http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_4f995265ebb6ad5583c07cdae93efced
Outgoing Links
Predicate | Object |
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family-name | Zhang Ming Zhang |
name | Ming Zhang |
given-name | Ming |
organization-name | Key Laboratory for Poultry Genetics and Breeding of Jiangsu Province Institute of Poultry Science Chinese Academy of Agricultural Science Yangzhou China Department of Epidemiology and Biostatistics Key Laboratory for Environment and Health School of Public Health Tongji Medical College Huazhong University of Sciences and Technology Wuhan China Hainan University‐HSF/LWL Collaborative Innovation Laboratory, School of Food Science and Engineering Hainan University Haikou China Qinghai Provincial Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810008, China; Key Laboratory of Tibetan Medicine Research, Chinese Academy of Sciences, Xining 810008, China Department of Osteocarcinoma Institute, Central South University, Changsha, China. Center for Pulmonary and Infectious Disease Control, The University of Texas Health Center at Tyler, Tyler, Texas 757102 State Key Laboratory and Institute of Elemento-Organic Chemistry Haihe Laboratory of Sustainable Chemical Transformations Frontiers Science Center for New Organic Matter College of Chemistry Nankai University 94 Weijin Road Tianjin 300071 China Hangzhou Environmental Monitoring Central Station, Hangzhou 310007, China. [email protected] Artie McFerrin Department of Chemical Engineering, Texas A&M University, College Station, Texas 77843-3122, United States Department of Otorhinolaryngology, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai 200031, China. Department of Speech Pathology and Audiology and Department of Otolaryngology—Head and Neck Surgery, University of Iowa, Iowa City, Iowa 52242 Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, People's Republic of China Department of Anesthesiology SUNY Downstate Medical Center Brooklyn NY USA; Department of Orthopedics SUNY Downstate Medical Center Brooklyn NY USA Department of Chemistry, University of California, Davis, California 95616, United States, Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou510006, China Department of Gastroenterology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, China Ludwig Center, Howard Hughes Medical Institute and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University School of Medicine, Baltimore, MD 21287; Department of Medical Imaging the First Affiliated Hospital of Xi'an Jiaotong University Xi'an China 1Department of Biochemistry and Molecular Genetics, Northwestern University Feinberg School of Medicine, Chicago, Illinois. Postdoctoral Fellow, Department of Anesthesia and Critical Care, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts. Center for Infectious Diseases, Beijing Youan Hospital, Capital Medical University, China; Department of Dermatology, Beijing Youan Hospital, Capital Medical University, China School of Chemical Engineering and Technology, Tianjin University, 300072 Tianjin, P.R. China Department of Breast Surgery Harbin Medical University Cancer Hospital Harbin China Division of Cardiovascular Diseases, Mayo College of Medicine, Rochester, MN Key Laboratory of Animal Genetics, Breeding and Reproduction in the Plateau Mountainous Region; Cell and Molecular Biology (PhD); Animal Department; Guizhou University; Guiyang 550025 Department of Ultrasonography, Second Xiangya Hospital, Central South University, Changsha 410011, China. Key Laboratory of Qinghai-Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Sichuan Province and Ministry of Education, Institute of Qinghai-Tibetan Plateau, Southwest Minzu University, Chengdu, People’s Republic of China Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, PR China Department of Biomedical Engineering Faculty of Engineering The Hong Kong Polytechnic University Hong Kong SAR People's Republic of China; Department of Kinesiology Shenyang Sports Institute Shenyang People's Republic of China Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan China Nanchong Hospital of Traditional Chinese Medicine, Nanchong 637000, Sichuan, China Department of Chemistry, Shantou University 243 Da Xue Road, Shantou, Guangdong 515063, China Department of Digestive Diseases, Second Affiliated Hospital, Chongqing University of Medical Sciences, Chongqing 400010, China. [email protected] Global Health Institute, École Polytechnique Fédérale de Lausanne, Lausanne, Switzerland 4Hebei General Hospital, Shijiazhuang, China. Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China The Key Laboratory of Carbohydrate Chemistry and Biotechnology; Ministry of Education; School of Biotechnology; Jiangnan University; Wuxi 214122, P. R. China Department of Head and Neck Surgery, Cancer Centre of Sun Yat‑sen University, Guangzhou, Guangdong 510060, P.R. China Department of Oncology Sichuan Provincial People's Hospital Sichuan China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Lanzhou University, Lanzhou 730000, P.R. China Department of Epidemiology and Health Statistics, School of Public Health, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China Department of Pharmacology, School of Basic Medical Sciences, Jilin University, Changchun, Jilin 130021, China Department of Liver Surgery Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China General Practice Medicine Department Jiangxi Provincial People's Hospital Nanchang Jiangxi China Department of Ophthalmology, West China Hospital, Chengdu, China. Key Laboratory of Small Functional Organic Molecule, Ministry of Education and College of Life Science, Jiangxi Normal University Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University and Charlie Norwood Veterans Affairs Medical Center, Augusta, Georgia Department of Pharmacy, Guangzhou Brain Hospital Guangzhou Medical University Guangzhou China Department of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, Hubei, PR China School of Ecological and Environmental Sciences, East China Normal University, Shanghai 200241, China Center for Fuel Cell Innovation; State Key Laboratory of Material Processing and Die & Mould Technology; School of Materials Science and Engineering; Huazhong University of Science & Technology; Wuhan Department of Otorhinolaryngology, Tongji Hospital of Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430030, China. Department of Mechatronic Engineering, China University of Mining and Technology, Jiangsu, China; The Affiliated Xuzhou Rehabilitation Hospital of Xuzhou Medical University, Xuzhou Medical University, Jiangsu, China School of Biological Sciences and Medical Engineering Southeast University Nanjing China Department of General Practice, The Affiliated Luohu Hospital of Shenzhen University Medical School, Shenzhen, Guangdong, People's Republic of China; Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen University Medical School, Shenzhen, Guangdong, People's Republic of China Departments of Computer Science and Bioengineering, Rice University, Houston, Texas 77005 College of Medicine Jilin University Changchun 130021 China Department of Medical Imaging, First Affiliated Hospital, Xi'an Jiaotong University School of Medicine, Xi'an 710061, Shaanxi Province, China. Geely University of China, Beijing, Chengdu 610000, China Department of Biological Sciences, Carnegie Mellon University, Pittsburgh PA, USA Department of Preventive Medicine, Shenzhen University; Shenzhen University Health Science Center, Shenzhen 518060, Guangdong, China. Department of Infectious Disease Control and Prevention, Pizhou county Center for Disease Control and Prevention, Pizhou, Jiangsu, China State Key Laboratory of Chemical Resources Engineering; Beijing Advanced Innovation Center for Soft Matter Science and Engineering; Beijing University of Chemical Technology; Beijing; China Department of Cardiology, An Zhen Hospital Affiliated to Capital Medical University, Beijing, PR China Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, Shandong University, Jinan City, Shandong Province, China Department of Integrative Medicine, Shanghai Chest Hospital, Shanghai 200030, China Department of Gastroenterology the Affiliated Drum Tower Hospital of Nanjing University, Medical School Nanjing Jiangsu China Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China State Key Laboratory of Plant Physiology and Biochemistry College of Biological Sciences China Agricultural University Beijing 100193 China Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing, China; CAS Center for Excellence in Life and Paleoenvironment, Beijing, China; University of Chinese Academy of Sciences, Beijing, China Key Laboratory of Environmental Material and Environmental Engineering of Jiangsu Province, College of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou 225002, China Key Laboratory for Poultry Genetics and Breeding of Jiangsu Province, Poultry Institution, Chinese Academy of Agricultural Sciences Boston University Department of Computer Science Boston Massachusetts USA Geological Survey of Japan, National Institute of Advanced Industrial Science and Technology (AIST), 1-1-1, Higashi, Tsukuba, Ibaraki 305-8567, Japan Qingdao Youheng Biotechnology Co., Ltd., No. 130 Jiushui East Road, Qingdao 266199, China Qinghai Provincial Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation, Northwest Institute of Plateau Biology, CAS, 23 xin’ning road, Xining 810008, China. Fax: +86-971-6143765, +86-971-6143900; Tel: +86-971-6143765, +86-971-6143900; Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, CAS, 59 xiguan road, Xining 810001, China Key Laboratory of Vertebrate Evolution and Human Origins of Chinese Academy of Sciences, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences (CAS), Beijing 100044.; Center for Excellence in Life and Paleoenvironment, Chinese Academy of Sciences, Beijing 100044.; University of Chinese Academy of Sciences, Beijing 100049. Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China Department of Ultrasound The 2nd Xiangya Hospital of Central South University Changsha China Department of Radiation Oncology, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming, China Interdisciplinary Division of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China Jiangsu Collaborative Innovation Center of Biomedical Functional Materials, Jiangsu Key Laboratory of Bio-functional Materials, School of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, PR China Department of Medical Imaging First Affiliated Hospital of Xi'an Jiaotong University Xi'an 710061 People's Republic of China Department of Radiology, First Affiliated Hospital of Xi’an Jiaotong University, Xi'an, China From the Departments of Cardiovascular Medicine (K.W., Z.Z., L.F., A.M.L., E.J.T., M.S.P), Cell Biology (X.Z., N.M., M.Z., M.S.P.), and Molecular Cardiology (E.F.P.), and the Joseph J. Jacobs Center for Thrombosis and Vascular Biology (E.F.P., E.J.T.), Cleveland Clinic Foundation, Cleveland, Ohio. Department of Anatomy, Baotou Medical College, Inner Mongolia, China Department of Medical Imaging First Affiliated Hospital of Xi'an Jiaotong University Xi'an China Department of Respiratory Medicine, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710004, China. E-mail: [email protected]. State Key Laboratory of Agrobiotechnology China Agricultural University Beijing China Department of Pharmacology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Street, Changchun 130012, China Department of Cell Biology, College of Life Science and Technology, Jinan University, Guangzhou, China; Institute of Biomedicine, Jinan University, Guangzhou, China School of Pharmacy, Shenzhen University Medical School, Shenzhen University, Shenzhen 518055, China Thomas N. Lynn Institute for Healthcare Research, Oklahoma City, Oklahoma 73112 Department of Oral and Maxillofacial Surgery Hospital of Stomatology Guanghua School of Stomatology Sun Yat‐sen University Guangzhou China; Guangdong Provincial Key Laboratory of Stomatology Sun Yat‐sen University Guangzhou China Department of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 510370, China; Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou 510370, China College of Materials and Textiles, Key Laboratory of Advanced Textile Materials and Manufacturing Technology of the Ministry of Education, Zhejiang Sci-Tech University, Hangzhou 310018, P. R. China Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology, Collaborative Innovation Center of Advanced Catalysis & Green Manufacturing, School of Petrochemical Engineering, Changzhou University, Changzhou, Jiangsu 213164, China Frontiers Science Center for Transformative Molecules Center of Hydrogen Science, and In Situ Center for Physical Sciences School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai 200240 P. R. China Department of Psychiatry The 3rd Affiliated Hospital of Sun Yat‐sen University Guangzhou China Hangzhou Environmental Monitoring Control Station Hangzhou Zhejiang 310014 P.R. China Department of Pharmacology School of Pharmacy China Medical University Shenyang China; Liaoning Key Laboratory of Molecular Targeted Anti‐Tumor Drug Development and Evaluation China Medical University Shenyang China Andrology Laboratory, Department of Urology, the Second Hospital of Jilin University, Changchun, China Department of Dermatology, Beijing Youan Hospital, Capital Medical University, Beijing, China Key Lab of Chemical Biology of Ministry of Education, Department of Natural Products Chemistry, Shandong University, Jinan 250012, China Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing, PR China State Key Laboratory of Brain and Cognitive Science Institute of Psychology, Chinese Academy of Sciences Beijing China; Department of Psychology Dalian Medical University Dalian China Department of Ophthalmology Sichuan University West China Hospital Chengdu P. R. China Department of Dermatology The Fifth People's Hospital of Hainan Province Haikou China Center for Cell and Gene Therapy, Baylor College of Medicine, The Methodist Hospital and Texas Children's Hospital, Houston; Department of Anatomy and Department of Ultrasonography, The Second Xiangya Hospital Central South University No.139 Middle Renmin Road Changsha Hunan 410011 China Institute of Anesthesia, Department of Anatomy, Baotou Medical College, Baotou, Inner Mongolia, China Beijing National Laboratory for Condensed Matter Physics, Institute of Physics, Chinese Academy of Sciences, Beijing 100190 China Department of Spine Surgery, The First Affiliated Hospital of Dali University , Dali City , No. 32 Carlsberg Avenue, Yunnan, 671000 , China School of Chemistry and Chemical Engineering; Shanxi University; Taiyuan 030006; China Department of Epidemiology and Biostatistics and Ministry of Education Key Lab of Environment and Health, Tufts Medical Center Boston Massachusetts Department of Physics and Astronomy Shanghai Jiao Tong University Shanghai 200240 China Institute of Nuclear Science and Technology, Sichuan University, Chengdu 610064, China Hainan Provincial Key Laboratory of Tropical Medicine, Hainan Medical College, Haikou, Hainan 571199, P.R. China Authors' Affiliations: 1Center for Cell and Gene Therapy; Departments of 2Pediatrics, 3Pathology and Immunology, and 4Medicine, 5Interdepartmental Program in Translational Biology and Molecular Medicine, Baylor College of Medicine; 6Houston Methodist Hospital and Texas Children's Hospital; 7Department of Surgery, 8Michael E. DeBakey Department of Veterans Affairs Medical Center; 9Dan L. Duncan Cancer Center Division of Biostatistics, Baylor College of Medicine, Houston, Texas; and 10Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University , Wuhan 430079 , PR China State Key Laboratory and Institute of Elemento-Organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China Department of Respiratory Medicine, the Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China Division of Quantitative Sciences, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030-4009, USA. [email protected] Department of Oncology, The Affiliated Suzhou Municipal Hospital of Nanjing Medical University, Suzhou, Jiangsu 215001, P.R. China College of Optoelectronic Technology; Chengdu University of Information Technology; Chengdu 610225; China Department of Psychology, Research Center for Psychology and Behavioral Sciences Soochow University Suzhou China; Cognitive