http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_819abf18a8953909d21a206bd93ab0cb
Outgoing Links
| Predicate | Object |
|---|---|
| family-name | Zhou Yan Zhou |
| name | Yan Zhou |
| given-name | Yan |
| organization-name | Information Management Section, Bethune International Peace Hospital, Shijiazhuang, Hebei Province, China American Board of Anesthesiology, Raleigh, North Carolina Oncology Department of Shanghai Jiao Tong University Affiliated Sixth People's Hospital of Shanghai, Shanghai, China, 200233 Department of Obstetrics, Wuhan Children's Hospital (Wuhan Maternal and Child Health Care Hospital), Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Clinical Laboratory Medicine, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, P. R. China; Shanghai Institute of Thoracic Oncology, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, 200030, P. R. China Hangzhou Genomics Institute, Hangzhou, PR China; James D. Watson Institute of Genome Sciences, Zhejiang University, Hangzhou, PR China; Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou, PR China Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China Department of Radiology, Ren Ji Hospital, Shanghai Jiao Tong University School of Medicine, China (B.S., X.G., X.L., J.Z., Z.Z., X.L., Y.Z., J.X., H.Z.). State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, China Chinese Academy of Sciences; University of Chinese Academy of Sciences Department of Rheumatology and Immunology, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China Department of Graduate School Tianjin Medical University Tianjin China State Key Laboratory of Oncogenes & Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200032, PR China; Central Laboratory, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, 200127, PR China School of Life Sciences, Nanchang University, Nanchang, China State Key Laboratory of Bioreactor Engineering East China University of Science and Technology Shanghai China Department of Pediatric Surgery Capital Institute of Pediatrics Beijing People's Republic of China; Graduate School of Peking Union Medical College Chinese Academy of Medical Sciences Beijing People's Republic of China Department of Radiotherapy, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui, China (mainland) Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Anhui Medical University, Hefei, Anhui 230032, China National Key Laboratory of Green Pesticide, International Joint Research Center for Intelligent Biosensing Technology and Health, College of Chemistry, Central China Normal University, Wuhan 430079, P. R. China Department of Chemistry and Biochemistry; Florida State University; Tallahassee; USA Laboratory of Addictive Diseases, Rockefeller University, New York, USA Institute of Stomatological Research of Sun Yat-sen University, Guangzhou, Guangdong, China. Department of Central Lab, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210023, China Department of Biomedicine, Aarhus University, Aarhus C, Denmark. Epigenetics Unit and Department of Anesthesia, The Sixth Affiliated Hospital, Sun Yat-sen University, Guangzhou, China State Key Laboratory of Bioreactor Engineering; East China University of Science and Technology; Shanghai People's Republic of China Center for Vaccines and Immunity, Research Institute at Nationwide Children's Hospital, Columbus, OH 43205; and Key Laboratory of Structural Biology of Zhejiang Province School of Life Sciences Westlake University Hangzhou China; Center for Infectious Disease Research Westlake Laboratory of Life Sciences and Biomedicine Hangzhou China; Institute of Basic Medical Sciences Westlake Institute for Advanced Study Hangzhou China Fox Chase Cancer Center, Philadelphia, Pennsylvania, USA Department of Cardiology, Shaoxing People’s Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing, Zhejiang 312000, China Chemical Biology Research Center; School of Pharmaceutical Sciences; Wenzhou Medical University; Wenzhou; China West China Hospital, Sichuan University; Center of Geriatrics and Gerontology; No. 37, Guo Xue Xiang Chengdu Sichuan China 610041 CAS Key Laboratory of Engineering Plastics, Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, The Chinese Academy of Sciences, Beijing 100190, China; University of Chinese Academy of Sciences, Beijing, 100049, China Department of Biochemistry and Molecular Biology Medical College Nantong University Nantong China Vaccine and Infectious Disease Organization-International Vaccine Centre (VIDO-InterVac), University of Saskatchewan, Saskatoon, SK, Canada; Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, SK, Canada; Vaccinology and Immunotherapeutics Program, School of Public Health, University of Saskatchewan, Saskatoon, SK, Canada School of Laboratory Medicine, Wenzhou Medical University, Zhejiang, China Department of Medicine, Johns Hopkins University School of Medicine Respiratory Department, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121001, P.R. China Programs in Biostatistics, Fox Chase Cancer Center, Philadelphia, PA, USA Clinical Nutrition Department, The Second People’s Hospital of Yunnan Province, Kunming Yunnan 650021, China Laboratory of the Biology of Addictive Diseases The Rockefeller University New York New York Department of Pharmaceutics and Pharmaceutical Chemistry, Center for Controlled Chemical Delivery, and State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Fujian Agriculture and Forestry University, Fuzhou 350002, China; Fujian Provincial Key Laboratory of Insect Ecology, Department of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou 350002, China Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, People’s Republic of China State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macao SAR, China Department of Ultrasound, The Third Central Hospital of Tianjin, Tianjin, China; Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Tianjin Institute of Hepatobiliary Disease, Tianjin Third Central Hospital, Tianjin, China MRC Weatherall Institute of Molecular Medicine, University of Oxford, Oxford, United Kingdom Department of Radiation Biology, Faculty of Preventive Medicine Fourth Military Medical University Xi'an China Key Laboratory of Flexible Electronics (KLOFE) & Institution of Advanced Materials (IAM), School of Flexible Electronics (Future Technologies), Nanjing Tech University (NanjingTech), Nanjing, Jiangsu 211816, P.R. China National Engineering Laboratory for AIDS Vaccine School of Life Sciences, Jilin University Changchun 130012 China; Key Laboratory for Molecular Enzymology and Engineering the Ministry of Education, School of Life Sciences, Jilin University Changchun 130012 China School of pharmaceutical Sciences; Jilin University; Changchun; China Department of Pulmonary and Critical Care Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110004, China Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China; Frontiers Science Center for Synthetic Biology (Ministry of Education), Tianjin University, Tianjin 300072, China Hangzhou Women’s Hospital (Hangzhou Maternity and Child Health Care Hospital), Hangzhou, China Department of Laboratory Medicine, West China Second University Hospital, Sichuan University Chengdu 610041, Sichuan Province, China. Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education Chengdu 610041, Sichuan Province, China. NHC Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, School of Medicine University of Electronic Science and Technology of China Mianyang Sichuan PR China Wenzhou Key Laboratory of Sanitary Microbiology, Key Laboratory of Laboratory Medicine, Ministry of Education, China, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang 325000, P.R. China Department of Endocrinology Dongyang People's Hospital Dongyang China Department of Gastrointestinal Surgery, The Second Hospital of Shandong University, Shandong 250000, P.R. China Hospital of Stomatology, Sun Yat-sen University, Guangzhou 510055, China; Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou 510055, China Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology Chinese Academy of Sciences Chengdu 610041 P.R. China Department of Pediatrics, Beijing Tongren Hospital Capital Medical University Beijing China Department of Physical Sciences (Chemistry), University of Hull, Cottingham Road, Kingston-upon-Hull HU6 7RX, Humberside, United Kingdom National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai 200025, China. Institute of Translational Medicine, Nanchang University, Nanchang, Jiangxi 330088, China Department of Hematology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China Center of Gastrointestinal Disease, The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, China Key Laboratories of Bioorganic Chemistry and Molecular Engineering and of Polymer Chemistry and Physics of the Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China; Institute of Polymer Optoelectronic Materials and Devices, South China University of Technology, the Key Laboratories of Specially Functional Materials of Ministry of Education, Guangzhou 510640, China Institute of Chinese Medicine, Department of Biochemistry and Department of Biology, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, People's Republic of China, Beth Israel Deaconess Medical Center, Harvard Medical School, 330 Brookline Avenue, Boston, Massachusetts 02215, Institute of Chinese Medicine and Natural Products, Jinan University, Guangzhou, People's Republic of China, and Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong Science Park, Shatin, New... Department of Spine Center, Zhongda Hospital, Medical School, Southeast University, Nanjing, People’s Republic of China People's Hospital of Ningxia Hui Autonomous Region (Ningxia Medical University Affiliated People's Hospital of Autonomous Region) Yinchuan China State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, P.R. China School of Mathematics and Statistics, Shenzhen University, Shenzhen, China The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Lab of Ophthalmology, Chongqing Eye Institute, Youyi Road 1, Chongqing 400016, China The First Medical College of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310053, PR China National Research Institute of Brewing, 3-7-1 Kagamiyama, Higashi-Hiroshima, Hiroshima 739-0046, Japan 4Department of Oncology, Yixing People's Hospital, Yixing, China. University of California San Francisco 1 Departments of Stomatology , , San Francisco, CA 94143-0512, USA Co-Innovation Center for Sustainable Forestry in Southern China/College of Biology and the Environment, Nanjing Forestry University, Nanjing, China Department of Medical Microbiology, School of Medicine, Wuhan University, Wuhan 430071, P.R. China The National Center for Drug Screening, the Chinese Academy of Sciences Key Laboratory of Receptor Research and the State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences (CAS), Shanghai 201203, China †Research Institute of Fox Chase Cancer Center, Philadelphia, PA 19111; and Vaccine and Infectious Disease Organization-International Vaccine Center, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Vaccinology & Immunotherapeutics Program, School of Public Health, University of Saskatchewan, Saskatoon, Saskatchewan, Canada 2Department of Biostatistics and Bioinformatics, Fox Chase Cancer Center, Philadelphia, Pennsylvania. Department of Critical Care Medicine, West China Hospital, West China Medical School, Sichuan University, Chengdu, China Respiratory Department The First Xiangya Hospital of Central South University Changsha China; Respiratory Department The Third Xiangya Hospital of Central South University Changsha China Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China Medical Department, Affiliated Hospital of Chinese PLA General Hospital, Beijing 100048, China CAS Key Laboratory of Engineering Plastics and CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China; College of Chemistry, University of Chinese Academy of Sciences, Beijing 100049, P. R. China Department of Critical Care Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China The State Key Laboratory of Bioreactor Engineering, School of Bioengineering, East China University of Science and Technology, Shanghai, 200237, China Department of Thyroid Surgery, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550004, P.R. China Department of Gastrointestinal Surgery Affiliated Changzhou No.2 People's Hospital of Nanjing Medical University, Changzhou Medical Center, Nanjing Medical University Changzhou P. R. China Department of Otorhinolaryngology Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Chengdu Institute of Biology,Chinese Academy of Sciences Chengdu 610041,China. Center for Vaccines and Immunity, the Research Institute at Nationwide Children’s Hospital, Columbus, OH 43205 1 *Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University, Chikusa-ku, Nagoya 464-8601, Japan; and Sir Run Run Shaw Hospital School of Medicine Zhejiang University Hangzhou China Shaoxing People’s Hospital (Shaoxing Hospital, Zhejiang University School of medicine), Shaoxing, Zhejiang Province, P.R. China Department of Chemistry State Key Laboratory of Elemento-Organic Chemistry Nankai University Tianjin 300071 P. R. China Department of Bioinformatics, Genentech, Inc., South San Francisco, California 94080, USA. Department of NeurosciencesMedical University of South CarolinaCharlestonSouth CarolinaUSA Key Laboratory of Functional, Ministry of Education, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, China Department of Hospital Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX Department of Pharmacy, The First Hospital of Lanzhou University, Lanzhou, China; Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, No. 9 Section 4, Renmin South Road, Chengdu 610041, P.R. China 2Stomatology, Brain Tumor Research Center of the Departments of Neurological Surgery and Pediatrics, University of California