http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_4cb7376ae1003fdf410b78f32d4f7c21
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family-name | J. Hunter Hunter |
name | David J. Hunter David J Hunter |
given-name | David J David David J. |
organization-name | Mingfeng Zhang, Abrar A. Qureshi, Lindsay Frazier, David J. Hunter, Jiali Han, Brigham and Women's Hospital and Harvard Medical School; Alan C. Geller, David J. Hunter, Jiali Han, Harvard School of Public Health; Lindsay Frazier, Dana Farber Cancer Institute of Harvard Medical School, Boston, MA; and Mingfeng Zhang, Cancer Center, Nanjing Medical University, Nanjing, China. Authors' Affiliations: Departments of 1Oncology and 2Public Health and Primary Care, Strangeways Research Laboratory, University of Cambridge; 3Eastern Cancer Registration and Information Centre, Unit C-Magog Court, Cambridge, United Kingdom; 4Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland; and 5Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Australia. Royal North Shore Hospital and Institute of Bone and Joint Research Kolling Institute University of Sydney Sydney New South Wales Australia From the Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom. Faculty of Medicine and Health, Institute of Bone and Joint Research, The Kolling Institute, Northern Clinical School, The University of Sydney, Sydney, NSW, Australia; Department of Rheumatology, Royal North Shore Hospital, St Leonards, NSW, Australia New England Baptist Hospital, Boston, MA; Institute of Bone and Joint Research, Kolling Institute, University of Sydney and Rheumatology Department, Royal North Shore Hospital, Sydney, NSW, Australia. 1Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and; 2Department of Epidemiology and; 3Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts Rheumatology Department, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute University of Sydney Sydney NSW Australia Institute of Bone and Joint Research Kolling Institute Sydney Medical School University of Sydney Sydney New South Wales Australia; Rheumatology Department Royal North Shore Hospital Sydney New South Wales Australia University of Sydney and Royal North Shore Hospital Sydney Australia Department of Medicine (J.M., D.J.H., M.S.), Channing Laboratory, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts; Division of Research, New England Baptist Hospital, Boston, MA 1Channing Laboratory, Department of Medicine, Brigham and Women's Hospital;; 3Epidemiology and Kolling Institute of Medical Research, Sydney Musculoskeletal Health, Faculty of Medicine and Health University of Sydney Sydney NSW Australia; Department of Rheumatology Royal North Shore Hospital St Leonards NSW Australia Royal North Shore Hospital, Institute of Bone and Joint Research, Kolling Institute of Medical Research, and University of Sydney St. Leonards New South Wales Australia 7Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts. 1Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; Departments of; 2Nutrition and; 3Epidemiology and 1Department of Epidemiology,; 2Program in Molecular and Genetic Epidemiology, and; 3Department of Nutrition, Harvard School of Public Health,; 4Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts Harvard T.H. Chan School of Public Health, Boston, MA; University of Oxford, Oxford, United Kingdom 2Program in Molecular and Genetic Epidemiology,; 3Department of Epidemiology, Harvard School of Public Health, Boston Massachusettes; Faculty of Medicine and Health, University of Sydney, Kolling Institute of Medical Research, Institute of Bone and Joint Research, Australia;; Department of Rheumatology, Royal North Shore Hospital, Australia; From the Center for Arrhythmia Prevention, Division of Preventive Medicine and Cardiovascular Division (C.M.A.) and Channing Laboratory (E.B.R., D.J.H.), Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Mass; Cardiovascular Research Center (E.G.N., C.A.M., P.T.E.) and Cardiology Division (C.A.M., P.T.E.), Massachusetts General Hospital, Boston, Mass; Department of Epidemiology, Harvard School of Public Health, Boston, Mass (D.J.H., E.B.R.); and Cardiovascular... Authors' Affiliations: 1Program in Molecular and Genetic Epidemiology, Department of 2Epidemiology, 3Nutrition, and 4Biostatistics, Harvard School of Public Health, 5Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; 6Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; 7Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden; 8Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina; 9Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; and 10Division of Epidemiology, NYU Langone Medical Center, New York, New York; Authors' Affiliations: 1Program in Molecular and Genetic Epidemiology, Department of 2Epidemiology, 3Nutrition, and 4Biostatistics, Harvard School of Public Health, 5Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; 6Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; 7Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden; 8Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina; 9Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; and 10Division of Epidemiology, NYU Langone Medical Center, New York, New York; Authors' Affiliations: 1Program in Molecular and Genetic Epidemiology, Department of 2Epidemiology, 3Nutrition, and 4Biostatistics, Harvard School of Public Health, 5Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; 6Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; 7Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden; 8Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina; 9Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; and 10Division of Epidemiology, NYU Langone Medical Center, New York, New York; Authors' Affiliations: 1Program in Molecular and Genetic Epidemiology, Department of 2Epidemiology, 3Nutrition, and 4Biostatistics, Harvard School of Public Health, 5Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; 6Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; 7Department of Surgical and Perioperative Sciences, Urology and Andrology, Umeå University, Umeå, Sweden; 8Center for Human Genomics, Wake Forest University School of Medicine, Winston-Salem, North Carolina; 9Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; and 10Division of Epidemiology, NYU Langone Medical Center, New York, New York Sydney Musculoskeletal Health Kolling Institute of Medical Research, The University of Sydney Sydney New South Wales Australia Authors' Affiliations: 1Epidemiology Research Program, American Cancer Society, Atlanta, Georgia; 2Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; 3Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health; and 4Department of Medicine, Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; Authors' Affiliations: 1Epidemiology Research Program, American Cancer Society, Atlanta, Georgia; 2Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; 3Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health; and 4Department of Medicine, Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts Rheumatology Department, Royal North Shore Hospital, Northern Clinical School, Faculty of Medicine and Health, University of Sydney and Institute of Bone and Joint Research, Kolling Institute of Medical Research, University of Sydney, Sydney, NSW 2065, Australia; Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China. Electronic address: [email protected]. Department of Rheumatology, Royal North Shore Hospital , Sydney, Australia; Institute of Bone and Joint Research, University of Sydney , Sydney, Australia From University of Melbourne and Monash University, Melbourne, Australia, and University of Sydney, Sydney, Australia. From the Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom (D.J.H.). 1Nutrition, Departments of; 2Epidemiology, and; 4Channing Laboratory and Department of Medicine, and Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts; Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women’s Hospital, Boston, Massachusetts; Harvard School of Public Health, Center for Cancer Prevention, Boston, Massachusetts Department of Epidemiology and Harvard Center for Cancer Prevention, Harvard School of Public Health, 02115, Boston, MA, USA;Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, 02115, Boston, MA, USA Department of Rheumatology, Royal North Shore Hospital, Institute of Bone and Joint Research, Kolling Institute University of Sydney Sydney New South Wales Australia Muhimbili University College of Health Sciences, University of Dar-es-Salaam Institute of Bone and Joint Research, Kolling Institute of Medical Research, The University of Sydney, Sydney, New South Wales, Australia; Northern Clinical School, Department of Rheumatology, Royal North Shore Hospital, Faculty of Medicine and Health, The University of Sydney, Sydney, New South Wales, Australia Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts; Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts; Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts Department of Mathematics and Computer Science, Westmont College Santa Barbara CA 93108 Lecturer in Nursing and Health Care, University of Glasgow Nuffield Department of Population Health, University of Oxford Big Data Institute, Old Road Campus, Headington, Oxford, OX3 7LF, UK; Department of Epidemiology, Harvard TH Chan School of Public Health, 677 