Neuroscience Laboratory Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University Okayama Japan Institute of Materials; China Academy of Engineering Physics; Jiangyou 621908; China Key Laboratory for Poultry Genetics and Breeding of Jiangsu Province, Chinese Academy of Agricultural Science, Institute of Poultry Science, Yangzhou 225125, China Department of Intensive Care Unit, Qianfoshan Hospital Affiliated to Shandong University, Jinan 250014, Shandong, China. Corresponding author: Li Tao, Email: [email protected]. Department of Neurosurgery The Second Hospital of Shandong University Jinan China Department of Psychology, Research Center for Psychology and Behavioral Sciences, Soochow University, Suzhou, China Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA Amgen Research, Amgen Inc., One Amgen Center Drive, Thousand Oaks, CA, USA. Tanz Center for Research in Neurodegenerative Diseases University of Toronto Toronto Ontario Canada Medicine (M.Z.), Chicago, Illinois 60611 Department of Clinical Medicine Fujian Medical University Fujian China Jiangxi Biotech Vocational College, Nanchang 330200, Jiangxi, China. WeiFang Medical University , Weifang, Shandong, China Department of Anesthesiology, SUNY Downstate Medical Center, Brooklyn, NY 11203 Department of Medical Imaging, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P.R. China §Inflammation, Amgen, Thousand Oaks, CA 91320 School of Design and Art, Jingdezhen Ceramic University, Jingdezhen 333403, China Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, the Fourth Military Medical University, Xi’an 710032, Shaanxi, China Department of Clinical Laboratory Changzhou Maternity and Child Health Care Hospital Affiliated with Nanjing Medical University Changzhou China Affiliated Luohu Hospital of Shenzhen University Health Science Centre Shenzhen Guangdong People's Republic of China; Study Team of Shenzhen's Sanming Project Affiliated Luohu Hospital of Shenzhen University Health Science Centre Shenzhen Guangdong People's Republic of China; Department of Epidemiology and Health Statistics, School of Public Health Shenzhen University Health Science Centre Shenzhen Guangdong People's Republic of China Department of Statistical Science Southern Methodist University Dallas Texas Department Ophthalmology The First Affiliated Hospital of Xi'an Jiao Tong University Xi'an China Department of Medical Imaging; First Affiliated Hospital of Xi'an Jiaotong University; Xi'an 710061 Peoples Republic of China Jiangsu Grain and Oil Commodity Trade Market; Nanjing; China President's Office of Union Hospital, Tongji Medical College, Huazhong University of Science and Technology (HUST), Wuhan, China Department of Orthopedics, The Liuzhou Workers’ Hospital of Guangxi Zhuang Autonomous Region, No. 47 Hongyan Road, Liu Nan District, Liuzhou 545007, Guangxi Zhuang Autonomous Region, China Research Fellow. Frontiers Science Center for Transformative Molecules School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai 200240 P. R. China Departments of Pathology, Anhui Provincial Cancer Hospital, Hefei, Anhui 230000, P.R. China Soochow University, China Department of Oncology, Johns Hopkins University Guangdong Provincial Key Laboratory of Marine Biology, Shantou University, Shantou, China; Institute of Marine Sciences, Shantou University, Shantou, China School of Computer Science and Information Engineering, Hubei University, Wuhan 430062, China Cellular Biology and Anatomy and Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology Sun Yat‐sen University Guangzhou China; Guangdong Provincial Key Laboratory of Stomatology Sun Yat‐sen University Guangzhou China Department of Experimental Pharmacology and Toxicology, School of Pharmaceutical Sciences, Jilin University, 1266 Fujin Road, Changchun 13002, Jilin, China Department of General Medicine, Honghui Hospital, Xi’an Jiaotong University, No. 555 Youyi East Road, Xi’an 710054, China State Key Laboratory of Chemo/Biosensing and Chemometrics School of Physics and Electronics Hunan University Changsha 410082 China From Jiangsu Province Key Laboratory of Anesthesiology (Z.P., Z.-Y.X., G.-F.L., M.-L.S., M.Z., L.-Y.H., Q.-Q.T., L.-J.Z., J.-L.C.) and Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology (Z.P., Z.-Y.X., G.-F.L., M.-L.S., M.Z., L.-Y.H., Q.-Q.T., L.-J.Z., J.-L.C.), Xuzhou Medical University, Xuzhou; and Department of Anesthesiology, The Affiliated Hospital of Xuzhou M Department of Psychology Suzhou University of Science and Technology Suzhou China; Faculty of Interdisciplinary Science and Engineering in Health Systems Okayama University Okayama Japan Associate Professor, School of Architecture, Univ. of Texas at Austin, 310 Inner Campus Dr., Stop B7500, Austin, TX 78712-1009. China Railway Water Group Co., Ltd., Xi'an 710100, People's Republic of China; China Tiegong Investment & Construction Group Co., Ltd., Beijing 100000, People's Republic of China School of Pharmaceutical Sciences, State Key Laboratory of Cellular Stress Biology, Fujian Provincial Key Laboratory of Innovative Drug Target Research, Xiamen University, Fujian, China Beijing National Laboratory for Condensed Matter Physics; Institute of Physics; Chinese Academy of Sciences; Beijing 100190; China Zhejiang University Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA Cancer Center Academy of Medical Sciences and Sichuan Provincial People's Hospital Affiliated Hospital of University of Electronic Science and Technology of China Chengdu China Division of Rheumatology, Allergy, and Immunology Tufts Medical Center 800 Washington Street, Box 406 Boston 02111 Massachusetts Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha, Hunan, China College of Urban Environment, Lanzhou City University, Lanzhou, China Ming Zhang Research Fellow (ACCTI Systems Manager), Australian Centre for Clinical Terminology and Information, (ACCTI), University of Wollongong, Wollongong NSW 2522, AUSTRALIA Affiliated People's Hospital of Jiangsu University, Zhenjiang, People's Republic of China. First Affiliated Hospital of School of Medicine, Xian Jiaotong University, Xian 710061, China Department of Respiratory Medicine, The Third Affiliated Hospital of Soochow University, Changzhou, Jiangsu, China (mainland) Department of Pharmacology, Basic College of Medicine, Jilin University, Changchun, People’s Republic of China Laboratory for Nanophotonics, Rice University, Houston, TX 77005, USA.; Applied Physics Graduate Program, Rice University, Houston, TX 77005, USA.; Department of Physics and Astronomy, Rice University, Houston, TX 77005, USA. Department of Medical Imaging, the First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. Beijing National Laboratory for Molecular Science (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China Department of ICU, Hangzhou Cancer Hospital, Hangzhou, 320001, Zhejiang, China Department of Medical Imaging, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, People's Republic of China College of Life Science, Capital Normal University, Xisanhuan Beilu No. 105, 100048 Beijing, China; College of Life Science, Heze University, University Road No. 2269, 274015 Shandong, China Department of Hepatobiliary Surgery, The First People's Hospital of Yibin, Yibin, Sichuan, China (mainland) State Key Laboratory of Organic–Inorganic Composites College of Materials Science and Engineering Beijing University of Chemical Technology Beijing 100029 P. R. China Talent Training Office, Health Science Center of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China Bio-X Center, Shanghai Jiao Tong University, Shanghai, China, Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China, Institutes of Biomedical Sciences, Fudan University, Shanghai, China, Shanghai Institute of Mental Health, Shanghai, China, School of Life Science, Ningxia University, Yinchuan, China, and Key Laboratory of Developmental Genetics and Neuropsychiatric Diseases (Shanghai Jiao Tong University), Ministry of Education,... School of Mathematics, Shandong University 1 , Jinan 250100, People’s Republic of China The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China. *Center for Blood Research, Harvard Medical School, Department of Ophthalmology, West China School of Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, P. R. China Orthopedics Department, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Taiyuan City, Shanxi Province 030032, P.R. China Department of Urology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Plant Protection, College of Agronomy, Sichuan Agricultural University, Chengdu 611130, China; School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China; Institute of Molecular Science, Shanxi University, Taiyuan 030006, China Tianjin Centers for Disease Control and Prevention, 76 Hualong Road, Tianjin 300011, PR China. School of Public Health Shenzhen University Health Science Center Shenzhen People's Republic of China Department of Neurology, Xiangya Hospital, Central South University, Changsha, Hunan, China Key Laboratory of Animal Models and Human Disease Mechanisms of Chinese Academy of Sciences &Yunnan Province, Kunming Institute of Zoology, Chinese Academy of Sciences (CAS) Kunming Yunnan China Department of Respiratory and Critical Care Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing 210002, China. State Key Laboratory of Bioreactor Engineering, Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China Department of Obstetics and Gynecology, Tianjin City 1st Central Hospital, Tianjin 300192, China Department of Anesthesiology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA; Department of Cell Biology, SUNY Downstate Medical Center, 450 Clarkson Avenue, Brooklyn, NY 11203, USA Beijing Key Laboratory of Advanced Functional Polymer Composites, Beijing University of Chemical Technology, Beijing 100029, China Department of Urology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai Institute of Andrology Shanghai China Department of Epidemiology and Biostatistics, University of Georgia, Athens, GA, USA State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, Guangdong Province, China Department of Anesthesiology, Southwest Hospital Army Medical University (Third Military Medical University) Chongqing China Department of Cell Biology, State University of New York Downstate Medical Center, Brooklyn, NY Department of Preventive Medicine Shenzhen University Health Sciences Center Shenzhen Guangdong People's Republic of China Institute of Cardiovascular Disease, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan, Guangdong 511500, P.R. China Department of Vascular Surgery, The Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing, China Department of Pharmacology, College of Basic Medical Sciences, School of Nursing Jilin University Changchun 130021 China Department of Pathology and Immunology, Medical School, China Three Gorges University Yichang China; Hubei Key Laboratory of Tumor Microenvironment and Immunotherapy, China Three Gorges University Yichang China; Department of Orthopedics Surgery, Puren Hospital, Wuhan University of Science and Technology Wuhan China From the Laboratory Medicine and Molecular Diagnostics (J.L.K., A.G., S.A.), Division of Anatomical Pathology, Sunnybrook Health Sciences Centre, University of Toronto; Department of Medicine (E.S., L.Z.), Division of Neurology, Sunnybrook Health Sciences Centre, University of Toronto, Ontario, Canada; School of Medicine and Institute for Advanced Study (M.Z.), Tongji University, Shanghai, China; and Tanz Centre for Research in Neurodegenerative Diseases (M.Z., P. McGoldrick, P. McKeever, J.R., E.R.... Institute of Medical Biology, Chinese Academy of Medical Sciences, and Peking Union Medical College, Kunming, PR China; Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious Disease, Kunming, PR China Department of Orthopaedic Surgery, Taizhou People’s Hospital, Jiangsu 225300, China Bio-X Institutes, Key Laboratory for the Genetics of Developmental and Neuropsychiatric Disorders (Ministry of Education), Shanghai Jiao Tong University, Shanghai, China; Institute for Nutritional Sciences, Shanghai Institute of Biological Sciences, Chinese Academy of Sciences, Shanghai, China Jiangsu Collaborative Innovation Center for Biological Functional Materials, College of Chemistry and Materials Science, Nanjing Normal University, Nanjing 210023, PR China; Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Engineering Research Center for Biomedical Function Materials, Nanjing 210023, PR China Institute of Orthopedics General Hospital of Lanzhou Military Command of the PLA Lanzhou Gansu 730050 China State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences China Agricultural University Beijing 100094 China Newborn Department Shijiazhuang Fourth Hospital Shijiazhuang Hebei China School of Chemistry and Chemical Engineering; Shanghai Jiao Tong University; Shanghai 200240; China Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart Lung and Vessel Diseases Institute of Osteocarcinoma, Second Xiangya Hospital, Central South University, Changsha 410011,China. The Institute of Genetics, College of Life Sciences, Zhejiang University, Hangzhou, China. State Key Laboratory for Agrobiotechnology, Key Laboratory of Crop Heterosis and Utilization (MOE), Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, 100193, China Comprehensive Management Department of Occupational Health, Shenzhen Prevention and Treatment Center for Occupational Diseases, Shenzhen, 518020, China First Affiliated Hospital of Xi'an Jiaotong University; Xi'an, China The Second Department of Orthopaedics, Lihuili Hospital of Ningbo Medical Center, Ningbo 315040, Zhejiang, China; [email protected]. Critical Care Medicine Department, Beijing Ditan Hospital, Capital Medical University, Beijing, China State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, P. R. China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, P. R. China Inner Mongolia Key Laboratory of Pattern Recognition and Intelligent Image Processing, School of Information Engineering, Inner Mongolia University of Science and Technology, Baotou, Inner Mongolia, China Department of Critical‐care Medicine Qianfoshan Hospital Affiliated to Shandong University Jinan Shandong, People's Republic of China Department of Medical Imaging The First Affiliated Hospital of Xi'an Jiaotong University Xi'an China Department of Pathology, Peking University International Hospital, Beijing, 102206, China State Key Laboratory of Organic/Inorganic Composites Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Beijing 100029 P. R. China Key Laboratory for Micro/Nano Optoelectronic Devices of Ministry of Education School of Physics and Electronics Hunan University Changsha 410082 China China-Central Asia “the Belt and Road” Joint Laboratory on Human and Environment Research, Key Laboratory of Cultural Heritage Research and Conservation, School of Culture Heritage, Northwest University , Xi’an , China; Shanghai Qi Zhi Institute , Shanghai , China; Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Center for Excellence in Life and Paleoenvironment, Chinese Academy of Sciences , Beijing , China Department of Neurosurgery, Jingmen No. 2 People's Hospital, Jingmen, Hubei 448000, P.R. China 1Ludwig Center, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland.; 2Howard Hughes Medical Institute, Johns Hopkins Kimmel Cancer Center, Baltimore, Maryland. Department of Ultrasound Diagnosis, The Second Xiangya Hospital of Central South University, Changsha, Hunan 410011, P.R. China Department of Physics and Astronomy and Collaborative Innovation Center of IFSA (CICIFSA) Shanghai Jiaotong University Shanghai 200240 China College of Plant Protection, Gansu Agricultural University, Biocontrol Engineering Laboratory of Crop Diseases and Pests of Gansu Province, Lanzhou 730070, Gansu Province, China Department of Biomedical Engineering, The Hong Kong Polytechnic University , Hong Kong 999077, China The Department of Medical Genetics, Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College Kunming China; Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Disease Kunming China Department of Interventional Radiology and Vascular Anomalies, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, Guangzhou 510120, China Department of Physical Medicine and Rehabilitation, Zibo Central Hospital , Zibo 255000 , China Wenzhou Medical College, Wenzhou, Zhejiang