http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_10a647b206a92461f52a8311454acccf
Outgoing Links
Predicate | Object |
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family-name | Sun Yan Sun |
name | Yan Sun |
given-name | Yan |
organization-name | Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125, United States Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of China Department of Anesthesiology; Qilu Hospital of Shandong University; Jinan China School of Materials Henan University Zhengzhou 450000 P. R. China Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China Department of Pediatrics Children's Hospital of Xinjiang Uygur Autonomous Region Urumqi China Department of Chemistry, University of Utah, 315 South 1400 East, Room 2020, Salt Lake City, Utah 84112, United States; School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, P. R. China Department of General Surgery, Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, P.R. China Joint Program in Transfusion Medicine, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts, USA School of Food and Health, Zhejiang Agricultural and Forestry University, Hangzhou 311300, China Reproductive Medicine Center, Fujian Maternity and Child Health Hospital Fuzhou Fujian China College of Life Science, Shaanxi Normal University, Xi’an 710119, China Texas Department of State Health Services Austin Key Laboratory of Agricultural Animal Genetics, Breeding and Reproduction, Ministry of Education, Huazhong Agricultural University, Wuhan, PR China;; College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, PR China Laboratory of Biopharmaceuticals and Molecular Pharmacology, School of Pharmaceutical Sciences, Hainan University, Haikou, Hainan 570228, China; Department of Translational Medicine, BioRay Pharmaceutical Co., Ltd, Shanghai, Xuhui 200030, China School of Pharmacy, Shenyang Medical College , Huanghe North Street 146, Shenyang 110034 , China Department of Medical Oncology; Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs; National Cancer Center/Cancer Hospital; Chinese Academy of Medical Sciences & Peking Union Medical College; China Department of Pediatrics, Peking University First Hospital Departments of Ophthalmology and Visual Sciences, Case Western Reserve University , Cleveland, Ohio, USA State Laboratory for Conservation and Utilization of Bio-resources, Yunnan University, Kunming 650091, China Department of Ophthalmology, School of Medicine, Pusan National University, Pusan, Korea *Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106; and Laboratory for Reproductive Immunology, Hospital & Institute of Obstetrics and Gynecology, Shanghai Medical College, Fudan University, Shanghai, China. Department of Otorhinolaryngology Head and Neck Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong, China Max Planck Institute for Chemical Physics of Solids 01069 Dresden Germany Department of Chemistry, Stanford University, Stanford, California 94305, and University at Albany, State University of New York, Albany, New York 12222 Sino‐French Institute for Earth System Science College of Urban and Environmental Sciences Peking University Beijing 100871 China 4Qidong Liver Cancer Institute, Qidong, People's Republic of China; School of Life Sciences, Anhui University, Hefei, Anhui, 230601, China; Key Laboratory of Human Microenvironment and Precision Medicine of Anhui Higher Education Institutes, Anhui University, Hefei, Anhui, 230601, China Joint Program in Transfusion Medicine, Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences , Beijing , China; University of Chinese Academy of Sciences , Beijing , China Department of Endocrinology, Heji Hospital Affilicated to Changzhi Medical College, Changzhi, Shanxi 046011, China School of Computer Science, University of Sydney, Sydney, NSW, Australia Department of Nephrology The Third Affiliated Hospital of Chongqing Medical University Chongqing China Department of Plant Nutrient, College of Resources and Environmental Sciences, Academy of National Agriculture Green Development, Key Laboratory of Plant-Soil Interactions, Ministry of Education, China Agricultural University , Beijing 100193 , PR China Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest of China, Shaanxi Normal University, Xi’an 710119, China Beijing University of Chinese Medicine, Beijing 100029, China. Lee Kong Chian School of Medicine, Nanyang Technological University, 59 Nanyang Drive, 636921 Singapore, Singapore. State Key Laboratory of Natural Medicines, Department of Pharmacology of Chinese Materia Medica, China Pharmaceutical University, Nanjing, China Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, The Key Laboratory of Remodeling-related Cardiovascular Disease, Ministry of Education, Chaoyang District, Beijing, China State Key Laboratory of Biogeology and Environmental Geology, School of Environmental Studies, China University of Geosciences, Wuhan 430074, China. Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100094, China; Key Laboratory of Computational Optical Imaging Technology, Chinese Academy of Sciences, Beijing 100094, China College of Chemical Engineering, Hebei United University, Tangshan 063009, P. R. China Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China School of Medicine, Shandong University of Traditional Chinese Medicine, Ji'nan, China. Department of Medical Oncology Cancer Hospital, Chinese Academy of Medical Sciences (CAMS) & Peking Union Medical College (PUMC); Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs Beijing China Department of Biochemical Engineering and Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China Molecular Medicine and Cancer Research Center, Chongqing Medical University Chongqing 400016, China. Department of Pathogen Biology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health Southern Medical University Guangzhou 510515 China Institute of Digestive Diseases, Nanfang Hospital, Southern Medical University, Guangzhou, China. [email protected] Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, 300072, China, [email protected]. Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China Department of Oncology, Division of Thoracic Neoplasms, The Second Hospital of Dalian Medical University, Dalian, Liaoning 116000, P.R. China 1Cancer Research Center and Department of Biomedical Sciences, State University of New York, University at Albany, Rensselaer, New York. BGI-Shenzhen, Shenzhen - China; Department of Biology, University of Copenhagen, Copenhagen - Denmark Laboratory of Biopharmaceutics and Molecular Pharmacology, School of Pharmaceutical Sciences Hainan University Haikou China Medical Research Institute, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China. [email protected]. Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing Tech University (NanjingTech), 30 South Puzhu Road, Nanjing 211816, China State Key Laboratory of Physical Chemistry of Solid Surfaces, iChEM, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China Department of Nursing *Department of Ophthalmology and Visual Science, Case Western Reserve University, Cleveland, OH 44106; Department of Cardiothoracic Surgery Changhai Hospital Shanghai China Beijing Key Laboratory of Drug Dependence, National Institute on Drug Dependence Peking University Beijing China Department of Chemistry and Biochemistry Queens College of the City University of New York 65-30 Kissena Blvd. Queens, NY 11367 USA; Ph.D. Program in Chemistry, the Graduate Center of the City University of New York 365 5th Ave. New York, NY 10016 USA Laboratory of Inorganic Synthesis and Preparative Chemistry, Jilin University, Changchun 130023, P.R. China Department of Biochemical Engineering; Key Laboratory of Systems Bioengineering of the Ministry of Education School of Chemical Engineering and Technology; Tianjin University; Tianjin 300072; China Department of Neurology, Qingdao Municipal Hospital, Qingdao University, Qingdao, China School of Pharmaceutical Sciences, Yunnan Key Laboratory of Pharmacology for Natural Products/College of Modern Biomedical Industry, NHC Key Laboratory of Drug Addiction Medicine Kunming Medical University Kunming China Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, United States; Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, United States; Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fudan University, Shanghai, China Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zheng Zhou, Henan - China Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, China Department of Medical Oncology Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research & The Affiliated Cancer Hospital of Nanjing Medical University Nanjing China State Key Laboratory for Mineral Deposit Research; School of Earth Sciences and Engineering, Nanjing University, Nanjing 210093, China Department of Neurology, Children's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hospital of Beijing Children's Hospital, Urumqi, Xinjiang, China Shandong Provincial Key Laboratory of Animal Biotochnology and Disease Control and Prevention, College of Animal Science and Technology, Shandong Agricultural University, Tai’an, China China Agricultural University Department of Turf Science and Engineering, College of Grassland Science and Technology, , Beijing, China , 100193 Max Planck Institute for Chemical Physics of Solids Nöthnitzer Str. 40 01187 Dresden Germany Department of Hepatobiliary Surgery, Jinshan Branch of Shanghai Sixth People's Hospital, Shanghai, China. Department of Otolaryngology-Head and Neck Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong Province, China Department of Ophthalmology, Case Western Reserve University, Cleveland, OH 44195, USA *Department of Ophthalmology and Visual Sciences, Department of Oral Biology School of Bioscience and Technology Weifang Medical University Weifang China Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Otorhinolaryngology and Head and Neck Surgery, Yuhuangding Hospital of Qingdao University, Yantai, China Herpetological Research Center, College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou 311121, China College of Plant Protection, Northwest A&F University, Yangling, Shaanxi 712100, P.R. China Cancer Institute/Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China. Department of Otorhinolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, China; Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, China Crop Resources Institute, Heilongjiang Academy of Agricultural Sciences, Harbin 150086, China Department of Rheumatology and Immunology, Third Affiliated Hospital, Southern Medical University, Guangzhou 510515, China. Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, P.R. China Key Lab of Agricultural Animal Genetics, Breeding and Reproduction of Ministry of Education, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan, China Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, United States School of Chemistry and Life Sciences Suzhou University of Science and Technology Suzhou 215009 China; Key Laboratory of Advanced Electrode Materials for Novel Solar Cells for Petroleum and Chemical Industry of China Suzhou University of Science and Technology Suzhou 215009 China Tianjin Key Laboratory of Molecular Optoelectronic Sciences; National Demonstration Center for Experimental Chemistry & Chemical engineering Education; National Virtual Simulation Experimental Teaching Center for Chemistry & Chemical engineering Education; Department of Chemistry; School of Science Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering Beihang University Beijing 100191 People's Republic of China; State Key Laboratory of Transducer Technology Chinese Academy of Sciences Shanghai 200050 People's Republic of China Department of dermatology the third people's hospital of Hangzhou Hangzhou city China Deparment of Pathology and Forensics, Dalian Medical University, No.9 West Section, Lvshun Road, Dalian 116044, China Institute of Stomotalogy, School of Stomotalogy, Weifang Medical University, Weifang 261042, China. [email protected] Jilin University Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital, Beijing Cancer Hospital and Institute, Beijing, P.R. China Medicinal Inorganic Chemistry Group, Department of Chemistry, University of British Columbia, 2036 Main Mall, Vancouver, BC, V6T 1Z1 Canada, and Centre for Magnetic Resonance, University of Queensland, Brisbane, Queensland 4072, Australia Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou 510080, China Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, National Cancer Center/Cancer Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, 100021, China Department of Biochemical Engineering and Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, People’s Republic of China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, People’s Republic of China Department of Stomatology Weifang Medical University Weifang China Department of Pediatrics, Children's Hospital of Xinjiang Uygur Autonomous Region; and State Key Laboratory of Reproductive Medicine Nanjing Medical University Nanjing Jiangsu 211166 China Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong 250021, P.R. China Department of Respiratory Diseases, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, Shandong 250014, P.R. China Graduate School, Beijing University of Chinese Medicine, Beijing 100029, China; Department of Hematology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091, China Department of Medical Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China. Department of Horticulture and Landscape Architecture, Jiangsu Agri-animal Husbandry Vocational College, Taizhou 225300, PR China Information Central, Hubei University of Medicine Shiyan China Department of Neurology, Shuguang Hospital, Shanghai University of TCM, 185, Pu-An Road, Shanghai 200021, China College of Veterinary Medicine, National Reference Laboratory of Veterinary Drug Residues (SCAU), South China Agricultural University, Guangzhou, China Beijing Key Laboratory of Applied Experimental Psychology National Demonstration Center for Experimental Psychology Education (Beijing Normal University), Faculty of Psychology, Beijing Normal University Beijing China College of Chemistry; Chemical Engineering and Materials Science; Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong; Key Laboratory of MoleCular and Nano Probes; Ministry of Education Department of Pediatric Hematology The Affiliated Hospital of Qingdao University Qingdao 266000 China Department of Chemistry and Biochemistry; Queens College