Huntington Avenue, Boston, MA 02115, USA 1Channing Laboratory, and; 3Departments of Epidemiology,; 4Nutrition, and Nuffield Department of Population Health, University of Oxford, Oxford, UK; Harvard T.H. Chan School of Public Health, Boston, MA, USA Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; 2Channing Laboratory and 3Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Departments of 4Epidemiology, 5Biostatistics, and 6Nutrition, Harvard School of Public Health; 7Department of Ambulatory Care and Prevention, Harvard Medical School; 8Physicians' Health Study, Divisions of Aging, Cardiovascular Medicine, and Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; and Massachusetts Veterans Epidemiology Research and Information Center, Veterans Affairs Boston Healthcare System, Boston, Massachusetts; 9Department of Laboratory Medicine/Pathology, School of Medicine, University of Minnesota, Minneapolis, Minnesota; 10Prevention and Research Center, Mercy Medical Center, Baltimore, Maryland; 11National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands, and Department o; Authors' Affiliations: 1Department of Medical Oncology, Dana-Farber Cancer Institute; 2Channing Laboratory and 3Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Departments of 4Epidemiology, 5Biostatistics, and 6Nutrition, Harvard School of Public Health; 7Department of Ambulatory Care and Prevention, Harvard Medical School; 8Physicians' Health Study, Divisions of Aging, Cardiovascular Medicine, and Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; and Massachusetts Veterans Epidemiology Research and Information Center, Veterans Affairs Boston Healthcare System, Boston, Massachusetts; 9Department of Laboratory Medicine/Pathology, School of Medicine, University of Minnesota, Minneapolis, Minnesota; 10Prevention and Research Center, Mercy Medical Center, Baltimore, Maryland; 11National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands, and Department o Institute of Bone and Joint Research, Kolling Institute, Sydney Medical School, The University of Sydney, Sydney, Australia. Department of Rheumatology, Royal North Shore Hospital, Sydney, Australia. From the Nuffield Department of Population Health (D.J.H.) and the Department of Statistics and Nuffield Department of Medicine (C.H.), University of Oxford, Oxford, and the Alan Turing Institute, London (C.H.) — both in the United Kingdom. 1Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School;; 2Department of Nutrition and; 3Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts Program in Molecular and Genetic Epidemiology (C.H., D.J.H.), Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 02115 2Nutrition,; 3Epidemiology, and; 5Channing Laboratory and Department of Medicine and From the Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom; and the Harvard T.H. Chan School of Public Health, Boston. The Lancet Regional Health Elsevier Sydney Australia The University of Sydney Sydney New South Wales Australia Channing Laboratory, Department of Medicine, Brigham and Womens Hospital and Harvard Medical school, Boston, MA, USA,; Department of Epidemiology, Harvard school of public health, Boston, MA, USA, Authors' Affiliations: 1Clinical Research Program, Department of Dermatology; 2Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Departments of 3Nutrition, 4Epidemiology, and the Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts; 5Department of Epidemiology, Richard M. Fairbanks School of Public Health, Simon Cancer Center, Indiana University, Indianapolis, Indiana; and 6Department of Epidemiology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China; Authors' Affiliations: 1Clinical Research Program, Department of Dermatology; 2Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Departments of 3Nutrition, 4Epidemiology, and the Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts; 5Department of Epidemiology, Richard M. Fairbanks School of Public Health, Simon Cancer Center, Indiana University, Indianapolis, Indiana; and 6Department of Epidemiology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China; Authors' Affiliations: 1Clinical Research Program, Department of Dermatology; 2Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Departments of 3Nutrition, 4Epidemiology, and the Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts; 5Department of Epidemiology, Richard M. Fairbanks School of Public Health, Simon Cancer Center, Indiana University, Indianapolis, Indiana; and 6Department of Epidemiology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China Boston University School of Medicine, Boston, Massachusetts, USA (M.Y., D.J.H.) 1Program in Molecular and Genetic Epidemiology, Harvard School of Public Health,; 2Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and; 3Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts Authors' Affiliations: 1Clinical Research Program, Department of Dermatology and 2Channing Laboratory, Department of Medicine and 3Division of Preventive Medicine, Brigham and Women's Hospital, and Harvard Medical School; 4Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts; 5Broad Institute of Harvard and MIT; and 6FAS Research Computing, Harvard University, Cambridge, Massachusetts; Authors' Affiliations: 1Clinical Research Program, Department of Dermatology and 2Channing Laboratory, Department of Medicine and 3Division of Preventive Medicine, Brigham and Women's Hospital, and Harvard Medical School; 4Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts; 5Broad Institute of Harvard and MIT; and 6FAS Research Computing, Harvard University, Cambridge, Massachusetts; Authors' Affiliations: 1Clinical Research Program, Department of Dermatology and 2Channing Laboratory, Department of Medicine and 3Division of Preventive Medicine, Brigham and Women's Hospital, and Harvard Medical School; 4Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts; 5Broad Institute of Harvard and MIT; and 6FAS Research Computing, Harvard University, Cambridge, Massachusetts 1Department of Epidemiology,; 2Program in Molecular and Genetic Epidemiology, Harvard School of Public Health; and; 3Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA,; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA, Authors' Affiliations: 1Division of Cancer Control and Population Sciences, 2Division of Cancer Epidemiology and Genetics, and 3Division of Cancer Prevention, National Cancer Institute, and 4Division of Cardiovascular Sciences, National Heart, Lung and Blood Institute, NIH, Bethesda, Maryland; 5Office of Public Health Genomics, Centers for Disease Control and Prevention, Atlanta, Georgia; 6Stanford Prevention Research Center, Department of Medicine, Department of Health Research and Policy, Stanford University School of Medicine, and Department of Statistics, Stanford University School of Humanities and Sciences, Stanford, California; 7Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas; 8Division of Medicine, Brigham and Women's Hospital; 9Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School; 10Department of Epidemiology and Nutrition, Harvard School of Public Health; 11Slone Epidemiology Center, Boston University, Boston, Massachusetts; 12Center for Healt 1Departments of Nutrition and; 2Epidemiology and; 3Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, Massachusetts, and; 4Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, Massachusetts From the Nuffield Department of Population Health, University of Oxford, Oxford, UK; and the Harvard T.H. Chan School of Public Health, Boston. Sydney Musculoskeletal Health, Kolling Institute of Medical Research, The University of Sydney, Sydney, Australia; and Department of Rheumatology, Royal North Shore Hospital, St Leonards, Australia Rheumatology Department, Royal North Shore Hospital and Northern Clinical School, University of Sydney, NSW, Australia Rheumatology Department Royal North Shore Hospital Sydney New South Wales Australia; School of Medicine University of Sydney Sydney New South Wales Australia; Institute of Bone and Joint Research Kolling Institute of Medical Research University of Sydney Sydney New South Wales Australia From Department of Nutrition (M.H., M.C.C., R.M.v.D., Q.S., F.B.H., L.Q.) and Program in Molecular and Genetic Epidemiology, Department of Epidemiology (P.K., R.M.v.D., D.J.H., F.B.H.), Harvard School of Public Health, Boston, Mass; Institute of Occupational Medicine (M.H.) and Department of Cardiology, Union Hospital (M.H.), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Department of Biostatistics, University of Washington, Seattle, Wash (C.C.L.);... Institute of Health & Society, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne, UK 4Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School;; 6Departments of Epidemiology and Nutrition, Harvard School of Public Health, Boston, Massachusetts; Rheumatology Department, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Australia. [email protected]. Authors' Affiliations: 1Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland; 2Division of Genetics and Epidemiology, Institute of Cancer Research, London, United Kingdom; 3Epidemiology Research Program, American Cancer Society, Atlanta, Georgia; 4Spanish National Cancer Research Centre; 5Ramón y Cajal University Hospital, Madrid, Spain; 6Channing Laboratory, Department of Medicine, Brigham and Women's Hospital; 