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These proteins act as key regulators of [[Circadian clock|clock gene]] expression through [[Transcription (biology)|transcriptional]] repression of [[BMAL1|Bmal1]]. Through their regulation of clock-controlled genes, the Rev-Erb proteins affect several physiological processes throughout the body, including [[Metabolism|metabolic]], [[Endocrine system|endocrine]], and [[Immune system|immune]] pathways.<ref>{{cite journal | vauthors = Scheiermann C, Kunisaki Y, Frenette PS | title = Circadian control of the immune system | journal = Nature Reviews. Immunology | volume = 13 | issue = 3 | pages = 190–8 | date = March 2013 | pmid = 23391992 | pmc = 4090048 | doi = 10.1038/nri3386 }}</ref><ref>{{cite journal | vauthors = Duez H, Staels B | title = Rev-erb-alpha: an integrator of circadian rhythms and metabolism | journal = Journal of Applied Physiology | volume = 107 | issue = 6 | pages = 1972–80 | date = December 2009 | pmid = 19696364 | pmc = 2966474 | doi = 10.1152/japplphysiol.00570.2009 }}</ref><ref>{{cite journal | vauthors = Wang S, Li F, Lin Y, Wu B | title = Targeting REV-ERBα for therapeutic purposes: promises and challenges | journal = Theranostics | volume = 10 | issue = 9 | pages = 4168–4182 | date = 2020 | pmid = 32226546 | pmc = 7086371 | doi = 10.7150/thno.43834 }}</ref>
These proteins act as key regulators of [[Circadian clock|clock gene]] expression through [[Transcription (biology)|transcriptional]] repression of [[BMAL1|Bmal1]]. Through their regulation of clock-controlled genes, the Rev-Erb proteins affect several physiological processes throughout the body, including [[Metabolism|metabolic]], [[Endocrine system|endocrine]], and [[Immune system|immune]] pathways.<ref>{{cite journal | vauthors = Scheiermann C, Kunisaki Y, Frenette PS | title = Circadian control of the immune system | journal = Nature Reviews. Immunology | volume = 13 | issue = 3 | pages = 190–8 | date = March 2013 | pmid = 23391992 | pmc = 4090048 | doi = 10.1038/nri3386 }}</ref><ref>{{cite journal | vauthors = Duez H, Staels B | title = Rev-erb-alpha: an integrator of circadian rhythms and metabolism | journal = Journal of Applied Physiology | volume = 107 | issue = 6 | pages = 1972–80 | date = December 2009 | pmid = 19696364 | pmc = 2966474 | doi = 10.1152/japplphysiol.00570.2009 }}</ref><ref>{{cite journal | vauthors = Wang S, Li F, Lin Y, Wu B | title = Targeting REV-ERBα for therapeutic purposes: promises and challenges | journal = Theranostics | volume = 10 | issue = 9 | pages = 4168–4182 | date = 2020 | pmid = 32226546 | pmc = 7086371 | doi = 10.7150/thno.43834 }}</ref>


In the NRNC classification scheme, Rev-Erb is nuclear receptor subfamily 1 group D (NR1D). The name "Rev-Erb" derived by truncation from "Rev-ERBA" (Rev-Erbα), which in turn was named because it was on the opposite strand of ERBA ([[THRA]]) oncogene. The paralogous Rev-Ernβ does not seem to have anything special on its reverse strand. Older sources may use "Rev-ERBA" as the family name.<ref>PMID 25066191</ref>
In the NRNC classification scheme, Rev-Erb is nuclear receptor subfamily 1 group D (NR1D). The name "Rev-Erb" derived by truncation from "Rev-ERBA" (Rev-Erbα), which in turn was named because it was on the opposite strand of ERBA ([[THRA]]) oncogene. The paralogous Rev-Erbβ does not seem to have anything special on its reverse strand. Older sources may use "Rev-ERBA" as the family name.<ref>PMID 25066191</ref>


== See also ==
== See also ==

Revision as of 00:07, 12 August 2022

Diagram showing how REV-ERB regulates circadian gene expression through the secondary loop of the circadian transcription/translation feedback loop (TTFL)
nuclear receptor subfamily 1, group D, member 1
Identifiers
SymbolNR1D1
Alt. symbolsear-1, hRev, Rev-ErbAalpha, THRA1
NCBI gene9572
HGNC7962
OMIM602408
RefSeqNM_021724
UniProtP20393
Other data
LocusChr. 17 q11.2
Search for
StructuresSwiss-model
DomainsInterPro
nuclear receptor subfamily 1, group D, member 2
Identifiers
SymbolNR1D2
Alt. symbolsBD73, RVR, EAR-1r, HZF2, Hs.37288
NCBI gene9975
HGNC7963
OMIM602304
RefSeqXM_001130839
UniProtQ14995
Other data
LocusChr. 3 p24.1
Search for
StructuresSwiss-model
DomainsInterPro

The Rev-Erb proteins are members of the nuclear receptor (NR) superfamily of intracellular transcription factors and key regulatory components of the circadian clock. There are two forms of the receptor, Rev-Erb alpha and Rev-Erb beta, which are each encoded by a separate gene (NR1D1 and NR1D2, respectively).[1][2]  

These proteins act as key regulators of clock gene expression through transcriptional repression of Bmal1. Through their regulation of clock-controlled genes, the Rev-Erb proteins affect several physiological processes throughout the body, including metabolic, endocrine, and immune pathways.[3][4][5]

In the NRNC classification scheme, Rev-Erb is nuclear receptor subfamily 1 group D (NR1D). The name "Rev-Erb" derived by truncation from "Rev-ERBA" (Rev-Erbα), which in turn was named because it was on the opposite strand of ERBA (THRA) oncogene. The paralogous Rev-Erbβ does not seem to have anything special on its reverse strand. Older sources may use "Rev-ERBA" as the family name.[6]

See also

References

  1. ^ Lazar MA, Jones KE, Chin WW (March 1990). "Isolation of a cDNA encoding human Rev-ErbA alpha: transcription from the noncoding DNA strand of a thyroid hormone receptor gene results in a related protein that does not bind thyroid hormone". DNA and Cell Biology. 9 (2): 77–83. doi:10.1089/dna.1990.9.77. PMID 1971514.
  2. ^ Dumas B, Harding HP, Choi HS, Lehmann KA, Chung M, Lazar MA, Moore DD (August 1994). "A new orphan member of the nuclear hormone receptor superfamily closely related to Rev-Erb". Molecular Endocrinology. 8 (8): 996–1005. doi:10.1210/mend.8.8.7997240. PMID 7997240.
  3. ^ Scheiermann C, Kunisaki Y, Frenette PS (March 2013). "Circadian control of the immune system". Nature Reviews. Immunology. 13 (3): 190–8. doi:10.1038/nri3386. PMC 4090048. PMID 23391992.
  4. ^ Duez H, Staels B (December 2009). "Rev-erb-alpha: an integrator of circadian rhythms and metabolism". Journal of Applied Physiology. 107 (6): 1972–80. doi:10.1152/japplphysiol.00570.2009. PMC 2966474. PMID 19696364.
  5. ^ Wang S, Li F, Lin Y, Wu B (2020). "Targeting REV-ERBα for therapeutic purposes: promises and challenges". Theranostics. 10 (9): 4168–4182. doi:10.7150/thno.43834. PMC 7086371. PMID 32226546.
  6. ^ PMID 25066191
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