http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_119f21d73beb9ccc54ab4cd573c077ae
Outgoing Links
Predicate | Object |
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family-name | Min Xu Xu |
name | Min Xu |
given-name | Min |
organization-name | Department of Cardiovascular Division of The Third Affiliated Hospital of Soochow University Chang Zhou City Jiangsu Province China; Department of Cardiovascular Division of The First Affiliated Hospital of Soochow University Su Zhou City Jiangsu Province China Department of Operating Theatre, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang, 325000, P.R. China Department of Otorhinolaryngology Head and Neck Surgery, Air Force Medical University, XiJing Hospital, Xian, Shanxi, China Department of Anesthesiology, Xiangyang No. 1 People's Hospital Hubei University of Medicine Xiangyang Hubei China Department of Gastroenterology, Shanghai First People's Hospital of Shanghai Jiaotong University School of Medicine, Shanghai 200011, P.R. China State Key Laboratory of Medical Genomics, and National Clinical Research Center for Metabolic Diseases Rui‐Jin Hospital affiliated with Shanghai Jiao‐Tong University School of Medicine Shanghai China Department of Medicine, University of Western Australia, Sir Charles Gairdner Hospital, Nedlands, WA 6009, Australia; Guangzhou University of Chinese Medicine, Guangzhou, P.R. China Department of Gastroenterology Affiliated Hospital of Jiangsu University Zhenjiang China Neuroimaging Laboratory, School of Biomedical Engineering, Shenzhen University Health Science Center, Shenzhen 518060, China.; Center for Language and Brain, Shenzhen Institute of Neuroscience, Shenzhen 518057, China. Molecular and Computational Biology, Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA Department of Pediatric Transplantation, Organ Transplantation Center, Tianjin First Central Hospital, Tianjin, China Quantitative Biosciences, Merck & Co., Inc., Rahway, New Jersey 07065, United States Department of Pathology, Hunan Provincial Brain Hospital, 410007, P. R. China. Department of Laboratories, Seattle Children's Hospital, Seattle, Washington; Department of Laboratory Medicine, University of Washington, Seattle, Washington The National Engineering Laboratory for Anti-Tumor Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing, China; Beijing Key Laboratory for Protein Therapeutics, School of Life Sciences, Tsinghua University, Beijing, China; Cancer Biology Laboratory, School of Life Sciences, Tsinghua University, Beijing, China College of Water Science, Beijing Normal University, Beijing 100875, China; Research Center of Water Pollution Control Technology, Chinese Research Academy of Environmental Sciences, Beijing 100012, China Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning, PR China Department of Otolaryngology‐Head and Neck Surgery The Second Affiliated Hospital of Xi’an Jiaotong University Xi'an China Departments of Surgery School of Medicine,Washington University,St. Louis,MO Department of Endocrinology and Metabolism, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan 250012, China Department of Immunology, College of Basic Medical Science ,Chongqing Medical University, Chongqing 400016, China. Key Laboratory of Bio-based Material Science and Technology of the Ministry of Education of China, College of Material Science and Engineering, Northeast Forestry University, Harbin, China. Department of Radiation Oncology, Shandong Cancer Hospital affiliated to Shandong University, Shandong Academy of Medical Sciences, Jinan, Shandong province, China, 250117 Department of General Surgery Tianjin Union Medical Center Tianjin China Department of Neurosurgery & Brain and Nerve Research Laboratory The First Affiliated Hospital of Soochow University Suzhou China Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China; and College of Pharmaceutical Science, Zhejiang University of Technology, 288 Liuhe Rd, Hangzhou 310014, P.R. China Department of Surgery, University of Pennsylvania School of Medicine , Philadelphia, Pennsylvania , USA Engineering Research Center of Nano-Geomaterials of Ministry of Education Faculty of Materials Science and Chemistry China University of Geosciences Wuhan 430074 China Department of Otorhinolaryngology-Head and Neck Surgery and Ear Institute, The Second Affiliated Hospital, Sweden Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200030, China; Tianjin Key Laboratory of Drug Delivery and High-Efficiency, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China Genentech, Inc., South San Francisco, California Institute of Medical Biology, Chinese Academy of Medical Science & Peking Union Medical College, Kunming 650118, China Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, China Translational Immunology, Genentech, Inc. South San Francisco California USA State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, China Yancheng First People's Hospital Yancheng 224006, Jiangsu Province, P. R. China. Departments of Medicinal & Biological Chemistry and Pharmacology, The University of Toledo, 2801 W. Bancroft St., Toledo, Ohio 43606 Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China Key Laboratory of Beijing on Regional Air Pollution Control, College of Environmental and Energy Engineering, Beijing University of Technology, Beijing 100124, China. Department of Ultrasound Medicine, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China; Key Laboratory of Pulsed Power Translational Medicine of Zhejiang Province, Hangzhou, Zhejiang 310003, China. Institute of Nephrology, Zhongda Hospital, Southeast University School of Medicine, Nanjing, China Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health Ruijin Hospital Shanghai Jiaotong University School of Medicine E‐Institute of Shanghai Universities Shanghai China; Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Department of Endocrine and Metabolic Diseases Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China Institute of Blood Transfusion Chinese Academy of Medical Sciences Chengdu China; Peking Union Medical College Chengdu China; Luoyang Blood Center Luoyang Henan China Key Laboratory of Luminescence and Optical Information; Ministry of Education; Institute of Optoelectronic Technology; Beijing Jiaotong University; Beijing 100044 Department of Cardiology, Beijing Anzhen Hospital, Beijing Institute of Heart Lung and Blood Vessel Diseases, Capital Medical University, Beijing 100029, China. Departments of Medicinal Chemistry, Molecular Systems, Structural Biology, Automated Biotechnology, and Alzheimer’s Research, Merck Research Laboratories, West Point, Pennsylvania 19486 Department of Laboratories, Seattle Children’s Hospital, Seattle, WA; Department of Laboratory Medicine, University of Washington, Seattle Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Pharmacy, School of Pharmaceutical Sciences, Sun Yat-sen University, University Town, Guangzhou 510006, People's Republic of China Department of Ultrasound Sun Yat‐Sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou 510060 China Department of Laboratories, Seattle, WA; Department of Laboratory Medicine, University of Washington, Seattle China Agricultural University National Maize Improvement Center, Department of Crop Genetics and Breeding, , Beijing, China Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China State Key Laboratory of Microbial Metabolism Shanghai-Islamabad-Belgrade Joint Innovation Center on Antibacterial Resistances Joint International Research Laboratory of Metabolic & Developmental Sciences School of Life Sciences and Biotechnology Shanghai Jiao Tong University Shanghai 200030 China Department of Pediatrics The Affiliated Hospital of Qingdao University Qingdao Shandong China Genentech, Inc., 1 DNA Way, South San Francisco, CA 94080, USA Research Center of Clinical Medicine Research Center of Gerontology and Longevity Key Laboratory of Immunology Research Center of Nursing Department of Rheumatology Affiliated Hospital of Nantong University Nantong University Nantong 226001 China Computational Biology Department, School of Computer Science, Carnegie Mellon University , Pittsburgh, PA 15213, USA Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang 212000, China Institute of Life Sciences Chongqing Medical University Chongqing People's Republic of China Department of Orthopedics, Second Xiangya Hospital, Central South University, Changsha 410011, China. [email protected] School of Biomedical Engineering Health Science Center, Shenzhen University Shenzhen 518060 China; Guangdong Provincial Key Laboratory of Biomedical Measurements and Ultrasound Imaging Shenzhen University Shenzhen 518060 China; Center for Neuroimaging Shenzhen Institute of Neuroscience Shenzhen 518057 China Department of Paediatric Transplantation Tianjin First Central Hospital Tianjin China; Tianjin Key Laboratory for Organ Transplantation Tianjin China Departments of *Gastrointestinal Medical OncologyThe University of Texas MD Anderson Cancer CenterHoustonTexasUSA; School of Medical Science and Laboratory MedicineJiangsu UniversityZhenjiangJiangsuPeople's Republic of China School of Environmental and Chemical Engineering, Shanghai University, 333 Nanchen Road, Shanghai 200444, PR China Department of Neurology, Xuanwu Hospital, Capital Medical University , Beijing, China Department of Gastroenterology, Jiangsu University Cancer Institute, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China (S.W., M.L., J.L., R.Z., J.N., M.X., T.W., Z.Z., S.W., H.L., Y.C., G.N., Y.B., W.W., Y.X.).; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the People’s Republic of China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China (S.W., M.L., J.L., R.Z., J.N., M.X., T.W., Z.Z., S.W., H.L., Y.C., G.N., Y.B., W.W., Y.X.). Radiology Department and Interventional Radiology Center, The Fifth Affiliated Hospital of Wenzhou Medical University, Affiliated Lishui Hospital of Zhejiang University, The Central Hospital of Zhejiang Lishui, Lishui, P.R. China Institute of Nephrology, Zhong Da Hospital, Southeast University School of Medicine, Nanjing, China State Key Laboratory of ASIC and System, School of Microelectronics, Fudan University, Shanghai 200433, China; Shanghai Integrated Circuit Manufacturing Innovation Center Co., Ltd., Shanghai 201202, China; Zhangjiang Fudan International Innovation Center, Shanghai 200433, China Department of Endocrinology, the First Affiliated Hospital, Anhui Medical University, Hefei, Anhui, 230022 PR China. Department of Otorhinolaryngology-HNS, Second Affiliated Hospital, Xi’an Jiaotong University School of Medicine, Xi’an, PR China; Department of Hematology, Longhua Hospital, Shanghai University of TCM. 6th floor, Building 1, No.725 Wanping South Rd., Shanghai, 200032, China. National Key Laboratory for Medical Genomes, Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, China National Research Center for Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China Department of Otolaryngology–Head and Neck Surgery The Second Hospital, Xi'an Jiao Tong University, Xi'an Department of Radiology, The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui, Zhejiang, P.R. China Department of Pathology and Laboratory Medicine; University of Cincinnati; Cincinnati Ohio 45237 Department of Laboratory Medicine, National Institutes of Health, Bethesda, Maryland 20892-1508 Reproductive Health and Infertility Clinic, Huai’an First People's Hospital, Nanjing Medical University, Huai’an State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, China Department of Ultrasonography, East Hospital, Tongji University, Shanghai, China. Guangzhou Eighth Municipal People's Hospital Guangzhou China State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, China; College of Resources and Environment, Huazhong Agricultural University, Wuhan 430070, China School of Educational Science Ludong University Yantai China; Collaborative Innovation Center for the Mental Health of Youth from the Era of Conversion of New and Old Kinetic Energy along the Yellow River Basin, Ludong University Yantai China Department of Otolaryngology (M.X.) The Second Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an China Department of Otolaryngology Head and Neck Surgery, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China