7Department of Epidemiology, Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts; 8Centre for Research in Environmental Epidemiology (CREAL); 9CIBER Epidemiología y Salud Pública (CIBERESP); 10Universitat Pompeu Fabra; 11Hospital del Mar-Institut Municipal d'Investigació Mèdica (IMIM), Universitat Pompeu Fabra, Barcelona, Spain; 12National School of Public Health, Athens, Greece; 13Core Genotype Facility, SAIC-Frederick, Inc., National Cancer Institute-Frederick, Frederick, Maryland; 14Universidad de Oviedo, Ovie Nuffield Department of Population Health, University of Oxford, Oxford, UK. Department of Epidemiology, Harvard School of Public Health, 2Channing Laboratory, Department of Medicine, Harvard Medical School and Brigham and Women's Hospital, 3Harvard Center for Cancer Prevention, Boston, Massachusetts 02115; From the Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom, and the Harvard T.H. Chan School of Public Health, Boston (D.J.H.); the Centre for the Aids Programme of Research in South Africa, Durban, and the Department of Epidemiology, Columbia Mailman School of Public Health, New York (S.A.K.); and the Wellcome Trust, London (J.J.F.) Department of Epidemiology Harvard T. H. Chan School of Public Health Boston Massachusetts; Division of Public Health Sciences Fred Hutchinson Cancer Research Center Seattle Washington; Program in Genetic Epidemiology and Statistical Genetics Harvard T.H. Chan School of Public Health Boston Massachusetts Department of Epidemiology Harvard T.H. Chan School of Public Health Boston Massachusetts USA; Nuffield Department of Population Health University of Oxford Oxford United Kingdom D.J. Hunter, PhD, Institute of Bone and Joint Research, Kolling Institute, The University of Sydney, and Department of Rheumatology, Royal North Shore Hospital, St Leonards, Sydney, New South Wales, Australia. Harvard T. H. Chan School of Public Health, Boston, Massachusetts Authors' Affiliations: 1Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics and 2Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland; 3Core Genotyping Facility, Advanced Technology Program, Science Applications International Corporation-Frederick Inc., National Cancer Institute-Frederick, Frederick, Maryland; 4Bioinformed Consulting Services, Gaithersburg, Maryland; 5Department of Environmental Medicine, NYU School of Medicine, New York, New York; 6Program in Molecular and Genetic Epidemiology, Department of Epidemiology and 7Department of Nutrition, Harvard School of Public Health; 8Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; 9Department of Epidemiology, American Cancer Society, Atlanta, Georgia; 10Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland; 11Centre de Recherche pour les Patholog; Authors' Affiliations: 1Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics and 2Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland; 3Core Genotyping Facility, Advanced Technology Program, Science Applications International Corporation-Frederick Inc., National Cancer Institute-Frederick, Frederick, Maryland; 4Bioinformed Consulting Services, Gaithersburg, Maryland; 5Department of Environmental Medicine, NYU School of Medicine, New York, New York; 6Program in Molecular and Genetic Epidemiology, Department of Epidemiology and 7Department of Nutrition, Harvard School of Public Health; 8Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; 9Department of Epidemiology, American Cancer Society, Atlanta, Georgia; 10Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland; 11Centre de Recherche pour les Patholog; Authors' Affiliations: 1Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics and 2Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland; 3Core Genotyping Facility, Advanced Technology Program, Science Applications International Corporation-Frederick Inc., National Cancer Institute-Frederick, Frederick, Maryland; 4Bioinformed Consulting Services, Gaithersburg, Maryland; 5Department of Environmental Medicine, NYU School of Medicine, New York, New York; 6Program in Molecular and Genetic Epidemiology, Department of Epidemiology and 7Department of Nutrition, Harvard School of Public Health; 8Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; 9Department of Epidemiology, American Cancer Society, Atlanta, Georgia; 10Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland; 11Centre de Recherche pour les Patholog; Authors' Affiliations: 1Laboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics and 2Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland; 3Core Genotyping Facility, Advanced Technology Program, Science Applications International Corporation-Frederick Inc., National Cancer Institute-Frederick, Frederick, Maryland; 4Bioinformed Consulting Services, Gaithersburg, Maryland; 5Department of Environmental Medicine, NYU School of Medicine, New York, New York; 6Program in Molecular and Genetic Epidemiology, Department of Epidemiology and 7Department of Nutrition, Harvard School of Public Health; 8Channing Laboratory, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts; 9Department of Epidemiology, American Cancer Society, Atlanta, Georgia; 10Department of Chronic Disease Prevention, National Institute for Health and Welfare, Helsinki, Finland; 11Centre de Recherche pour les Patholog Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute of Medical Research, and University of Sydney Sydney New South Wales Australia Authors' Affiliations: 1Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland; 2Department of Preventive Medicine, University of Southern California, Los Angeles, California; 3New York University School of Medicine, New York, New York; 4Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; 5Harvard School of Public Health, Boston, Massachusetts; 6German Cancer Research Center (DKFZ), Heidelberg, Germany; 7Department of Urology, University of Colorado Health Sciences Center, Aurora, Colorado; 8Department of Epidemiology, American Cancer Society, Atlanta, Georgia; 9Kaiser Permanente, Denver, Colorado; 10Cancer Research Center, University of Hawaii, Honolulu, Hawaii; 11Imperial College, London, United Kingdom; and 12Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom School for Health, Wolfson Research Institute, University of Durham Queen's Campus, University Boulevard, Thornaby, Stockton on Tees TS17 6BH, UK Royal North Shore Hospital University of Sydney Sydney New South Wales Australia Department of Nutrition Harvard School of Public Health Boston MA 02115 USA; Department of Epidemiology and Statistical Genetics Harvard School of Public Health Boston MA 02115 USA New England Baptist Hospital, Boston, Massachusetts, and University of Sydney Sydney Australia Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, Guangdong, China; Department of Rheumatology, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia 1Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, Massachusetts;; 2Department of Epidemiology, Harvard Center for Cancer Prevention and; 3Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts; and Authors' Affiliations: 1Department of Epidemiology, Harvard School of Public Health; 2Channing Laboratory and 3Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School; 4Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts; 5Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; 6GlaxoSmithKline R&D, Worldwide Epidemiology (Oncology), Collegeville, Pennsylvania; and 7Research Reactor Center, University of Missouri-Columbia, Columbia, Missouri; Authors' Affiliations: 1Department of Epidemiology, Harvard School of Public Health; 2Channing Laboratory and 3Preventive Medicine, Brigham and Women's Hospital and Harvard Medical School; 4Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts; 5Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; 6GlaxoSmithKline R&D, Worldwide Epidemiology (Oncology), Collegeville, Pennsylvania; and 7Research Reactor Center, University of Missouri-Columbia, Columbia, Missouri Division of Research, New England Baptist Hospital, Boston, MA, USA Rheumatology Department, Royal North Shore Hospital, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, New South Wales, Australia 1Department of Epidemiology,; 3Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, Massachusetts, and; 4Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, Massachusetts Authors' Affiliations: Department of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine and 5Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham and Women's Hospital; 6Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, Massachusetts; 7Division of Cancer Epidemiology and 8Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany; 9Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville; 10Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda; 11Core Genotyping Facility, Frederick National Laboratory for Cancer Research, Gaithersburg, Maryland; 12Institut National de la Santé et de la Recherche Medicale (INSERM), Centre for Research in Epidemiology and Population Health, Institut Gustave Roussy; 13Paris South University, Villejuif; 14International Agency for Research on Cancer (IARC), Lyon, France; 15Epidemiolog; Authors' Affiliations: Department of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine and 5Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham and Women's Hospital; 6Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, Massachusetts; 7Division of Cancer Epidemiology and 8Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany; 9Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville; 10Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda; 11Core Genotyping Facility, Frederick National Laboratory for Cancer Research, Gaithersburg, Maryland; 12Institut National de la Santé et de la Recherche Medicale (INSERM), Centre for Research in Epidemiology and Population Health, Institut Gustave Roussy; 13Paris South University, Villejuif; 14International Agency for Research on Cancer (IARC), Lyon, France; 15Epidemiolog; Authors' Affiliations: Department of 1Nutrition, 2Epidemiology, and 3Biostatistics, Harvard School of Public Health; 4Channing Division of Network Medicine and 5Divisions of Preventive Medicine and Aging, Department of Medicine, Brigham and Women's Hospital; 6Department of Ambulatory Care and Prevention, Harvard Medical School, Boston, Massachusetts; 7Division of Cancer Epidemiology and 8Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany; 9Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville; 10Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda; 11Core Genotyping Facility, Frederick National Laboratory for Cancer Research, Gaithersburg, Maryland; 12Institut National de la Santé et de la Recherche Medicale (INSERM), Centre for Research in Epidemiology and Population Health, Institut Gustave Roussy; 13Paris South University, Villejuif; 14International Agency for Research on Cancer (IARC), Lyon, France; 15Epidemiolog The University of Sydney, Sydney Musculoskeletal Health and the Kolling Institute Faculty of Medicine and Health and the Northern Sydney Local Health District Sydney Australia; Department of Rheumatology Royal North Shore Hospital St Leonards Australia 3 Northern Clinical School, University of Sydney, St. Leonards, Sydney, New South Wales, Australia Authors' Affiliations: 1Program in Molecular and Genetic Epidemiology, Departments of 2Epidemiology, 3Nutrition, and 4Biostatistics, Harvard School of Public Health; 5Division of Aging, Department of Medicine, Brigham and Women's Hospital; 6Department of Medicine, Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School; 7Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC) and Geriatric Research, Education, and Clinical Center (GRECC), Boston Veterans Affairs Healthcare System, Boston, Massachusetts; 8Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; 9Cancer Research Center of Lyon, Centre Léon Bérard, INSERM U1052; 10International Agency for Research on Cancer, Lyon, France; 11Departments of Medicine and Epidemiology and Biostatistics, School of Public Health, Imperial College, London; 12Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Ki; Authors' Affiliations: 1Program in Molecular and Genetic Epidemiology, Departments of 2Epidemiology, 3Nutrition, and 4Biostatistics, Harvard School of Public Health; 5Division of Aging, Department of Medicine, Brigham and Women's Hospital; 6Department of Medicine, Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School; 7Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC) and Geriatric Research, Education, and Clinical Center (GRECC), Boston Veterans Affairs Healthcare System, Boston, Massachusetts; 8Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; 9Cancer Research Center of Lyon, Centre Léon Bérard, INSERM U1052; 10International Agency for Research on Cancer, Lyon, France; 11Departments of Medicine and Epidemiology and Biostatistics, School of Public Health, Imperial College, London; 12Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Ki; Authors' Affiliations: 1Program in Molecular and Genetic Epidemiology, Departments of 2Epidemiology, 3Nutrition, and 4Biostatistics, Harvard School of Public Health; 5Division of Aging, Department of Medicine, Brigham and Women's Hospital; 6Department of Medicine, Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School; 7Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC) and Geriatric Research, Education, and Clinical Center (GRECC), Boston Veterans Affairs Healthcare System, Boston, Massachusetts; 8Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; 9Cancer Research Center of Lyon, Centre Léon Bérard, INSERM U1052; 10International Agency for Research on Cancer, Lyon, France; 11Departments of Medicine and Epidemiology and Biostatistics, School of Public Health, Imperial College, London; 12Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Ki 1Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School;; 2Department of Nutrition and; 3Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts and Department of Rheumatology, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute University of Sydney Australia Department of Epidemiology Harvard T.H. Chan School of Public Health Boston Massachusetts United States of America; Channing Division of Network Medicine Department of Medicine Brigham and Women's Hospital Boston Massachusetts United States of America; Broad Institute of Harvard and MIT Cambridge Massachusetts United States of America Division of Research, New England Baptist Hospital, 125 Parker Hill Ave, Boston, MA, 02120, USA, Clinical Epidemiology Research and Training Unit, Arthritis Center, Boston University, MA 02118, USA. [email protected] University of Sydney Sydney, New South Wales Australia Newcastle University, Newcastle, UK. 1Harvard School of Public Health, Departments of Nutrition,; 2Epidemiology, and; 9Harvard Center for Cancer Prevention, Boston, Massachusetts;; 10Channing Laboratory, Harvard Medical School/Brigham and Womens’ Hospital, Boston, Massachusetts; Kolling Institute and Royal North Shore Hospital, University of Sydney Sydney Australia Royal North Shore Hospital, Northern Clinical School, Kolling Institute of Medical Research, Institute of Bone and Joint Research, and University of Sydney Sydney New South Wales Australia Sydney Musculoskeletal Health Kolling Institute of Medical Research Faculty of Medicine and Health University of Sydney Sydney New South Wales Australia 1Department of Epidemiology, Harvard School of Public Health;; 4Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts;; 9The Broad Institute of the Massachusetts Institute of Technology and Harvard University, Cambridge, Massachusetts Rheumatology Department, Royal North Shore Hospital and Sydney Musculoskeletal Health, Kolling Institute University of Sydney Sydney New South Wales Australia Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA Authors' Affiliations: Departments of 1Epidemiology, 2Biostatistics; and 3Nutrition, Harvard School of Public Health; 4Channing Laboratory; and 5Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School; 6Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 7Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; 8Division of Hematology and Medical Oncology, Mount Sinai School of Medicine, New York, New York; and 9The Eli and Edythe L. Broad Institute, Cambridge, Massachusetts; Authors' Affiliations: Departments of 1Epidemiology, 2Biostatistics; and 3Nutrition, Harvard School of Public Health; 4Channing Laboratory; and 5Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School; 6Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 7Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; 8Division of Hematology and Medical Oncology, Mount Sinai School of Medicine, New York, New York; and 9The Eli and Edythe L. Broad Institute, Cambridge, Massachusetts; Authors' Affiliations: Departments of 1Epidemiology, 2Biostatistics; and 3Nutrition, Harvard School of Public Health; 4Channing Laboratory; and 5Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School; 6Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 7Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; 8Division of Hematology and Medical Oncology, Mount Sinai School of Medicine, New York, New York; and 9The Eli and Edythe L. Broad Institute, Cambridge, Massachusetts; Authors' Affiliations: Departments of 1Epidemiology, 2Biostatistics; and 3Nutrition, Harvard School of Public Health; 4Channing Laboratory; and 5Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School; 6Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 7Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; 8Division of Hematology and Medical Oncology, Mount Sinai School of Medicine, New York, New York; and 9The Eli and Edythe L. Broad Institute, Cambridge, Massachusetts From the Department of Data Sciences, Dana–Farber Cancer Institute (D.H.), Boston University (R.B.D.), Harvard T.H. Chan School of Public Health (D.H., D.J.H.), and the Department of Health Care Policy, Harvard Medical School, and the Department of Biostatistics, Harvard T.H. Chan School of Public Health (S.