http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_1ed5ed6ebd7bca1be56a0a7072a6e9d0
Outgoing Links
| Predicate | Object |
|---|---|
| family-name | Li Ming Li |
| name | Ming Li |
| given-name | Ming |
| organization-name | Department of Medical Imaging, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China Key Laboratory of Industrial Biotechnology, Ministry of Education, State Key Laboratory of Food Science and Technology, School of Biotechnology, Jiangnan University, Wuxi, China State Key Laboratory of Metal Matrix Composites, School of Material Science and Engineering, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Shanghai 200240, China Department of Orthopaedic Surgery, Changhai Hospital, Shanghai, China State Key Laboratory Base of Eco-Chemical Engineering; College of Chemistry and Molecular Engineering; Qingdao University of Science and Technology; Qingdao 266042; P. R. China Beihang University, China Department of Materials, Laboratory of Polymer Chemistry, ETH Zürich, Wolfgang-Pauli Strasse 10, CH-8093 Zürich, Switzerland Department of Dermatology Zhongshan Hospital Fudan University Shanghai China Department of Orthopaedics, Qingdao Huangdao District Hospital of Traditional Chinese Medicine, Qingdao, China College of Chemistry Sichuan University Chengdu 610064 P. R. China Anhui Province Key Laboratory of Veterinary Pathobiology and Disease Control, Anhui Agricultural University, Hefei, Anhui, China Department of Microecology College of Basic Medical Science Dalian Medical University Dalian China Department of Orthopedics, Chinese PLA General Hospital; National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation State Key Lab of New Ceramics and Fine Processing, School of Materials Science and Engineering, Tsinghua University, Beijing, 100084, China College of Chemistry and Chemical Engineering, Yantai University, Yantai, 264005, People's Republic of China State Key Laboratory of Transient Optics and Photonics, Xi’an Institute of Optics and Precision Mechanics, Chinese Academy of Sciences, Xi’an 710119, China Department of Traumatic Orthopaedics, Ningbo No. 6 Hospital, Ningbo, China Department of Forensic Pathology Zhongshan School of Medicine Sun Yat‐sen University Guangzhou 510080 China Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University); Ministry of Education; School of Chemistry and Chemical Engineering; Southwest University; Chongqing 400715 Jiangsu Key Laboratory of Oral Diseases, Nanjing Medical University, Department of Oral and Maxillofacial Surgery, Affiliated Hospital of Stomatology, Nanjing Medical University, Nanjing, Jiangsu Province, China. From the Departments of *Radiology and †Rheumatology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing; ‡Philips Healthcare, Shanghai; and §Philips Healthcare, Hong Kong, P.R. China. Wuhan Fourth Hospital, Wuhan, China Nanoscale Science and Technology Laboratory Institute for Advanced Study Nanchang University Nanchang Jiangxi People's Republic of China; College of Life Sciences Nanchang University Nanchang Jiangxi People's Republic of China Department of Pediatrics University of Arkansas for Medical Sciences; Little Rock Arkansas United States of America Department of Plastic Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, P.R. China State Key Laboratory of Structural Analysis Optimization and CAE Software for Industrial Equipment Department of Engineering Mechanics, School of Mechanics and Aerospace Engineering Dalian University of Technology Dalian 116024 China Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China; Eight-Year Program Clinical Medicine, Grade of 2014, Shanghai Medical College, Fudan University, Shanghai, China Department of Orthopedics, the First People’s Hospital of Jiashan, Zhejiang Province, China. Department of Orthopedics, Shanghai Changhai Hospital, Shanghai, China State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry University of Chinese Academy of Sciences Chinese Academy of Sciences 345 Lingling Road Shanghai 200032 China Beijing National Laboratory for Condensed Matter Physics and Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China Department of Dermatology Xinhua Hospital Shanghai Jiaotong University School of Medicine Shanghai China; Institute of Dermatology Shanghai Jiaotong University School of Medicine Shanghai China College of Natural Resource and Environment, Northwest A&F University, Yangling 712100, China. School of Computer Science, University of Waterloo, Waterloo, ON, Canada. Department of Endocrinology, Second Xiangya Hospital, Central South University, Changsha 410011, China. Key Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China Key Laboratory of Eco‐Chemical Engineering, Ministry of Education, College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 Shandong People's Republic of China Institute of Toxicology; School of Public Health; Shandong University; Jinan; China Stated Key Laboratories for Agrobiotechnologies, College of Biological Sciences, China Agricultural University, Beijing. Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China Hubei Key Laboratory of Animal Nutrition and Feed Science, Wuhan Polytechnic University, Wuhan, China, and State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China Infectious Diseases Translational Research Programme, Department of Biochemistry, National University of Singapore , Singapore , Singapore School of Biotechnology, Southern Medical University, Shatai Southern Road 1023, Baiyun District, Guangzhou, Guangdong 510515, China School of Computer Science, Civil Aviation University of China, Tianjin, China State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China. Fax: +86 21-64252920, Tel: +86 21-64251655 Key Laboratory of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences Beijing China Laboratory of Molecular Genetics of Aging and Tumour, Medical School, Kunming University of Science and Technology, Chenggong Campus, Kunming, Yunnan 650500, China Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Key Laboratory of Nephrology, Ministry of Health, Guangzhou, Guangdong, China; College of Chemistry and Chemical Engineering; Southwest University; Chongqing 400715; P.R. China Department of Orthopaedic Surgery, Hong Hui Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi 710054, P.R. China Department of Thoracic Surgery, Jiangsu Cancer Hospital, Nanjing, People's Republic of China. Institute of New Energy Material Chemistry, College of Chemistry, Institute of Scientific Computing, Nankai University, Tianjin 300071, P. R. China, and Department of Chemistry, Institute for Functional Nanomaterials, University of Puerto Rico, San Juan, PR 00931, U.S.A. State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, P. R. China Shanghai Key Laboratory of Plant Molecular Sciences College of Life Sciences Shanghai Normal University Shanghai China Department of Vascular Surgery, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China; Vascular Disease Institute, Central South University, Changsha, Hunan, China Department of Orthopaedic Surgery, Honghui Hospital, Xi’an Jiaotong University, Xi’an 710054, China Department of Respiratory Medicine, Kunming Children’s Hospital , China Department of Microecology School of Basic Medical Science Dalian Medical University Dalian China College of Material Science and Engineering; Jinling Institute of Technology; Nanjing 211169; People's Republic of China *CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China; Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China 1Department of Thoracic Surgery, Nanjing Medical University Affiliated Cancer Hospital, Nanjing, China.; 2Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Cancer Institute of Jiangsu Province, Nanjing, China. Tianjin Key Laboratory of Food Biotechnology, College of Biotechnology and Food Science Tianjin University of Commerce Tianjin China School of Life Sciences, Jiangsu University, Zhenjiang, China Department of Orthopaedic Surgery The Third Hospital of Hebei Medical University Shijiazhuang China Department of Dermatology, Children's Hospital of Fudan University, Shanghai, China. Institute of Applied Electronics, China Academy of Engineering Physics (CAEP), Mianyang, China Institute of Radiation Medicine, AMMS, Beijing 100850, China Department of spine surgery Shanghai Changhai Hospital Shanghai China Department of Gastroenterology Shandong University Qilu Hospital Jinan China State Key Laboratory of Oil and Gas Reservoir Geology and Exploitation, Southwest Petroleum University, Chengdu 610500, China c Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University , Daqing163319, Heilongjiang , China Sun Yat-sen University Pharmaceutical College Henan University Kaifeng China School of Sciences and State Key Laboratory of Natural Medicines China Pharmaceutical University Nanjing China Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Diabetes Research Center of Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Wangfujing Street, Dongcheng District, Beijing 100730, China Section of Cell and Developmental Biology, University of California, San Diego, La Jolla, CA 92093; Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100080, China College of Forestry, Northeast Forestry University, Harbin 150040, China Department of Mechanical, Materials and Manufacturing Engineering, University of Nottingham, Nottingham NG7 2RD, U.K. Institute of Antibody Engineering School of Laboratory Medicine and Biotechnology Southern Medical University Guangzhou China State Key Laboratory of Organometallic Chemistry and Shanghai-Hong Kong Joint Laboratory in Chemical Synthesis, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China Department of Dermatology, Zhongshan Hospital, Fudan University, Shanghai, China Department of Hepatobiliary Surgery, Xiang’an Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, Fujian 361102, P. R. China; Xiamen University Research Center of Retroperitoneal Tumor Committee of Oncology Society of Chinese Medical Association, Xiamen University, Xiamen, Fujian 361102, P. R. China Department of Orthopedics Trauma, Honghui Hospital Affiliated to School of Medicine Xi'an Jiaotong University Xi'an China Center of Laboratory Medicine of Huashan Hospital, Shanghai Medical College, Fudan University Chongqing Research Center for Pharmaceutical Engineering College of Pharmacy Chongqing Medical University Chongqing 400016 P. R. China Hunan Key Laboratory of Oral Health Research, Hunan Clinical Research Center of Oral Major Diseases and Oral Health, Xiangya Stomatological Hospital, Xiangya School of Stomatology Central South University Changsha China School of Public Health, Sichuan University, Chengdu 610041, China. Neuro-Oncology Division, Department of Neurology, University of Virginia, Charlottesville, VA, USA; The Experiment Center, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China Biostatistics and Bioinformatics Core Facility, Case Comprehensive Cancer Center, School of Medicine, Case Western Reserve University, Cleveland, Ohio, USA Pudong New Area Health and Family Planning Commission Shanghai 200125 China State Key Laboratory of Metal Matrix Composites; School of Material Science and Engineering; Shanghai Jiao Tong University; Shanghai; PR China Department of Orthopaedics, The Fourth Medical Center of the Chinese PLA General Hospital, Beijing 100853, China; National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, Beijing 100853, China University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania, USA School of Chemistry and Chemical Engineering, Southwest China Normal University, 400715, Chongqing, China Department of Orthopaedics, Chinese PLA General Hospital, Beijing 100853, China Centre for Inflammatory Diseases, Department of Medicine, Monash University, Monash Medical Centre, Clayton, Victoria, Australia National Engineering Research Center of Plant Space Breeding South China Agricultural University Guangzhou 510642 China Key Laboratory of Unconventional Oil and Gas Development (China University of Petroleum (East China)), Ministry of Education, School of Petroleum Engineering, China University of Petroleum (East China), Qingdao 266580, People's Republic of China Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou - China Department of Urology, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, P.R. China School of Information and Control Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China Department of Dental Implantology Affiliated Stomatological Hospital of Nanjing Medical University Nanjing Jiangsu Province China Department of Orthopaedics, Ningbo 6th Hospital, Ningbo 315040, Zhejiang, China. Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, P. R. China Shanghai Jiaotong University, Shanghai Institute of Diabetes, Shanghai Diabetic Clinical Center, Shanghai 200233, China. Key Laboratory of Aquaculture Disease Control, Ministry of Agriculture, and State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, People's Republic of China. UCL Institute of Child Health, London, UK Department of Urology Shandong Provincial Hospital Shandong China Department of Colorectal Surgery and Oncology, Key Laboratory of Cancer Prevention and Intervention, Ministry of Education, The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang China; Zhejiang University Cancer Center Hangzhou Zhejiang China Department of Gastroenterology, Shandong University, Qilu Hospital, Jinan, Shandong 250012, P.R. China Key Laboratory of Endocrinology Translational Medicine Center Ministry of Health Department of Endocrinology Peking Union Medical College Hospital Diabetes Research Center of Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China Department of Biology, University of Massachusetts, Amherst, MA 01003; and Key Laboratory of Nutrition and Metabolism, Institute for Nutritional Sciences, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai 200031, China Hefei National Laboratory for Physical Sciences at the Microscale; University of Science and Technology of China; Hefei; People's Republic of China Cell Therapy Center, 323 Hospital of Chinese People's Liberation Army, Xi'an 710054, China State Key Laboratory of Pulp and Paper Engineering, South China University of Technology, Guangzhou 510640, China Key Laboratory of Marine Medicine, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China, Qingdao 266003, China; Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology, Qingdao 266237, China Department of Psychology, Beijing Normal University, Beijing, China Pharmacokinetics, Dynamics & Metabolism, Pfizer Global Research and Development, Pfizer Inc., Groton, CT 06340, USA Department of Veterinary and Biomedical Sciences State Key Laboratory of Freshwater Ecology and Biotechnology, and Key Labatory of Aquaculture Disease Control, Ministry of Agriculture, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China; Protist 10,000 Genomics Project (P10K) Consortium, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, China Genetic Section of Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, OKC, USA; Department of Orthopaedics, Shanghai Changhai Hospital Navy Medical University Shanghai China Department of Computer Science, University of California, 93106, Santa Barbara, California, USA Department of Epidemiology, Research Institute for Medicine of Nanjing Command, Nanjing 210002, China; Department of Microbiology, Third Military Medical University, Chongqing 630030, China Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, P.R. China.; Key Laboratory of Nephrology, National Health Commission and Guangdong Province, Guangzhou, P.R. China. Institute of Biotechnology, Academy of Military Medical Science, Beijing 100071, China. [email protected] Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China; Cardiovascular Research Institute, Wuhan University, Wuhan, China; Hubei Key Laboratory of Cardiology, Wuhan, China Department of Orthopaedics, The First Medical Center of the Chinese PLA General Hospital, No. 28 Fuxin Road, Beijing 100853, China; National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, No. 28 Fuxin Road, Beijing 100853, China Department of Clinical Laboratory Shandong