Department of Environmental Engineering, College of Resources and Environmental Science, Nanjing Agricultural University, Nanjing 210095, P. R. China Quantitative Biosciences, Merck & Co., Inc., Kenilworth, New Jersey, USA Department of Radiology, Weihai Municipal Hospital, Cheeloo College of Medicine Shandong University Weihai China Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai 200062, China Institute of TCM-related Comorbid Depression, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing 210023, Jiangsu, China Clinical Trial Center, Huzhou Central Hospital, Huzhou, Zhejiang, People’s Republic of China Department of Cardiology, The Second Affiliated Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, P.R. China 1Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; 2National Clinical Research Center for Metabolic Diseases (Shanghai), Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, National Research Center for Translational Medicine, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China Fudan University State Key Laboratory of Crop Genetics and Germplasm Enhancement Cotton Hybrid R& D Engineering Center (the Ministry of Education) College of Agriculture Nanjing Agricultural University Nanjing China State Key Laboratory of Crop Genetics & Germplasm Enhancement and Utilization, Collaborative Innovation Center for Modern Crop Production co-sponsored by Jiangsu Province and Ministry of Education, Cotton Germplasm Enhancement and Application Engineering Research Center (Ministry of Education), Nanjing Agricultural University, Nanjing 210095, China From the Comprehensive Sickle Cell Center, Section of Hematology/Oncology (X.Z., S.S., V.R.G.), Section of Cardiology (A.A.D.), and Section of Pulmonary, Critical Care, and Sleep Medicine (J.G.N.G., R.F.M.), Department of Medicine, Institute of Human Genetics (W.Z., R.K.), Department of Pediatrics (W.Z.), and Institute for Personalized Respiratory Medicine (A.A.D., T.A., N.G.C., J.G.N.G., R.F.M.), University of Illinois at Chicago, Chicago, IL; Section of Pulmonary/Critical Care, Department of... Department of Pathology and Laboratory Medicine University of Cincinnati College of Medicine 2180 E. Galbraith Road Cincinnati OH 45215 USA Department of Laboratory Medicine and Pathology Seattle Children's Hospital Seattle Washington; Department of Laboratory Medicine University of Washington Seattle Washington Department of Infectious Diseases, Guangzhou Eight People's Hospital Guangzhou Medical University Guangzhou China Division of Pulmonary Medicine, The First Affiliated Hospital of Wenzhou Medical University, Key Laboratory of Heart and Lung, Wenzhou, Zhejiang 325000, P.R. China Department of Orthopedics, Central South University, Changsha, China. Department of Radiation Oncology Shandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences Jinan China College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, PR China Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology; National Engineering Research Center for Process Development of Active Pharmaceutical Ingredients Department of Biological Chemistry, Merck Research Laboratories, West Point, PA 19486, USA School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong Department of Cardiology Cardiovascular Institute of Chengdu Chengdu Third People's Hospital The Affiliated Hospital of Southwest Jiaotong Chengdu China Biology Science Institutes Chongqing Medical University Chongqing China Department of Nephrology, The 88th Hospital of People's Liberation Army, Taian, Shandong 271000, P.R. China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, China; Kunming College of Life Science, University of Chinese Academy of Sciences, China State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People’s Republic of China Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843-2128; and Department of Biological Sciences, State University of New York, 1400 Washington Avenue, Albany, NY 12222 Faculty of Basic Medical Sciences, Guilin Medical University, Guilin 541004, PRChina Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health Rui‐Jin Hospital, Shanghai Jiao‐Tong University School of Medicine, E‐Institute of Shanghai Universities Shanghai China; Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases Rui Jin Hospital Shanghai China Fairfield University, Department of Physics, Fairfield, Connecticut, United States 1National Engineering Laboratory for Anti-tumor Protein Therapeutics, Beijing, China.; 2Beijing Key Laboratory for Protein Therapeutics, Beijing, China.; 3Cancer Biology Laboratory, School of Life Sciences, Tsinghua University, Beijing, China. Department of Medical laboratory Zhumadian Central Hospital Zhumadian China College of Food Science and Engineering Ocean University of China Qingdao China Key Laboratory of Soil Environment and Pollution Remediation, Institute of Soil Science, Chinese Academy of Sciences, Nanjing 210008, China; University of Chinese Academy of Sciences, Beijing 100049, China Department of Radiology, Affiliated Lishui Hospital of Zhejiang University, The Fifth Affiliated Hospital of Wenzhou Medical University, The Central Hospital of Zhejiang, Zhejiang 323000, P. R. China Institute of Nuclear and New Energy Technology, Tsinghua University, Beijing, 100084, China College of Water Science, Beijing Normal University, Beijing 100875, China. Research Center of Water Pollution Control Technology, Chinese Research Academy of Environmental Sciences, Beijing 100012, China. School of Pharmacy, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, China Department of Ultrasonic Diagnosis, The Third People's Hospital of Chengdu, Chengdu, Sichuan, China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province Kunming Institute of Zoology Kunming Yunnan China; Kunming College of Life Science University of Chinese Academy of Sciences Kunming Yunnan China Institute of Stomatology Nanjing Medical University Nanjing China Department of Surgery, Shanghai Children’s Medical Center, Shanghai Jiao Tong University, School of Medicine, Shanghai, China Department of Obstetrics and Gynecology, Yancheng First City Hospital of Jiangsu Province, Yancheng, China. State Key Laboratory of ASIC and System, School of Microelectronics, Fudan University, Shanghai 200433, China; Shanghai Integrated Circuit Manufacturing Innovation Center Co., Ltd., Shanghai 200433, China David Braley Centre for Antibiotic Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario L8S 4K1, Canada; Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, West 7th Avenue No. 32, 300308 Tianjin, China; Haihe Laboratory of Synthetic Biology, West 15th Avenue No. 21, 300308 Tianjin, China School of Chemical Engineering and Technology, Tianjin University, Tianjin 300350, China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province KIZ/CUHK Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences Kunming China; Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences Shanghai China National Clinical Research Center for Oral Diseases, China (X.-N.S., L.-J.D., Yuan Liu, Yan Liu, J.-Y.S., Z.T., M.X., B.F., S.-Z.D.); Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, China (X.-N.S., L.-J.D., Yuan Liu, Yan Liu, J.-Y.S., Z.T., M.X., B.F., S.-Z.D.); Department of Orthodontics (M.X., B.F.), Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, China. Department of Horticulture, College of Agriculture and Biotechnology, Zhejiang University , Hangzhou 310058 , China Organ Transplant Center Tianjin First Central Hospital Tianjin China; Tianjin Key Laboratory for Organ Transplantation Tianjin China; Tianjin Key Clinical Discipline (Organ Transplantation) Tianjin China Shanghai Key Laboratory of Magnetic Resonance, School of Physics and Materials Science, East China Normal University, Shanghai, China Departments of Medicinal Chemistry, Structural Biology, Molecular Systems, and Alzheimer's Research, Merck Research Laboratories, P.O. Box 4, West Point, Pennsylvania 19486 Department of Geriatrics, Zhongnan Hospital of Wuhan University, Wuhan, Hubei Province Institute of Haematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China Department of Radiation Oncology Shandong Cancer Hospital and Institute Jinan China Department of Laboratories, Seattle Children’s Hospital, Seattle, Washington; Department of Laboratory Medicine, University of Washington, Seattle, Washington Department of Pathology, Xijing Hospital, Fourth Military Medical University, Changle West Road 169, Xi'an 710032, China; Department of Pathology and Pathophysiology, Fourth Military Medical University, Xi'an 710032, China Department of Clinical Laboratory, Changzhou No. 2 People’s Hospital, Nanjing Medical University, Changzhou 213003, China Department of Translational Immunology, Genentech, South San Francisco, California, USA Department of Translational Immunology, Genentech, South San Francisco, United States Imaging Center, Wuxi People's Hospital Nanjing Medical University Wuxi China Key Laboratory of Integrated Management of Crop Diseases and Pests, Ministry of Education, Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, China; Laboratory of Virology, Department of Plant Sciences, Wageningen University & Research, Droevendaalsesteeg 1, 6708PB Wageningen, The Netherlands Department of Radiation Oncology, Shandong Cancer Hospital and Institute (Shandong Cancer Hospital), Shandong First Medical University and Shandong Academy of Medical Sciences Department of Otolaryngology‐Head and Neck Surgery The Second Hospital, Xi'an Jiaotong University Xi'an China Department of Microbial and Biochemical Pharmacy, School of Pharmacy, China Medical University, Shenyang, Liaoning Province, China Clinical Laboratory and Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University, Affiliated Lishui Hospital of Zhejiang University, The Central Hospital of Zhejiang Lishui Lishui China Guangzhou Eighth Municipal People's Hospital, Guangzhou 510060, China. [email protected] Department of Cardiology, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China, and Graduate School of the Chinese Academy of Sciences, Beijing 100039, People's Republic of China Department of Oral and Maxillofacial Implantology, National Clinical Research Center of Stomatology, Shanghai Perio‐Implant Innovation Center, School of Medicine Ninth People’ Hospital, Shanghai Jiao Tong University Shanghai China Center for Plant Water-Use and Nutrition Regulation and College of Life Sciences, Joint International Research Laboratory of Water and Nutrient in Crop, Fujian Agriculture and Forestry University, Jinshan, Fuzhou 350002, China Key Laboratory of Imaging Diagnosis and Minimally Invasive Interventional Research of Zhejiang Province, Lishui Hospital, School of Medicine, Zhejiaing University, Lishui 323000, Zhejiang, China Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China Department of Pharmacy The Third People's Hospital of Chengdu The Affiliated Hospital of Southwest Jiaotong University The Second Chengdu Hospital Affiliated to Chongqing Medical University Chengdu China Key Laboratory for Biomechanics and Mechanobiology of the Ministry of Education, School of Biological Science and Medical Engineering, Beihang University, Beijing 100191, China Department of Gastroenterology Affiliated Hospital of Jiangsu University, Jiangsu University Zhenjiang China Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor Computational Biology and Computer Science Departments, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA Department of Critical Care Medicine, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of the Ministry of Health Department of Endocrine and Metabolic Diseases National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai China Department of Plant Pathology, and MOA Key Laboratory of Plant Pathology China Agricultural University Beijing China Henan Provincial Tobacco Company, Zhengzhou 4510018, China Department of Otolaryngology Head and Neck Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi’an, China Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology, Hangzhou 310014, China Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China (Y.W., C.Y., L.K., J.Z., M.X., Y.X., M.L., Z.Z., J.L., Y.C., W.W., G.N., Y.B., T.W.).; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, China (Y.W., C.Y., L.K., J.Z., M.X., Y.X., M.L., Z.Z., J.L., Y.C., W.W., G.N., Y.B., T.W.). Center for Pharmaceutical Sciences and Engineering, Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China State Key Laboratory of Phytochemistry and Plant Resources in West China; Kunming Institute of Botany; Chinese Academy of Sciences; Kunming 650201, People's Republic of China State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, China; Department of Ultrasound, Sun Yat-Sen University Cancer Center, Guangzhou, China; Department of Ultrasound, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health The National Clinical Research Center for Metabolic Diseases of Ministry of Health Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine E‐Institute of Shanghai Universities Shanghai China; Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Department of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai China Department of Oral Anatomy and Physiology, School and Hospital of Stomatology, Zunyi Medical University, Zunyi, China. Program in Molecular and Computational Biology, University of Southern California 1 1 Los Angeles, USA Department of Translational Immunology, Genentech Inc., South San Francisco, CA 94080; Department of Neurobiology, Nanjing Medical University, Nanjing, China; Key Laboratory of Human Functional Genomics of Jiangsu, Nanjing Medical University, Nanjing, China Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, 197 Rui-Jin 2nd Road, Shanghai 200025, China; Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, E-Institute of Shanghai Universities, Shanghai 200025, China Canon Medical Systems, Beijing, China. Department of Endocrinology, Changzhou No. 2 People’s Hospital, Nanjing Medical University, Changzhou 213003, China Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, East China Normal University, Shanghai, 200062, P. R. China Department of Pathology, Xijing Hospital; Department of Pathology and Pathophysiology; the 88th Hospital of PLA, Taian, People's Republic of China Department of Nursing Tongren Hospital Hongqiao International Institute of Medicine Shanghai Jiao Tong University School of Medicine Shanghai China Center for Fusion Science of Southwestern Institute of Physics 3 , P. O. Box 432, Chengdu 610041, China Center for Fusion Science of Southwestern Institute of Physics 3 , P.O. Box 432, Chengdu 610041, China School of Life Sciences, Central China Normal University Wuhan China Department of Oncology, RenMin Hospital of WuHan University, WuHan, Hubei, P.R. China Key Laboratory for Endocrine and Metabolic Diseases (M.L., Y.X., M.X., L.M., T.W., Y.L., Y.C., J.Lu., J.Li., Y.B., G.N.), Shanghai 200025 China; Ministry of Health, and Shanghai Clinical Center for Endocrine and Metabolic Diseases (M.L., Y.X., M.X., T.W., M.D., Y.C., J.Lu., J.Li., Y.B., G.N.), Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, E-Institute of Shanghai Universities, Shanghai 200025 China State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China Cardiovascular Center, Beijing Friendship Hospital, Capital Medical University, Beijing, China Department of Otolaryngology and Head and Neck Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, China 0000 0004 1936 8227 grid.25073.33 M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences DeGroote School of Medicine, McMaster University 1280 Main Street West L8S 4K1 Hamilton ON Canada Guangzhou No.8 People's Hospital Guangzhou Department of Cardiology, Luhe Hospital, Capital Medical University, China Department of Pharmacy The Third People's Hospital of Chengdu & College of Medicine, Southwest Jiaotong University Chengdu China Department of Cardiology Beijing Luhe Hospital Capital Medical University Beijing China State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Nanjing University, Nanjing 210023, P. R. China First Central Clinical College of Tianjin Medical University, Tianjin 300192, P.R. China College of Horticulture and Forestry, Xinjiang Agricultural University, Urumqi, China; Laboratory of Germplasm Resources and Efficient Production of Horticultural Crops in Xinjiang, Urumqi, China Guangzhou Eighth People's Hospital Guangzhou China Department of Plant and Microbial Biology, University of California, Berkeley CA 94720;; Department of Biology, Northwest University, 710069 Xi’an, China Carnegie Mellon University Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts 10Department of Pathology, Yale University, New Haven, CT Key Laboratory of Materials Physics, Centre for Environmental and Energy Nanomaterials, Anhui Key Laboratory of Nanomaterials and Nanotechnology, Institute of Solid State Physics, HFIPS Chinese Academy of Sciences Hefei 230031 China; University of Science and Technology of China Hefei 230026 China Department of Physiology and Pathophysiology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an, Shaanxi, China Institute of Blood Transfusion Chinese Academy of Medical Sciences Chengdu Sichuan China School of Energy Materials and Chemical Engineering Hefei University Hefei 230000 China 4Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA; 5Division of Reproductive Endocrinology and Infertility, University of Michigan, Ann Arbor, Michigan, USA Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Drug Discovery & Innovation Center, College of Chemistry and Life Sciences, Zhejiang Normal University, China State Key Laboratory of ASIC and System, Department of Microelectronics, Fudan University, Shanghai 200433, People's Republic of China Department of Otolaryngology, Shaanxi Provincial People’s Hospital, Xi’an, China Changsha Municipal Hospital of Chinese Medicine, Changsha 410100, China. Department of Occupational and Environmental Health, School of Public Health, Guangxi Medical University, No. 22, Shuangyong Road, Nanning 530021, China Department of Translational Immunology, Genentech, South San Francisco, CA, USA. Department of Laboratories, Seattle Children's Hospital, Seattle, WA; Department of Laboratory Medicine, University of Washington, Seattle, WA State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, and Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Computational Biology Department Carnegie Mellon University Pittsburgh, PA, United States. Key Laboratory of Materials Physics Centre for Environmental and Energy Nanomaterials Anhui Key Laboratory of Nanomaterials and Nanotechnology CAS Center for Excellence in Nanoscience Institute of Solid State Physics HFIPS Chinese Academy of Sciences Hefei 230031 China; University of Science and Technology of China Hefei 230026 China Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio Shanghai National Clinical Research Center for Metabolic Diseases Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai Institute of Endocrine and Metabolic Diseases Shanghai China South China Institute of Environmental Sciences, Ministry of Ecology and Environment, Guangzhou 510535, China. Department of Pharmacology and Laboratory of Cerebrovascular Pharmacology College of Pharmaceutical Science Soochow University Suzhou 215123 China National Clinical Research Center for Metabolic Diseases Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China Eighth People’s Hospital, Guangzhou, China Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, China; Shandong Academy of Medical Sciences, Jinan, China Carnegie Mellon University,Computational Biology Department,United States Vascular Surgery Division, Department of Surgery, Stony Brook University, Stony Brook, NY, USA Department of Pharmacy, School of Animal Medicine, Sichuan Agricultural University, Chengdu, Sichuan 611130, P.R. China Department of Pediatric Surgery, Burns and Plastic Surgery, and Hemorrhoids Fistula Surgery, Yidu Central Hospital of Weifang, Shandong 262500, P.R. China Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu 212000, P.R. China National Key Laboratory of Plant Molecular Genetics, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Shanghai, China Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health (T.W., M.L., M.X., Y.X., Y.H., J.L., Y.C., W.W., X.L., Y.L., Y.B., S.L., G.N.), Shanghai 200025, China; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism (T.W., M.L., M.X., Y.X., Y.H., J.L., Y.C., W.W., X.L., Y.L., Y.B., G.N.), Shanghai 200025, China Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China; Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao‐Tong University School of Medicine Shanghai China School of Physical Science and Technology, Southwest Jiaotong University, Chengdu 610031, China School of Public Health, Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, China Department of Cardiovascular Division of The Third Affiliated Hospital of Soochow University Chang Zhou City China; Department of Cardiovascular Division of The First Affiliated Hospital of Soochow University Su Zhou City China State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 354 Fenglin Road, Shanghai 200032, P. R. China Research Center of Clinical Medicine Affiliated Hospital of Nantong University Nantong China State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health National Clinical Research Center for Metabolic Diseases Collaborative Innovation Center of Systems Biomedicine Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Jiao Tong University School of Medicine Shanghai China; Shanghai Institute of Endocrine and Metabolic Diseases Department of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Computational Biology Department, Carnegie Mellon University, Pittsburgh, PA, USA Department of Otorhinolaryngology - Head and Neck Surgery, Second Affiliated Hospital, Xi’an Jiaotong University School of Medicine, Xi’an, People’s Republic of China; College of Medicine, Yangzhou University, Yangzhou, Jiangsu 225001, China; The State Administration of Traditional Chinese Medicine Key Laboratory of Toxic Pathogens-Based Therapeutic Approaches of Gastric Cancer, Yangzhou University, Yangzhou, Jiangsu 225009, China Affiliated Hospital of Nantong University, Nantong 226001, PR China, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, PR China, Changhai Hospital, Secondary Military Medical University, Shanghai 200433, PR China, Shanghai 9th People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, PR China, and Xiamen University, Xiamen 361005, PR China Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission, National Clinical Research Center for Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Institute of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China National Clinical Research Center for Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China a State Key Laboratory of Phytochemistry and Plant Resources in West China , Kunming Institute of Botany, Chinese Academy of Sciences , Kunming, 650204, China Department of Otolaryngology Head and Neck Surgery, The Affiliated Changsha Central Hospital, Hengyang Medical School of University of South China, Changsha, Hunan 410000, China Department of Oncology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, P.R. China Assisted Reproduction Laboratory, Center for Reproductive Medicine University of Michigan Ann Arbor MI USA Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, PRC Department of Chemistry, School of Pharmacy, The Air Force Medical University, Xi’an 710032, China From the Department of Noninvasive Cardiac Function, Heart Center (F.M., M.C., M.X.), and Department of Radiology (N.X.), East Hospital, Tongji University School of Medicine, Shanghai, China; and Prince of Wales Hospital, Chinese University of Hong Kong, Hong Kong (J.P.S., A.P.L., X.S.Y., C.Y.). Department of Hematology, Zhangjiagang Hospital of Soochow University, Zhangjiagang, China; Liver Center Gastrointestinal Division Massachusetts General Hospital Harvard Medical School Boston Massachusetts USA Beijing National Laboratory for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China College of Biosystems Engineering and Food Science; Zhejiang University; Hangzhou; PR China; Key Laboratory of On Site Processing Equipment for Agricultural Products State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Chinese Clinical Research Center for Metabolic Diseases Rui‐Jin Hospital, Shanghai Jiao‐Tong University School of