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== Clinical significance ==
== Clinical significance ==


There appears to be a connection between KLF14 and [[type 2 diabetes]].<ref name="pmid20581827">{{cite journal | author = Voight BF, Scott LJ, Steinthorsdottir V, et al. | title = Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis | journal = Nat. Genet. | volume = 42 | issue = 7 | pages = 579–89 |date=July 2010 | pmid = 20581827 | pmc = 3080658 | doi = 10.1038/ng.609 }}</ref><ref name="pmid20886378">{{cite journal | author = Grarup N, Sparsø T, Hansen T | title = Physiologic characterization of type 2 diabetes-related loci | journal = Curr. Diab. Rep. | volume = 10 | issue = 6 | pages = 485–97 |date=December 2010 | pmid = 20886378 | pmc = 2955912 | doi = 10.1007/s11892-010-0154-y }}</ref>
There appears to be a connection between KLF14 and [[coronary artery disease]], [[hypercholesterolemia]] and [[type 2 diabetes]].<ref name="pmid20581827">{{cite journal | author = Voight BF, Scott LJ, Steinthorsdottir V, et al. | title = Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis | journal = Nat. Genet. | volume = 42 | issue = 7 | pages = 579–89 |date=July 2010 | pmid = 20581827 | pmc = 3080658 | doi = 10.1038/ng.609 }}</ref><ref name="pmid20886378">{{cite journal | author = Grarup N, Sparsø T, Hansen T | title = Physiologic characterization of type 2 diabetes-related loci | journal = Curr. Diab. Rep. | volume = 10 | issue = 6 | pages = 485–97 |date=December 2010 | pmid = 20886378 | pmc = 2955912 | doi = 10.1007/s11892-010-0154-y }}</ref>


==References==
==References==

Revision as of 09:41, 20 September 2014

Template:PBB Krüppel-like factor 14, also known as basic transcription element-binding protein 5 (BTEB5) is a protein that in humans is encoded by the KLF14 gene.[1] The corresponding Klf14 mouse gene is known as Sp6.[2]

Function

KLF14 is a member of the Krüppel-like factor family of transcription factors. It regulates the transcription of various genes, including TGFβRII (the type II receptor for TGFβ).[3] KLF14 is expressed in many tissues,[4] lacks introns, and is subject to parent-specific expression.[5]

KLF14 appears to be a master regulator of gene expression in adipose tissue.[6]

Protein structure

Like the other members of the KLF family, KLF14 has three zinc-finger domains near the C-terminus, all three of which are of the classical C2H2 type. In the human, they are at amino acids 195–219, 225–249, and 255–277.[7]

Human KLF14 is 323 amino acids in length, with a molecular weight of 33,124;[7] in the mouse its length is 325.[8]

Clinical significance

There appears to be a connection between KLF14 and coronary artery disease, hypercholesterolemia and type 2 diabetes.[9][10]

References

  1. ^ "Klf14 Kruppel-like factor 14 [Mus musculus] - Gene result".
  2. ^ "Sp6 trans-acting transcription factor 6 [Mus musculus] - Gene result".
  3. ^ Truty MJ, Lomberk G, Fernandez-Zapico ME, Urrutia R (March 2009). "Silencing of the transforming growth factor-beta (TGFbeta) receptor II by Kruppel-like factor 14 underscores the importance of a negative feedback mechanism in TGFbeta signaling". J. Biol. Chem. 284 (10): 6291–300. doi:10.1074/jbc.M807791200. PMC 2649086. PMID 19088080.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  4. ^ Swamynathan SK (April 2010). "Krüppel-like factors: three fingers in control". Hum. Genomics. 4 (4): 263–70. doi:10.1186/1479-7364-4-4-263. PMC 2975451. PMID 20511139.{{cite journal}}: CS1 maint: unflagged free DOI (link)
  5. ^ Parker-Katiraee L, Carson AR, Yamada T, Arnaud P, Feil R, Abu-Amero SN, Moore GE, Kaneda M, Perry GH, Stone AC, Lee C, Meguro-Horike M, Sasaki H, Kobayashi K, Nakabayashi K, Scherer SW (May 2007). "Identification of the imprinted KLF14 transcription factor undergoing human-specific accelerated evolution". PLoS Genet. 3 (5): e65. doi:10.1371/journal.pgen.0030065. PMC 1865561. PMID 17480121.{{cite journal}}: CS1 maint: multiple names: authors list (link) CS1 maint: unflagged free DOI (link)
  6. ^ the MuTHER, Consortium (May 15, 2011). "Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes". Nature Genetics. 43 (6): 561–4. doi:10.1038/ng.833. PMC 3192952. PMID 21572415. {{cite journal}}: Unknown parameter |coauthors= ignored (|author= suggested) (help)
  7. ^ a b "Krüppel-like factor 14". Human Protein Reference Database. Johns Hopkins University. Retrieved 2011-05-18.
  8. ^ Online Mendelian Inheritance in Man (OMIM): Krüppel-like factor 14 - 609393
  9. ^ Voight BF, Scott LJ, Steinthorsdottir V; et al. (July 2010). "Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis". Nat. Genet. 42 (7): 579–89. doi:10.1038/ng.609. PMC 3080658. PMID 20581827. {{cite journal}}: Explicit use of et al. in: |author= (help)CS1 maint: multiple names: authors list (link)
  10. ^ Grarup N, Sparsø T, Hansen T (December 2010). "Physiologic characterization of type 2 diabetes-related loci". Curr. Diab. Rep. 10 (6): 485–97. doi:10.1007/s11892-010-0154-y. PMC 2955912. PMID 20886378.{{cite journal}}: CS1 maint: multiple names: authors list (link)


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