Provincial Hospital Cheeloo College of Medicine Shandong University Jinan China; Department of Orthopaedics Shandong Provincial Hospital Cheeloo College of Medicine Shandong University Jinan China State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China Department of Urology Shengjing Hospital of China Medical University Shenyang Liaoning China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, Wuhan University of Technology, Wuhan 430070, China Key Lab New Processing Technology for Nonferrous Metals & Materials Ministry of Education, College of Matertials Science and Engineering, Guilin University of Technology, Guilin541004, Guangxi, China Department of Orthopaedics Chinese PLA General Hospital Beijing China; National Clinical Research Center for Orthopedics Sports Medicine and Rehabilitation Beijing China Department of Bioinformatics, School of Basic Medical Sciences Southern Medical University Guangzhou China Department of Hepatology The Affiliated Infectious Diseases Hospital of Soochow University Suzhou China Department of Neurosurgery, China National Clinical Research Center for Neurological Diseases (NCRC-ND), Beijing Tiantan Hospital, Capital Medical University;; Beijing Key Laboratory of Brain Tumor, Beijing Tiantan Hospital, Capital Medical University; Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences & Yunnan Province Kunming Institute of Zoology Chinese Academy of Sciences Kunming Yunnan 650204 China Hubei Key Laboratory of Regional Development and Environmental Response, Hubei University, Wuhan 430061, China Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, and Key Laboratory of Colloid and Interface Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, 100084, Beijing, China Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education), Department of Chemistry, Tsinghua University, Beijing 100084, China, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao, Shandong 266042, China, and Department of Applied Chemistry, China Agricultural University, Beijing 100193, China Department of Radiology Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing People's Republic of China Biodel Inc., Danbury, Connecticut Center for Reproductive Medicine, Cheeloo College of Medicine Shandong University Jinan Shandong China Institute of Zoology, Chinese Academy of Sciences, Beijing, 100080, P.R. China, School of Environmental Biological Science Technology, Dalian University of Technology, Dalian, Liaoning, 116024, P.R. China, and Research Institute for Environmental Sciences and Public Health of Iwate Prefecture, Morioka, Iwate, Japan MRI Center, Department of Physics University of New Brunswick PO Box 4400 Fredericton NB E3B 5A3 Canada; Department of Chemical Engineering University of New Brunswick PO Box 4400 Fredericton NB E3B 5A3 Canada National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences, P.R. China Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China. Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University , Yangling 712100 , China College of Chemistry and Chemical Engineering, Shanghai University of Engineering Science, Shanghai 201620, China Department of Orthopaedics, First Medical Center, Chinese PLA General Hospital National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation Beijing China Department of Orthopedics and Trauma, Peking University People’s Hospital, Beijing, China Department of Orthopaedic Surgery, Hong Hui Hospital, Xi'an Jiaotong University College of Medicine, Xi'an, Shaanxi Province, China School of Radiation Medicine and Protection Medical College of Soochow University Suzhou China; State Key Laboratory of Radiation Medicine and Protection and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University Suzhou China Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai; and Department of Radiology Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School Nanjing P.R. China Department of Orthopaedic Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China. Department of Mechanical and Aerospace Engineering, WVNano Initiative, ‡Eugene Bennett Department of Chemistry, and §Lane Department of Computer Science and Electrical Engineering, West Virginia University, Morgantown, West Virginia 26506, United States Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China Key Laboratory of Materials Physics Anhui Key Laboratory of Nanomaterials and Nanotechnology Institute of Solid State Physics Chinese Academy of Sciences University of Science and Technology of China Hefei 230031 P. R. China Key Laboratory of Luminescent and Real-Time Analytical Chemistry (Southwest University), Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, P. R. China Medical Imaging Department Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences Suzhou China; School of Biomedical Engineering (Suzhou) Division of Life Sciences and Medicine University of Science and Technology of China Hefei China Department of Physical Education, Jeonbuk National University, Jeonju 54896, Jeollabuk, Republic of Korea Key Laboratory of Deep Oil and Gas, China University of Petroleum (East China), Qingdao, 266580, PR China Polymer Program, Institute of Materials Science, University of Connecticut, Storrs, Connecticut 06269, United States Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan Hubei Province, China Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Key Laboratory for Research and Development of Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou 571199, China Department of Orthopaedics, Changhai Hospital, The Second Military Medical University, Shanghai 200433, China CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health University of Chinese Academy of Sciences, Chinese Academy of Sciences Shanghai China Department of Orthopedics Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou China Department of General Surgery, Changshu Hospital Affiliated to Soochow University, Changshu, China Department of Critical Care Medicine, the Second Affiliated Hospital of Harbin Medical University, Harbin, China; College of Biotechnology and Pharmaceutical Engineering; Nanjing Tech University; Nanjing; China; National Engineering Technique Research Center for Biotechnology Department of Mechanical and Aerospace Engineering; West Virginia University; Morgantown; USA State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China Southwest University 1 College of Chemistry and Chemical Engineering, , Chongqing 400715, China aDivision of Biology, California Institute of Technology, Pasadena California 91125 1Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario, Canada. School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, China School of Materials Science and Engineering, Sichuan University, Chengdu 610065, P. R. China *Immunology Division and; Medical Biology and Department of Neurology, The First Affiliated Hospital of Dalian Medical University, Liaoning Province, China Zhongshan Hospital Fudan University, Shanghai, China State Key Laboratory Base of Eco-Chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China Department of Respiratory Medicine, Shanghai Tenth People's Hospital, Tongji University, Shanghai 200072, China Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China; State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Dingxi Road 1295, Changning, Shanghai 200050, China Key Unit of Modulating Liver to Treat Hyperlipemia SATCM (State Administration of Traditional Chinese Medicine), Level 3 Lab of Lipid Metabolism SATCM, Guangdong TCM Key Laboratory for Metabolic Diseases, Guangdong Pharmaceutical University, Guangzhou Higher Education Mega Centre, Guangzhou 510006, China Department of Pathology, Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing 400016, P.R. China Shanghai University of Traditional Chinese Medicine, Shanghai, China Center for Proteomics & Bioinformatics Case Western Reserve University Cleveland OH USA Department of Gynecology Obstetrics and Gynecology Hospital of Fudan University Shanghai People's Republic of China Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences 5 , Beijing 100190, China College of Food and Chemical Engineering, Hunan Provincial Key Laboratory of Soybean Products Processing and Safety Control Shaoyang University Shaoyang Hunan China Department of Neurology, The Second Hospital of Jilin University, Changchun, China College of Plant Protection (State & Local Joint Engineering Research Center of Green Pesticide Invention and Application), Nanjing Agricultural University, Nanjing 210095, P.R. China; Ministry of Education, Key Laboratory of Integrated Management of Crop Diseases and Pests (Nanjing Agricultural University), Nanjing, P.R. China State Key Laboratory Base of Eco-Chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science & Technology, Qingdao, 266042, P. R. China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan, China; Chinese Academy of Sciences Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China. Institute of Food and Nutrition, Shandong Center for Disease Control and Prevention, Jinan, Shandong, P. R. China; Shandong Center for Food Safety Risk Assessment, Jinan, Shandong, P. R. China; Academy of Preventive Medicine, Shandong University, Jinan, Shandong, P. R. China Department of Dermatology The Children's Hospital of Fudan University Shanghai China College of Basic Medical Sciences Dalian Medical University Liaoning China Department of General Surgery, Changshu No. 1 People’s Hospital, Changshu, 215500 Jiangsu Province, China Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai, China.; Shanghai Clinical Medical Center of Diabetes, Shanghai Institute for Diabetes, Shanghai Key Laboratory of Diabetes, Shanghai Key Clinical Center of Metabolic Diseases, Shanghai, China. High Magnetic Field Laboratory, Chinese Academy of Sciences, Hefei, Anhui 230031, P.R. China The Department of Hepatology No. 2 People's Hospital of Fuyang City Fuyang Anhui China Department of Dermatology Jim Ayers Institute for Precancer Detection and Diagnosis, Vanderbilt-Ingram Cancer Center, Medical Research Building III, 465 21st Avenue South, Nashville, Tennessee 37232, Department of Cancer Biology, Vanderbilt University School of Medicine, U9207 Medical Research Building III, 465 21st Avenue South, Nashville, Tennessee 37232, Department of Biochemistry, Vanderbilt University School of Medicine, U1213 Medical Research Building III, 465 21st Avenue South, Nashville, Tennessee 37232, Department of... Department of Radiology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, Ohio. Department of Center Laboratory, The Fifth Affiliated Hospital of Guangzhou Medical University, Guangzhou 510700, China Beijing National Laboratory for Condensed Matter Physics and CAS Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China College of Physics Science and Technology, China University of Petroleum Dongying, Shandong 257061, PR China Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai 200233, China. Institute of Crop Protection, Guizhou University, Guiyang 550025, China Department of Endocrinology NHC Key Laboratory of Endocrinology Peking Union Medical College Hospital Chinese Academy of Medical Science Beijing China; Peking Union Medical College Beijing China Liver Transplantation Center Beijing Friendship Hospital Capital Medical University Beijing China; Clinical Center for Pediatric Liver Transplantation Capital Medical University Beijing China; Intensive Care Unit Beijing Friendship Hospital Capital Medical University Beijing China Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai, China State Key Laboratory of Fine Chemicals, School of Pharmaceutical Science and Technology, Dalian University of Technology, Dalian 116024, P. R. China Department of Applied Chemistry, East China Institute of Technology, Fuzhou, Jiangxi Province 344000, P. R. China Yunnan University of Traditional Chinese Medicine, Kunming, Yunnan, People's Republic of China. Key Laboratory for Animal Genetic Diversity and Evolution of High Education in Yunnan Province School of Life Sciences Yunnan University Kunming P.R. China From the Department of Physiology and Pharmacology (A.B., L.V., D.H.K., K.S., N.G.A.), University of Toledo, Toledo, Ohio; Departments of Pharmacology (A.B., M.L., M.C., S.J.P., A.K., N.G.A.) and Medicine (S.J.P.), New York Medical College, Valhalla, NY; Department of Biomedical Sciences and Biotechnology (R.R., L.R.), University of Brescia, Brescia, Italy; Department of Pediatrics and Center for Applied Genomics (P.M.), Charles University, Prague, Czech Republic; Laboratory of Pharmacology, The... Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China; Cardiovascular Research Institute, Wuhan University, Wuhan, Hubei 430060, China; Hubei Key Laboratory of Cardiology, Wuhan, Hubei 430060, China Department of Radiology Affiliated Hospital of the Academy of Military Medical Sciences Beijing China State Key Laboratory of Bioorganic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 354 Fenglin Road, Shanghai 200032, China Department of Clinical Laboratory, Peking Union Medical College Hospital, Chinese Academy of Medical Science , Beijing , China Division of Anti-Tumor Pharmacology Department of Animal Ecology College of Life and environmental Science, Wenzhou University Wenzhou P.R. China Key Laboratory of Green Chemistry and Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610064, P. R. China Heilongjiang Entry-Exit Inspection and Quarantine Bureau, Harbin, Heilongjiang Province, People's Republic of China Department of Pediatric Orthopaedics, Children's Hospital of ChongQing Medical University, Chongqing, China. Department of Urology, The Xinjiang Uygur Autonomous Region People's Hospital, Uygur, China. State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China Ningbo Institute of Material Technology and Engineering; Chinese Academy of Sciences (CAS); Ningbo; China School of Traditional Chinese Medicine, Capital Medical University, Beijing 100069, China The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province Mengchao Hepatobiliary Hospital of Fujian Medical University Fuzhou 350025 P. R. China; The Liver Center of Fujian Province Fujian Medical University Fuzhou 350025 P. R. China Institute of Food and Nutraceutical Science, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China Department of Pathology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China Cancer Immunology Program, Peter MacCallum Cancer Centre Melbourne Victoria Australia Department of Obstetrics and Gynecology The Second People's Hospital of Huai'an Jiangsu China Department of Infectious Diseases, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China Department of Chemistry, Zhejiang University, Hangzhou 310027, P. R. China David R. Cheriton School of Computer Science, University of Waterloo Waterloo, Ontario, Canada. Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei, Collaborative Innovation Center of Vegetable, College of Horticulture, Hebei Agricultural University, Baoding 071001, China Department of Infectious Disease, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. School of Biotechnology, Southern Medical University, Guangzhou, P.R. China. Department of Pharmacy, Lianyungang TCM Hospital Affiliated to Nanjing University of Chinese Medicine , No.160 Chaoyang Middle Road , Haizhou District , Lianyungang 222000 , China Department of Cell and Developmental Biology, School of Biological Sciences, University of California, San Diego, La Jolla, California, USA. Department of Natural Medicine, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China. Department of Pharmacology, New York Medical College, Valhalla, New York. Department of Neurology The First Affiliated Hospital of Bengbu Medical College Bengbu Anhui China Department of Pathology, Fudan University Shanghai Cancer Center, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, P.R. China Section of Cell and Developmental Biology, Division of Biological Sciences, University of California San Diego, La Jolla, CA 92093 Department of Microbiology; Third Military Medical University; Chongqing; China School of Energy and Power Engineering MIIT Key Laboratory of Thermal Control of Electronic Equipment, School of Chemistry and Chemical Engineering Nanjing University of Science and Technology Nanjing 210094 China Department of Vascular Surgery, The 2nd Xiang-ya Hospital, Central South University, Changsha, Hunan 410011, China; Angiopathy Institute, Central South University, Changsha, Hunan 410011, China Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208;; State Key Laboratory of Structural Analysis for Industrial Equipment, Dalian University of Technology, Dalian 116024, China; School of Engineering, Macquarie University, Sydney, New South Wales 2109, Australia College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 210009, China; National Engineering Technique Research Center for Biotechnology, Nanjing 211816, China; Jiangsu National Synergetic Innovation Center for Advanced Materials, Nanjing 210023, China College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, People’s Republic of China Beijing Key Laboratory of Quantum Devices Key Laboratory for Physics and Chemistry of Nanodevices and Department of Electronics Peking University Beijing 100871 China Department of Orthopedics, Sun Yat-sen Memorial Hospital, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China Department of Nephrology, The First Affiliated Hospital; Sun Yat-sen University; Guangzhou Guangdong China; Key Laboratory of Nephrology; Ministry of Health and Guangdong Province; Guangzhou Guangdong China 1 State Key Laboratory of Intelligent Technology & System, Department of Computer Science and Technology, Tsinghua University, Beijing 100084, China, 2Bioinformatics Division, TNLIST and Department of Antomation, Tsinghua University, Beijing 100084, China, 3School of Computer Science, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada, 4CWI, P.O. Box 94079, 1090 GB Amsterdam, The Netherlands and 5Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11274, USA; 1 State Key Laboratory of Intelligent Technology & System, Department of Computer Science and Technology, Tsinghua University, Beijing 100084, China, 2Bioinformatics Division, TNLIST and Department of Antomation, Tsinghua University, Beijing 100084, China, 3School of Computer Science, University of Waterloo, Waterloo, Ontario N2L 3G1, Canada, 4CWI, P.O. Box 94079, 1090 GB Amsterdam, The Netherlands and 5Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11274, USA Department of Thoracic Surgery, Zhongshan Hospital Fudan University Shanghai China; Cancer Center, Zhongshan Hospital Fudan University Shanghai China Key Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100730, China Energy and Catalysis Laboratory Department of Mechanical and Automation Engineering The Chinese University of Hong Kong Shatin, NT Hong Kong SAR China grid.413109.e 0000000097356249 Key Laboratory of Industrial Fermentation Microbiology, Ministry of Education, Tianjin Key Laboratory of Industrial Microbiology, National Engineering Laboratory for Industrial Enzymes, The College of Biotechnology Tianjin University of Science and Technology Tianjin People’s Republic of China College of Science & Ministry-province jointly-constructed Cultivation Base for State Key Laboratory of Processing for Mom-ferrous Metal and Featured Materials & Key Lab. of Nonferrous Materials and New Processing Technology Guilin University of Technology Guilin 541004 China State Key Laboratory of Organ Failure Research, School of Biotechnology, Institute of Antibody Engineering Southern Medical University Guangzhou Guangdong People's Republic of China Key Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, No. 1 Shuaifu Garden, Beijing 100730, China Institute of Antibody Engineering, School of Biotechnology, Southern Medical University, Guangzhou, People's Republic of China. Department of Neurosurgery Zhengzhou University People's Hospital Henan Provincial People's Hospital Zhengzhou China; Juha International Central Laboratory of Neurosurgery Henan Provincial People's Hospital Zhengzhou China Department of Endocrinology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China. Senior Department of Orthopedics National Clinical Research Center for Orthopedics Sports Medicine and Rehabilitation Chinese PLA General Hospital Beijing 100853 China School of Nursing and Rehabilitation, Shandong University, Jinan, Shandong, China Key Lab of Animal Ecology and Conservation Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou, Jiangsu 215123, P.R. China Biotechnology Research Center Shandong Academy of Agricultural Sciences Shandong Provincial Key Laboratory of Crop Genetic Improvement Ecology and Physiology Jinan China Department of Biochemistry, Duke University Medical Center, Research Drive, Durham, NC 27710 Authors' Affiliations: 1Ludwig Institute for Cancer Research, University of California San Diego, La Jolla, California; 2Department of Molecular Virology, Immunology and Medical Genetics, Comprehensive Cancer Center, The Ohio State University, Columbus, Ohio; 3Department of Human and Molecular Genetics, Virginia Commonwealth University School of Medicine, Richmond, Virginia; 4Department of Neurology, Washington University School of Medicine, St. Louis, Missouri; and 5Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center, New York, New York Department of Entomology, University of California, Riverside, Riverside, CA Department of Organ Transplantation and National Key Clinic Specialty, Neurosurgery Institute of Guangdong Province, Department of Neurosurgery (RD), Zhujiang Hospital, Southern Medical University, Guangzhou, People's Republic of China College of Agriculture Northeast Agricultural University Harbin 150030 China Ames Laboratory and Department of Chemistry, Iowa State University, Ames, Iowa 50011 Department of Pediatrics, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma, USA Department of Radiation Oncology, University of Texas MD Anderson Cancer Center, Houston Division of General Internal Medicine and Public Health, Department of Medicine, Vanderbilt University Medical Center, Nashville, Tennessee (JCD, NNC, JFP, NBP); Department of Biomedical Informatics, Vanderbilt University Medical Center, Nashville, Tennessee (JCD, JFP, RAM, LB); Veterans Administration, Tennessee Valley Healthcare System, Tennessee Valley Geriatric Research Education Clinical Center (GRECC), Nashville, Tennessee (NNC, JFP); Department of Biostatistics, Vanderbilt University, Nashville, Tennessee (ML) Medical Imaging Department, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, China Department of Chemistry, University of Guelph, Guelph, Ontario, Canada N1G 2W1 Department of Neurology, Longgang District Central Hospital of ShenZhen, Shenzhen, Guangdong Province, China. National Laboratory for Condensed Matter Physics and Key Laboratory of Soft Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China; Songshan Lake Materials Laboratory, Dongguan, Guangdong 523808, China Key Laboratory of Antibody Engineering of Guangdong Higher Education Institutes School of Laboratory Medicine and Biotechnology Southern Medical University Guangzhou China School of Chemistry and Chemical Engineering; Southwest University; Chongqing, China Department of Molecular and Comparative Pathobiology, Johns Hopkins School of Medicine, Baltimore, Maryland, USA Faculty of Engineering, University of Nottingham, Nottingham NG7 2RD, U.K. Key Laboratory of Animal Models and Human Disease Mechanisms of The Chinese Academy of Sciences and Yunnan Province Kunming Institute of Zoology Kunming China Department of Disease Control, Linqu County Public Health Bureau, Linqu, China Shaanxi Key Laboratory of Condensed Matter Structures and Properties, School of Natural and Applied Science, Northwestern Polytechnical University, Xi’an 710072, China Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing 100193, China. School of Mechanical and Mining Engineering, The University of Queensland, Brisbane, QLD 4072, Australia School of Mechatronics Engineering, Harbin Institute of Technology, Harbin 150001, China First Department of Pathology, Kansai Medical University, Osaka, Japan Department of Microbiology, College of Basic Medical Sciences, Third Military Medical University, Chongqing, China. Key Laboratory of Eco-Chemical Engineering, Ministry of Education, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China Center for Biomedical Materials and Tissue Engineering; Academy for Advanced Interdisciplinary Studies; Peking University; Beijing 100871; People's Republic of China Department of Orthopaedics; Changhai Hospital; Second Military Medical University; Shanghai China From the Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China (Li, Zhou, Lv, Cai, Wan, Lu, Shui, Yang); Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China (Li, Zhou, Lv, Cai, Wan, Lu, Shui, Yang); the Institute of Pathology, Fudan University, Shanghai, China (Li, Zhou, Lv, Cai, Wan, Lu, Shui, Yang) Dermatology Hospital, Southern Medical University , Guangzhou , China Institute of Food Science and Technology, Chinese Academy of Agriculture Sciences/Comprehensive Utilization Laboratory of Cereal and Oil Processing, Ministry of Agriculture and Rural Affairs of the People Republic of China, Beijing 100193, China The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210023, P.R. China From the Department of Pathology, Fudan University Shanghai Cancer Center.; From the Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China.; From the Institute of Pathology, Fudan University, Shanghai, China. The Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA Research Unit of Infection & Immunity, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, 610041, China. Department of Epidemiology and Biostatistics, School of Public Health, Indiana University Bloomington, Bloomington, IN Key Laboratory for Physical Electronics and Devices of the Ministry of Education & Shaanxi Key Lab of Information Photonic Technique; School of Electronics & Information Engineering; Xi'an Jiaotong University; Xi'an; China State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, United States; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, United States Center for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology 1 , and 2; Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802 1 , and 2 School of Electrical and Control Engineering, North China University of Technology, Beijing 100144, China School of Materials Science and Engineering State Key Lab of New Ceramics and Fine Processing Tsinghua UniversityBeijing 100084 China Department of Radiology, Huadong Hospital, Affiliated to Fudan University, Shanghai, China (mainland) Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province Kunming Institute of Zoology Kunming Yunnan China State Key Laboratory of Geological Processes and Mineral Resources, China University of Geosciences, Wuhan 430074, P. R. China State Key Laboratory of Geological Processes and Mineral Resources, China University of Geosciences, Wuhan 430074, P.R. China From the Department of Physiology and Institute for Biomedical Research (Y.L., D.J.A., B.J.M.), and Department of Pathology (F.Y), Basic & Clinical Genomics Laboratory, Department of Medicine (C.W., M.L., M.W.), St George Hospital, The University of Sydney; and The John Curtain School of Medical Research (J.A.W.), Australian National University, Canberra (Australia). Center for Molecular Immunology and Infectious Diseases and Department of Veterinary and Biomedical Sciences, Pennsylvania State University, University Park, PA 16802 Jilin University State Key Laboratory for Superhard Materials, Institute of Atomic and Molecular Physics, , Changchun 130012, People’s Republic of China Department of Laboratory Medicine University of Iowa Carver College of Medicine, Iowa City, Iowa, USA Department of Orthopaedics The 2nd Affiliated Hospital of Harbin Medical University Harbin China Authors' Affiliations: Departments of 1Biochemistry, 2Biomedical Informatics, 3Surgery, 4Cancer Biology, and 5Biostatistics; and 6Jim Ayers Institute for Precancer Detection and Diagnosis, Vanderbilt University School of Medicine, Nashville, Tennessee Department of Chemistry University of Liverpool Crown Street Liverpool L69 7ZD UK Department of Vascular Surgery, The First Affiliated Hospital, School of Medicine, Zhejiang University, China Department of Orthopaedics, First Medical Center, Chinese PLA General Hospital, Beijing, China; National Clinical Research Center for Orthopedics, Sports Medicine & Rehabilitation, Beijing, China School of Computer Science and Technology, Nantong University, Nantong, China College of Animal Science and Technology Henan Agricultural University Zhengzhou China Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Kunming, Yunnan 650223, China Department of Biostatistics, Vanderbilt University School of Medicine, Nashville, TN. State Key Lab of Transducer Technology Shanghai Institute of Microsystem and Information Technology Chinese Academy of Sciences Shanghai 200050 China Department of Chemistry, School of Chemistry and Chemical Engineering Southwest University Chongqing 400715 China Department of Emergency, Zhuzhou Central Hospital, Zhuzhou, Hunan 412000, P.R. China State Key Laboratory of Organ Failure Research Institute of Antibody Engineering School of Biotechnology Southern Medical University Guangzhou P.R. China College of Life Science, Hebei Agricultural University, Baoding, China Changsha Stomatological Hospital; Changsha 410000; P. R. China Norris Comprehensive Cancer Center University of Southern California Los Angeles California USA State Key Laboratory of CAD&CG, Zhejiang University, Hangzhou, China Department of Chemistry and Chemical Biology, Cornell University, Ithaca, United States From the Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, China; Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, China; Institute of Pathology, Fudan University, Shanghai, China Department of Nutrition, Food Hygiene and Toxicology, West China School of Public Health and West China Fourth Hospital, Sichuan University, No.16, 3rd section, South Renmin Road, 610041 Chengdu, Sichuan, China Key Laboratory of Ecology of Rare and Endangered Species and Environmental Protection (Guangxi Normal University); Ministry of Education; Guilin 541004; PR China Hefei National Laboratory for Physical Sciences at the Microscale; University of Science and Technology of China; Hefei, People's Republic of China Department of Orthopaedic Surgery, University of Pennsylvania, School of Medicine, Philadelphia, Pennsylvania, U.S.A. Cell Therapy Center, 323 Hospital of People's Liberation Army, Xi'an 710054, China *Immunology Division and; §The Department of Pathology and Immunology, Monash Medical School, Prahran, Victoria, Australia; and State Key Laboratory of Plant Genomics and Center for Plant Gene Research, Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China Fujian Institute for Drug Control, Fuzhou 350001. Department of Joint Surgery, Hebei Medical University Affiliated Third Hospital, Shijiazhuang, Hebei, China Department of Neurosurgery, Beijing Tiantan Hospital Capital Medical University Beijing China Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Groton, Connecticut 06340 State Key Laboratory of Metal Matrix Composites; Key Laboratory for Thin Film and Microfabrication Technology of the Ministry of Education; School of Material Science and Engineering; Shanghai Jiao Tong University; Shanghai, P. R. China Department of Trace Examination, National Police University of China, Shenyang 110035, P. R. China; Key Laboratory of Impression Evidence Examination and Identification Technology, Ministry of Public Security, Shenyang 110035, P. R. China Institute of Chemical Materials; China Academy of Engineering Physics (CAEP); Mianyang; China Department of Epidemiology and Biostatistics Indiana University at Bloomington Bloomington Indiana United States of America Institute of Antibody Engineering; School of Biotechnology; Southern Medical University; Guangzhou P.R. China Department of Chemistry and Department of Mechanical and Materials Engineering; University of Nebraska-Lincoln; Lincoln; USA; College of Chemical Engineering School of Energy and Power Engineering, Huazhong University of Science and Technology, Wuhan 430074, China Department of Microbiology, College of Basic Medical Sciences, Army Medical University (Third Military Medical University), Key Laboratory of Microbial Engineering under the Educational Committee in Chongqing, Chongqing, China State Key Laboratory of Radiation Medicine and Protection School for Radiological and Interdisciplinary Sciences (RAD-X) and Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Soochow University 215123 Suzhou China Cell Transplantation and Gene Therapy Institute, Changsha, Hunan 410013, P.R. China Institute of Radiation Medicine, Academy of Military Medical Sciences, Beijing 100850, China. Department of Urology, Shengjing Hospital of China Medical University, Shenyang, Liaoning, China Diabetes and Endocrinology Research Center (A.M.N.