Medicine Shanghai China; Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases Rui‐Jin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China Department of Radiology and Medical Imaging, Huai’an Hospital Affiliated of Xuzhou Medical University, Huaian, China. Department of Infectious Diseases Center, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, China Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research the Fifth Affiliated Hospital of Wenzhou Medical University /Affiliated Lishui Hospital of Zhejiang University/ The Central Hospital of Zhejiang Lishui Lishui China; Department of Radiology the Fifth Affiliated Hospital of Wenzhou Medical University /Affiliated Lishui Hospital of Zhejiang University/ The Central Hospital of Zhejiang Lishui Lishui China School of Physics and Electronic Science & Shanghai Key Laboratory of Magnetic Resonance East China Normal University Shanghai 200062 P. R. China State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, China; Hubei Key Laboratory of Soil Environment and Pollution Remediation, Huazhong Agricultural University, Wuhan, China Center for Disease Control and Prevention, Chengdu Military Region, Chengdu 610021, China Department of Orthopedics, Second Xiangya Hospital, Central South University, Changsha, China. Department of Hematology and Oncology Wuhan Children's Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Hepatobiliary Surgery, Yueyang Central Hospital, Yueyang, China Laboratory of Clean Energy Chemistry and Materials, State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou 730000, China; School of Physical Science and Technology, Lanzhou University, Lanzhou 730000, China Department of Anatomy, College of basic medicine Jinzhou Medical University Jinzhou China Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Biochemistry and Biophysics, Texas A&M University, 2128 TAMU, College Station, Texas 77843-2128 School of Chemical Engineering and Technology Tianjin University 135 Yaguan Road Tianjin 300350 China Department of Agronomy , Iowa State University, Ames, Iowa 50011 and Translational Immunology Department, Genentech Inc., South San Francisco, California, USA Department of Nephrology, Wujin Hospital Affiliated with Jiangsu University, Changzhou, Jiangsu, China; Department of Nephrology, The Wujin Clinical College of Xuzhou Medical University Changzhou, Jiangsu, China. Department of Urology Jinhua Municipal Central Hospital Jinhua China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases National Clinical Research Centre for Infectious Diseases Collaborative Innovation Centre for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital,Zhejiang University School of Medicine Hangzhou 310003 China Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China (Q.Y., R.Z., S.W., M.L., T.W., Z.Z., M.X., J.L., Y.C., G.N., W.W., Y.B., Y.X.).; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China (Q.Y., R.Z., S.W., M.L., T.W., Z.Z., M.X., J.L., Y.C., G.N., W.W., Y.B., Y.X.). Institute of Remote Sensing and Digital Earth, Chinese Academy of Sciences, Beijing, China Affiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, Shandong, People’s Republic of China. Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA. From the Department of Nutrition (Y.Z., M.X., Y.L., A.H., E.B.R., F.B.H., L.Q.) and Department of Epidemiology (E.B.R., F.B.H., J.E.M.), Harvard T.H. Chan School of Public Health, Boston, MA; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China (M.X.); Department of Epidemiology, German Institute of Human... Department of Nephrology Xuhui District Central Hospital of Shanghai Shanghai China Central Laboratory, Department of Liver Diseases, ShuGuang Hospital Affiliated to Shanghai University of Chinese Traditional Medicine, Shanghai, China Center for Sickle Cell Disease, Department of Medicine, Howard University, Washington, DC, USA College of Pharmacy, School of Modern Chinese Medicine Industry, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China Department of Pharmaceutical Science, Second Military Medical University School of Pharmacy, Shanghai 200433, China Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Shanghai Institute of Endocrine and Metabolic Diseases, China National Research Center for Metabolic Diseases, National Key Laboratory for Medical Genomes, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine (SJTUSM), Shanghai, China Departments of Medicinal Chemistry, Biological Chemistry, Molecular Systems, and Structural Biology, Merck Research Laboratories, P.O. Box 4, West Point, Pennsylvania 19486 Breast Surgery Affiliated Cancer Hospital, Institute of Guangzhou Medical University, Guangzhou 510000, China Immunobiology and Cancer Program, Oklahoma Medical Research Foundation Eskitis Institute for Drug Discovery, Griffith University, Brisbane, QLD 4111, Australia Department of Radiology the Fifth Affiliated Hospital of Wenzhou Medical University Lishui Hospital of Zhejiang University Lishui Central Hospital Lishui China Department of Pharmaceutical Sciences and Experimental Therapeutics, College of Pharmacy, University of Iowa, Iowa City, Iowa, USA State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic and Developmental Sciences, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, People's Republic of China Molecular and Computational Biology, Department of Biological Sciences, and Guangdong Provincial Key Laboratory of Biotechnology for Plant Development School of Life Sciences South China Normal University Guangzhou 510631 China State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, P. R. China 650201 Department of Gastroenterology, Affiliated Hospital of Jiangsu University Jiangsu University Zhenjiang China Department of Echocardiography, The Third Affiliated Hospital of Soochow University, Chang Zhou City, Jiangsu Province, China. Department of Environmental and Occupational Health, School of Public Health, Guangxi Medical University, Nanning 530021, Guangxi, China Department of Nephrology, Wujin Hospital Affiliated with Jiangsu University, China; Department of Nephrology, The Wujin Clinical College of Xuzhou Medical University, China. Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research School of Medicine Lishui Hospital of Zhejiang University Lishui China; Department of Radiology the Fifth Affiliated Hospital of Wenzhou Medical University Affiliated Lishui Hospital of Zhejiang University The Central Hospital of Zhejiang Lishui Lishui China *Department of Immunology, Genentech, South San Francisco, CA 94080; Institute of Nephrology, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, China Chinese Education Ministry’s Key Laboratory of Western Resources and Modern Biotechnology, Key Laboratory of Biotechnology Shaanxi Province, Shaanxi Key Laboratory for Carbon Neutral Technology, Shaanxi Academy of Basic Sciences, College of Life Sciences, Northwest University, Xi’an 710069, China Liver Center,Gastrointestinal Division,Massachusetts General Hospital,Boston,Massachusetts,USA Department of Laboratories, Seattle Children's Hospital, Seattle, WA, USA; Department of Laboratory Medicine, University of Washington, Seattle, WA, USA Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of Chinese Health Ministry, Ruijin Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200025, China Department of Physics, Shanghai Key Laboratory of Magnetic Resonance, East China Normal University, Shanghai 200062, People’s Republic of China Genomics and Genetic Engineering Laboratory of Ornamental Plants College of Agriculture and Biotechnology, Zhejiang University Hangzhou China Division of Neurobiology, Department of Molecular and Cell Biology, Helen Wills Neuroscience Institute, Howard Hughes Medical Institute, University of California, Berkeley, CA 94720, USA. Departments of Medicinal Chemistry, Alzheimer's Research, and Drug Metabolism, Merck Research Laboratories, Post Office Box 4, West Point, Pennsylvania 19486 Department of Agronomy and Interdepartmental Genetics Graduate Program, Iowa State University, Ames, IA 50011, USA. Longhua Hospital, Shanghai University of Traditional Chinese Medicine, Shanghai, China. Department of Ultrasound Medicine, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 31000, P. R. China Institute of Organic Chemistry; School of Chemistry and Chemical Engineering; Shandong University; Jinan 250100; P.R. China Xuanwu Hospital of Capital Medical University. State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health the National Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai China Department of Radiation Oncology, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan Howard Hughes Medical Institute, Departments of Medicine and Microbiology/Immunology, University of California San Francisco, San Francisco, California Department of Ophthalmology, Northern Jiangsu People's Hospital, Yangzhou, China. Department of Ophthalmology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Liaoning Key Laboratory of Diabetic Cognitive and Perceptive Dysfunction, Jinzhou Medical University, Jinzhou, 121000, China Department of Clinical Hematology, Key Laboratory of Laboratory Medical Diagnostics Designated by The Ministry of Education, Chongqing Medical University, Chongqing, People's Republic of China Key Laboratory of Medicinal Resources and Natural Pharmaceutical Chemistry, Ministry of Education,China. [email protected] Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming 650223, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming 650204, China Hong Kong Baptist University Kowloon Tong Hong Kong College of Electrical Engineering; Southwest Minzu University; Chengdu 610041; China 3Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan, China. School of Electrical and Information Engineering of Jiangsu University Zhenjiang China Dongfeug Peugeot Citroen Automobile Company LTD, Wuhan 430056, China. Department of Biochemistry and Biophysics, Texas A&M University, College Station, TX 77843–2128, USA. Department of Pharmacology, School of Medicine, Southeast University, Nanjing, China *Harrison Department of Surgical Research and Department of Surgery, University of Pennsylvania, Philadelphia, PA 19104; and From the Department of Pathophysiology, Shanghai Institute of Hematology, Rui-Jin Hospital, Shanghai Second Medical University, Shanghai, China; the Health Science Center, Shanghai Institutes for Biological Sciences and Graduate School, Chinese Academy of Sciences, Shanghai, China; the Department of Hematology, Zhong-Shan Hospital, Fu-Dan University, Shanghai, China; and the Department of Medicine/Endocrinology, Weill Medical College of Cornell University, New York, NY. Shanghai National Clinical Research Center for Metabolic Diseases Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases Shanghai China Department of Pathology and Laboratory Medicine, University of Cincinnati, Cincinnati, Ohio; and Department of Pediatrics, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China Women’s Hospital School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People’s Republic of China Institute of Developmental Psychology, School of Psychology, Beijing Normal University, Beijing, China; Beijing Key Laboratory of Applied Experimental Psychology, School of Psychology, Beijing Normal University, Beijing, China Ningbo Cigarette Factory, China Tobacco Zhejiang Industry Co., Ltd., Ningbo 315040, China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou City, China School of Food and Bio‐Engineering Xihua University Chengdu China Department of Advanced Stroke Center, The Xinhua Hospital of Ili Kazak Autonomous Prefecture, Ili, Xinjiang, People’s Republic of China Southwestern Institute of Physics 1 , P.O. Box 432, Chengdu 610041, China Tianjin Key Laboratory of Drug Delivery & High-Efficiency; School of Pharmaceutical Science and Technology; Tianjin University; Tianjin; PR China Department of Pediatric Surgery Shanghai Children’s Medical Center Affiliated to Shanghai Jiaotong University School of Medicine Shanghai China Department of Otolaryngology – Head & Neck Surgery, Second Affiliated Hospital of Xi’an Jiaotong University School of Medicine, Xi’an, China Department of Gastroenterology Affiliated Hospital of Jiangsu University Jiangsu University Zhenjiang China