Province, China. Experimental Cardiology Laboratory, Baker IDI Heart and Diabetes Institute, Melbourne, VIC 3004, Australia *Neurology and School of Pharmaceutical Sciences Sun Yat-sen University Guangzhou 510006 China; Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences Lanzhou University Lanzhou 730000 China The Second Xiangya Hospital of Central South University, Changsha, Hunan, China SICU, Children’s Hospital of Nanjing Medical University, Nanjing, China Division of Rheumatology, Allergy, and Immunology Tufts Medical Center Boston Massachusetts; Department of Computer Science and Networking Wentworth Institute of Technology Boston Massachusetts School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules In‐situ Center for Physical Science and Center of Hydrogen Science Shanghai Jiao Tong University Shanghai 200240 China The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou 510370, China Institute of Neuroscience and Medical Technology, Department of Anatomy, Baotou Medical College, Inner Mongolia, China Department of Hepatobiliary Surgery, Shandong Provincial Third Hospital, Jinan, Shandong, P.R. China Department of Nephrology, The Affiliated Hospital of Qingdao University, Qingdao, China State Key Laboratory of Chemical Resource Engineering Beijing Engineering Research Center for the Synthesis and Applications of Waterborne Polymers Beijing University of Chemical Technology Beijing 100029 China School of Chemistry and Chemical Engineering Shanxi University Taiyuan 030006 China State Key Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering; Key Laboratory of Green Pesticide and Agricultural Bioengineering; Ministry of Education; Center for Research and Development of Fine Chemicals; Guizhou University Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Canada Key Laboratory for Micro-Nano Optoelectronic Devices of Ministry of Education, School of Physics and Electronics, State Key Laboratory for Chemo/Biosensing and Chemometrics, Hunan University, Changsha 410082, China Department of Otorhinolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030. Department of Dermatology, The General Hospital of Western Theater Command, Chengdu, Sichuan, China Department of Pharmacology, College of Basic Medical Sciences, School of Nursing, Jilin University Center for Cell and Gene Therapy, Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China; Department of General Surgery, Mianzhu Hospital of West China Hospital, Sichuan University, Mianzhu City, Sichuan Province, China Department of Gastroenterology, Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China MOE Engineering Research Center of Forestry Biomass Materials and Bioenergy, College of Materials Science and Technology, Beijing Forestry University, Beijing 100083, China Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, KY, USA Clinical Laboratory of Phase I, Institution of National Drug Clinical Trials of Guangzhou Brain Hospital, Guangzhou Medical University, 36 MingXin Road, Guangzhou 510370, China International Joint Research Laboratory of Magnetic Confinement Fusion and Plasma Physics, State Key Laboratory of Advanced Electromagnetic Engineering and Technology, School of Electrical and Electronic Engineering, Huazhong University of Science and Technology , Wuhan 430074, People’s Republic of China Endocrinology Department Lanzhou University Second Hospital Lanzhou China Frontiers Science Center for Transformative Molecules, Center of Hydrogen Science, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, P. R. China Department of Pharmacy, The Second Hospital of Dalian Medical University, Dalian, Liaoning 116027, P.R. China *Department of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan 430030, China; Department of Molecular & Cellular Biology, Baylor College of Medicine, Houston, Texas Swedish Heart and Vascular, WA (R.B., M.Z.). Department of Pediatric Surgery, The First People’s Hospital of Lianyungang, Lianyungang Hospital Affiliated to Xuzhou Medical University, The Affiliated Hospital of Kangda College, Nanjing Medical University, Lianyungang, Jiangsu, China. Hospital of Stomatology Sun Yat‐sen University Guangzhou China; Guangdong Provincial Key Laboratory of Stomatology Sun Yat‐sen University Guangzhou China; Guanghua School of Stomatology Sun Yat‐sen University Guangzhou China Department of Cardiology Beijing Anzhen Hospital, Capital Medical University Beijing China; Division of Cardiovascular Diseases Mayo Clinic Rochester Minnesota USA Department of Psychology Suzhou University of Science and Technology Suzhou China Department of Environmental Engineering; China Jiliang University; Hangzhou 310018; China 2Qinghai Provincial Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation, Northwest Institute of Plateau Biology, Chinese Academy of Science, Xining 810008, China; 5CAS Key Laboratory of Tibetan Medicine Research, Northwest Institute of Plateau Biology, Chinese Academy of Sciences, Xining 810001, China Department of Thyroid and Breast, West China Hospital of Sichuan University, Chengdu 610041, China. Department of Gastroenterology Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing China Institute for Energy Research, Jiangsu University, Zhenjiang 212013, P. R. China Department of Psychology, Soochow University, Suzhou, China †Guangdong Provincial Key Laboratory of Marine Biology, Shantou University, Shantou, China; and; ‡Marine Biology Institute, Shantou University, Shantou, China Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123, P.R. China Department of Respiratory and Critical Care Medicine, Changzhou No. 1 Hospital, Changzhou, Jiangsu 213000, P.R. China State Key Laboratory of Plant Cell and Chromosome Engineering Institute of Genetics and Developmental Biology The Innovative Academy of Seed Design Chinese Academy of Sciences Beijing China; University of Chinese Academy of Sciences Beijing China China Institute of Sport Science, Beijing, China Interdisciplinary Division of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, China; The Hong Kong Polytechnic University Shenzhen Research Institute, Shenzhen, China Key Laboratory for Environment and Health, Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College Huazhong University of Science and Technology Wuhan China Tsinghua University Liaoning Ocean and Fisheries Science Research Institute and Dalian Key Laboratory of Genetic Resources for Marine Shellfish Dalian China Department of Plant Pathology Nanjing Agricultural University Nanjing China Department of Breast Surgery, Harbin Medical University, Harbin, China. State Key Laboratory of Optical Technologies on Nano‐Fabrication and Micro‐Engineering Institute of Optics and Electronics Chinese Academy of Sciences Chengdu 610209 China; Key Laboratory of Opto‐Electronic Technology and Systems of the Education Ministry of China Chongqing University Chongqing 400044 China Baylor College of Medicine Department of Molecular and Cellular Biology One Baylor Plaza Houston Texas USA Key Laboratory for Micro-Nano Optoelectronic Devices of Ministry of Education, and State Key Laboratory for Chemo/Biosensing and Chemometrics, Hunan University, Changsha 410082, China École Polytechnique Fédérale de Lausanne Global Health Institute Lausanne Switzerland National Engineering Research Center for Carbohydrate Synthesis, Jiangxi Normal University, Nanchang 330022, China; Beijing National Laboratory for Molecular Science (BNLMS), CAS Key Laboratory of Molecular Recognition and Function, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China Institute for Biomedical Research, Xiamen University, Xiamen, Fujian, 361005, People's Republic of China a Jockey Club Rehabilitation Engineering Center , Hong Kong Polytechnic University , Hung Hom, Kowloon, Hong Kong Department of Medical Imaging, First affiliated hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China Institute of Animal Genetics and Breeding, College of Animal Science and Technology, Sichuan Agricultural University, Chengdu 611130, China Department of Materials Science and Engineering and the Materials Research Center and Department of Chemistry, Northwestern University, Evanston, Illinois 60208 Key Laboratory of Qinghai‐Tibetan Plateau Animal Genetic Resource Reservation and Utilization, Sichuan Province and Ministry of Education Southwest Minzu University Chengdu China Department of Medical Imaging, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China Department of Health Technology Technical University of Denmark Kongens Lyngby DK‐2800 Denmark Department of Gastroenterology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China Guangdong Provincial Key Laboratory of Marine Biotechnology, Shantou University, Shantou, China; Marine Biology Institute, Shantou University, Shantou, China Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China. School of Chemistry and Chemical Engineering, Yangzhou University, Yangzhou, Jiangsu, 225002, China; Joint Laboratory of Yangzhou University and Kyushu Institute of Technology, Yangzhou University, Yangzhou, Jiangsu 225002, China College of Electrical Engineering, Anhui Polytechnic University, Wuhu, Anhui 241000, China Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Center for Excellence in Life and Paleoenvironment, Chinese Academy of Sciences, Beijing, China; University of Chinese Academy of Sciences, Beijing, China Inner Mongolia Key laboratory of Hypoxic Translational Medicine, Baotou Medical College, Inner Mongolia, P.R.C.; Beijing key laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, P.R.C. Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, No. 44 West Wenhua Road, Jinan 250012, China Department of Precision Machinery and Precision Instrumentation; University of Science and Technology of China; Hefei; China; Key Laboratory of Precision Scientific Instrumentation of Anhui Higher Education Institutes From the Krembil Research Institute (L.M.O., L.V.K.), Toronto Western Hospital, University Health Network, Ontario; Djavad Mowafaghian Centre for Brain Health (T.R.), Division of Neurology, Department of Medicine, University of British Columbia, Vancouver; Mark Feedman and Judy Jacobs Program for Gaucher Disease (G.A.M.N., D. Amato, L.V.K.), Mount Sinai Hospital; Fred A. Litwin Family Centre for Genetic Medicine (G.A.M.N., D.-L.N.), Department of Medicine, Mount Sinai Hospital and Toronto General... Department of Medical Oncology, Cancer Institute/Hospital, Peking Union Medical College & Chinese Academy of Medical Sciences; Beijing Key Laboratory of Clinical Study on Anticancer Molecular Target Drugs, Beijing 100021, China. Department of Otolaryngology, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye Ear Nose & Throat Hospital Fudan University Shanghai China School of Pharmacy, Shenyang Pharmaceutical University, Wenhua Road 103, Shenyang 110016, P. R. China Department of Gastroenterology, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China School of Petroleum Engineering, Xi’an Shiyou University, Xi’an 710065, China The Cleft Lip and Palate Treatment Center, Second Affiliated Hospital of Shantou University Medical College, Shantou 515041, China Department of Gastroenterology Drum Tower Hospital Nanjing University School of Medicine Nanjing China Anhui Province Key Laboratory of Agricultural Food Safety, College of Resources and Environment, Anhui Agricultural University, Hefei 230036, China. [email protected] Toronto General Research Institute 3 Division of Cellular and Molecular Biology, , 101 College Street, Toronto, Ontario M5G 1L7, Canada Department of Radiology, The Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University, Changzhou 213164, China Beijing Sport University, Beijing, China Shanghai Key Laboratory of New Drug Design, State Key Laboratory of Bioreactor Engineering, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China Department of Endocrinology, The Central Hospital of Enshi Tujia and Miao Autonomous Prefecture, Enshi, Hubei 445000, P.R. China Jiangsu Collaborative Innovation Center for Biological Functional Materials, College of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Engineering Researche, Center for Biomedical Function Materials, Nanjing 210023, China; Department of Biological Sciences, Florida International University, Miami, Florida 33199, United states Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania. School of Optoelectronic Science and Engineering; University of Electronic Science and Technology of China (UESTC); Chengdu; P. R. China Guangdong Provincial Key Laboratory of Marine Biology, Institute of Marine Sciences, Shantou University, Shantou, China Department of Orthopedic Surgery, The Second Peoples’ Hospital of Huai’an, Xuzhou Medical University, Huai’an, Jiangsu, China (mainland) Department of Cardiology, Second Affiliated Hospital of Xi’an Medical University, Xi’an, Shaanxi, China (mainland) Department of Oncology, Sidney Kimmel Comprehensive Cancer Center Johns Hopkins Medical Institutions Baltimore MD USA Department of Urology, Affiliated Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China (mainland) School of Bioengineering, Dalian University of Technology, 2 Linggong Road, Hi-tech Zone, Dalian 116024, China Department of Neurosurgery, Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710004, China Department of Orthopaedic Surgery, Nanjing First Hospital, Nanjing Medical University , Nanjing 210006, China Department of Urology, Renji Hospital Shanghai Jiaotong University School of Medicine Shanghai China State Key Laboratory of Supramolecular Structure and Materials; College of Chemistry; Jilin University; Changchun; P. R. China Department of Cardiovascular Medicine The Second Hospital of Jilin University Jilin China Dementia Care and Research Center, Clinical Research Division, Peking University Institute of Mental Health, Sixth Hospital, Haidian District, Beijing, China; Beijing Dementia Key Lab, National Clinical Research Center for Mental Disorders, Key Laboratory of Mental Health, Ministry of Health, Peking University, Beijing, China; Department of Psychiatry, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China Cardiology Department Beijing An Zhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung and Blood Vessel Diseases Beijing China Imaging Center, First Hospital of Xi'an Jiaotong University Medical School, Xi'an 710061, China. Department of Medical Imaging, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, People’s Republic of China Department of Pharmacology, College of Basic Medical Sciences, School of Nursing, Jilin University, Changchun, China; Department of Pharmacology and Therapeutics, Center for Research and Treatment of Atherosclerosis, University of Manitoba, Winnipeg, Manitoba, Canada; DREAM Children’s Hospital Research Institute of Manitoba, Winnipeg, Manitoba, Canada Department of Orthopaedics, The Affiliated Huai’an Hospital of Xuzhou Medical University, The Second People’s Hospital of Huai’an, Huai’an, Jiangsu, China (mainland) [email protected] Hainan Provincial Key Laboratory of Tropical Medicine, Hainan Medical College, Haikou, China Department of Orthopedics, Zhongda Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210009, China Department of Gastroenterology, Affiliated Drum Tower Hospital, Medical School, Nanjing University, Nanjing 210008, China Department of Entomology Nanjing Agricultural University Nanjing China Department of Medical Genetics Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College Kunming PR China; Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious Disease Institute of Medical Biology, Chinese Academy of Medical Sciences Kunming PR China State Key Laboratory of Advanced Electromagnetic Technology, School of Electrical Engineering and Electronics, Huazhong University of Science and Technology, Wuhan 430074, China Department of Chemistry The University of Hong Kong Pokfulam Hong Kong P.R. China Department of Neurosurgery, The Second Affiliated Hospital of Xi’an Jiaotong University, No. 157 of Xiwu Road, Xi’an, Shaanxi 710004, China Institute of Microbial Chemistry (BIKAKEN), Tokyo Department of Physiology, Temple University School of Medicine, Philadelphia, Pennsylvania, USA; Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, Pennsylvania, USA The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD, USA Department of Ultrasonography, The Second Xiangya Hospital; Central South University; No.139 Middle Renmin Road Changsha Hunan 