of the City University of New York; Queens; USA; PhD Program in Chemistry Department of Endodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, China Department of Medical Oncology, Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, No. 17 Panjiayuan Nanli, Chaoyang District, Beijing 100021, China Department of Solid State Chemistry Max Planck Institute for Chemical Physics of Solids Dresden 01187 Germany Dalian Institute of Chemical Physics, The Chinese Academy of Sciences, Dalian 116023, China. [email protected] Authors' Affiliations: Departments of 1Bone and Soft Tissue Tumor, 2Pathology, and 3Epidemiology and Biostatistics, Tianjin Medical University Cancer Hospital and Institute, Tianjin, China; Departments of 4Pathology, 5Sarcoma Medical Oncology, and 6Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas; 7Department of Signal Processing, Tampere University of Technology, Tampere, Finland; and 8Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio; Authors' Affiliations: Departments of 1Bone and Soft Tissue Tumor, 2Pathology, and 3Epidemiology and Biostatistics, Tianjin Medical University Cancer Hospital and Institute, Tianjin, China; Departments of 4Pathology, 5Sarcoma Medical Oncology, and 6Cancer Biology, The University of Texas MD Anderson Cancer Center, Houston, Texas; 7Department of Signal Processing, Tampere University of Technology, Tampere, Finland; and 8Division of Experimental Hematology and Cancer Biology, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio Department of Pediatrics, Henan Provincial People’s Hospital, Zhengzhou, China Department of Medical Oncology, Cancer Institute (Hospital), Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021, China. HOPE School of Nursing Wuhan University Wuhan China Department of Solid State Chemistry Max Planck Institute for Chemical Physics of Solids 01187 Dresden Germany College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Provincial Key Laboratory of Clean Production of Fine Chemicals, Shandong Normal University, Jinan 250014, P. R. China Department of Organ Transplantation, Tianjin First Central Hospital, Tianjin, China (mainland) Key Laboratory of Advanced Electrode Materials for Novel Solar Cells for Petroleum and Chemical Industry of China, School of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou City, Jiangsu Province 215009, P. R. China Shanghai Center for DMPK Research, Shanghai Institute of Materia Medica, SIBS, Chinese Academy of Sciences, 555 Zuchongzhi Road, Zhangjiang Hi-Tech Park, 201203, Shanghai, China Research and Testing Laboratory Lubbock Department of Pathogen Biology, Nanjing Medical University, Nanjing 211166, China Howard Hughes Medical Institute, Departments of Physiology and Biochemistry, University of California, San Francisco, CA 94143-0725 Emergency Department, Jinan City People's Hospital Ji'nan, Shandong Province, China. School of Pharmacy, Hangzhou Normal University, Hangzhou, People’s Republic of China Max Planck Institute for Chemical Physics of Solids 01187 Dresden Germany Assisted Reproductive Technology Laboratory Fuzhou China Department of pediatrics, Peking University First Hospital, Beijing 100034, China. Clinical Pharmacy Center, Department of Pharmacy, Chinese PLA General Hospital, Beijing 100853, China School of Mechanical Engineering; Chengdu University; Chengdu 610106; China Department of Pathogen Biology Nanjing Medical University Nanjing Jiangsu P. R. China Department of General Surgery, Second Hospital, Haerbin Medical University, Haerbin, Heilongjiang Province 150086, China. [email protected] College of Animal Science and Technology, China Agricultural University, Beijing 100193, China; State Key Laboratory of Animal Nutrition and Feeding, Beijing 100193, China Shenyang National Laboratory for Materials Science, Institute of Metal Research, Chinese Academy of Science, Shenyang 110016, Liaoning, China.; School of Materials Science and Engineering, University of Science and Technology of China, Hefei, China. Frontiers Science Centre for Flexible Electronics, Xi'an Institute of Flexible Electronics (IFE) and Xi'an Institute of Biomedical Materials & Engineering, Northwestern Polytechnical University, Xi'an 710072, China Department of Surgery, Division of Urology, University of Maryland School of Medicine, Baltimore, Maryland; School of Nursing, Nanjing Medical University, Nanjing, Jiangsu, China (mainland) Diagnostics Department, Medical School of Southeast University, Nanjing 210009, People’s Republic of China Department of Comprehensive Medical Oncology Zhejiang Cancer Hospital Hangzhou China Departments of Pediatrics, Pathology, and Medicine, University of Rochester, Rochester, New York 146421; Departments of *Genitourinary Medical Oncology, From the Department of Radiotherapy, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing; and Fujian Province Cancer Hospital, Fuzhou, People's Republic of China. Beijing National Laboratory for Molecular Sciences (BNLMS), Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China Institute of Social Science Survey, Peking University, Beijing, China Department of Vascular Surgery, Provincial Hospital affiliated to Shandong University, Jinan, Shandong, China Health Services & Outcomes Research National Healthcare Group Singapore Department of Stomatology The Affiliated Hospital of Qingdao University Qingdao Shandong 266001 China; School of Stomatology Qingdao University Qingdao Shandong 266001 China Department of Biochemical Engineering, School of Chemical Engineering and Technology and Key Laboratory of Systems Bioengineering and Frontiers Science Center for Synthetic Biology (Ministry of Education) Tianjin University Tianjin China Key Laboratory of Marine Environmental Corrosion and Bio-fouling; Institute of Oceanology; Chinese Academy of Sciences; Qingdao 266071; PR China Department of Urology, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China Department of Microbiology, University of Chicago, Illinois Department of Gerontology, the First Affiliated Hospital (Y.L., R.Z., J.X., Y.S.), Nanjing Medical University, Nanjing 210029, China Department of Vascular Surgery, Shandong Provincial Hospital, Shandong University, Jinan Shandong, China Health Science Core Facility, Small Scale System Integration and Packaging Center, Binghamton University, Binghamton, NY 13902 Department of Hematology, Beijing Tiantan Hospital, Capital Medical University, 100050, Beijing, China. Soybean Research Institute of Northeast Agricultural University, Key Laboratory of Soybean Biology of Chinese Education Ministry, Harbin, China Qingdao University, School of Pharmacy, Qingdao, Shandong 266021, China The Second Clinical Medical College Zhejiang Chinese Medical University Hangzhou China Department of Physics, Guizhou University, Guiyang 550025, China. Medical School of Southeast University, Nanjing, People’s Republic of China College of Life Sciences, Shaanxi Normal University, Xi'an 710062, Shaanxi, P. R. China Department of Ophthalmology No. 411 Hospital of CPLA Shanghai 200081 People's Republic of China Department of Medical Genetics, West China Hospital Sichuan University Sichuan Chengdu 610041 China Department of Scientific Research and Education, The Fourth Affiliated Hospital Guangxi Medical University Liuzhou 545005, Guangxi, China. Department of Materials Science and Engineering, Northwestern University, Evanston, Illinois 60208, United States; Advanced Photon Source, Argonne National Laboratory, Argonne, Illinois 60439, United States Department of Chemistry; School of Chemistry and Molecular Engineering; East China Normal University; Shanghai; P. R. China Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China National Healthcare Group Health Services and Outcomes Research Unit, Singapore, Singapore Faculty of Dentistry The University of Hong Kong Hong Kong Hong Kong SAR China Shanghai Institute of Technical Physics, Chinese Academy of Science Shanghai Institute of Technical Physics College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang 050016, China. [email protected] Institute for Advanced Study Chengdu University Chengdu 610106 PR China The Department of Hematology and Oncology, The Second Hospital of Jilin University, Changchun 130041, China Department of Biochemical Engineering Key Laboratory of Systems Bioengineering School of Chemical Engineering and Technology Tianjin University Tianjin China; Collaborative Innovation Centre of Chemical Science and Engineering Tianjin China Department of Otolaryngology-Head and Neck Surgery, Affiliated Hospital of Medical College of Qingdao University, Qingdao 266003, China. [email protected] Department of Spinal Surgery, China-Japan Friendship Hospital, Beijing 100029, China. Ministry of Education Key Lab of Environmental Remediation and Ecosystem Health, College of Environmental and Resource Sciences Zhejiang University Hangzhou 310058 China; Zhejiang Provincial Key Laboratory of Agricultural Resources and Environment, College of Environmental and Resource Sciences Zhejiang University Hangzhou 310058 China Department of Bioengineering, Beihang University , Beijing 100083, China. [email protected] Department of Chemistry; Beijing Key Laboratory for Analytical Methods and Instrumentation; Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology of Ministry of Education; Tsinghua University; Beijing 100084 Department of Echocardiography, Beijing Children’s Hospital, Capital Medical University, National Center for Children’s Health, Beijing 100045, China Masonic Medical Research Institute, Utica, NY, USA Departments of Pediatrics,1 Department of Ophthalmology, the Fourth People's Hospital of Shenyang, Shenyang 110031, China. Department of Pathogen Biology Nanjing Medical University Nanjing Jiangsu China Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai, Xuhui District, China Tianjin Center for Control and Prevention of Aquatic Animal Infectious Disease, China Department of Hematology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, China; Graduate School, Beijing University of Chinese Medicine, Beijing, China Department of Pediatrics, Shandong Provincial Hospital, Shandong University, Jinan, China. State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China National Institute on Drug Dependence, Peking University, Beijing, China Amgen, Inc. Thousand Oaks CA USA Department of Chemistry, University at Albany, 1400 Washington Avenue, Albany, New York 12222, United States Contribution from the Center for Biochemistry and Biophysics, Department of Chemistry, University at Albany, State University of New York, Albany, New York 12222, and Department of Microbiology, Wing Hall, Cornell University, Ithaca, New York 14853 Department of Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, China Research Center for Molecular Medicine, Dalian University of Technology, Dalian 116023, China. The Second Ward of Colorectal Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, People's Republic of China for the Cooperative Studies Program (CSP) #572 and Million Veteran Program (MVP) University of California Departments of Physiology and Biochemistry, Howard Hughes Medical Institute , , San Francisco, San Francisco, CA 94143-0725, USA Department of Pathology, Tianjin Cancer Hospital, Tianjin 300060, China. Department of Medical Oncology Cancer Institute/Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China; National Center for Anticancer Drugs Clinical Study Beijing China; Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs Beijing China Department of Chemistry University of Utah 315 South 1400 East, Room 2020 Salt Lake City UT 84112 USA Key Laboratory of Marine Genetics and Breeding (MGB), College of Marine Life Sciences, Ocean University of China, Ministry of Education, Qingdao 266003, China Key Laboratory for Green Processing of Chemical Engineering of Xinjiang Bingtuan, School of Chemistry and Chemical Engineering, Shihezi University, Shihezi, 832003, China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology Peking University Cancer Hospital & Institute Beijing China Key Laboratory of Coastal Biology and Bioresource Utilization, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; University of Chinese Academy of Sciences, Beijing 100049, China; Shandong Saline-Alkali Land Modern Agriculture Company, Dongying 257300, China Key Laboratory of Marine Environmental Corrosion and Bio-fouling, Institute of Oceanology, Chinese Academy of Sciences, 7 Naihai Road, Qingdao 266071, China Clinical Pharmacy Laboratory, PLA Greneral Hospital Department of Chemistry, University of Utah, 315 South 1400 East, Room 2020, Salt Lake City, Utah 84112, United States Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, People's Republic of China Yan Sun, MS, RN, Wuhan University, Wuhan, China College of Chemical Engineering, North China University of Science and Technology, Tangshan City, Hebei Province 063009, People’s Republic of China; Key Laboratory of Advanced Energy Materials Chemistry (Ministry of Education), Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), College of Chemistry, Nankai University, Tianjin 300071, People’s Republic of China Beijing University of Chinese Medicine, Beijing 100029, China; Department of Orthopaedics, China-Japan Friendship Hospital, Beijing 100029, China Food and Drug Administration, Center for Tobacco Products, Office of Science , 10903 New Hampshire Ave Silver Spring, Maryland College of Chemistry & Chemical Engineering, Yangzhou University, Yangzhou 225002, China Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education, China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, P. R. China Department of Chemistry School of Science Tianjin University Tianjin China Department of Paediatrics, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Henan University People’s Hospital, Zhengzhou, People’s Republic of China Wuhan University of Technology 2 Centre for Fiber Sensing, , Wuhan 430071, People's Republic of China College of Veterinary Medicine, National Reference Laboratory of Veterinary Drug Residues (SCAU), South China Agricultural University, Guangzhou 510642, China Department of Neurology and the F. M. Kirby Neurobiology Center Boston Massachusetts USA; Neuromodulation Program and Division of Epilepsy and Clinical Neurophysiology Boston Children's Hospital, Harvard Medical School Boston Massachusetts USA National Cancer Center/National Clinical Research Center Cancer Hospital Chinese Academy of Medical Science and Peking Union Medical College Beijing China From the Department of Ophthalmology and Visual Sciences, and Department of Ophthalmology, The 900th Hospital of Joint Logistic Support Force, PLA (Clinical Medical College of Fujian Medical University, Dongfang Hopsital Affiliated to Xiamen University), Fuzhou, People’s Republic of China Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China Key Laboratory of Behavioral Science, Institute of Psychology, Chinese Academy of Sciences Qidong Liver Cancer Institute, Qidong People’s Hospital, Qidong, China Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research (Ministry of Education, China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, P. R. China Department of Obstetrics and Gynecology (Y.S., G.N.