-A., N.P., M.L., L.C.), Department of Medicine, Department of Pediatrics, Baylor College of Medicine, Houston, Texas 77030 Department of Vascular Surgery, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. Department of Hospital, Shanghai University of Medicine& Health Sciences Affiliated Zhoupu Hospital, Shanghai, China Department of Chemistry, University of Guelph, Guelph, Ontario, Canada N1G 2W1, Department of Physical Chemistry, Fritz-Haber-Institut der Max-Plank-Gesellschaft, Faradayweg 4-6, D-14195 Berlin, Germany, and BioPhysics Department, University of Ulm, D 89069 Ulm, Germany Key Laboratory of Drug Targeting and Drug Delivery System, Ministry of Education and West China School of Pharmacy, Sichuan University, Chengdu, China; Guizhou Center for Disease Control and Prevention, Guiyang, China. Department of Neuro‐Surgical Oncology, National Clinical Research Center for Neurological Diseases Capital Medical University Beijing China; Department of Neurosurgery, Beijing Neurosurgical Institute Capital Medical University Beijing China Key Laboratory of Molecular Target and Clinical Pharmacology and the State Key Laboratory of Respiratory Disease, School of Pharmaceutical Sciences and the Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong 511436, China College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou, Gansu 730070, People’s Republic of China SINOPEC Dalian Research Institute of Petroleum and Petrochemicals Co., Ltd., Dalian 116045, China Department of Radiology, Huadong Hospital Affiliated to Fudan University, Shanghai 200040, P.R. China Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, People's Republic of China Department of Thoracic Surgery, Jiangsu Cancer Hospital Nanjing Medical University Nanjing China Tianjin Agricultural University, China Institute of Antibody Engineering School of Biotechnology Southern Medical University Guangzhou China School of Life Sciences Yunnan University Kunming P. R. China; Key Laboratory for Animal Genetic Diversity and Evolution of High Education in Yunnan Province Yunnan University Kunming P. R. China Department of Respiratory Medicine, Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai 200072 China School of Materials Science and Engineering Central South University Changsha Hunan 410083 China Institute of Iodine Deficiency Disorders, Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University, Harbin 150081, China State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, P.R. China Key Laboratory of Materials Physics, Anhui Key Laboratory of Nanomaterials and Nanotechnology, Institute of Solid State Physics, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, P.R. China; University of Science and Technology of China, Hefei 230026, P.R. China The First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China (mainland) Department of Infectious Disease, Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine, Nanjing, People’s Republic of China School of Mechanical and Electrical Engineering, Central South University, Changsha 410083, China Hubei Collaborative Innovation Center for Advanced Chemical Materials, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules and College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China School of Food Science and Biological Engineering, Jiangsu University, Zhenjiang 212013, China School of Chemistry and Chemical Engineering Southwest University Chongqing 400715 China College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China Orthopedics Department of Joint Surgury the Third Hospital of Hebei Medical University Shijiazhuang China Institute of Geospatial Information, Information Engineering University, 62 Science Avenue, Zhengzhou 450001, China Department of Microbiology, College of Basic Medical Science, Third Military Medical University, Chongqing, People's Republic of China Department of Nephrology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, People’s Republic of China State Key Laboratory of Transient Optics and Photonics; Xi'an Institute of Optics and Precision Mechanics of CAS; Xi'an; China School of Health Sciences, University of South Australia, Australia State Key Laboratory of Radiation Medicine and Protection, Department of Radiobiology, School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, People’s Republic of China; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou 215123, People’s Republic of China Department of Mechanical Engineering and Department of Civil and Environmental Engineering, Northwestern University, Evanston, IL 60208, USA.; State Key Laboratory of Structural Analysis for Industrial Equipment, Dalian University of Technology, Dalian 116024, China. Institute of Prevention and Treatment of Cardiovascular Diseases in Alpine Environment of Plateau, Characteristic Medical Center of the Chinese People’s Armed Police Forces, Tianjin, China (mainland) Eye Hospital and School of Ophthalmology and Optometry, National Clinical Research Center for Ocular Diseases Wenzhou Medical University Wenzhou China Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200011, China College of Food Science; Northeast Agricultural University; Harbin 150036; China David R. Cheriton School of Computer Science, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1, Canada Department of Pathology and Pathophysiology, School of Basic Medicine, Guangdong Pharmaceutical University, Guangzhou, Guangdong 510006, P.R. China State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences & Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China; State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, P.R. China Cell Therapy Center, 323 Hospital of People’s Liberation Army, Xi’an 710054, China Department of Vascular Surgery, the Second Xiangya Hospital, Central South University, Changsha, Hunan, China; The Institute of Vascular Diseases, Central South University, Changsha, Hunan, China School of Mechanical Engineering and Automation, Harbin Institute of Technology, Shenzhen 518055, China Department of Orthopaedic Surgery Third Hospital of Hebei Medical University Shijiazhuang Hebei China College of Data Science, Taiyuan University of Technology, Taiyuan 030024, China State Key Laboratory of Bioreactor Engineering East China University of Science and Technology Shanghai China Key Laboratory of Endocrinology, Translational Medicine Centre, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China Department of Biology, University of Massachusetts Amherst, Amherst, MA 01003 Department of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China;; Division of Endocrinology, The Children’s Hospital of Philadelphia, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA; Key Laboratory of Endocrinology; Translational Medicine Center; Ministry of Health; Department of Endocrinology; Peking Union Medical College Hospital College of Preclinical Medicine, Fujian Medical University, Fuzhou, PR China; Institutes of Reproductive Sciences, Fujian Medical University, Fuzhou, PR China Department of Urology, the Fifth People’s Hospital of Dongguan, Dongguan, Guangdong Province, China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing Wuhan University of Technology Wuhan 430070 P. R. China Department of Obstetrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China. From the Department of Medicine, St George Hospital, University of New South Wales, Sydney, NSW, Australia. Department of Orthopedics, the Sixth People's Hospital, Shanghai Jiaotong University, Shanghai, 200233, P.R. China. Department of Endocrinology, Nanjing Hospital of Traditional Chinese Medicine, Nanjing 210012, China Department of Microbiology, College of Basic Medical Sciences, Third Military Medical University, 30 Gaotanyan Street, Shapingba District, Chongqing 400038, People’s Republic of China Department of Microbiology, Third Military Medical University, Chongqing, China Department of Biochemistry, University of Minnesota Medical School, Minneapolis, Minnesota 55455, and Krannert Institute of Cardiology, Indiana University, Indianapolis, Indiana 46202 State Key Laboratory for Conservation and Utilization of Subtropical Agro-bioresources, South China Agricultural University , Guangzhou 510642, China; Guangdong Provincial Key Laboratory of Protein Function and Regulation in Agricultural Organisms, College of Life Sciences, South China Agricultural University , Guangzhou 510642, China; Guangdong Laboratory for Lingnan Modern Agriculture , Guangzhou 510642, China School of Water Resources and Environmental Science, China University of Geosciences (Beijing), No. 29, Xueyuan Road, Haidian District, Beijing 100083, China Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee 37232, United States REPAIR-Lab, Institute of Pathology, University Medical Centre of the Johannes Gutenberg University, Mainz, Germany. School of Pharmacy, Henan University, Kaifeng, Henan 475004, P.R. China Department of Orthopedic Trauma, Honghui Hospital, Xi'an Jiaotong University, Xi'an, Shaanxi, China. Department of Orthopaedic Surgery, Honghui Hospital, Xi’an Jiaotong University, Shan’xi, China Department of Psychology University of Nebraska‐Lincoln Lincoln NE USA School of Material Science and Engineering, Ocean University of China, 238 Songling Road, Qingdao, Shandong 266100, China Division of Nephrology and Hypertension, Department of Medicine, University of Louisville, Louisville, Kentucky Department of Internal Medicine and Molecular Science, Graduate School of Medicine, Osaka University, Osaka, Japan State Key Laboratory of Bioreactor Engineering East China University of Science and Technology China National Key Laboratory of Crop Biology MOA Key Laboratory of Horticultural Crop Biology and Germplasm Innovation College of Horticulture Science and Engineering Shandong Agricultural University Tai‐An Shandong 271018 China Key Laboratory of Molecular Microbiology and Technology, Ministry of Education, Department of Microbiology, Nankai University, Tianjin 300071, China. PET Centre, Huashan Hospital, Fudan University, Shanghai, China Department of Cardiovascular Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China College of Computer and Control Engineering, Qiqihar University, Qiqihar, China School of Chemistry, Chemical Engineering, Southwest University, Chongqing 400715, China Department of Epidemiology and Biostatistics Indiana University Bloomington Indiana USA Department of General Surgery, Changshu Hospital Affiliated to Soochow University, Changshu 215500, China School of Biosciences and Biopharmaceutics, Guangdong Pharmaceutical University, 510006 Guangzhou, China Institute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China Department of Nephrology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, 510630, PR China State Key Laboratory of Superhard Materials, Jilin University, Changchun 130012, P. R. China, and Key Laboratory of Special Functional Materials, Henan University, Kaifeng 475004, P. R. China Key Laboratory of Luminescence and Real-Time Analytical Chemistry, Ministry of Education, College of Chemistry and Chemical Engineering, Southwest University, Chongqing 400715, China College of Physics Science and Technology Key Laboratory of Animal Ecology and Conservation Biology Institute of Zoology Chinese Academy of Sciences Chaoyang District Beijing China Department of Pathogenic Biology, Suzhou University, Suzhou 215007, China. Department of Microbiology, College of Basic Medical Sciences, Army Medical University, Chongqing, China Department of Dermatology, Xinhua Hospital, Shanghai Jiaotong University School of Medicine Shanghai 200092, China. Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi, China (mainland) Chinese Swine Mutagenesis Consortium Working Group, Chinese Swine Mutagenesis Consortium, Beijing, China; Pearl Laboratory Animal Sci. & Tech. Co. Ltd, Guangzhou, China School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu 610054, P.R. China University of Shanghai for Science and Technology School of Information Science & Technology, East China Normal University, No. 500 Dong-Chuan Road, Shanghai 200241, China The First Affiliated Hospital of Kunming Medical University Kunming China School of Life Science and Technology, Shanghai Jiaotong University, 200030 Shanghai, China, Department of Chemistry, University of Science and Technology of China, 230026 Hefei, China, Department of Chemistry, Chuzhou Normal College, 239012 Chuzhou, China, and Institute of Allergy Research, Wannan Medical College, 241001 Wuhu, China College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing 211816, China Laboratory of Fish and Shellfish Nutrition, School of Marine Sciences, Ningbo University, Ningbo 315211, PR China Department of Pediatrics College of Medicine, University of Arkansas for Medical Sciences Arkansas Children's Hospital Research Institute Little Rock Arkansas Department of Chemical and Biomolecular Engineering; University of Illinois at Urbana-Champaign; Urbana; USA From the Department of Cardiology, Institute of Cardiovascular Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Department of Thoracic Surgery, Shandong Provincial Chest Hospital, Jinan, Shandong 250013, P.R. China State Key Laboratory of Fine Chemicals; School of Chemical Engineering; Dalian University of Technology; Dalian; P. R. China Department of Dermatology, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, Shanghai 200092, P.R. China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China. State Key Laboratory of Fine Chemicals, Department of Pharmaceutical Science, Department of Polymer Science & Materials, School of Chemical Engineering, Dalian University of Technology, Dalian 116024, P. R. China Department of Entomology University of California Riverside CA USA College of Food Science and Engineering Ocean University of China Qingdao 266003 China. Centre for Inflammatory Diseases, Department of Medicine, Monash University , Clayton, Victoria , Australia Authors' Affiliations: 1Division of Allergy, Pulmonary and Critical Care Medicine, Department of Medicine, 2Department of Pathology, 3Mass Spectrometry Research Center, 4Department of Biochemistry, 5Division of Cancer Biostatistics, Department of Biostatistics, 6Division of Hematology and Oncology, Department of Medicine, 7Department of Thoracic Surgery, 8Epidemiology Division, Department of Medicine, 9Department of Cancer Biology, Vanderbilt-Ingram Comprehensive Cancer Center, Vanderbilt University School of Medicine; 10Veterans Affairs Medical Center, Nashville, Tennessee; 11Pulmonary Division, Department of Medicine, Denver Veterans Affairs Medical Center; and 12Department of Pathology, University of Colorado Denver, Denver, Colorado China International Science & Technology Cooperation Base of Food Nutrition/Safety & Medicinal Chemistry, Key Laboratory of Industrial Fermentation Microbiology of Ministry of Education, College of Bioengineering, Tianjin University of Science & Technology, Tianjin 300457, PR China State Key Laboratory of Plant Genomics and Center for Plant Gene Research Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China College of Chemistry and Chemical Engineering, Northwest Normal University, Lanzhou 730070, China Department of Orthopedics PLA General Hospital Beijing China; National Clinical Research Center for Orthopedics Sports Medicine & Rehabilitation