San Francisco, San Francisco, California 94143, USA Department of Laboratory Medicine Zhongshan Hospital, Fudan University Shanghai China Institute of Semiconductors; University of Chinese Academy of Sciences Department of Neurosurgery, Air Force Medical Center, Beijing 100142, China National Center for Gene Research, National Center for Plant Gene Research (Shanghai) and Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200233, China Chengdu Institute of Biology, Chinese Academy of Sciences, 610041, Chengdu, People’s Republic of China 2Department of Pathology, School of Basic Medical Sciences, Peking University, Beijing, People's Republic of China; and Chongqing Academy of Animal Sciences, Chongqing 402460, China Department of Cell and Tissue Biology, University of California San Francisco,San Francisco, CA 94143, USA Gastroenterology Tumor and Microenvironment Laboratory, Department of Gastroenterology, The First Affiliated Hospital of Chengdu Medical College, Chengdu Medical College, Chengdu, Sichuan 610041, P.R. China State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, China; Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, China Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Department of Information Management Section, Bethune International Peace Hospital, Shijiazhuang, Hebei 050000, P.R. China CAS Key Laboratory of High‐Performance Synthetic Rubber and its Composite Materials Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China Department of Biomedical Sciences, Creighton University, Omaha, Nebraska, U.S.A.; Osteoporosis Research Center, Creighton University, Omaha, Nebraska, U.S.A. Affiliated Cancer Hospital & Institute of Guangzhou Medical University Authors' Affiliations: 1Program in Developmental Therapeutics and 2Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, Philadelphia, Pennsylvania; 3The Research Institute at Nationwide Children's Hospital and the Department of Pediatrics, The Ohio State University, Columbus, Ohio; 4Kennedy Krieger Institute, Johns Hopkins University, Baltimore, Maryland; and 5Lombardi Comprehensive Cancer Center, Georgetown University Medical Center, Washington, District of Columbia Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Pharmacy School of Xuzhou Medical University Xuzhou City Jiangsu Province 221004 P.R. China State Key Laboratory of Coordination Chemistry, Collaborative Innovation Center of Advanced Microstructures, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China State Key Laboratory of Superlattices and Microstructures, Institute of Semiconductors Chinese Academy of Sciences Beijing 100083 P. R. China Departments of Respiratory Medicine, Affiliated Hangzhou First People's Hospital, Nanjin Medical University, Hangzhou, Zhejiang, P.R. China Department of General Surgery, Affiliated Jinling Hospital, Medical School of Nanjing University, Nanjing, China Advanced Environmental Biotechnology Center, Nanyang Environment and Water Research Institute, Nanyang Technological University, CleanTech One, Singapore 637141 School of Pharmacy North Sichuan Medical College Nanchong 637000 PR China Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China Dermatology, University of California, Davis, CA; Department of Dermatology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province, China Optoelectronic System Laboratory, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China; Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China The National Engineering Research Center for Bioengineering Drugs and the Technologies; Institute of Translational Medicine; Nanchang University; Nanchang; China Department of Agronomy, Iowa State University, Ames, IA 50011; Faculty of Engineering China University of Geosciences Wuhan Hubei 430074 China Department of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, China Zhejiang Sci-Tech University; Department of Electronics, Carleton University Colorectal Surgery Department, The Second Hospital of Jilin University, Jilin, China Department of Pharmacology, Pharmacy School, Xuzhou Medical University, Xuzhou, Jiangsu 221004, China Advanced Environmental Biotechnology Centre, Nanyang Environment and Water Research Institute, Nanyang Technological University, Singapore; School of Civil and Environmental Engineering, Nanyang Technological University, Singapore Department of Orthopaedics Renmin Hospital Wuhan University Wuhan City China Department of Anesthesiology, Beijing Jishuitan Hospital, Beijing 100035, China. Obstetrics Department of Wuhan Central Hospital, Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, China Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiaotong University , Shanghai , China Department of Anesthesiology Beijing Jishuitan Hospital Beijing China Shenzhen Institute of Artificial Intelligence and Robotics for Society (AIRS), The Chinese University of Hong Kong, Shenzhen, Guangdong 518129, China. Department of Radiology, Ren Ji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai 200127 China State Key Laboratory of Environment-Friendly Energy Materials, School of Materials and Chemistry, Southwest University of Science and Technology, Mianyang 621010, China The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, People's Republic of China Department of Chemistry; University of Cincinnati; Cincinnati, OH 45221, USA Medical College, Hebei University of Engineering, Handan 056002, Hebei, China Department of Liver Disease and Infection, 906 Hospital of PLA, Ningbo 315040, Zhejiang, China Department of Physics, University of Hong Kong, Hong Kong, P. R. China; York-Nanjing Joint Center for Spintronics and Nano Engineering (YNJC), School of Electronics Science and Engineering, Nanjing University, Nanjing 210093, China Department of Radiation Medicine, Faculty of Preventive Medicine, The Fourth Military Medical University, Xi'an, People's Republic of China. Department of Oncology, Yixing Hospital Affiliated to the Medical College of Yangzhou University, Yangzhou University, Yixing, Jiangsu 214200, P.R. China for the STOP-COVID Investigators Beijing National Laboratory for Molecular Sciences, Key Laboratory of Organic Solids, Institute of Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190, China, Key Laboratories of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China, and State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, Beijing 100029, China Department of Orthodontics, People's Hospital of Guangxi Zhuang Autonomous Region, Nanning 530021, China. [email protected] Department of Chemistry, Case Western Reserve University, Cleveland, Ohio 44106 Department of Microbiology, College of Life Science, Hunan Normal University, Changsha 410081, Hunan, China Breast Disease Center, the First Affiliated Hospital of The Third Military Medical University, Chongqing 400038, China 3Yi-xing People's Hospital, Yi-xing City, Jiangsu Province, China; and Department of Medicine Laboratory The Second People's Hospital of Lianyungang Xinpu China Department of Interventional Radiology & Vascular Surgery, The First Affiliated Hospital of Jinan University, Guangzhou, China Institute of Poultry Science, Academy of Agricultural Sciences of Shandong Province, Jinan, 250023, Shandong, China; Poultry Breeding Engineering Technology Center of Shandong Province, Jinan, 250023, Shandong, China State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection Chinese Academy of Agricultural Sciences Beijing China Department of Pharmacology and Chemical Biology, Shanghai Jiao Tong University School of Medicine, 280 South Chongqing Road, Shanghai 200025, China State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, China; College of Food Science and Technology, Nanchang University, Nanchang, China Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, P. R. China Division of HIV/AIDS and Sex‐Transmitted Virus Vaccines National Institutes for Food and Drug Control Beijing China Department of Cardiology Affiliated Hospital of Yangzhou University, Yangzhou University Yangzhou Jiangsu China Department of Surgical Urology, Wenshang County’s First People’s Hospital, Wenshang, Shandong, China (mainland) Fox Chase Cancer Center Philadelphia Pennsylvania The Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education and the Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China Infinitus (China) Company Ltd., Guangzhou 510665, China Central Laboratory, The Affiliated Hospital of Nanjing Medical University, Changzhou No. 2 People's Hospital, Changzhou, Jiangsu 213003, P.R. China Department of Neurology, Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai People's Republic of China The State Kay Laboratory of Bioreactor Engineering East China University of Science and Technology Shanghai China Department of Dermatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, P.R. China. Institute of Neurological Diseases Xuzhou Medical University Xuzhou China; Department of Neurology The Affiliated Hospital of Xuzhou Medical University Xuzhou China Cardiovascular Department, Graduate School of Beijing University of Chinese Medicine, Beijing, China Department of Pharmaceutics and Pharmaceutical Chemistry/CCCD University of Utah Salt Lake City Utah 84112 USA From the American Board of Anesthesiology, Raleigh, North Carolina (Y.Z., H.S., A.M., M.T.K., A.J.P., T.W., A.E.H., D.O.W.); Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, California (A.M.); Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota (M.T.K., D.O.W.); Department of Anesthesiology, University of Nebraska Department of Gastrointestinal Surgery, Hospital Affiliated 5 to Nantong University (Taizhou People’s Hospital) Taizhou, Jiangsu Province, China Department of Infectious Disease, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China Department of Chemistry, School of Science, and Xi’an Key Laboratory of Sustainable Energy Materials Chemistry, Xi’an Jiaotong University, Xi’an 710049, P. R. China Massachusetts Institute of Technology Department of Chemistry, , Cambridge, Massachusetts 02139, USA Radiology Shanghai Jiao Tong University School of Medicine Affiliated Renji Hospital Shanghai China School of National Defence Science & Technology; Southwest University of Science and Technology; Mianyang; P. R. China National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, Jilin Province, China; Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University, Changchun, Jilin Province, China 1Department of Experimental Research, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, P.R. China. 3Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan 430060, China; Central Laboratory, Renmin Hospital of Wuhan University, Wuhan 430060, China School of Chemistry and Chemical Engineering, Nanjing University, Nanjing, China Department of Surgery, Yixing People's Hospital, Yixing, China. The First Clinical Medical College, Zhejiang Chinese Medical University, Zhejiang, China Department of Intensive Care Unit, West China Hospital, Chengdu, Sichuan, China College of Life Sciences Wuhan University Wuhan PR China Department of Endocrinology, First Affiliated Hospital of Jinan University; College of Nursing, Jinan University, Guangzhou Department of Respiratory Medicine, Shengjing Hospital of China Medical University, Shenyang, Liaoning 110022, P.R. China Department of central laboratory, Renji Hospital, School of Medicine, Shanghai JiaoTong University, Shanghai, China Materials Science and Technology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830, United States; Materials Science and Engineering, Texas A&M University, College Station, Texas 77843, United States Department of Chemistry; Hong Kong Baptist University; Kowloon Tong; China State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200032 China; Central Laboratory Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China; Micro‐Nano Research and Diagnosis Center Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China School of Chemistry and Chemical Engineering Guangxi University for Nationalities 530006 Nanning People's Republic of China 1Molecular Pathology and Departments of Department of Oral and Maxillofacial Surgery, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, P.R. China Research Institute of Nephrology, Jinling Hospital, Nanjing University School of Medicine, Nanjing, PR China The General Hospital of the Air Force, PLA Department of Gynecology, Affiliated Hospital of Jining Medicine University Jining 272000, Shandong, The People's Republic of China. Fudan University and Chinese National Human Genome Centre, Shanghai, P.R. China. Department of Infectious Diseases, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China Key Laboratory of Sensor Networks and Environmental Sensing, Hohai University, Changzhou 213022, China Department of Laboratory Medicine and Pathology, University of Minnesota Medical School , Minneapolis, MN , USA Shenyang Haiwang Biotechnology Co. Ltd, Shenyang, China Department of Intensive Care Unit West China Hospital Sichuan University Chengdu Sichuan 610041 China Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China, Washington University, Campus Box 1134, One Brookings Drive, St. Louis, Missouri 63130, and Natural Products Drug Discovery, Herbstandard, Inc., 12305 New Avenue, Lemont, Illinois 60429 Department of Endocrinology Nanning Institute of Transfusion Medicine, Nanning, China. Poultry Institute Shandong Academy of Agricultural Sciences Ji’nan P. R. China; Poultry Breeding Engineering Technology Center of Shandong Province Ji’nan P. R. China; The Key Lab of Poultry Disease Diagnosis and Immunology of Shandong Province Ji’nan P. R. China Medical Research Center, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213003, P.R. China Department of Radiology, First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China Department of Anesthesiology, Beijing Jishuitan Hospital, Beijing, China (mainland) Institute of Pharmaceutics College of Pharmaceutical Sciences