATP + H+ + phosphate
RHEA:24512 L-serine + pyrazole = 3-(pyrazol-1-yl)-L-alanine + H2O 1 protein(s) (UniProtKB)
RHEA:24520 H2O + L-saccharopine + NAD+ = (S)-2-amino-6-oxohexanoate + H+ + L-glutamate + NADH
  • EC:1.5.1.9 saccharopine dehydrogenase (NAD(+), L-glutamate-forming)
5 protein(s) (UniProtKB)
RHEA:24524 20-oxo-5-O-β-D-mycaminosyltylonolide + 2 H+ + O2 + 2 reduced [2Fe-2S]-[ferredoxin] = 5-O-β-D-mycaminosyltylonolide + H2O + 2 oxidized [2Fe-2S]-[ferredoxin] 1 protein(s) (UniProtKB)
RHEA:24544 H2O + L-lysyl-[protein] + O2 = (S)-2-amino-6-oxohexanoyl-[protein] + H2O2 + NH4+ 6,330 protein(s) (UniProtKB)
RHEA:24548 an N6-acyl-L-lysine + H2O = a carboxylate + L-lysine
RHEA:24568 a 6-phospho-β-D-galactoside + H2O = an alcohol + D-galactose 6-phosphate 994 protein(s) (UniProtKB)
RHEA:24576 diphosphate + H2O = H+ + 2 phosphate 39,371 protein(s) (UniProtKB)
RHEA:24580 D-sorbitol 6-phosphate + H2O = D-sorbitol + phosphate 5 protein(s) (UniProtKB)