-P.), University of Washington, Seattle, Washington 98195–6460 Tianjin Key Laboratory of Advanced Functional Porous Materials, Institute for New Energy Materials & Low-Carbon Technologies, School of Materials Science and Engineering, Tianjin University of Technology, Tianjin 300384, China Department of Food Science and Engineering, School of Food Science and Engineering, Yangzhou University, Yangzhou 225127, China The Second People’s Hospital of Jinan, No. 148 Jingyi Road, Jinan 250001, China Department of Orthodontics, Dental College, Dalian Medical University, Dalian 116027, China. [email protected] Tianjin Key Laboratory of Advanced Functional Porous Materials Institute for New Energy Materials & Low‐Carbon Technologies School of Materials Science and Engineering Tianjin University of Technology Tianjin 300384 P. R. China Department of Biological Engineering and Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China School of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou City, Jiangsu Province 215009, P. R. China; Key Laboratory of Advanced Electrode Materials for Novel Solar Cells for Petroleum and Chemical Industry of China, Suzhou University of Science and Technology, Suzhou City, Jiangsu Province 215009, P. R. China Jiangsu Key Laboratory of Drug Discovery for Metabolic Disease and State Key Laboratory of Natural Medicines; China Pharmaceutical University; Nanjing 210009; China Department of Pediatric Endocrinology, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China Department of Perinatal Medicine, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100010, China; Department of Obstetrics, First Hospital of Qinhuangdao, Hebei 066000, China. Health Services and Outcomes Research; National Healthcare Group; Singapore; National Healthcare Group; Singapore Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio. Dongguan Maternal and Child Health Care Hospital, Dongguan, P.R. China Department of Neurology and F.M. Kirby Center for Neurobiology, Boston Children’s Hospital, Boston, MA 02115, USA. Department of Sport, Physical Education and Health Hong Kong Baptist University Hong Kong China Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy Tianjin Medical University Tianjin P. R. China Qilu Hospital of Shandong University, Jinan 250012, Shandong Province, China ; Affiliated Hospital of Weifang Medical University, Weifang 261000, Shandong Province, China. Heart Center Beijing Children's Hospital Capital Medical University National Center for Children’s Health Beijing China Department of Neurological Surgery, Spinal Cord and Brain Injury Research Group, Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202, USA School of Chemistry and Life Sciences Suzhou University of Science and Technology Suzhou City Jiangsu Province 215009 P.R. China College of Animal Science, Xichang University Xichang, Sichuan, China. Department of Cardiology, Zhejiang Province Rongjun Hospital, Jiaxing, Zhejiang 314000, P.R. China Changqing Drilling Company of CCDC, Xi’an 710060, China Obstetrics and Gynecology Hospital of Fudan University; The Academy of Integrative Medicine of Fudan University; Shanghai Key Laboratory of Female Reproductive Endocrine-related Diseases Department of Pathology, University Hospitals of Cleveland, Case Western Reserve University, Cleveland, Ohio 44106 Beijing University of Chinese Medicine, No. 11, North Third Ring East Road, Chaoyang District, Beijing 100029, China Cancer Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100021. Department of Pharmacology of Chinese Materia Medic China Pharmaceutical University Nanjing China Frontiers Science Center for Flexible Electronics (FSCFE), Shaanxi Institute of Flexible Electronics (SIFE) & Shaanxi Institute of Biomedical Materials and Engineering (SIBME), Northwestern Polytechnical University (NPU), 127 West Youyi Road, Xi’an 710072, China Department of Physical Education, Chang’an University, Xi’an, Shaanxi 710064, China Department of Biochemical Engineering and Key Laboratory of Systems Bioengineering of Ministry of Education; School of Chemical Engineering and Technology, Tianjin University; Tianjin China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin); Tianjin China Wuhan Institute for Neuroscience and Neuroengineering, South-Central University for Nationalities, Wuhan, Hubei, China Department of Pediatrics Peking University First Hospital College of Grassland Science and Technology, China Agricultural University, Beijing 100193, China School of Pre-Clinical Medicine, Beijing University of Chinese Medicine, Beijing 100029, China School of Mechanical Engineering Chengdu University Chengdu 610065 P. R. China Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, PR China Department of Gynecology and Obstetrics, Tianjin Medical University General Hospital, Tianjin, China; Tianjin Key Layboratory of Female Reproductive Health and Eugenics, Tianjin, China School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu 225002, P. R. China Shandong Provincial Hospital Affiliated to Shandong University, Jinan, China; Key Laboratory of Tropical Diseases and Translational Medicine of the Ministry of Education & Hainan Provincial Key Laboratory of Tropical Medicine, Hainan Medical College, Haikou , China Department of Orthodontics, Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai 200011, China. [email protected] Department of Internal Medicine, Texas Tech University Health Sciences Center, Paul L. Foster School of Medicine, El Paso, TX, USA Department of Chemistry, University at Albany, State University of New York, Albany, NY 12222 Gansu Rehabilitation Center Hospital. School of Mechanical Engineering, Chengdu University, Chengdu, Sichuan 610106, China Medical Biofilm Research Institute, Lubbock, Texas. Institute of Developmental Psychology Beijing Key Laboratory of Applied Experimental Psychology Faculty of Psychology Beijing Normal University China School of Biological Science and Medical Engineering, Beihang University, Beijing, China Department of Biochemistry and Molecular Biology Eberly College of Science The Pennsylvania State University, 219 Wartik Lab University Park PA 16802 USA Department of Biochemical Engineering and Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China Department of Medical Oncology, Cancer Hospital (Institute); Peking Union Medical College and Chinese Academy of Medical Sciences; Beijing China Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China; CAS Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao, China; Laboratory for Marine Ecology and Environmental Sciences, Qingdao National Laboratory for Marine Science and Technology, Qingdao, China Department of Pharmacy, Nantong Hospital of Traditional Chinese Medicine, Nantong, People’s Republic of China; Hangzhou Institute for Advanced Study, University of Chinese Academy of Sciences, Hangzhou, People’s Republic of China Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People's Republic of China Research and Testing Laboratory, Lubbock, Texas. Department of Microbiology, University of Chicago, Chicago, Illinois, USA Obstetrics and Gynecology Hospital of Fudan University, Shanghai 200011, China; The Academy of Integrative Medicine of Fudan University, Shanghai 200011, China; Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases, Shanghai 200011, China Department of Pathology, Department of Critical Care Medicine, National Clinical Research Center for Infectious Diseases, The Second Affiliated Hospital of Southern University of Science and Technology, Shenzhen Third People’s Hospital, Shenzhen, China. Department of Head and Neck Surgery the University of Texas MD Anderson Cancer Center Houston TX; Department of Otolaryngology‐Head and Neck Surgery Yuhuangding Hospital of Qingdao University Yantai China Laboratory of Phase I Clinical Trials Fudan University Shanghai Cancer Center Shanghai China; Department of Oncology, Shanghai Medical College Fudan University Shanghai China Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA; Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China Chinese Atomic Energy Agency Center of Excellence on Nuclear Technology Applications for Insect Control, Key Laboratory of Tropical Disease Control of the Ministry of Education Sun Yat‐sen University Guangzhou China; SYSU Nuclear and Insect Biotechnology Co., Ltd Dongguan China; International Atomic Energy Agency Collaborating Centre Sun Yat‐sen University Guangzhou China; Guangdong Provincial Engineering Technology Research Center for Diseases‐Vectors Control Sun Yat‐sen University Guangzhou China Department of Neurosurgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, P.R. China College of Pharmacy, Chongqing Medical University, Chongqing 400016, China. Department of Gastroenterology, Shengjing Hospital of China Medical University 39 Huaxiang Road, Tiexi District, Shenyang 110022, Liaoning Province, China. MOE Key Laboratory of Laser Life Science, Guangdong Provincial Key Laboratory of Laser Life Science, Guangzhou Key Laboratory of Spectral Analysis and Functional Probes, College of Biophotonics, South China Normal University, Guangzhou 510631, China Department of Food Science and Engineering, School of Food Science and Engineering, Yangzhou University, Yangzhou 225012, China General Hospital of PLA, Beijing, China. [email protected] Research Center for Frontier Fundamental Studies Zhejiang Labs Yuhang District Hangzhou Zhejiang 311121 P. R. China The Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning, PR China Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, 324, Jing 5 Road, Jinan 250021, Shandong, China Department of Radiation Oncology Key laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing) Peking University Cancer Hospital and Institute, Peking University Beijing P.R. China Max Planck Institute for Chemical Physics of Solids, Noethnitzer Strasse 40, 01187 Dresden, Germany Department of Ophthalmology The Second People's Hospital of Jinan Jinan China Emergency Department, Sichuan Academy of Medical Sciences and Sichuan Provincial People's Hospital, Chengdu, Sichuan 610072, P.R. China From the Dana-Farber Cancer Institute, Boston, MA; Oncology Center AZ St Augustinus, Antwerp; UZ Gasthuisberg, Leuven; and Institut Jules Bordet, Brussels, Belgium; Cancer Hospital, Chinese Academy of Medical Sciences; Chinese People's Liberation Army General Hospital; and The Hospital Affiliated Academy of Military Medical Science, Beijing, China; Cancer Institute of New Jersey, New Brunswick, NJ; Deenanath Mangeshkar Hospital, Pune; and Tata Memorial Hospital, Mumbai, India; Dartmouth-Hitchcock Medical... for the VA Million Veteran Program COVID-19 Science Initiative School of Clinical Medicine, Bengbu Medical College, Bengbu 233000, China. He's university Shenyang China; Shenyang He Eye Specialist Hospital Shenyang China Department of Pathology, Dalian Medical University, Liaoning 116044, P.R. China 1Department of Pediatric Hematology, The Affiliated Hospital of Qingdao University, Shandong 266003, PR China Department of Pediatrics, Peking University First Hospital, Beijing 100034, China Department of Psychiatry, Columbia University, New York, NY 10032, USA School of Art and Communication China University of Geosciences Wuhan China Department of Dermatology, The First Hospital of China Medical University, Shenyang, Liaoning, China; Department of Biochemical Engineering and Key Laboratory of Systems Bioengineering Ministry of Education School of Chemical Engineering and Technology Tianjin University Tianjin 300354 P.R. China Department of General Surgery, Jinshan Branch of Shanghai Sixth People's Hospital, Shanghai Jiaotong University Shanghai 201599, P. R. China. Institute of Physical Science and Information Technology, Anhui University, Hefei 230601, People’s Republic of China Medicinal Inorganic Chemistry Group, Department of Chemistry, University of British Columbia, Vancouver, BC, Canada V6T 1Z1 Department of Chemistry and Shenzhen Grubbs Institute; Southern University of Science and Technology; Shenzhen 518055; China Department of Pathobiology, University of Illinois at Urbana-Champaign, 2001 South Lincoln Avenue, Urbana, IL 61802, USA; Department of Pathobiology, University of Pennsylvania, 380 South University Avenue, Philadelphia, PA 19104, USA Department of Gastroenterology, Nanfang Hospital, Southern Medical University, Guangzhou, PR China. Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China School of Biological Science and Medical Engineering Beihang University, Haidian District Beijing 100191 China Department of Ophthalmology, Hongkou Branch of Changhai Hospital, Naval Medical University, Shanghai 200081, China Institutes of Physical Science and Information Technology, Anhui University, Hefei 230601, People's Republic of China Key Laboratory of Marine Ecology and Environmental Sciences Institute of Oceanology Chinese Academy of Sciences Qingdao China School of Mechanical Engineering, Chengdu University, Chengdu 610106, PR China Department of Chemistry, University at Albany—SUNY, Albany, New York 12222, and Department of Biochemistry, Molecular Biology and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455 College of Life Sciences, Shaanxi Normal University, Xian, China Department of Anesthesiology, Chengdu Second People's Hospital College of Agriculture and Biotechnology, China Agricultural University, Beijing, China Department of Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; Department of Pathology, Tianjin Medical University Cancer Institute & Hospital, Tianjin, China Department of Nephrology, The Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao, P.R. China Department of Chemistry, Stanford University, Stanford, California 94305, and Department of Chemistry, University at Albany, State University of New York, Albany, New York 12222 Department of Oncology, Jiangsu Cancer Hospital, Nanjing Medical University, Nanjing, Jiangsu 211166, China Yixing Center for Disease Control and Prevention, Yixing, Jiangsu Province, China 3Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, P.R. China. Department of Medical Genetics, West China Hospital, Sichuan University, Division of Human Morbid Genomics, State Key Laboratory of Biotherapy of Human Diseases, Chengdu, Sichuan, 610041 P. R. China. Yixing Center for Disease Control and Prevention, Yixing, China State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center Sun Yat‐sen University Guangzhou China School of Environmental Science and Engineering, Changzhou University, Changzhou 213164, China Department of Chemistry; School of Science; Tianjin University; Tianjin 300354; China School of Mechanical Engineering Chengdu University Chengdu 610106 P. R. China Department of Nursing, Shangdong Medical College. Department of Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, China; Key Laboratory of Otolaryngology-Head and Neck Surgery, Ministry of Education, Beijing, China Department of Statistics, Purdue University, West Lafayette, IN Department of Cellular Biology, Institute of Biomedicine, National engineering research center of genetic Medicine, Key laboratory of Bioengineering Medicine of Guangdong Province Jinan University Guangzhou Guangdong People's Republic of China BGI‑Wuhan, BGI‑Shenzhen, Wuhan, Hubei 430074, P.R. China National Institute on Drug Dependence Peking University China; Beijing Key Laboratory on Drug Dependence Research China Max Planck Institute for Chemical Physics of Solids, 00187 Dresden, Germany Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China; Sino-German Laboratory of Personalized Medicine for Pancreatic Cancer, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, China Department of Pathogen Biology, Guangdong Provincial Key Laboratory of Tropical Disease Research, School of Public Health Southern Medical University Guangzhou China Department of Grass and ForageScience, College of Animal Science and Technology China Agricultural University Beijing China Department of Nephrology, The Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao, China College of Urban and Environmental Sciences and Key Laboratory for Earth Surface Processes of the Ministry of Education, Peking University, Beijing 100871, China Department of Medical Genetics, West China Hospital, Sichuan University, and Division of Human Morbid Genomics, Key Laboratory of Biotherapy of Human Diseases, Ministry of Education, Chengdu 610041,China. [email protected] The Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning, China Department of Pharmacy, The Second People's Hospital of Dongying Dongying, Shandong Province, China. Department of Otolaryngology—Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, P.R. China Department of Radiation Oncology Peking University School of Oncology Beijing People's Republic of China Department of Social Medicine and Health Management School of Public Health Jilin University Changchun China; The First Hospital of Qiqihar City Qiqihar China Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs Beijing China Institute of Physical Science and Information Technology, Anhui University, Hefei 230601, P. R. China Department of Endodontics, School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou 325027, China Department of Biochemical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China National Laboratory for Infrared Physics, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, China; University of Chinese Academy of Science, Beijing 100049, China Department of Medical Oncology Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China Department of Ophthalmology and the Visual Sciences Research Center, Case Western Reserve University School of Medicine, University Hospitals Case Medical Center, Cleveland, Ohio, USA 44106. Dongguan Maternal and Child Health Care Hospital Dongguan China State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin 150090, China Department of Gastroenterology, Ruijin Hospital, School of Medicine, Shanghai Jiao Tong University Institute of Environment and Architecture, University of Shanghai for Science and Technology, Shanghai 200093, People's Republic of China Grassland Science Department, College of Animal Science and Technology China Agricultural University Beijing China Department of Pediatrics Shandong Provincial Hospital Shandong University Jinan Shandong 250021 China CAS Key Laboratory of Marine Environmental Corrosion and Bio-fouling; Institute of Oceanology; Chinese Academy of Science; Qingdao 266071; China Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China Key Laboratory of Gastroenterology of Zhejiang Province, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College) , Hangzhou, Zhejiang, P. R. China Guangdong Provincial Key Laboratory of Food, Nutrition and Health, Department of Nutrition, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China School of Food Science and Engineering, Shaanxi University of Science & Technology, Xi'an 710021, P. R. China Center for Asthma and Allergy Immunotherapy, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou , P.R. China Department of Chemistry and Biochemistry, Queens College of the City University of New York, 65-30 Kissena Blvd., Queens, New York 11367, United States; Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, 365 5th Avenue, New York, New York 10016, United States Children's Hospital Boston, Harvard Medical School, Boston, Massachusetts 02115, USA Department of Nutrition and Food Hygiene, School of Public Health, Hebei Medical University, Hebei Key Laboratory of Environment and Human Health, Shijiazhuang, People’s Republic of China Department of Endocrinology, Southern University of Science and Technology Hospital, Shenzhen, P.R. China School of Physical Education, East China JiaoTong University, Nanchang 330013, China. Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, P.R. China Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106 Department of Psychology Beijing High School #19 Beijing China; Faculty of Psychology Beijing Normal University Beijing China From the Rigshospitalet, Copenhagen, Denmark; Petrov Research Institute of Oncology, St Petersburg, Russia; Chinese Academy of Medical Sciences, Beijing, China; Hospital Universitario de la Princesa, Madrid, Spain; Arcipedale Santa Maria Nuova, Reggio Emilia, Italy; Centre Hospitalier Général André-Boulloche, Montbéliard, France; University of Stellenbosch, Cape Town, South Africa; South Carolina Oncology Associates, Columbia, SC; Ziekenhuis Leyenburg, Den Haag, the Netherlands; University of Hamburg,... Department of Radiotherapy Peking University Cancer Hospital & Institute Beijing China Institute of Crop Science, Chinese Academy of Agricultural Sciences Department of Epidemiology, Emory University, Atlanta, GA Department of Pathology Tianjin Medical University Cancer Institute and Hospital Tianjin 300060 PR China; Department of Pathology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA Department of Pharmacy, Hospital of Luzhong Mining Co., Ltd., Jinan, China. Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, United States Department of Reproductive Medicine (A.S.K., J.K., A.R.K.), University of California, San Diego, La Jolla, California;; Department of Obstetrics/Gynecology and Women's Health (Y.S., J.S., G.N.-P., Albert Einstein College of Medicine, Bronx, New York; Changli Research Institute of Fruit Trees, Hebei Academy of Agricultural and Forestry Sciences, Changli 066600, China Department of Chemistry, University of Utah, Salt Lake City, UT 84112; Veterans Research and Education Foundation, VA Medical Center, Oklahoma City, Oklahoma; Neurological intensive care unit Special medical center of PAP Tianjin China Dairy Cattle Research Center, Shandong Academy of Agricultural Science, Jinan 250131, China. Department of Energy Science, Sungkyunkwan University, Suwon 16419, Republic of Korea Department of Hematology, The Affiliated Hospital of Qingdao University , No. 1677 of Wutaishan Road, Huangdao District , Qingdao 266000, Shandong , China Administrative Office, The Reproductive Hospital of Guangxi Zhuang Autonomous Region , Nanning, Guangxi Zhuang Autonomous Region , P.R. China Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical Center for Coronary Heart Disease, Capital Medical University, Beijing100029, China Department of Pathology, Tianjin Cancer Hospital and Institute, Tianjin Medical University Department of Obstetrics and Gynecology, Zhangjiagang Hospital of Traditional Chinese Medicine and Affiliated Zhangjiagang Hospital of Nanjing University of Chinese Medicine , Zhangjiagang 215600 , China Department of Biological Sciences, Guangdong Province Key Laboratory for Biotechnology Drug Candidates, College of Life Science and Biopharmaceutics, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510080, P.R. China Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, 610041, Sichuan, China Department of Digestive Internal Medicine, First Hospital of Qinhuangdao, Hebei, P.R. China. Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China. Amgen Inc, Thousands Oaks, CA Department of Clinical Psychology Kailuan Mental Health Center Affiliated to North China University of Science and Technology Tangshan Hebei China Department of Emergency Medicine Lianyungang Clinical College of Nanjing Medical University Lianyungang China Department of Chemistry; University of Utah; Salt Lake City; USA; College of Chemistry and Chemical Engineering State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China Antonio C. Wolff, the Johns Hopkins Kimmel Comprehensive Cancer Center, Baltimore, MD; Ann A. Lazar, University of California San Francisco, San Francisco, CA; Igor Bondarenko, Municipal Clinical Hospital #4, State Medical Academy, Dnepropetrovsk, Ukraine; August M. Garin, Russian Oncological Research Center, Moscow, Russia; Stephen Brincat, Sir Paul Boffa Hospital, Floriana, Malta; Louis Chow, UNIMED Medical Center, Wan Chai, Hong Kong; Yan Sun, Cancer Hospital, Chinese Academy of Medical Sciences,... University of California Howard Hughes Medical Institute and Departments of Physiology and Biochemistry , , San Francisco, San Francisco, CA 94143-0724, USA Department of Ophthalmology, The Jinan Second People’s Hospital, Jinan, China Department of Neurology, Children's Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hospital of Beijing Children's Hospital, Urumqi, Xinjiang, China. Key Laboratory of Marine Environmental Corrosion and Bio-fouling; Institute of Oceanology; Chinese Academy of Sciences; Qingdao 266071, China Department of Psychiatry, First Hospital of Shanxi Medical University, Taiyuan, People's Republic of China. Tianjin Medical University First Center Clinical College, Tianjin 300192, China. Department of Transplantation, Tianjin First Center Hospital, Tianjin 300192, China. Department of Orthodontics, Ninth People's Hospital, School of Stomatology, Shanghai Second Medical University, China. [email protected] Department of Dermatology Changzhou Hospital of Traditional Chinese Medicine Changzhou China School of Information Science and Engineering, Qufu Normal University, Rizhao 276826, China State Key Laboratory of Bioreactor Engineering East China University of Science and Technology Shanghai China Department of Pediatrics, Shandong Provincial Hospital Affiliated to Shandong University, Jinan, Shandong, China Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China Department of Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China School of Environmental Science and Engineering; Qilu University of Technology (Shandong Academy of Sciences); Jinan 250353; China Key Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin 150040, People’s Republic of China Faculty of Psychology Beijing Normal University China Department of Emergency and Oral Medicine, School of Stomatology, China Medical University, Shenyang, Liaoning 110001, P.R. China Department of Radiation Oncology Key Laboratory of Carcinogenesis and Translational Research, Ministry of Education, Peking University Cancer Hospital & Institute Beijing China Department of Gynaecology and Obstetrics, General Hospital of Zaozhuang Mining Group, Zaozhuang, Shandong 277000, P.R. China National Institute on Drug Dependence, Peking University, Beijing, China. Department of Medical Oncology, Chinese Academy of Medical Sciences Cancer Institute and Hospital, Beijing, China MOE Key Laboratory of Xinjiang Endemic and Ethnic Diseases/Department of Pathology, School of Medicine, Shihezi University, Shihezi, Xinjiang, P. R. China. Department of Pharmacology, School of Basic Medical Sciences Peking University Health Science Center Beijing China; National Institute on Drug Dependence Peking University Beijing China Department of Pediatric, Shandong Provincial Hospital Affiliated to Shandong First Medical University , Jinan 250021, Shandong , China Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China Department of Clinical Pathogenic Microorganism, Qiqihar Medical University, Qiqihar 161006, China Department of Comprehensive Medical Oncology, Cancer Hospital of the University of Chinese Academy of Sciences, Hangzhou, China. Department of Toxicology; College of Public Health; Harbin Medical University; Harbin; P. R. China Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA Max Planck Institute for Chemical Physics of Solids, Nöthnitzer Str. 40, 01187 Dresden, Germany. Corresponding author. Department of Pediatrics People's Hospital of Xinjiang Uygur Autonomous Region Urumqi China Department of Clinical Pathogen Microbiology, Qiqihar Medical University, Qiqihar, Heilongjiang, 161006, China Tianjin University Department of Biochemical Engineering and Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, , Tianjin 300072, China Department of Otolaryngology Head and Neck Surgery,Beijing Tongren Hospital,Capital Medical University,Beijing,100730,China. Department of Pancreatic Surgery, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China; Sino‐German Laboratory of Personalized Medicine for Pancreatic Cancer, Union Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China Key Laboratory for Special Functional Materials of Ministry of Education, School of Materials Science and Engineering, Collaborative Innovation Center of Nano Functional Materials and Applications, Henan University, Zhengzhou 450046, China Department of Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, P.R. China Department of Otolaryngology–Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing Institute of Otolaryngology, Key Laboratory of Otolaryngology, Head and Neck Surgery, Ministry of Education, Beijing, China Yan Sun, Lian-Jie Lin, Chang-Qing Zheng, Department of Gastroenterology, Shengjing Hospital of China Medical University, Shenyang 110022, Liaoning Province, China. Beihang University; Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education 1 School of Biological Science and Medical Engineering, , Beijing 100191, China Department of Chemistry School of Chemistry and Molecular Engineering East China Normal University Shanghai 200241 P. R. China Cancer Hospital Chinese Academy of Medical Sciences Beijing China NYC Health & Hospital, South Brooklyn Health, Brooklyn, New York, USA Email: [email protected] ORCID iD: 0000-0002-9687-3599 Lishui Municipal Central Hospital, Lishui 323000, Zhejiang Province, China. Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing 100191, China Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China College of Horticulture, Northwest A & F University, Yangling 712100, China. [email protected] Department of Pharmaceutics, General Hospital of PLA, Beijing 100853, China. School of Mechanical Engineering, Chengdu University, Chengdu 610106, China College of Urban and Environmental Sciences, and Key Laboratory for Earth Surface Processes of the Ministry of Education Peking University Beijing China Department of Ultrasonography, Qilu Hospital, Shandong University, Qingdao, Shandong 266035, P.R. China BGI-Shenzhen, Shenzhen, China From the 1Center for Medical Mycology, Department of Dermatology, Case Western Reserve University, Cleveland, Ohio; Shandong Provincial Institute of Dermatology & Venereology, Jinan, Shandong, China; and 3Department of Ophthalmology and Visual Sciences, C School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China Alfredo Carrato, Ramon y Cajal University Hospital, Madrid, Spain; Anna Swieboda-Sadlej and Marzanna Staszewska-Skurczynska, Samodzielny Publiczny Centralny Szpital Kliniczny, Warsaw, Poland; Robert Lim, National University Health System, National University of Singapore, Singapore; Laslo Roman, Leningrad Regional Oncology Centre, St. Petersburg, Russian Federation; Yaroslav Shparyk, Lviv State Oncologic Regional Treatment and Diagnostic Center, Lviv; Igor Bondarenko, City Multiple-Discipline Clinical... National Laboratory for Infrared Physics, Shanghai Institute of Technical Physics, Chinese Academy of Sciences, Shanghai 200083, China Max‐Planck Institute for Chemical Physics of Solids Nöthnitzer Str. 40 01187 Dresden Germany Laboratory of DMPK Research of Herbal Medicines, Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai China Key Laboratory of Advanced Electrode Materials for Novel Solar Cells for Petroleum and Chemical Industry of China, Suzhou University of Science and Technology, Suzhou City, Jiangsu Province 215009, China School of Mechanical Engineering, Chengdu University, Chengdu610106, P. R. China Department of Surgery, the 2nd Affiliated Hospital, Harbin Medical University, Harbin, Heilongjiang 150081, People's Republic of China Department of Ophthalmology and Visual Sciences, Case Western Reserve University , Cleveland, Ohio , USA Department of Neurology, Children’s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA. The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, P.R. China Department of Pediatrics, Peking University First Hospital, Beijing 100034, China. College of Agriculture and Biotechnology, China Agricultural University, 2 Yuanmingyuan West Road, Beijing, China Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, People's Republic of China Key Laboratory for Earth Surface Processes of the Ministry of Education College of Urban and Environmental Sciences Peking University Beijing 100871 China Department of Chemistry and Biochemistry, Queens College of the City University of New York, 65-30 Kissena Boulevard, Queens, New York 11367, United States; Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, 365 Fifth Avenue, New York, New York 10016, United States School of Chemistry and Chemical Engineering, Yangzhou University , Yangzhou 225009 , China Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430022, China. Sino-German Laboratory of Personalized Medicine for Pancreatic, Cancer Union Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan 430022, China. Department of Immunology, University of Texas M.D. Anderson Cancer Center, Houston, TX 77030 Department of Ultrasound, The Second Affiliated Hospital of Kunming Medical University, Kunming, China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong University Shanghai 200240 P. R. China National Laboratory for Infrared Physics Shanghai Institute of Technical Physics Chinese Academy of Sciences Shanghai 200083 P. R. China Key Laboratory of Chemical Biology & Traditional Chinese Medicine Research (Ministry of Education, China), College of Chemistry and Chemical Engineering, Hunan Normal University, Changsha 410081, P. R. China; Department of Chemistry, Beijing Key Laboratory for Analytical Methods and Instrumentation, Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology of Ministry of Education, Tsinghua University, Beijing 100084, P. R. China School of Mechanical Engineering, Chengdu University, Chengdu 610106, Sichuan, China Smart Nuclide Biotech, Suzhou 215123, P.R. China Department of Pharmacology and Molecular Sciences, Johns Hopkins University School of Medicine, WBSB 314, 725 North Wolfe Street, Baltimore, Maryland 21205, United States Department of Medicine, Case Western Reserve University School of Medicine, and University Hospital of Cleveland, 10900 Euclid Avenue, Cleveland, OH 44106-4982 Department of Obstetrics, Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, People's Republic of China. College of Basic Medical Sciences Shenyang Medical College Shenyang China; Lunar and Planetary Science Laboratory MUST‐Partner Laboratory of Key Laboratory of Lunar and Deep Space Exploration, CAS Macau China; State Key Laboratory of Robotics Shenyang Institute of Automation, Chinese Academy of Sciences Shenyang China Department of Chemistry, University of Utah, Salt Lake City, UT 84112 Institute of Medical Innovation and Research, Peking University Third Hospital, Beijing, China Department of Pediatric Endocrinology Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan Shandong China Tianjin Key Laboratory of Molecular Optoelectronic Sciences National Demonstration Center for Experimental Chemistry & Chemical engineering Education National Virtual Simulation Experimental Teaching Center for Chemistry & Chemical Engineering Education Department of Chemistry School of Science Tianjin University Tianjin 300354 P. R. China College of Life Science, Shaanxi Normal University, Xi’an 710062, P.R. China Department of Chemistry and Biochemistry, Queens College of the City University of New York, 65-30 Kissena Blvd., Queens, New York 11367, United States; Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, 365 Fifth Ave., New York, New York 10016, United States AbbVie, Inc. North Chicago IL U.S.A. Department of Oral Pathology, Nihon University School of Dentistry at Matsudo, Chiba 271-8587, Japan †Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, Ohio, 44106; Department of Emergency Medicine, First People’s Hospital of Lianyungang, Hospital of the Clinical Medical School of Nanjing Medical University, Lianyungang 222002, China Department of Hematology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing 100091,China. *Department of Rheumatology and Immunology, The Third Affiliated Hospital, Southern Medical University, Guangzhou 510630, China;; †Institute of Clinical Immunology, Academy of Orthopedics of Guangdong Province, Guangzhou 510630, China; School of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou 215009, China; Key Laboratory of Advanced Electrode Materials for Novel Solar Cells for Petroleum and Chemical Industry of China, Suzhou University of Science and Technology, Suzhou 215009, China Masonic Medical Research Institute 2150 Bleecker St Utica NY 13501 USA Department of Surgery, Division of Urology and Department of Cardiology, 12th ward, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical Center for Coronary Heart Disease, Capital Medical University, Beijing, China Department of Pediatrics, Peking University First Hospital, Beijing, 100034, China College of Traditional Chinese Medicine and College of Integrated Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, China; Key Laboratory of Integrative Biomedicine for Brain Diseases, College of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, China Department of Ophthalmology Jinan Second People's Hospital Jinan China Tianjin Institute of Urology; Department of Urology; The 2nd Hospital of Tianjin Medical University; Tianjin 300211; P. R. China School of Textile Science and Engineering Key Laboratory of Functional Textile Material and Product of the Ministry of Education Xi'an Polytechnic University Xi'an Shaanxi 710048 China University of Illinois at Chicago 851 South Morgan Street Chicago IL 60607 U.S.A. Department of Biochemical Engineering and Key Laboratory of Systems Bioengineering of Ministry of Education; School of Chemical Engineering and Technology; Tianjin University; Tianjin China Department of Pathology University of Texas MD Anderson Cancer Center Houston TX USA; Department of Pathology Tianjin Medical University Cancer Institute and Hospital People's Republic of China College of Pharmacy, Hunan University of Chinese Medicine, Changsha 410000, China Department of Biochemical Engineering and Key Laboratory of Systems Bioengineering of the Ministry of Education School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China Qingdao University, School of Pharmacy, Shandong, China Department of Vascular Surgery, Weifang People’s Hospital, Weifang, Shandong, China (mainland) College of Life Sciences, Shaanxi Normal University, Xi’an 710119, China Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Department of Radiation Oncology, Peking University Cancer Hospital and Institute, Beijing, People’s Republic of China Yan Sun, MD, RN, Jilin University, Changchun, China; The First Hospital of Qiqihar City, Qiqihar, China Interdisciplinary Institute for Personalized Medicine in Brain Disorders, Jinan University, Guangzhou 510632, China From the Rigshospitalet, Copenhagen, Denmark; Petrov Research Institute of Oncology, St Petersburg, Russia; Chinese Academy of Medical Sciences, Beijing, China; Hospital Universitario de la Princesa, Madrid, Spain; Arcipedale Santa Maria Nuova, Reggio Emilia, Italy; Centre Hospitalier General Andre-Boulloche, Montbeliard, France; University of Stellenbosch, Cape Town, South Africa; South Carolina Oncology Associates, Columbia, SC; Ziekenhuis Leyenburg, Den Haag, the Netherlands; University of Hamburg,... Department of Otorhinolaryngology, Affiliated Hospital of Medical College of Qingdao University, Qingdao 266003, China. [email protected] Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, Harbin, P.R. China Department of Neurology, Xinjiang Hospital of Beijing Children's Hospital, Children's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China. State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, National Research Center for Translational Medicine, Ruijin Hospital affiliated with Shanghai Jiao Tong University School of Medicine, 200025 Shanghai, China; Department of Otorhinolaryngology Cervical Surgery, Yantai Yuhuangding Hospital, Yantai Shandong, 264000, P. R. China. [email protected] Department of Molecular Medicine and Cancer Research Center, Chongqing Medical University , Chongqing , China Department of Anatomy, Histology and Embryology School of Basic Medical Sciences, Fudan University Shanghai 200032 China School of Environmental Science and Engineering, Changzhou University, Changzhou 213164, Jiangsu, P. R. China Department of Hematology and Oncology, The Second Hospital of Jilin University, Changchun, Jilin Department of Biochemistry and Molecular Biology, The Key Laboratory of Neurobiology and Vascular Biology, China Administration of Education, Hebei Medical University, Shijiazhuang 050017, China Department of Medical Oncology Fudan University Shanghai Cancer Center Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China He University, Shenyang, China College of Chemistry & Chemical Engineering Yangzhou University Yangzhou 225002 China Department of Emergency and Oral Medicine, School and Hospital of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang, Liaoning 110002, P.R. China State Key Laboratory of Marine Coatings, Qingdao 266071, China; Marine Chemical Research Institute Co., Ltd., Qingdao 266071, China Department of Pediatrics, People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi 830001, China. School of Basic Medical Sciences Tianjin Medical University Tianjin China Department of Chemistry and Biochemistry, Queens College of the City University of New York, 65-30 Kissena Blvd., Queens, New York 11367, United States; Ph.D. Program in Chemistry, The Graduate Center of the City University of New York, 365 Fifth Avenue, New York, New York 10016, United States School of Mechanical Engineering, Chengdu University, Chengdu, 610106, China State Key Laboratory of Microbial Resources, State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences , Beijing, Hebei, China; Microbial Resource and Big Data Center, Microbial Resource and Big Data Center, Institute of Microbiology, Chinese Academy of Sciences , Beijing, Hebei, China Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi’an Jiaotong University School of Chemistry and Life Sciences Suzhou University of Science and Technology Suzhou City Jiangsu Province 215009 China; Key Laboratory of Advanced Electrode Materials for Novel Solar Cells for Petroleum and Chemical Industry of China Suzhou University of Science and Technology Suzhou City Jiangsu Province 215009 China Department of Medical Oncology Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs National Cancer Center / Cancer Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China Department of Mathematics & Statistics, Utah State University, 3900 Old Main Hill, Logan, UT 84322, USA National Institute on Drug Dependence Peking University Beijing China; Beijing Key Laboratory on Drug Dependence Research, Peking University Beijing China Department of Statistics, Purdue University, 250 N. University St., West Lafayette, Indiana 47906, U.S.A Department of Endocrinology and Central Laboratory, Xuzhou Central Hospital, Xuzhou Institute of Medical Sciences, Xuzhou Institute of Diabetes; The Clinical School of Xuzhou Medical University; The Affiliated Xuzhou Central Hospital of Nanjing University of Chinese Medicine; The Affiliated Xuzhou Hospital of Medical College of Southeast University, Jiangsu, China. Department of Oncology, The Seventh Affiliated Hospital of Yangzhou University, Jingjiang People’s Hospital, Taizhou, Jiangsu, China Department of Pediatric Endocrinology , Shandong Provincial Hospital affiliated to Shandong First Medical University , Jinan , Shandong , China School of Mechanical Engineering Chengdu University Chengdu 610106 China State Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Jiangsu Engineering Research Center for Plant Genome Editing, National Observation and Research Station of Rice Germplasm Resources Nanjing Agricultural University Nanjing China From the Department of Biochemistry and Molecular Biology, The Key Laboratory of Neural and Vascular Biology, Ministry of Education of China, Hebei Medical University (Y.S., Z.Y., B.Z., X.