-L.T.N.) — all in Boston; the Department of Biostatistics and Center for Statistical Sciences, Brown University School of Public Health, Providence, RI (C.G., J.W.H.); and Nuffield Department of... 1Program in Molecular and Genetic Epidemiology, Department of Epidemiology, and; 2Department of Nutrition, Harvard School of Public Health;; 3Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of Sydney Sydney New South Wales Australia 1Nutrition, Departments of; 2Epidemiology, and; 4Department of Medicine, Channing Laboratory and; 6Harvard Center for Cancer Prevention, Boston, Massachusetts; From the Departments of Epidemiology and Nutrition, Harvard School of Public Health, Boston (D.J.H.); the Public Health Foundation of India, New Delhi (K.S.R.); and the World Heart Federation, Geneva (K.S.R.). University of Sydney Sydney Australia Authors' Affiliations: 1Channing Laboratory, 2Division of Preventive Medicine, Department of Medicine; 3Clinical Research Program, Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School; 4Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts; 5Program on Genomics and Nutrition, Department of Epidemiology, School of Public Health, University of California, Los Angeles, California; 6Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington; 7Pacific Health Research Institute, Honolulu, Hawaii; 8Medstar Research Institute and Howard University, Washington, District of Columbia; and 9Department of Social and Preventive Medicine, School of Public Health and Health Professions, University of Buffalo, Buffalo, New York; Authors' Affiliations: 1Channing Laboratory, 2Division of Preventive Medicine, Department of Medicine; 3Clinical Research Program, Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School; 4Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts; 5Program on Genomics and Nutrition, Department of Epidemiology, School of Public Health, University of California, Los Angeles, California; 6Fred Hutchinson Cancer Research Center, Division of Public Health Sciences, Seattle, Washington; 7Pacific Health Research Institute, Honolulu, Hawaii; 8Medstar Research Institute and Howard University, Washington, District of Columbia; and 9Department of Social and Preventive Medicine, School of Public Health and Health Professions, University of Buffalo, Buffalo, New York 5Program in Molecular and Genetic Epidemiology and Authors' Affiliations: 1Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, Bethesda, Maryland and 2Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts 1Channing Laboratory and; 3Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard University School of Public Health and Channing LaboratoryHarvard Medical School, and Brigham and Women's Hospital 180 Langwood Avenue Boston Massachusetts 02115 USA King's Fund Institute for the Breast Working Group of the Cancer Intervention and Surveillance Modeling Network (CISNET), in collaboration with the Breast Cancer Surveillance Consortium (BCSC), and the Cancer Risk Estimates Related to Susceptibility (CARRIERS) Consortium Department of Epidemiology, Harvard T.H. Chan School of Public Health , Boston, MA, USA; Nuffield Department of Population Health, University of Oxford , Oxford, UK Health and Exercise Sciences Research Group University of Stirling Scotland UK Rheumatology Department, Royal North Shore Hospital and Sydney Musculoskeletal Health, Kolling Institute, University of Sydney, Sydney, New South Wales, Australia Institute of Bone and Joint Research, Royal North Shore Hospital, University of Sydney, Australia. [email protected] Department of Epidemiology Harvard School of Public Health Boston Massachusetts USA; Program in Molecular and Genetic Epidemiology Harvard School of Public Health Boston Massachusetts USA Program in Molecular and Genetic Epidemiology and; Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA, 1Epidemiology, Departments of; 3Nutrition, Harvard School of Public Health, Boston, Massachusetts;; 4Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; and; 5Harvard Center for Cancer Prevention, Boston, Massachusetts Nuffield Department of Population Health University of Oxford Oxford UK the Departments of Epidemiology (L.C.-T., W.C.W., D.S., D.J.H., G.C., G.A.C., M.J.S.), Nutrition (W.C.W., G.C., M.J.S.), and Biostatistics (D.S.), Harvard School of Public Health, and the Channing Laboratory (W.C.W., J.E.M., D.J.H., G.C., G.A.C., M.J.S.) and Division of Preventive Medicine (J.E.M.), Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass. 2Channing Laboratory, Department of Medicine Brigham and Women's Hospital; Departments of; 3Epidemiology and; 4Nutrition, Harvard School of Public Health; and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Nuffield Department of Population Health, University of Oxford, Oxford, UK Institute of Bone and Joint Research, Kolling Institute of Medical Research, University of Sydney, Sydney, Australia; Sydney Medical School, University of Sydney, Sydney, Australia; Rheumatology Department, Royal North Shore Hospital, Sydney, Australia Authors' Affiliations: 1School of Population Health, Centre for Molecular Environmental, Genetic and Analytic Epidemiology, 2Department of Pathology, University of Melbourne; 3Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia; 4Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California at Los Angeles; 5Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; 6University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen, Germany; 7Area de Epidemiologia Ambiental y Cáncer, Centro Nacional de Epidemiologia, Instituto de Salud Carlos III; 8Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiologia y Salud Pública CIBERESP); 9Human Genetics Group, Spanish National Cancer Research Centr; Authors' Affiliations: 1School of Population Health, Centre for Molecular Environmental, Genetic and Analytic Epidemiology, 2Department of Pathology, University of Melbourne; 3Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia; 4Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California at Los Angeles; 5Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; 6University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen, Germany; 7Area de Epidemiologia Ambiental y Cáncer, Centro Nacional de Epidemiologia, Instituto de Salud Carlos III; 8Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiologia y Salud Pública CIBERESP); 9Human Genetics Group, Spanish National Cancer Research Centr; Authors' Affiliations: 1School of Population Health, Centre for Molecular Environmental, Genetic and Analytic Epidemiology, 2Department of Pathology, University of Melbourne; 3Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia; 4Department of Medicine, Division of Hematology and Oncology, David Geffen School of Medicine, University of California at Los Angeles; 5Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; 6University Breast Center Franconia, Department of Gynecology and Obstetrics, University Hospital Erlangen Friedrich-Alexander University Erlangen-Nuremberg, Comprehensive Cancer Center Erlangen-Nuremberg, Erlangen, Germany; 7Area de Epidemiologia Ambiental y Cáncer, Centro Nacional de Epidemiologia, Instituto de Salud Carlos III; 8Consortium for Biomedical Research in Epidemiology and Public Health (CIBER en Epidemiologia y Salud Pública CIBERESP); 9Human Genetics Group, Spanish National Cancer Research Centr Dr. Hunter is a professor in the Departments of Epidemiology and Nutrition at the Harvard School of Public Health, Boston, and a statistical consultant to the Journal. Dr. Khoury is the director of the National Office of Public Health Genomics at the Centers for Disease Control and Prevention, Atlanta. Dr. Drazen is the editor-in-chief of the Journal. Royal North Shore Hospital and University of Sydney Sydney New South Wales Australia 6Epidemiology and; 7Nutrition and; 8Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts; and; 9Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts Authors' Affiliations: 1Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, NIH, Bethesda, Maryland; Departments of 2Epidemiology and 3Nutrition, Harvard School of Public Health; Divisions of 4Preventive Medicine, 5Aging, and 6Cardiovascular Disease, 7Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; 8VA Boston Healthcare System, Boston, Massachusetts; 9Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; 10Epidemiology Research Program, American Cancer Society, Atlanta, Georgia; 11Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany; 12Department of Biology, University of Pisa, Pisa; 13Cancer Research and Prevention Institute—ISPO, Florence, Italy; 14Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; 15National Institute for Public Hea; Authors' Affiliations: 1Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, NIH, Bethesda, Maryland; Departments of 2Epidemiology and 3Nutrition, Harvard School of Public Health; Divisions of 4Preventive Medicine, 5Aging, and 6Cardiovascular Disease, 7Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; 8VA Boston Healthcare System, Boston, Massachusetts; 9Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; 10Epidemiology Research Program, American Cancer Society, Atlanta, Georgia; 11Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany; 12Department of Biology, University of Pisa, Pisa; 13Cancer Research and Prevention Institute—ISPO, Florence, Italy; 14Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; 15National Institute for Public Hea; Authors' Affiliations: 1Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, NIH, Bethesda, Maryland; Departments of 2Epidemiology and 3Nutrition, Harvard School of Public Health; Divisions of 4Preventive Medicine, 5Aging, and 6Cardiovascular Disease, 7Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; 8VA Boston Healthcare System, Boston, Massachusetts; 9Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; 10Epidemiology Research Program, American Cancer Society, Atlanta, Georgia; 11Genomic Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany; 