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Angela Vincent

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Angela Vincent
FRS FMedSci
Born
Angela Carmen Vincent

1942 (age 81–82)[1]
Woking,[1] England
Alma materUniversity of London (MB BS)
University College London (MSc)
AwardsLeslie Oliver Oration
Websitewww.ndcn.ox.ac.uk/team/angela-vincent

Angela Vincent FRS FMedSci (born 1942)[1] is Emeritus professor at the University of Oxford and a Fellow of Somerville College, Oxford.[2][3][4]

Career and research

Angela Vincent (nee Molony) was born in 1942, the third child of (Sir) Joseph and Carmen Molony. After school at St Mary's Convent, Ascot, she studied medicine at King's College London and Westminster Hospital School of Medicine (now merged with Imperial College School of Medicine). After one year as a junior doctor at St Steven's and St Charles' hospitals in London, she obtained an MSc in Biochemistry at University College London. This led to three frustrating years trying to fractionate rat brain synaptosomes, until she was taken on by Ricardo Miledi FRS in the Biophysics Department to help with his work on acetylcholine receptors. Her medical background helped to establish a collaboration on myasthenia gravis with John Newsom-Davis (later FRS); this led to development of the Neuroimmunology Group that subsequently moved with Newsom-Davis to Oxford when he was appointed Action Research Professor of Neurology. After his retirement in 1998, Vincent took over the group until 2016. During this time she was Head of the Department of Clinical Neurology (2005-2008) at the University of Oxford, President of the International Society of Neuroimmunology, and an Associate Editor of Brain (2004-2013).[5] Her research group was located in the Weatherall Institute of Molecular Medicine at the John Radcliffe Hospital, working on a wide range of biological disciplines encompassing molecular biology, biochemistry, cellular immunology and intracellular neurophysiology. The group's research focused on autoimmune and genetic disorders of the neuromuscular junction, peripheral nerves and more recently the exciting field of central nervous system diseases. The principal autoimmune diseases studied were myasthenia gravis, the Lambert-Eaton myasthenic syndrome, limbic encephalitis, other types of autoimmune encephalitis and acquired neuromyotonia. Since 2016 she has been Emeritus Professor at Oxford University and Honorary Professor at UCL and she continues to work on neuromuscular disorders and advise young researchers. Her work in Oxford on brain disorders continues under Associate Professor Sarosh Irani and Dr Patrick Waters.

Her contributions have been mainly on the roles of antibodies directed against ion channels, proteins complexed to ion channels, such as LGI1, CASPR2 and Contactin-2, within neurons, glia and the nerve-muscle junction in the pathogenesis of above-mentioned diseases.

She has demonstrated that transfer of these antibodies across the placenta from the pregnant woman to the fetus in utero can cause developmental abnormalities.

She is a strong supporter of Freedom from Torture (formerly The Medical Foundation for Treatment of Torture Victims) and a Patron of British Pugwash (that brings together scientists and other concerned with international affairs and disarmament).

Awards and honours

In 2009, she presented the Leslie Oliver Oration at Queen's Hospital.[6] In 2009, she received the medal of the Association of British Neurologists and in 2017, the World Federation of Neurology Scientific Contributions to Neurology award. In 2015, she was awarded the British Neuroscience Association Award for Outstanding Contribution to Neuroscience.[7] In Cologne 2018, she was awarded with J Posner and J Dalmau, the International Prize for Translational Neuroscience of the Gertrud Reemtsma Foundation (formerly the Klaus Joachim Zülch Prize), and in Washington in 2019, the America Epilepsy Society Clinical Science Research Award (with J Dalmau).Retrieved June 26, 2021, from https://www.ndcn.ox.ac.uk/team/angela-vincent</ref> She received the Inaugural Distinguished Alumni Award, Imperial College, London, 2020.

In 2002, she was elected a Fellow of the Academy of Medical Sciences (FMedSci)[8] and in 2011, a Fellow of the Royal Society (FRS).[9]

References

  1. ^ a b c VINCENT. "VINCENT, Prof. Angela Carmen". Who's Who. Vol. 2017 (online Oxford University Press ed.). Oxford: A & C Black. {{cite encyclopedia}}: Unknown parameter |othernames= ignored (help) (Subscription or UK public library membership required.) (subscription required)
  2. ^ Angela Vincent – Neuroscience
  3. ^ WIMM
  4. ^ Hoch, Werner; McConville, John; Helms, Sigrun; Newsom-Davis, John; Melms, Arthur; Vincent, Angela (2001). "Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor antibodies". Nature Medicine. 7 (3): 365–368. doi:10.1038/85520. ISSN 1546-170X. PMID 11231638. S2CID 18641849. Closed access icon
  5. ^ "Angela Vincent".
  6. ^ "The Second Leslie Oliver Oration". Archived from the original on 31 July 2012. Retrieved 1 July 2010.
  7. ^ "Prizes awarded by the British Neuroscience Association | The British Neuroscience Association". www.bna.org.uk. Retrieved 29 April 2021.
  8. ^ The Academy of Medical Sciences, archived from the original on 6 July 2021, retrieved 6 July 2021
  9. ^ The Royal Society, archived from the original on 6 July 2021, retrieved 6 July 2021 {{citation}}: |archive-date= / |archive-url= timestamp mismatch; 24 October 2019 suggested (help)

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