http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_08a27fb8ab6fca84a0db9e12ed4f112f
Outgoing Links
Predicate | Object |
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family-name | Guang Yang Yang |
name | Guang Yang |
given-name | Guang |
organization-name | Institute of Basic Medical Sciences Academy of Military Medical Sciences Beijing China Department of Cardiology, Shaanxi Provincial People’s Hospital, Xi’an, Shaanxi, China (mainland) State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Key Laboratory of Biopesticide and Chemical Biology of Education Ministry, Key Laboratory of Pathogenic Fungi, School of Life Sciences, Fujian Agriculture and Forestry University , Fuzhou, China All authors: Bing Center for Waldenström’s Macroglobulinemia, Dana-Farber Cancer Institute; and Harvard Medical School, Boston, MA. School of Physical Education, Chinese Center of Exercise Epidemiology, Northeast Normal University, Changchun, China Shanghai Key Laboratory of Magnetic Resonance East China Normal University Shanghai P.R. China Histocompatibility and Immunogenetics Laboratory Alberta Precision Laboratories Calgary Alberta Canada Authors' Affiliation: Department of Genitourinary Medical Oncology—Research, The University of Texas MD Anderson Cancer Center, Houston, Texas Jilin Provincial Key Laboratory on Molecular and Chemical Genetic, The Second Hospital of Jilin University, Changchun 130041, P.R. China Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, Jiangsu, 210046, China Wuqi Meteorological Bureau, Wuqi 717600, Shaanxi, China. Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopaedic Department of Tongji Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China; Shanghai Key Laboratory of Signaling and Disease Research, School of Life Sciences and Technology, Tongji University, Shanghai 200092, China Animal Experiment Center, West China Hospital, Sichuan University, Chengdu 610041, China The First Hospital of Hebei Medical University Shijiazhuang Hebei China College of Chemistry and Materials Science, Anhui Normal University, Wuhu, 241000, China Department of Ophthalmology, Beijing Jishuitan Hospital, Beijing, China. Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai 200062, China School of Nano-Technology and Nano-Bionics, University of Science and Technology of China, Hefei 230026, China; Key Laboratory of Multifunctional Nanomaterials and Smart Systems, Advanced Materials Division, Suzhou Institute of Nano-Tech and Nano-Bionics, Chinese Academy of Sciences, Suzhou 215123, China Department of Pediatrics, Division of Neonatology, Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania; and Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, P.R. China Department of Sports Medicine Beijing Jishuitan Hospital Beijing China State Key Laboratory of Offshore Oil Exploitation; CNOOC Research Institute, Beijing 100027, People’s Republic of China Department of Pediatrics, Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. i‐lab Vacuum Interconnected Nanotech Workstation (Nano‐X) Suzhou Institute of Nano‐Tech and Nano‐Bionics Chinese Academy of Sciences Suzhou 215123 P. R. China WestCHEM, School of Chemistry, Joseph Black Building, University of Glasgow, University Avenue, Glasgow G12 8QQ, United Kingdom Biosensor National Special Laboratory; College of Biomedical Engineering and Instrument Science; Cyrus Tang Centre for Sensor Materials and Applications; Zhejiang University; Hangzhou 310027, PR China Department of Ultrasound, First Affiliated Hospital of Jiamusi University Key Laboratory of Molecular Engineering of Polymers of Ministry of Education and Department of Macromolecular Science, Fudan University, Shanghai 200433, China, and Department of Chemical and Biological Engineering, Colorado State University, Fort Collins, Colorado 80523-1370, United States Department of Pathology, Laboratory of Medicine, Loma Linda University Medical Center, Loma Linda, CA, USA; Department of Genitourinary Medical Oncology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas Electronic Materials Research Laboratory, Key Laboratory of the Ministry of Education & International Center for Dielectric Research, Xi’an Jiaotong University, Xi’an, China 710049 Department of Biomedical Engineering Southern University of Science and Technology Shenzhen 518055 China Department of Orthopedics, Xiangya Hospital, Central South University, Changsha, China.; National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, China. Department of Radiology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, Hebei 050035, P.R. China Department of Neurology, Laboratory of Cerebrovascular Biology and Stroke, University of Minnesota Medical School, Minneapolis, Minnesota, U.S.A. 1Bing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Boston, Massachusetts.; 2Harvard Medical School, Boston, Massachusetts. School of Life Sciences Institutes of Brain Science and State Key Laboratory of Medical Neurobiology Fudan University Shanghai China Department of Head and Neck Radiotherapy Ward 1 Shandong Cancer Hospital and Institute, Shandong First Medical University & Shandong Academy of Medical Sciences Jinan Shandong China Department of Thoracic Surgery Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Lieber Institute for Brain Development, Baltimore, MD 21205; Laboratory of Cerebrovascular Biology and Stroke, Departments of Neurology and Department of Orthopaedic, the 2nd Affiliated Hospital, Medicine College of Zhejiang University, Hangzhou 310000, Zhejiang, China. [email protected] Stanford Cardiovascular Institute Stanford University Stanford CA; Veterans Affairs Palo Alto Health Care System Palo Alto CA Department of Nephrology, Medical Faculty, Heinrich-Heine University Düsseldorf, Düsseldorf, Germany. Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development (CNPD3), University of Florida, Gainesville, Florida 32610, United States From the Department of Geriatrics, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, China (G.Y., Z.T., L.P., J.L., J.C., S.H.); Hubei Provincial Academy of Traditional Chinese Medicine, Wuhan, China (G.Y., Z.T., L.P., J.L., J.C., S.H.) Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China Key Laboratory of Pathogenic Fungi and Mycotoxins of Fujian Province Key Laboratory of Biopesticide and Chemical Biology of Education Ministry School of Life Sciences Fujian Agriculture and Forestry University Fuzhou 350002 China Royal Brompton Hospital, Imperial College London and Cardiovascular Research Centre, National Heart Shanghai Institute for Advanced Immunochemical Studies ShanghaiTech University Shanghai China School of Chemistry and Materials Science, Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou 310024, China Department of Interventional Radiology, The Fourth Hospital of Hebei Medical University, Shijiangzhuang, Hebei 050011, P.R. China Department of Medical Affairs, Eye & Ent Hospital of Fudan University, Shanghai, People’s Republic of China Department of Thoracic Surgery Tangdu Hospital the Forth Military Medical University Xi'an China Department of Gastroenterology, South China Hospital, Medical School, Shenzhen University, Shenzhen, China Natural Products Engineering Technology Research Center, Dalian Medical University No. 9 Western Section, Lvshun South Street Dalian 116044 People's Republic of China Division of Vascular Biology, La Jolla Institute for Molecular Medicine, San Diego, California Bing Center for Waldenström Macroglobulinemia Dana‐Farber Cancer Institute Boston Massachusetts College of Chemistry Zhengzhou University Zhengzhou 450001 China Experimental Animal Center West China Hospital, Sichuan University Chengdu China Departments of Assay Methodology Development, Gene Expression and Protein Biochemistry, Computational, Analytical and Structural Sciences, and Medicinal Chemistry, GlaxoSmithKline Pharmaceuticals, 709 Swedeland Road, King of Prussia, Pennsylvania 19406 Department of Gerontology, the First Affiliated Hospital of Shandong First Medical University, Jinan, China. Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopaedic Department of Tongji Hospital, Shanghai Key Laboratory of Signaling and Disease Research, the School of Life Sciences and Technology, Tongji University, Shanghai 200092, China Department of Nephrology, Medical Faculty, University Hospital Düsseldorf, Heinrich-Heine-University Düsseldorf, Düsseldorf, Germany; and Tianjin Institute of Physical Education School of Martial Arts and Traditional National Sports Tianjin China College of Energy and Environmental Engineering, Hebei University of Engineering, Handan 056038, Hebei Province, P. R. China Department of Nutrition and Food Safety, College of Public Health, Dalian Medical University, Dalian, Liaoning, China Department of Parasitology, School of Medicine Jinan University Guangzhou Guangdong Province China Company 5 of Student Brigade, Second Military Medical University, Shanghai, China Department of Cardiology, Shaanxi Provincial People's Hospital, Xi’an, China Department of Laboratory Medicine and Pathology Mayo Clinic Rochester Minnesota USA Shanghai Key Laboratory of Magnetic Resonance Department of Physics East China Normal University 3663 North Zhong‐Shan Road 200062 Shanghai China Group of Peptides and Natural Products Research, School of Pharmaceutical Sciences Southern Medical University Guangzhou China Section of Infectious Diseases, Yale University School of Medicine, 300 Cedar Street, New Haven, CT 06510, USA. China Water Resources Beifang Investigation, Design and Research Co., Ltd., Tianjin 300222, China Co-Innovation Center of Jiangsu Marine Bio-Industry Technology, Jiangsu Ocean University, Lianyungang 222005, China; Jiangsu Key Laboratory of Marine Bioresources and Environment/Jiangsu Key Laboratory of Marine Biotechnology, Jiangsu Ocean University, Lianyungang 222005, China School of Life and Environmental Sciences Charles Perkins Centre The University of Sydney Sydney NSW Australia Roche Innovation Center Shanghai, ‡Roche Innovation Center Basel, §Medicinal Chemistry, ∥Chemical Biology, ⊥Pharmaceutical Sciences, #Discovery Virology, Roche Pharma Research and Early Development, Bldg 5, 720 Cailun Road, Shanghai 201203, China Department of Pediatrics, Yantaishan Hospital, Yantai, China; Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Nangang District, Harbin, Heilongjiang Province, 150001, People's Republic of China; Institute of Brain Science, Harbin Medical University, Nangang District, Harbin, Heilongjiang Province, 150001, People's Republic of China Institute of Disease Control and Prevention, Academy of Military Medical Sciences, Beijing, China Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University Chengdu 610031 P. R. China The State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai 200433, P. R. China State Key Laboratory of Continental Tectonic and Dynamics, Institute of Geology, Chinese Academy of Geological Sciences, Beijing 100037, China.; Guangdong Zhuhai Engineering Investigation Institute, Zhuhai 519000, China. Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 393 Middle Huaxia Road, Shanghai 201210, China Department of Public Health and Preventive Medicine, Jinan University, Guangzhou, China Hepatic Surgery Center, Tongji Hospital, Tongji Medical College , Huazhong University of Science and Technology , Wuhan City 430030, Hubei Province , P.R. China Qingdao University of Technology Communication and Electronic Engineering Institute, , Shandong 266033, China [email protected] Department of Chemical and Biomedical Engineering, Florida A&M University−Florida State University College of Engineering, Tallahassee, Florida 32310, United States Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an, China Department of Applied Chemistry; Zhejiang University of Technology; Hangzhou 310032; China Department of Cardiology, Shaanxi Provincial People’s Hospital Department of Otolaryngology Head and Neck Surgery, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, No. 600, Yishan Road, Xuhui District, Shanghai 200233, China Shanghai Institute for Advanced Immunochemical Studies ShanghaiTech University Shanghai 201210 P. R. China; Velox Pharmaceuticals Changzhou 213000 P. R. China Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China.; Shanghai Research Institute of Acupuncture and Meridian, Shanghai, China. College of Chemistry Chemical Engineering and Materials Science Key Laboratory of Molecular and Nano Probes Ministry of Education Collaborative Innovation Center of Functionalized Probes for, Chemical Imaging in Universities of Shandong Institutes of Biomedical Sciences Shandong Normal University Jinan 250014 P. R. China Roche Innovation Center Shanghai, ‡Medicinal Chemistry, §Chemical Biology, ∥Pharmaceutical Sciences, and ⊥Discovery Virology, Roche Pharma Research and Early Development, 720 Cailun Road, Shanghai, 201203 China Department of Orthopaedic Surgery Center for Cellular and Molecular Engineering University of Pittsburgh School of Medicine Pittsburgh Pennsylvania Beijing Institute of Basic Medical Sciences 27 Taiping Road Beijing 100850 P. R. China National Engineering Research Center for Nano-Medicine, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, South China Agricultural University, Guangzhou 510642, China; Guangdong Technology Research Center for Traditional Chinese Veterinary Medicine and Natural Medicine, South China Agricultural University, Guangzhou 510642, China Institute of Neuroscience State Key Laboratory of Neuroscience