Key Laboratory for Endocrine and Metabolic Diseases, Ministry of Health, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, E-Institute of Shanghai Universities, Shanghai 200025, China; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200025, China; . Department of Cell and Developmental Biology, University College London, London, UK Department of Neurology the First Affiliated Hospital of Soochow University Suzhou Jiangsu China Department of Plant and Microbial Biology, University of California, Berkeley, CA 94720 State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Shanghai Jiao‐Tong University School of Medicine, Shanghai, China; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Rui‐Jin Hospital, Shanghai Jiao‐Tong University School of Medicine, Shanghai, China Department of Pathology, Seattle Children’s Hospital, University of Washington, Seattle, WA; Department of Hematology and Oncology, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science and Technology , Wuhan, China Department of Pathology and Laboratory Medicine, Metabolic Diseases Institute, University of Cincinnati, Cincinnati, Ohio; Institute of Engineering Thermophysics; Chinese Academy of Sciences; Beijing 100190; China State Key Laboratory of Brain and Cognitive Sciences, Department of Linguistics, and Shenzhen Institute of Research and Innovation, University of Hong Kong, Hong Kong Department of Pharmacy, The Third People's Hospital of Chengdu, College of Medicine, Southwest Jiaotong University, Chengdu, China Genentech, Inc., Translational Immunology, South San Francisco, California, USA Institute of Haematology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Department of Gastroenterology, Changhai Hospital, The Second Military Medical University, Shanghai 200433, P.R. China. State Key Laboratory of Microbial Metabolism and School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai, China State Key Laboratory of Medical Genomics National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China; Shanghai Institute of Endocrine and Metabolic Diseases, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China PegBio Co., Ltd. Suzhou Jiangsu China Department of Neurology, Xuanwu Hospital Capital Medical University Beijing China The State Key Laboratory of Freshwater Ecology and Biotechnology Institute of Hydrobiology Chinese Academy of Sciences Wuhan Hubei China Center for Pharmaceutical Sciences Faculty of Life Science and Technology Kunming University of Science and Technology Kunming China Institute of Engineering Thermophysics, Chinese Academy of Sciences, Beijing 100190, China; Nanjing Institute of Future Energy System, Nanjing 211135, China Department of Laboratory Medicine, Warren Grant Magnuson Clinical Center, National Institutes of Health, Bethesda, Maryland 20892-1508 School of Pharmacy Shanghai University of Traditional Chinese Medicine Shanghai China USDA ARS CICGR, Department of Agronomy, Iowa State University, Ames, IA 50011-1010, USA.; Crop Research Institute, Anhui Academy of Agricultural Sciences, Hefei, Anhui, People’s Republic of China.; Department of Agronomy, Iowa State University, Ames, IA 50011-1010, USA. Departments of Surgery,Washington University School of Medicine,St. Louis,MO Egret Pharma (Shanghai) Co., Ltd, 4F, 1118 Halei Road, Zhangjiang Hi-Tech Park, Pudong New Area, Shanghai 201203, P. R. China Institute of Blood Transfusion, Peking Union Medical College, Chinese Academy of Medical Sciences Chengdu China School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 100081, People’s Republic of China State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People’s Republic of China Department of Cardiac Ultrasound, The Third People's Hospital of Chengdu, Affiliated Hospital of Southwest Jiaotong University Department of Radiology, Maanshan People’s Hospital, Maanshan, Anhui, China Global Health Drug Discovery Institute, Haidian, Beijing 100192, China Cultivation Base of State Key Laboratory of Humid Subtropical Mountain Ecology, Fujian Normal University, Fuzhou 350007, China. School of Geographical Science, Fujian Normal University, Fuzhou 350007, China. Tianjin Normal University Jiangsu Key Laboratory of Oral Diseases Nanjing Medical University Nanjing China State Key Laboratory for Structural Chemistry of Unstable and Stable Species, Institute of Chemistry, Chinese Academy of Sciences, CAS Research/Education Center for Excellence in Molecular Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China School of Chemistry and Chemical Engineering, State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, P. R. China Department of Cardiovascular Division The Third Affiliated Hospital of Soochow University Chang Zhou China State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, Peopleʼs Republic of China Department of Otolaryngology-Head and Neck Surgery, Xijing Hospital, Air Force Millitary Medical University, Xi’an, Shaanxi Province, China Department of Radiology, the Affiliated Huai'an Hospital of Xuzhou Medical University. Institute of Automation, Chinese Academy of Sciences, Beijing 100190, China Department of Clinical Laboratory The First Affiliated Hospital of Zhengzhou University Zhengzhou China Dalian marine diesel CO., Ltd, Dalian 116083, China School of Chemistry University of St Andrews St Andrews KY16 9ST UK Key Laboratory of Flexible Electronics (KLOFE) and Institute of Advanced Materials (IAM) Nanjing Tech University (Nanjing Tech) 30 South Puzhu Road Nanjing 211816 China State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200030, China Department of Translational Immunology Genentech, Inc. South San Francisco CA USA Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, E-Institute of Shanghai Universities, Shanghai, China, and the Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Rui-jin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Tianjin Key Laboratory of Drug Delivery & High‐Efficiency School of Pharmaceutical Science and Technology Tianjin University Tianjin 300072 P. R. China Department of Otorhinolaryngology, Head and Neck Surgery, Second Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an 710004, China. Email: [email protected]. Department of Pharmacology, Merck Research Laboratories, West Point, Pennsylvania, USA National Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China; Northwest Science Technology University of Agriculture and Forestry, Yangling, China; Northeast Agricultural University, Harbin, China School of Chinese Materia Medica, Nanjing University of Chinese Medicine, 138 Xianlin Road, Nanjing, 210023, China Department of Gastroenterology, Shanghai General Hospital of Nanjing Medical University, Shanghai 200080, P.R. China Department of Physics, East China Normal University, Shanghai, 200062, China Jiangsu Key Laboratory for Molecular and Medical Biotechnology College of Life Sciences Nanjing Normal University Nanjing Jiangsu PR China Institute for Stem Cell and Neural Regeneration, School of Pharmacy, Nanjing Medical University, Nanjing, China School of Microelectronics, Fudan University, Shanghai200433, China Eskitis Institute, Griffith University, Brisbane, QLD 4111, Australia School of Pharmacy Shanghai University of Traditional Chinese Medicine Shanghai People's Republic of China; Engineering Research Center of Shanghai Colleges for TCM New Drug Discovery Shanghai Peopleʼs Republic of China Department of Pathology and Pathophysiology Fourth Military Medical University Xi'an China Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China. CT Scientific Collaboration, Siemens Healthcare Limited, Shanghai, PR China School of Microelectronics, Fudan University, Shanghai 200433, China; Shanghai Integrated Circuit Manufacturing Innovation Center Co., Ltd., Shanghai 201203, China State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China School of Chemical Engineering and Technology, Tianjin University, Tianjin, Puerto Rico 300350, United States Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University , Chicago, IL, USA; Member of the Oncofertility Consortium, Michigan State University , East Lansing, MI, USA Department of Pediatric General Surgery Shanghai Children’s Medical Center School of Medicine Shanghai Jiao Tong University Shanghai China School of Chinese Medicine, Hong Kong Baptist University, Kowloon Tong, Hong Kong. Genentech, Inc., South San Francisco, CA 94080 Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University /Affiliated Lishui Hospital of Zhejiang University/ The Central Hospital of Zhejiang Lishui, Lishui 323000, China; Department of Radiology, the Fifth Affiliated Hospital of Wenzhou Medical University /Affiliated Lishui Hospital of Zhejiang University/ The Central Hospital of Zhejiang Lishui, Lishui 323000, China Department of Thoracic Surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital and Institute, Shenyang, Liaoning, China From the Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, E-Institute of Shanghai Universities, Shanghai, China (Y.H., Y.B., M.X., Y.X., T.W., M.L., J.L., Y.C., W.W., X.L., G.N.); and Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of... College of Chemistry and Materials Science, Hebei University, Baoding, Hebei Province 071002, P. R. China Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, Sichuan, China Shenzhen Jingtai Technology Co., Ltd. (XtalPi), Shenzhen 518000, China Tianjin University Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212013, P.R. China Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Rui-jin Hospital, Shanghai Jiao-Tong University School of Medicine; Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, China National Clinical Research Center for Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, E-Institute of Shanghai Universities Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, 212008, China; Institute of Digestive Diseases, Jiangsu University, Zhenjiang, Jiangsu, 212013, China Department of Obstetrics, Kunming Maternal and Child Care Hospital, Kunming, Yunnan, China Northwestern University, USA. Department of General Surgery/Surgical Oncology Center Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine Shanghai China Southwestern Institute of Physics, Chengdu 610041, China 1Surgery, Departments of Department of Ophthalmology, Clinical Medical College, Yangzhou University, Yangzhou, China Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commision of the PR China, Shanghai Institute of Endocrine and Metabolic Disease, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Surgery, Washington University School of Medicine, St. Louis, MO. Department of Infectious Disease, State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, National Clinical Research Center for Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine Zhejiang University Hangzhou Zhejiang China Program in Computational Biology and Bioinformatics, Departments of Molecular Biophysics and Biochemistry, Computer Science, and Statistics & Data Science, Yale University, New Haven, CT 06520, USA. Department of Pediatric Intensive Care Unit, Nursing Department, West China Second University Hospital of Sichuan University, Chengdu, Sichuan, China (mainland) Department of Radiology & Medical Imaging, The Affiliated Huai’an Hospital of Xuzhou Medical University, Huaian, China CAS Key Laboratory of Marine Ecology and Environmental Sciences Institute of Oceanology, Chinese Academy of Sciences Qingdao China; Laboratory for Marine Ecology and Environmental Science Qingdao National Laboratory for Marine Science and Technology Qingdao China; Center for Ocean Mega‐Science Chinese Academy of Sciences Qingdao China Department of Neurosurgery, Kunshan Hospital of Traditional Chinese Medicine, Nanjing University of Chinese Medicine, Kunshan, China National Clinical Research Center for Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China College of Chemistry, Key Laboratory for Radiation Physics and Technology of Ministry of Education, Institute of Nuclear Science and Technology, Key State Laboratory of Biotherapy, Sichuan University, Chengdu 610064, China The Key Laboratory of Plant Immunity, Department of Plant Pathology, Nanjing Agricultural University, Nanjing 210095, P. R. China Department of Neurology, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, China. [email