Due to certificate problems please use a browser other than Chrome, Edge, or other Chromium-based browsers to visit Xenbase. Examples include Firefox and Safari. We hope to be able to fix this issue soon. Thank you.
Click on this message to dismiss it.
Click here to close
Hello! We notice that you are using Internet Explorer, which is not supported by Xenbase and may cause the site to display incorrectly.
We suggest using a current version of Chrome,
FireFox, or Safari.
Rouxs Arch Dev Biol
1990 Mar 01;1986:330-335. doi: 10.1007/BF00383771.
Show Gene links
Show Anatomy links
Mesodermal induction in early amphibian embryos by activin A (erythroid differentiation factor).
Asashima M
,
Nakano H
,
Shimada K
,
Kinoshita K
,
Ishii K
,
Shibai H
,
Ueno N
.
???displayArticle.abstract???
Recently the mesoderm-inducing effects of the transforming growth factor β (TGF-β) family of proteins have been widely examined. In an attemt to elucidate the functions of these proteins, porcine inhibin A and activin A (erythroid differentiation factor; EDF) were examined. Treatment of explants with activin A led to differentiation of mesodermal derivatives such as mesenchyme, notochord, blood cells and muscle, but inhibin A had a much lesser effect. The mesodermal differentiation induced by activin A was also comfirmed by analyses using a polyclonal antibody against muscle myosin. By indirect immunofluorescence analysis, the differentiation of muscle blocks was observed in the activin-A-treated explants, whereas no differentiation was observed in inhibin-A-treated and control explants. These findings confirm that this protein of the TGF-β family has mesoderm-inducing ability.
Asashima,
Inducing effects of the grey crescent region of early developmental stages of ambystoma mexicanum.
1980, Pubmed
Asashima,
Inducing effects of the grey crescent region of early developmental stages of ambystoma mexicanum.
1980,
Pubmed
Asashima,
Purification of mesodermal inducing substance and protein synthesis using this material.
1986,
Pubmed
Asashima,
Effects of inducers on inner and outer gastrula ectoderm layers of Xenopus laevis.
1983,
Pubmed
,
Xenbase
Eto,
Purification and characterization of erythroid differentiation factor (EDF) isolated from human leukemia cell line THP-1.
1987,
Pubmed
Geithe,
A vegetalizing inducing factor. Isolation and chemical properties.
1981,
Pubmed
Grunz,
A mesoderm-inducing factor from a Xenopus laevis cell line : Chemical properties and relation to the vegetalizing factor from chicken embryos.
1989,
Pubmed
,
Xenbase
Grunz,
Induction of mesodermal tissues by acidic and basic heparin binding growth factors.
1988,
Pubmed
,
Xenbase
Gurdon,
Activation of muscle-specific actin genes in Xenopus development by an induction between animal and vegetal cells of a blastula.
1985,
Pubmed
,
Xenbase
Kimelman,
The presence of fibroblast growth factor in the frog egg: its role as a natural mesoderm inducer.
1988,
Pubmed
,
Xenbase
Kimelman,
Synergistic induction of mesoderm by FGF and TGF-beta and the identification of an mRNA coding for FGF in the early Xenopus embryo.
1987,
Pubmed
,
Xenbase
Knöchel,
Mesoderm induction by transforming growth factor beta: medium conditioned by TGF-beta-treated ectoderm enhances the inducing activity.
1989,
Pubmed
,
Xenbase
Knöchel,
Mesoderm-inducing factors. Their possible relationship to heparin-binding growth factors and transforming growth factor-beta.
1987,
Pubmed
Ling,
Pituitary FSH is released by a heterodimer of the beta-subunits from the two forms of inhibin.
,
Pubmed
Mason,
Complementary DNA sequences of ovarian follicular fluid inhibin show precursor structure and homology with transforming growth factor-beta.
,
Pubmed
Massagué,
The TGF-beta family of growth and differentiation factors.
1987,
Pubmed
Mercola,
Platelet-derived growth factor A chain is maternally encoded in Xenopus embryos.
1988,
Pubmed
,
Xenbase
Murata,
Erythroid differentiation factor is encoded by the same mRNA as that of the inhibin beta A chain.
1988,
Pubmed
Rosa,
Mesoderm induction in amphibians: the role of TGF-beta 2-like factors.
1988,
Pubmed
,
Xenbase
Slack,
Mesoderm induction in early Xenopus embryos by heparin-binding growth factors.
,
Pubmed
,
Xenbase
Smith,
Purification, partial characterization and biological effects of the XTC mesoderm-inducing factor.
1988,
Pubmed
,
Xenbase
Smith,
A mesoderm-inducing factor is produced by Xenopus cell line.
1987,
Pubmed
,
Xenbase
Vale,
Purification and characterization of an FSH releasing protein from porcine ovarian follicular fluid.
,
Pubmed
Weeks,
A maternal mRNA localized to the vegetal hemisphere in Xenopus eggs codes for a growth factor related to TGF-beta.
1987,
Pubmed
,
Xenbase