410011 China 1 Abteilung Bioinformatik, Institut für Mikrobiologie und Genetik, Georg-August-Universität Göttingen, Goldschmidtstrasse 1, 37077 Göttingen, Germany, 2 Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM 87545 and 3 The Santa Fe Institute, Santa Fe, NM 87501, USA Authors' Affiliations: 1Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering, China Agricultural University; Department of 2Food Science and 3Peking University Cancer Hospital, School of Oncology, Peking University, Beijing, China; and Department of 4Animal Science, Cornell University, Ithaca, New York Department of Radiology, The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University, Changzhou, China. Department of Laboratory Medicine, Med‐X Center for Manufacturing West China Hospital, Sichuan University Chengdu China Department of Biostatistics and Epidemiology, School of Public Health Shenzhen University Medical School Shenzhen Guangdong People's Republic of China Nephropathy, Huashan Hospital, Fudan University, Shanghai, P.R. China. School of Food Science and Chemical Engineering, Beijing Technology and Business University, Beijing, China Department of Polymer Science and Engineering School of Chemistry and Chemical Engineering Shanghai Jiao Tong University Shanghai 200240 China Department of Biochemistry, University of Lausanne, 1066 Epalinges, Switzerland; Department of Physics and Astronomy and Collaborative Innovation Center of IFSA (CICIFSA) Shanghai Jiao Tong University Shanghai 200240 China Department of Epidemiology and Health Statistics, Shenzhen University Health Science Center, Shenzhen, Guangdong, China Department of Human Anatomy, Baotou Medical College, Inner Mongolia, China Natural Antibodies, Inc., Boston, MA 02115; and Departments of Pathology, Surgery, and Pediatrics, Harvard Medical School, CBR Institute for Biomedical Research, Brigham and Women's Hospital, and Massachusetts General Hospital, Boston, MA 02115 State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology 100029 Beijing China Hangzhou Environmental Monitoring Central Station, Hangzhou 310007, China. College of Chemistry, Jilin University, Changchun, 130023, People's Republic of China Department of Endocrinology Xuzhou Third People's Hospital Xuzhou Jiangsu China Center for Community Health Management, The Affiliated Luohu Hospital of Shenzhen University Health Science Center Shenzhen Guangdong China; School of Public Health Shenzhen University Health Science Center Shenzhen Guangdong China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules Center of Hydrogen Science Shanghai Key Lab of Electrical Insulation & Thermal Aging Shanghai Jiao Tong University Shanghai 200240 P. R. China Nanjing Center, China Geological Survey, Nanjing 210016, China School of Computer Science and Technology, China University of Mining and Technology, Xuzhou, Jiangsu 21116, China Department of Otolaryngology, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai, China Department of Preventive Medicine Shenzhen University Health Science Center Shenzhen People's Republic of China Center of Reproductive Medicine, Zhongnan Hospital of Wuhan University, Wuhan, P. R. China State Key Laboratory and Institute of Elemento-Organic Chemistry, Haihe Laboratory of Sustainable Chemical Transformations, Frontiers Science Center for New Organic Matter, College of Chemistry, Nankai University, Tianjin 300071, China Harvard Medical School, Boston, MA, U.S.A. College of Chemistry, Jilin University, Changchun 130023, P.R. China Center for Pulmonary and Infectious Disease Control,2 Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, Xuzhou 221004, China; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, Xuzhou Medical University, Xuzhou 221004, China; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou 221004, China Jiangsu Forest Resources Inspect Center, Nanjing, PR China Jiangsu Key Laboratory of Advanced Catalytic Materials and Technology; Advanced Catalysis & Green Manufacturing Collaborative Innovation Center; School of Petrochemical Engineering; Changzhou University; Changzhou Department of Medical Imaging, First Affiliated Hospital of Xi’an, Jiaotong University, Xi’an, China Department of Integrated Traditional Chinese Medicine and Western Medicine, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, P.R. China Shaanxi Key Laboratory of Advanced Stimulation Technology for Oil & Gas Reservoirs, Xi'an Shiyou University, China First Affiliated Hospital of School of Medicine, Xi’an Jiaotong University, Xi’an, 710061, China Department of Neurobiology and Collaborative Innovation Center for Brain Science School of Basic Medicine Fourth Military Medical University Xi'an China Department of Emergency, the Second Affiliated Hospital of Xi'an Jiao Tong University, Xi'an, China Department of Vascular Surgery, The Affiliated Drum Tower Hospital, Nanjing University Medical School, Nanjing 210008, China Institute of Microbial Chemistry (BIKAKEN) 3-14-23 Kamiosaki, Shinagawa-ku Tokyo 141-0021 Japan), Fax: (+81) 3-3441-7589 Institute of Neurosciences, The Fourth Military Medical University, Xi’an 710032, China Department of Medical Imaging First Affiliated Hospital of Xi'an Jiaotong University Xi'an Peoples Republic of China School of Basic Medical Sciences, Guizhou Medical University, Guiyang 550004, China; The Key Laboratory of Chemistry for Natural Products of Guizhou Province, Chinese Academy of Sciences, Guiyang 550014, China College of Agriculture Northeast Agricultural University Harbin 150030 China; Heilongjiang Academy of Agricultural Sciences Industrial Crop Institute Harbin 150086 China 1Reproductive Medicine Center, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, People’s Republic of China; 2Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health, Wuhan, Hubei, People’s Republic of China Jiangsu Key Laboratory of Infection and Immunity, Institutes of Biology and Medical Sciences, Soochow University, Suzhou, P R China The State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Weijin Road 94#, Nankai District, Tianjin, P. R. China The Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York 14214, United States; New York State Center of Excellence in Bioinformatics and Life Sciences, Buffalo, New York 14203, United States Max Planck Institute for Polymer Research, Ackermannweg 10, D-55128 Mainz, Germany Department of Neurology, The Second Affiliated Hospital of Nanchang University, Nanchang, China Department of Ultrasound Diagnosis, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China State Key Laboratory of Cellular Stress Biology Innovation Center for Cell Signaling, Network School of Life Sciences Xiamen University 361101 Fujian China; State‐Province Joint Engineering Laboratory of Targeted Drugs from Natural Products School of Life Sciences Xiamen University 361101 Fujian China Key Laboratory for Supramolecular Structure and Materials, Jilin University, Changchun 130012, PRC Department of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine, Fourth Military Medical University, Xi'an, China Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen University Health Science Center, Shenzhen, Guangdong, China Tianjin Centers for Disears Control and Prevention, Tianjin 300011, China. Department of Preventive Medicine, Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China; The Affiliated Luohu Hospital of Shenzhen University Health Sciences Center, Shenzhen, Guangdong, People's Republic of China From the Department of Biochemistry and Molecular Biology, Key Laboratory of Neural and Vascular Biology, Ministry of Education (X.-h.Z., B.Z., Z.Y., M.H., L.-y.Y., R.-n.Z., J.-k.W.) and Department of Pharmacology, Institute of Chinese Integrative Medicine (M.Z., W.Z., X.Z.), Hebei Medical University, Shijiazhuang, China. Department of Stomatology, Hainan Branch of Chinese People's Liberation Army General Hospital, Sanya, Hainan 572013, P.R. China Department of Medical Imaging, First Affiliated Hospital of Xi'an Jiaotong University Xi'an China Department of Stomatology, Chinese PLA General Hospital, Beijing 100853, China. College of Resources and Environmental Sciences, Gansu Agricultural University, Lanzhou 730070, China. b School of Architecture and Civil Engineering, Anhui Polytechnic University, Wuhu 241000, China From the Department of Laboratory Medicine and Pathobiology (S.M., D.D., B.L.L.), University of Toronto, Canada; Toronto General Research Institute (S.M., D.D., F.X., M.Z., B.L.L.), University Health Network, Canada; and Department of Anatomy and Cell Biology (M.R.J.), College of Medicine, University of Florida, Gainesville. Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong, People's Republic of China. National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341 Division of Cell and Molecular Biology, Toronto General Research Institute, University Health Network, Toronto, ON M5G 2C4, Canada Qingdao Stomatological Hospital, Qingdao, Shandong 266000, P.R. China Department of Pathology, Peking University International Hospital, Beijing 102206, China Radiology Department, the Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University, Changzhou 213164, Jiangsu, China Department of Civil and Environmental Engineering, University of California at Los Angeles, Box 951593, Los Angeles, California 90095-1593, United States Geological Survey of Japan, National Institute of Advanced Industrial Science and Technology (AIST) Department of Gout, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai. [email protected] 3Department of Molecular Pharmacology and Biological Chemistry and Robert H. Lurie Cancer Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois Department of Thyroid and Breast Surgery Pingluo People’s Hospital Ningxia China; Department of Thyroid and Parathyroid Surgery West China Hospital Sichuan University Chengdu China Department of Pathology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College Beijing China; Department of Pathology Haidian Meternal & Children Health Hospital Beijing China Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341 Institute for Energy Research, Jiangsu University, Zhenjiang 212013, China Key Laboratory of New Membrane Materials, Ministry of Industry and Information Technology, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, China Division of Rheumatology, Tufts Medical Center, 800 Washington Street, Box No. 406, Boston, MA 02111, USA College of Materials Science and Engineering, Yanshan University, 066004, Qinhuangdao, People's Republic of China Molecular Medicine Research Center and Department of Ophthalmology, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan 610064, China; Theoretical Biology Group, Los Alamos National Laboratory, Los Alamos, NM 87544, USA. Department of Orthopaedics and Rehabilitation, Center for Musculoskeletal Research, University of Rochester School of Medicine, Rochester, NY 14642, USA Department of Materials Engineering, College of Materials and Textile, Zhejiang Sci-Tech University, Hangzhou 310018, People’s Republic of China; Key Laboratory of Advanced Textile Materials and Manufacturing Technology of the Ministry of Education, Zhejiang Sci-Tech University, Hangzhou 310018, People’s Republic of China Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, GA, USA Department of Neurosurgery The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an China 1CBR Institute for Biomedical Research, Inc.; 2Department of Pathology; 7DecImmune Therapeutics, Boston, MA 02115 Department of Cell Biology, Cleveland Clinic Foundation, Cleveland, OH, USA Laboratory of Forest Ecology and Global Changes, School of Life Science, Nanjing University, Nanjing 210093, China. [email protected] Authors' Affiliation: Department of Radiation Oncology, University of Michigan School of Medicine, Ann Arbor, Michigan Department of Medical Imaging, First Affiliated Hospital of Xi'an Jiaotong University College of Medicine, Xi'an, Shan'Xi, China Central Laboratory, General Hospital of Chengdu Military Command, Chengdu 610083, China. [email protected]. Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, The Airforce Medical University of People's Liberation Army of China, Xi'an 710032, China. Molecular and Cell Biology Baylor College of Medicine Houston Texas USA Bengbu Medical College Key Laboratory of Cardiovascular and Cerebrovascular Diseases, Longzihu, Bengbu 233030, Anhui, P.R. China b School of Chemical and Environmental Engineering, Anhui Polytechnic University, Wuhu 241000, China Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen University Health Science Center , Shenzhen, 518000, Guangdong , China Department of Gastroenterology, Affiliated Drum Tower Hospital of Nanjing University Medical School Senior Department of Otolaryngology-Head and Neck Surgery, The Sixth Medical Center of PLA General Hospital, Beijing, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing, China; State Key Laboratory of Hearing and Balance Science, Beijing, China Department of Burns and Plastic Surgery Fourth Medical Center of Chinese PLA General Hospital, (PLA:People's Liberation Army) Beijing China State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, P. R China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, P. R. China Department of Hepatobiliary Surgery Shandong Provincial Third Hospital Jinan China Department of Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, China. Department of Biostatistics and Applied Mathematics, The University of Texas, M.D. Anderson Cancer Center, Houston, Texas, USA. Frontiers Science Center for Transformative Molecules and In Situ Center for Physical Science, School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China Department of Otorhinolaryngology Head and Neck Surgery, Eye and ENT Hospital, Fudan University, Shanghai, China; Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, China Department of Intensive Care Unit, Qingyuan People's Hospital,Qingyuan,China Reproductive Medicine Center Zhongnan Hospital of Wuhan University Wuhan China; Hubei Clinical Research Center for Prenatal Diagnosis and Birth Health Wuhan China Department of Oncology, Hebei General Hospital, Shijiazhuang 050017, China. School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules Shanghai Jiao Tong University Shanghai 200240 P. R. China Department of Pathology, Yantai Yantaishan Hospital Yantai, Shandong, China. First Rehabilitation Hospital, School of Medicine, Tongji University, Shanghai, China; Collaborative Innovation Center for Brain Science, Tongji University, Shanghai, China; Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, 60 Leonard Ave, Toronto, ON, Canada Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu, China Department of Liver Surgery and Liver Transplantation Center, West China Hospital of Sichuan University, Chengdu, P.R. China. More Medicines for Tuberculosis (MM4TB) Consortium www.mm4tb.org; Global Health Institute Ecole Polytechnique Fédérale de Lausanne Lausanne Switzerland The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), No. 36, Mingxin Road, Guangzhou 510370, China School of EECS, Peking University , Beijing, China ENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital Fudan University Shanghai China Department of Urology, The Second Hospital of Hebei Medical University, Shijiazhuang, P.R. China State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Qianjin Avenue 2699, Changchun 130012, P.R. China Jiangsu Nongken Malt Company Limited Yancheng Peoples Republic of China Department of Laboratory Medicine; State Key Laboratory of Biotherapy and Cancer Center; West China Hospital; Sichuan University and Collaborative Innovation Center for Biotherapy; Chengdu Hepatobiliary Surgery Department, Shandong Provincial Third Hospital, Jinan, Shandong, China Senior Department of Otolaryngology-Head and Neck Surgery, the Sixth Medical Center of PLA General Hospital, Beijing, China; National Clinical Research Center for Otolaryngologic Diseases, Beijing, China; State Key Laboratory of Hearing and Balance Science, Beijing, China Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia; Department of Pathology Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, China Center for Substance Abuse Research, Temple University School of Medicine, Philadelphia, Pennsylvania. Department of Otorhinolaryngology, Eye & ENT Hospital, Fudan University, Shanghai, China Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, China Department of Medical Imaging, First Affiliated Hospital of Medical College of Xi’an Jiaotong University, Xi’an 710061, China Department of Nephrology, Huashan Hospital, Fudan University, Shanghai 200040, China. Department of Vascular Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, China Department of Radiation Oncology, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan, Kunming, Yunnan 650118, P.R. China College of Food Science and Engineering, Hainan University, 58 Renmin Road, Haikou 570228, China Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, Chicago, Illinois 60611, United States Department of Oral and Maxillofacial Surgery, Hospital of Stomatology, Guanghua School of Stomatology Sun Yat‐sen University Guangzhou China Department of Cardiology, Xi'an Jiaotong University College of Medicine, Xi'an, China. [email protected] Department of Pathology Peking University School of Basic Medical Science Peking University Third Hospital Peking Univeristy Health Science Center Beijing China Interdisciplinary Division of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, China. Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou, Jiangsu 215123, P. R. China; School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China (UESTC), Chengdu, Sichuan 610054, P. R. China Los Alamos National Laboratory, Los Alamos, New Mexico 87545 Department of Critical Care Medicine Affiliated Hospital of Weifang Medical University Weifang Shandong China Geological Survey of Japan National Institute of Advanced Industrial Science and Technology (AIST) Tsukuba 305‐8567 Japan Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong 999077, P.R.China. Interdisciplinary Division of Biomedical Engineering, Faculty of Engineering, The Hong Kong Polytechnic University, Hong Kong, China; Shenzhen Research Institute, The Hong Kong Polytechnic University, Shenzhen, China Institute of Microbial Chemistry (BIKAKEN), Tokyo 3-14-23 Kamiosaki, Shinagawa-ku Tokyo 141-0021 Japan Department of pathology, Pennsylvania Hospital University of Pennsylvania Health System Philadelphia Pennsylvania College of Animal Science & Technology, Sichuan Agricultural University, Ya'an, People's Republic of China. The University of Chicago Department of Physics, , Chicago, Illinois 60637, USA; Department of Chemistry, , Chicago, Illinois 60637, USA; and The James Franck Institute, , Chicago, Illinois 60637, USA; The University of Chicago Department of Physics, , Chicago, Illinois 60637, USA; Department of Chemistry, , Chicago, Illinois 60637, USA; and The James Franck Institute, , Chicago, Illinois 60637, USA; The University of Chicago Department of Physics, , Chicago, Illinois 60637, USA; Department of Chemistry, , Chicago, Illinois 60637, USA; and The James Franck Institute, , Chicago, Illinois 60637, USA Center for Reproductive Medicine, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, P.R. China; Clinical Medicine Research Center of Prenatal Diagnosis and Birth Health in Hubei Province, Wuhan, Hubei, P.R. China Department of Gastroenterology, Affiliated Drum Tower Hospital of Nanjing University, Medical School, Nanjing, People’s Republic of China Department of Intensive Care Unit, The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People’s Hospital, Qingyuan, China Danish Institute for Advanced Study and Department of Physics, Chemistry and Pharmacy University of Southern Denmark Odense 5230 Denmark; Jiangsu Collaborative Innovation Center of Biomedical Functional Materials Jiangsu Key Laboratory of Bio-functional Materials School of Chemistry and Materials Science Nanjing Normal University Nanjing 210023 China; Department of Biological Sciences Florida International University Miami FL 33199 USA Key Lab. of Food Nutrition and Safety, Ministry of Education, College of Food Engineering and Biotechnology Tianjin Univ. of Science and Technology Tianjin 300457 China Department of Respiratory, The First Hospital of Jiaxing, Affiliated Hospital of Jiaxing University Institute of Biopharmaceutical Research, Liaocheng University, Liaocheng 252059, P. R. China Tianjin Centers for Disease Control and Prevention, Tianjin, People’s Republic of China Department of Anatomy and Structural Biology, University of Otago, Dunedin, New Zealand Department of Thoracic and Cardiovascular Surgery, Changzhou No. 2 People's Hospital, Nanjing Medical University, Changzhou, Jiangsu 213003, China Department of Epidemiology and Biostatistics, Tongji Medical College Huazhong University of Science and Technology Wuhan China Tianjing Center for Disease Control and Prevention, Tianjing, China Laboratory of Nutritional Immunology and Translational Medicine, State Key Laboratory of Food Science and Technology Jiangnan University Wuxi China; School of Food Science and Technology Jiangnan University Wuxi China Department of Materials Engineering; College of Materials and Textile; Zhejiang Sci-Tech University; Hangzhou 310018; P. R. China Xinyang Agricultural Experiment Station of Yancheng City Yancheng China Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University, Augusta, Georgia Department of Ophthalmology, West China Hospital, Sichuan University Department of the Thyroid and Breast Surgery, Longyan First Hospital Affiliated to Fujian Medical University , No. 105 Jiuyi North Road, Xinluo District, Longyan City, FJ 364000 , China Amgen, Inc. Thousand Oaks California Department of Epidemiology, School of Public Health Shenzhen University Health Science Center Shenzhen Guangdong PR China *CBR Institute of Biomedical Research,; †Department of Pathology, Department of Radiation Oncology, The Third Affiliated Hospital of Kunming Medical University, Tumor Hospital of Yunnan Province, Kunming, P.R. China Department of Thoracic and Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China; and Inorganic Toxicology and Nutrition Branch, Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA Key Lab of Ion Beam Bioengineering, Institute of Plasma Physics, the Chinese Academy of Sciences, Hefei, China. Department of Hand Surgery, Wuhan Fourth Hospital; Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430033, China Department of Orthopedics Shandong Qianfoshan Hospital Shandong University Shandong China College of Life Sciences Zhejiang University Hangzhou China Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan, China; Department of General Surgery, Mianzhu Hospital of West China Hospital, Sichuan University, Mianzhu 618200, Sichuan, China Department of Spinal Surgery, Zaozhuang Municipal Hospital, Zaozhuang, Shandong 277101, P.R. China 1Department of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China. Department of Epidemiology, School of Public Health, Shenzhen University Health Science Center From the *Department of Clinical Pharmacy, and †Institution of National Drug Clinical Trials, The Affiliated Brain Hospital, Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China. College of Pharmacy, Academy of Integrative Medicine; The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease; Dalian Medical University; Dalian 116044; China 11.Department of Neurosurgery, Henan Provincial People’s Hospital, Zhengzhou University People’s Hospital, Zhengzhou, Henan, China Peking University, Beijing, IL, China Department of Epidemiology and Health Statistics School of Public Health, Shenzhen University Health Science Center Shenzhen People's Republic of China School of Public Health, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China; Study Team of Shenzhen’s Sanming Project, The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China Department of Breast and Thyroid Surgery, Jilin Central General Hospital, Chuanying, Jilin 132000, P.R. China Department of Thoracic and Cardiovascular Surgery Changzhou No. 2 People's Hospital Affiliated to Nanjing Medical University Changzhou Jiangsu 213003 China Hainan University-HSF/LWL Collaborative Innovation Laboratory, School of Food Science and Engineering, Hainan University, Haikou 570228, China Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders, Guangzhou, China; Department of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou, China Department of Respiratory and Critical Care Medicine The Third Affiliated Hospital of Soochow University Changzhou China Ophthalmology Department The First Affiliated Hospital of Xi’an Jiaotong University Xi’an China Centre de Nanosciences et de Nanotechnologies, CNRS UMR‐9001, Univ. Paris Sud Université Paris‐Saclay C2N France Department of Anatomy, University of Otago; and Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine , College of Veterinary Medicine , Harbin 150030 , China Department of Prevention Medicine Shenzhen University School of Medicine Shenzhen China College of Life Sciences, Central China Normal University, Wuhan 430079, China. Department of Physiology, University of Toronto, Ontario, Canada Guangdong Cardiovascular Institute//Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China. Department of Respiratory, The First Hospital of Jiaxing (The Affiliated Hospital of Jiaxing University), Jiaxing, Zhejiang PR China Division of Cardiovascular Diseases, Mayo Clinic, Rochester, MN Department of Epidemiology and Health Statistics, Shenzhen University Health Science Center, Shenzhen, Guangdong, People’s Republic of China Department of Urology & Andrology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200001, China Tianjin Centers for Disease Control and Prevention, Tianjin, China *Center for Pulmonary and Infectious Disease Control, and Departments of Department of Chemistry and James Franck Institute, University of Chicago, Chicago, Illinois 60637, and Chemical Sciences and Engineering Division, Argonne National Laboratory, Argonne, Illinois 60439 Institution of National Drug Clinical Trials, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China School of Physics, Inner Mongolia University of Science and Technology, Baotou 014010, P. R. China. Laboratory of Thyroid and Parathyroid Disease Department of Thyroid and Parathyroid Surgery Frontiers Science Center for Disease‐Related Molecular Network West China Hospital Sichuan University Chengdu China; Department of Thyroid and Breast Surgery Pingluo People's Hospital Ningxia China Radiology Department, Affiliated Hospital 2 of Nantong University, Nantong First People’s Hospital, NanTong, Jiangsu, China Department of Gastroenterology Affiliated Drum Tower Hospital of Nanjing University Medical School 321# Zhongshan Road Nanjing 210008 Jiangsu China Department of Urology, Second Hospital of Hebei Medical University, Shijiazhuang, Hebie, China Institute of Neuroscience, Fourth Military Medical University, Xi'an, People's Republic of China; Department of Urology. Department of Natural Product Chemistry, Key Lab of Chemical Biology of Ministry of Education, School of Pharmaceutical Sciences, Shandong University, 44 Wenhua West Road, Jinan 250012, People’s Republic of China ENT Institute and Department of Otorhinolaryngology Eye & ENT Hospital, Fudan University Shanghai China School of Optoelectronic Science and Engineering University of Electronic Science and Technology of China (UESTC) Chengdu 610054 P. R. China Department of Psychology Soochow University Suzhou China; Research Center for Psychology and Behavioral Sciences Soochow University Suzhou China Department of Ultrasound the 2nd Xiangya Hospital of Central South University Hunan China Department of Nephrology, Huashan Hospital, Fudan University , Shanghai , China Department of Otorhinolaryngology-Head and Neck Surgery, Eye Ear Nose and Throat Hospital of Fudan University, Shanghai, China; State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, China; Département de Chimie, Université de Montréal, C.P. 6128, Succursale Centre-ville, Montréal, QC H3C 3J7, Canada Institute of Medical Biology Chinese Academy of Medical Sciences, and Peking Union Medical College Kunming People's Republic of China; Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious Disease Kunming People's Republic of China Heilongjiang Academy of Agricultural Sciences Postdoctoral Programme, Institute of Industrial Crops, Heilongjiang Academy of Agricultural Sciences, Harbin 150086, China The Institute of Genetics, College of life sciences, Zhejiang University, Hangzhou, China. Department of Materials Engineering, College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, China State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China Department of Radiology, First Affiliated Hospital of Xi’an Jiaotong University Jiangsu Key Laboratory of Chemical Pollution Control and Resources Reuse, School of Environmental and Biological Engineering, Nanjing University of Science and Technology, Nanjing 210094, People’s Republic of China Department of General Surgery and Department of Biostatistics and Epidemiology, School of Public Health Shenzhen University Shenzhen China Company 13, Student Brigade, Fourth Military Medical University, Xi'an 710032, China. Key Laboratory for Supramolecular Structure and Materials of Ministry of Education, Jilin University, Changchun 130012, PR China National and Local Joint Engineering Research Center of Biomedical Functional Materials School of Chemistry and Materials Science Nanjing Normal University Nanjing 210023 China College of Environment Zhejiang University of Technology Hangzhou People's Republic of China Institute of Burn Research, Southwest Hospital, State Key Laboratory of Trauma, Burns and Combimed injury, the Third Military Medical University, Chonqing 400038, PR China. Guangzhou Beile Food Co., Ltd Guangzhou China Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China Dalian Key Laboratory of Genetic Resources for Marine Shellfish, Liaoning Ocean and Fisheries Science Research Institute , Dalian 116023, China Department of Gastroenterology, Zhongnan Hospital, Wuhan University , Wuhan, PR China School of Minerals Processing and Bioengineering, Central South University, Changsha, China; Key Laboratory of Biometallurgy of Ministry of Education, Central South University, Changsha, China College of Agriculture Northeast Agricultural University Harbin 150030 China; National Key Facility for Crop Gene Resources and Genetic Improvement Institute of Crop Science, Chinese Academy of Agricultural Sciences Beijing 100081 China; Industrial Crop Institute Heilongjiang Academy of Agricultural Sciences Harbin 150086 China Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences University at Buffalo, State University of New York Buffalo NY 14214; New York State Center of Excellence in Bioinformatics and Life Sciences Buffalo NY 14203 Department of Pharmaceutical Sciences, University at Buffalo, Buffalo, NY 14214, USA; New York State Center of Excellence in Bioinformatics and Life Sciences, Buffalo, NY 14203, USA Institute of Genetics, College of Life Sciences, Zhejiang University, Hangzhou, China. Department of Orthopedics, Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi 545005, P.R. China Department of Obstetrics and Gynecology, Fourth Military Medical University, Xi'an 710032, China. School of Chemistry and Chemical Engineering, Frontiers Science Center for Transformative Molecules, Center of Hydrogen Science, Shanghai Key Lab of Electrical Insulation & Thermal Aging, Shanghai Jiao Tong University, Shanghai 200240, China School of Resources and Environment Engineering, Wuhan University of Technology, Wuhan 430070, People's Republic of China Department of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital), Guangzhou, China. College of Materials Science and Engineering, Key Laboratory for Micro−Nano Optoelectronic Devices of Ministry of Education, and State Key Laboratory for Chemo/Biosensing and Chemometrics, Hunan University, Changsha 410082, People’s Republic of China The Fifth Psychiatric Department, and College of Agricultural and Biological Engineering (College of Tree Peony), Heze University, Heze, China Hospital of Stomatology Sun Yat‐sen University Guangzhou China; Guangdong Provincial Key Laboratory of Stomatology Guangzhou China; Guanghua School of Stomatology Sun Yat‐sen University Guangzhou China Department of Radiation Oncology, Hebei General Hospital, Shijiazhuang Department of Vascular Surgery, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu, China (mainland) Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan 48109, USA. [email protected] School of Food and Chemical Engineering Beijing Technology and Business