protected]. Department of Endocrinology The First Hospital of An Hui Medical University Hefei China Department of Endocrinology, The Second Hospital of Shandong University, Jinan, Shandong 250033, P.R. China The National Engineering Laboratory for Anti‐Tumour Protein Therapeutics Tsinghua University Beijing PR China; Beijing Key Laboratory for Protein Therapeutics Tsinghua University Beijing PR China; Cancer Biology Laboratory, School of Life Sciences Tsinghua University Beijing PR China Liver Cancer Institute, Zhongshan Hospital Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education Shanghai 200032 People's Republic of China Department of Biochemistry and ‡Department of Chemistry, University of Zürich, Winterthurerstrasse 190, Zürich CH-8057, Switzerland Canon Medical System (China) Company Limited,Beijing 100015,China. Department of Biophysics, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, Sichuan 610054, P. R. China College of Food and Bioengineering Xihua University Chengdu China Genomics and Genetic Engineering Laboratory of Ornamental Plants, College of Agriculture and Biotechnology, Zhejiang University , Hangzhou 310058 , China National Clinical Research Center for Metabolic Diseases, Rui Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China Department of Emergency Medicine, Northern Jiangsu People’s Hospital, Yangzhou University College of Clinical Medicine, China Key Laboratory of Cultivation and High-Value Utilization of Marine Organisms in Fujian Province, Fisheries Research Institute of Fujian, Xiamen 361013, China State Key Laboratory of Phytochemistry & Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, People’s Republic of China Southwestern Institute of Physics , Chengdu, Sichuan 610225, China 1 Program in Molecular and Computational Biology, University of Southern California, Los Angeles, CA, USA, 2 Academy of Mathematics and Systems Science, CAS, Beijing 100190, China and 3 Institute of Structural and Molecular Biology, Crystallography, Department of Biological Sciences, Birkbeck College, University of London, London, UK Department of Operating Theatre, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China Department of General Surgery, Shanghai Children’s Medical Center, Shanghai Jiao Tong University School of Medicine, Shanghai 200127, China Department of Biological Chemistry, Merck Research Laboratories, West Point, PA 19486 Drug Clinical Trial Center, Huzhou Central Hospital Affiliated Central Hospital Huzhou University Huzhou Zhejiang China State Key Laboratory of Palaeobiology and Stratigraphy, Nanjing Institute of Geology & Palaeontology Chinese Academy of Sciences Nanjing China Allergy and Lung Health Unit, Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, Faculty of Medicine, Dentistry and Health Sciences, The University of Melbourne, Parkville, Victoria, Australia Department of Otorhinolaryngology Head and Neck Surgery, Xijing Hospital, Air Force Medical University, Xi’an, Shaanxi, China Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China Department of Gynecology, Suzhou TCM Hospital Affiliated to Nanjing University of Chinese Medicine, Suzhou 215009, China Department of Biochemistry, University of Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Institute of Imaging Diagnosis and Minimally Invasive Intervention Research, The Fifth Affiliated Hospital of Wenzhou Medical University , Lishui 323000, China; School of Medicine, Clinical College of The Affiliated Central Hospital, Lishui University , Lishui 323000, China; Department of Radiology, School of Medicine, Lishui Hospital of Zhejiang University , Lishui 323000, China Tianjin Institute of Industrial Biotechnology Chinese Academy of Sciences West 7th Avenue No. 32 300308 Tianjin China Department of Ophthalmology, Northern Jiangsu People's Hospital, Yangzhou, China Department of Information Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China Shanghai Clinical Center for Endocrine and Metabolic Diseases (J.X., X.-Y.L., M.X., J.H., Y.H., J.-R.T., X.L., M.D., G.N.), Shanghai Institute of Endocrinology and Metabolism and Shanghai Key Laboratory for Endocrine Tumors, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, and School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200030, People’s Republic of China Department of Biomedical Engineering School of Medicine, Shenzhen University Shenzhen China; Guangdong Key Laboratory of Biomedical Information Detection and Ultrasound Imaging Shenzhen China; School of Humanities, The University of Hong Kong Pokfulam Road Hong Kong Department of Radiation Oncology, Shandong Cancer Hospital Affiliated to Shandong University, Jinan, Shandong Province, China College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, China; Zhejiang Provincial Key Laboratory for Genetic Improvement and Quality Control of Medicinal Plants, Hangzhou Normal University, Hangzhou, China Department of Hospital Administration, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang, China Department of Liver Surgery, Renji Hospital, School of Medicine,Shanghai Jiao Tong University,Shanghai,China Department of Dermatology Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou China Zhejiang Provincial Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Lishui Hospital of Zhejiang University, Lishui, China.; Department of Radiology, Lishui Hospital of Zhejiang University, Lishui, China. Department of Radiology, The Affiliated Huai'an Hospital of Xuzhou Medical College and Huai'an Second People's Hospital Huaian 223002, China. Departments of Molecular Biology and Pharmacology and Psychiatry, Washington University School of Medicine, St. Louis, MO 63110; Department of Biological Chemistry, Merck Research Laboratories, West Point, PA 19486-0004; Department of Neuropathology and Neuroscience, Graduate School of Pharmaceutical Sciences, University of Tokyo, 7-3-1 Hongo Bunkyoku, Tokyo 113-0033, Japan; Department of Biochemistry and Molecular Biology, Merck Sharp and Dohme Research Laboratories, Neuroscience Research Centre,... Department of Radiation Oncology, Shandong Tumor Hospital, Jinan 250117, China. Computational Biology Department, Carnegie Mellon University , Pittsburgh, PA 15213, USA Guangzhou Eighth People's Hospital, Guangzhou, People's Republic of China Institute for Stem Cell and Neural Regeneration, State Key Laboratory of Reproductive Medicine School of Pharmacy Nanjing Medical University Nanjing China Department of Ultrasound Shengjing Hospital of China Medical University Shenyang 110004 China Department of Oncology, Affiliated Nanhai Hospital of Southern Medical University Foshan, Oncology Section 2, Foshan, Guangdong, China (mainland). School of Physics and Materials Science; Shanghai Key Laboratory of Magnetic Resonance; East China Normal University; Shanghai 200062; P R China Center for Brain Disorders and Cognitive Science, Shenzhen University, Shenzhen 518060, China; Center for Language and Brain, Shenzhen Institute of Neuroscience, Shenzhen 518060, China Department of Neurology, The second People’s Hospital of Deyang City, DeYang, Sichuan, China Merck & Co., Inc., Quantitative Biosciences, Kenilworth, New Jersey, USA Department of Plant Pathology, the Key Laboratory of Plant Immunity Nanjing Agricultural University Nanjing China Department of Child Rehabilitation, Huanggang Pingan and Rehabilitation Hospital Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China Department of Otorhinolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xian Jiaotong University, Xian, Shaanxi 710004, P.R. China Institute of TCM‐Related Comorbid Depression Nanjing P. R. China The Third Affiliated Hospital of Zunyi Medical University (The First People's Hospital of Zunyi) Zunyi China Department of Medical, Midong Branch of People’s Hospital of Xinjiang Autonomous Region , Urumqi , Xinjiang , People's Republic of China Department of Pathology, Xijing Hospital; Department of Pathology and Pathophysiology, and Carnegie Mellon University,Computational Biology Department,Pittsburgh,PA,USA,15213 Pharmacology, ‡Discovery Chemistry, §Screening and Protein Science, ∥Structural Chemistry, and ⊥Infectious Disease Biology, Merck & Co., Inc., West Point, Pennsylvania 19486, United States 8th People's Hospital Guangzhou China Department of Surgery, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiaotong University, Shanghai, 200127, China Xi’an Aerospace Propulsion Test Technology Institute, Xi’an 710100, China Children's Hospital Oakland Research Institute, Oakland, California Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, E-Institute of Shanghai Universities, Shanghai, China; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan 650204, China Key Laboratory of Luminescence and Optical Information, Ministry of Education, Institute of Optoelectronic Technology, Beijing Jiaotong University, Beijing 100044, P. R. China Department of Operating Room, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325000, P. R. China Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research The Fifth Affiliated Hospital of Wenzhou Medical University, Affiliated Lishui Hospital of Zhejiang University, The Central Hospital of Zhejiang Lishui Lishui China State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650204, People’s Republic of China, National Center for Natural Products Research, School of Pharmacy, University of Mississippi, Mississippi 38677, and Weihe Biotech Laboratory, 653100, Yuxi, Yunnan, People’s Republic of China Department of Intensive Care Unit, Second Xiangya Hospital, Central South University, Hunan, P. R. China. Department of Pathology and Pathophysiology, Fourth Military Medical University, P.R. China Department of Hepatology, Guangzhou Eighth People's Hospital Guangzhou Medical University Guangzhou Guangdong China Gyhnecology Department of Second Clinical Medical College of Guangzhou University of CM, Guangzhou 510120, Guangdong Province, China. Shanghai Key Laboratory of Electrical Insulation and Thermal Aging School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai 200240 China Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Lishui Hospital, School of Medicine, Zhejiang University, Lishui 323000, China; Department of Radiology, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China Haiyang Center for Disease Control and Prevention, Haiyang, China. Department of Laboratory Medicine, University of Washington, Seattle, WA, USA; Department of Laboratories, Seattle Children's Hospital, Seattle, WA, USA Research Centre of Characteristic Fruit Tree, College of Horticulture and Forestry, Xinjiang Agricultural University, Urumqi, Xinjiang 830052, China David Braley Center for Antibiotic Discovery, M.G. DeGroote Institute for Infectious Disease Research, Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, ON, Canada. Department of Cardiology The Second Affiliated Hospital Xi’an Jiaotong University Xi’an Shaanxi People’s Republic of China Psychiatric Ward, Qingdao Mental Health Center, Qingdao University, No 299 Nanjing Road, Qingdao, 266034 Shandong, China Fisheries Research Institute of Fujian, Key Laboratory of Cultivation and High-Value Utilization of Marine Organisms in Fujian Province, Xiamen 361013, China Merck & Co., Inc., P.O. Box 4, 770 Sumneytown Pike, West Point, Pennsylvania 19486, United States Department of Hematology, Zhangjiagang First Affiliated Hospital of Soochow University, Zhangjiagang, People’s Republic of China Shanxi Unisdom Testing Technologies Co., Ltd. Taiyuan China Molecular and Cellular Technology, and 1 Program in Molecular and Computational Biology, University of Southern California, Los Angeles, CA 90089, USA and 2European Molecular Biology Laboratory, Computational and Structural Biology Unit, Meyerhofstrasse 1, 69117 Heidelberg, Germany Department of Physiology, Tufts University School of Medicine, Boston, Massachusetts 02111; Beth Israel Hospital and Department of Microbiology and Molecular Biology, , Harvard Medical School, Boston, Massachusetts 02115 Shanghai Engineering Research Center of Ultra-Precision Optical Manufacturing, Fudan University, Shanghai, China Jiangsu Key Laboratory for Molecular and Medical Biotechnology, College of Life Sciences Nanjing Normal University Nanjing PR China Key Laboratory of