Zhejiang University Hangzhou Zhejiang 310058 P. R. China State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai, China Department of Obstetrics and Gynecology Wuhan Medical Care Center for Women and Children Wuhan China Department of Radiation Biology, Fourth Military Medical University, Xi′an, China; Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, Xi′an, China Authors' Affiliations: 1Epigenetics and Progenitor Cells and Human Genetics Programs, 2Ovarian Cancer Program, 3Department of Biostatistics, 4Division of Basic Science, 5Cancer Prevention and Control Program, and 6Division of Population Science, Fox Chase Cancer Center, Philadelphia, Pennsylvania; 7Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland; 8Department of Preventive Medicine and Public Health, Creighton University, Omaha, Nebraska; and 9Laboratory of Developmental Therapeutics, Istituto Regina Elena, Rome, Italy Department of Radiology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China Department of Periodontology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510055, China. Institute of Chinese Medicine, Department of Biology and Department of Biochemistry, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong, People's Republic of China, Hong Kong Jockey Club Institute of Chinese Medicine, Hong Kong Science Park, Shatin, New Territories, Hong Kong, People's Republic of China, and Comparative and Ecological Phytochemistry Section, Department of Systematic and Evolutionary Botany, University of Vienna, Vienna, Austria Nanning Institute of Transfusion Medicine, Nanning Blood Center, Nanning 530007, Guangxi Zhuang Autonomous Region, China. College of Mathematics and Statistics, Institute of Statistical Sciences, Shenzhen Key Laboratory of Advanced Machine Learning and Applications, Shenzhen University, Shenzhen, People's Republic of China Dandong Municipal Center for Disease Control and Prevention Dandong China Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco (Y.Z.). Department of Nephrology, The First People's Hospital of Yunnan Province, The Affiliated Hospital of Kunming University of Science and Technology, Kunming, China Department of Chemistry, Materials Research Laboratory, Marine Biotechnology Center, Department of Molecular, Cellular, and Developmental Biology, Department of Chemical Engineering, and Department of Materials, University of California, Santa Barbara, CA 93106 School of Science and Engineering The Chinese University of Hong Kong Shenzhen Guangdong 518172 China Department of Pharmacology and Toxicology, College of Veterinary Medicine China Agricultural University Beijing 100094 People's Republic of China State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200438, China; MGI Tech, Shenzhen 518083, China Tianjin Key Laboratory for Modern Drug Delivery and High-Efficiency, Collaborative Innovation Center of Chemical Science and Engineering, School of Pharmaceutical Science and Technology, Tianjin University, Tianjin 300072, China iMarker lab, Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, Hangzhou, Zhejiang, China. Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, Hangzhou, Zhejiang, China. Research Center for Industries of the Future, Westlake University, Hangzhou, Zhejiang, China. Institute of Combining Chinese Traditional and Western Medicine, Medical College, Yangzhou University, Jiangsu, Yangzhou 225001, P.R. China Comprehensive Ward, Nanfang Hospital, Southern Medical University, Guangzhou, China National Citrus Engineering Research Center, Citrus Research Institute, Southwest University, Chongqing, China State Key Laboratory of Coordination Chemistry; Collaborative Innovation Center of Advanced Microstructures; School of Chemistry and Chemical Engineering; Nanjing University; Nanjing Merck & Co., Inc., Kenilworth, New Jersey Department of Cell Biology, College of Life Sciences Wuhan University Wuhan China School of Life Sciences, East China Normal University, 500 Dongchuan Rd., Shanghai, P R China National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University; Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences, Jilin University Department of Neurosurgery, Air Force Medical Center, PLA, Beijing 100142, China The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai 200237, China Department of Radiology, Ren Ji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai China Key Laboratory of Crop Heterosis Utilization, State Key Laboratory for Agrobiotechnology, Beijing Key Laboratory of Crop Genetic Improvement, China Agricultural University, Beijing, 100193, China Department of Microbiology and Immunobiology, Harvard Medical School, Boston, Massachusetts, USA College of Agronomy, Henan Agricultural University, Zhengzhou, China MOE Laboratory of Biosystems Homeostasis & Protection, Institute of Microbiology, College of Life Sciences, Zhejiang University, Hangzhou, Zhejiang, China Microbiological Diagnostic Unit Public Health Laboratory, Department of Microbiology and Immunology, University of Melbourne, Victoria 3010, Australia 2Royal Darwin Hospital, Darwin, Northern Territory of Australia, Australia 3Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, Fort Collins, CO, USA Department of Laboratory Medicine, West China Second University Hospital, Sichuan University , Chengdu , China; Key Laboratory of Birth Defects and Related Diseases of Women and Children (Ministry of Education), West China Second University Hospital, Sichuan University , Chengdu , China Center for Craniofacial Molecular Biology, Herman Ostrow School of Dentistry of USC, The University of Southern California, Los Angeles, California 90033, United States Department of Chemistry; State Key Laboratory of Elemento-Organic Chemistry; Nankai University; Tianjin 300071; P. R. China State Key Laboratory of Coordination Chemistry Collaborative Innovation Center of Advanced Microstructures Jiangsu Key Laboratory of Advanced Organic Materials School of Chemistry and Chemical Engineering Nanjing University Nanjing 210023 P. R. China School of Medicine Nankai University Tianjin 300071 China; Department of Ultrasound Tianjin Third Central Hospital Tianjin 300170 China Department of Obstetrics and Gynecology the first Affiliated Hospital of Zhengzhou University Zhengzhou Henan China Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou Medical University, Xuzhou, Jiangsu 221002, P.R. China The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell, University of California, San Francisco; Center for Reproductive Sciences, University of California, San Francisco; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco National Research Institute of Brewing, Higashi-hiroshima, Hiroshima 739-0046, Japan Department of Hematology and Oncology, Zhabei Central Hospital, Shanghai, People’s Republic of China Lilly Research Laboratories, Indianapolis, Indiana 46285, and Departments of Psychiatry, Anatomy and Cell Biology, and Pharmacology, Indiana University Medical School, Indianapolis, Indiana 46202 Center for Clinical Laboratories, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China (mainland) College of Chemistry, Chemical Engineering and Materials Science; Collaborative Innovation Center of Suzhou Nano Science and Technology; Soochow University; Suzhou 215123; P. R. China Center for Device Thermography and Reliability (CDTR), H. H. Wills Physics Laboratory, University of Bristol, Tyndall Avenue, Bristol BS8 1TL, UK Department of Pathology, West China Hospital, Sichuan University Key Laboratory of Chemistry and Engineering of Forest Products School of Chemistry and Chemical Engineering Guangxi Minzu University Nanning China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro‐Products Ningbo University Ningbo China; Key Laboratory of Animal Protein Food Deep Processing Technology of Zhejiang Province, Zhejiang‐Malaysia Joint Research Laboratory for Agricultural Product Processing and Nutrition, College of Food and Pharmaceutical Sciences Ningbo University Ningbo China State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China, Graduate School of the Chinese Academy of Sciences, Beijing 100039, People's Republic of China, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China, Shanghai Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences, Shanghai 200032,... Department of Respiratory, Shengjing Hospital of China Medical University Liaoning, China. Department of General Surgery Jinling Hospital Nanjing China Beijing National Laboratory for Molecular Sciences, Key Laboratory of Bioorganic Chemistry and Molecular Engineering and Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China Key Laboratory of Functional Molecular Solids, Ministry of Education, Anhui Key Laboratory of Molecule-Based Materials, College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241002, China Department of Pediatric Cardiology, First Affiliated Hospital of Jilin University, Changchun, Jilin Province, China Medical Imaging Department; Guangxi Key Clinical Specialty (Medical Imaging Department); Dominant Cultivation Discipline of Guangxi Medical University Cancer Hospital (Medical Imaging Department), Guangxi Medical University Cancer Hospital, Nanning 530021, P. R. China School of Politics and Public Administration, Southwest University of Political Science and Law, Chongqing Municipality Department of Chemical Engineering Stanford University Stanford California 94305 USA College of Life Science, Sichuan University, Sichuan, People's Republic of China State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang, China Department of Pharmacology and Chemical Biology Shanghai Jiao Tong University School of Medicine 280 South Chongqing Road Shanghai 200025 P. R. China School of Marine Science and Biotechnology, Guangxi Key Laboratory for Polysaccharide Materials and Modifications, Guangxi Minzu University, Nanning 530008, PR China Department of Geriatrics, West China Hospital, Sichuan University, Chengdu 610041, China. Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, PR China Gastrointestinal Surgery The Second Affiliated Hospital of Shandong University Jinan 250033 China NHC Key Laboratory of Nuclear Technology Medical Transformation, Mianyang Central Hospital, School of Medicine, University of Electronic Science and Technology of China, Mianyang 621099, Sichuan, China Department of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China The AoYang Cancer Research Institute of Jiangsu University, Zhangjiagang, Suzhou, Jiangsu, China; Department of Clinical Laboratory, Children’s Hospital of Soochow University, Suzhou, Jiangsu, China China State Institute of Pharmaceutical Industry; Shanghai; China Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, S7N 5E3, Canada Department of Ophthalmology, Liaocheng People’s Hospital, Liaocheng, Shandong, China (mainland) *Stomatology, Department of Neurology, Traditional Chinese Medical Hospital of Zhuji, Zhuji, Zhejiang 311800, P.R. China Beijing Jishuitan Hospital, The 4th Clinical Medical College of Peking University, Beijing, China (mainland) Fox Chase Cancer Center, 7701 Burholme Avenue, Philadelphia, PA 19111 Chengdu Institute of Biology Chinese Academy of Sciences Chengdu P. R. China State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210023, P. R. China Department of Obstetrics and Gynecology Qilu Hospital Shandong University Ji’nan, Shandong China Department of Infection Disease Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi Department of Pharmacology, School of Pharmacy, Guangxi Medical University, Nanning 530021, China. [email protected] Oncology Department, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China State Key Laboratory of Food Science and Technology and College of Food Science, Nanchang University Advanced Environmental Biotechnology Centre (AEBC), Nanyang Environment and Water Research Institute (NEWRI), Nanyang Technological University , Singapore Chengdu Institute of Biology Chinese Academy of Sciences Chengdu 610041 China Department of Laboratory Medicine, West China Second University Hospital, Sichuan University, Chengdu, China; Key Laboratory of Birth Defects and Related Diseases of Women and Children, Sichuan University, Ministry of Education, Chengdu, China Zhangjiagang Center for Disease Control and Prevention Zhangjiagang China Chengdu Institute of Biology Chinese Academy of Sciences Chengdu P. R. China; University of Chinese Academy of Sciences Beijing P. R. China State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China. National Laboratory of Animal Schistosomiasis Control, Key Laboratory of Animal Parasitology Ministry of Agriculture, Shanghai Veterinary Research Institute of CAAS, Shanghai 200232, China. State Key Laboratory of Bioreactor Engineering East China University of Science and Technology Shanghai P. R. China Southwest Agricultural University, Chongqing Beibei, 400716, China.; Beijing Institute of Genomics of Chinese Academy of Sciences, Beijing Genomics Institute, Beijing Proteomics Institute, Beijing 101300, China.; James D. Watson Institute of Genome Sciences of Zhejiang University, Hangzhou Genomics Institute, Key Laboratory of Genomic Bioinformatics of Zhejiang Province, Hangzhou 310008, China.; University of Washington Genome Center, Department of Medicine, University of Washington, Seattle, WA 98195, USA. Department of Radiology Renji Hospital School of Medicine Shanghai Jiao Tong University No. 160, Pujian Road, Pudong District Shanghai 200127 China; College of Health Science and Technology Shanghai Jiao Tong University School of Medicine No. 227, Chongqingnan Road Huangpu District Shanghai 200025 China Bioinformatics and Biostatistics Facility, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, Pennsylvania 19111, United States School of Chemistry Engineering; Northeast Electric Power University; Jilin 132012; China Department of Epidemiology, Biostatistics and Occupational Health; McGill University; Montreal Canada