Beijing China State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China Department of Population and Public Health Sciences, USC Norris Comprehensive Cancer Center, Los Angeles, CA Department of Thoracic Surgery, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, China-America Institute of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore Department of Plastics Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, China. University of South Australia, Adelaide, South Australia, Australia State Key Laboratory of Materials Processing and Die & Mould Technology School of Materials Science and Engineering Huazhong University of Science and Technology Wuhan 430074 P.R. China Department of Trace Examination National Police University of China Shenyang Liaoning 110035 P. R. China; Key Laboratory of Impression Evidence Examination and Identification Technology Ministry of Public Security Shenyang Liaoning 110035 P. R. China 1 David R. Cheriton School of Computer Science, University of Waterloo, Waterloo, Ont. N2L 3G1, Canada, 2Institute for Computing Technology, Chinese Academy of Sciences, China and 3Toyota Technological Institute at Chicago, IL 60637, USA Department of Pediatric Surgery, Hunan Children’s Hospital, Changsha, People’s Republic of China Department of DermatologyZhongshan Hospital of Fudan University Shanghai China Department of Pharmacy Affiliated Hospital of Guizhou Medical University Guiyang P.R. China; College of Pharmacy Guizhou Medical University Guiyang P.R. China CAS Key Laboratory of Nutrition, Metabolism and Food Safety Shanghai Institute of Nutrition and Health University of Chinese Academy of Sciences Chinese Academy of Sciences Shanghai 200031 China Department of Dermatology, Huashan Hospital, Fudan University, Shanghai 200040, P.R. China Chinese Academy of Sciences State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, University of Chinese Academy of Sciences, 345 Lingling Road, Shanghai 200032, China Department of Physics and Astronomy, University of Nebraska, Lincoln, Nebraska 68588, United States Department of Molecular Genetics, University of Toronto, Toronto, Ontario, Canada Laboratory of Molecular Translational Medicine Centre for Translational Medicine Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University) Ministry of Education West China Second University Hospital Sichuan University Chengdu China Beijing Institute of Radiation Medicine, Beijing 100850, China. State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou, People’s Republic of China Institute of Genetics and Developmental Biology, Chinese Academy of Sciences, Beijing 100101, China. Unit of Research Complex Kansai Medical University Hirakara Osaka Japan Department of Orthopedics, General Hospital of Chinese PLA, Beijing, China Department of Anus and Colon Surgery, The First Affiliated Hospital of Anhui University of Traditional Chinese Medicine, Hefei, China Department of Hepatology, The Fifth People's Hospital of Suzhou, Suzhou 215007, China The Institute of Antibody Engineering, School of Biotechnology, Southern Medical University, Guangzhou 510515, China, Department of Digestive Diseases, the No. 303 Hospital of PLA, Nanning 530021, China, Oncology Center, Zhujiang Hospital, Southern Medical University, Guangzhou 510282, China, and Department of Digestive Diseases, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China Department of Clinical Laboratory Shandong Provincial Hospital Cheeloo College of Medicine Shandong University Jinan China; Department of Clinical Laboratory Shandong Provincial Hospital Affiliated to Shandong First Medical University Jinan China Chinese Academy of Sciences Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, , No. 17 Long-Xin Lu, Kunming, 650201, Yunnan , China Department of Physiology SL‐39 Tulane University New Orleans LA USA Princess Margaret Cancer Centre, University Health Network, University of Toronto, Toronto, Ontario, Canada Key Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, China West China School of Public Health, Sichuan University, Chengdu 610041, China. Princess Margaret Cancer Centre, University Health Network; Toronto ON Canada Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4283 College of Agriculture, Northeast Agricultural University, Harbin, People’s Republic of China; 1Viral Oncology Program, Center for Cancer and Metabolism, SRI International, Menlo Park, California. Department of Biochemical Engineering and Key Laboratory of Systems Bioengineering of the Ministry of Education School of Chemical Engineering and Technology Tianjin University Tianjin 300354 P. R. China MOE Key Laboratory of Cluster Science, Beijing Key Laboratory of Photoelectronic-Electrophotonic Conversion Materials, School of Chemistry and Chemical Engineering, Beijing Institute of Technology, Beijing 102488, P. R. China Department of OrthopedicsGeneral Hospital of Chinese PLABeijingChina MOE International Joint Laboratory of Materials Microstructure; Institute for New Energy Materials and Low Carbon Technologies; School of Material Science and Engineering; Tianjin University of Technology; Tianjin 300384 Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education East China Normal University Shanghai China Tech Institute for Advanced Materials, College of Materials Science and Engineering, Suqian Advanced Materials Industry Technology Innovation Center, Nanjing Tech University, Nanjing 210009, P. R. China Institute of Antibody Engineering, School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, China. School of Basic Medical Sciences, Hebei University, Baoding, Hebei, China College of Animal Science and Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan, P.R. China Key Laboratory of Endocrinology, Translational Medicine Centre, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100730, P.R. China Institute of Environmental Engineering, Ningxia University, Yinchuan 750021, People's Republic of China; Ningxia (China-Arab) Key Laboratory of Resource Assessment and Environmental Regulation in the Arid Region, Ningxia University, Yinchuan 750021, People's Republic of China Institute of Desertification Control, Ningxia Academy of Agriculture and Forestry Sciences, Yinchuan 750002, China. State Key Laboratory of Applied Organic Chemistry; Lanzhou University; Lanzhou 730000; P. R. China State Key Laboratory of Catalyst, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, China, and State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China [email protected] Department of Hematology and Oncology, The First People’s Hospital of Guiyang, No. 97, Boai Road, Nanming, Guiyang, Guizhou 550002, China College of Biotechnology and Pharmaceutical Engineering, Nanjing Tech University, Nanjing, China. Departments of Urology and Vascular Surgery (HZ, HS, LT, WJ, ML), First Affiliated Hospital of Medical College, Zhejiang University, Hangzhou, People's Republic of China State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang, Jiangsu, China; Jiangsu Kanion Parmaceutical Co., Ltd, Lianyungang, Jiangsu, China; The National & Local Joint Engineering Research Center on the Intelligent manufacturing of TCM, Lianyungang, Jiangsu, China Department of Chemistry, University of Liverpool, Crown Street, Liverpool L69 7ZD, United Kingdom Institute of Epidemiology and Health Statistics, School of Public Health, Lanzhou University, Lanzhou, Gansu, China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, 100101, Beijing, PR China South China Agricultural University State Key Laboratory of Silicon Materials School of Materials Science and Engineering Cyrus Tang Center for Sensor Materials and Application Zhejiang University Hangzhou 310027 China School of Psychology, South China Normal University, Guangzhou 510631, China Department of Orthopedic Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China (mainland) Department of Urology, The Fourth Hospital of Hebei Medical University, Shijiazhuang, China Cancer Immunology Program, Peter MacCallum Cancer Centre, East Melbourne, Victoria, Australia. Department of Pediatrics Hainan Maternal and Children’s Medical Center Haikou Hainan China PET Center, Huashan Hospital Fudan University Shanghai China Department of Gastroenterology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, China School of Laboratory Medicine and Biotechnology, Southern Medical University, Guangzhou, Guangdong, China (mainland) Department of Endocrinology, Key Laboratory of Endocrinology, Ministry of Health, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences , Beijing 100730 , China Department of Physics; Temple University; Philadelphia; USA College of Basic Medical Science, Dalian Medical University, Dalian, China Department of Molecular and Comparative Pathobiology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Department of Anesthesiology, West China Hospital of Sichuan University, Sichuan; The Research Units of West China (2018RU012), Chinese Academy of Medical Sciences, Chengdu Department of Gastroenterology, Yantai Affiliated Hospital of Binzhou Medical University, Yantai, Shandong 264003, P.R. China Department of Infectious Diseases Nanjing Drum Tower Hospital Clinical College of Nanjing University of Chinese Medicine Nanjing Jiangsu China State Key Laboratory of Virtual Reality Technology and Systems, Beihang University, Beijing, China Department of Urology, The Fourth Hospital of Hebei Medical University, Shijiazhuang City, Hebei Province, China Department of Neurosurgery Beijing Tiantan Hospital, Capital Medical University Beijing China Department of Respiratory Medicine, Shanghai Tenth People's Hospital Affiliated to Tongji University, China State Key Laboratory Base of Eco-Chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, 53 Zhengzhou Road, Qingdao 266042, P. R. China 1Department of Pharmacology, College of Medicine, University of South Alabama, Mobile, AL 36688 Department of Chemistry, University of Illinois at Chicago, 845 West Taylor Street, Chicago, Illinois 60607-7061 Department of Human Anatomy, Changzhi Medical College, Changzhi, Shangxi 046000, P.R. China School of Chemical Engineering Sichuan University Chengdu Sichuan 610065 P. R. China Department of Nutrition, Food Hygiene and Toxicology, West China School of Public Health and West China Fourth Hospital, and Healthy Food Evaluation Research Center, Sichuan University, No. 16, 3rd section, South Renmin Road, Wuhou District, Chengdu 610041, Sichuan, P.R. China Department of Fruit Trees, College of Horticulture College of Horticulture of Henan Agricultural University Zhengzhou P. R. China Department of Infectious Diseases, Nanjing Drum Tower Hospital, Nanjing University Medical School, Nanjing, People’s Republic of China Department of Orthopedic Surgery, Luoyang Central Hospital Affiliated to Zhengzhou University, Luoyang 471009, China Department of Vascular Surgery, The First Affiliated Hospital of Medical Science Zhejiang University No. 79 Qing Chun Road 310003 HangZhou China Shanghai Institute of Biochemistry, the Chinese Academy of Sciences, Shanghai 200031, China. Neurology and Intracranial Hypertension & Cerebral Venous Disease Center, National Health Commission of China, Xuanwu Hospital, Capital Medical University, Beijing, China; Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing, China Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School David R. Cheriton School of Computer Science, University of Waterloo, Waterloo, Ontario, Canada. Towson University, Towson, MD, USA University of Houston, Department of Electrical and Computer Engineering, 4800 Calhoun Road, Houston, Texas 77204 Max-Planck-Institut für Strahlenchemie, Stiftstrasse 34-36, D-45470 Mülheim an der Ruhr, Germany, and Institut für Anorganische Chemie der Universität Erlangen-Nürnberg, Egerlandstrasse 1, D-91058 Erlangen, Germany National Key Laboratory for Germplasm Innovation & Utilization of Horticultural Crops, Zhengzhou Fruit Research Institute, Chinese Academy of Agricultural Sciences, Zhengzhou 450009, China; Zhongyuan Research Center, Chinese Academy of Agricultural Sciences, Xinxiang 453514, China Medical Imaging Department Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Science Suzhou 215163 China Department of Physics, Rensselaer Polytechnic Institute, Troy, NY 12180, USA *State Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Biology, School of Life Sciences, Xiamen University, Xiamen 361102, China; Department of Endocrinology, Key Laboratory of Endocrinology, National Health and Family Planning Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College (CAMS & PUMC), Beijing, P.R. China *Department of Biological Sciences, Columbia University, New York, NY 10027; and Section of Immunobiology, Howard Hughes Medical Institute, Yale University School of Medicine, New Haven, CT 06520 Princess Margaret Cancer Centre, University Health Network, Toronto, ON, Canada Donald Danforth Plant Science Center, St. Louis, Missouri, USA Department of Geriatrics, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China Guangzhou Institute of Energy Conversion; Chinese Academy of Sciences; Guangzhou 510640; China; CAS Key Laboratory of Renewable Energy Department of Chemistry, Southern Methodist University, Dallas, Texas 75275-0314 Key Laboratory of Coalbed Methane Resources and Reservoir Formation Process, Ministry of Education, School of Resources and Geoscience, China University of Mining and Technology, Xuzhou 221116, China State Key Laboratory of Microbial Resources Institute of Microbiology, Chinese Academy of Sciences Beijing 100101 China Shanghai Municipal Key Laboratory on Diabetes, Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, and Shanghai Municipal Clinical Center on Diabetes, Shanghai Jiaotong University Affiliated Sixth People’s Hospital, Shanghai 200233, China Department of Medicinal Chemistry, ‡Department of Biochemistry, Molecular Biology & Biophysics, and §Masonic Cancer Center, University of Minnesota, 2231 Sixth Street SE, Minneapolis, Minnesota 55455, United States Cell Transplantation and Gene Therapy Institute, The Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P. R. China; School of Stomatology, Hunan University of Chinese Medicine, Changsha, Hunan 410208, P. R. China; Changsha Stomatological Hospital, Changsha, Hunan 410004, P. R. China Department of Cardiovascular Surgery, First Affiliated Hospital of Zhengzhou University, Zhengzhou, P. R.China College of Physical Education and Health, East China Normal University Department of Psychology, University of Nebraska-Lincoln, Lincoln, Nebraska, USA Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling 712100, China Institute of Advanced Electrochemical Energy & School of Materials Science and Engineering Xi'an University of Technology Xi'an 710048 P. R. China Department of Dermatology Xinhua Hospital Shanghai Jiaotong University School of Medicine Shanghai China Key Laboratory for Thin Film and Microfabrication of the Ministry of Education; Department of Micro/Nano Electronics; School of Electronic Information and Electrical Engineering; Shanghai Jiao Tong University; Shanghai 200240 College of Horticulture, Henan Agricultural University, 95 Wenhua Road, Zhengzhou 450002, China Department of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, China Department of Respiratory Medicine Shanghai 10th People's Hospital Affiliated to Tongji University Shanghai China David R. Cheriton School of Computer Science, University of Waterloo, Waterloo, ON, Canada, N2L 3G1, Canada Department of Thoracic Surgery Jiangsu Key Laboratory of Molecular and Translational Cancer Research Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research Nanjing Medical University Affiliated Cancer Hospital Nanjing China Department of Radiology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China College of Horticulture, Hebei Agricultural University, Baoding 071001, China; Hebei Key Laboratory of Vegetable Germplasm Innovation and Utilization, Baoding 071001, China; Collaborative Innovation Center of Vegetable Industry of Hebei Province, Baoding 071001, China Department of Pathology, the Affiliated Suzhou Municipal Hospital of Nanjing Medical