University Beijing 100048 China Department of Thoracic Surgery, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China. Institute of Medical Biology, Chinese Academy of Medical Sciences, Peking Union Medical College Kunming People's Republic of China; Yunnan Key Laboratory of Vaccine Research Development on Severe Infectious Disease Kunming People's Republic of China *State Key Laboratory of Agrobiotechnology, College of Biological Sciences, National Engineering Laboratory for Animal Breeding, China Agricultural University, Beijing 100193, People’s Republic of China; State Key Laboratory for Mesoscopic Physics and Collaborative Innovation Center of Quantum Matter, School of Physics, Peking University, Beijing 100871, China Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, China. Key Laboratory of Fundamental Science for National Defense-Advanced Design Technology of Flight Vehicle, Nanjing University of Aeronautics & Astronautics, Nanjing, China Department of Neonatology, Shandong Provincial Maternal and Child Health Care Hospital Affiliated to Qingdao University, Jinan, China. Gaochun District Water Authority Bereau, Nanjing 211300, China. Laboratory of Molecular Medicines, Medical College, Nankai University, Tianjin 300071, China. Department of Oncology, Sichuan Provincial People's Hospital, Sichuan Academy of Medical Sciences, School of Clinical Medicine of University of Electronic Science and Technology of China, Chengdu, Sichuan 610000, P.R. China State Key Laboratory of Plant Physiology and Biochemistry College of Biological Sciences China Agricultural University Beijing 100094 China College of Chemistry and Chemical Engineering and Key Laboratory of Functional Small Organic Molecule, Ministry of Education, Jiangxi Normal University (Yaohu Campus) IMPACT Therapeutics Inc. Shanghai China The Sixth Affiliated Hospital of Guangzhou Medical University, Qingyuan People's Hospital Qingyuan China Department of Orthopedics Trauma Puren Hospital, Wuhan University of Science and Technology Wuhan P.R. China Department of Pharmacology, College of Basic MedicineJilin UniversityChangchunJilinChina Department of Radiation Oncology, University of Michigan Medical School, Ann Arbor, Michigan Department of Pharmacology; Nanomedicine Engineering Laboratory of Jilin Province; College of Basic Medical Sciences; Jilin University; Changchun 130021 School of Food Science and Engineering; Qilu University of Technology; Shandong Academy of Sciences; Jinan 250353; China Institute of Materials, China Academy of Engineering Physics, Jiangyou 621908, Sichuan, People's Republic of China State Key Laboratory of Coking Coal Resources Development and Comprehensive Utilization, Pingdingshan 467002, China Department of General Surgery, Fengxian Central Hospital, Shanghai Jiao Tong University, Shanghai, China. Department of Oral and Maxillofacial Surgery Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat‐sen University Guangzhou China; Guangdong Provincial Key Laboratory of Stomatology Sun Yat‐sen University Guangzhou China Department of Ultrasonography, The Second Xiangya Hospital Central South University Changsha Hunan China IMPACT Therapeutics (Shanghai) Inc. Shanghai China Department of Radiology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, Shanxi, China; Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, CH-1015 Lausanne, Switzerland Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, China Department of Orthopedic Surgery, Lihuili Hospital of Ningbo Medical Center, Ningbo, Zhejiang, PR China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan Wuhan Institute of Physics and Mathematics, Chinese Academy of Sciences Wuhan China Key Laboratory of Drug Metabolism & Pharmacokinetics, China Pharmaceutical University School of Electrical & Electronic Engineering, Tianjin Key Laboratory of Film Electronic & Communication Devices, Tianjin University of Technology, Tianjin 300384, China Lynn Institute for Healthcare Research and Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences, Jilin University, Changchun 130021, China Department of Biostatistics and Epidemiology School of Public Health Shenzhen University Health Science Center Shenzhen China Department of Obstetrics and Gynecology, Tianjin First Center Hospital, Tianjin 300192, China CAS Key Laboratory of Design and Assembly of Functional Nanostructures and Fujian Key Laboratory of Nanomaterials Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou 350002 P. R. China; Xiamen Key Laboratory of Rare Earth Photoelectric Functional Materials Xiamen Institute of Rare Earth Materials Haixi Institutes Chinese Academy of Sciences Xiamen 361021 P. R. China Department of Clinical Nutrition, Peking University Shenzhen Hospital Department of Urologic Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, 050000, China Department of Epidemiology and Biostatistics University of Georgia Athens Georgia USA Department of Psychology, Suzhou University of Science and Technology, Suzhou 215009, China; Faculty of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Okayama 700-0082, Japan Department of Oral and Maxillofacial Surgery, The Chinese People's Liberation Army General Hospital, Beijing, China. §Center for Pulmonary and Infectious Disease Control, University of Texas Health Center, Tyler, TX 75708; Beijing National Laboratory for Condensed Matter Physics and State Key Laboratory of Magnetism, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, P. R. China School of Architecture and Civil Engineering, Anhui Polytechnic University, Wuhu 241000, Anhui, P. R. China Department of Ultrasound Diagnosis, The Second Xiangya Hospital Central South University Changsha Hunan China Department of Neurosurgery, The Second Affiliated Hospital of Xi’an Jiaotong University, No. 157 Xiwu Road, Xi’an, Shaanxi 710004, China 1Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China. College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang 310058, People's Republic of China. Department of Laboratory Medicine, Changzhou Maternity and Child Health Hospital Affiliated to Nanjing Medical University, Changzhou, Jiangsu 213003, China School of Chemistry and Chemical Engineering, Yangzhou University, Jiangsu 225002, People’s Republic of China, Provincial Key Laboratories of Environmental Material and Engineering, Jiangsu 225002, People’s Republic of China, and Department of Polymer Science and Engineering, Shanghai Jiaotong University, Shanghai 200240, People’s Republic of China College of Science Zhejiang University of Technology Liuhe Rd 288 Xihu Hangzhou Zhejiang 310014 China Department of Burns and Plastic Surgery Fourth Medical Center of Chinese PLA General Hospital Beijing People's Republic of China Institute of Medical Science, The Second Hospital, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, China Department of Medical Imaging First Affiliated Hospital of Xi'an Jiaotong University Xi'an People's Republic of China Department of Epidemiology and Biostatistics University of Georgia Athens GA USA Department of Ophthalmology, West China Hospital, Sichuan University, China. Department of Medical Imaging The First Affiliated Hospital of Xi’an Jiaotong University Xi'an China Biomedicine Research Center and Basic Medical College, Baotou Medical College, Inner Mongolia, PRC; Inner Mongolia Key Laboratory of Hypoxic Translational Medicine, Baotou Medical College, Inner Mongolia, PRC; Beijing key laboratory of Hypoxic Conditioning Translational Medicine, Xuanwu Hospital, Capital Medical University, Beijing, PRC Department of Anesthesiology, State University of NewYork Downstate Medical Center, Brooklyn, NY 11203 ; Department of Cell Biology, State University of NewYork Downstate Medical Center, Brooklyn, NY 11203. Transplantation Center of Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Nanjing University, Nanjing 210023, P. R. China; Department of Environmental Engineering, College of Biology and the Environment, Nanjing Forestry University, Nanjing 210037, P. R. China Department of Psychology, Soochow University, Suzhou, China; Research Center for Psychology and Behavioral Sciences, Soochow University, Suzhou, China 2Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, Maryland. Department of Pediatric Orthopedic Surgery, Lianyungang No. 1 People's Hospital Affiliated to Xuzhou Medical University, Lianyungang, Jiangsu 222000, P.R. China Department of Bioinformatics and Computational Biology, The University of Texas M.D. Anderson Cancer Center, Houston, TX 77030, USA. Department of Pharmacology, School of Pharmacy, China Medical University, Shenyang, China Department of Urology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China; Transplantation Center of Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China Second Affiliated Hospital, Dalian Medical University, Dalian 116044, China; Dalian Key Laboratory of Metabolic Target Characterization and Traditional Chinese Medicine Intervention, College of Integrative Medicine, College of Pharmacy, Dalian Medical University, Dalian 116044, China Department of Pharmacy The Affiliated Brain Hospital of Guangzhou Medical University Guangzhou China; Guangdong Engineering Technology Research Center for Translational Medicine of Mental Disorders Guangzhou China Animal Reproduction Institute, Guangxi University, P. R. China Department of Environmental Engineering, College of Resources and Environmental Sciences, Nanjing Agricultural University, Nanjing 210095, China School of Chemistry and Chemical Engineering, Institute of Molecular Science, Shanxi University, Taiyuan 030006, China School of Life Sciences, Lanzhou University, Lanzhou 730000, China Artie McFerrin Department of Chemical Engineering, Materials Science and Engineering Program, Texas A&M University, 230 Jack E. Brown Engineering Building, 3122 TAMU, College Station, Texas 77843-3122, United States Tianjin Centers for Disease Control and Prevention, Tianjin 300011, China. China National Offshore Oil Corporation (CNOOC) Research Institute Limited Liability Company, Beijing 100027, China Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon‐Based Functional Materials & Devices Joint International Research Laboratory of Carbon‐Based Functional Materials and Devices Soochow University Suzhou Jiangsu 215123 P. R. China Postdocterial Station, Shao Yifu Hospital, Zhejiang University, Hanzhou, 310016, China Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York 14214, United States; New York State Center of Excellence in Bioinformatics and Life Sciences, Buffalo, New York 14203, United States Poultry Institute, Chinese Academy of Agricultural Sciences; Key Lab of Poultry Genetics and Breeding in Jiangsu Province Interdisciplinary Division of Biomedical Engineering, The Hong Kong Polytechnic University , Hong Kong, China. Swedish Heart and Vascular Institute, Seattle, WA, US School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu 610054, China Department of Pharmacology Jilin University Jilin China Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Hong Kong Laboratory for Nanophotonics, Rice University, Houston, Texas 77005, United States; Department of Physics and Astronomy, Rice University, Houston, Texas 77005, United States Institute of Functional Nano & Soft Materials (FUNSOM) and Jiangsu Key Laboratory for Carbon‐Based Functional Materials & Devices Soochow University Suzhou Jiangsu 215123 P. R. China; School of Optoelectronic Science and Engineering University of Electronic Science and Technology of China (UESTC) Chengdu Sichuan 610054 P. R. China The Department of Pharmaceutical Sciences, School of Pharmacy and Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York 14214, United States; New York State Center of Excellence in Bioinformatics and Life Sciences, Buffalo, New York 14203, United States Department of Automation, Faculty of Information Technology, Beijing University of Technology, Beijing100124, China; The Beijing International Collaboration Base on Brain Informatics and Wisdom Services, Beijing100024, China Hubei Key Laboratory of Genetic Regulation and Integrative Biology, School of Life Sciences, Central China Normal University, Wuhan 430079, People’s Republic of China Department of Liver Surgery Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai China Ningxia Medical University, Yinchuan 750000, China. Guangdong Provincial Key Laboratory of Microbial Culture Collection and Application, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China Key Laboratory for Micro‐Nano Optoelectronic Devices of Ministry of Education School of Physics and Electronics Hunan University Changsha 410082 China Department of Biomedical Engineering, The Hong Kong Polytechnic University, Kowloon, Hong Kong, SAR 999077, P.R. China Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou 215123, P.R. China; School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China (UESTC), Chengdu 610054, P.R. China Transplantation Center of Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China School of Psychology, Northeast Normal University, Changchun, P.R. China Department of Pharmacy, Ningbo Yinzhou NO.2 Hospital, Ningbo, China Department of Preventive Medicine Shenzhen University Health Science Center Shenzhen China Department of Otolaryngology, Eye Ear Nose Throat Hospital, Fudan University, Shanghai, 200031, China. Department of Physiology Michigan State University East Lansing Michigan; Neuroscience Program Michigan State University East Lansing Michigan; Institute of Molecular and Clinical Medicine Kunming Medical University Kunming China State Key Laboratory of Offshore Oil Exploitation, Beijing 100028, China; Tianjin Branch of CNOOC Ltd., Tianjin 300450, China Department of Cardiology, Hubei No.3 People's Hospital of Jianghan University Department of Clinical Laboratory, Changzhou Maternal and Child Health Care Hospital Affiliated to Nanjing Medical University, Changzhou, Jiangsu, China (mainland) School of Life Sciences Anhui Agricultural University Hefei Anhui China China Medical University, Liaoning, China From the School of Medicine (X.W., Y.Z., W.W., Z.L.), Departments of Cardiology (X.X., M.G., Z.W., Y.H.), and Intensive Care Unit (M.Z.), Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China. Institute of Cardiovascular Sciences, St. Boniface General Hospital Research Centre, and Department of Physiology, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba, Canada. Department of Radiology, First Affiliated Hospital of Xi’An Jiaotong University, Shaanxi Department of Orthopedics, Shandong Provincial Qianfoshan Hospital, Shandong University, Jinan, China Department of Internal Medicine, Liver Center, and Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta University, Augusta, Georgia, United States; James and Jean Vision Discovery Institute, Medical College of Georgia, Augusta University, Augusta, Georgia, United States Ecole Polytechnique Fédérale de Lausanne Global Health Institute Station 19 CH‐1015 Lausanne Switzerland Hospital of Stomatology Sun Yat‐sen University Guangzhou 510055 China; Guangdong Provincial Key Laboratory of Stomatology Guangzhou 510080 China; Guanghua School of Stomatology Sun Yat‐sen University Guangzhou 510055 China Department of Orthopedics, Fourth Affiliated Hospital of Guangxi Medical University, Liuzhou, Guangxi, China. College of Life Science, Capital Normal University, 100048 Beijing, China State Key Laboratory of Chemo/Biosensing and Chemometrics, School of Physics and Electronics, Hunan University, Changsha 410082, China School of Public Health Shenzhen University Health Science Center Shenzhen Guangdong P. R. China Huazhong University of Science and Technology State Key Laboratory of Advanced Electromagnetic Engineering and Technology, School of Electrical and Electronic Engineering, , Wuhan 430074, China Department of Pathology Memorial Sloan Kettering Cancer Center New York New York Email: [email protected]. Institute for Medical Imaging Technology, School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, China From the Department of Pathology, University of Washington, Seattle, Wash. *Department of Anesthesia, Critical Care and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114; Department of Anatomy and Structural Biology University of Otago Dunedin New Zealand Key Laboratory of Food Science and Technology Department of Food Science and Engineering Jiangnan University Wuxi 214122 China; School of Food Science and Technology Jiangnan University Wuxi 214122 China Department of Respiration Affiliated Hospital of Jiaxing University/The First Hospital of Jiaxing Jiaxing China 5Department of Radiation Oncology, Hebei General Hospital, Shijiazhuang, Hebei, China. Authors' Affiliations: Departments of 1Leukemia and 2Bioinformatics, The University of Texas M.D. Anderson Cancer Center, Houston, Texas; and 3Gemin X Pharmaceuticals, Malvern, Pennsylvania Department of Health Technology, Technical University of Denmark , Kongens Lyngby DK-2800, Denmark Department of Anesthesiology, College of Medicine, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA; Department of Cell Biology, College of Medicine, SUNY Downstate Medical Center, Brooklyn, NY 11203, USA Department of Pathology, School of Basic Medical Science, Peking University Health Science Center MOH Key Laboratory of Geriatrics, Beijing Hospital, National Center of Gerontology, Beijing, China; Graduate School of Peking Union Medical College, Beijing, China School of Chemistry and Chemical Engineering Frontiers Science Center for Transformative Molecules In‐situ Center for Physical Science and Center of Hydrogen Science Shanghai Jiao Tong University Shanghai 200240 P. R. China Department of Pharmacy The Affiliated Brain Hospital of Guangzhou Medical University (Guangzhou Huiai Hospital) Guangzhou China Department of Chinese Traditional Surgery, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China. [email protected] Department of Ultrasound The 2nd Xiangya Hospital of Central South University Changsha Hunan China From the Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts (M.Z., L.Z., Y.F., Y.