Environment Correlative Dietology, Ministry of Education College of Food Science and Technology, Huazhong Agricultural University Wuhan 430070 China * Ophthalmology, Research Center of Clinical Medicine, Research Center of Clinical Immunology Affiliated Hospital of Nantong University Nantong China Department of Pediatrics, Sixth People's Hospital Affiliated to Shanghai Jiao Tong University, Shanghai 200233, China. Department of Radiology, The Xi’an Municipal Central Hospital, Affiliated Hospital of Xi’an Jiaotong University, Xi’an, PR China Department of Hematology and Oncology, Wuhan Children's Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China State Key Laboratory of Natural Medicines Jiangsu Key Laboratory of Carcinogenesis and Intervention China Pharmaceutical University School of Information Science and Technology, Fudan University Shanghai Rui-Jin Hospital (M.Y., M.C., J.W., M.X., L.D., X.L., Q.M., Y.B., R.L., J.H., G.N.), Shanghai Jiao-Tong University School of Medicine, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases and Shanghai E-institute for Endocrinology, Shanghai 200025, China; Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, E-Institute of Shanghai Universities; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine State Key Laboratory of Phytochemistry and Plant Resources of West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China Department of Anatomy, Liaoning Key Laboratory of Diabetic Cognitive and Perceptive Dysfunction Jinzhou Medical University Jinzhou Liaoning Province China CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Precision Machinery and Precision Instrumentation, University of Science and Technology of China, Hefei 230026, China Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Department of Periodontology Peking University School and Hospital of Stomatology & National Center of Stomatology & National Clinical Research Center for Oral Diseases & National Engineering Laboratory for Digital and Material Technology of Stomatology & Beijing Key Laboratory of Digital Stomatology & Research Center of Engineering and Technology for Computerized Dentistry Ministry of Health & NMPA Key Laboratory for Dental Materials Beijing China Key Laboratory of Cultivation and High-Value Utilization of Marine Organisms in Fujian Province, Fisheries Research Institute of Fujian, National Research and Development Center for Marine Fish Processing (Xiamen), Xiamen 361013, China Key Laboratory of Cultivation and High-Value Utilization of Marine Organisms in Fujian Province, National Research and Development Center for Marine Fish Processing (Xiamen), Fisheries Research Institute of Fujian, Xiamen 361013, China; College of Ocean Food and Biological Engineering, Jimei University, Xiamen 361021, China Center for Transport Phenomena, Energy Research Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250014, China Natural Antibodies, Inc., Boston, MA 02115; and Departments of Pathology, Surgery, and Pediatrics, Harvard Medical School, CBR Institute for Biomedical Research, Brigham and Women's Hospital, and Massachusetts General Hospital, Boston, MA 02115 State Key Laboratory of Medical Genomics Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, the Chinese Clinical Research Center for Metabolic Diseases, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai China; Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai China Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Clinical and Research Centre of Thrombosis and Hemostasis, Wuhan 430022, China CT Business Unit, Canon Medical Systems (China), Beijing, China. State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, Chinese Clinical Research Center for Metabolic Diseases, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China; Department of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital Shanghai Jiaotong University School of Medicine Shanghai China Key Laboratory of Specialty Agri‐product Quality and Hazard Controlling Technology of Zhejiang Province, College of Life Sciences China Jiliang University Hangzhou People's Republic of China Institute of Neuroscience, State Key Laboratory of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, China. Department of Cardiology Renmin Hospital of Wuhan University Wuhan PR China; Cardiovascular Research Institute of Wuhan University Wuhan PR China; Hubei Key Laboratory of Cardiology Wuhan PR China College of Pharmacy, Chengdu University of Traditional Chinese Medicine, Chengdu 611137, China Department of Hematology, Zhangjiagang First People's Hospital, Suzhou, 215600, P. R. China. School of Electrical and Information Engineering of Jiangsu University Zhenjiang China; School of Electronic Engineering, Changzhou College of Information Technology Changzhou Jiangsu China Department of Pediatric Surgery Shanghai Children's Medical Center, School of Medicine Shanghai Jiaotong University Shanghai China School of Pharmacy, Collaborative Innovation Center for Cardiovascular Disease Translational Medicine, State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, China Institute of Corpus Studies and Applications, Shanghai International Studies University, China Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. Department of Cardiology The Second Affiliated Hospital, Xi'an Jiaotong University Xi'an P.R. China State Key Laboratory of ASIC and System, School of Microelectronics, Fudan University, Shanghai 200433, China Nanjing Medical University 2 Department of Neurobiology, Key Laboratory of Human Functional Genomics of Jiangsu , , Nanjing, Jiangsu , China , 211166 1Department of Gastrointestinal Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Computational Biology Department Carnegie Mellon University Pittsburgh PA 15213 USA Department of Cardiology, The Second Affiliated Hospital Xi'an Jiaotong University Xi'an Shaanxi China Laboratory of Virology, Department of Plant Sciences, Wageningen University and Research, Droevendaalsesteeg 1, 6708PB Wageningen, The Netherlands Department of Anesthesiology, Xiangyang No.1 People's Hospital, Hubei University of Medicine, Xiangyang, Hubei 441000, P.R. China Carnegie Mellon University,Computational Biology,Pittsburgh,PA,USA,15213 Department of Pathology and Laboratory Medicine, University of Cincinnati Medical Center, Cincinnati, Ohio Chinese Education Ministry's Key Laboratory of Western Resources and Modern Biotechnology, Key Laboratory of Biotechnology Shaanxi Province, College of Life Sciences, Northwest University , Xi’an , China School of Chinese Medicine Hong Kong Baptist University Hong Kong SAR P. R. China 8th People's Hospital; Guangzhou China Department of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China (mainland) Department of Neurosurgery, Kunshan Hospital of Traditional Chinese Medicine, Kunshan Affiliated Hospital of Nanjing University of Chinese Medicine, Suzhou, China Reproductive Medical Center, The Second Affiliated Hospital of Zhengzhou University, Henan Province, China 8th People's Hospital, Guangzhou, China. Science and Technology on Vacuum Technology and Physical Laboratory, Lanzhou Institute of Physics, Lanzhou 730000, China Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai, China; Department of Oncology, Affiliated Nanhai Hospital of Southern Medical University Foshan, Oncology Section 2, Foshan, Guangdong, China (mainland) Department of of Biochemistry, University of Zürich, Winterthurerstrasse 190, CH-8057, Zürich, Switzerland Department of Rehabilitation, Guizhou Provincial People’s Hospital, Guiyang, Guizhou, China National Clinical Research Center for Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Shanghai China; Department of Endocrine and Metabolic Diseases Rui‐Jin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Gynecology; Guangdong Provincial Hospital of TCM; Guangzhou China College of Science & Technology; Ningbo University; Ningbo 315300; P. R. China Department of Neurology the Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou China; Department of Neurology the Second Affiliated Hospital of Zhejiang Chinese Medical University Hangzhou China School of Chinese Medicine, Hong Kong Baptist University, Hong Kong, China. Department of Health Economics, Institute of Medical Information, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China. Department of Pediatrics Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China; China Hospital Development Institute Shanghai Jiao Tong University Shanghai China College of Life and Environmental Sciences, Hangzhou Normal University, Hangzhou, 310036, China; Zhejiang Provincial Key Laboratory for Genetic Improvement and Quality Control of Medicinal Plants, Hangzhou Normal University, Hangzhou, 310036, China Genentech Inc., Department of Microbial Pathogenesis, South San Francisco, California, USA Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China; Shanghai National Clinical Research Center for Endocrine and Metabolic Diseases, State Key Laboratory for Endocrine and Metabolic Diseases, State Key Laboratory for Endocrine Tumor, State Key Laboratory for Medical Genomics Ruijin Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine E‐Institute of Shanghai Universities Shanghai China; Department of Endocrine and Metabolic Diseases Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Rui Jin Hospital Shanghai JiaoTong University School of Medicine Shanghai China Department of Surgery Shanghai Children's Medical Center Shanghai Jiaotong University School of Medicine Shanghai China Department of Radiology, The Fifth Affiliated Hospital of Wenzhou Medical University, Affiliated Lishui Hospital of Zhejiang University, The Central Hospital of Zhejiang Lishui, Lishui, Zhejiang, P.R. China Department of Endocrine and Metabolic Diseases, Rui-jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Endocrine and Metabolic E-Institutes of Shanghai Universities, and Key Laboratory for Endocrinology and Metabolism of Chinese Health Ministry, Shanghai 200025, Chin Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, Jiangsu, China Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, the Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui, Lishui 323000, China Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China Shanghai Engineering Research Center of Ultra-Precision Optical Manufacturing, School of Information Science and Technology, Fudan University, Shanghai 200438, China Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China; Shanghai National Clinical Research Center for metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China Shanghai National Center for Translational Medicine Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China School of Pharmacy Nanjing Medical University Nanjing Jiangsu China Department of Gynecology and Obstetrics, West China Second Hospital, Sichuan University, Chengdu 610041, China. Department of Otorhinolaryngology-Head and Neck Surgery, 2nd Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an 710004, Shaanxi Province, China. Department of Neurosurgery, Kunshan Hospital of Traditional Chinese Medicine, Kunshan Affiliated Hospital of Nanjing University of Chinese Medicine , No. 189 Chaoyang Road , Kunshan City , Jiangsu Province, 215300 , China College of Veterinary Medicine, Sichuan Agricultural University, Chengdu 611130, China Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals, Zhejiang University of Technology Academy of Integrative Medicine, College of Pharmacy, Key Laboratory of Pharmacokinetic and Drug Transport of Liaoning Dalian Medical University Dalian China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Key Laboratory for Endocrine Tumors and E-Institute for Endocrinology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Guangdong Provincial Key Laboratory of Biotechnology for Plant Development, School of Life Sciences South China Normal University (SCNU) Guangzhou 510631 China Department of Pharmacology, Southeast University, Nanjing 210009, China. Department of Urology, Affiliated Jinhua Hospital, Zhejiang University School of Medicine, Jinhua, China Department of Gastroenterology, Shanghai First People’s Hospital, Shanghai JiaoTong University, Shanghai, China Department of Physics, Fairfield University, Fairfield, CT 06824 USA Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Guangdong