University, Suzhou, China; Co-first author Department of Radiotherapy, Beijing Hospital, No. 1 Dongdan Dahua Road, Dongcheng District, Beijing 100730, China College of Science, China University of Petroleum Qingdao, Shandong 266555, P. R. China Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104-4283 School of Traditional Chinese Medicine, Guangdong Pharmaceutical University, Guangzhou 510006, PR China College of Mechanical and Material Engineering, Collaborative Innovation Center for Energy Equipment of Three Gorges Region, Three Gorges University, 8 Daxue Road, Yichang, Hubei 443002, China Chemistry Department, Wayne State University, 5101 Cass Avenue, Detroit, Michigan 48202 Hunan Provincial Key Laboratory for Synthetic Biology of Traditional Chinese Medicine, Hunan University of Medicine, Huaihua, Hunan 418000, P.R. China Department of Biochemistry, Molecular Biology and Biophysics, Institute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA Department of Orthopedics Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou P.R. China Department of Thoracic Surgery, The First Hospital of Hohhot Department of Biostatistics; Vanderbilt University; Nashville TN USA University of Utah Department of Chemistry, , Salt Lake City, Utah 84112, USA School of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, China; Department of Medical Imaging, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, China Department of Neurosurgery, the Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P.R. China College of Chemistry and Molecular Engineering, Zhengzhou University, Henan 450001, China Dept. Computer Science, Univ. of Waterloo, Waterloo, ON, Canada N2L 3G1. [email protected] Department of Blood Transfusion The First Affiliated Hospital of Guangxi Medical University Nanning People's Republic of China Laboratory of Cardiovascular Disease, Novel, Non-Invasive, and Nutritional Therapeutics (CNT), Graduate School of Medicine, Osaka University State Key Laboratory of Structural Analysis for Industrial Equipment Dalian University of Technology Dalian 116024 China College of Science, Xi’an University of Science and Technology, Xi’an 710054, China Department of Oral and Maxillofacial Surgery, 1st Affiliated Hospital of Kunming Medical College, Kunming 650032, China. School of Nursing and Rehabilitation, Cheeloo College of Medicine Shandong University Jinan China The Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States Department of Clinical Laboratory Key Laboratory for Micro and Nano Photonic Structures (Ministry of Education), Department of Optical Science and Engineering, Fudan University, Shanghai 200433, People’s Republic of China Department of Biochemistry and Molecular Biology, University of Massachusetts, Amherst, MA 01003 Department of Thoracic Surgery, Jiangsu Key Laboratory of Molecular and Translational Cancer Research, Jiangsu Cancer Hospital & Jiangsu Institute of Cancer Research, Nanjing 210009, China Department of Chemistry, Zhejiang University, Hangzhou 310027, P.R. China Department of Chemistry, University of Louisville, Louisville, Kentucky 40292, and ‡Steacie Institute for Molecular Science, National Research Council of Canada, Ottawa, Ontario, Canada K1A OR6 State Key Laboratory of Applied Organic Chemistry and College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P.R. China Biogen, Inc, 250 Binney Street, Cambridge, MA 02142, USA Departments of Surgery College of Basic Medical Science, Dalian Medical University, Dalian, Liaoning, China Center for Gene Regulation, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802 1 University of Maryland, College Park, MD, USA State Key Laboratory Base of Eco-Chemical Engineering, College of Chemistry, Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China, and State Key Laboratory, Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, P. R. China The College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou, Henan 450001, P. R. China Department of Gastroenterology, Zhongda Hospital, School of Medicine, Southeast University, 87 Dingjiaqiao Road, Nanjing, 210009, China Tsinghua–Peking Center for Life Sciences, Tsinghua University, Beijing 100190, China; Beijing Frontier Research Center for Biological Structure, Tsinghua University, Beijing 100190, China; McGovern Institute for Brain Research, Tsinghua University, Beijing 100190, China; School of Life Sciences, Tsinghua University, Beijing 100190, China; Ministry of Education Key Laboratory for Protein Science, Tsinghua University, Beijing 100190, China Department of Entomology, University of California, Riverside, CA 92521;; Center for Disease Vector Research, Institute for Integrative Genome Biology, University of California, Riverside, CA 92521 School of Environmental and Chemical Engineering Jiangsu University of Science and Technology Zhenjiang, Jiangsu 212003 P. R. China Yellow Sea Fisheries Research Institute, CAFS; Laboratory for Marine Fisheries Science and Food Production Processes, Pilot National Laboratory for Marine Science and Technology (Qingdao), Qingdao, China; College of Fisheries and Life Science, Shanghai Ocean University, Shanghai, China; Key Laboratory of Sustainable Development of Marine Fisheries, Ministry of Agriculture, Qingdao, China Department of Orthopaedics Children’s Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Chongqing Key Laboratory of Pediatrics, China International Science and Technology Cooperation base of Child Development and Critical Disorders, Chongqing, China 1 Department of Biostatistics, Vanderbilt University, Nashville, Tennessee 37232, 2Department of Biostatistics and Bioinformatics, Emory University, Atlanta, Georgia 30322 and 3Cancer Biostatistics Center, Vanderbilt-Ingram Cancer Center, Nashville, Tennessee 37232, USA. State Key Laboratory of Metal Matrix Composites, School of Material Science and Engineering, Shanghai Jiao Tong University, No. 800 Dongchuan Road Shanghai, 200240 P.R. China Department of Rheumatology and Immunology, Shandong Provincial Hospital Affiliated to Shandong First Medical University (Shandong Provincial Hospital), Jinan, P.R. China Department of Medical Imaging Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences Suzhou China School of Information Science & Technology, East China Normal University, No. 500, Dong-Chuan Road, Shanghai 200241, China; Department of Computer and Information Science, University of Macau, Avenue Padre Tomas Pereira, Taipa 1356, Macau, China School of Mechanical Engineering and Automation Harbin Institute of Technology Shenzhen China Department of Hepatobiliary Surgery The First Affiliated Hospital of Chongqing Medical University Chongqing 400016 China College of Environmental and Chemical Engineering, Heilongjiang University of Science and Technology, Harbin 150022, P. R. China Stem Cell Biology and Therapy Laboratory of the Key Laboratory for Pediatrics Co‐Designated by Chinese Ministry of Education, Department of Pediatric Surgery The Children's Hospital of Chongqing Medical University Chongqing 400014 China; Molecular Oncology Laboratory, Department of Orthopaedic Surgery and Rehabilitation Medicine The University of Chicago Medical Center Chicago IL 60637 The Experimental Center The Second Affiliated Hospital of Soochow University 1055 Sanxiang Rd Suzhou 215004 China School of Life Sciences, Yunnan University, Kunming, P.R. China and Key Laboratory for Animal Genetic Diversity and Evolution of High Education in Yunnan Province Yunnan University Kunming P.R. China Department of Pharmacology, New York Medical College, Valhalla, New York Department of Orthopaedic Surgery The 3rd Hospital of Hebei Medical University Shijiazhuang Hebei China; Key laboratory of biomechanics of Hebei Province Shijiazhuang Hebei China Department of Orthopedics, Scoliosis Research Center, Changhai Hospital, Second Military Medical University, Shanghai; Oil Crops Research Institute, Chinese Academy of Agricultural Science, Key Laboratory of Oil Crop Biology of the Ministry of Agriculture, Key Laboratory of Crop Cultivation and Physiology, Ministry of Agriculture, Wuhan 430062, China Department of Entomology, University of California, Riverside, CA 92521; School of Life Science and Engineering Southwest Jiaotong University Chengdu 610031 China Bengbu Medical University , Bengbu, Anhui Province 233030 , China Department of Nephrology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China.; Key Laboratory of Nephrology, Ministry of Health and Guangdong Province, Guangzhou, Guangdong 510080, China. Department of Respiratory Medicine, Shanghai 10th People’s Hospital, Tongji University School of Medicine, Shanghai 200072, P. R. China Biostatistics Program Department of Pediatrics College of Medicine University of Arkansas for Medical Sciences Little Rock Arkansas Key Laboratory of Marine Medicine, Chinese Ministry of Education, School of Medicine and Pharmacy, Ocean University of China Department of Radiology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China *Cancer Immunology Program, Trescowthick Laboratories, Peter MacCallum Cancer Centre, East Melbourne; Key Laboratory for the Physics and Chemistry of Nanodevices and Department of Electronics, Peking University, Beijing 100871, China State Key Laboratory of Transducer Technology, Aerospace Information Research Institute, Chinese Academy of Sciences, Beijing 100190, PR China; School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 100049, PR China CGN Inspection Technology Co., Ltd. Department of Endocrinology and Metabolism, Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai, China; Department of Dermatology, Mayo Clinic, Rochester, MN, USA. Department of Medicine, Division of Infectious Diseases, Laboratory of Retrovirology Alpert Medical School of Brown University Providence RI 02903 USA Beijing Synchrotron Radiation Facility, Institute of High Energy Physics, CAS 1 , Beijing 100049, People’s Republic of China Beijing Key Laboratory of Quantum Devices Key Laboratory for the Physics and Chemistry of Nanodevices and Department of Electronics Peking University Beijing 100871 China Department of Nephrology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, China Institute of Applied Electronics, China Academy of Engineering Physics 2 , Mianyang 621900, China Department of Psychology, University of Nebraska-Lincoln, Lincoln, NE, USA The Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556 Beijing Jishuitan Hospital, Beijing, P R China Department of Microbiology, College of Basic Medical Sciences, Key Laboratory of Microbial Engineering Under the Educational Committee in Chongqing, Army Medical University , Chongqing , China Department of Respiratory Medicine, Affiliated Futian Hospital, Guangdong Medical College, China Department of Microbiology Third Military Medical University Chongqing 400038 China Department of Radiology, The Drum Tower Hospital, Affiliate Hospital of Nanjing University Medical School, Nanjing 1 Institute for Computing Technology, Chinese Academy of Sciences, Beijing, China, 2Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA, 3Department of Computer Science, University of Western Ontario, London, ON. N6A 5B8, Canada and 4David R. Cheriton School of Computer Science, University of Waterloo, Waterloo, ON. N2L 3G1, Canada State Key Laboratory of Metal Matrix Composites, School of Material Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China National Institutes for Food and Drug Control Beijing 102629 China Department of Orthopaedic Surgery, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi Province, China Department of Entomology, University of California, Riverside, California 92521 Department of Director's office Zhoupu Hospital of Pudong New Area Shanghai China Department of Radiology, Zhuzhou Central Hospital, Zhuzhou Hunan 412007 [email protected]. Department of Center Laboratory The Fifth Affiliated Hospital of Guangzhou Medical University Guangzhou China Division of Nephrology and Hypertension, Department of Medicine, University of Louisville School of Medicine, Louisville, Kentucky 40292, United States Children's Hospital of Chongqing Medical University, Chongqing. Department of Gynecological Oncology Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China; National Clinical Research Center for Obstetrics and Gynecology, Cancer Biology Research Center (Key Laboratory of the Ministry of Education) Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China Department of Bioengineering, University of California, Los Angeles, California 90095, United States; Department of Electrical Engineering, University of California, Los Angeles, California 90095, United States; School of Engineering, Macquarie University, Sydney 2109, Australia Department of Orthopaedics Chinese PLA General Hospital Beijing China Department of Neurobiology, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P. R. China Key Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, China Key Laboratory of Coalbed Methane Resource & Reservoir Formation Process, Ministry of Education, China University of Mining and Technology, Xuzhou 221116, China; School of Resources & Earth Science, China University of Mining & Technology, Xuzhou 221116, China Department of Molecular Genetics, University of Toronto, Toronto, ON, Canada Division of Biological Sciences, Section of Cell and Developmental Biology, University of California, San Diego , La Jolla, CA 92093 , USA Department of Epidemiology and Biostatistics, Indiana University at Bloomington, Indiana 47405; Department of Epidemiology and Biostatistics, Indiana University at Bloomington, Indiana 47405 REPAIR-Lab, Institute of Pathology; University Medical Centre of the Johannes Gutenberg University; Mainz Germany Department of Cell Biology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong 510515, China 1 School of Health Sciences, University of South Australia, Adelaide, Australia Department of Epidemiology and Biostatistics, Indiana University School of Public Health-Bloomington, Bloomington, IN 47405, USA Institute of Life Sciences Jiangsu University Zhenjiang China Department of Gastroenterology, Third Xiangya Hospital of Central South University, Changsha, People’s Republic of China; Hunan Key Laboratory of Nonresolving Inflammation and Cancer, Changsha, People’s Republic of China Department of Anatomy, Weifang Medical University, Weifang, Shandong, China College of Energy, Xiamen University, Xiamen 361005, China State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China Hubei Collaborative Innovation Center for Advanced Chemical Materials, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules and College of Chemistry and Chemical Engineering, Hubei University, Wuhan, 430062, China National Institute of Metrology; 100013 Beijing China Department of Pharmacology (A.B., M.Z., L.W., M.L.), University of South Alabama College of Medicine, Mobile, Alabama 36688 Department of Materials Science and Engineering College of Materials and Energy South China Agricultural University Guangzhou 510642 P. R. China International Joint Agriculture Research Center for Animal Bio-Breeding, Ministry of Agriculture and Rural Affairs/Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University , Yangling 712100 , China Department of Neurosurgery, The People’s Hospital of Zhengzhou University, Zhengzhou, People’s Republic of China Department of Microbiology, College of Basic Medical Science, Third Military Medical University, Chongqing, China Authors' Affiliations: 1Department of Cell Biology, School of Basic Medical Sciences; and 2Institute of Genetic Engineering, Southern Medical University, Guangzhou, China Department of Pediatrics, and Key Laboratory of Aquaculture Disease Control, Ministry of Agriculture, and State Key Laboratory of Freshwater Ecology and Biotechnology, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan 430072, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China University of Nottingham College of Computer and Control Engineering, Qiqihar University, Qiqihar, China; Heilongjiang Provincial Key Laboratory of Resistance Gene Engineering and Protection of Biodiversity in Cold Areas, Qiqihar, China Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD. Division of Biological Sciences, Section of Cell and Developmental Biology University of California, San Diego La Jolla California USA State Key Laboratory of Virology, Wuhan Institute of Virology, Center for Biosafety Mega-Science, Chinese Academy of Sciences (CAS), Wuhan 430071, P. R. China; University of Chinese Academy of Sciences, Beijing 100049, P. R. China Jiangsu Key Laboratory of Environmental Material & Environmental Engineering, College of Environmental Science and Engineering Yangzhou University Yangzhou P. R. China China-America Institute of Neuroscience, Xuanwu Hospital, Capital Medical University, Beijing, China Office building, Rm 309, First Teaching Hospital of Tianjin University of TCM, No. 314, An Shan Xi Road, Nan Kai District, Tianjin 300193, China Henan Polytechnic University 1 College of Physics and Chemistry, , Jiaozuo 454000, China Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, TX 77030, U.S.A.; Diabetes Research Center, Baylor College of Medicine, Houston, TX 77030, U.S.A. Laboratory of Polymer Chemistry, Department of Materials, Swiss Federal Institute of Technology, ETH Zürich, HCI J 541, CH-8093 Zürich, Switzerland Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences , Beijing, China; School of Physics, University of Chinese Academy of Sciences , Beijing, China; Songshan Lake Materials Laboratory , Dongguan, Guangdong, China Chengdu Xinjin Second People’s Hospital, China Department of Urology Shengjing Hospital of China Medical University Shenyang China Department of Biological Sciences, Columbia University, New York, New York 10027 Division of Biostatistics, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202; Division of Biostatistics, Department of Pediatrics, University of Arkansas for Medical Sciences, Little Rock, Arkansas 72202 State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China Institute of Forestry and Grassland Ecology, Ningxia Academy of Agricultural and Forestry Sciences Yinchuan 750002, China. Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education, East China Normal University, Shanghai, China; College of Physical Education and Health, East China Normal University, Shanghai, China Department of Microbiology, Third Military Medical University, Chongqing 630030, PR China; CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China Department of Respiratory Medicine, Shanghai Tenth People’s Hospital, Tongji University, Shanghai, China School of Life Sciences Yunnan University Kunming P.R. China; Key Laboratory for Biochemistry and Molecular Biology of High Education in Yunnan Province Yunnan University Kunming P.R. China; Key Laboratory for Animal Genetic Diversity and Evolution of High Education in Yunnan Province Yunnan University Kunming P.R. China Departments of Pharmacology and Cardiothoracic Surgery Research Program, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, Maryland, USA. [email protected] 1Department of Colorectal Surgery and Center for Evolutionary Chemical Biology, Department of Chemistry, University of Copenhagen, DK-2100 Copenhagen, Denmark Biogen, 250 Binney Street, Cambridge, MA 02142, USA Department of Microbiology, College of Basic Medical SciencesThird Military Medical University 400038 Chongqing China 1Department of Pathology, Harvard Medical School; Department of Hubei Collaborative Innovation Center for Advanced Chemical Materials, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, and College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China School of Information and Electrical Engineering, China University of Mining and Technology, Xuzhou, Jiangsu 221116, China Key Laboratory for Soft Chemistry and Functional Materials, School of Chemistry and Chemical Engineering, School of Energy and Power Engineering, Nanjing University of Science and Technology, Ministry of Education, Nanjing 210094, People’s Republic of China. Key Laboratory of Animal Models and Human Disease Mechanisms of the Chinese Academy of Sciences and Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China; Kunming College of Life Science, University of Chinese Academy of Sciences, Kunming, Yunnan, China; Kunming Institute of Zoology–The Chinese University of Hong Kong (KIZ-CUHK) Joint Laboratory of Bioresources and Molecular Research in Common Diseases, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China; CAS Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai, China Key Laboratory of Materials Physics, Anhui Key Laboratory of Nanomaterials and Nanotechnology, Institute of Solid State Physics, Chinese Academy of Sciences, Hefei 230031, P. R. China Division of Biological Sciences, Section of Cell and Developmental Biology University of California San Diego San Diego California USA Contribution from the Ames Laboratory and Department of Chemistry, Iowa State University, Ames, Iowa 50011 Department of Pathology, Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, China School of Biotechnology; Southern Medical University; Guangzhou People's Republic of China Department of Orthopaedics, Chinese PLA General Hospital , Beijing 100036, China Department of Microecology, School of Basic Medical Science, Dalian Medical University, China Institute of Pathology, University Medical Centre of the Johannes Gutenberg University Mainz Mainz Germany Computational Biology, University of Southern California, Los Angeles, CA, USA. Key Laboratory of Adolescent Health Assessment and Exercise Intervention of Ministry of Education East China Normal University Shanghai China; College of Physical Education and Health East China Normal University Shanghai China Department of Biochemistry and Molecular Biology, Wright State University, Dayton, Ohio 45435 Department of Orthopaedics, Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, Key Laboratory of Pediatrics in Chongqing, Chongqing International Science and Technology Cooperation Center for Child Development and Disorders, Chongqing, China; Alexion Pharmaceuticals Inc. New Haven CT USA Hefei National Laboratory for Physical Sciences at Microscale, University of Science and Technology of China, 96 Jinzhai Road, Hefei, Anhui 230026, P. R. China Department of Hematology, General Hospital of PLA, Beijing 100853, China. Department of Mechanical, Materials and Manufacturing Engineering, University of Nottingham, University Park, Nottingham NG7 2RD, U.K. Department of Biotechnology, Nanfang Medical University, Guangzhou, Guangdong, P.R. China State Key Laboratory of Metal Matrix Composites, School of Material Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, People’s Republic of China State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000, China From the Departments of Pharmacology (S.W., T.S.), Medicine (J.H.), and Pathology (J.R.S.), the Center for Lung Biology (S.W., J.H., T.S.), and the Comprehensive Sickle Cell Center (J.H., B.O.O.), University of South Alabama College of Medicine, Mobile, Ala, and the Department of Pharmacology (J.T.T., M.L.), Tulane University School of Medicine, New Orleans, La. Department of Radiology, Huadong Hospital Affiliated to Fudan University, Shanghai, China Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States Department of Laboratory Diagnostics The First Affiliated Hospital of USTC Division of Life Sciences and Medicine University of Science and Technology of China Hefei Anhui 230001 P. R. China Kunming Children’s Hospital , 288 Qianxing Road, Kunming, Yunnan 650100 , PR China State Key Laboratory of Advanced Technology for Materials Synthesis and Processing, International School of Materials Science and Engineering Wuhan University of Technology Wuhan 430070 P.R. China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China PET Center, Department of Nuclear Medicine, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China Department of Psychology; University of Nebraska-Lincoln; Lincoln NE 68588-0308 USA College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China, and State Key Laboratory of Elemento-organic Chemistry, Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, P. R. China Ming Li, Syed Mohsin Ali, Syeda Umm-a-OmarahGilani, Jing Liu, Yan-Qing Li, Xiu-Li Zuo, Department of Gastroenterology, Qilu Hospital, Shandong University, Jinan 250012, Shandong Province, China. Tsinghua‐Peking Center for Life Sciences Beijing Frontier Research Center for Biological Structure School of Life Sciences and MOE Key Laboratory for Protein Science Tsinghua University Beijing China College of Chemical engineering; North China University of Science and Technology; Tang shan, China; Department of Chemistry and Department Mechanics and Materials Engineering; University of Nebraska-Lincoln Department of Orthopedics, Changhai Hospital, Navy Medical University, Shanghai, People’s Republic of China Department of Anatomy and Embryology, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian 350108, P.R. China Department of Cardiovascular Surgery The First Affiliated Hospital of Medical College of Xi'an Jiaotong University Xi'an China Department of Pediatrics, First Hospital, Peking University, Beijing 100034, China. Departments of Cell and Developmental Biology, Cancer Biology, Biostatistics, and Biochemistry, and The Proteomics Laboratory of the Mass Spectrometry Research Center, Vanderbilt University School of Medicine, Nashville, Tennessee 37232, McKusick-Nathans Institute of Genetic Medicine and the Departments of Biological Chemistry, Oncology and Pathology, Johns Hopkins University, Baltimore, Maryland 21205, Department of Cell Biology, Charles University, Prague, Czech Republic, and Institute of... State Key Laboratory of Information Engineering in Surveying, Mapping and Remote Sensing, Wuhan University, Luoyu Road No. 129, Wuhan 430079, China; Institute of Geodesy and Photogrammetry, ETH Zurich, 8093 Zurich, Switzerland Donald Danforth Plant Science Center, 975 North Warson Road, St. Louis, Missouri 63132 Key Laboratory of Intelligent Information Processing, Institute of Computing Technology, Chinese Academy of Sciences, Beijing, China Department of Pathophysiology Nankai University School of Medicine Tianjin China Department of Endocrinology the Fourth Affiliated Hospital of Harbin Medical University Harbin China Ming Li, Wenjin Zhao, and Fanle Meng, Chinese Academy of Geological Sciences, Baiwanzhuang Road 26, Beijing 100037, China. Institute of Microelectronic Material & Technology, School of Material Science and Engineering, Shanghai Jiao Tong University, Shanghai 200240, China Research Institute of Petroleum Exploration & Development, Beijing 100083, China Institute of Chemical Materials; China Academy of Engineering Physics; Mianyang; China Department of Molecular, Cellular, and Developmental Biology, University of Michigan, Ann Arbor, MI 48109 Department of Neurology and China-America Institute of Neuroscience, Xuanwu Hospital, Beijing Institute of Brain Disorders, Capital Medical University, Beijing, China Department of Dermatology Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai China The Computational Genomics Lab, Department of Epidemiology and Biostatistics, Michigan State University, East Lansing, Michigan. Department of Endocrinology and Metabolism, The Fourth Hospital of Harbin Medical University Harbin 150001, Heilongjiang, People's Republic of China. Department of Radiology, Fudan University Huadong Hospital, Shanghai, People's Republic of China Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, P. R. China; Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, P. R. China Translational Sciences, Biogen Idec Inc., Cambridge, MA, USA Department of Chemistry and Chemical Engineering; Jiangxi Normal University; Nanchang; China Department of Cardiology, The Second Hospital of Jilin University, Changchun, Jilin, China Department of Control Science and Engineering, University of Shanghai for Science and Technology, Shanghai, China The Provincial Special Key Laboratory for Development and Utilization of Insect Resources of Guizhou, Guiyang, China Department of Thoracic Surgery, Zhongshan Hospital, Fudan University, Shanghai, China Department of Orthopaedic Surgery, Ningbo Sixth Hospital, Ningbo, China. Department of Radiology; Affiliated Drum Tower Hospital of Nanjing University Medical School; Nanjing China Changchun Institute of Optics, Fine Mechanics and Physics, Chinese Academy of Sciences, Changchun, Jilin, China; University of Chinese Academy of Sciences, Beijing, China; Medical Imaging Department, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou, Jiangsu, China Tianyou Hospital Affiliated to Wuhan University of Science and Technology, Wuhan, Hubei, P. R. China China Academy of Civil Aviation Science and Technology, Beijing 100028, P. R. China Department of Urology Second Affiliated Hospital of Shantou University Medical College Shantou People's Republic of China Department of Orthopaedic Surgery, Shanghai Changhai Hospital, Shanghai, China Department of Chemistry Sichuan University Chengdu 610064 People's Republic of China Laboratory for AIDS Vaccine Research and Development, Department of Surgery, Duke University Medical Center, Durham, NC; Institute of Nanochemistry and Nanobiology, School of Environmental and Chemical Engineering, Shanghai University, Shanghai 200444, P. R. China. Department of Thoracic Surgery Zhongshan Hospital, Fudan University Shanghai China Department of Radiology The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing China College of Animal Science Inner Mongolia Agricultural University Hohhot China State Key Laboratory of Materials Processing and Die & Mould Technology, School of Materials Science and Engineering, Huazhong University of Science and Technology, Wuhan 430074, P. R. China Department of Radiology, Huadong Hospital Affiliated to Fudan University, Shanghai, China (mainland) Department of Vascular Surgery, The Second Xiangya Hospital of Central South University, Changsha, China; Vascular Disease Institute of Central South University, Changsha, China Key Laboratory of Materials for High Power Laser, Shanghai Institute of Optics and Fine Mechanics, Chinese Academy of Sciences, Shanghai 201800, PR China; Graduate School of Chinese Academy of Science, Beijing 100039, PR China University of Science and Technology of China Department of Rehabilitation Medicine, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China Department of Organ Transplantation, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China Department of Orthopaedics, Changhai Hospital, Second Military Medical University, Shanghai, China (mainland) Biodel Inc, Danbury CT, USA Nanjing University Department of Respiratory Medicine, Shanghai 10th People’s Hospital Tongji University Shanghai China; Institute of Energy Metabolism and Health Tongji University School of Medicine Shanghai China Sansom Institute for Health Research, University of South Australia, Adelaide, SA. Department of Internal Medicine The Eastern Hospital of the First Affiliated Hospital Sun Yat‐sen University Guangzhou China Department of Infectious Diseases, The Affiliated Infectious Diseases Hospital Suzhou Medical College of Soochow University Suzhou China; Department of Hepatology The Fifth People's Hospital of Suzhou Suzhou China Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri, United States State Key Laboratory of Metal Matrix Composites, School of Material Science and Engineering, Shanghai Jiao Tong University, No. 800 Dongchuan Road, Shanghai 200240, People's Republic of China Stem Cell Biology and Therapy Laboratory of the Key Laboratory for Pediatrics designated by Chinese Ministry of Education and Chongqing Bureau of Education Department of Orthopaedic Surgery The Children's Hospital of Chongqing Medical University Chongqing China College of Biotechnology and Pharmaceutical Engineering Nanjing Tech University 30 S Puzhu Rd 211816 Nanjing China University of California at San Francisco, Mount Zion Medical Center, San Francisco, California Institute of Antibody Engineering, School of Laboratory Medicine and Biotechnology Southern Medical University Guangzhou PR China Department of Pharmacy Affiliated Hospital of Guizhou Medical University, Guizhou Medical University Guiyang Guizhou P. R. China Department of Physics, Temple University, Philadelphia, Pennsylvania 19122, United States National Institutes of Health, Center for Interventional Oncology, Radiology and Imaging Sciences, Clinical Center, Bethesda, Maryland, United States Endocrine Key Laboratory of Ministry of Health, Department of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, No. 1 Shuaifuyuan, Wangfujing, Beijing 100730, China College of Chemistry and Chemical Engineering, Xinyang Normal University, Xinyang 464000, China Department of Public Health, School of Medicine, Xi'an Jiaotong University, Xi'an 710061, China. 