12Department of Biology, University of Pisa, Pisa; 13Cancer Research and Prevention Institute—ISPO, Florence, Italy; 14Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; 15National Institute for Public Hea From Mayo Clinic, Rochester, MN (C. Hu, S.N.H., R.G., K.Y.L., J.N., J.L., S. Yadav, N.J.B., T.L., J.E.O., C.S., C.M.V., E.C.P., F.J.C.); Harvard University T.H. Chan School of Public Health (H.H., C.G., D.J.H., P.K.), Slone Epidemiology Center at Boston University (K.A.B., J.R.P., L.R.), and Brigham and Women’s Hospital (H.E.) — all in Boston; Qiagen, Hilden, Germany (R.S., J.K.); Roswell Park Comprehensive Cancer Center, Buffalo (C.B.A., S. Yao), and Weill Cornell Medicine, New York (R.T.) — both in New... The University of Sydney; Chair, Institute of Bone and Joint Research and Kolling Institute; Royal North Shore Hospital St Leonards Sydney NSW Australia 2065 Sydney Musculoskeletal Health, Kolling Institute, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia; Clinical Research Centre, Zhujiang Hospital, Southern Medical University, Guangzhou, China; Rheumatology Department, Royal North Shore Hospital, St Leonards, Australia 22Nurses' Health Study: Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts (D.J.H., P.K., and D.G.C.) and Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts (D.J.H. and S.E.H.); Discovery Research, GlaxoSmithKline, New Frontiers Science Park, Third Avenue, Harlow, Essex, U.K. CM19 5AW Authors' Affiliations:1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 2Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; 3Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts; 4Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts; 5Information Management Services, Silver Spring, Maryland; 6Division of Hematology & Transfusion Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden; 7Department of Obstetrics and Gynecology, New York University School of Medicine, New York; 8Department of Environmental Medicine, New York University School of Medicine, New York; 9New York University Cancer Institute, New York; 10National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands; 11Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, the Netherlands; 12Departme; Authors' Affiliations:1Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts; 2Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; 3Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts; 4Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts; 5Information Management Services, Silver Spring, Maryland; 6Division of Hematology & Transfusion Medicine, Department of Laboratory Medicine, Lund University, Lund, Sweden; 7Department of Obstetrics and Gynecology, New York University School of Medicine, New York; 8Department of Environmental Medicine, New York University School of Medicine, New York; 9New York University Cancer Institute, New York; 10National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands; 11Department of Gastroenterology and Hepatology, University Medical Center Utrecht, Utrecht, the Netherlands; 12Departme 2Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School; Departments of; 3Epidemiology and; 4Nutrition, Harvard School of Public Health, Boston, Massachusetts Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA; Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA Faculty of Medicine and Health, The Kolling Institute, The Institute of Bone and Joint Research 1 Department of Epidemiology, 2Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, 3Broad Institute of Harvard and MIT, Cambridge, MA 02142, 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, 5Divisions of Genetics and Endocrinology, Children's Hospital and 6Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; 1 Department of Epidemiology, 2Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, 3Broad Institute of Harvard and MIT, Cambridge, MA 02142, 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, 5Divisions of Genetics and Endocrinology, Children's Hospital and 6Department of Genetics, Harvard Medical School, Boston, MA 02115, USA; 1 Department of Epidemiology, 2Department of Biostatistics, Harvard School of Public Health, Boston, MA 02115, 3Broad Institute of Harvard and MIT, Cambridge, MA 02142, 4Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, 5Divisions of Genetics and Endocrinology, Children's Hospital and 6Department of Genetics, Harvard Medical School, Boston, MA 02115, USA 2Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School; Departments of; 3Epidemiology and Dr. Hunter is a professor in the Departments of Epidemiology and Nutrition at the Harvard School of Public Health, Boston, and a statistical consultant for the Journal. Dr. Altshuler is a professor in the Departments of Genetics and Medicine, Harvard Medical School and Massachusetts General Hospital, Boston. Dr. Rader is a professor of medicine and pharmacology and associate director of the Institute for Translational Medicine and Therapeutics, University of Pennsylvania School of Medicine, Philadelphia. Nuffield Department of Population Health, Oxford University, Oxford, UK Centre for Public Policy and Health, Wolfson Research Institute, Durham University, Stockton-on-Tees, UK Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, New South Wales, Australia. Sydney Musculoskeletal Health, University of Sydney, Sydney, New South Wales, Australia Rheumatology Department, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney 1Department of Nutrition,; 2Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health;; 4Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 1Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.; 2Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.; 7Nuffield Department of Population Health, University of Oxford, Oxford, United Kingdom. Department of Rheumatology Royal North Shore Hospital and Institute of Bone and Joint Research University of Sydney Sydney New South Wales Australia 2Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts. 1Department of Epidemiology and; 2Program in Molecular and Genetic Epidemiology, Harvard School of Public Health; and; 3Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts Harvard T. H. Chan School of Public Health, Boston, Massachusetts. Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, Massachusetts. Department of Nutrition, Harvard School of Public Health, 665 Huntington Avenue, Boston, MA 02115, U.S.A.; Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115, U.S.A.; Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115, U.S.A. for the International AMD Genomics Consortium (IAMDGC) Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA 1Departments of Epidemiology and; 2Nutrition, and; 3Harvard Center for Cancer Prevention, Harvard School of Public Health and; 4Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital, and Harvard Medical School, Boston, Massachusetts Division of Research, New England Baptist Hospital, Boston, MA. School of Medicine, Pharmacy and Health, Durham University Queen’s Campus, Stockton-on-Tees, UK University of Sydney, Sydney, Australia (D.J.H.) Rheumatology Department Royal North Shore Hospital Sydney New South Wales Australia; Kolling Institute of Medical Research, Sydney Musculoskeletal Health, Faculty of Medicine and Health University of Sydney Sydney New South Wales Australia Authors' Affiliations: Departments 1Epidemiology, 2Nutrition, and 3Biostatistics, Harvard School of Public Health; 4Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; and 5Department of Surgery, Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri; Authors' Affiliations: Departments 1Epidemiology, 2Nutrition, and 3Biostatistics, Harvard School of Public Health; 4Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; and 5Department of Surgery, Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri; Authors' Affiliations: Departments 1Epidemiology, 2Nutrition, and 3Biostatistics, Harvard School of Public Health; 4Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; and 5Department of Surgery, Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri Charming Laboratory, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School Boston, Massachusetts; Departments of Epidemiology, Harvard School of Public Health Boston, Massachusetts 1Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Departments of; 5Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, and 11Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts; From Boston University School of Medicine, Hebrew SeniorLife, Brigham and Women's Hospital, and Boston Medical Center, Boston, Massachusetts. Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health, Boston, MA Department of Epidemiology Harvard School of Public Health Boston MA; Program in Molecular and Genetic Epidemiology Harvard School of Public Health Boston MA; Department of Medicine Channing Laboratory Brigham and Women's Hospital and Harvard Medical School Boston MA Authors' Affiliations: 1Program in Molecular and Genetic Epidemiology, Departments of 2Epidemiology, 3Nutrition, and 4Biostatistics, Harvard School of Public Health; 5Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC) and Geriatric Research, Education, and Clinical Center (GRECC), Boston Veterans Affairs Healthcare System; 6Division of Aging, Department of Medicine, 7Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; 8Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; 9Genomic Epidemiology Group, German Cancer Research Center DKFZ, Heidelberg, Germany; 10Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; 11Division of Urologic Surgery, Washington University School of Medicine, St Louis, Missouri; 12National Institute for Public Health and the Environment (RIVM), Bilthoven; 13Department of Gastro; Authors' Affiliations: 1Program in Molecular and Genetic Epidemiology, Departments of 2Epidemiology, 3Nutrition, and 4Biostatistics, Harvard School of Public Health; 5Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC) and Geriatric Research, Education, and Clinical Center (GRECC), Boston Veterans Affairs Healthcare System; 6Division of Aging, Department of Medicine, 7Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; 8Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; 9Genomic Epidemiology Group, German Cancer Research Center DKFZ, Heidelberg, Germany; 10Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; 11Division of Urologic Surgery, Washington University School of Medicine, St Louis, Missouri; 12National Institute for Public Health and the Environment (RIVM), Bilthoven; 13Department of Gastro; Authors' Affiliations: 1Program in Molecular and Genetic Epidemiology, Departments of 2Epidemiology, 3Nutrition, and 4Biostatistics, Harvard School of Public Health; 5Massachusetts Veterans Epidemiology and Research Information Center (MAVERIC) and Geriatric Research, Education, and Clinical Center (GRECC), Boston Veterans Affairs Healthcare System; 6Division of Aging, Department of Medicine, 7Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts; 8Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; 9Genomic Epidemiology Group, German Cancer Research Center DKFZ, Heidelberg, Germany; 10Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; 11Division of Urologic Surgery, Washington University School of Medicine, St Louis, Missouri; 12National Institute for Public Health and the Environment (RIVM), Bilthoven; 13Department of Gastro University of Sydney Sydney Medical School and Royal North Shore Hospital Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Nuffield Department of Population Health, University of Oxford, Oxford, UK. Department of Rheumatology Royal North Shore Hospital and Kolling Institute University of Sydney Sydney New South Wales Australia Centre for Public Policy and Health, School of Medicine Pharmacy and Health, Durham University Queen’s Campus, Stockton on Tees, UK; Fuse the Centre for Translational Research in Public Health, Newcastle upon Tyne, UK Department of Epidemiology, Harvard TH Chan School of Public Health, Boston, MA 02115, USA; Program in Genetic Epidemiology and Statistical Genetics, Harvard TH Chan School of Public Health, Boston, MA 02115, USA; Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK. 6Program in Genetic Epidemiology and Statistical Genetics, Harvard School of Public Health, Boston, Massachusetts. Authors' Affiliations: 1Center for Cancer Epidemiology and Prevention; Departments of 2Health Studies, 3Medicine, and 4Human Genetics; 5Comprehensive Cancer Center, University of Chicago, Chicago, Illinois; 6Department of Health Research and Policy, Stanford University School of Medicine; 7Stanford Cancer Institute, Stanford; 8Cancer Prevention Institute of California, Fremont; 9Department of Preventive Medicine, University of Southern California, Los Angeles; 10Stanford Cancer Institute, Palo Alto, California; 11Epidemiology and Genetics Research Program; 12Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, Maryland; 13Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington; 14Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina; 15Department of Environmental Health Sciences, Columbia University Mailman School of Public Health, New York, New York; 16Integrated Cancer Genomics Division, Tr Institute of Bone and Joint Research Kolling Institute University of Sydney Sydney Australia 3Program in Molecular and Genetic Epidemiology, Harvard School of Public Health; Divisions of Rheumatology Department, Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia From the Harvard T.H. Chan School of Public Health, Boston (D.J.H., A.J.), and the Harvard Institute for Global Health, Cambridge (A.J.) — both in Massachusetts; and the University of Washington, Seattle (H.F.). Department of Rheumatology Royal North Shore Hospital Sydney NSW Australia; Kolling Institute of Medical Research Institute of Bone and Joint Research University of Sydney Sydney NSW Australia; Northern Clinical School University of Sydney Sydney NSW Australia 1Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School;; 2Department of Epidemiology,; 5Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts and Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, 181 Longwood Avenue, Boston, MA 02115; Departments of Epidemiology and Nutrition, and Harvard Center for Cancer Prevention, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115; and Department of Epidemiology, University of Groningen, Ant. Deusinglaan 1, 9700 AD, Groningen, The Netherlands 8Harvard T. H. Chan School of Public Health, Boston, Massachusetts. 4Division of Cancer Epidemiology and Genetics, and; 6Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, and; 7Channing Laboratory, Brigham and Women's Hospital, Boston, Massachusetts Rheumatology Department, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, New South Wales, Australia. Sydney Musculoskeletal Health, The University of Sydney, Sydney, New South Wales, Australia Department of Epidemiology Harvard T.H. Chan School of Public Health Boston Massachusetts USA; Program in Genetic Epidemiology and Statistical Genetics Harvard T.H. Chan School of Public Health Boston Massachusetts USA; Nuffield Department of Population Health University of Oxford Oxford UK From the Channing Laboratory, Department of Medicine, and Division of Preventive Medicine, Harvard Medical School and Brigham and Women’s Hospital; Department of Obstetrics and Gynecology, Brigham and Women’s Hospital; Departments of Epidemiology, Nutrition, and Biostatistics, Harvard School of Public Health, Boston, MA. Rheumatology Department, Royal North Shore Hospital, Sydney, New South Wales, Australia 1Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; 2Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; 3Broad Institute of Harvard and MIT Divisions of Genetics and Endocrinology and Program in Genomics, Children's Hospital Department of Genetics, and 4Channing Laboratory, Harvard Medical School, 5Department of Epidemiology, Harvard School of Public Health, and 6Department of Medicine, Brigham and Women's Hospital, VA Boston and Harvard Medical School, Boston, Massachusetts; 7Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; 8Department of Clinical Sciences, Malmö University Hospital, Lund University, Malmö, Sweden; 9German Institute of Human Nutrition, Department of Epidemiology Potsdam-Rehbűcke, Germany; 10National Institute of Public Health and Environment (RIVM), Bilthoven, the Netherlands; 11Department of Epidemiology, Americ; 1Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; 2Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; 3Broad Institute of Harvard and MIT Divisions of Genetics and Endocrinology and Program in Genomics, Children's Hospital Department of Genetics, and 4Channing Laboratory, Harvard Medical School, 5Department of Epidemiology, Harvard School of Public Health, and 6Department of Medicine, Brigham and Women's Hospital, VA Boston and Harvard Medical School, Boston, Massachusetts; 7Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; 8Department of Clinical Sciences, Malmö University Hospital, Lund University, Malmö, Sweden; 9German Institute of Human Nutrition, Department of Epidemiology Potsdam-Rehbűcke, Germany; 10National Institute of Public Health and Environment (RIVM), Bilthoven, the Netherlands; 11Department of Epidemiology, Americ; 1Cancer Epidemiology Unit, Nuffield Department of Clinical Medicine, University of Oxford, Oxford, United Kingdom; 2Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; 3Broad Institute of Harvard and MIT Divisions of Genetics and Endocrinology and Program in Genomics, Children's Hospital Department of Genetics, and 4Channing Laboratory, Harvard Medical School, 5Department of Epidemiology, Harvard School of Public Health, and 6Department of Medicine, Brigham and Women's Hospital, VA Boston and Harvard Medical School, Boston, Massachusetts; 7Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; 8Department of Clinical Sciences, Malmö University Hospital, Lund University, Malmö, Sweden; 9German Institute of Human Nutrition, Department of Epidemiology Potsdam-Rehbűcke, Germany; 10National Institute of Public Health and Environment (RIVM), Bilthoven, the Netherlands; 11Department of Epidemiology, Americ 1Program in Molecular and Genetic Epidemiology and; 2Department of Epidemiology, Harvard School of Public Health, and; 3Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA. Program in Genetic Epidemiology and Statistical Genetics Department of Epidemiology, Harvard School of Public Health, 677 Huntington Avenue Boston MA Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts; Channing Laboratory, Harvard Medical School, Boston, Massachusetts; Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T. H. Chan School of Public Health, Boston, Massachusetts 54Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. 2Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA; Program in Genetic Epidemiology and Statistical Genetics, Harvard T.H. Chan School of Public Health, Boston, MA, USA Rheumatology Department, Royal North Shore Hospital and Institute of Bone and Joint Rersearch, Kolling Institute, University of Sydney, Australia. [email protected]. University of Oxford, Oxford, United Kingdom New England Baptist Hospital, Boston, MA, USA From the Nuffield Department of Population Health, University of Oxford, Oxford, UK (D.J.H.). Royal North Shore Hospital and Northern Clinical School University of Sydney Sydney New South Wales Australia Program in Molecular and Genetic Epidemiology, Department of Epidemiology, Harvard School of Public Health, Boston, MA 02115; Nuffield Department of Population Health, University of Oxford , Oxford, Oxfordshire OX3 7LF , UK; Department of Epidemiology, Harvard T.H. Chan School of Public Health , Boston, MA 02115 , USA Julio Frenk is with the Office of the Dean, Harvard T. H. Chan School of Public Health, Boston, and the Harvard Kennedy School of Government, Cambridge, MA. David J. Hunter is with the Office of the Dean, Harvard T. H. Chan School of Public Health. Ian Lapp is with the Department of Global Health and Population, Harvard T. H. Chan School of Public Health. 1Epidemiology and Departments of; 3Program in Genetic and Molecular Epidemiology, Harvard School of Public Health; and; 4Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts Department of Epidemiology and; Channing Laboratory, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts, USA Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts.; Channing Laboratory, Department of Medicine, Harvard Medical School, and Brigham and Women's Hospital, Boston, Massachusetts.; Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, Massachusetts. Boston University Clinical Epidemiology Research and Training Unit, Arthritis Center, the Department of Medicine at Boston Medical Center, Boston, Massachusetts 02118, USA. [email protected] Department of Rheumatology, Royal North Shore Hospital and Institute of Bone and Joint Research, University of Sydney, Sydney, NSW, Australia Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, MA, USA. Sydney Musculoskeletal Health Arabanoo Precinct Kolling Institute Faculty of Medicine and Health The University of Sydney Sydney New South Wales Australia Channing Division of Network Medicine, Department of Medicine Brigham and Women's Hospital, and Harvard Medical School Boston Massachusetts; Department of Epidemiology Harvard School of Public Health Boston Massachusetts; Department of Nutrition Harvard School of Public Health Boston Massachusetts Rheumatology Department, Royal North Shore Hospital and Institute of Bone and Joint Research, Kolling Institute, University of Sydney, Sydney, Australia University of Oxford, Nuffield Department of Population Health, Oxford, United Kingdom. Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts. Rheumatology Department, Royal North Shore Hospital & Institute of Bone & Joint Research, Kolling Institute, University of Sydney, Sydney, Australia National Centre for Sport and Exercise Medicine, School of Sport, Exercise, and Health Sciences, Loughborough University, Loughborough, United Kingdom; Translational Chemical Biology Research Group, School of Sport, Exercise, and Health Sciences, Loughborough University, Loughborough, United Kingdom 1Department of Epidemiology and; 2Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, and; 3Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 7Department of Epidemiology, Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts. Program in Molecular and Genetic Epidemiology Harvard School of Public Health Boston Massachusetts; Department of Epidemiology Harvard School of Public Health Boston Massachusetts; Channing Laboratory Department of Medicine Harvard Medical School and Brigham and Women's Hospital Boston Massachusetts Department of Epidemiology, Harvard School of Public Health, Harvard University, Boston, MA, USA; Department of Nutrition, Harvard School of Public Health, Boston, MA, USA. Lecturer in Adult Health/Deputy Programme Leader, BSc Adult Nursing, University of the West of Scotland, Paisley Campus Authors' Affiliations: 1Program in Molecular and Genetic Epidemiology; Departments of 2Epidemiology, and 3Nutrition, Harvard School of Public Health, Boston, Massachusetts; 4Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; 5Genomic Epidemiology Group, 6Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; 7Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom; 8Cancer Epidemiology and Genetics, and 9Cancer Prevention, National Cancer Institute, Bethesda, Maryland; 10Department of Epidemiology, Deutsches Institut für Ernährungsforschung, Potsdam-Rehbrücke, Germany; 11National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands; Divisions of 12Preventive Medicine and 13Aging, Department of Medicine, Brigham and Women's Hospital, and 14Harvard Medical School, Boston, Massachusetts; 15Department of Ambulatory Care and Prevention, 16Division for Research and Educati; Authors' Affiliations: 1Program in Molecular and Genetic Epidemiology; Departments of 2Epidemiology, and 3Nutrition, Harvard School of Public Health, Boston, Massachusetts; 4Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California; 5Genomic Epidemiology Group, 6Division of Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany; 7Cancer Epidemiology Unit, University of Oxford, Oxford, United Kingdom; 8Cancer Epidemiology and Genetics, and 9Cancer Prevention, National Cancer Institute, Bethesda, Maryland; 10Department of Epidemiology, Deutsches Institut für Ernährungsforschung, Potsdam-Rehbrücke, Germany; 11National Institute for Public Health and the Environment (RIVM), Bilthoven, the Netherlands; Divisions of 12Preventive Medicine and 13Aging, Department of Medicine, Brigham and Women's Hospital, and 14Harvard Medical School, Boston, Massachusetts; 15Department of Ambulatory Care and Prevention, 16Division for Research and Educati From the Centre for Health, Exercise, and Sports Medicine, Department of Physiotherapy, University of Melbourne, Melbourne, VIC (K.L.B.), and the Institute of Bone and Joint Research, Kolling Institute, University of Sydney, and the Rheumatology Department, Royal North Shore Hospital, Sydney (D.J.H.) — all in Australia. Department of Epidemiology and Biostatistics Harvard School of Public Health Boston MA University of Sydney, and Royal North Shore Hospital and Institute of Bone and Joint Research Sydney, New South Wales Australia 1Epidemiology and Departments of; 2Nutrition, and; 3Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, Massachusetts, and; 4Channing Laboratory, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts Department of Nutrition Harvard School of Public Health Boston MA; Department of Epidemiology Harvard School of Public Health Boston MA; Channing Division of Network Medicine, Department of Medicine Brigham and Women's Hospital and Harvard Medical School Boston MA From Massachusetts General Hospital, Brigham and Women's Hospital, Dana-Farber Cancer Institute, Harvard Medical School, and Harvard School of Public Health, Boston, Massachusetts. 1Departments of Nutrition,; 2Epidemiology, and the; 3Harvard Center for Cancer Prevention, Harvard School of Public Health, Boston, MA and; 4Channing Laboratory, Program in Genetic Epidemiology and Statistical Genetics, Department of Epidemiology, Harvard School of Public Health Boston MA Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA; Harvard School of Public Health, Boston, Massachusetts, USA; Harvard Medical School, Boston, Massachusetts, USA Sydney Musculoskeletal Health Kolling Institute Rheumatology Department The University of Sydney Royal North Shore Hospital Sydney Australia Charming Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Harvard School of Public Health Boston, Massachusetts; Departments of Epidemiology, Harvard School of Public Health Boston, Massachusetts University of Sydney and Royal North Shore Hospital Sydney New South Wales Australia Authors' Affiliations: 1Public Health Sciences Division, Fred Hutchinson Cancer Research Center; 2Department of Epidemiology, School of Public Health, University of Washington; 3Department of Biostatistics, University of Washington, Seattle; Divisions of 4Cancer Epidemiology, 5Clinical Epidemiology and Aging Research, and 6Preventive Oncology, German Cancer Research Center, Heidelberg, Germany; 7Department of Internal Medicine, University of Utah Health Sciences Center, Salt Lake City; 8Translational Genomics Research Institute, Phoenix; 9Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School; 10Program in Molecular and Genetic Epidemiology, Department of Epidemiology, and 11Departments of Epidemiology and Nutrition, Harvard School of Public Health; 12Department of Medical Oncology, Dana-Farber Cancer Institute; 13Division of Gastroenterology, Massachusetts General Hospital and Harvard Medical School, Boston; 14,15Ontario Institute for Cancer Research; 16Department of Surgery, Universit Division of Research, New England Baptist Hospital, Boston, Massachusetts 02120, USA. 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