Key Laboratory of Genome Instability and Human Disease Prevention Department of Biochemistry and Molecular Biology Shenzhen University School of Medicine Shenzhen China Institute for Stem Cell and Neural Regeneration, Key Laboratory of Targeted Intervention of Cardiovascular Disease, School of Pharmacy, Nanjing Medical University, Nanjing 211166, China Department of Echocardiography The Third Affiliated Hospital of Soochow University Changzhou City China Key Laboratory of Functionalized Molecular Solids, Ministry of Education, Anhui Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science, Anhui Normal University, 189 South Jiuhua Road, Wuhu, Anhui 241002, P. R. China Department of Pediatrics, The People's Hospital of Yucheng City, Dezhou, China Shenzhen Yuanwei Medical Equipment Co. Ltd., Shenzhen 518116, China. College of Pharmacy, Chengdu University of Traditional Chinese Medicine, No. 1166, Liutai Road, Wenjiang District, Chengdu 611137, China Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research, Lishui Hospital of Zhejiang University, The Fifth Affiliated Hospital of Wenzhou Medical University, Lishui 323000, China College of Environmental Science and Engineering, Hunan University, Changsha 410082, China. [email protected] State Key Laboratory of ASIC and System, Shanghai Institute of Intelligent Electronics & Systems, School of Microelectronics, Fudan University, Shanghai 200433, China; Shanghai Integrated Circuit Manufacturing Innovation Center Co., Ltd., Shanghai 200433, China State Key Laboratory of Medical Genomics, Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health, National Clinical Research Center for Metabolic Diseases, Collaborative Innovation Center of Systems Biomedicine, and Shanghai Clinical Center for Endocrine and Metabolic Diseases Rui‐Jin Hospital, Shanghai Jiao‐Tong University School of Medicine Shanghai China; Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrine and Metabolic Diseases Rui‐Jin Hospital, Shanghai Jiao‐Tong University School of Medicine Shanghai China China Light Industry Key Laboratory of Meat Microbial Control and Utilization, School of Food and Biological Engineering, Engineering Research Center of Bio-process, Ministry of Education, Hefei University of Technology, Hefei 230009, P. R. China Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases (R.Z., Y.X., M.L., J.L., Shujing Wu, J.N., Z.Z., M.X., T.W., S. Wang, H.L., Y.C., Y.B., G.N., W.W.); Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics (R.Z., Y.X., M.L., J.L., Shujing Wu, J.N., Z.Z., M.X., T.W., S. Wang, H.L., Y.C., Y.B., G.N., W.W.), Ruijin Hospital, Shanghai Jiaotong University School of Medicine, China. the Department of Surgery, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania. Department of Gastroenterology Affiliated Hospital of Jiangsu University Jiangsu Province China Institute of Blood Transfusion, Chinese Academy of Medical Sciences and the Sichuan Blood Safety and Blood Substitute International Science and Technology Cooperation Base Chengdu China Center for Higher Brain Functions, Department of Neurobiology, Capital Medical University, Beijing, China Department of Cardiovascular medicine, The Third Affiliated Hospital of Zunyi Medical University (The First People’s Hospital of Zunyi), Zunyi, Guizhou, 563002, P.R. China 1Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; 2Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the People’s Republic of China, Shanghai Jiao Tong University School of Medicine, Shanghai, China; 3Shanghai Key Laboratory for Endocrine Tumor, State Key Laboratory of Medical Genomics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China School of Health Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China Department of Pediatric transplantation, Organ Transplantation Center Tianjin First Central Hospital Tianjin China Department of Radiation Oncology, Shandong Cancer Hospital & Institute, Jinan 250117, China. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, P. R. China †Department of Immunology, Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China; Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China Shanghai National Center for Translational Medicine Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China National Key Laboratory of Plant Molecular Genetics Institute of Plant Physiology and Ecology Shanghai Institutes for Biological Sciences Chinese Academy of Science 300 Fenglin Road Shanghai 200032 China Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu, China; Digestive Disease Research Institute, Jiangsu University, Zhenjiang, Jiangsu, China. Institute of Blood Transfusion, Chinese Academy of Medical Sciences and Peking Union Medical College, Chengdu, China From the Departments of Nutrition (M.X., Q.Q., F.B.H., F.M.S., L.Q) and Epidemiology (F.B.H.), Harvard School of Public Health, Boston, MA; Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Department of Endocrinology and Metabolism, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China (M.X.); Department of Endocrinology, Central Hospital of Xuzhou, Affiliated Hospital of Southeast... Shanghai Clinical Center for Endocrine and Metabolic Diseases and Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Physics, Wenzhou University, Wenzhou 325035, China Laboratory of Fruit Quality Biology/Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology Zhejiang University Zijingang Campus Hangzhou 310058 China Department of Ophthalmology, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania Departments of Medicinal Chemistry, Biological Chemistry, Structural Biology and Molecular Systems, Merck Research Laboratories, West Point, Pennsylvania 19486-0004, and Department of Chemistry, NeoGenesis Pharmaceuticals, 840 Memorial Drive, Cambridge, Massachusetts 02139 State Key Laboratory of Lake Science and Environment Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences Nanjing China Hongqiao International Institute of Medicine, China; Obstetrics and Gynecology Department, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, No. 1111, XianXia Road, Shanghai 200336, China Affiliated Hospital of Chengde Medical University, Intensive Care Unit , Chengde , China Department of Gastroenterology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu 212000, P.R. China State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, Yunnan, P. R. China, and University of Chinese Academy of Sciences, Beijing 100049, P. R. China Department of Translational Immunology, Genentech, Inc., South San Francisco, California, USA Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Center of Clinical Laboratory, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China Department of Radiology, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China Sino-Medic, Hefei, Anhui Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai Key Laboratory for Endocrine Tumor, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Laboratory Medicine, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China; Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou, China Department of Dermatology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China College of Animal Science and Technology, Sichuan Agricultural University, Ya'an 625014, China. [email protected] Shangti Health Technology (Shanghai) Co., Ltd., Shanghai, China Department of Surgery, Section of Abdominal Transplantation, Washington University School of Medicine, St. Louis, MO. Beijing Anzhen Hospital, Beijing Institute of Heart, Lung and Blood Vessel Diseases Capital Medical University Beijing China Computational Biology Department, School of Computer Science, Carnegie Mellon University, Pittsburgh, PA, USA Department of General Medicine Jiangsu Province Official Hospital Nanjing China Department of Liver Surgery, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research The Fifth Affiliated Hospital of Wenzhou Medical University/Affiliated Lishui Hospital of Zhejiang University/The Central Hospital of Zhejiang Lishui Lishui China Shanghai Jiao Tong University Anhui Vocational College of Grain Engineering, Hefei, China Department of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, People's Republic of China.; Key Clinical Laboratory of Henan Province, Zhengzhou, People's Republic of China.; Department of Laboratory Medicine, Zhengzhou University, Zhengzhou, People's Republic of China. Department of Gastroenterology, Shanghai General Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China Key Laboratory of Soil Environment and Pollution Remediation, Institute of Soil Science, Chinese Academy of Sciences, 71 East Beijing Road, Nanjing, Jiangsu 210008, People’s Republic of China School of Chemical Engineering & Technology, Tianjin University, Tianjin 300350, China Department of Nuclear Medicine, Cancer Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, China. [email protected] Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing 210009, China. Shanghai PerioImplant Innovation Center, Department of Oral and Maxillofacial Implantology Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China; College of Stomatology, Shanghai Jiao Tong University Shanghai China; National Center for Stomatology Shanghai China; National Clinical Research Center for Oral Diseases Shanghai China; Shanghai Key Laboratory of Stomatology Shanghai China Translational Immunology, Genentech , South San Francisco, California, USA 1Institute of Hematology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Department of Gastroenterology, Digestive Disease Institute of Jiangsu University, Affiliated Hospital of Jiangsu University, Zhenjiang, China Northeast Institute of Geography and Agroecology, Key Laboratory of Soybean Molecular Design Breeding Chinese Academy of Sciences Harbin 150081 China; University of Chinese Academy of Sciences Beijing 100049 China Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Illinois.; The Robert H. Lurie Comprehensive Cancer Center of Northwestern University, Chicago, Illinois. Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, Jinan 250117, China Department of Pharmacology and Laboratory of Cerebrovascular Pharmacology, College of Pharmaceutical Science, Soochow University, Suzhou 215123, China State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, PR China State Key Laboratory of Microbial Metabolism, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, China Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China;Shanghai National Clinical Research Center for Metabolic Diseases, Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of the PR China, Shanghai National Center for Translational Medicine, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. Key Laboratory for Endocrine and Metabolic Diseases of Ministry of Health Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine E‐Institute of Shanghai Universities Shanghai China; Shanghai Clinical Center for Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic Diseases Department of Endocrinology and Metabolism Rui‐Jin Hospital Shanghai Jiao‐Tong University School of Medicine Shanghai China Oklahoma Medical Research Foundation, 825 NE 13th Street, Oklahoma City, OK 73104, USA. College of Materials & Environmental Engineering; Hangzhou Dianzi University; Hangzhou; P. R. China Department of Translational Immunology, Genentech, Inc., South San Francisco, CA 94080; Departments of Echocardiography, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu 213003, P.R. China Department of Surgery, University of Pennsylvania, Philadelphia, Pennsylvania; and the Department of Physics, Zhejiang Cancer Hospital, Zhejiang Hangzhou, People’s Republic of China Shanghai Key Laboratory of Magnetic Resonance, Department of Physics; East China Normal University; Shanghai China State Key Laboratory of Cryospheric Science, Northwest Institute of Eco-Environment and Resources, Chinese Academy of Sciences, Lanzhou 730000, China Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington; Department of Laboratories, Seattle Children’s Hospital, Seattle, Washington Laboratory of Reproductive Medicine, Center of Human Functional Genomics, Nanjing Medical University, People's Republic of China. |
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