-h.Z., M.-l.Z., X.-s.Z., H.-y.Z., J.-k.W.); Department of Urology, The Second Hospital of Hebei Medical University, China (Z.Y.); and Department of Cardiovascular Sciences, University of Leicester, United Kingdom (T.S.). State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China Department of Thoracic Surgery, General Hospital of Zaozhuang Mining Group, Shandong, Zaozhuang, China. Department of Gynecology, The First People's Hospital of Lianyungang Lianyungang, China. Department of Etiology, Qidong Liver Cancer Institute, Jiangsu, China. Department of Biochemical Engineering and Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Tianjin 300072, China Department of Peripheral Vascular (Wound Repair), Chongqing Traditional Chinese Medicine Hospital, Chongqing 400021, China Department of Pediatric and Preventive Dentistry Institute of Stomatology Weifang Medical University Weifang City China Department of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China Department of Dermatology, The First Hospital of China Medical University; Department of Plastic, Reconstructive and Aesthetic Surgery, Nippon Medical School Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China; College of Chemistry and Material Science, Hebei Normal University, Shijiazhuang, 050016, P. R. China Department of Cell Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China; Department of Biochemistry, Western University , London, ON, N6G 2V4, Canada; Department of Computer Science, University of Manitoba , Winnipeg, MB, R3T 2N2, Canada; Department of Computer Science, Western University , London, ON, N6G 2V4, Canada Engineering and Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province, Lanzhou Institute of Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences (CAAS), Lanzhou, China. 3Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center of Cancer, Tianjin, China. Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang, China 6Department of Cancer Systems Imaging, The University of Texas M.D. Anderson Cancer Center, Houston, Texas. National Center for STD/AIDS Prevention and Control, Chinese Center for Disease Control and Prevention, Beijing, China. College of Marine Life Sciences, Ocean University of China, Qingdao, China Department of Oncology, Qinhuangdao First People's Hospital, Qinhuangdao, Hebei 066000, P.R. China Department of Urology, Tianjin Institute of Urology, Second Hospital of Tianjin Medical University, Tianjin, People's Republic of China. Department of Clinical Pathogen, Medical Technology College, Qiqihar Medical University, Qiqihar, China Department of Obstetrics/Gynecology and Women's Health, Albert Einstein College of Medicine, Bronx, New York; and Department of Chemistry, Zhejiang Normal University, 688 Yingbin Road, Jinhua 321004, China Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Respiratory Medicine and critical care, The First Affiliated Hospital of Shandong First Medical University & Shandong Provincial Qianfoshan Hospital, 16766 Jingshi Road, Lixia, 250014, Jinan, Shandong, P.R. China Department of Radiology, West China Second Hospital, Sichuan University, Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China Department of Diagnostic Ultrasound, The Fouth Hospital of Jinan Jinan, Shandong, China. Department of Chemistry, Michigan State University, East Lansing, Michigan 48824, United States Veterans Research and Education Foundation, Veterans Affairs Medical Center, Oklahoma City, Oklahoma; Department of Cardiovascular Functional Studies, China Meitan General Hospital, Beijing 100028, China Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. China Department of Paediatrics, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan Department of Pathogen Biology Nanjing Medical University Nanjing China Department of Cardiology, People's Hospital of Xuyi, Xuyi 211700, Jiangsu, P.R. China Department of Pediatrics, Peking University First Hospital, Beijing, China Laboratory of Viral and Gene Therapy, Eastern Hepatobiliary Surgical Hospital, The Second Military Medical University, Shanghai, China. Department of Dermatology, No. 1 Hospital of China Medical University, Shenyang, China. Department of Nephrology the Affiliated Qingdao Municipal Hospital of Qingdao University Qingdao P.R. China Department of Etiology, Qidong Liver Cancer Institute, Qidong Jiangsu Province 226200, China. Department of Oral Biology, Weifang Medical University, Weifang, Shandong 261053, P.R. China Max Planck Institute for Chemical Physics of Solids, Dresden D-01187, Germany. Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, P.R. China Department of Chemistry, University of Utah, Salt Lake City, UT 84112; Ministry of Education Key Laboratory for Special Functional Materials, Henan University, Kaifeng 475004, China Institute of Eco-environmental and Soil Sciences, Guangdong Academy of Sciences, Guangzhou, China Amgen, Inc., Thousand Oaks, CA, USA School of Rehabilitation Medicine, He'nan University of Chinese Medicine Zhengzhou, He'nan Province, China. Tianjin University 1 Department of Biochemical Engineering and Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, , Tianjin 300072, China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) 2 , Tianjin 300072, China Cancer Cluster National Institute on Minority Health and Health Disparities National Institutes of Health Bethesda MD USA; Laboratory of Biochemistry and Genetics National Institute of Diabetes and Digestive and Kidney Diseases National Institutes of Health Bethesda MD USA National Healthcare Group Singapore Singapore School of Chemistry and Chemical Engineering, Zhangjiang Institute for Advanced Study, Frontiers Science Center for Transformative Molecules, State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong University Shanghai 200240 China 1Department of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi Province, China. Department of Phase I Clinical Trial Zhejiang Cancer Hospital, Hangzhou Institute of Medicine (HIM), Chinese Academy of Sciences Hangzhou Zhejiang China; Postgraduate training base Alliance of Wenzhou Medical University Zhejiang Cancer Hospital Hangzhou Zhejiang China Department of Pediatrics, Provincial Hospital Affiliated to Shandong University, Jinan 250021, China. Department of Otolaryngology, Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, PR China; Shandong Provincial Clinical Research Center for Otorhinolaryngologic Diseases, Yantai, Shandong, PR China Chinese Academy of Inspection and Quarantine, Beijing 100176, China. School of Food Science and Technology, Dalian Polytechnic University, Dalian 116034, China. Laboratory of Biopharmaceuticals and Molecular Pharmacology, School of Pharmaceutical Sciences, Hainan University, Haikou 570228, China Cancer Research Center, Department of Biomedical Sciences, State University of New York, University at Albany, Rensselaer, NY 12144, USA Pharmaceutical College & Key Laboratory of Pharmacology for Natural Products of Yunnan Province, Kunming Medical University, Kunming Yunnan, 650500, China. Key Laboratory of Bio-active Peptides of Yunnan Province/Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences, Kunming Institute of Zoology, Kunming Yunnan, 650032, China. the Traumatology of Emergency Department, the First People's Hospital of Yunnan Province/the Affiliated Hospital of Kunming University of Science and Technology, Kunming Yunnan, 650032, China. College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China Ministry of Education Key Laboratory of Marine Genetics and Breeding, College of Marine Life Sciences, Ocean University of China, Qingdao, People's Republic of China Department of Nephrology, The Third Affiliated Hospital of Chongqing Medical University, Chongqing, China Beijing Institute of Technology 1 Department of Physics, , Beijing 100081, People's Republic of China; Beijing Institute of Technology 2 Key Laboratory of Cluster Science of Ministry of Education, , Beijing 100081, People's Republic of China Department of Sport Physical Education and Health, Hong Kong Baptist University Hong Kong China Key Laboratory for Biobased Materials and Energy, Ministry of Education, South China Agricultural University, Guangzhou, Guangdong 510640, China; College of Materials and Energy, South China Agricultural University, Guangzhou, Guangdong 510640, China Center of Experimental Animals, Sun Yat-sen University, Guangzhou 510080, Guangdong Province, China. Department of Anesthesiology China‐Japan Union Hospital of Jilin University Changchun China Department of Child Healthcare, Wuxi Children’s Hospital, Wuxi, Jiangsu, P.R. China Department of Ophthalmology, Lanzhou Purui Ophthalmology Hospital, Lanzhou, China; Department of Ophthalmology, Gansu Rehabilitation Center Hospital, Lanzhou, China; Clinical School of Traditional Chinese, Gansu University of Chinese Medicine, Lanzhou, China Center of Basic Medical Research Institute of Medical Innovation and Research Peking University Third Hospital Beijing 100191 China; Cancer Center of Peking University Third Hospital Beijing 100191 China Key Laboratory of Marine Ecology and Environmental Sciences, Institute of Oceanology, Chinese Academy of Sciences, Qingdao, China Department of Geriatrics, Zhongshan Hospital, Fudan University, Shanghai 200032, China Department of Radiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou 215008, China Research and Testing Laboratory, Lubbock, TX, USA. Department of Medical Oncology, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China Center of Biomedical Research Excellence (COBRE) in Stem Biology and Regenerative Medicine, Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, Scarborough Department of Clinical Trial The Cancer Hospital of the University of Chinese Academy of Sciences (Zhejiang Cancer Hospital) Hangzhou China; Institute of Basic Medicine and Cancer (IBMC), Chinese Academy of Sciences Hangzhou China School of Chemistry and Chemical Engineering Zhangjiang Institute for Advanced Study Frontiers Science Center for Transformative Molecules State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong University Shanghai 200240 P. R. China Department of West China School of Medicine Sichuan University Chengdu China Microbiological Laboratory Cardiovascular Institute The First Affiliated Hospital Harbin Medical University China Health Management Center Affiliated Hospital of Yangzhou University Yangzhou China Department of Dermatology; The First Hospital of China Medical University; Shenyang China Department of Chemistry; School of Chemistry and Molecular Engineering; East China Normal University; Shanghai; P.R. China College of Animal Science and Technology China Agriculture University Beijing 100193 China Department of Otolaryngology–Head and Neck Surgery, Yantai Yuhuangding Hospital, Qingdao University, Yantai, Shandong, China Institute of Materia Medica, Chinese Academy of Medical Science and Peking Union Medical College, Beijing, China Max-Planck-Institute für Chemische Physik Fester Stoffe, 01187 Dresden, Germany Department of Reproductive Medicine, Dongguan Maternal & Child Healthcare Hospital, Dongguan 523000, China Department of Orthodontics, College of Stomatology, Ninth People's Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 20001, China. AbbVie Stemcentrx LLC, South San Francisco, California, USA Max-Planck-Institut für Chemische Physik fester Stoffe, 01187 Dresden, Germany. Forage Seed Laboratory, College of Grassland Science and Technology China Agricultural University Beijing China Department of Chemistry; Zhejiang Normal University; Jinhua 321004; China Department of Pathology Jilin Cancer Hospital Changchun 130012 China Department of Gastroenterology, Zhejiang Provincial People’s Hospital (Affiliated People’s Hospital, Hangzhou Medical College), Hangzhou, Zhejiang, P.R. China Apoptosis, Cancer, and Development Laboratory, Equipe labellisée ‘La Ligue’, LabEx DEVweCAN, Centre de Recherche en Cancérologie de Lyon, INSERM U1052-CNRS UMR5286, Centre Léon Bérard, Université de Lyon, Université Claude Bernard Lyon1, 69008 Lyon, France; Pathology, Tianjin Medical University Cancer Hospital and Institute, Tianjin, 30060, China Department of General Surgery, Second Affiliated Hospital of Harbin Medical University, Harbin, China. Department of Ultrasonography, Anzhen Hospital, Capital Medical University, Beijing 100029, China. 3Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, P.R. China. Division of Reproductive Endocrinology and Infertility Department of Obstetrics and Gynecology University of Wisconsin‐Madison Madison WI USA; Reproductive Medicine Center Fujian Provincial Maternity and Children’s Hospital Affiliated Hospital of Fujian Medical University Fuzhou Fujian China Department of Pathology, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer; Key Laboratory of Cancer Prevention and Therapy, Tianjin, China Institutes for Systems Genetics West China Hospital Chengdu China National Laboratory for Infrared Physics; Shanghai Institute of Technical Physics; Chinese Academy of Sciences; Shanghai 200083; PR China Soybean Research Institute, Key Laboratory of Soybean Biology of Chinese Education Ministry, Northeast Agricultural University, Harbin 150030, China Department of Radiology, Qingdao Municipal Hospital, Qingdao, Shandong 266011, China Key Laboratory of Chinese Materia Medica, Ministry of Education of Heilongjiang University of Chinese Medicine, Harbin, P. R. China Department of Medical Oncology Beijing Key Laboratory of Clinical Study On Anticancer Molecular Targeted Drugs, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing 100021 P. R. China Department of Surgery, Yantai Shan Hospital, Yantai, Shandong 264003, P.R. China Department of Otolaryngology–Head and Neck Surgery, Beijing Tongren Hospital, Capital Medical University, Beijing, People’s Republic of China Department of Medical Oncology Cancer Institute (Hospital) Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China for the Million Veteran Program (MVP)Cooperative Studies Program (CSP) #572 Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing 100021, China. Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, Jinan 250012, China Qingdao University, School of Pharmacy, Qingdao Shandong, China Department of Ophthalmology Medical School of Southeast University, Nanjing 210009, People’s Republic of China Department of Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China. Department of Public Security Supervision Taizhou Municipal Hospital Taizhou China Institutes for Systems Genetics, West China Hospital, Sichuan University, Chengdu 610041, China School of Computer Science, Qufu Normal University , Rizhao 276826, China Department of Geriatric Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, China. Department of Ophthalmic Research, Cole Eye Institute and Lerner Research Institute, Cleveland Clinic, Cleveland, OH 1 Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China School of Pharmaceutical Sciences State Key Laboratory of Cellular Stress Biology Xiamen University Xiamen China BGI Genomics, BGI-Shenzhen, Shenzhen, Guangdong Province, People’s Republic of China Authors' Affiliations: 1Department of Environmental Health Sciences, Bloomberg School of Public Health, Johns Hopkins University, Baltimore Maryland; 2Qidong Liver Cancer Institute, Qidong, Jiangsu, PR China; 3Department of Epidemiology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore Maryland; 4School of Chemistry, University of St Andrews, St Andrews, Scotland; 5Department of Pharmacology and Molecular Sciences, School of Medicine, Johns Hopkins University, Baltimore Maryland; and 6Department of Pharmacology and Chemical Biology, University of Pittsburgh, Pittsburgh, Pennsylvania College of Veterinary Medicine, National Reference Laboratory of Veterinary Drug Residues, South China Agricultural University (SCAU), Guangzhou 510642, People's Republic of China Department of Radiation Oncology, Peking University Cancer Hospital and Institute, Beijing 100142, China Zhejiang University Institute of Animal Science, Chinese Academy of Agricultural Sciences, Beijing 100193, People’s Republic of China Departments of Pathology, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China. Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics Fujian Medical University Fuzhou China Orthopaedics Department The Second Hospital, Cheeloo College of Medicine, Shandong University Jinan China College of Horticulture, Northwest A & F University, Yangling 712100, Shaanxi, China. [email protected] Department of Pathogen Biology, Nanjing Medical University, 101 Longmian Rd., Nanjing, Jiangsu 211166, China ([email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]; [email protected]), Department of Pharmacology and Molecular Sciences, Johns Hopkins School of Medicine, 725 N. Wolfe Street, Baltimore, Maryland 21205, United States Kevin Harrington, Institute of Cancer Research and Royal Marsden Hospital, London; Hisham Mehanna, Institute of Head and Neck Studies and Education, University of Birmingham, Birmingham; Natalie Franklin and John Farrell, GlaxoSmithKline, Uxbridge, United Kingdom; Stephane Temam and Jean Bourhis, Institut Gustave- Roussy, Villejuif; Ida D'Onofrio, Hôpital Forcilles, Paris, France; Anil D'Cruz, Tata Memorial Hospital, Mumbai; Minish Jain, Ruby Hall Clinic–Cancer Centre, Pune, India; Georgy Manikhas, St... Key Laboratory of Tropical Diseases and Translational Medicine of the Ministry of Education & Hainan Provincial Key Laboratory of Tropical Medicine, Hainan Medical College, Haikou 571199, China Institute of Food Safety, Chinese Academy of Inspection & Quarantine, Beijing, China Department of Nephrology, East Campus, Renmin Hospital of Wuhan University, Wuhan, Hubei, China (mainland) School of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou, China Chongqing Key Laboratory of Medicinal Resources in the Three Gorges Reservoir Region,School of Biological and Chemical Engineering,Chongqing University of Education,Chongqing,China Department of Biological Sciences, Dankook University, Cheonan, Korea Department of Biostatistics Amgen Inc. CA USA Department of Gynecology and Obstetrics, Third Hospital of Hebei Medical University, Shijiazhuang 050051, China. E-mail: [email protected]. Department of Biochemical Engineering and Key Laboratory of Systems Bioengineering of Ministry of Education School of Chemical Engineering and Technology Tianjin University Tianjin China Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China Key Laboratory of Wheat and Maize Crops Science, College of Agronomy, Henan Agricultural University, Zhengzhou 450002, China *Laboratory of Biochemistry and Genetics, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20892; Institute of Hematology, Jinan University Medical College, Guangzhou 510632, China. Department of Anesthesiology, China Japan Union Hospital, Jilin University, Changchun, Jilin 130033, P.R. China The 7th Research Department, Shandong Institute of Non-Metallic Materials, Tianzhuang East Road No. 3, Jinan 250031, China; Institute of Laser & Optoelectronics, School of Precision Instruments and Opto-Electronics Engineering, Tianjin University, Tianjin 300072, China Department of Medical Oncology, Cancer Hospital/Institute, Chinese Academy of Medical Sciences & PUMC, Beijing 100021, P.R.China. Department of Pancreatic Surgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China; Sino‐German Laboratory of Personalized Medicine for Pancreatic Cancer Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Tianjin University Department of Biochemical Engineering, School of Chemical Engineering and Technology, , Tianjin 300072, China Hisun Biopharmaceutical Co. Ltd. Hangzhou China Department of Radiation Oncology, Peking University Cancer Hospital, Beijing, China Department of Nephrology, Hematology and Rheumatology, Yantai Affiliated Hospital, Binzhou Medical College, Yantai, People’s Republic of China Chinese Academy of Medical Sciences, Beijing 100021, China. [email protected] Dept. of Biochemical Engineering and Key Laboratory of Systems Bioengineering of the Ministry of Education School of Chemical Engineering and Technology, Tianjin University Tianjin 300072 China School of Civil Engineering; Chang'an University; Xi'an; China Department of Neurology and the F.M. Kirby Neurobiology Center Children's Hospital Boston Boston MA USA; Program in Neuroscience Harvard Medical School Boston MA USA Department of Obstetrics/Gynecology and Women's Health (Y.S., K.T., A.M.E., G.N.-P.), Albert Einstein College of Medicine, Bronx, New York 10461 Department of Clinical Pathogen Microbiology Qiqihar Medical University Qiqihar China Department of Head and Neck Surgery The University of Texas MD Anderson Cancer Center Houston TX; Department of Otorhinolaryngology and Head and Neck Surgery Yuhuangding Hospital of Qingdao University Yantai China Department of Neurology, Qingdao Municipal Hospital Qingdao University Qingdao China College of Grassland Science and Technology China Agricultural University Beijing China Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China; Beijing Institute of Heart Lung and Blood Vessel Disease, Beijing Key Laboratory of Precision Medicine of Coronary Atherosclerotic Disease, Clinical Center for Coronary Heart Disease, Capital Medical University, Beijing 100029, China Department of Medical Genetics, West China Hospital, Sichuan University, PR China. Department of Emergency and Oral Medicine, The School of Stomatology, China Medical University and Liaoning Institute of Dental Research and Liaoning Province Key Laboratory of Oral Diseases and Liaoning Province Translational Medicine Research Center of Oral Diseases, Shenyang, Liaoning 110002, P.R. China Department of Natural Products Chemistry, Key Lab of Chemical Biology of the Ministry of Education, Shandong University, Jinan 250012, People’s Republic of China Department of Oncology The First Affiliated Hospital of Zhengzhou University Zhengzhou China Hisun BioPharmaceutical Co., Ltd. Hangzhou China Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China College of Chemistry and Chemical Engineering; Yangzhou University; Yangzhou; P. R. China Department of Chemistry, School of Science, and High Pressure Adsorption Laboratory, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, P. R. China Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Department of Pathology Tianjin Medical University Cancer Institute and Hospital Tianjin 300060 China; Department of Pathology The University of Texas MD Anderson Cancer Center Houston TX 77030 USA Department of Pediatrics, Xinjiang Hospital of Beijing Children Children's Hospital of Xinjiang Uygur Autonomous Region Urumqi China National Institute on Drug Dependence Peking University Beijing China The Digital ART Lab of School of Software, Shanghai JiaoTong University, Shanghai 200240, China Department of Orthodontics, Ninth People's Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; Shanghai Key Laboratory of Stomatology. Shanghai 200011, China.E-mail:[email protected]. Department of Chemistry, Michigan State University, East Lansing, MI 48824 College of Pharmaceutical Sciences, Southwest University, Chongqing, P.R. China School and Hospital of Stomatology, Wenzhou Medical University, Wenzhou, Zhejiang, China Department of Echocardiography, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China Key Laboratory of Biorheological Science and Technology (Chongqing University), Ministry of Education, College of Bioengineering, Chongqing University, Chongqing, PR China Department of Emergency Medicine, The Clinical Medical School of Nanjing Medical University Affiliated Hospital of Lianyungang First People’s Hospital, No. 182 North Tongguan Road, Lianyungang 222002, China Health Care Department, Hebei Cangzhou Women And Children’s Health, Cangzhou, China Shenyang He Eye Specialist Hospital Shenyang China; He University Shenyang China Department of Biology University of Fribourg Fribourg 1700 Switzerland Department of Medical Oncology, Cancer Hospital Chinese Academy of Medical Sciences, Beijing, China Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;, Hospital of Obstetrics and Gynecology, Fudan University; Shanghai Key Laboratory of Female Reproductive Endocrine-related Disease; The Academy of Integrative Medicine of Fudan University Department of Otorhinolaryngology Head and Neck Surgery, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, P.R. China Department of Radiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, Jiangsu, China (mainland) Laboratory for Reproductive Immunology, Obstetrics and Gynecology Hospital of Fudan University, Shanghai, China. Department of Immunology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China.; Wuhan Institute for Neuroscience and Neuroengineering, South-Central University for Nationalities, Wuhan, China.; Department of Neurobiology, College of Life Sciences, South-Central University for Nationalities, Wuhan, China. Clinical Pharmacy Center, Department of Pharmacy, Chinese PLA General Hospital, Beijing, China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry Jilin University Changchun Jilin 130012 China Department of Chemistry, Key Laboratory of Nanobiosensing and Nanobioanalysis at Universities of Jilin Province Northeast Normal University Changchun China Department of Toxicology, School of Public Health, Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China Shandong University of Traditional Chinese Medicine Department of Pediatric Hematology, The Affiliated Hospital of Medical College, Qingdao University, No. 16 Jiangsu Road, Qingdao 266003, China Health Services and Outcomes Research Unit, National Healthcare Group, Singapore Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China Department of Neurology, Children’s Hospital of Xinjiang Uygur Autonomous Region, Xinjiang Hospital of Beijing Children’s Hospital, Urumqi, China Small Scale Systems Integration and Package (S3IP) Center, Binghamton University, Binghamton, New York 13902, United States Department of Orthopedics, Xuzhou City Hospital of Traditional Chinese Medicine, Xuzhou 221004, Jiangsu, China Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, China Reproductive Medicine Center, Northern Jiangsu People’s Hospital, Yangzhou University, Yangzhou, Jiangsu, China Department of Pediatric Hematology The Affiliated Hospital of Qingdao University Qingdao China Agricultural College, Shihezi University, Shihezi 832000, China for the Million Veteran Program Suicide Exemplar Workgroup, the International Suicide Genetics Consortium, the Veterans Affairs Mid-Atlantic Mental Illness Research, Education, and Clinical Center Workgroup, and the Veterans Affairs Million Veteran Program College of Chemistry and Chemical Engineering, Lab for Clean Energy & Green Catalysis, Anhui University, Hefei 230601, China; Department of Chemical and Materials Engineering, University of Kentucky, Lexington 40506, United States College of Life Sciences, Shanxi Normal University, Xi'an, Shanxi, China. Department of Otolaryngology Head and Neck Surgery, Xinhua Hospital, School of Medicine, Shanghai Jiaotong University; Ear Institute, School of Medicine, Shanghai Jiaotong University, Shanghai 200092, China. Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, People’s Republic of China Center of Reproductive Medicine, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics & Gynecology and Pediatrics, Fujian Medical University, Fuzhou, China Changsha Central Hospital, Changsha 410004, People’s Republic of China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry College of Chemistry Jilin University Changchun Jilin 130012 China Department of Biochemistry and Molecular Biology, The Pennsylvania State University, University Park, Pennsylvania, USA Cancer Hospital, Chinese Aacademy of Medical Sciences and Peking Union Medical College, Beijing 100021, China. Information Resources Department Hubei University of Medicine Shiyan Hubei China Shukui Qin, People's Liberation Army Cancer Centre, Bayi Hospital, Nanjing; Yuxian Bai, Third Affiliated Hospital, Harbin Medical University, Harbin; Jia Fan, Zhongshan Hospital, Fudan University; Yu Zhou, sanofi-aventis Asia, Shanghai; Yan Sun, Cancer Institute and Hospital, Chinese Academy of Medical Sciences, Beijing, China; Ho Yeong Lim and Won Ki Kang, Samsung Medical Centre; Won Ki Kang, Sungkyunkwan University School of Medicine; Jee Hyun Lee, sanofi-aventis Korea, Seoul, Korea; Sumitra... Amgen Inc, Thousand Oaks, California Department of Clinical Laboratory, Shanghai Children’s Hospital, Shanghai Jiaotong University, Shanghai, China Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Zhejiang Normal University, Jinhua 321004, China; Jilin Institute of Chemical Technology, 45 Chengde Street, Jilin 132000, China School of Basic Medical Sciences, Zhengzhou University, Zhengzhou, People's Republic of China. Department of Hospital Infection Management , Wuhu Second People’s Hospital , Wuhu , People’s Republic of China Key Laboratory of Flexible Electronics, Institute of Advanced Materials, and Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing Tech University, Nanjing 211816, China Institute of Microbiology, Chinese Academy of Sciences, Beijing 100080, China. [email protected] Department of Vascular Surgery, Shandong University, Jinan, China. Department of Radiology, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou, China. Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM) Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) Nanjing Tech University (NanjingTech) 30 South Puzhu Road Nanjing 211816 China Center for AIE Research, College of Materials Science and Engineering Shenzhen University Shenzhen China Engineering Technology Research Center of Traditional Chinese Veterinary Medicine of Gansu Province, Lanzhou Institute of Animal Husbandry and Pharmaceutical Sciences, Chinese Academy of Agricultural Sciences, Lanzhou 730050, China 1Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin, China.; 2Department of Pancreatic Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, China. Molecular Medicine and Cancer Research CenterChongqing Medical UniversityChongqingChina Department of Neurology and F. M. Kirby Neurobiology Center Boston Children's Hospital Boston MA; Neuromodulation Program Boston Children's Hospital Boston MA; Program in Neuroscience Harvard Medical School Boston MA Department of Obstetrics and Gynecology (G.N.-P., J.S., Y.S., A.M.E.), Albert Einstein College of Medicine, Bronx, New York 10461; Department of Dermatology, The First Hospital of China Medical University, Shenyang, China 17AbbVie Inc., North Chicago, Illinois. Department of Cardiology, Beijing Anzhen Hospital; Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Disease, The Key Laboratory of Remodeling-related Cardiovascular Disease, Ministry of Education, No. 2 Anzhen Road, Chaoyang District, Beijing, China Chinese Academy of Sciences Department of Anesthesiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China (mainland) Pharmaceutical College and Key Laboratory of Pharmacology for Natural Products of Yunnan Province, Kunming Medical University, Kunming, Yunnan 650500, P.R. China Ministry of Education Key Laboratory for Special Functional Materials, Henan University, Kaifeng 475004, China Key Laboratory of Luminescence and Real-Time Analytical Chemistry, Ministry of Education, College of Pharmaceutical Sciences, Southwest University, Chongqing, 400715, People’s Republic of China Department of Cell Biology, the Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, School of Basic Medical Sciences, Tianjin Medical University, Tianjin 300070, China Department of Biochemical Engineering and Key Laboratory of Systems Bioengineering of the Ministry of Education; School of Chemical Engineering and Technology; Tianjin University; Tianjin 300072, People's Republic of China Teaching Office, School of Rehabilitation Medicine, Henan University of Chinese Medicine, Zhengzhou 450058, China. Prescription Traching and Research Section, Institute of Literature in Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing 210046, China. Key Laboratory of Pollution Processes and Environmental Criteria (Ministry of Education), College of Environmental Science and Engineering, Nankai University, Tianjin 300071, China College of Horticulture, Northwest Sci-Tech University of Agriculture and Forestry, Yangling 712100, China. [email protected] Fujian Provincial Reproductive Medicine Center, Fujian Maternity and Child Health Hospital, College of Clinical Medicine for Obstetrics and Gynecology and Pediatrics, Fujian Medical University, Fuzhou 350001, China Department of Otorhinopharyngolaryngy and Head-neck Surgery, Affiliated Tongren Hospital, Capital Medical University, Beijing 100730, China Tianjin Key Laboratory of Neurotrauma Repair, Pingjin Hospital Brain Center Logistics University of PAPF Tianjin 300162 China School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China Max Planck Institute for Chemical Physics of Solids, D-01187 Dresden, Germany. Microbial Resource and Big Data Center, Institute of Microbiology, Chinese Academy of Sciences , Beijing 100101 , China; Chinese National Microbiology Data Center (NMDC) , Beijing 100101 , China School of Chemistry and Life Sciences, Suzhou University of Science and Technology, Suzhou City, Jiangsu Province 215009, China Key Laboratory of Tropical Diseases and Translational Medicine of the Ministry of Education & Hainan Provincial Key Laboratory of Tropical Medicine Hainan Medical College Haikou China Max Planck Institute for Chemical Physics of Solids, 01187 Dresden, Germany Department of Transplantation, Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China Key Laboratory of Catalysis and Materials Science of the State Ethnic Affairs Commission and Ministry of Education, College of Resources and Environmental Science, South-Central University for Nationalities, Wuhan 430074, China College of Pharmacy Shenyang Medical College Shenyang China The Reproductive Hospital of Guangxi Zhuang Autonomous Region, Nanning 530029, China *Department of Ophthalmology and Visual Sciences, Case Western Reserve University, Cleveland, OH 44106; COBRE in Stem Biology and Regenerative Medicine Center for Molecular Medicine, Maine Medical Center Research Institute, Maine Medical Center, Scarborough; College of Information and Communication Engineering University, Harbin 150001, Heilongjiang, China Obstetrics and Gynecology, Xishan People’s Hospital of Wuxi City, Wuxi 214000, Jiangsu, China College of Plant Protection, Northwest A&F University, Yangling, Shaanxi 712100, People’s Republic of China Heji Hospital Affiliated to Changzhi Medical College, Changzhi, China Department of Oral Biology, School of Bioscience and Technology Weifang Medical University Weifang Shandong People's Republic of China Texas Department of State Health Services, DNA Analysis Laboratory, Austin, TX, USA Department of Gynecology and Obstetrics, Third Affiliated Hospital, Third Department of Surgery, Hebei Medical University, Shijiazhuang 050051, China. The Academy of Integrative Medicine of Fudan University, Shanghai, China. Department of Pancreatic Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Sino-German Laboratory of Personalized Medicine for Pancreatic Cancer, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China School of Life Sciences and Hubei Key Laboratory of Genetic Regulation and Integrative Biology, Central China Normal University, Wuhan, Hubei 430079, People’s Republic of China Guangxi Key Laboratory of Agro-Environment and Agro-Products Safety, National Demonstration Center for Experimental Plant Science Education, Agricultural College, Guangxi University, Nanning, China Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, China Department of Otorhinolaryngology Head and Neck Surgery, Provincial Hospital Affiliated to Shandong University Jinan 250022, China ; Department of Otorhinolaryngology Head and Neck Surgery, Yuhuangding Hospital of Qingdao University Yantai 264000, China. National Institute on Drug Dependence; Peking University; China; Beijing Key Laboratory on Drug Dependence Research; China Department of Materials Science and Engineering, KAIST, Daejeon 34141, Republic of Korea; National Creative Research Initiative Center for Multi-Dimensional Directed Nanoscale Assembly, KAIST, Daejeon 34141, Republic of Korea Hubei University of Medicine, NO. 30 People South Road, Shiyan City, Hubei Province 442000, China Department of Pharmacology Department of Medicinal Chemistry, School of Pharmacy, Nanjing Medical University National Engineering Laboratory for Resource Development of Endangered Crude Drugs in Northwest China, Key Laboratory of the Ministry of Education for Medicinal Resources and Natural Pharmaceutical Chemistry, College of Life Sciences, Shaanxi Normal University, Xi’an, Shaanxi, China Department of Nutrition, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou 510080, China Department of Pediatrics, People’s Hospital of Xinjiang Uygur Autonomous Region, Urumqi, Xinjiang 830001, China School of Chemistry and Chemical Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China Departments of Pediatrics and Pathology, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642 Department of Otorhinolaryngology Head and Neck Surgery, Affiliated Yantai Yuhuangding Hospital of the Medical College of Qingdao University, Yantai 264000, China. Department of Biochemical Engineering and Key Laboratory of Systems Bioengineering of the Ministry of Education, School of Chemical Engineering and Technology, Tianjin University; Tianjin 300072; China Health Services Outcome Research, Singapore; the Department of Medical Oncology, Cancer Institute/Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing Key Laboratory of Clinical Study on Anticancer Molecular Targeted Drugs, Beijing, China High-Pressure Adsorption Laboratory, School of Chemical Engineering and Technology, and Department of Chemistry, School of Science, Tianjin University, Tianjin 300072, P. R. China Department of Chemistry, Michigan State University, East Lansing, Michigan 48824 Department of Chemistry and Biochemistry; Queens College of the City University of New York; Queens; USA; Ph.D. Program in Chemistry Department of Neurology, Affiliated Hospital of Logistics University of PAP, Key Laboratory of Nerve Trauma Repair in Tianjin, Tianjin 300162, China. Corresponding author: Zhang Sai, Email: [email protected]. Beijing Key Laboratory of Environmental and Viral Oncology, College of Life Science and Bioengineering,Beijing University of Technology Beijing 100124, China. School of Mechanical Engineering, Chengdu University, Chengdu 610106, P.R. China BGI Genomics, BGI-Shenzhen, Shenzhen, China; Department of Biology, University of Copenhagen, Copenhagen, Denmark; BGI-Wuhan, BGI-Shenzhen, Wuhan, China Key Laboratory of Synthetic and Self-Assembly Chemistry for Organic Functional Molecules Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 P. R. China College of Optical Science and Engineering, Zhejiang University, Hangzhou 310027, China Department of Geriatric Endocrinology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, P.R. China Department of Pathogen Biology, Nanjing Medical University, Nanjing, Jiangsu, PR China Chinese Brain Bank Center, South-Central University for Nationalities, Wuhan, China Authors' Affiliations: Departments of 1Pathology and 2Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China; and Departments of 3Pathology and 4Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, Texas; Authors' Affiliations: Departments of 1Pathology and 2Epidemiology and Biostatistics, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China; and Departments of 3Pathology and 4Cancer Biology, University of Texas MD Anderson Cancer Center, Houston, Texas Department of Nephrology The Third Affiliated Hospital of Chongqing Medical University (Gener Hospital) Chongqing China Department of Geriatrics The First Affiliated Hospital of Nanjing Medical University Nanjing China Department of Urology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, 500 Dongchuan Road, Shanghai, 200241, P.R. China Department of Otolaryngology-Head and Neck Surgery, Beijing Tong Ren Hospital, Capital Medical University, Beijing 100730, China. Beijing Tongren Hospital, Capital Medical University; Department of Otolaryngology - Head and Neck Surgery; No.1, Dong Jiao Min Xiang, Dongcheng District Beijing China 100730 Department of Biology, University of Copenhagen, Copenhagen DK‑2200, Denmark Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801 Department of Oncology, The Third People's Hospital of Linyi, Linyi, Shandong 276023, P.R. China Environmental Science and Engineering Institute Guangzhou University 510006 Guangzhou China From the Departments of Radiation Oncology (Y.Z., L.C., Y.-P.C., W.-H.H., W.-F.L., L.-L.T., Y.-P.M., G.-Q.Z., R.S., X.L., R.G., F.H., J.-W.L., X.-J.D., C.X., N.L., Y.-Q.L., F.-Y.X., Ying Sun, J.M.), Medical Oncology (Y.-H.L.), and Nasopharyngeal Carcinoma (H.-Y.M.) and the Clinical Trials Center (Y.G.), Sun Yat-sen University Cancer Center, the State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma... School of Mechanical Engineering, Chengdu University, Chengdu 610065, P. R. China Max Planck Institute for Chemical Physics of Solids Nöthnitzer Str. 40 Dresden 01187 Germany Health Services and Outcomes Research National Healthcare Group Singapore Singapore Department of Infectious Diseases, Henan Infectious Diseases Hospital, Zhengzhou, Henan 450000, China. From the Department of Ophthalmology and the Department of Neurology Qingdao Municipal Hospital Qingdao University Qingdao China Department of Otorhinolaryngology-Head and Neck Surgery, Yuhuangding Hospital of Yantai, Yantai, 264000, China. [email protected] Department of Dermatology The Third People’s Hospital of Hangzhou Hangzhou China 1Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, P.R. China.; 2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, P.R. China. Department of Pathology Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin, Tianjin's Clinical Research Center for Cancer Tianjin China Shanghai Changning Mental Health Center, Shanghai 200335, China The First Ward of Trauma Orthopedics Yantaishan Hospital Yantai Shandong China Beijing Advanced Innovation Centre for Biomedical Engineering, Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, School of Biological Science and Medical Engineering Beihang University Beijing China; School of Engineering Medicine, Beihang University No.37, Xueyuan Road, haidian district Beijing China Zhejiang Pharmaceutical College, Ningbo, Zhejiang, China |
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