-J.C., F.I., W.C.); and Department of Ultrasound Medicine, Second Xiangya Hospital, Xiangya School of Medicine, Changsha, China (M.Z., Q.Z.). Department of Rehabilitation Medicine, Xuzhou Central Hospital/The Xuzhou Clinical College of Xuzhou Medical University, Xuzhou, Jiangsu, China (mainland) Key Laboratory of Vertebrate Evolution and Human Origins, Institute of Vertebrate Paleontology and Paleoanthropology, Chinese Academy of Sciences, Beijing 100044, China.; Center for Excellence in Life and Paleoenvironment, Chinese Academy of Sciences, Beijing 100044, China.; University of Chinese Academy of Sciences, Beijing 100049, China. Department of Pediatric Orthopedic, Wuhan Puai Hospital, Tongji Medical College, Huazhong Science and Technology University, Wuhan, China Department of Laboratory Medicine, State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center, Chengdu 610041, China Department of Liver Surgery, West China Hospital, Sichuan University, Chengdu; Department of General Surgery, Mianzhu Hospital of West China hospital, Sichuan University, Mianzhu, Sichuan Province, China. Department of Biochemistry and Molecular Genetics Northwestern University Chicago Illinois USA; Robert H. Lurie Comprehensive Cancer Center Feinberg School of Medicine Northwestern University Chicago Illinois USA Department of Orthopaedics, The Affiliated Huaian Hospital of Xuzhou Medical University, Huaian, Jiangsu 223002, P.R. China Magnetic Resonance Imaging and Spectroscopy Center, University of Kentucky College of Medicine, Lexington, KY Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, NY 14260, United States; New York State Center of Excellence in Bioinformatics and Life Sciences, 701 Ellicott Street, Buffalo, NY 14203, United States Department of Psychology, Suzhou University of Science and Technology, China; Cognitive Neuroscience Laboratory, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Japan; Department of Psychology, Soochow University, China State Key Laboratory for Mesoscopic Physics and Center for Nano-optoelectronics, School of Physics, Peking University, Beijing 100871, China School of Biomedical Engineering Shanghai Jiao Tong University Shanghai China Tufts Medical Center, Tufts University, Boston, MA, USA Department of Gastroenterology, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing Department of Cardiothoracic Surgery The Fifth Hospital of Xiamen Xiamen China Shanxi Key Laboratory of Coal-based Value-added Chemicals Green Catalysis Synthesis, School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, China Department of Anesthesiology, SUNY Downstate Health Sciences University, Brooklyn, New York; Department of Cell Biology, SUNY Downstate Health Sciences University, Brooklyn, New York Department of Biostatistics and Epidemiology, School of Public Health, Shenzhen University, Shenzhen; Study Team of Shenzhen's Sanming Project, The Affiliated Luohu Hospital of Shenzhen University Health Science Center, Shenzhen, Guangdong Department of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou Huiai Hospital; and Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices Soochow University Suzhou Jiangsu 215123 P. R. China Joint International Research Laboratory of Agriculture and Agri‐Product Safety of Ministry of Education of China, Key Laboratory of Animal Breeding Reproduction and Molecular Design for Jiangsu Province, College of Animal Science and Technology Yangzhou University Yangzhou China School of Optoelectronic Science and Engineering, University of Electronic Science and Technology of China (UESTC), Chengdu, 610054, P. R. China; Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, 215123, P. R. China Department of Anesthesiology, State University of New York-Downstate Medical Center, New York, NY 11203; and Authors' Affiliations: 1Department of Surgery, Mount Sinai Hospital, University of Illinois College of Medicine, 2Robert H. Lurie Comprehensive Cancer Center, Northwestern University, Feinberg School of Medicine, Departments of 3Gastroenterology and 4Hematology-Oncology, Northwestern Memorial Hospital and Feinberg School of Medicine, 5Department of Molecular Pharmacology and Biological Chemistry, Northwestern University, and 6Jesse Brown Veterans Affairs Medical Center, Chicago, Illinois Department of Epidemiology and Health Statistics, Shenzhen University Health Science Center, Shenzhen, GD, China From the Department of Cellular Biology and Anatomy, Medical College of Georgia, Augusta, Georgia; and Department of Preventive Medicine, Shenzhen University School of Medicine Soochow University, China; Okayama University, Japan Department of Materials Science and Engineering, University of Washington, Seattle, Washington, 98195, the United States. Jiangsu Province Key Laboratory of Anesthesiology, Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology, NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs, Xuzhou Medical University, Xuzhou, China School of Physics and Astronomy and Collaborative Innovation Center of IFSA (CICIFSA) Shanghai Jiao Tong University Shanghai 200240 P. R. China Department of Cardiology, Beijing AnZhen Hospital, Capital University of Medical Science, Beijing, People's Republic of China. Department of Medical Oncology, The Fourth Affiliated Hospital, Hebei Medical University, Shijiazhuang, Hebei 050011, P. R. China. Department of Neurosurgery, The Second Affiliated Hospital, School of Medicine Xi'an Jiaotong University Xi'an Shaanxi China Department of Urology, Renji Hospital, Shanghai Jiaotong University, School of Medicine, Shanghai, China Department of Critical Care Medicine, Affiliated Hangzhou Cancer Hospital, Zhejiang University School of Medicine, Hangzhou 310022, China. From the Department of Preventive Medicine, Shenzhen University Health Sciences Center, Guangdong, China (X.L., D.Z., C.H., B.W., Y.R., J.Z., Y.Z., D.H., M.Z.); The Affiliated Luohu Hospital of Shenzhen University Health Sciences Center, Guangdong, China (Y.L., X.S., C.H., B.W., Y.R., J.Z., Y.Z., D.H.); and Department of Epidemiology and Health Statistics, College of Public Health, Zhengzhou University, Henan, China (C.H., B.W., Y.R., Y.Z., Y.S.). Guangdong Provincial Key Laboratory of Plant Resources Biorefinery, Guangzhou Key Laboratory of Clean Transportation Energy Chemistry, School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China Department of Urology The Second Hospital of Hebei Medical University Shijiazhuang China Biotechnology Core Facility Branch, Division of Scientific Resources, National Center for Preparedness, Detection, and Control of Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.; Poxvirus and Rabies Branch, Division of Viral and Rickettsial Diseases, National Center for Zoonotic, Vector-Borne, and Enteric Diseases, Coordinating Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30329, USA.; Imperial College London, St. Mary's Campus, London, W2 1PG, UK.; Bundeswehr Institute of Microbiology, Munich, Germany 80937. Department of Pharmacology, College of Basic Medical Sciences, Jilin University, 126 Xin Min Street, Changchun, Jilin 130021, China Department of Health Behavior and Social Medicine, West China School of Public Health and West China Fourth Hospital, Research Center for Palliative Care, West China‐PUMC C.C. Chen Institute of Health Sichuan University Chengdu People's Republic of China Department of Cell BiologyCleveland Clinic FoundationClevelandOhioUSA Department of Orthopaedic Surgery West China Hospital, Sichuan University Chengdu China Department of Epidemiology and Biostatistics, University of Georgia Department of Dermatology Beijing Youan Hospital Capital Medical University Beijing 100069 China Department of Sport Science, School of Physical Education, Central China Normal University, Wuhan, Hubei 430070, P.R. China Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong 510006, China Department of Plant Pathology, Sichuan Agricultural University, Chengdu 611130, P.R. China Surgical Intensive Care Unit, Children’s Hospital of Nanjing Medical University, China Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha Institute of Neurosciences, the Fourth Military Medical University, Xi’an 710032, China Department of Gastroenterology, Affiliated Kunshan Hospital of Jiangsu University Department of Anatomy, Otago School of Biomedical Sciences, Dunedin, New Zealand Department of Pharmacology, Norman Bethune College of Medicine, Jilin University, Changchun, Jilin 130021, China.; Department of General Surgery, China-Japan Union Hospital, Jilin University, Changchun, Jilin 130033, China. *CBR Institute for Biomedical Research and Department of Pathology, Harvard University, Boston, MA 02115; Medical Imaging, The First Affiliated Hospital of Xi'an Jiaotong University, Xi’an, Shaanxi, P.R. China Wuhan Institute of Marine Electric Propulsion Wuhan 430064 China; Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 China Department of Health Management Center, Yellow River Central Hospital of Yellow River Conservancy Commission, Zhengzhou, China Key Laboratory of Magnetic Resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics National Center for Magnetic Resonance in Wuhan Wuhan Institute of Physics and Mathematics Innovation Academy for Precision Measurement Science and Technology Chinese Academy of Sciences‐Wuhan National Laboratory for Optoelectronics Wuhan China; University of Chinese Academy of Sciences Beijing China Department of Biostatistics and Epidemiology School of Public Health Shenzhen University Health Science Center Shenzhen Guangdong China Department of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, Hubei 430030, China. Department of Epidemiology and Biostatistics, Key Laboratory for Environment and Health, School of Public Health Tongji Medical College, Huazhong University of Sciences and Technology Wuhan China Department of Medical Imaging, First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China Department of Cardiothoracic Surgery, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213000, P.R. China 6Ludwig Center for Cancer Genetics and Therapeutics, Howard Hughes Medical Institute, and the Sidney Kimmel Comprehensive Cancer Center, Johns Hopkins University, Baltimore, Maryland. School of Materials and Energy, University of Electronic Science and Technology of China, Chengdu 611731, Sichuan, China Department of Ophthalmology The First Affiliated Hospital of Xi'an Jiao Tong University Xi'an China State Key Laboratory of Agricultural Microbiology, College of Resources and Environment, Huazhong Agricultural University, Wuhan, China Ludwig Center for Cancer Genetics and Howard Hughes Medical Institutions, Johns Hopkins Kimmel Cancer Center, Johns Hopkins Medical Institutions, Baltimore, MD 21231; The Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Buffalo, New York 14214, United States; New York State Center of Excellence in Bioinformatics and Life Science, Buffalo, New York 14203, United States Department of Pharmacy, The Affiliated Brain Hospital of Guangzhou Medical University, Guangzhou 510370, China Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, China. Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, GA 30341, USA Department of Cardiology Beijing Anzhen HospitalCapital Medical University Beijing China Department of Preventive Medicine, Shenzhen University Health Science Center, Shenzhen, Guangdong, People's Republic of China Key Laboratory of Preclinical Study for New Drugs of Gansu Province; School of Basic Medical Sciences; Lanzhou University; Lanzhou; P. R. China Division of Rheumatology, Tufts Medical Center, Boston, Massachusetts School of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006, P. R. China Department of Gastroenterology, Drum Tower Hospital Affiliated to Medical School of Nanjing University 321#, Zhongshan Road Nanjing Jiangsu 210008 China Tsinghua University State Key Laboratory of Triology, Department of Precision Instruments and Mechanology, , Beijing 100084, China Key Laboratory of Functional Dairy, College of Food Science and Nutritional Engineering China Agricultural University Beijing China; Beijing Higher Institution Engineering Research Center of Animal Product China Gansu Chengxian Center for Disease Control and Prevention, Longnan 742500, China. Department of Otolaryngology, Eye Ear Nose & Throat Hospital, Fudan University, Shanghai, PR China; Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, PR China Department of Chemistry, University of California, Davis, California 95616, United States Jiangsu Key Laboratory of Green Synthetic Chemistry for Functional Materials School of Chemistry & Materials Science Jiangsu Normal University Xuzhou Jiangsu 221116 P. R. China From the Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, New York. Chinese Academy of Sciences , Institute of Semiconductors , Beijing , China The Institute of Cell Therapy, China Three Gorges University, Yichang, China; Medical School, Department of Pathology, Biology and Immunology, China Three Gorges University, Yichang, China Key Laboratory for Micro/Nano Optoelectronic Devices of Ministry of Education Hunan Provincial Key Laboratory of Low‐Dimensional Structural Physics and Devices School of Physics and Electronics Hunan University Changsha 410082 China Institute for Energy Research; Jiangsu University; Zhenjiang 212013; P. R. China Department of Critical Care Medicine, Beijing Ditan Hospital, Capital Medical University, Beijing 100015, China Center for Tuberculosis Research, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA School of Architecture and Civil Engineering, Anhui Polytechnic University, Wuhu 241000, China School of Educational Science, Anhui Normal University, Wuhu, Anhui, China (mainland) Institute of Anesthesia, Department of Anatomy, Baotou Medical College, Inner Mongolia, China Department of Cardiology, Beijing Anzhen Hospital, Capital Medical University, Beijing, China. Department of Liver Surgery and Liver Transplantation Center, Ren Ji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China Department of Environmental Engineering, College of Biology and the Environment, Nanjing Forestry University, Nanjing, Jiangsu 210037, P. R. China Department of Medical Imaging, The First Affiliated Hospital of Xi’an Jiaotong University , Xi’an, China Department of Otorhinolaryngology, Eye & ENT Hospital Fudan University Shanghai China Jiangsu Province Key Laboratory of Anesthesiology Xuzhou Medical University Xuzhou China; Jiangsu Province Key Laboratory of Anesthesia and Analgesia Application Technology Xuzhou Medical University Xuzhou China; NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs Xuzhou China Key Laboratory of Advanced Textile Materials and Manufacturing Technology of the Ministry of Education, College of Materials