Center for Excellence in Brain Science and Intelligence Technology Chinese Academy of Sciences Shanghai China; University of Chinese Academy of Sciences Beijing China Department of Oncology BenQ Medical Center Nanjing Medical University Nanjing 210029 P. R. China Department of Food Nutrition and Safety, Dalian Medical University, No. 9W. Lushun South Road, Dalian 116044, China Department of Pediatrics Chinese PLA General Hospital Beijing China Key Laboratory of Spine and Spinal Cord Injury Repair and Regeneration of Ministry of Education, Orthopaedic Department of Tongji Hospital, Shanghai Key Laboratory of Signaling and Disease Research, the School of Life Sciences and Technology, Tongji University, Shanghai, China Key Laboratory for Thermal Science and Power Engineering of Ministry of Education Department of Engineering Mechanics Tsinghua University Beijing 100084 China School of Physical Education, Northeast Normal University, Changchun, China Thermo Fisher Scientific Inc. Shanghai 201210 China College of Medicine, Southwest Jiaotong University, Chengdu, Sichuan 610031, P. R. China Department of Pediatrics, Chinese PLA General Hospital, Beijing, P.R. China University of Alabama at Birmingham, Birmingham, Alabama 35233, United States Department of Anesthesiology Columbia University Medical Center New York New York USA Key Laboratory of Advanced Technologies of Materials; Ministry of Education; School of Materials Science and Engineering; Southwest Jiaotong University; Chengdu 610031 P. R. China Department of Biochemistry and Institute for Enzyme Research, University of Wisconsin, 1710 University Avenue, Madison, Wisconsin 53705, and Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742 Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China Steven P. Treon, Joshua Gustine, Kirsten Meid, Guang Yang, Lian Xu, Xia Liu, Maria Demos, Amanda Kofides, Nicholas Tsakmaklis, Jiaji G. Chen, Manit Munshi, Gloria Chan, Toni Dubeau, Zachary R. Hunter, and Jorge J. Castillo, Dana-Farber Cancer Institute; Steven P. Treon, Guang Yang, Xia Liu, Noopur Raje, Andrew Yee, Elizabeth O’Donnell, Zachary R. Hunter, and Jorge J. Castillo, Harvard Medical School; and Noopur Raje, Andrew Yee, and Elizabeth O’Donnell, Massachusetts General Hospital, Boston, MA. Neuroscience Research Centre, Cardiovascular and Cell Sciences Institute St. George's, University of London London United Kingdom Department of Geriatric Endocrinology, Chinese PLA General Hospital, Beijing, China. Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics−Huazhong University of Science and Technology, Wuhan, Hubei 430074, China; MoE Key Laboratory for Biomedical Photonics, Collaborative Innovation Center for Biomedical Engineering, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China State Key Laboratory of Oncology in South China, Department of Imaging and Interventional Radiology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong, 510060, P. R. China Institute of Low-dimensional Materials Genome Initiative, College of Chemistry and Environmental Engineering, Shenzhen University, Shenzhen 518060, China College of Physical Science and Technology, Yangzhou University, Yangzhou 225002, China Department of Urology Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, P.R. China Department of Electronic and Information Engineering Hong Kong Polytechnic University Hong Hum Kowloon Hong Kong SAR China; School of Science Wuhan Institute of Technology Wuhan Hubei 430073 China The Shenzhen Key Laboratory of Health Sciences and Technology Tsinghua Shenzhen International Graduate School, and Tsinghua‐Berkeley Shenzhen Institute (TBSI) Tsinghua University Shenzhen China Assistant Professor of Anesthesiology, Department of Anesthesiology, New York University Medical Center, New York, New York. 3Department of Pathogen Biology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.; 4Guangzhou Key Laboratory of Environmental Exposure and Health, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou, Guangdong, China. National Engineering Research Center for Nano-Medicine, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan, 430074, China Department of Epidemiology School of Medicine Jinan University Guangzhou China School of Food and Biological Engineering, Hefei University of Technology, Hefei 230009, China School of Life Sciences Institute of Brain Science and State Key Laboratory of Medical Neurobiology Fudan University Shanghai China Division of Neonatology, Children's Hospital of Philadelphia, and School of Electrical and Electronic Engineering Nanyang Technological University 50 Nanyang Ave. Singapore 639798 Singapore Shanghai Institute for Advanced Immunochemical Studies (SIAIS) ShanghaiTech University Shanghai 201210 P. R. China School of Materials Science and Engineering, Nanyang Technological University, 50 Nanyang Avenue, 639798, Singapore Janssen R&D China, 4560 Jinke Road, Shanghai 201210, China Department of Pathogen Biology, School of Medicine, Jinan University, Guangzhou, People’s Republic of China Department of Biomedical Engineering, College of Life Science & Technology, Huazhong University of Science and Technology, Wuhan 430074, China; National Engineering Research Center for Nano-Medicine, Huazhong University of Science & Technology, Wuhan 430074, China Electronic Materials Research Laboratory; Key Laboratory of the Ministry of Education & International Center for Dielectric Research; Xi'an Jiaotong University; Xi'an 710049 China Bing Center for Waldenström's Macroglobulinemia Dana‐Farber Cancer Institute Boston MA USA Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China; Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, Shandong, China. Department of Cardiac Intensive Care Unit The First Affiliated Hospital of Dalian Medical University Dalian China Operating Room of Anesthesia Surgery Center, West China Hospital, Sichuan University, Chengdu 610041, China Pathology Department, Hongqi Hospital of Mudanjiang Medical University, Mudanjiang 157011, P.R. China Department of Biochemistry and Molecular Biology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong Province, People's Republic of China. Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology , Wuhan, P.R. China Tissue Engineering and Biomaterials Laboratory, Fischell Department of Bioengineering, A. James Clark School of Engineering, University of Maryland, College Park, Maryland, USA. School of Electrical and Electronic Engineering, Nanyang Technological University, 639798 Singapore Department of Burn and Plastic Surgery Department of Wound Repair Shenzhen Institute of Translational Medicine The First Affiliated Hospital of Shenzhen University Health Science Center Shenzhen Second People's Hospital Shenzhen China State Key Laboratory of Superhard Materials, Changchun 130023, China. From the Departments of Geriatric Neurology (N.X., H.X., Q.S.) and General Medicine (G.Y., W.Z.), Xiangya Hospital, Central South University; and the National Clinical Research Center for Geriatric Disorders (N.X., H.X., Q.S.), Changsha, China. Washington Univ. in St. Louis, United States. Department of Gynecology, First Affiliated Hospital of Jiamusi University, Jiamusi Department of Biomedical Engineering; College of Life Science and Technology; Huazhong University of Science and Technology; Wuhan 430074, China; National Engineering Research Center for Nano-Medicine Department of Electrical and Computer Engineering, National University of Singapore, 117576 Singapore The State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science; Fudan University; Shanghai; China Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074 People’s Republic of China Key Laboratory of Advanced Technologies of Materials; Ministry of Education, and School of Materials Science and Engineering; Southwest Jiaotong University; Chengdu; P. R. China Department of Biomedical Engineering Huazhong University of Science & Technology Wuhan 430074 China Department of Neurosurgery The First Affiliated Hospital of Harbin Medical University Harbin 150001 China Department of Pediatrics, General Hospital of PL A, Beijing 100853, China. Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, China College of Materials and Metallurgy, Guizhou University, Guiyang 550025, China Department of Biomedical Engineering Pennsylvania State University University Park PA 16802 USA Vaxin, Inc.,1 Jiangsu Key Laboratory for Biodiversity and Biotechnology, Nanjing Normal University, 1 Wenyuan Road, Nanjing 210023, China Department of Medical Oncology, Dana-Farber Cancer Institute; Department of Medicine, Brigham and Women's Hospital, and College of the Ecology and Environment, Xinjiang University, Urumqi 830017, China; Key Laboratory of Oasis Ecology of Education Ministry, Xinjiang University, Urumqi 830046, China Department of Burn and Plastic Surgery, Institute Translational Medicine, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People's Hospital, Shenzhen 518035, China Department of Neurosurgery; The First Affiliated Hospital of Harbin Medical University; Harbin Heilongjiang Province China; Institute of Brain Science; Harbin Medical University; Harbin Heilongjiang Province China Department of Parasitology, School of Medicine, Jinan University, Guangzhou, Guangdong, China; Key Laboratory of environmental exposure and health in Guangzhou, Jinan University, Guangzhou, Guangdong, China Department of Hand Surgery, China-Japan Union Hospital of Jilin University, Changchun, Jilin, China Key Laboratory of Soft Matter Chemistry; Chinese Academy of Science; Department of Polymer Science and Engineering; iChEM; University of Science and Technology of China Skirball Institute, Department of Neuroscience and Physiology, New York University School of Medicine, New York, NY 10016, USA.; Department of Anesthesiology, New York University School of Medicine, New York, NY 10016, USA. Tissue Engineering and Biomaterials Laboratory, Fischell Department of Bioengineering, A. James Clark School of Engineering, University of Maryland, College Park, Maryland, USA.; NIBIB/NIH Center for Engineering Complex Tissues, University of Maryland, College Park, Maryland, USA. Laboratory of Cerebrovascular Biology and Stroke, Department of Neurology and From the Shanghai Institute of Hematology, State Key Laboratory of Medical Genomics, National Research Center for Translational Medicine at Shanghai, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (Wang, Fan, Jiang, G. Yang, Z. Chen, B. Chen) Dupont Agricultural Products, Stine-Haskell Research Center, P.O. Box 30, Newark, Delaware 19714-0030, Institute of Biophysics, SB RAS, 660036, Krasnoyarsk, Russian Federation, and Department of Medicinal Biochemistry and Biophysics, Karolinska Institute, S-171 77, Stockholm, Sweden Key Lab of Artificial Micro‐ and Nano‐Structures of Ministry of Education of China School of Physics and Technology Wuhan University Wuhan 430072 P. R. China Fudan University State Key Lab Mol Engn Polymers Shanghai 200433 P. R. China for the TESTING Study Group Department of Surgery, West China Hospital Group of Peptides and Natural Products Research School of Pharmaceutical Sciences Southern Medical University Guangzhou China Department of Cardiology, The Second Affiliated Hospital of Harbin Medical University, Harbin 150086, China Breast Cancer Center, Shanghai East Hospital, Tongji University, Shanghai, China (mainland) Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, P.R. China Bing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA; From the Department of Pathophysiology, Key Laboratory of Cardiovascular Disease and Molecular Intervention, Nanjing Medical University, China (B.Z., S.Z., N.L., L.Y., G.Y., X.Z., Y.X.); State Key Laboratory of Natural Medicines, China Pharmaceutical University, Nanjing (Y.Y.); Department of Nursing, Jiangsu Jiankang Vocational University, Nanjing, China (M.F.); and Department of Respiratory Medicine, The Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of... Department of Orthopedic Surgery, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University Department of Industrial and Manufacturing Systems Engineering, Kansas State University, 2080 Rathbone Hall, 1701 D Platt Street, Manhattan, Kansas 66506, United States Bing Center for Waldenstrom’s Macroglobulinemia, Dana Farber Cancer Institute, Boston, Massachusetts 02115, United States; Department of Medical Oncology, Dana Farber Cancer Institute and Harvard Medical School, Boston, Massachusetts 02115, United States National Engineering Research Center of Electromagnetic Radiation Control Materials School of Electronic Science and Engineering University of Electronic Science and Technology of China Chengdu 611731 P. R. China; Key Laboratory of Multi-spectral Absorbing Materials and Structures of Ministry of Education University of Electronic Science and Technology of China Chengdu 611731 P. R. China Department of Urology University of Wisconsin—Madison School of Medicine and Public Health Madison Wisconsin State Key Laboratory of Medicinal Chemical Biology, Department of Cancer Research, College of Life Sciences,Nankai University,Tianjin,China China Innovation Center of Roche, Discovery Virology, Building 5, 371 Lishizhen Road, Shanghai 201203, China Jiangsu Key Laboratory of Marine Bioresources and Environment, Jiangsu Key Laboratory of Marine Biotechnology Jiangsu Ocean University Lianyungang China; China Co‐Innovation Center of Jiangsu Marine Bio‐industry Technology Jiangsu Ocean University Lianyungang China Sports