1University Health Network, Ontario Cancer Institute/Princess Margaret Cancer Centre, Toronto, Ontario, Canada. Department of Thoracic Surgery, Jiangsu Cancer Hospital, Nanjing, People’s Republic of China 1 David R. Cheriton School of Computer Science, University of Waterloo, Ontario, Canada and 2Department of Computer Science, City University of Hong Kong, Kowloon, Hong Kong Department of Physiology, Institute of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, China. The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, China Institute of Chemical Materials, Chinese Academy of Engineering and Physics, 621900 Mianyang, China Department of Hepatobiliary Surgery, General Hospital of Ningxia Medical University, Yinchuan, Ningxia Hui Autonomous Region 750004, P.R. China Key Laboratory of Aquaculture Disease Control Ministry of Agriculture, and State Key Laboratory of Freshwater Ecology and Biotechnology Institute of Hydrobiology Chinese Academy of Sciences Wuhan 430072 China Division of Health Sciences, University of South Australia, Adelaide, SA. College of Animal Science and Technology, Henan Agricultural University, Zhengzhou 450046, China Department of Orthopaedic Surgery, the Third Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, China. School of Light Industry & Chemical Engineering, Dalian Polytechnic University, No. 1 Qinggongyuan, Ganjingzi District, Dalian 116034, P. R. China Department of Mechanical and Aerospace Engineering; West Virginia University; Morgantown, USA Tianjin Key Laboratory of Food Biotechnology, College of Biotechnology & Food Science, Tianjin University of Commerce, Tianjin 300134, China Department of Geriatrics, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China Department of Biochemistry, The University of Iowa, Iowa City, Iowa, USA; Department of Internal Medicine and Epidemiology, The University of Iowa, Iowa City, Iowa, USA; Department of Epidemiology, The University of Iowa, Iowa City, Iowa, USA; Veterans Affairs Health Care System, Iowa City, Iowa, USA State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai200050, China Key Laboratory of Bionic Engineering (Ministry of Education, China), Jilin University, Changchun 130022, China State Key Laboratory of Fine Chemicals; School of Pharmaceutical Science and Technology; Dalian University of Technology; Dalian; P. R. China School of Radiation Medicine and Protection, Medical College of Soochow University, Suzhou 215123, China School of Mechanical and Mining Engineering, Faculty of Engineering, Architecture and Information Technology the University of Queensland Brisbane QLD 4072 Australia University of Waterloo, Canada Department of General Surgery, Changshu Hospital Affiliated to Soochow University, Changshu No.1 People’s Hospital, Changshu, 215500 Jiangsu Province, China Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, 600 Yishan road, Shanghai 200233, China Key Laboratory of Plant Germplasm Enhancement and Specialty Agriculture; Wuhan Botanical Garden, Chinese Academy of Sciences, Moshan, Wuhan 430074; China The College of Chemistry and Molecular Engineering; Zhengzhou University; Zhengzhou 450052, P. R. China Department of Liver Surgery Liver Transplantation Center,West China Hospital of Sichuan University,Chengdu,Sichuan Province,China School of Science and Engineering, Shandong University of Traditional Chinese Medicine Key Laboratory of Chemistry in Ethnic Medicinal Resources, State Ethnic Affairs Commission & Ministry of Education, Yunnan Minzu University, Kunming 650500, Yunnan, China School of Chemistry and Chemical Engineering Southwest University No.2 Tiansheng road Beibei, Chongqing 400715 China Department of Epidemiology, Michigan State University, East Lansing, MI 48824, USA. DaAn Gene Diagnostic Centre, Sun Yat-sen University, Guangzhou, Guangdong Province, People's Republic of China. Department of Spine Surgery, The Third Hospital of Hebei Medical University, Shijiazhuang, Hebei, China (mainland) School of Life Science and Biopharmaceutics Guangdong Pharmaceutical University Guangdong China Department of Thoracic of Zhongshan Hospital Fudan University Shanghai China Key Laboratory of Animal Ecology and Conservation Biology, Institute of Zoology Chinese Academy of Sciences 1 Beichen West Road Chaoyang Beijing 100101 China Department of Intensive Care Medicine, The Second Affiliated Hospital of Harbin Medical University , Harbin , Heilongjiang Province , China Department of Epidemiology and Biostatistics, School of Public Health, Indiana University, Bloomington, IN 47405, USA Key Laboratory of Green Chemistry and Technology (Ministry of Education); College of Chemistry; Sichuan University; Chengdu; China Department of Histology and Embryology, Hunan University of Medicine, Huaihua, Hunan, China. College of Chemistry and Chemical Engineering Northwest Normal University Lanzhou Gansu 730070 P. R. China Department of Otolaryngology, Tinnitus and Hyperacusis Center Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China Key Laboratory of Endocrinology, Ministry of Health, Department of Endocrinology Peking Union Medical College HospitalPeking Union Medical CollegeChinese Academy of Medical Sciences Beijing China Shanghai Institute of Plant Physiology and Ecology Chinese Academy of Sciences Shanghai, 200031 China Taishan scholar advantage and characteristic discipline team of Eco-chemical process and technology College of Chemistry and Molecular Engineering Qingdao University of Science and Technology Qingdao 266042 P. R. China for the EXIT-SEP Investigators Division of AIDS, STD, and TB Laboratory Research, National Center for HIV, STD and TB prevention, Centers for Disease Control and Prevention, Atlanta, Georgia 30333 School of Public Health, Harbin Medical University, Harbin, Heilongjiang 150081, P.R. China Key Laboratory of Luminescence and Real-Time Analytical Chemistry (Southwest University); Ministry of Education; College of Chemistry and Chemical Engineering; Southwest University; Chongqing 400715 1Hormel Institute, University of Minnesota, Austin, Minnesota; 1Department of Endocrinology, NHC Key Laboratory of Endocrinology, Peking Union Medical College Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China Department of Nutrition, Food Hygiene and Toxicology, West China School of Public Health and West China Fourth Hospital, and Healthy Food Evaluation Research Center, Sichuan University, Chengdu, Sichuan, PR China Department of Pathology The Affiliated Suzhou Municipal Hospital of Nanjing Medical University Suzhou China Huangnan Tibetan Autonomous Prefecture Public Security Bureau, Huangnan 811399, Qinghai Province, China. Institute of Chemical Materials, China Academy of Engineering and Physics, Mianyang 621900, China Li Ka Shing Institute of Health Sciences, Departments of Medicine and Therapeutics; Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, Jinan, P.R. China Division of Nephrology, Department of Internal Medicine, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou 510630, China Department of Mechanical and Aerospace Engineering, WVNano Initiative, West Virginia University, Morgantown, West Virginia 26506-6106, Department of Physics, West Virginia University, Morgantown, West Virginia 26506, State Key Laboratory of Silicon Materials, Department of Materials Science & Engineering, Zhejiang University, Hangzhou 310027, P.R. China, and National Energy Technology Laboratory, U.S. Department of Energy, Morgantown, West Virginia 26507 Department of Urology, Fuyang People's Hospital, Fuyang, China [email protected]. Department of Urology Surgery The Second Affiliated Hospital of Jiaxing University Zhejiang China Institute of Food and Nutraceutical Science School of Agriculture and Biology Shanghai Jiao Tong University Shanghai China National Institutes for Food and Drug Control Donald Danforth Plant Science Center, St Louis, MO, USA Department of Clinical Laboratory, Affiliated Provincial Hospital of Anhui Medical University, Hefei, Anhui 230001, P.R. China Key Laboratory of Songliao Aquatic Environment, Ministry of Education, Jilin Jianzhu University, Changchun 130118, China State Key Laboratory of New‐Tech for Chinese Medicine Pharmaceutic Process Jiangsu Kanion Pharmaceutical Co., Ltd. Lianyungang China National Clinical Research Center for Obstetrics and Gynecology, Cancer Biology Research Center (Key Laboratory of the Ministry of Education), Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China; Department of Gynecology and Obstetrics, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Infectious Diseases The First Affiliated Hospital of Nanchang University Nanchang Jiangxi Province P.R. China Key Laboratory of Materials Physics and Anhui Key Laboratory of Nanomaterials and Nanostructures Institute of Solid State Physics Chinese Academy of Sciences Hefei 230031 P.R. China Laboratory of Innovative Medicine, Hong Kong Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules. College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, P.R. China Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Translation Medicine Centre, Peking Union Medical College Hospital, Peking Union Medical College, Chinese Academy of Medical Sciences (PUMCH, CAMS & PUMC), Beijing, China Department of Neurobiology, School of Basic Medicine, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Department of Medical Imaging Suzhou Institute of Biomedical Engineering and Technology Chinese Academy of Sciences Suzhou 215163 China Department of Orthopaedic Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China Department of Orthopaedics General Hospital of Chinese PLA Beijing China Department of Orthopedics Changhai Hospital of Shanghai Shanghai China College of Animal Science and Veterinary Medicine Henan Agricultural University Zhengzhou China Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, People’s Republic of China, Department of Biology and Chemistry, City University Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong SAR, People’s Republic of China, Environmental Measurement Group, National Institute of Advanced Industrial Science and Technology, Onogawa 16-1, Tsukuba, Ibaraki 305-8569, Japan, and Siberia Tiger Park Heilongjiang, Harbin, 88 Songbei Road, 150028, People’s Republic of China Department of Biochemistry, The Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, PRC College of Animal Science and Veterinary Medicine, Heilongjiang Bayi Agricultural University, Daqing 163319, Heilongjiang, China School of Life Sciences and Key Laboratory for Animal Genetic Diversity and Evolution of High Education in Yunnan Province Yunnan University Kunming P. R. China Ningbo University Department of Physics, , Ningbo 315211, China Collaborative Innovation Center for Advanced Organic Chemical Materials Co-constructed by the Province and Ministry, Ministry of Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, P. R. China CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, China (X.L., M.L., Y.O., F.L., L.W., X.W., J.L., M.X., X.Z., H.L., H.Z.). Department of Anesthesiology, Laboratory of Anesthesia and Critical Care Medicine, Translational Neuroscience Center, West China Hospital, Sichuan University and The Research Units of West China, Chinese Academy of Medical Sciences, Chengdu, Sichuan, China China International Science and Technology Cooperation Base of Food Nutrition/Safety and Medicinal Chemistry; Key Laboratory of Industrial Microbiology of Ministry of Education; Tianjin Key Laboratory of Industry Microbiology; College of Biotechnology; Tianjin University of Science & Technology Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, USA Key Laboratory of Quantum Information, CAS, University of Science and Technology of China, Hefei, 230026, China; Synergetic Innovation Center of Quantum Information and Quantum Physics, University of Science and Technology of China, Hefei, Anhui 230026, China Logistical Engineering University Department of Information Engineering, , Chongqing 401311, China Case Western Reserve University, Cleveland, OH Department of Mechanical and Aerospace Engineering, West Virginia University, Morgantown, West Virginia 26506-6106, United States Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China Department of Hematology, the First Hospital of Lanzhou University, Lanzhou 730000, P.R. China Center for Reproductive Medicine, Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing 100191, China; National Clinical Research Center for Obstetrics and Gynecology, Beijing 100191, China; Key Laboratory of Assisted Reproduction, Ministry of Education, Beijing 100191, China; Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproduction, Beijing 100191, China School of Agriculture Engineering and Food Science, Shandong University of Technology, No. 12 Zhangzhou Road, Zibo 255049, China; Hunan Agricultural Equipment Research Institute, Hunan Academy of Agricultural Sciences, No. 120 Donghu Road, Changsha 410125, China; Shandong Provincial Engineering Research Center of Vegetable Safety and Quality Traceability, No. 12 Zhangzhou Road, Zibo 255049, China Department of Chemistry Center for Evolutionary Chemical Biology University of Copenhagen Universitetsparken 5 2100 Copenhagen Denmark School of Biotechnology, Southern Medical University, Guangzhou 510515, China Institute of Crop Protection, Guizhou University, Guiyang 550025, Guizhou P. R. China; College of Agriculture, Guizhou University, Guiyang 550025, Guizhou P. R. China; Provincial Key Laboratory for Agricultural Pest Management in Mountainous Region, Guizhou University, Guiyang 550025, Guizhou P. R. China Department of Pulmonary and Critical Care Medicine, The Eighth Affiliated Hospital, Sun Yat-sen University, Shenzhen, Guangdong, P.R. China State Key Laboratory of Microbial Resources Institute of Microbiology, Chinese Academy of Sciences Beijing China Key Laboratory of Animal Genetics, Breeding and Reproduction of Shaanxi Province, College of Animal Science and Technology, Northwest A&F University, Yangling, China College of Chemistry and Molecular Engineering; Qingdao University of Science and Technology; Qingdao 266042, China Institute of Animal Sciences, Chinese Academy of Agricultural Sciences, Beijing, China Department of Physical Education, Jeonbuk National University, Jeonju 54896, Republic of Korea Department of Pediatrics, Peking University First Hospital, Beijing 100034, China 1Department of General Surgery, Second Affiliated Hospital of Nanchang University, Nanchang, China.; 2Jiangxi Province Key Laboratory of Molecular Medicine, Nanchang, China.; 3Jiangxi Province Engineering Research Center of Hepatobiliary Disease, Nanchang, China. Department of Dermatology, Wuxi Second Affiliated Hospital of Nanjing Medical University, Wuxi, Jiangsu, 214002 People's Republic of China. 1Department of Neurosurgery, Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts. School of Materials Science and Engineering Nanyang Technological University 50 Nanyang Avenue Singapore 639798 Singapore Department of Human Anatomy, School of Basic Medical Sciences Zhengzhou University Zhengzhou People's Republic of China Guangdong Provincial Institute of Dermatology, Guangzhou, Guangdong Department of Neurosurgery Zhengzhou University People's Hospital, Henan Provincial People's Hospital Zhengzhou China; Juha International Central Laboratory of Neurosurgery Henan Provincial People's Hospital Zhengzhou China Department of Thoracic Surgery Zhongshan Hospital Fudan University Shanghai China |
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