and Textiles, Zhejiang Sci-Tech University, Hangzhou 310018, P. R. China Qinghai Key Laboratory of Tibetan Medicine Pharmacology and Safety Evaluation; Northwest Institute of Plateau Biology; Chinese Academy of Sciences; Xining; China Department of Psychology, Research Center for Psychology and Behavioral Sciences, Soochow University, Suzhou, China; Cognitive Neuroscience Laboratory, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Japan Department of Psychology, Research Center for Psychology and Behavioral Sciences, Soochow University, Suzhou, China; Laboratory, Graduate School of Interdisciplinary Science and Engineering In Health Systems, Okayama University, Okayama, Japan Department of Medical Imaging, First Affiliated Hospital of Xi'An Jiaotong University College of Medicine, Xi'an, Shaan'Xi, China. State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences China Agricultural University Beijing China; Center for Crop Functional Genomics and Molecular Breeding China Agricultural University Beijing China Department of Urology Transplantation Center, Ren Ji Hospital Shanghai Jiao Tong University School of Medicine Pudong District Shanghai China Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovative Academy of Precision Measurement Science and Technology, Chinese Academy of Sciences–Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology Wuhan People’s Republic of China The Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Amherst, NY 14260, United States; New York State Center of Excellence in Bioinformatics and Life Sciences, Buffalo, NY 14203, United States Department of Civil Engineering, P.O. Box 400742, Thornton Hall, University of Virginia, Charlottesville, Virginia 22904-4742 Interdisciplinary Division of Biomedical Engineering Faculty of Engineering The Hong Kong Polytechnic University Kowloon Hong Kong China Department of Psychology, College of Education Northeast Normal University Changchun 130024 China; Key Laboratory for Applied Statistics of MOE Northeast Normal University Changchun 130024 China; Academy of Psychology and Behavior TianJin Normal University TianJin 300074 China Department of Neurosurgery The Second Affiliated Hospital of Xi'an Jiaotong University Shannxi China Department of Anatomy, University of Otago, Dunedin, New Zealand. Hainan University-HSF/LWL Collaborative Innovation Laboratory, School of Food Science and Engineering, Hainan University , 58 People Road, Haikou 570228 , PR China Department of Automation, Faculty of Information Technology, Beijing University of Technology, Beijing, China; The Beijing International Collaboration Base on Brain Informatics and Wisdom Services, Beijing, China Department of Endocrinology, Second Hospital, Lanzhou University, Lanzhou, Gansu, 730030, P. R. China. State Key Laboratory of Chemical Resource Engineering Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Beijing 100029 China Department of Pathology Haidian Maternal & Children Health Hospital Beijing China Key Laboratory for Green Chemical Process of Ministry of Education; Wuhan Institute of Technology; Wuhan 430073; P. R. China School of Cultural Heritage, Northwest University, Xi’an 710069, China. National and Local Joint Engineering Research Center for the Exploitation of Homology Resources of Medicine and Food, Guizhou University, Guiyang 550025, P. R. China Department of Surgery, The Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, 600 Yishan Road, Shanghai 200233, People’s Republic of China School of Engineering, Changchun Normal University, Changchun, China; School of Transportation Science and Engineering, Harbin Institute of Technology, Harbin, China Department of Environmental Toxicology Institute of Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention No. 7 Panjiayuan nanli, Chaoyang district Beijing 100021 China School of Optoelectronic Information, University of Electronic Science and Technology of China (UESTC), Chengdu 610054, P.R. China *Department of Inflammation and Key Laboratory for Poultry Genetics and Breeding of Jiangsu Province, Chinese Academy of Agricultural Science, Institute of Poultry Science, Yangzhou, China Key Laboratory for Micro-Nano Optoelectronic Devices of Ministry of Education, School of Physics and Microelectronics, State Key Laboratory for Chemo/Biosensing and Chemometrics, Hunan University, Changsha 410082, China College of Life Sciences, Zhejiang University, Hangzhou, People's Republic of China. The Institute of Genetics, College of Life Sciences, Zhejiang University, Hangzhou 310058, China Department Liver Surgery and Liver Transplantation Shanghai Jiao‐tong University School of Medicine Renji Hospital Shanghai China Department of Vascular Surgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China.; *They contributed equally to this work. 3Department of Epidemiology and Biostatistics, School of Public Health, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, Hubei, China. Department of Biomedical Engineering The Hong Kong Polytechnic University Hong Kong China Department of Medical Imaging, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China Dementia Care & Research Center, Beijing Dementia Key Lab, Peking University Institute of Mental Health (Sixth Hospital), Beijing, China; National Clinical Research Center for Mental Disorders, NHC Key Laboratory of Mental Health, Beijing, China; Department of Psychiatry, the Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China Key Laboratory of Magnetic Resonance in Biological Systems, State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, National Center for Magnetic Resonance in Wuhan, Wuhan Institute of Physics and Mathematics, Innovation Academy for Precision Measurement Science and Technology, Chinese Academy of Sciences‐Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan China; University of Chinese Academy of Sciences Beijing China Department of Radiology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China. Department of Vascular Surgery, Drum Tower Hospital, Nanjing University School of Medicine, Nanjing, Jiangsu, China Division of Liver Surgery, Department of General Surgery West China Hospital, Sichuan University Chengdu China Department of Obstetrics and Gynecology Tianjin First Center Hospital Tianjin China School of Materials and Energy University of Electronic Science and Technology of China Chengdu Sichuan 611731 China Department of Burns and Plastic Surgery The Fourth Medical Center of Chinese PLA General Hospital Beijing China Department of Neurology, Second Affiliated Hospital of Nanchang University, Nanchang, China; College of Materials and Textiles Key Laboratory of Advanced Textile Materials and Manufacturing Technology of the Ministry of Education Zhejiang Sci‐Tech University Hangzhou 310018 P. R. China Institute of Cardiovascular Sciences, St Boniface General Hospital Research Centre, and Departments of Physiology and Internal Medicine, Faculty of Medicine, University of Manitoba, Winnipeg, Manitoba. Department of Oncology Johns Hopkins University School of Medicine Baltimore MD USA Department of Medical Imaging; First Affiliated Hospital of Xi'an Jiaotong University; Xi'an People's Republic of China Department of Biomedical Engineering, The Hong Kong Polytechnic University, Hong Kong, China Department of Liver Surgery West China Hospital Sichuan University Chengdu China Departments of Anesthesiology, SUNY Downstate Health Science University, 450 Clarkson Avenue, Brooklyn, NY 11203, USA; Departments of Cell Biology, SUNY Downstate Health Science University, 450 Clarkson Avenue, Brooklyn, NY 11203, USA Department of Otolaryngology-Head and Neck Surgery, Fudan University affiliated Eye, Ear, Nose and Throat Hospital, Shanghai, China; Senior Lecturer in Anatomy. Department of Epidemiology and Biostatistics Institute of Bioinformatics, University of Georgia Athens Georgia Department of Experimental Pharmacology and Toxicology, School of Pharmacy Jilin University Changchun Jilin Province China Heilongjiang Key Laboratory for Laboratory Animals and Comparative Medicine, College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, China 5School of Food and Chemical Engineering, Beijing Technology and Business University, Beijing, China Department of Radiology, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an 710061, China University of Alberta, Faculty of Rehabilitation Medicine, Edmonton, AB, Canada; Alberta Health Services, Glenrose Rehabilitation Hospital, Edmonton, AB, Canada Department of Medical Ultrasonics, Haihe Hospital, Tianjin University, Tianjin 300350, China Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, China. Institute of Cell Biology and Genetics, College of Life Sciences, Zhejiang University, Hangzhou, China. Department of Oncology, Sichuan Provincial People's Hospital, Sichuan, P.R. China; Department of Radiation Oncology, Hebei General Hospital, Shijiazhuang, China. Department of Anatomy University of Otago Dunedin New Zealand From the Department of Laboratory Medicine and Pathobiology (D.D., P.J.B.S., T.C.V.R., J.T.K.L., M.Z., B.L.L.), University of Toronto, Toronto, Ontario, Canada; Toronto General Research Institute (D.D., P.J.B.S., T.C.V.R., J.T.K.L., M.Z., B.L.L.), University Health Network, Toronto, Ontario, Canada; and the Department of Surgery (A.K.), University of Toronto and St Michael’s Hospital Research Institute, Toronto, Ontario, Canada. From the Tanz Centre for Research in Neurodegenerative Diseases (P.M., M.Z., C.S., D.M., S.X., A.B.Z., P.M.M., A.W., R.S., J.R., E.R.), Department of Medicine (L.Z., E.R.), Division of Neurology, and Department of Laboratory Medicine and Pathobiology (J.R.), University of Toronto, Ontario, Canada; Department of Neuroscience (M.v.B., L.P., R.R.), Mayo Clinic, Jacksonville, FL; and Sunnybrook Health Sciences Centre (J.K., L.Z.), Toronto, Ontario, Canada. Suzhou University of Science and Technology, Jiangsu, China; Soochow University, Jiangsu, China; Okayama University, Okayama, Japan Department of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine, Fourth Military Medical University, Xi’an 710032, China 2Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan; and College of Chemistry and Materials Engineering, Wenzhou University, Wenzhou 325027, China Department of Psychology, Soochow University, Suzhou, China; Research Center for Psychology and Behavioral Sciences, Soochow University, Suzhou, China; Cognitive Neuroscience Laboratory, Graduate School of Interdisciplinary Science and Engineering in Health Systems, Okayama University, Okayama, Japan; Department of Psychology, Suzhou University of Science and Technology, Suzhou, China; [email protected] Department of Radiology, The Affiliated Changzhou No. 2 People’s Hospital, Nanjing Medical University, Changzhou, Jiangsu Province, P.R. China Department of Animal Sciences , Washington State University, Pullman, Washington 99164-6351 Key Laboratory of Green Chemistry, Jiangxi Province and College of Chemistry, Jiangxi Normal University Department of Gastroenterology, Drum Tower Hospital of Nanjing School of Life Sciences, Central South University ‡Tianjin Translational Genomics Center, BGI–Tianjin, Tianjin 300308, China;; §BGI–Shenzhen, Shenzhen 518083, China; Dana–Farber Cancer Institute and Harvard Medical School, 44 Binney Street, Boston, MA 02115 Hubei No. 3 People’s Hospital of Jianghan University, Wuhan, Hubei, China (mainland) Global Health Institute, Ecole Polytechnique Fédérale de Lausanne, Lausanne, Switzerland Department of Laboratory Medicine, State Key Laboratory of Biotherapy and Clinical Laboratory Medicine Research Center, West China Hospital, Sichuan University, Chengdu, 610041, China State Key Laboratory of Agricultural Microbiology, College of Resources and Environment, Huazhong Agricultural University , China Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106 Department of General Practice, Honghui Hospital, Xi’an Jiao Tong University, Shaanxi 710054, P.R. China Department of Radiotherapy, Gansu Provincial Cancer Hospital, Lanzhou, Gansu, China Department of Pharmaceutical Sciences, University at Buffalo, State University of New York, Kapoor 318, North Campus, Buffalo, New York 14260, United States; New York State Center of Excellence in Bioinformatics and Life Sciences, 701 Ellicott Street, Buffalo, New York 14203, United States Binhai Genomics Institute, BGI-Tianjin, Tianjin, China Department of Anesthesiology and Perioperative Medicine, Xijing Hospital, the Fourth Military Medical University. 127th West Changle Road, Xi’an, 710032, Shaanxi, P.R. China; General Hospital of Chengdu Military Region of Chinese PLA, the 270th Tianhui Road, Chengdu, 610083, Sichuan, P.R. China Center for Pulmonary and Infectious Disease Control,1 Department of Cellular Biology and Anatomy, Medical College of Georgia at Augusta University and Charlie Norwood VA Medical Center, Augusta, Georgia, United States Theoretical Biology and Biophysics Group, Theoretical Division, Los Alamos National Laboratory, Los Alamos, NM, 87545.; Department of Bioinformatics, Institute of Microbiology and Genetics, University of Göttingen, 37077 Göttingen, Germany. State Key Laboratory of Automotive Simulation and Control Jilin University Changchun 130022 People's Republic of China Department of Agricultural and Biological Engineering, University of Florida, Gainesville, Florida 32611, United States Department of Endodontics, The Affiliated Stomatological Hospital, Fujian Medical University, Fuzhou 350002, China. State Key Laboratory of Materials-Oriented Chemical Engineering, College of Chemical Engineering, Nanjing Tech University, Nanjing 210009, China Medical College of Nankai University, Tianjin 300071, PR China Department of Neurosurgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi, China; Department of Epidemiology and Biostatistics, University of Georgia, Athens, GA, U.S.A Department of Health Technology and Informatics, The Hong Kong Polytechnic University, Kowloon, Hong Kong Material Science and Engineering College, Key Laboratory of Bio-based Material Science and Technology, Ministry of Education, Northeast Forestry University, Harbin 150040, China Department of Gastroenterologic Surgery Affiliated Tumor Hospital of Harbin Medical University 6 Baojian Road 150040 Harbin China State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics National Center for Magnetic Resonance in Wuhan Wuhan Institute of Physics and Mathematics Chinese Academy of Sciences Wuhan 430071 China Department of Gastroenterology Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing Jiangsu Province China State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics Chinese Academy of Sciences, Lanzhou 730000, China Department of Cardiology, Beijing An Zhen Hospital, Capital Medical University, and Beijing Institute of Heart, Lung and Blood Vessel Disease, Beijing 100029, China Department of Anatomy and; Department of Anatomy, Anhui Medical University, Hefei, China Department of Pharmacology, Nanomedicine Engineering Laboratory of Jilin Province, College of Basic Medical Sciences and School of Nursing, Jilin University, Changchun 130021, China. School of Earth Sciences, China University of Geosciences, Wuhan 430074, China. Nanjing Center, China Geological Survey, Nanjing 210016, China. Department of Urology and Andrology , Renji Hospital, , 200001 , China; Shanghai Jiao Tong University School of Medicine, Shanghai Institute of Andrology, Shanghai , Renji Hospital, , 200001 , China Jiangsu Province Engineering Research Center of Stomatological Translational Medicine Nanjing Medical University Nanjing 210029 China Department of Otolaryngology Shanghai Key Clinical Disciplines of otorhinolaryngology Eye Ear Nose and Throat Hospital Fudan University Shanghai China State Key Laboratory and Institute of Elemento-Organic Chemistry College of Chemistry Nankai University 94 Weijin Road Tianjin 300071 China Dept. of Orthodontics, West China College of Stomatology, Sichuan University, Chengdu 610041, China. Department of Clinical Laboratory, Changzhou Woman and Children Health-Care Hospital Affiliated to Nanjing Medical University, Jiangsu, China. Guangzhou Beile Food Co., Ltd. Guangzhou P. R. China Department of Pharmacology, College of Basic Medical Sciences, School of Nursing, Jilin University, Changchun 130021, China. Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390-9038; |
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