Medicine Department Beijing Jishuitan Hospital No.31, Xin Jie Kou Dong Street, Xi Cheng District 100035 Beijing P. R. China *Department of Immunology, Duke University, Durham, NC 27710; College of Tillage and Cultivation of Heilongjiang Province, Heilongjiang Academy of Agricultural Sciences , Harbin 150000 , China Department of Biomedical Engineering College of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 P. R. China SCNU Environmental Research Institute, Guangdong Provincial Key Laboratory of Chemical Pollution and Environmental Safety & MOE Key Laboratory of Theoretical Chemistry of Environment, South China Normal University, Guangzhou 510006, China; School of Environment, South China Normal University, Guangzhou 510006, China Cardiovascular Research Centre Royal Brompton Hospital London SW3 6NP UK; National Heart and Lung Institute Imperial College London London SW7 2AZ UK Department of Neurology, Beijing Tiantan Hospital, Capital Medical University Department of Chemistry, Bucknell University, Lewisburg, Pennsylvania 17837 Department of Neurology, the Second People's Hospital of Huaian City, Jiangsu, China. Department of Joint Surgery, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong Province 250021, China Institute of Applied Ecology Fujian Agriculture and Forestry University Fuzhou China; Fujian‐Taiwan Joint Centre for Ecological Control of Crop Pests Fujian Agriculture and Forestry University Fuzhou China; Key Laboratory of Integrated Pest Management of Fujian and Taiwan China Ministry Agriculture Fuzhou China; Provincial Key Laboratory of Insect Ecology Fuzhou China Department of Gastroenterology, South China Hospital, Medical School, Shenzhen University, GuangDong, China State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China Department of Biotechnology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China; Department of Parasitology, Medical School, Jinan University, Guangzhou 510632, China Department of Food Nutrition and Safety, Dalian Medical University, Dalian 116044, China Department of Nutrition and Food Safety, College of Public Health, Dalian Medical University, Dalian, Liaoning, PR China; Research Institute of Chemical Defense; Beijing 102205; PR China School of Electronic and Computer Engineering; Peking University Shenzhen Graduate School; Shenzhen 518055; PR China Department of Neurosurgery First Affiliated Hospital of Harbin Medical University Harbin China; Institute of Brain Science Harbin Medical University Harbin China Center for Nanoanalysis and Electron Microscopy (CENEM), Department of Materials Science, University Erlangen-Nürnberg, Cauerstrasse 6, 91058 Erlangen, Germany Department of Neurosurgery The First Affiliated Hospital of Harbin Medical University Harbin Heilongjiang China; The Laboratory of Neurosurgery, Institute of Brain Science Harbin Medical University Harbin Heilongjiang China Animal Husbandry and Veterinary Bureau Binzhou P.R. China Jilin University, Changchun, Jilin Province, China Department of Forensic Science, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China. National Engineering Research Center for Nano-Medicine, Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China Department of Anesthesiology New York University School of Medicine New York NY 10016 Department of Oncology, Shanghai Eastern Hepatobiliary Surgery Hospital, Anting Town, Jiading District, Shanghai, China Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China Department of Chemistry, University of California, Irvine, California 92697-2025 School of Mechanical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, China; Department of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510080, P.R. China The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden; Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University, Baoding, China School of Chemical Engineering and Technology; Tianjin University; Tianjin 300072; China School of Information and Physical Sciences, The University of Newcastle, Newcastle, NSW 2308, Australia Vascular Biology Center Georgia Health Sciences University Augusta GA USA School of Mechanical Engineering, Hebei University of Science and Technology, Shijiazhuang, China. From the Laboratory of Cerebrovascular Biology and Stroke, Department of Neurology, University of Minnesota Medical School, Minneapolis, Minn. State Key Laboratory of NBC Protection for Civilian, Beijing 100191, China Institute of Chinese Materia Medica, Academy of Traditional Chinese Medicine, Beijing 100700, China. Bioengineering Department and Imperial-X, Imperial College London, London, W12 7SL, UK. [email protected]. National Heart and Lung Institute, Imperial College London, London, SW7 2AZ, UK. [email protected]. School of Biomedical Engineering & Imaging Sciences, King's College London, London, WC2R 2LS, UK. [email protected]. Department of Anesthesiology, Perioperative Care, and Pain Medicine, New York University School of Medicine, New York, NY 10016, USA. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA;; Department of Medicine, Brigham and Women's Hospital, Boston, MA; Department of Urology Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China Department of Cancer Genetics and Epigenetics, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA College of Animal Science and Technology, Southwest University, Chongqing 400715, China Department of Biomedical Engineering SUSTech Academy for Advanced Interdisciplinary Studies Southern University of Science and Technology (SUSTech) Shenzhen 518055 China Department of Thoracic Surgery, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Joint Surgery Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan China Electronic Materials Research Laboratory, Key Laboratory of the Ministry of Education and International Center for Dielectric Research, Xi’an Jiaotong University, Xi’an, Shaanxi 710049, China Shanghai Key Laboratory for Pharmaceutical Metabolite Research, School of Pharmacy Second Military Medical University Shanghai P. R. China; Department of Pharmaceutical Analysis, School of Pharmacy Second Military Medical University Shanghai P. R. China Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030-4009, USA State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science; Fudan University; Shanghai 200433; China Dr. Li Dak Sum & Yip Yio Chin Center for Stem Cells and Regenerative Medicine, and Department of Orthopedic Surgery of the Second Affiliated Hospital Zhejiang University Zhejiang China Department of Geriatric Cardiology, The First Affiliated Hospital of Shandong First Medical University, Jinan, China. SINOPEC Shanghai Research Institute of Petrochemical Technology, Shanghai 201208, China Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics and Precision Medicine College of Pharmacy University of Florida Gainesville Florida USA College of Chemistry, Chemical Engineering and Materials Science, Shandong Normal University, Jinan, 250014, P. R. China Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, China; Department of Computer Science and Technology, Wuhan University of Technology, Wuhan 4300702, China Bing Center for Waldenström Macroglobulinemia Dana‐Farber Cancer Institute Harvard Medical School Boston MA USA Department of Industrial and Manufacturing Systems Engineering, Kansas State University, Manhattan, Kansas 66506, United States SIGA Technologies, Inc., Corvallis, Oregon, USA College of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 China National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, People's Republic of China; State Key Laboratory of Earth Surface Processes and Resource Ecology, Beijing Normal University, Beijing 100875, People's Republic of China Bing Center for Waldenström's Macroglobulinemia; Dana Farber Cancer Institute; Brigham and Women's Hospital; Boston MA USA; Departments of Medicine and Pathology; Harvard Medical School; Boston MA USA CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, Key Laboratory of Optoelectronic Science and Technology in Anhui Province, and §Department of Optics and Optical Engineering, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China State Key Laboratory of Crop Stress Biology in Arid Areas College of Agronomy and Yangling Branch of China Wheat Improvement Center Northwest A&F University Yangling Shaanxi 712100 China 1Genitourinary Medical Oncology Department, The University of Texas MD Anderson Cancer Center, Houston, Texas. Department of Immunology, Duke University, Durham, North Carolina, USA The State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai, 200433, China Graduate Department, China Peopleʼs Police University, Langfang 065000, China CSIRO Manufacturing Private Bag 10 Clayton South Victoria 3169 Australia Jiangsu Key Laboratory of Marine Biological Resources and Environment, Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Key Laboratory of Marine Pharmaceutical Compound Screening, Jiangsu Ocean University, Lianyungang, China. Shanghai Institute for Advanced Immunochemical Studies & School of Life Science and Technology ShanghaiTech University Shanghai 201210 P. R. China Department of Gastroenterology, the First Hospital of Harbin, Harbin, Heilongjiang 150010, China Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, People’s Republic of China School of Life Sciences, Northwestern Polytechnical University , Xi’an 710072, China Nanjing Children’s Hospital Nanjing Medical University Nanjing China University of Science and Technology of China The Conversationalist Club, School of Stomatology, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, Shandong 250117, China Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA. Departments of Chemistry and Discovery Biology, Chugai Pharma USA, LLC., 6275 Nancy Ridge Drive, San Diego, California 92121, and Metabolic Modulator Research Ltd. (MMRL), 2020 Research Transition Facility, University of Alberta, Edmonton, Alberta, Canada Department of Otolaryngology Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China School of Environment Northeast Normal University 2555 Jingyue Street Changchun 130117 P. R. China 1State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences;; 5Graduate School of Chinese Academy of Sciences, Beijing, China Department of Ophthalmology Beijing Jishuitan Hospital Beijing China 1Scott Department of Urology and 2Department of Molecular and Cellular Biology, Baylor College of Medicine, and 3Department of Genitourinary Medical Oncology-Research, The University of Texas M.D. Anderson Cancer Center, Houston, Texas Department of Cardiology, Shaanxi Provincial People’s Hospital, Xi’an 710068, Shaanxi, China Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital , Nanjing 210029, China Jiangsu Key Laboratory for Biodiversity and Biotechnology College of Life Sciences Nanjing Normal University Nanjing China Department of Cardiology, Yanbian University Hospital, Yanji, Jilin P.R., China. Orlucent Inc Los Gatos California USA School of Petrochemical Engineering, Changzhou University, Changzhou 213164, China School of Mechanical Engineering, Tongji University, No. 1239, Siping Road, Shanghai 200092, China China Innovation Center of Roche, Building 5, 371 Lishizhen Road, Shanghai 201203, China; Discovery Virology, Building 5, 371 Lishizhen Road, Shanghai 201203, China Department of Hematology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, China 1Department of General Surgery (Department of Pancreatic-Biliary Surgery), Shanghai Changzheng Hospital, The Second Military Medical University, Shanghai, China Scott Department of Urology, Baylor College of Medicine, Houston, TX 77030 Department of Medical Biochemistry and Biophysics, The Rolf Luft Center for Diabetes Research, Department of Molecular Medicine, and Microbiology and Tumor Biology Center, Karolinska Institutet, SE-171 77 Stockholm, Sweden; Diabetes Research Institute, University of Miami, School of Medicine, Miami, FL 33101; Department of Clinical Sciences, Division of Pediatrics, Karolinska University Hospital, Huddinge, SE-141 86 Stockholm, Sweden; and Department of Medical Biosciences and Physiological Chemistry... Department of Pharmacotherapy and Translational Research and Center for PharmacogenomicsCollege of PharmacyUniversity of FloridaGainesvilleFLUSA Department of Anesthesiology, Perioperative Care and Pain Medicine, New York University School of Medicine, New York, United States Key Laboratory of MOE for Plant Developmental Biology, College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, China (Z.-B.Z., G.Y., Z.C., Y.L., H.-J.X.); and Institute of Biochemistry and Biology, University of Potsdam, Potsdam 14469, Germany (F.A.) Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, China Department of Pharmacology, Center for Pharmacogenomics, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA. Shenzhen Key Laboratory of Smart Healthcare Engineering Department of Biomedical Engineering Southern University of Science and Technology (SUSTech) Shenzhen 518055 P. R. China Department of Neurology, Huai’an Second People’s Hospital, The Affiliated Huai’an Hospital of Xuzhou Medical University, Huai’an, China Department of Medical Oncology, Dana−Farber Cancer Institute, Harvard Medical School, 450 Brookline Avenue, Boston, Massachusetts 02115, United States; Bing Center for Waldenström’s Macroglobulinemia, Dana−Farber Cancer Institute, M547, 450 Brookline Avenue, Boston, Massachusetts 02115, United States Jilin Academy of Traditional Chinese Medicine, Changchun 130012, China Electronic Materials Research Laboratory Key Laboratory of the Ministry of Education and International Center for Dielectric Research Xi'an Jiaotong University Xi'an 710049 P.R. China School of Science, Hebei University of Science and Technology, Shijiazhuang, Hebei 050018, China Key Laboratory of Acupuncture-Moxibustion and Immunology, Shanghai Research Institute of Acupuncture and Meridian, Xuhui District, Shanghai 200030, China Department of Pain, Funing County People’s Hospital , Funing County , Yancheng City , Jiangsu Province, 224400 , China Bing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA;; Department of Medicine, Harvard Medical School, Boston, MA; and Key Laboratory of Biomedical Information Engineering of Ministry of Education, Department of Biomedical Engineering, School of Life Science and Technology, Xi'an Jiaotong University, Xi'an, China a Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, People's Republic of China Materials Science and Technology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States Neurosciences Research Centre, Cardiovascular and Cell Sciences Institute, St. George's University of London London UK Bing Center for Waldenström Macroglobulinemia Dana‐Farber Cancer Institute Boston MA USA Zhuhai People's Hospital (Zhuhai Hospital Affiliated with Jinan University) Zhuhai 519000, People's Republic of China. Basic Teaching Department, Jiaozuo University, 3066 Renmin Road, Jiaozuo 454000, China Department of Public Health And Preventive Medicine, School of Medicine, Jinan University, Guangzhou, China; Research Institute of Tropical Forestry, Chinese Academy of Forestry, Guangzhou 510520, China Department of Aging and Geriatric Research, Institute on Aging, University of Florida, Gainesville, FL, USA Department of Orthopaedic Surgery, Center for Cellular and Molecular Engineering, Pittsburgh, Pennsylvania.; Department of Bioengineering, Swanson School of Engineering, Pittsburgh, Pennsylvania. 1Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Tanabe Research Laboratories USA, Inc., 4540 Towne Centre Court, San Diego, California 92121, and Medicinal Chemistry Research Laboratories, Tanabe Seiyaku Co., Ltd, 2-2-50 Kawagishi, Toda-shi, Saitama 335-8505, Japan Department of Anesthesiology Columbia University Medical Center New York NY USA School of Artificial and Intelligence, Beijing University of Posts and Telecommunications, Beijing 100876, China School of Biosciences and Veterinary Medicine, University of Camerino, Camerino, Macerata, Italy; Department of Medicinal Chemistry, University of Florida, Gainesville, Florida, USA Data Recovery Key Laboratory of Sichuan Province, College of Mathematics and Information Science, Neijiang Normal University 1 , Neijiang 641100, People’s Republic of China Shanghai Institute for Advanced Immunochemical Studies (SIAIS), ShanghaiTech University, Shanghai 201210, China The State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai 200433, PR China; Biomass Molecular Engineering Center, Anhui Agricultural University, Hefei, Anhui 230036, PR China Department of Gastrointestinal Cancer Biology, National Key Laboratory of Druggability Evaluation and Systematic Translational Medicine, Tianjin Cancer Institute, Liver Cancer Center, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin's Clinical Research Center for Cancer Tianjin Key Laboratory of Digestive Cancer Tianjin China Department of Respiratory and Critical Care Medicine, the Second Hospital of Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China Department of Pediatrics, PLA General Hospital, Beijing, China; Division of Pediatrics, The First Medical Center of PLA General Hospital, Beijing, China; Medical School of Chinese People’s Liberation Army, Beijing, China; The Second School of Clinical Medicine, Southern Medical University, Guangzhou, China College of Life Science and Technology, Huazhong University of Science &Technology, Wuhan 430074, People’s Republic of China Tobacco College of Henan Agricultural University, Zhengzhou 450002, China Department of Hematology, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, China Duke Human Vaccine Institute, Duke University School of Medicine, Durham, NC 27710, USA. Department of Thoracic Surgery, The First Hospital of Hebei Medical University, Shijiazhuang, Hebei Province, 050000, China Department of Medical Oncology, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA; Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA Institute of Sustainable Industries and Liveable Cities; Victoria University; Melbourne; Australia National Heart and Lung Institute, Imperial College London,London,United Kingdom,SW7 2AZ Department of Cancer Genetics & Epigenetics, Beckman Research Institute, City of Hope, Duarte, CA 91010, USA Department of Gastroenterology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P.R. China Program in Neuroscience and the Department of Neurosurgery, Harvard Medical School, Massachusetts General Hospital, Boston, MA 02114. The State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science Fudan University Shanghai 200433 China Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Jiangsu, China School of Materials Science and Engineering, Shanghai University, Shanghai 200444, China Neuroscience Research Centre, Cardiovascular and Cell Sciences Institute; St. George's, University of London; London UK Bing Center for Waldenström Macroglobulinemia Dana‐Farber Cancer Institute Boston MA USA; Harvard Medical School Boston MA USA From the Cardiovascular Research Group (J.R.B.D., G.D.L.), Departments of Pediatrics and Pharmacology, Faculty of Medicine, University of Alberta, Edmonton, Alberta, Canada; Chugai Pharma USA LLC (J.-F.C., S.B., D.W., T.A., C.H., G.Y., A.M.N.), San Diego, Calif; Department of Physiology and Biophysics (W.C.S., M.P.C.), Case Western Reserve University, Cleveland, Ohio; Metabolic Modulators Research Ltd. (J.R.B.D., R.B., G.D.L.) 2020 Research Transition Facility, University of Alberta, Edmonton,... School of Materials Science and Engineering, Key Laboratory of Advanced Technologies of Material, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, Sichuan, P. R. China; College of Medicine, Southwest Jiaotong University, Chengdu 610031, Sichuan, P. R. China Shukun (Beijing) Technology Company Ltd., Beijing 100102, China Bing Center for Waldenstrom’s Macroglobulinemia,; Department of Medical Oncology, Dana Farber Cancer Institute, and Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin;; Institute of Brain Science, Harbin Medical University, Harbin; Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, 1 Wenyuan Road, Nanjing 210046, People's Republic of China Institute of Resource Biology and Biotechnology, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China School of Science; Hebei University of Technology; Tianjin 300401; People's Republic of China Infectious Disease Discovery, Roche Pharmaceutical Research and Early Development, Roche Innovation Center Shanghai, Shanghai, China Department of Orthopedic Surgery, the Third Hospital of Hebei Medical University; Key Laboratory of Biomechanics of Hebei Province, Shijiazhuang, Hebei, PR China. Experimental Animal Center, West China Hospital, Sichuan University , Chengdu 610041 , China Department of Anesthesiology Sichuan Orthopedics Hospital Chengdu Sichuan China State Key Laboratory of Transducer Technology, Aerospace Information Research Institute of Chinese Academy of Sciences 1 , Beijing, China; School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences 2 , Beijing, China Department of Immunology 1 , 2 , 3 , and 4; Human Vaccine Institute 1 , 2 , 3 , and 4; Department of Biostatistics and Bioinformatics 1 , 2 , 3 , and 4; Department of Biochemistry, Duke University, Durham, NC 27705 1 , 2 , 3 , and 4 Department of Biomedical Engineering College of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 China Key Laboratory of Targeted Intervention of Cardiovascular Disease and Collaborative Innovation Center for Cardiovascular Translational Medicine, Department of Pathophysiology, Nanjing Medical University, China (L.Y., G.Y., X.Z., Z.L., M.F., Y.X.). Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering Southern University of Science and Technology (SUSTech) No. 1088 Xueyuan Rd. Shenzhen Guangdong 518055 P. R. China State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China. College of Resources and Environment, University of Chinese Academy of Sciences, Beijing 101408, China. School of Chemistry and Chemical Engineering, Shandong University of Technology, Zibo 255049, P. R. China Hebei University of Chinese Medicine, Shijiazhuang, Hebei 050200, China Animal Experimental Center West China Hospital Sichuan University Chengdu China School of Sciences, China Pharmaceutical University, Nanjing 211121, China; China Grand Enterprises, Beijing 100101, China School of Integrated Circuit Science and Engineering, Beihang University, Beijing100191, China Laboratory of Neuropharmacology School of Pharmacy, Fudan University Shanghai China; Laboratory of Neuropharmacology Institute of Translational & Precision Medicine, Nantong University Nantong China State Key Laboratory of Medicinal Chemical Biology; Key Laboratory of Functional Polymer Materials, Ministry of Education; and Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300071, P.R. China.; University of Groningen and University Medical Center Groningen, Department of Biomedical Engineering, Antonius Deusinglaan 1, 9713 AV Groningen, Netherlands. Department of Ophthalmology, Beijing Jishuitan Hospital, Peking University 4th Hospital, Beijing 100035, China. Institute of Disease Control and Prevention; Academy of Military Medical Sciences; Beijing, China School of Basic Medical Sciences, Ningxia Medical University, Ningxia Engineering & Technology Research Center for Modernization of Hui Medicine, Yinchuan 750004, China. Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania. Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University Chengdu Sichuan 610031 P. R. China Shanghai Institute for Advanced Immunochemical Studies; ShanghaiTech University; Shanghai; China Department of Orthopedics, and Key Laboratory of Orthopedic Biomechanics of Hebei Province, Orthopedic Research Institution of Hebei Province, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China Department of Neurology The Second People's Hospital of Huai'an The Affiliated Huai'an Hospital of Xuzhou Medical University Huai'an China Department of Geriatrics, Hubei Provincial Hospital of Traditional Chinese Medicine, Wuhan, Hubei 430070, P.R. China Department of Applied Physical Sciences University of North Carolina Chapel Hill NC 27599 USA Beijing Institute of Basic Medical Sciences, Beijing, China; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing, China Institute of Clinical/Medical Research, the First People's Hospital of Foshan, Foshan, Guangdong 528000, China. Biomedical Engineering Department Pennsylvania State University University Park PA 16802 USA Cardiovascular Research Centre, Royal Brompton Hospital, London, SW3 6NP, UK; National Heart and Lung Institute, Imperial College London, London, SW7 2AZ, UK Department of Neurology, Kunshan Hospital of Traditional Chinese Medicine, Kunshan, Jiangsu 215399, China Shanghai Sixth People’s Hospital, Institute of Otolaryngology, Shanghai Jiao Tong University Department of Otolaryngology, , Shanghai 200233, People’s Republic of China [email protected] , [email protected] GlaxoSmithKline Pharmaceuticals, King of Prussia, Pennsylvania 19406 From the Department of Anesthesiology, New York University Medical Center, New York, New York. Shunde Wu Zhong Pei Memory Hospital Foshan Guangdong China Physics Department & Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Materials Science, East China Normal University, North Zhongshan Road 3663, Shanghai 200062, P. R. China College of Mechanical Engineering, Hebei University of Science and Technology, Shijiazhuang 050000, China Vascular Biology Center Shanghai Key Laboratory of Magnetic Resonance East China Normal University Shanghai China Beijing Institute of Basic Medical Sciences, P.O. Box 130 (3), Beijing 100850, China. School of Chemistry and Chemical Engineering Yangzhou University Yangzhou 225002 Jiangsu People's Republic of China The Laboratory of National Key Subject of Forensic Science, Xi'an Jiaotong University, Shaanxi 710061, China. [email protected] Molecular Neurobiology Program, Skirball Institute, Department of Physiology and Neuroscience, New York University School of Medicine, New York, NY 10016; and; Department of Anesthesiology, New York University School of Medicine, New York, NY 10016 Department of Orthopaedic Trauma, The First Hospital of Jilin University, Changchun, China Department of Neonatology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania; Key Laboratory of Advanced Technologies of Material, Minister of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, Sichuan, PR China Department of Pathogen Biology, School of Medicine, Jinan University, Guangzhou, Guangdong, China.; Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou, Guangdong, China. Department of Nephrology, Medical Faculty, Heinrich-Heine University Düsseldorf, 40225 Düsseldorf, Germany; Department of Orthopedics, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin, China; National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, Tianjin, China Department of Electrical and Computer Engineering University of Houston Houston TX 77204 USA Department of Thoracic Surgery, Tangdu Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China Key Laboratory of Molecular Engineering of Polymers of Ministry of Education and Department of Macromolecular Science, Fudan University, Shanghai 200433, China, and Department of Chemical Engineering, Imperial College, London SW7 2BY, U.K. Charles Perkins Centre, School of Molecular Bioscience, University of Sydney, Sydney, New South Wales 2006, Australia.; Garvan Institute of Medical Research, Darlinghurst, New South Wales 2010, Australia. Department of Industrial and Manufacturing Systems Engineering Kansas State University Manhattan KS 66506 USA Department of Surgery of Spine and Spinal Cord, Henan Provincial People's Hospital, Henan Province Intelligent Orthopedic Technology Innovation and Transformation International Joint Laboratory, Henan Key Laboratory for Intelligent Precision Orthopedics, People's Hospital of Zhengzhou University, People's Hospital of Henan University, Henan Zhengzhou Department of Pharmacology, Ningxia Medical University, Yinchuan, China Department of Cardiology, Shaanxi Provincial People’s Hospital, Xi’an, China Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Wuhan, Hubei 430074, China; MoE Key Laboratory for Biomedical Photonics, Collaborative Innovation Center for Biomedical Engineering, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China Britton Chance Center for Biomedical Photonics Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan Hubei 430074 China; MoE Key Laboratory for Biomedical Photonics Collaborative Innovation Center for Biomedical Engineering School of Engineering Sciences Huazhong University of Science and Technology Wuhan Hubei 430074 China Key Laboratory of Physical Oceanography, Ministry of Education/Institute for Advanced Ocean Study/Frontiers Science Center for Deep Ocean Multispheres and Earth System (DOMES), College of Oceanic and Atmospheric Sciences, Ocean University of China , Qingdao 260003 , China State Key Laboratory Breeding Base of Dao-di Herbs, National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. Key Lab of Artificial Micro- and Nano-Structures of Ministry of Education of China, School of Physics and Technology, Wuhan University, Wuhan 430072, People’s Republic of China 4Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts. Department of pharmacology Peking University School of Basic Medical Science Beijing China Operating Room of Anesthesia Surgery Center, West China Hospital/West China School of Nursing, Sichuan University, Chengdu, China. Peking-Tsinghua Center for Life Sciences, State Key Laboratory of Biomembrane and Membrane Biology, PKU-IDG/McGovern Institute For Brain Research, Beijing Advanced Innovation Center for Genomics, School of Life Sciences, Peking University, Beijing, China Department of Cardiology, Yanbian University Hospital Department of Pathology Jinan University School of Medicine Guangzhou China ‡Department of Immunology, Duke University Medical Center, Durham, NC 27710; College of Water Conservancy & Architectural Engineering, Shihezi University, Shihezi Xinjiang 832003 PR China Northwest Institute of Nuclear Technology , Xi’an 710024, China Endocrinology and Metabolic Diseases Laboratory, Tianjin Research Center of Basic Medical Sciences and Metabolic Diseases Hospital, Tianjin Medical University, Tianjin 300070, China Department of Pathogen Biology, School of Medicine, Jinan University, Guangzhou, China Department of Orthopedic Surgery, The Third Hospital of Hebei Medical University, No. 139 Ziqiang Road, Shijiazhuang, Hebei 050051, China are from the Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery University of Pittsburgh School of Medicine Pittsburgh Pennsylvania Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China Department of Geriatric Nephrology, The Second Medical Center & National Clinical Research Center for Geriatric Diseases, The General Hospital of People's Liberation Army, Beijing 100853, China Bing Center for Waldenström Macroglobulinemia Dana‐Farber Cancer Institute Boston MA USA; Department of Medicine Harvard Medical School Boston MA USA Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, 201210 Shanghai, China; CAS Key Laboratory of Soft Matter Chemistry, Department of Polymer Science and Engineering, Key Laboratory of Optoelectronic Science and Technology in Anhui Province University of Science and Technology of China Hefei Anhui 230026 P. R. China School of Physical Education and Chinese Center of Exercise Epidemiology, Northeast Normal University, Changchun, PR China Key Laboratory of Science & Technology of Eco-Textile, Donghua University, Ministry of Education, Shanghai 201620, China Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200001, P.R. China Jiangsu Key Laboratory for Biodiversity and Biotechnology, Nanjing Normal University, Nanjing, China. Electronic address: [email protected]. Charles Perkins Centre, School of Life and Environmental Sciences, The University of Sydney, Sydney, New South Wales 2006, Australia State Key Laboratory of Transducer Technology Aerospace Information Research Institute of Chinese Academy of Sciences Beijing China; School of Electronic, Electrical and Communication Engineering University of Chinese Academy of Sciences Beijing China Department of Geriatric Cardiology, Shandong Provincial Qianfoshan Hospital, Jinan, Shandong 250014, P.R. China Shanghai Institute for Advanced Immunochemical Studies ShanghaiTech University 201210 Shanghai P. R. China Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, People’s Republic of China The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin 300071, People’s Republic of China Materials Science & Engineering, University of Houston, Houston, TX 77204, USA Key Laboratory of Nutrition and Metabolism Institute for Nutritional Sciences Shanghai Institutes for Biological Sciences Chinese Academy of Sciences Graduate School of the Chinese Academy of Sciences Shanghai China Department of Burn and Plastic Surgery Department of Wound Repair Shenzhen Institute of Translational Medicine Shenzhen Second People's Hospital The First Affiliated Hospital of Shenzhen University Health Science Center Shenzhen 518116 China CAS Key Laboratory of Soft Matter Chemistry; Department of Polymer Science and Engineering; Key Laboratory of Optoelectronic Science and Technology in Anhui Province; University of Science and Technology of China; Hefei, P. R. China Department of Orthopedic Surgery; Chinese-Japan Union Hospital of Jilin University; Changchun China 1Scott Department of Urology, Departments of Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China; School of Physical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China Bing Center for Waldenström's Macroglobulinemia Dana Farber Cancer Institute Boston MA USA; Department of Medicine Harvard Medical School Boston MA USA School of Physics and Technology, Wuhan University, Wuhan 430072, People’s Republic of China Institute of Rural Revitalization Science and Technology, Heilongjiang Academy of Agricultural Sciences, Harbin 150028, China Matsunaga-Conte Prostate Cancer Research Center, Scott Department of Urology, Baylor College of Medicine, Houston, TX 77030 Department of ICU and Cardiology, Yanbian University Hospital, Yanji 133000, Jilin, PR China; Department of Community Health & Geriatrics, Nagoya University Graduate School of Medicine, Nagoya 466-8550, Japan. Pharmacy School, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China; School of Medicine, Jianghan University, Wuhan, Hubei 430056, China Department of Medicinal Chemistry and Center for Natural Products, Drug Discovery and Development, University of Florida, Gainesville, Florida 32610, United States Department of Medicinal Chemistry, Center for Natural Products, Drug Discovery and Development, University of Florida, Gainesville, FL 32610; Department of Ophthalmology, Beijing Jishuitan Hospital, Xicheng District, Beijing, China School of Mechanical Engineering Shanghai Jiao Tong University Dongchuan Road 800 Shanghai 200240 China Department of Neurosurgery, First Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang Province, China Kunming Traditional Chinese Medicine Hospital, Yunnan, China. Department of Pathogen Biology, School of Medicine, Jinan University, Guangzhou, China;; Guangzhou Key Laboratory of Environmental Exposure and Health in Guangzhou, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou, Guangdong, China Department of Anesthesiology, New York University School of Medicine, New York, NY, USA. Department of Aging and Geriatric Research, College of Medicine, Institute on Aging University of Florida Gainesville Florida USA College of Medicine, Southwest Jiaotong University, Chengdu 610031, People’s Republic of China Zhuhai Interventional Medical Center, Zhuhai Precision Medical Center, Zhuhai People's Hospital, Zhuhai Hospital Affiliated with Jinan University Guangdong Provincial Key Laboratory of Tumor Interventional Diagnosis and Treatment Zhuhai 519000 P. R. China Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin 150007, China Authors' Affiliations: Departments of 1Genitourinary Medical Oncology–Research, 2Pathology and 3Molecular Carcinogenesis, The University of Texas MD Anderson Cancer Center; 4Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston; and 5Department of Pharmacology, The University of Texas–Austin, Austin, Texas School of Electrical and Electronic Engineering Nanyang Technological University 50 Nanyang Avenue Singapore 639798 Singapore Department of Cancer Research Institute of Molecular Biology College of Life Sciences Nankai University Tianjin China State Key Laboratory of Urban and Regional Ecology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing 100085, China; University of Chinese Academy of Sciences, Beijing 100049, China Beijing Advanced Innovation Center for Food Nutrition and Human Health Beijing Technology & Business University (BTBU) Beijing P. R. China Department of Polymer Science and Engineering, iChEM University of Science and Technology of China Jinzhai Road 96th, Hefei Anhui 230026 P.R. China School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225002 Jiangsu, P. R. China The Matsunaga‐Conte Prostate Cancer Research Center and the Scott Department of Urology, Baylor College of Medicine, Houston, Texas Key Laboratory of Artificial Micro- and Nano-structures of Ministry of Education of China, School of Physics and Technology, Wuhan University, Wuhan 430072, People’s Republic of China Institute of Biomedical Engineering College of Medicine Southwest Jiaotong University Chengdu 610031 P. R. China; Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University Chengdu 610031 P. R. China General Surgery Department, the First Affiliated Hospital of Dalian Medical University, Dalian, China. School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225002, Jiangsu, People's Republic of China Department of Molecular Biology, College of Basic Medical Science, Jilin University, Changchun 130033, Jilin, P.R. China School of Chemistry and Chemical Engineering Yangzhou University Yangzhou Jiangsu 225002 P. R. China School of Computer and Electronic Information/School of Artificial Intelligence, Nanjing Normal University, China Center for Reproductive Medicine The First Affiliated Hospital of Zhengzhou University Zhengzhou China; Henan Key Laboratory of Reproduction and Genetics The First Affiliated Hospital of Zhengzhou University Zhengzhou China School of Materials Science and Engineering, Shanghai University, 99 Shangda Road, Shanghai 200444, China Luoyang Orthopedic Hospital of Henan Province, Luo-yang 471002, Henan Province, China. Physics Department & Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Electronic Science East China Normal University Shanghai China School of Chemical Engineering and Technology; Tianjin University; Tianjin 300350; P. R. China Bing Center for Waldenstrom's Macroglobulinemia Dana Farber Cancer Institute Boston MA USA; Department of Medicine Harvard Medical School Boston MA USA Department of Ophthalmology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Suzhou, China. Department of Immunology, The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, California 92037 Department of Community Healthcare & Geriatrics, Nagoya University Graduate School of Medicine, Nagoya, Japan; Cardiology and ICU, Yanbian University Hospital, Yanji, Jilin Province, China Department of Respiratory Medicine, The Second Hospital of Shanxi Medical University, Taiyuan, Shanxi Department of Pediatrics, the First Medical Centre Chinese PLA General Hospital Beijing China Bing Center for Waldenström’s Macroglobulinemia Dana‐Farber Cancer Institute Boston MA USA; Department of Medicine Harvard Medical School Boston MA USA Materials Science and Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117576, Singapore Guang'anmen Hospital, China Academy of Chinese Medical Sciences Beijing 100053, China. The Medical School Hospital of Qingdao University, Qingdao 266003, China. Department of Stomatology,Affiliated Hospital of Chengde Medical University, Chengde 067000, China. State Key Laboratory of Crop Stress Biology in Arid Areas, College of Agronomy and Yangling Branch of China Wheat Improvement Center, Northwest A&F University, Yangling 712100, Shaanxi, China Division of Gastroenterology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China Key Laboratory of Bioinorganic and Synthetic Chemistry of Ministry of Education School of Chemistry, IGCME GBRCE for Functional Molecular Engineering Sun Yat-Sen University Guangzhou 510275 P. R. China Department of Oncology, BenQ Medical Center, Nanjing Medical University, Nanjing 210029, China Biomass Molecular Engineering Center and Anhui Provincial Key Laboratory of Microbial Pest Control Anhui Agricultural University Hefei 230036 China Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University , Nanjing , China; Southern Marine Science and Engineering Guangdong Laboratory (Guangzhou) , Guangzhou, Guangdong , China CSIRO Manufacturing, Private Bag 10, Clayton South, Melbourne 3169, Victoria, Australia Nanjing Children’s Hospital Affiliated with Nanjing Medical University; Jiangsu Key Laboratory of Molecular Medicine, Medical School, Nanjing University Department of Biotechnology, College of Life Science and Technology, Jinan University, Guangzhou 510632, China. Jiangsu Key Laboratory of Marine Bioresources and Environment, Jiangsu Ocean University, Lianyungang, 222005, P.R. China; Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Ocean University, Lianyungang 222005, P.R. China Nanjing Children's Hospital, Nanjing Medical University, Nanjing, China Shanghai Key Laboratory of Magnetic Resonance School of Physics and Electronic, East China Normal University Shanghai China From the Key Laboratory of Cardiovascular Disease and Department of Pathophysiology (L.Y., G.Y., X.W., P.L., L.L., J.L., Z.F., W.T., X.W., H.X., M.F., Y.J., Y.L., Q.C., Y.X.) and Laboratory Center for Basic Medical Sciences (X.W.), Nanjing Medical University, Nanjing, China; and Department of Surgery, Jiangsu Jiankang Vocational University, Nanjing, China (M.F.). Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, P. R. China Department of Pathogen Biology, School of Medicine, Jinan University, Guangzhou 510632, Guangdong, China;Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 510632, Guangdong, China;The Key Laboratory for Virology of Guangzhou, College of Life Science and Technology, Jinan University, Guangzhou 510632, Guangdong, China. Department of Otolaryngology Head and Neck Surgery Beijing Tongren Hospital Capital Medical Universit Beijing 100730 China; Department of Otorhinolaryngology Head and Neck Surgery Former 263 ClinicalCenter of People's Liberation ArmyGeneral Hospital Beijing Key Laboratory of Head and Neck Molecular Diagnostic Pathology Beijing 100730 China Key Laboratory of Pollution Process and Environmental Criteria, Ministry of Education, College of Environmental Science and Engineering Nankai University Tianjin China; Department of Chemistry, Biophysical Environmental Chemistry Group University of Montreal Montreal Quebec Canada 1Scott Department of Urology, Baylor College of Medicine, Houston, Texas; Basic Teaching Department; Jiaozuo University; Jiaozuo 454000; China State Key Laboratory of Oncology in South China, Department of Imaging and Interventional Radiology, Cancer Center, Sun Yat‑sen University, Guangzhou, Guangdong 510060, P.R. China The State Key Laboratory of Molecular Engineering of Polymers Department of Macromolecular Science and Collaborative Innovation Center of Genetics and Development Fudan University Shanghai 200433 China Histocompatibility and Immunogenetics Laboratory, Alberta Precision Laboratories Calgary Canada College of Pharmacy, Hebei University of Chinese Medicine Shijiazhuang 050200, China China Academy of Chinese Medical Sciences Beijing 100700, China. Department of Cardiology and Hypertension, Jilin Provincial Key Laboratory of Stress and Cardiovascular Disease Yanbian University Hospital Yanji Jilin China Department of Ophthalmology, Beijing Jishuitan Hospital, Beijing, China The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, SE-171 76 Stockholm, Sweden;; Institute of Pharmacology, Jilin Academy of Traditional Chinese Medicine, Changchun 130021, China; Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, P. R. China Shanghai Key Laboratory of Magnetic Resonance and Department of Physics and Material Science East China Normal University Shanghai China Department of Chemistry and Biochemistry, University of Maryland, College Park, Maryland 20742 Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, People’s Republic of China; Medical Experimental Center, School of Medicine, Jianghan University, Wuhan, Hubei 430056, P.R. China Institute of Neuroscience and MOE Key Laboratory of Molecular Neurobiology Neuroscience Research Center of Changzheng Hospital Second Military Medical University Shanghai 200433 China Bing Center for Waldenström Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA, USA Shanghai Institute for Advanced Immunochemical Studies ShanghaiTech University 201210 Shanghai China Cultivation and Crop Tillage Institute, Heilongjiang Academy of Agricultural Sciences , Harbin, China Histocompatibility and Immunogenetics Laboratory, Alberta Precision Laboratories Calgary Alberta Canada Department of Cardiology, Yanbian University Hospital, Juzijie, Yanji, Jilin Province, China From the Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94305. Department of Urology, The Affiliated Zhuzhou Hospital XiangYa Medical College CSU, Zhuzhou 412007, China Department of Joint Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China Department of Pulmonary & Critical Care Medicine, The Second Hospital of Shanxi Medical University, Taiyuan 030001, PR China The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, People’s Republic of China Department of Anesthesiology New York University School of Medicine New York New York 10016 Department of Chemistry, University of Puerto Rico, Rio Piedras Campus, P.O. Box 23346, San Juan, Puerto Rico 00931 Scott Department of Urology, Baylor College of Medicine, Houston, Texas 77030, USA. Department of Minimally Invasive Intervention State Key Laboratory of Oncology in South China Guangdong Provincial Clinical Research Center for Cancer Sun Yat‐sen University Cancer Center Guangzhou 510060 P. R. China East China Normal University Shanghai Key Laboratory of Magnetic Resonance, , P.R, . China Biosensor National Special Laboratory, College of Biomedical Engineering and Instrument Science, ‡Cyrus Tang Center for Sensor Materials and Applications, and §State Key Laboratory of CAD & CG, Zhejiang University, Hangzhou 310027, P. R. China State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials, Ministry of Education, Institute of Polymer Chemistry, College of Chemistry, Nankai University, Tianjin 300350, P. R. China; University of Groningen and University Medical Center Groningen, Department of Biomedical Engineering, Antonius Deusinglaan 1, Groningen 9713 AV, The Netherlands Department of Orthopaedics, the People's Hospital of Zhuji, Zhuji 311800, Zhejiang, China. [email protected] SIGA Technologies, Inc., Corvallis, OR, USA College of Energy and Environmental Engineering; Hebei University of Engineering; Handan 056038; P. R. China School of Materials Science and Engineering; Nanyang Technological University; Singapore; Interdisciplinary Graduate School; Nanyang Technological University School of Civil and Architecture Engineering, Hunan University of Arts and Science, Changde 415000, China . . State Key Laboratory of Offshore Oil Exploitation, CNOOC, Beijing 100028, PR China Diabetes and Obesity Program, Garvan Institute of Medical Research, Darlinghurst, NSW 2010, Australia Chemical Sciences Division Oak Ridge National Laboratory Oak Ridge TN 37830 USA Business Economics Research Institute, Harbin University of Commerce, Harbin, Heilongjiang, China Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China Life Science Research Center, School of Life Science and Technology, Xidian University , Xi’an , China; Engineering Research Center of Molecular and Neuroimaging, Ministry of Education , Xi’an , China Department of Pathogen Biology, School of Medicine, Jinan University, Guangzhou, China.; Guangzhou Key Laboratory of Environmental Exposure and Health, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou, China. Department of Biochemistry and Molecular Biology Dalian Medical University No. 9 W. Lushun South Road Dalian 116044 China; Department of Toxicology Dalian Medical University Dalian 116044 China 1Bing Center for Waldenstrom's Macroglobulinemia at the Dana-Farber Cancer Institute; and Harvard Medical School, Boston, Massachusetts. Bing Center for Waldenström’s Macroglobulinemia, Dana-Farber Cancer Institute, Boston, Massachusetts, USA; Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA Department of Biomedical Engineering, College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University Chengdu 610031 China Torrey Pines Institute of Molecular Studies, 550 General Atomics Court, 2-129, San Diego, California 92121 State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer Materials Ministry of Education Institute of Polymer Chemistry College of Chemistry Nankai University Tianjin 300350 P. R. China; University of Groningen and University Medical Center Groningen Department of Biomedical Engineering Antonius Deusinglaan 1 9713 AV Groningen The Netherlands School of Acupuncture-moxibustion and Tuina, Beijing University of Chinese Medicine, Beijing 100029, China. Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 200031, China Institute for Sustainable Industries and Liveable Cities, Victoria University, P.O. Box 14428, Melbourne, Victoria 8001, Australia; CSIRO Manufacturing, Private Bag 10, Clayton South, Victoria 3169, Australia Neonatal Center, Beijing Children's Hospital, Capital Medical University, Beijing; Department of Pediatrics, Shanxi Medical University Department of Otolaryngology Shanghai Jiao Tong University Affiliated Sixth People’s Hospital Otolaryngology Institute of Shanghai Jiao Tong University Shanghai China Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai, China. National Engineering Research Center for Nano-Medicine; Department of Biomedical Engineering; College of Life Science and Technology; Huazhong University of Science and Technology; Wuhan 430074 China Department of Nephrology, Medical Faculty, University Hospital Düsseldorf, Heinrich Heine University Düsseldorf, Düsseldorf, Germany;; The Shenzhen Key Laboratory of Health Sciences and Technology, Graduate School at Shenzhen, Tsinghua University, Shenzhen, China; Department of Pain Medicine, Taian City Central Hospital, Taian, Shandong, China Department of Acupuncture-Moxibustion, Beijing Xuanwu Hospital of TCM, Beijing 100050, China. [email protected] 2Urology, and Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University Authors' Affiliations: Departments of 1Genitourinary Medical Oncology, 2Systems Biology, and 3Pathology, The University of Texas MD Anderson Cancer Center; 4Scott Department of Urology, Departments of 5Molecular and Cellular Biology and 6Pathology, Baylor College of Medicine; and 7Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas National Heart and Lung Institute Imperial College London London UK; Cardiovascular Research Centre Royal Brompton Hospital London UK Muscle and Motility Group, Boston Biomedical Research Institute, Watertown, Massachusetts 02472, Neurology Service, Massachusetts General Hospital, Boston, Massachusetts, 02114, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, Massachusetts 02115, Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, and Department of Biochemistry, Tufts University School of Medicine, Boston, Massachusetts 02111 College of Chemistry and Green Catalysis Center Zhengzhou University Zhengzhou 450001 China 1Wellman Center for Photomedicine, Bing Center for Waldenström's Macroglobulinemia Dana‐Farber Cancer Institute Boston MA USA; Department of Medicine Harvard Medical School Boston MA USA Department of Physics and Astronomy and Curriculum in Applied and Materials Sciences, University of North Carolina, Chapel Hill, North Carolina 27599, National Institute for Materials Science, Tsukuba 305-0047, Japan, and Department of Chemistry, Duke University, Durham, North Carolina 27708 Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing 210046, China Key Laboratory of Advanced Technologies of Material, Minister of Education, School of Materials Science and Engineering & School of Mechanical Engineering, Southwest Jiaotong University, Chengdu 610031, China Senior Department of Pediatrics, The Seventh Medical Center of PLA General Hospital , Beijing , China; Department of Pediatrics Medical School of Chinese People's Liberation Army , Beijing , China; Department of Pediatrics, The First Medical Center, Chinese PLA General Hospital , Beijing , China; The Second School of Clinical Medicine, Southern Medical University , Guangzhou , China State Key Laboratory of Medicinal Chemical Biology and College of Pharmacy, Nankai University, Tianjin, China Department of Oncology, BenQ Medical Center, Nanjing Medical University, Nanjing, China Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University, Shanghai 201210, China Department of Polymer Science and Technology; School of Chemical Engineering and Technology; Tianjin University; Tianjin; 300350 Bing Center for Waldenstrom’s Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA;; Department of Medicine, Harvard Medical School, Boston MA; and Department of Geriatric Endocrinology, Chinese PLA General Hospital, No. 28 Fuxing Road, Beijing 100853, China National Key Laboratory of Science and Technology on Micro/Nano Fabrication, Department of Micro/Nano Electronics, Shanghai Jiao Tong University 2 , Shanghai 200240, China Department of Biochemistry and Molecular Biology, Zhongshan Medical College, Sun Yat-sen University, Guangzhou, Guangdong, PR China. ViroPharma Incorporated, Exton, Pennsylvania Bing Center for Waldenström's Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA;; Harvard Medical School, Boston, MA; and College of Medicine Southwest Jiaotong University Chengdu 610031 China Department of Genitourinary Medical Oncology; The University of Texas MD Anderson Cancer Center; Houston TX Department of Physics and State Key Laboratory of Surface Physics, Fudan University, Shanghai 200433, China; East China Normal University 2 Department of Physics, , 3663 North Zhongshan Road, Shanghai 200062, China School of Public Health, University of Saskatchewan, Saskatoon, SK, Canada Institute of Medical Researches, the First People's Hospital of Foshan, Foshan 528000, China. International Center for Dielectric Research, Xi’an Jiaotong University, Xi’an 710049, P. R. China Department of Pharmaceutical Analysis School of Pharmacy Second Military Medical University Shanghai P.R. China; Shanghai Key Laboratory for Pharmaceutical Metabolite Research Shanghai P.R. China; Shanghai Research Centre for Drug (Chinese Materia Medica) Metabolism Shanghai P.R. China Roche Innovation Center Shanghai,Shanghai,China State Key Laboratory of famous-region drug,National Resource Center for Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, Nanjing, China School of Geography, South China Normal University, Guangzhou 510631, China; Guangdong Shida Weizhi Information Technology Co., Ltd., Qingyuan 511500, China; SCNU Qingyuan Institute of Science and Technology Innovation, Qingyuan 511500, China Department of Anesthesiology, The Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China College of Science Hebei University of Science and Technology Shijiazhuang 050018 P. R. China Department of Basic and Clinical Pharmacology, School of Pharmacy, Anhui Medical University, Hefei, China; Anhui Province Key Laboratory of Major Autoimmune Diseases, School of Pharmacy, Anhui Institute of Innovative Drugs, Anhui Medical University, Hefei, China School of Life Science and Technology ShanghaiTech University China College of Medical Laboratory Dalian Medical University Dalian China School of Materials Science and Engineering, Nanyang Technological University, 639798, Singapore Department of Bioengineering, University of California, Los Angeles, California 90095, United States; California NanoSystems Institute, Jonsson Comprehensive Cancer Center and Center for Minimally Invasive Therapeutics, University of California, Los Angeles, California 90095, United States; Joint Department of Biomedical Engineering, University of North Carolina at Chapel Hill and North Carolina State University, Raleigh, North Carolina 27695, United States; College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai, 201620, People’s Republic of China SIGA Technologies, Inc., Corvallis, Oregon 97333 The State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai 200433, People’s Republic of China School of Chemical Engineering and Technology; Tianjin University; Tianjin 300050; China; Collaborative Innovation Center of Chemical Science and Engineering Department of Chemistry, Tufts University, 62 Talbot Avenue, Medford, Massachusetts 02155, United States Department of Medical Oncology and; Bing Center for Waldenström’s Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA; Department of Cardiology and ICU Yanbian University Hospital Yanjin 133000 Jilin PR. China The Second Ward of Oncology and Hematology Department, The People’s Hospital of XiangXiang, Xiangxiang, China Department of Experimental Animal Center, West China Hospital, Sichuan University, Chengdu, China. Shanghai Aerospace Power Technology Co., LTD Shanghai 201112 P.R. China Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, TX 77030–4009, USA. Department of Anesthesiology, Affiliated Hospital of Hebei University, Baoding, Hebei 071000, P.R. China Bing Center for Waldenström’s Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA; Department of Medicine, Harvard Medical School, Boston, MA 1Bing Center for Waldenstrom’s Macroglobulinemia, and; 2Department of Medical Oncology, Dana-Farber Cancer Institute and Harvard Medical School, Boston, MA; Stanford Cardiovascular Institute, Stanford, CA 94305, USA; Veterans Affairs Palo Alto Health Care System, Palo Alto, CA 94304,USA School of Materials Science and Engineering; Nanyang Technological University; Singapore The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, and Tianjin Key Laboratory of Molecular Drug Research, Nankai University, Tianjin 300071, People’s Republic of China Fudan University 1 Key Laboratory of Molecular Engineering of Polymers of Ministry of Education, and Department of Macromolecular Science, , Shanghai 200433, China Department of Pathology Loma Linda University Medical Center Loma Linda California State Key Laboratory of Forest Genetics and Tree Breeding Northeast Forestry University Harbin Heilongjiang 150040 China 3Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China Departments of Medicinal Chemistry, Enzymology, Oncology, and Structural Biology, GlaxoSmithkline, King of Prussia, Pennsylvania 19406 Department of Pathology, Mudanjiang Medical University Mudanjiang, Heilongjiang, China. Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences Okayama, Japan. Division of Gastroenterology, First Affiliated Hospital Sun Yat‐Sen University Guangzhou Guangdong 510080 People's Republic of China From the Department of Medical Oncology, Dana Farber Cancer Institute, Boston, MA; Department of Medicine, Harvard Medical School, Boston, MA; Department of Pediatrics, Vanderbilt University Medical Center, Nashville, TN; and Department of Medicine, Brigham and Women's Hospital, Boston, MA. Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, 150001, China; Institute of Brain Science, Harbin Medical University, Harbin, 150001, China Department of Nutrition and Food Hygiene, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Ministry of Education Key Laboratory of Environment, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China Bing Center for Waldenstrom Macroglobulinemia Dana‐Farber Cancer Institute Harvard Medical School Boston MA USA Experimental Animal Center, West China Hospital, Sichuan University, Chengdu, P.R. China. Department of Biological Sciences Emporia State University Emporia Kansas Department of Spinal Cord Surgery, Henan Provincial People’s Hospital, Zhengzhou, China; People’s Hospital of Zhengzhou University, Zhengzhou, China School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue 639798 Singapore Singapore; Interdisciplinary Graduate School Nanyang Technological University 50 Nanyang Avenue 639798 Singapore Singapore State Key Laboratory of Offshore Oil Exploitation, CNOOC Research Institute, No. 6, Taiyanggong South Street, Chaoyang District, Beijing 100027, P. R. China School of Physical Education, Chinese Center of Exercise Epidemiology, Northeast Normal University, Changchun, China. Department of Oncology, BenQ Medical Center, Nanjing Medical University, Nanjing 210029, Jiangsu Province, P. R. China College of Desert Control Science and Engineering, Inner Mongolia Agricultural University, Hohhot, Inner Mongolia, China Hand Surgery, China-Japan Friendship Hospital Affiliated to Jilin University, Changchun, Jilin 130033, P R China. [email protected] Department of Neurobiology and Anatomy University of Utah Salt Lake City Utah; Neuroscience Graduate Program University of Utah Salt Lake City Utah Department of Pathology and Laboratory Medicine, Loma Linda University Medical Center Loma Linda CA USA Shenzhen Key Laboratory of Smart Healthcare Engineering, Department of Biomedical Engineering, Southern University of Science and Technology (SUSTech), Shenzhen 518055, China Key Laboratory of Jiangxi Province for Persistent Pollutants Control and Resources Recycle, Nanchang Hangkong University, Nanchang 330063, China; Biomass Molecular Engineering Center, Anhui Agricultural University, Hefei 230036, China Department of Pediatrics , Chinese PLA General Hospital , Beijing, 100853 , China College of Life Sciences Northwest Normal University Lanzhou China Department of Nutrition and Food Hygiene Dalian Medical University Dalian China Shanghai Institute for Advanced Immunochemical Studies (SIAIS), ShanghaiTech University, Shanghai 201210, P. R. China Bing Center for Waldenström’s Macroglobulinemia, Dana-Farber Cancer Institute, and; Department of Medicine, Harvard Medical School, Boston, MA; Department of Bioengineering, Imperial College London, London, UK College of Life Science and Technology, Huazhong University of Science and Technology, Wuhan 430074, China Department of Electrical Computer Engineering, University of Houston, Houston, Texas 77204, United States Department of Community Healthcare & Geriatrics Nagoya University Graduate School of Medicine Nagoya 466‐8550 Aichiken Japan; Department of Cardiology and ICU Yanbian University Hospital Yanji 133000 Jilin China Department of Pharmacotherapy and Translational Research and Center for Pharmacogenomics, University of Florida, Gainesville, FL Department of Molecular Biology College of Basic Medical Sciences Jilin University Changchun P.R. China Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China Anhui Laboratory of Molecule-Based Materials College of Chemistry and Materials Science Anhui Normal University Wuhu 241002 China ViroPharma Incorporated, 397 Eagleview Boulevard, Exton, Pennsylvania 19341, United States Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, Maryland 21702, University of Alabama, Birmingham, Alabama 35294, and SIGA Technologies, Inc., 4575 SW Research Way, Corvallis, Oregon 97333 Department of Chemistry Nanchang University 999 Xuefu Avenue Nanchang 330031 China Department of Materials Science, Fudan University, Shanghai 200433, P. R. China Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, Australia Department of Orthopedics, The Second Affiliated Hospital of Soochow University, Suzhou, China Department of Urology, Zhuzhou Central Hospital, Zhuzhou 412007, China State Key Laboratory Breeding Base of Dao-di Herbs, Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China. Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai 200062, P. R. China. Guangzhou University of TCM, Guangzhou 510405. [email protected] College of Plant Protection, Fujian Agricultural and Forestry University, Fuzhou 350002, China. [email protected] College of Polymer Science and Engineering; State Key Laboratory of Polymer Materials Engineering; Sichuan University; Chengdu; P. R. China The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, No. 38 Tongyan Road, Jinnan District, Tianjin 300350, P.R. China College of Medicine, Southwest Jiaotong University, Chengdu 610031, China School of Life and Environmental Sciences, The Charles Perkins Centre, The University of Sydney, Sydney, NSW 2006, Australia Key Laboratory of Systems Biology, Shanghai Institute of Biochemistry and Cell Biology (SIBCB), Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Science (CAS), Shanghai, China College of Chemical Engineering Hebei United University Tangshan Hebei 063009 China Nanjing Children's Hospital, Nanjing Medical University, 72 Guangzhou Road, Nanjing 210008, China Children's Hospital of Nanjing Medical University, Nanjing, China. [email protected]. Aero-propulsion, Mechatronics, and Energy Center, Florida State University, Tallahassee, Florida 32310, United States; The National High Magnetic Field Laboratory, Florida State University, Tallahassee, Florida 32310, United States Shanghai Institute for Advanced Immunochemical Studies, ShanghaiTech University Bing Center for Waldenström’s Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA;; Department of Medicine, Harvard Medical School, Boston, MA; Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong, University of Science and Technology, Wuhan, Hubei 430074, China; MoE Key Laboratory for Biomedical Photonics, Collaborative Innovation Center for Biomedical Engineering, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan, Hubei 430074, China National Engineering Research Center for Nano‐Medicine Department of Biomedical Engineering College of Life Science and Technology Huazhong University of Science and Technology Wuhan 430074 China Department of Pathology and Laboratory Medicine Loma Linda University Medical Center Loma Linda CA USA Business Analytics, Dun & Bradstreet Inc. , Short Hills, New Jersey 07078 , U.S.A. Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio, TX, USA. State Key Laboratory of NBC Protection for Civilian, Beijing 102205, PR China College of Mechanical Engineering, Hebei University of Science and Technology, Shijiazhuang 050018, China Bing Center for Waldenström’s Macroglobulinemia, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA Institute of Ophthalmology, School of Medicine, Jinan University, Guangzhou, China 1 Department of Pathology, 2 Department of Medicine, 3 Division of General Surgery, Loma Linda University Medical Center, Loma Linda, California 92354, USA. Thoracic Surgery Tangdu Hospital Fourth Military Medical University Xi'an China Department of Stomatology, Xi’an Medical University, Xi’an, Shannxi Province, China Department of Medical Oncology, Bing Center for Waldenstrom’s Macroglobulinemia, Dana Farber Cancer Institute and Harvard Medical School, Boston, MA; Electronic Materials Research Laboratory, Key Laboratory of the Ministry of Education & International Center for Dielectric Research, Xi’an Jiaotong University, Xi’an 710049, China Department of Medicinal Chemistry Center for Natural Products, Drug Discovery and Development University of Florida Gainesville FL 32610 USA College of Water Conservancy and Architectural Engineering, Shihezi University, Shihezi, People’s Republic of China; Key Laboratory of Modern Water-Saving Irrigation of the Xinjiang Production and Construction Corps, Shihezi, People’s Republic of China School of Forestry, Northeast Forestry University, Harbin 150040, China. [email protected] Department of Hand Surgery, China-Japan Union Hospital of Jilin University, Changchun, China Institute of Translational Research, Tongji Hospital, the School of Life Sciences and Technology, Shanghai Key Laboratory of Signaling and Disease Research, Tongji University, Shanghai 200092, China State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Institute of Applied Ecology, Fujian Agriculture and Forestry University , Fuzhou , China Laboratory of Cerebrovascular Biology and Stroke, Department of Neurology; Aero-Propulsion, Mechatronics, and Energy Center, Florida State University, 2003 Levy Avenue, Tallahassee, Florida 32310, United States; Department of Chemical & Biomedical Engineering, College of Engineering, Florida A&M University−Florida State University, 2525 Pottsdamer Street, Tallahassee, Florida 32310, United States Key Laboratory of Artificial Micro‐ and Nano‐structures of Ministry of Education of China School of Physics and Technology Wuhan University Wuhan 430072 P. R. China; Department of Electronic and Information Engineering The Hong Kong Polytechnic University Hung Hom Kowloon Hong Kong SAR China Beijing Institute of Basic Medical Sciences Beijing China Department of Hematology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China Department of Pathogen Biology, School of Medicine, Jinan University, Guangzhou 510632, China Division of Nephrology, Heinrich-Heine University of Dusseldorf, Dusseldorf, Germany; Division of Neurobiology, Department of Neurology and Neuroscience, Weill Medical College of Cornell University, New York, New York 10021 Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai, PR China Beijing Institute of Basic Medical Sciences, Beijing, China; State Key Laboratory of Toxicology and Medical Countermeasures, Beijing, China 1Wellman Center for Photomedicine, 2Division of Dermatopathology, and 3Melanoma and Pigmented Lesion Center, Massachusetts General Hospital; 4Harvard/Partners Center for Genetics and Genomics, Brigham and Women's Hospital, Boston, Massachusetts; and 5Department of Dermatology, M.D. Anderson Cancer Center, Houston, Texas Shanghai Key Laboratory of Magnetic Resonance and Department of Physics East China Normal University Shanghai China Division of Cancer Medicine, Department of Genitourinary Medical Oncology The University of Texas MD Anderson Cancer Center, 1515 Holcombe Boulevard Houston TX School of Materials and Metallurgy, Guizhou University, Jiaxiu South Road, Huaxi District, Guiyang550025, P. R. China State Key Laboratory of New Ceramics and Fine Processing, Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, People’s Republic of China Department of Pediatrics, Shanxi Medical University, Taiyuan, Shanxi 030001, P.R. China Jiangsu Key Laboratory for Biodiversity and Biotechnology, College of Life Sciences, Nanjing Normal University, China Brain Research Centre, University of British Columbia, 2211 Wesbrook Mall, Vancouver, British Columbia V6T 2B5, Canada. School of Materials Science and Engineering Key Laboratory of Advanced Technologies of Material Minister of Education Southwest Jiaotong University Chengdu 610031 P. R. China Department of Biomedical Engineering The Pennsylvania State University 205 Hallowell Building University Park PA 16802 USA Department of Pathology Jinan University School of Medicine Guangzhou China; Department of Chemistry, College of Chemistry and Material Science Jinan University Guangzhou China Oncology Disease Area and Developmental and Molecular Pathways, Novartis Institutes for Biomedical Research, Cambridge, Massachusetts Shanghai Institute for Advanced Immunochemical Studies ShanghaiTech University Shanghai 201210 China Department of Nutrition & Food Safety, School of Public Health Dalian Medical University Dalian China The State Key Laboratory of Molecular Engineering of Polymers and Department of Macromolecular Science, Fudan University, Shanghai 200433, China Key Lab of Artificial Micro- and Nano-Structures of Ministry of Education of China; Department of Electronic Science & Technology; School of Physics and Technology; Wuhan University; Wuhan 430072 Fujian-Taiwan Joint Centre for Ecological Control of Crop Pests, Fujian Agriculture and Forestry University, Fuzhou, China Department of Experimental Animal Center West China Hospital Sichuan University Chengdu Sichuan China School of Medical Instrument and Food Engineering University of Shanghai for Science and Technology Shanghai China Department of General Surgery, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Neurosurgery, The First Affiliated Hospital of Harbin Medical University, Harbin, People’s Republic of China; Institute of Brain Science, Harbin Medical University, Harbin, People’s Republic of China Department of Anesthesiology Columbia University Irving Medical Center New York New York USA Experimental Animal Center, West China Hospital, Sichuan University, Chengdu 610041, China School of Water Conservancy and Architectural Engineering; Shihezi University; Shihezi 8320000; PR China Department of Food Nutrition and SafetyDalian Medical UniversityNo. 9, West Segment of South Lvshun RoadDalian116044 Liaoning China Department of Cardiology, Shaanxi Provincial People's Hospital State Key Laboratory of Medical Genomics and Shanghai Institute of Hematology, Department of Medical Laboratory Science, Ruijin Medical College, and Department of Pathology, Rui Jin Hospital Affiliated to Shanghai Second Medical University, 197 Rui Jin Road II, Shanghai 200025, China; Health Science Center, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences and Shanghai Second Medical University, Shanghai 200025, China; and Institute of Biological Science, TsingHua University,... School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, Jiangsu, People’s Republic of China Shandong Provincial Key Laboratory of Plant Stress Research, College of Life Science, Shandong Normal University, Ji’nan, 250014, Shandong, People’s Republic of China Molecular Enzymology Group, University of Groningen, Nijenborgh 4, 9747AG Groningen, The Netherlands Institute of Genetic Resources, Nanjing Normal University, Nanjing 210097, China. [email protected] Department of Industrial and Manufacturing Systems Engineering; Kansas State University; Manhattan; USA Department of Pediatrics, the General Hospital of PLA, Beijing 100853, China. Department of Hepatobiliary Surgery, Songshan General Hospital, Chongqing, China Department of Medical Genetics, Cumming School of Medicine, Calgary, AB, Canada; Alberta Children's Hospital Research Institute, Calgary, AB, Canada; Department of Biochemistry and Molecular Biology, Cumming School of Medicine, Calgary, AB, Canada; Owerko Center, University of Calgary, Calgary, AB, Canada. Electronic address: [email protected]. School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, 225002 Jiangsu, P.R. China Department of Intelligent Mechanical Systems Engineering, Kochi University of Technology, Kami 7828502, Japan State Key Laboratory of Ecological Pest Control for Fujian‐Taiwan Crops Institute of Applied Ecology Fujian Agriculture and Forestry University Fuzhou 350002 China; Joint International Research Laboratory of Ecological Pest Control Ministry of Education Fuzhou 350002 China; Key Laboratory of Integrated Pest Management for Fujian‐Taiwan Crops Ministry of Agriculture Fuzhou 350002 China Animal Center, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P R China Laboratory of Transplant Engineering and ImmunologyRegenerative Medicine Research CenterDepartment of Pancreatic SurgeryWest China HospitalSichuan University Chengdu China Department of Pathogen Biology, School of Medicine, Jinan University, Guangzhou 510632, Guangdong, China; Guangzhou Key Laboratory of Environmental Exposure and Health, Guangdong Key Laboratory of Environmental Pollution and Health, Jinan University, Guangzhou 510632, Guangdong, China 1Scott Department of Urology, and School of Chemical Engineering and Technology; Tianjin University; Tianjin 300350; China SIGA Technologies, Inc., Corvallis, Oregon Department of Electronic and Information Engineering The Hong Kong Polytechnic University Kowloon 999077 Hong Kong From the Scott Department of Urology, Veterans Affairs Medical Center and Departments of Pathology, Cell and Molecular Biology and Radiology, Baylor College of Medicine, Houston, Texas Center for Cellular and Molecular Engineering, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; McGowan Institute for Regenerative Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.; Department of Bioengineering, University of Pittsburgh Swanson School of Engineering, Pittsburgh, Pennsylvania. Bing Center for Waldenström's Macroglobulinemia Dana‐Farber Cancer Institute Boston Massachusetts USA; Department of Medicine Harvard Medical School Boston Massachusetts USA Department of Information Science and Engineering, Chongqing Jiaotong University, Chongqing 400074, China Department of Orthopedics Xiangya Hospital, Central South University Changsha Hunan China; National Clinical Research Center for Geriatric Disorders Xiangya Hospital, Central South University Changsha Hunan China National Engineering Research Center for Nano-Medicine; Department of Biomedical Engineering; College of Life Science and Technology; Huazhong University of Science and Technology; Wuhan Division of Systems Engineering, Boston University, Boston, MA, USA. Jiangsu Key Laboratory of Marine Bioresources and Environment/Jiangsu Key Laboratory of Marine Biotechnology, Jiangsu Ocean University, Lianyungang 222005, China; China Co-Innovation Center of Jiangsu Marine Bio-industry Technology, Jiangsu Ocean University, Lianyungang 222005, China; College of Ocean Food and Biochemical Engineering, Jiangsu Ocean University, Lianyungang 222005, China Department of Biochemistry & Molecular Biology, Alberta Children’s Hospital Research Institute, University of Calgary, Calgary, AB, Canada; Department of Medical Genetics, University of Calgary, Calgary, AB, Canada Department of Laboratory Medicine and Pathology Mayo Clinic Rochester MN USA *Division of Neonatology, Children's Hospital of Philadelphia, Philadelphia, PA 19014; State Key Laboratory of Ultrafast Laser Spectroscopy/Department of Chemistry, Zhongshan University, Guangzhou, 510275, P.R. China Zhuzhou Central Hospital, ZhuZhou, Hunan 412000, China School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China Department of Pathology and Laboratory Medicine Hospital of the University of Pennsylvania Philadelphia Pennsylvania USA Physics Department & Shanghai Key Laboratory of Magnetic Resonance School of Physics and Materials Science East China Normal University North Zhongshan Road 3663 200062 Shanghai P. R. China Experimental Animal Center, West China Hospital, Sichuan University, Chengdu 610041, P.R.China. College of Resource and Environment, Southwest University, Chongqing 400715, China. College of Pharmacy Nankai University Tianjin P. R. China Molecular Enzymology Group University of Groningen The Netherlands Department of Chemical Engineering; Dalian University; Dalian; China Department of Polymer Science and Technology, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China Vascular Biology Center and Department of Nephrology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China The State Key Laboratory of Medicinal Chemical Biology, College of Pharmacy, Nankai University, Tianjin 300071, China The Key Laboratory of Geriatrics, Beijing Institute of Geriatrics, Beijing Hospital, National Center of Gerontology, National Health Commission; Institute of Geriatric Medicine, Chinese Academy of Medical Sciences, Beijing 100730, China Bing Center for Waldenström’s Macroglobulinemia, Dana-Farber Cancer Institute, Boston, MA; Department of Respiratory and Critical Care Medicine, The Second Hospital of Shanxi Medical University Taiyuan 030001, China. Department of General Medicine, Xiangya Hospital, Central South University, Changsha 410008, China. [email protected]. Beijing National Laboratory for Condensed Matter Physics; Institute of Physics; Chinese Academy of Sciences; Beijing 100190; China Department of Clinical Laboratory The Fifth Medical Center of Chinese PLA General Hospital Beijing China Laboratory of Acupuncture-Moxibustion and Immunology, Shanghai Research Institute of Acupuncture and Meridian, Shanghai, China Nanjing Children’s Hospital, Nanjing Medical University, Nanjing, Jiangsu, China Graduate Division of Nutritional and Environmental Sciences, University of Shizuoka, 52-1 Yada, Shizuoka 422-8526, Japan Key Laboratory of Application and Safety Control of Genetically Modified Crops Southwest University, Rice Research Institute Chongqing 400715 People's Republic of China Institute for Clinical Medicine, The First People's Hospital of Foshan, Foshan 528000, China. |
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