Department of Gastrointestinal Surgery and and Central Laboratory, Affiliated Changzhou No.2 People’s Hospital of Nanjing Medical University , Changzhou , China Department of Microbial and Biochemical Pharmacy, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China Department of Anesthesiology, The First People's Hospital of Jinan, Jinan, Shandong Province, China Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences Chengdu 610041 P.R. China National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun 130012, PRChina Herman Ostrow School of Dentistry of USC, Center for Craniofacial Molecular Biology, University of Southern California, 2250 Alcazar Street, Clinical Science Annex Room 142, Health Sciences Campus, Los Angeles, California 90089-0641, United States Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, Pharmacy School of Xuzhou Medical University, Xuzhou, Jiangsu 221004, China Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, School of Chemistry and Molecular Engineering, East China Normal University, Dongchuan Road 500, Shanghai 200241, P. R. China Life Science and Technology School, Lingnan Normal University, Zhanjiang, China Departments of Laboratory Medicine, Zhongshan Hospital Fudan University Shanghai China Department of Pediatrics, Beijing Tongren Hospital, Capital Medical University, No 2, Xihuan South Road, Yizhuang Economic and Technological Development Zone, Beijing 100176, China Institute of Pharmaceutics College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 P. R. China Department of Oncology, Yixing Hospital Affiliated to Medical College of Yangzhou University, Yixing, Jiangsu, China; Institute of Combining Chinese Traditional and Western Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu, China *Department of Biophysics, Center for Integrative Physiology and Molecular Medicine, School of Medicine, Saarland University, 66421 Homburg, Germany; Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas Nanyang Environment and Water Research Institute (NEWRI), Nanyang Technological University, 50 Nanyang Avenue, Block N1-B3b-29, Singapore 639798, Singapore E-mail: [email protected] Department of Rheumatology, Shenzhen Futian Hospital for Rheumatic Diseases, Shenzhen, Guangdong, China Department of Neurosurgery Union Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China Hubei Key Laboratory of Cell Homeostasis, College of Life Sciences at Wuhan University, Wuhan 430072, China The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Lab of Ophthalmology, Chongqing Eye Institute, Chongqing, People's Republic of China. Department of Pathology, School of Basic Medical Sciences, Peking University, Beijing, China (YZ,PP,LY,MS,PH,NN,MAM,JG) Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing, China Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China, and State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, China Department of Pediatric Surgery, Capital Institute of Pediatrics, Beijing, People’s Republic of China College of Food Science, Northeast Agricultural University Department of Chemistry Hong Kong Baptist University Kowloon Tong Hong Kong SAR Hong Kong State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai 200433, China;Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai 200000, China. Department of Computer Science, University of Houston, Houston, TX 77024, USA. [email protected] School of Materials Science and Engineering and ‡School of National Defence Science and Technology, Southwest University of Science and Technology, Mianyang, 621010, People’s Republic of China Department of Genetics Inner Mongolia Maternal and Child Care Hospital Hohhot Inner Mongolian Autonomous Region China West China Hospital, Sichuan University; Department of Geriatrics; No. 37, Guo Xue Xiang Chengdu Sichuan China 610041 Department of Chemistry, Cleveland State University, Cleveland, OH 44115. Departments of Medicine and Pediatrics, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 Department of Obstetrics, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210036, P.R. China Department of Orthopedics, General Hospital of Jincheng Anthracite Mining Group Co., Ltd., Jincheng, China From the Magee Womens Research Institute (R.E.G., J.R., E.S., A.R., V.E.K., C.A.H.), Pittsburgh, Pa; Departments of Environmental and Occupational Health (R.E.G., V.E.K.), Obstetrics, Gynecology, and Reproductive Sciences (A.J., C.A.H.), Dental Public Health and Information Management (N.M.), and Epidemiology (G.F.H.), University of Pittsburgh, Pa; and Cell and Tissue Biology (Y.Z.), University of California San Francisco. Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China. School of Information Engineering, Hubei University of Economics, Wuhan 430205, China Department of Radiation Medicine and Protection, Faculty of Preventive Medicine, Airforce Medical University, Xi'an, Shaanxi 710032, P.R. China Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, P.R China 2Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, Philadelphia, Pennsylvania. Department of Oncology, Zhangjiagang Ao Yang Hospital, Zhangjiagang, Jiangsu, China College of Geography and Tourism, Shaanxi Normal University, Xi'an 710119, China. Centers for Disease Control and Prevention, Fort Collins, Colorado, USA Department of Neurosurgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, 321 Zhongshan Road, Nanjing 210008, China ObGyn, Reproductive Sciences, University of California San Francisco, 35 Medical Center Way, San Francisco, California 94143, USA. Fisheries College, Guangdong Ocean University, Zhanjiang 524088, China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy Pharmacy School of Xuzhou Medical University Xuzhou City 221004 Jiangsu Province P. R. China 2Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, Philadelphia, PA 19111, U.S.A. Department of Chemistry and Chemical Biology, Indiana University-Purdue University Indianapolis, 402 N. Blackford St., LD326, Indianapolis, Indiana 46202, United States Gilead Sciences Foster City California Department of Anesthesiology, Beijing Jishuitan Hospital, Beijing, China State Key Laboratory of Bioreactor Engineering, Department of Food Science and Technology, School of Biotechnology, East China University of Science and Technology, Shanghai 200237, People’s Republic of China Key Laboratory of Functional, Ministry of Education, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, 241002, China Department of Hematology, The First Affiliated Hospital of Jiaxing University, Jiaxing, Zhejiang 314000, P.R. China Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland, USA Endocrinology and Metabolism Department, Beijing Hospital of the Ministry of Health, Dongdan Dahua, Road Number One, Beijing 100730, China Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Shatin, Hong Kong, People’s Republic of China, Bioengineering Graduate Program, Department of Chemical Engineering, and Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People’s Republic of China, and State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People’s Republic... Department of Medical Oncology Affiliated Tumour Hospital of Guangzhou Medical University Guangzhou China Department of Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA. College of Life Science, Sichuan University, Chengdu 610064, PR China State Key Laboratory of Bioreactor Engineering, School of Bioengineering, East China University of Science and Technology, Shanghai, People's Republic of China. The Key Laboratory of Bioorganic Chemistry and Molecular Engineering and the Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China 2Department of Laboratory Medicine, Zhongshan hospital, Fudan University. Department of Pharmaceutical Sciences; Zunyi Medical College Zhuhai Campus; Zhuhai Guangdong China Beijing National Laboratory for Molecular Sciences, the Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China Optoelectronics System Laboratory, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China; College of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Sciences, Beijing 100049, China Department of Orthopaedics, Luotian People's Hospital, Luotian Hubei 438600, PR China. [email protected] Department of Radiology , Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China State Key Laboratory of Chemo/Biosensing and Chemometrics College of Biology College of Chemistry and Chemical Engineering Key Laboratory for Bio‐Nanotechnology and Molecular Engineering of Hunan Province Hunan University Changsha 410082 P. R. China Key Laboratory for Soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and Technology Nanjing 210094 China; School of Energy and Chemical Engineering/Center for Dimension Controllable Organic Frameworks Ulsan National Institute of Science and Technology (UNIST) 50 UNIST Ulsan 44919 South Korea Advanced Water Management Centre (AWMC), The University of Queensland, St Lucia, Brisbane, QLD 4072, Australia Department of Chemistry, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States Graduate School, Beijing University of Chinese Medicine, Beijing, China Department of Gastroenterology, No 1 Hospital Affiliated to Yangtze University, China Australian Research Council Centre of Excellence for Functional Nanomaterials, Advanced Water Management Centre, Brisbane Surface Analysis Facility, and Division of Chemical Engineering, University of Queensland, QLD 4072, Brisbane, Australia Center for Nanophase Materials Sciences and ‡Materials Science and Technology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37831, United States Department of Intensive Care Unit West China Hospital Sichuan University Chengdu Sichuan PR China *Department of Toxicology, Anhui Medical University, Hefei 230032, China;; †Laboratory of Environmental Toxicology, Hefei 230032, China; and Department of Nephrology, The First People’s Hospital of Yunnan Province/The Affiliated Hospital of Kunming University of Science and Technology, Kunming, Yunnan, China Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China Institute of Medical Biology, Chinese Academy of Medical Science & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on severe Infectious Disease Kunming China College of Medical, Hebei University of Engineering, Handan 056002, China Shandong Provincial Institute of Dermatology and Venereology Shandong First Medical University and Shandong Academy of Medical Sciences Jinan China State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing, P. R. China School of Chemistry and Chemical Engineering, Guangxi University for Nationalities, Guangxi Colleges and Universities, Nanning 530008, China Authors' Affiliations: 1Department of Molecular Cell Biology and Toxicology, Jiangsu Key Lab of Cancer Biomarkers, Prevention & Treatment, Cancer Center; School of Public Health, Nanjing Medical University, Nanjing; 2Department of Pathology, Nantong Cancer Hospital, Nantong; 3Department of Oncology, Yixing Hospital, Yixing, Jiangsu Province; 4Laboratory of Biological Cancer Therapy, Xuzhou Medical College, Xuzhou, Jiangsu Province, People's Republic of China; 5Department of Dermatology and Skin Science, Jack Bell Research Centre, Vancouver Coastal Health Research Institute, University of British Columbia, Vancouver, British Columbia, Canada; 6Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim; and 7Cancer Clinic, Levanger Hospital, Nord-Trøndelag Health Trust, Levanger, Norway Department of Radiology Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 P. R. China College of Materials Science and Technology Jiangsu Key Laboratory of Materials and Technology for Energy Conversion Nanjing University of Aeronautics and Astronautics 210016 Nanjing P.R. China), Fax College of Chemistry and Materials Science, The Key Laboratory of Electrochemical Clean Energy of Anhui Higher Education Institutes, Anhui Provincial Engineering Laboratory for New-Energy Vehicle Battery Energy-Storage Materials, Anhui Normal University, No. 189 Jiuhua South Road, Wuhu, 241002, China Department of Molecular Genetics, College of Medicine, University of Illinois at Chicago, Chicago, Illinois 60607-7170; Department of Geriatrics, West China Hospital and National Clinical Research Center for Geriatrics, Sichuan University, Chengdu, Sichuan Province, China. Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology Chinese Academy of Sciences Chengdu P. R. China O. Genbacev and Y. Zhou, Department of Stomatology, University of California, San Francisco, CA 94143–0512, USA.; J. W. Ludlow, Department of Biochemistry and Biophysics, University of Rochester, Cancer Center, Rochester, NY 14642, USA.; S. J. Fisher, Departments of Stomatology; Obstetrics, Gynecology and Reproductive Sciences; Pharmaceutical Chemistry; and Anatomy, University of California, San Francisco, CA 94143–0512, USA. BGI-Shenzhen, Shenzhen 518083, China. Nanjing Institute of Environmental Science, Ministry of Environmental Protection, Nanjing 210042, China. State Environmental Protection Key Laboratory of Soil Environmental Management and Pollution Control, Nanjing 210042, China. Department of Astronautics and Mechanics, Harbin Institute of Technology, Harbin 150001, China East China University of Science and Technology (ECUST) 1 State Key Laboratory of Chemical Engineering, , Shanghai 200237, China From the *Key Laboratory for Major Obstetric Diseases of Guangdong Province, Key Laboratory of Reproduction and Genetics of Guangdong Higher Education Institutes, Department of Obstetrics and Gynecology, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou; †The First People’s Hospital of Chenzhou, Chenzhou; and ‡Biomedicine Research Center and Department of Surgery, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, China. Department of General Surgery The Second Xiangya Hospital Central South University Changsha Hunan China Department of Infection Disease Center, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, China Ministry of Ecology and Environment Peoples Republic of China, Nanjing Institute of Environmental Science, No. 8, Jiangwang Miao Street, Nanjing 210042, China; State Environmental Protection Key Laboratory of Soil Environmental Management and Pollution Control, Nanjing 210042, China Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada Central Laboratory Renji Hospital affiliated to Shanghai Jiao Tong University School of Medicine Shanghai 200127 P. R. China Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Medicine, Medical College of Wisconsin, Milwaukee Department of Physics, ‡Department of Chemistry and Biochemistry, §Department of Chemical and Biomedical Engineering, ∥National High Magnetic Field Laboratory, and ⊥Materials Science Program, Florida State University, Tallahassee, Florida 32306, United States Department of Medical Affairs, First Hospital of Changsha, Changsha 410005. [email protected]. Department of Agricultural and Biological Engineering, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA School of Chemical and Environmental Engineering, Shanghai Institute of Technology, Shanghai 201418, P. R. China Demonstration Center of Biological Experimental Teaching, Wenzhou Medical University, Wenzhou 325000, China. School of Medicine, Nankai University, Tianjin300071, China; Department of Ultrasound, Tianjin Third Central Hospital, Tianjin300170, China American Board of Anesthesiology Raleigh NC USA Department of Respiratory and Critical Care Medicine Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China Natural and Built Environments Research Centre, School of Natural and Built Environments, University of South Australia, Mawson Lakes, South Australia 5095, Australia Department of Gastrointestinal Surgery, The Affiliated Changzhou No. 2 People’s Hospital of Nanjing Medical University, Changzhou, Jiangsu, China Department of Colorectal and Anal Surgery, Zhongnan Hospital of Wuhan University, Wuhan, Hubei, P. R. China; Clinical Center of Intestinal and Colorectal Diseases of Hubei Province, Wuhan, Hubei, P. R. China; Key Laboratory of Intestinal and Colorectal Diseases of Hubei Province, Wuhan, Hubei, P. R. China Orthopedic Surgery Renmin Hospital of Wuhan University, Hubei General Hospital Wuchang District, Wuhan China Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, People’s Republic of China Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou 510055, China; Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou 510055, China State Key Laboratory of Food Science and Technology; Nanchang University; Nanchang 330047; China The Key Laboratory of Bioorganic Chemistry and Molecular Engineering and the Key Laboratory of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China, and Institute of Polymer Optoelectronic Materials and Devices, South China University of Technology, Key Lab of Specially Functional Materials of Ministry of Education, Guangzhou 510640, China Nano Electrochemistry Laboratory College of Engineering University of Georgia Athens Georgia School of Public Health, The Key Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education Guizhou Medical University Guiyang China Institute of Medical Biology, Chinese Academy of Medical Science & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Disease, Kunming 650118, China Division of HIV and Sexual Transmitted Viral Vaccine; National Institutes for Food and Drug Control; Beijing China College of Veterinary Medicine, China Agricultural University, Beijing, People's Republic of China Department of Critical Care Medicine, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510150, P.R. China From the Center for Translational Medicine, Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA (C.J.T., A.C., A.G.V., B.P.W., J.H., J.I., J.I.G., J.K.C., E.G., W.J.K.); and Department of Biostatistics and Bioinformatics, Fox Chase Cancer Center, Philadelphia, PA (Y.Z.). Institute of Polymer Optoelectronic Materials and Devices, South China University of Technology, and Key Laboratory of Specially Functional Materials, Ministry of Education, Guangzhou 510640, China; Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China Key Laboratory of Modern Toxicology of Shenzhen, Shenzhen Medical Key Discipline of Health Toxicology (2020-2024), Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, Guangdong, People’s Republic of China Infinitus (China) Company Ltd., China Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes; School of Materials Science and Technology; China University of Geosciences; Beijing 100083; PR China Life Science and Technology School Lingnan Normal University Zhanjiang 524048 China Department of Central Lab Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai China Division of Drug and Cosmetics Inspection, Center for Food and Drug Inspection, China Food and Drug Administration, No.11 Fa Hua Nan Li, Dongcheng District, Beijing, 100061, China. Institute of Agriculture Products Processing Science and Technology, Sichuan Academy of Agriculture Science, Chengdu 610039, China Center for Reproduction and Genetics, Nanjing Medical University Affiliated Suzhou Hospital, SuZhou, Jiangsu, China Department of Rheumatology General Hospital of Ningxia Medical University Yinchuan China CAS Key Laboratory of Engineering Plastics, CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences (CAS), Beijing 100190, China; University of Chinese Academy of Sciences, Beijing 100049, China National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University, Changchun, China.; Key Laboratory for Molecular Enzymology and Engineering, The Ministry of Education, School of Life Sciences, Jilin University, Changchun, China. Department of Neurosurgery, Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing China Department of Molecular Pathology, The University of Texas M. D. Anderson Cancer Center, Houston; Department of General Surgery, Jinling Hospital, Medical School of Nanjing University , Nanjing , China Department of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Capital Medical University, Beijing, China; Beijing Key Laboratory for Tumor Invasion and Metastasis, Capital Medical University, Beijing, China Beijing National Laboratory for Molecular Sciences (BNLMS), the Key Laboratory of Bioorganic Chemistry and Molecular Engineering, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China Department of Neurology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou325035, China. State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University , Shanghai , China; Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai Institute for Biomedical and Pharmaceutical Technologies , Shanghai , China Department of Operation Room, Hiser Hospital, Shibei District, Qingdao, Shandong, China. State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China, and Shanghai Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences, Shanghai 200032, People's Republic of China Department of Pediatrics, The First Hospital of Jilin UniversityChangchunP.R. China Department of Nephrology, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, China; Department of Nephrology, Shandong Provincial Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China From the American Board of Anesthesiology, Raleigh, North Carolina (Y.Z., H.S., M.T.K., T.W., A.E.H., D.O.W.); Department of Anesthesiology, Medical College of Wisconsin, Milwaukee, Wisconsin (C.A.L.); and Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota (M.T.K., D.O.W.). Department of Dermatology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China Key Laboratory of Functional Molecular Solids, Ministry of Education, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, 241002, China fDepartment of Stomatology, University of California at San Francisco, San Francisco, California 94143 Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, P. R. China Department of Pharmacy the First Hospital of Lanzhou University Lanzhou China Division of Basic Sciences, Fox Chase Cancer Center, Philadelphia, PA 19111 Department of Obstetrics and Gynecology (C.Z., J.-n.X., Y.Z., H.-x.Y., Y.-f.Z., Q.X.), Peking University First Hospital, Beijing, 100034, P. R. China BGI-Shenzhen, 518083, Shenzhen, China Department of Geriatrics, Tianjin Medical University General Hospital Department of Oncology Yixing People's Hospital Yixing China Department of Radiology Peking University Third Hospital Haidian District Beijing P.R. China Department of Dermatology The First Affiliated Hospital of Xi'an Jiaotong University Xi'an China The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute, Chongqing, P. R. China; Department of Ophthalmology, Yongchuan Hospital, Chongqing Medical University, Chongqing, China. College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, China Materials Science and Engineering Program; Florida State University; Tallahassee; USA Intensive Care Unit, West China Hospital, Sichuan University, Chengdu, China. Department of Microbial and Biochemical Pharmacy, School of Pharmaceutical Sciences, Sun Yat-Sen University, Guangzhou 510006, China Jilin Province Key Laboratory of Animal Embryo Engineering, College of Animal Science and Veterinary Medicine, Jilin University, Changchun, People's Republic of China. Department of Thoracic Surgery The First Hospital of Jilin University Changchun China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou China The Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA. Electronic address: [email protected]. Department of Radiology, Sihong County Sub-Jinting Hospital, Suqian, Jiangsu, China College of Mathematics and Statistics, Institute of Statistical Sciences, Shenzhen University, Shenzhen, China Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Key Laboratory of Bio-Resource and Eco-Environment of Ministry of Education, College of Life Sciences, Sichuan University, Chengdu 610065, Sichuan, China Department of Urology, Hebei Province of Chinese Medicine, Shijiazhuang City, Hebei Province, China Department of Pharmacy, The First Hospital of Lanzhou University, Lanzhou, China State Key Laboratory for Biology of Plant Diseases and Insect Pests, Institute of Plant Protection, Chinese Academy of Agricultural Sciences, Beijing 100193, China State Key Lab for Medical Genomics and Samuel Waxman Cancer Research Foundation Lab, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Second Medical University, 197 Rui Jin Road II, Shanghai 200025, China; Chinese National Human Genome Center at Shanghai, 351 Guo Shou Jing Road, Pudong, Shanghai 201203, China; State Key Lab for Genetic Engineering, FuDan University, 220 Han Dan Road, Shanghai 200433, China; Section of Infectious Disease, Department of Medicine, Baylor College of Medicine... Key Laboratories of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, P. R. China Department of Radiology, Ren Ji Hospital, School of Medicine Shanghai Jiao Tong University Shanghai P.R. China Department of Chemistry, Fudan University, Shanghai 200433, China State Key Laboratory of Developmental Biology of Freshwater Fish, College of Life Science, Hunan Normal University, Changsha 410081, Hunan, P. R. China Faculty of Preventive Medicine, Department of Radiation Biology Fourth Military Medical University Xi′an Shaanxi People's Republic of China Department of Anesthesiology, Beijing Jishuitan Hospital, Peking University Fourth School of Clinical Medicine, Beijing 100035, China Department of Radiology, Peking University Third Hospital, 49 North Garden Road, Haidian District, Beijing 100191, China Institute of Polymer Optoelectronic Materials and Devices, South China University of Technology, and Key Laboratory of Specially Functional Materials, Ministry of Education, Guangzhou 510640, China, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials (Ministry of Education), Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), and College of Chemistry, Nankai University, Tianjin 300071, P. R. China Department of Clinic, Medicine School, Changsha Social Work College, Changsha, Hunan 410004, P.R. China Optoelectronic System Laboratory, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China; School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 100049, China Beijing Engineering Laboratory of Main Crop Biotechnology Breeding Beijing Solidwill Sci‐Tech Co. Ltd. Beijing China Central Laboratory, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China; State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200032, China Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Shatin, Hong Kong, People’s Republic of China, and School of Biomedical Sciences, The Chinese University of Hong Kong, Shatin, Hong Kong, People’s Republic of China School of Science and Engineering The Chinese University of Hong Kong Shenzhen Guangdong 518172 P. R. China Vaccine and Infectious Disease Organization (VIDO), University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E3, Canada Neuroscience Discovery Research and Bioresearch Technologies and Proteins, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA. State Key Laboratory of Superlattices and Microstructures, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China Department of Neuroimmunology, Research Institute of Environmental Medicine, Nagoya University Vaccine and Infectious Disease Organization—International Vaccine Center, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Vaccinology & Immunotherapeutics Program, School of Public Health, University of Saskatchewan, Saskatoon, Saskatchewan, Canada; Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, Canada State Key Laboratory of Genetic Engineering, School of Life Sciences, Fudan University, Shanghai, 200438, China; Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, Shanghai, 201203, China Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, College of Chemistry, Peking University, Beijing 100871, PR China Department of Urology, Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China Departments of Neuroscience, Medicine, Pharmacology and Molecular Sciences, and Psychiatry and Behavioral Sciences, The Johns Hopkins University School of Medicine, Baltimore, MD 21205 Department of Obstetrics, The First Affiliated Hospital of Nanjing Medical University Biophysics, Center for Integrative Physiology and Molecular Medicine, School of Medicine Saarland University Homburg Germany Department of Chemistry and Biochemistry Florida State University Tallahassee FL 32306 USA Clinical Graduate Department, Graduate School of Beijing University of Chinese Medicine, Beijing, China Department of Radiology, Department of Anesthesiology, Renji Hospital Shanghai Jiao Tong University School of Medicine Shanghai China Department of Dermatology, First Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China 3Molecular Therapeutics Program, Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania.; 7Biostatistics and Bioinformatics Facility, Institute for Cancer Research, Fox Chase Cancer Center, Philadelphia, Pennsylvania. Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing 100034, People's Republic of China National Research Institute of Brewing, Higashihiroshima, Hiroshima, Japan Division of Nephrology, Affiliated Hospital of Jiangsu University, Jiangsu University, Zhenjiang, China; Shanghai-MOST Key Laboratory of Health and Disease Genomics, Chinese National Human Genome Center at Shanghai, 250 Bi Bo Road, Shanghai 201203, China.;School of Life Science/Institutes of Biomedical Sciences, Fudan University, 220 Han Dan Road, Shanghai 200433, China. Advanced Environmental Biotechnology Centre, Nanyang Environment and Water Research Institute, Nanyang Technological University, 1 CleanTech Loop, 637141, Singapore Merck & Co., Inc., Kenilworth, NJ. Departments of Medicine Department of Epidemiology, Fujian Province Tumor Hospital, Fuzhou 350014, China. Department of Colorectal and Anal Surgery, Zhongnan Hospital of Wuhan University; Clinical Center of Intestinal and Colorectal Diseases of Hubei Province; Hubei Key Laboratory of Intestinal and Colorectal Diseases (Zhongnan Hospital of Wuhan University); Quality Control Center of Colorectal and Anal Surgery of Health and Family Planning Commission of Hubei Province School of Medicine Tianjin Key Laboratory for Modern Drug Delivery & High-Efficiency Collaborative Innovation Center of Chemical Science and Engineering School of Pharmaceutical Science and Technology Tianjin University Tianjin 300072 P. R. China 0 Howard Hughes Medical Institute and Department of Medicine, Johns Hopkins University School of Medicine, 733 North Broadway Street, Baltimore, Maryland 21205 Tianjin Medical University General Hospital Tianjin Medical University Cancer Institute and Hospital School of Basic Medical Sciences School and Hospital of Stomatology Tianjin Medical University Tianjin China Department of Interventional Radiology State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, 310014, P. R. China Chemical Biology Research Center at School of Pharmaceutical Sciences, Wenzhou Medical University, 1210 University Town, Wenzhou, Zhejiang 325035, China College of Environment, Hohai University, Nanjing 210098, China. Department of Oncology, AoYoung Hospital, Zhangjiagang, Jiangsu 215617, China Laboratory of the Biology of Addictive Diseases ; The Rockefeller University; New York New York JILA, National Institute of Standards and Technology, Department of Physics, University of Colorado 2 , Boulder, Colorado 80309-0440, USA Department of General Surgery, Center for Inflammatory Bowel Diseases, Jinling Hospital Medical School of Nanjing University 305 East Zhongshan Road 210002 Nanjing China Fox Chase Cancer Center, Philadelphia, PA 19111 Department of Molecular Biology, Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College, Kunming, China 1 Mary S. Easton Centre for Alzheimer’s Disease Research at UCLA, 10911 Weyburn Ave., #200, Los Angeles, CA, 90095, USA Department of Stomatology, Xinqiao Hospital, Third Military Medical University, Chongqing, China,1 Department of Electrical and Computer Engineering, National University of Singapore, 4 Engineering Drive 3, 117576, Singapore Wenzhou Key Laboratory of Sanitary Microbiology, Wenzhou Medical University National Key Laboratory of Crop Genetic Improvement, National Center of Plant Gene Research (Wuhan), Huazhong Agricultural University, Wuhan 430070, China a University of Southern California Department of Respiratory Medicine, Shanghai First Hospital, Shanghai Jiao Tong University, Shanghai 200080, China Contribution from the Institute for Collaborative Biotechnologies, California NanoSystems Institute and the Materials Research Laboratory, University of California, Santa Barbara, California 93106 Xin'anjiang Forest Center of Jiande, Hangzhou 311600, China. College of Chemistry and Chemical Engineering Jiangxi Inorganic Membrane Materials Engineering Research Centre Jiangxi Normal University Nanchang 330022 China School of Energy and Power Engineering, Xi'an Jiaotong University, Xi'an 710049, China. [email protected] Institute of Neurology, Fudan University Huashan Affiliated Hospital, Fudan University, Shanghai, China Department of Chemical Engineering Stanford University Stanford CA 94305 USA 1Guangdong Key Laboratory of Chiral Molecule and Drug Discovery, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, Guangdong, China. National Research Institute of Brewing, Higashi-Hiroshima, Japan National Institute of Biological Sciences, Beijing, 102206, China. Department of Cardiology,Renmin Hospital of Wuhan University,Wuhan,China; Institute of Model Anima,Wuhan University,Wuhan,China Land Consolidation and Rehabilitation Center, Ministry of Natural Resources, Beijing 100035, China. Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, Maryland School of Electronics and Information Engineering, Soochow University, Suzhou, Jiangsu, China Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, P. R. China Beatson Institute for Cancer Research, Glasgow, UK Department of Orthopaedics, People's Hospital of Luotian County, Luotian Hubei, 438600, P.R. China. [email protected] Key Laboratory of Construction Hydraulic Robots, Anhui Higher Education Institutes, Tongling University, Tongling 244061, China JILA, University of Colorado Boulder 2 , 440 University Ave., Boulder, Colorado 80302, USA Authors' Affiliations: 1Department of Pathology, School of Basic Medical Sciences, Peking University; 2Novogene Bioinformatics Institute, Beijing; 3Shantou University Medical College, Shantou, China; 4Department of Medicine, Cedars-Sinai Medical Center, UCLA School of Medicine; 5Department of Pathology, UCLA Medical Center, Los Angeles, California; and 6Cancer Science Institute and National Cancer Institute, National University of Singapore, Singapore; Authors' Affiliations: 1Department of Pathology, School of Basic Medical Sciences, Peking University; 2Novogene Bioinformatics Institute, Beijing; 3Shantou University Medical College, Shantou, China; 4Department of Medicine, Cedars-Sinai Medical Center, UCLA School of Medicine; 5Department of Pathology, UCLA Medical Center, Los Angeles, California; and 6Cancer Science Institute and National Cancer Institute, National University of Singapore, Singapore; Authors' Affiliations: 1Department of Pathology, School of Basic Medical Sciences, Peking University; 2Novogene Bioinformatics Institute, Beijing; 3Shantou University Medical College, Shantou, China; 4Department of Medicine, Cedars-Sinai Medical Center, UCLA School of Medicine; 5Department of Pathology, UCLA Medical Center, Los Angeles, California; and 6Cancer Science Institute and National Cancer Institute, National University of Singapore, Singapore Key Laboratories of Bioorganic Chemistry and Molecular Engineering and of Polymer Chemistry and Physics of Ministry of Education, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, College of Chemistry, Peking University, Beijing 100871, China, and Institute of Polymer Optoelectronic Materials and Devices, South China University of Technology, and Key Lab of Specially Functional Materials, Ministry of Education, Guangzhou 510640, China 3Fox Chase Cancer Center, Philadelphia, Pennsylvania. Department of Hematology and Oncology Kunming Children's Hospital Kunming Yunnan China; Kunming Medical University Kunming Yunnan China Department of Pharmacy, the First Hospital of Lanzhou University, Lanzhou, China, Department of Otolaryngology, Union Hospital, Tongji Medical College, Wuhan, Hubei 430000, P.R. China Breast Disease Center, Southwest Hospital, Third Military Medical University, Chongqing 400038, China Department of Neurology University of California Los Angeles Los Angeles CA USA Chengdu Institute of Biology, Chinese Academy of Sciences Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, China; Guangdong Key Laboratory for Dental Disease Prevention and Control, Sun Yat-sen University, Guangzhou, China State Key Laboratory of Bioreactor Engineering, School of Bioengineering, East China University of Science and Technology, Shanghai, 200237, China Gilead Sciences, Inc. Foster City California USA State Key Laboratory of Bioreactor Engineering East China University of Science and Technology 130 Mei‐Long Road, P. O. Box 309# Shanghai 200237 P. R. China Institute of Combining Chinese Traditional and Western Medicine, Medical College, Yangzhou University, Yangzhou, Jiangsu, China The Laboratory of the Biology of Addictive Diseases The Rockefeller University New York New York College of Life Sciences Wuhan University Wuhan China National Institute of Biological Sciences, Beijing 102206, China; and; College of Life Science, Beijing Normal University, Beijing 100875, China The Gastroenterology Tumor and Microenvironment Laboratory Department of Gastroenterology The First Affiliated Hospital of Chengdu Medical College Chengdu Medical College Chengdu People's Republic of China From the American Board of Anesthesiology, Raleigh, North Carolina (H.S., D.O.W., A.M., Y.Z., D.J.C., M.T.K.), the Department of Anesthesiology and Perioperative Medicine, Mayo Clinic, Rochester, Minnesota (D.O.W., M.T.K.), the Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University, Stanford, California (A.M.), and the Department of Anesthesiology, Perioperative and Pa Institute of Medical Biology, Chinese Academy of Medical Science & Peking Union Medical College, Yunnan Key Laboratory of Vaccine Research and Development on severe Infectious Disease, Kunming, China Shanghai Centennial Scientific, Shanghai, China Key Laboratory for Soft Chemistry and Functional Materials of Ministry of Education Nanjing University of Science and Technology Nanjing 210094 P. R. China University of Michigan, Ann Arbor Anesthesiology Department Beijing Jishuitan Hospital Beijing China School of Biomedical Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai200240, P. R. China Department of Obstetrics and Gynecology & Carson International Cancer Research Center, Shenzhen University General Hospital and Shenzhen University Clinical Medical Academy, Xueyuan Road 1098, 518055 Shenzhen, China State Key Laboratory of Tribology; Tsinghua University; Beijing 100084; China; Guangdong Provincial Key Laboratory of Optomechatronics Department of Center for Clinical Laboratories, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou Province, China Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes, National Laboratory of Mineral Materials, School of Materials Science and Technology, China University of Geosciences, Beijing 100083, China School of Science and Engineering; The Chinese University of Hong Kong; Shenzhen; China Department of General Surgery, Yantai Mountain Hospital, Yantai, Shandong 264000, P.R. China Engineering Research Centre of Prevention and Control for Clinical Medication Risk, Lanzhou 730000, China; Department of Pharmacy, The First Hospital of Lanzhou University, Lanzhou 730000, China Institute of Translational Medicine, Medical College, Yangzhou University, Yangzhou 225001, PR China; Traditional Chinese Medicine Administration, The Key Laboratory of Syndrome Differentiation & Treatment of Gastric Cancer of the State Administration of Traditional Chinese Medicine, Yangzhou, 225001, PR China; Department of Oncology, Yixing Hospital Affiliated to Medical College of Yangzhou University, Yixing, Jiangsu, 214200, PR China Biostatistics Department, Fox Chase Cancer Center, Philadelphia, PA, USA Department of Hepatobiliary Surgery Affiliated Drum Tower Hospital, Medical School of Nanjing University Nanjing China Department of Radiology, Renji Hospital, School of Medicine Shanghai Jiaotong University Shanghai China Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, People’s Republic of China The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi’an Jiaotong University, Xi’an 710049, P. R. China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi’an Jiaotong University, Xi’an 710049, P. R. China Life Sciences Institute and Innovation Center for Cell Signaling Network, Zhejiang University, Hangzhou, Zhejiang 310058, China; Danish Regenerative Engineering Alliance for Medicine, Department of Biomedicine, Aarhus University, Aarhus, Denmark. School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen, Guangdong 518172, China Department of Radiation Oncology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China , Hefei 230031 , Anhui Province , China Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, SK, Canada Department of Oncology, Yixing Hospital Affiliated to Medical College of Yangzhou University, Yixing, Jiangsu 214200, P.R. China Department of Preventive Medicine, Zunyi Medical College, Zunyi, Guizhou, China Department of Chemistry, School of Chemistry and Materials Science Liaoning Shihua University 113001 Fushun People's Republic of China School of Medicine, Jiangsu University, Zhenjiang, China. Department of General Surgery,Second Xiangya Hospital,Central South University,Changsha,P.R. China State Key Laboratory of Bioreactor Engineering, ECUST, Shanghai 200237, China. From the American Board of Anesthesiology, Raleigh, North Carolina (Y.Z., H.S., D.J.C., A.E.H., D.O.W.); Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts (D.J.C.); Federation of State Medical Boards, Euless, Texas (A.Y.); and Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota (D.O.W.). Pediatric Department, Tong Ren Hospital, Capital Medical University, Beijing - China College of Life Science, Sichuan University, Chengdu 610041, PR China Department of Geriatric, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China Molecular Biology Laboratory, Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, Yunnan Province, China. School of Life Sciences, East China Normal University, Shanghai, PR China Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892 Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, P. R. China Department of Obstetrics, Gynecology, and Reproductive Sciences, Center for Reproductive Sciences, University of California, San Francisco (UCSF), San Francisco, California 94143; Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California, San Francisco (UCSF), San Francisco, California 94143 Department of Radiotherapy, Tianjin General Hospital, Tianjin, China 1State Key Laboratory of Virology, Department of Medical Microbiology, School of Medicine, Wuhan University, Wuhan, China. From the Departments of Epidemiology (A.E.C., L.F.B., P.A.P.) and Biostatistics (Y.Z., X.L.), University of Michigan, Ann Arbor, and Department of Diagnostic Radiology (P.F.S., J.F.B., P.A.A.), Division of Nephrology and Hypertension, Department of Internal Medicine (S.T.T.), and Division of Cardiovascular Diseases (I.J.K.), Mayo Clinic and Foundation, Rochester, Minn. Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China School of Chemistry and Chemical Engineering; Guangxi University for Nationalities; 188 Daxue East Road; Nanning; P. R. China Beijing Anding Hospital; Capital Medical University; Beijing China Department of Thyroid Surgery, Affiliated Hospital of Guizhou Medical University, China Department of Central Laboratory, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China Department of Clinical Laboratory, The Affiliated Children’s Hospital of Nanchang University, Nanchang, Jiangxi, PR China Department of Chemical Engineering, Stanford University, Stanford, California 94305, United States Department of Health Behavior & Health Education, School of Public Health, and State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjing 210023 P. R. China Southern Regional Collaborative Innovation Center for Grain and Oil Crops in China, School of Agriculture Hunan Agricultural University Changsha 410128 China College of Mathematics and Statistics, Institute of Statistical Sciences, Shenzhen University, ShenZhen, China. Department of Cancer Center, The Second Affiliated Hospital, Chongqing Medical University , Chongqing , China The Gastroenterology Tumor and Microenvironment Laboratory, Department of Gastroenterology, The First Affiliated Hospital of Chengdu Medical College, Chengdu Medical College, Chengdu, Sichuan, PR China Center for Reproductive Sciences, Department of Obstetrics, Gynecology, and Reproductive Sciences, University of California San Francisco (UCSF), San Francisco, CA 94143; Department of Medical Cell Biology and Genetics, Guangdong Key Laboratory of Genomic Stability and Disease Prevention, Shenzhen Key Laboratory of Anti-aging and Regenerative Medicine, and Shenzhen Engineering Laboratory of Regenerative Technologies for Orthopaedic Diseases, Health Science Center, Shenzhen University, Shenzhen, China. [email protected]. Lungene Technologies Co., Ltd, Shenzhen, China. [email protected]. The First Affiliated Hospital of Chongqing Medical University, Chongqing Eye Institute, and Chongqing Key Laboratory of Ophthalmology Chongqing China State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro‐products Ningbo University Ningbo China; School of Marine Sciences Ningbo University Ningbo China Key Laboratory of Mountain Ecological Restoration and Bioresource Utilization, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, People’s Republic of China Oncology Department of Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, No. 600 Yishan Road, Xuhui District, Shanghai, 200233, China Department of Toxicology; Anhui Medical University; Hefei China The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong University, 710049, Xi'an, Shaanxi, China; Bioinspired Engineering and Biomechanics Center (BEBC), Xi'an Jiaotong University, 710049, Xi'an, Shaanxi, China Department of Clinical Pharmacy Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China Nan-ning Institute of Transfusion Medicine, Nanning 530007, Guangxi Zhuang Autonomous Region, China. Department of Radiotherapy Oncology, The First Affiliated Hospital of University of Science and Technology of China (West Area), Anhui Provincial Cancer Hospital, Hefei, China. Department of Respiratory Diseases, Affiliated Hangzhou First Peopleʼs Hospital, Zhejiang University School of Medicine, Hangzhou, China Department of General Surgery, The Second Hospital of Jilin University, Changchun, Jilin, China College of Biological Sciences and Biotechnology, National Engineering Laboratory for Tree Breeding, Beijing Forestry University, Beijing, China; Beijing Key Laboratory of Greening Plants Breeding, Beijing Institute of Landscape Architecture, Beijing, China Department of Neurosurgery, Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing Jiangsu Province China Department of Radiology Renji Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai 200127 China Clinical Laboratory Center, The Affiliated Hospital of Guizhou Medical University, Guiyang 550004, China Beijing Institute for Neuroscience Beijing Center of Neural Regeneration and Repairing Key Laboratory for Neurodegenerative Diseases of the Ministry of Education Capital Medical University Beijing China Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, PR China Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Gastrointestinal Cancer Center, Peking University Cancer Hospital and Institute, Beijing, China. Department of Orthopedics, Central Laboratory, Renmin Hospital of Wuhan University, Wuhan, China Department of Obstetrics and Gynecology, University of California San Francisco, San Francisco, California Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, The Key Laboratory of Breast Cancer Prevention and Therapy, Ministry of Education, Key Laboratory of Cancer Prevention and Therapy, Tianjin, PR China School of Science; Tianjin University of Commerce; Tianjin 300134; P. R. China RegCMC, Great Regulatory Affairs, Sanofi (China) Investment Co., Ltd, Beijing, China. School of Environment and Architecture, University of Shanghai for Science and Technology, Shanghai 200093, China State Key Laboratory of Bioreactor Engineering School of Bioengineering East China University of Science and Technology Shanghai P. R. China Optoelectronic System Laboratory, Institute of Semiconductors, CAS, Beijing 100083, China; College of Materials Science and Opto-Electronics Technology, University of Chinese Academy of Sciences, Beijing 100049, China; School of Electronic, Electrical and Communication Engineering, University of Chinese Academy of Sciences, Beijing 100049, China The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California, San Francisco, CA 94143-0665 1Department of Pulmonary Disease, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai, China. Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, SK S7N 5E3, Canada PhD, RD, Respiratory Physician, Geriatric Department of Taikang Chengdu Hospital, and Center of Gerontology and Geriatrics, and National Clinical Research Center of Geriatrics, West China Hospital, Sichuan University, Taiwan, ROC. Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China Key Laboratory of Quality and Safety Control of Citrus Fruits, Ministry of Agriculture and Rural Affairs, Southwest University, Chongqing 400712, P. R. China; National Citrus Engineering Research Center, Citrus Research Institute, Southwest University, Chongqing 400712, P. R. China Laboratory of Bacterial Pathogenesis, Department of Medical Microbiology and Parasitology, Institutes of Medical Sciences, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Shanghai Chest Hospital Affiliated with Shanghai Jiao Tong University, Shanghai, China Merck & Co North Wales PA USA Center for Reproductive Sciences and Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco (UCSF), San Francisco, California 94158 Tianjin Jinhang Institute of Technical Physics School of Materials Science and Engineering, Anhui University, Hefei 230601, P. R. China; Key Laboratory of Functional Molecular Solids, Ministry of Education, College of Chemistry and Materials Science, Anhui Normal University, Wuhu, 241002, China The Third School of Clinical Medicine, Ningxia Medical University, Yinchuan, China; Department of Gastroenterology, Endoscopic center, People’s Hospital of Ningxia Hui Autonomous Region, Yinchuan, China Heilongjiang Provincial Key Laboratory of Laboratory Animal and Comparative Medicine, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China Department of Pathology, Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China. Department of Pharmacy The First Hospital of Lanzhou University Lanzhou 730000 People's Republic of China State Key Laboratory of Tree Genetics and Breeding Northeast Forestry University Harbin China Department of Molecular, Cellular and Developmental Biology College of Chemistry and Pharmaceutical Sciences Qingdao Agricultural University Qingdao P. R. China Department of Traditional Chinese Medicine, Agronomy College of Henan Agricultural University, Zhengzhou 450002, P.R. China Fox Chase Cancer Center, Philadelphia, PA 19111 1 State Key Laboratory of Medicinal Chemical Biology, Key Laboratory of Functional Polymer Materials (Ministry of Education), Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), and College of Chemistry, Nankai University, Tianjin 300071, China Department of Radiology The First Affiliated Hospital of Nanjing Medical University Nanjing China State Key Laboratory of Bioreactor Engineering, School of Bioengineering, East China University of Science and Technology, 130 Mei-Long Road, P.O. Box 309, Shanghai 200237, China Department of Ultrasound Tianjin Third Central Hospital Tianjin Key Laboratory of Artificial Cell Tianjin China Centers for Disease Control and Prevention, Fort Collins, Colorado Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China Department of Pediatrics, Beijing Tongren Hospital Capital Medical University, Beijing, People’s Republic of China Vaccine and Infectious Disease Organization – International Vaccine Center (VIDO-InterVac), University of Saskatchewan, Saskatoon, Saskatchewan, Canada Shenzhen University Medical School Guangdong Key Laboratory of Genomic Stability and Disease Prevention, Shenzhen Key Laboratory of Anti-Aging and Regenerative Medicine, Shenzhen Engineering Laboratory of Regenerative Technologies for Orthopedic Diseases, Department of Medical Cell Biology and Genetics, , Shenzhen 518060, China; Lungene Biotech Ltd , Shenzhen 518110, China National Laboratory of Integrated Management of Insect Pests and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100080, China; andBeijing Genomics Institute, Chinese Academy of Sciences, Beijing 101300, China Department of Intensive Care Unit, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China Department of Radiology, Ren Ji Hospital, School of Medicine; Shanghai Jiao Tong University; Shanghai China Fibrosis Research Center, Center for Immunology and Inflammatory Diseases, Division of Pulmonary and Critical Care Medicine Massachusetts General Hospital, Harvard Medical School Boston Massachusetts USA; Department of Physiology Xiangya Medical School, Central South University Changsha China Department of Orthopaedics, People's Hospital of Luotian County, Luotian 438600, Hubei, China. [email protected] 4Biostatistics Facility, Fox Chase Cancer Center, Philadelphia, Pennsylvania. Department of Medical Oncology The Affiliated 6th People's Hospital of Shanghai Jiaotong University Shanghai 200233 China Clinical Genetics Group, MRC Weatherall Institute of Molecular Medicine; University of Oxford; Oxford UK Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Disease Kunming China Cancer Centre, Faculty of Health Sciences University of Macau, Avenida de Universidade China Department of Mechanical Engineering, Texas A&M University, College Station, TX 77843-3123, USA Department of Radiology, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 20012, China The Gastroenterology Tumor and Microenvironment Laboratory, Department of Gastroenterology, The First Affiliated Hospital of Chengdu Medical College, Chengdu Medical College, Chengdu 610041, Sichuan, PR China Heilongjiang Provincial Key Laboratory of Laboratory Animal and Comparative Medicine, Laboratory Animal and Comparative Medicine, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150069, China Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratories of Bioorganic Chemistry and Molecular Engineering and of Polymer Chemistry and Physics of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, and Institute of Polymer Optoelectronic Materials and Devices, South China University of Technology, and Key Laboratory of Specially Functional Materials of Ministry of Education, Guangzhou 510640, China School of Chemistry Beijing Advanced Innovation Center for Biomedical Engineering Beihang University Beijing 100191 China Department of Chemistry, Wuhan University, Wuhan 430072, China [email protected] From the Cardiovascular Research Center, Temple University School of Medicine, Philadelphia, PA (S.M., C.D.T., T.S., T.E.S., E.J.A., S.S., J.M.D., N.Z., H.K., R.M.B., S.R.H.); and Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, Philadelphia, PA (Y.Z.). Advanced Environmental Biotechnology Centre, Nanyang Environment & Water Research Institute, Nanyang Technological University, Singapore; School of Civil & Environmental Engineering, Nanyang Technological University, Singapore Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan, China Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, Canada Orthopaedic Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei, China From the Departments of Molecular Pathology, Experimental Therapeutics, and Leukemia, The University of Texas M. D. Anderson Cancer Center, Houston, TX. Zigong Hospital of TCM, Zigong, China Department of Ultrasound Tianjin Third Central Hospital Tianjin 300170 China; Tianjin Institute of Hepatobiliary Disease, Tianjin Key Laboratory of Artificial Cell, Artificial Cell Engineering Technology Research Center of Public Health Ministry Tianjin Third Central Hospital Tianjin 300170 China Blood Purification Center, The Second People’s Hospital Lishui, Lishui 323000, China International Joint Research Laboratory of New Energy Materials and Devices of Henan Province, School of Physics and Electronics, Henan University, Kaifeng 475004, P.R. China Department of Obstetrics, Gynecology and Reproductive Sciences, Center for Reproductive Sciences, University of California San Francisco, San Francisco, CA;; The Eli & Edythe Broad Center for Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA; Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, P.R. China Institute of Advanced Manufacturing and Modern Equipment Technology, School of Mechanical Engineering, Jiangsu University, Zhenjiang 212013, China College of Acupuncture-Moxibustion and Tuina, Shandong University of TCM, Jinan 250014, China. Oncology Department, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, P.R. China Department of Stomatology, Xinqiao Hospital, Third Military Medical University Chongqing, China. The First Affiliated Hospital of Wenzhou Medical University, Rheumatology, Wenzhou, China. School of Life Science and Biotechnology, Shenyang Pharmaceutical University, Shenyang 110016, China. [email protected] School of Materials Science and Engineering China University of Petroleum (East China) Qingdao Shandong 266580 China Department of Urology Hebei Provincial Hospital of Traditional Chinese Medicine Shijiazhuang China Advanced Environmental Biotechnology Centre Nanyang Environment and Water Research Institute Nanyang Technological University 1 CleanTech Loop Singapore 637141 Department of Radiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China Center for Alloy Innovation and Design (CAID) State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University Xi'an Shaanxi 710049 P. R. China Department of Cardiology, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, China; Beijing University of Chinese Medicine, Beijing, China Department of Radiology, First Affiliated Hospital, Zhengzhou University, Zhengzhou 450052, China. State Key Laboratory of Heavy Oil Processing Centre for Bioengineering and Biotechnology, and College of Science China University of Petroleum (East China) Qingdao 266580 China Division of Maternal–Fetal Medicine, Department of Obstetrics, Gynecology and Reproductive Sciences University of California San Francisco CA USA; Center for Reproductive Sciences, Department of Obstetrics, Gynecology and Reproductive Sciences University of California San Francisco CA USA; The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research University of California San Francisco CA USA Department of Pharmacy the First Hospital of Lanzhou University Lanzhou 730000 China The First Affiliated Hospital of Chongqing Medical University, Chongqing Eye Institute, Chongqing and Chongqing Key Laboratory of Ophthalmology; Chongqing; P.R. China Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan, Canada S7N 5E3 Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY, USA. Department of Laboratory Medicine,Zhongshan Hospital, Fudan University, Shanghai 200032, China. Department of Radiology Renji Hospital, School of Medicine, Shanghai Jiao Tong University Shanghai China First Medical College of Zhejiang Chinese Medical University, Hangzhou 310000, China Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5E3, Canada Ningxia Medical University Yinchuan, China. State Key Laboratory of Integrated Optoelectronics, College of Electronic Science and Engineering, Jilin University, Changchun 130012, China College of Coastal Agricultural Sciences, Guangdong Ocean University, Zhanjiang 524088, China Medical Laboratory Department, The Second Hospital of Hebei Medical University Hubei Provincial Key Laboratory of Applied Toxicology, National Reference Laboratory of Dioxin, Hubei Provincial Center for Disease Control and Prevention, Wuhan 430079, China Vaccine and Infectious Disease Organization, University of Saskatchewan Saskatoon Saskatchewan Canada Laboratory of the Biology of Addictive Diseases the Rockefeller University New York New York 10065 The American Board of Anesthesiology, Raleigh, North Carolina National Clinical Research Center of Kidney Diseases, Jingling Hospital, Nanjing University School of Medicine Nanjing 210016, China. Department and Institute of Psychology, Ningbo University, Ningbo, China Faculty of Materials Science and Engineering, Kunming University of Science and Technology, Kunming, 650093, People's Republic of China Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, PR China State Key Laboratory of Catalysis Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China Faculty of Life Science and Technology Kunming University of Science and Technology Kunming 650500, Yunnan P. R. China Zhejiang University Hangzhou China; Westlake Laboratory of Life Sciences and Biomedicine Key Laboratory of Structural Biology of Zhejiang Province School of Life Sciences Westlake University Hangzhou China; Institute of Basic Medical Sciences Westlake Institute for Advanced Study Hangzhou Zhejiang China Life Sciences Institute and Innovation Center for Cell Biology; Zhejiang University; Hangzhou Zhejiang 310058 China Department of Obstetrics and Gynaecology Wuhan Medical Care Center for Women and Children Wuhan China; Fetal Medicine Unit, Department of Obstetrics and Gynaecology The Chinese University of Hong Kong, Prince of Wales Hospital Hong Kong China Department of Cardiology, Shaoxing People’s Hospital (Shaoxing Hospital, Zhejiang University School of Medicine), Shaoxing 312000, Zhejiang, China Department of Obstetrics, The First Affiliated Hospital with Nanjing Medical University, Nanjing, China Liaoning Key Laboratory of Clean Energy and College of Energy and Environmental Shenyang Aerospace University Shenyang China Center of Gastrointestinal Disease, The Affiliated Changzhou NO.2 People’s Hospital of Nanjing Medical University, Changzhou, China Department of Obstetrics and Gynecology, Wuhan Children’s Hospital, Tongji Medical College, Huazhong University of Science & Technology, Wuhan 430016, China Key Laboratory of Forage and Endemic Crop Biology, Ministry of Education, College of Life Sciences Inner Mongolia University Hohhot China College of Chemistry and Chemical Engineering, Henan Key Laboratory of Function-Oriented Porous Materials, Luoyang Normal University, Luoyang 471934, P. R. China Department of Surgery Yixing People's Hospital Yixing China Laboratory of the Biology of Addictive Diseases, The Rockefeller University, New York, NY 10065 Center for High Pressure Science & Technology Advanced Research, Shanghai 201203, China Department of Pharmaceutics, University of Minnesota, Minneapolis, MN 55455, USA. 1Department of Laboratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, P.R. China. Department of Chemistry; University of Cincinnati; Cincinnati; USA Department of Scientific research and teaching, Tai Zhou People's HospitaL, Jiangsu Taizhou225300, China. Department of Anesthesiology and Critical Care Medicine Materials Science and Technology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee 37830, United States Institute of Pharmaceutics Hangzhou Institute of Innovative Medicine College of Pharmaceutical Sciences Zhejiang University Hangzhou 310058 China School of Politics and Public Administration, Southwest University of Political Science and Law, No. 301 Baosheng Road, Chongqing 401120, China Platelet Immunohematology Laboratory of Nanning Institute of Transfusion Medicine, Nanning, Guangxi 530007, China; Platelet Immunohematology Laboratory of Nanning Blood Center, Nanning, Guangxi 530007, China. Department of Neurology, Xishan People’s Hospital, Xishan District, Wuxi, Jiangsu Province Department of Obstetrics, Gynecology and Reproductive Sciences, Center for Reproductive Sciences, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, United States Department of General Surgery Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University Nanjing China Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-Sen University , Guangzhou, China; Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-Sen University , Guangzhou, China Southwestern Institute of Physics , Chengdu, Sichuan 610041, People’s Republic of China Department of Critical Care Medicine The Third Affiliated Hospital of Guangzhou Medical University Guangzhou Guangdong China; Guangdong Provincial Key Laboratory of Major Obstetric Diseases Guangzhou China; Guangdong Provincial Clinical Research Center for Obstetrics and Gynecology Guangzhou China School of Civil and Environmental Engineering, Nanyang Technological University, Singapore;; Advanced Environmental Biotechnology Centre, Nanyang Environment and Water Research Institute, Nanyang Technological University, Singapore School of Energy and Power Engineering Shandong University Jinan Shandong 250061 China; Optics & Thermal Radiation Research Center Institute of Frontier and Interdisciplinary Science Shandong University Qingdao Shandong 266237 China College of Chemistry and Chemical Engineering and Henan Key Laboratory of Function-Oriented Porous Materials, Luoyang Normal University, Luoyang, 471934, P. R. China Vaccine Research Center, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland Department of Chemistry & Biochemistry; Florida State University; Tallahassee; USA Department of Radiology, Renji hospital, School of Medicine Shanghai Jiao Tong University Shanghai China Department of Clinic, Medicine School, Changsha Social Work College, Changsha, Hunan, China College of Life Sciences Hunan Normal University Changsha 410081 China Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Shatin, N.T., Hong Kong, People’s Republic of China, and Bioengineering Graduate Program, Department of Chemical and Biomolecular Engineering, and Department of Biology, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, People’s Republic of China Program in Developmental Therapeutics, Fox Chase Cancer Center, Philadelphia, Pennsylvania 19111 Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205; Department of Chemistry & Biochemistry, Florida State University, Tallahassee, Florida 32306, United States Department of Oncology, the Affiliated Yixing Hospital of Jiangsu University, Wuxi, Jiangsu 214200, China Johns Hopkins University School of Medicine Anesthesiology and Critical Care Medicine School of Biological Sciences, Nanyang Technological University Department of Infectious Diseases, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang 830054, China State Key Laboratory of Bioreactor Engineering East China University of Science and Technology Shanghai 200237 P. R. China Department of Biochemistry and Molecular Biology, School of Medicine, Nantong University, Nantong, Jiangsu Province, China The Key Laboratory of Biomedical Information Engineering of Ministry of Education School of Life Science and Technology Xi'an Jiaotong University 710049 Xi'an P. R. China; Bioinspired Engineering and Biomechanics Center (BEBC) Xi'an Jiaotong University 710049 Xi'an P. R. China Department of Neurology, David Geffen School of Medicine, University of California, Los Angeles2Mary S. Easton Center for Alzheimer’s Disease Research, University of California, Los Angeles Nanning Blood Center Nanning Institute of Transfusion Medicine Nanning Guangxi China Department of Nephrology, Affiliated Hospital of Qingdao University, Qingdao, Shandong, China Department of Nursing, Medical College, Hebei University of Engineering, Handan 056002, Korea. State Key Laboratory of Precision Spectroscopy East China Normal University Dongchuan Road 500 Shanghai 200241 China Hangzhou Genomics Institute–Institute of Bioinformatics of Zhejiang University–Key Laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, China.; Fudan University, Shanghai 200433, China. Southwestern Institute of Physics 2 , P.O. Box 432, No. 3 South Section 3, Circle Road 2, Chengdu 610041, Sichuan, China Laboratory of Gene Therapy, Department of Aging Intervention National Center for Geriatrics and Gerontology Obu Aichi, 474‐8522 College of Pharmacy, Xinjiang Medical University Urumqi 830011, China. Department of Chemistry The Hong Kong University of Science and Technology Clear Water Bay, Kowloon Hong Kong SAR China Xin'anjiang Forest Center, Jiande 311600, Zhejiang, China. Department of General Surgery Changzhou No. 2 People's Hospital affiliated with Nanjing Medical University Changzhou China Beijing Key Laboratory of Materials Utilization of Nonmetallic Minerals and Solid Wastes National Laboratory of Mineral Materials School of Materials Sciences and Technology China University of Geosciences Beijing 100083 China School of Chemistry, Beijing Advanced Innovation Center for Biomedical Engineering, Beihang University, Beijing 100191, China Shanghai Center for Systems Biomedicine, Shanghai 200240, China. Division of Basic Science, Fox Chase Cancer Center, Philadelphia, PA 19111 Department of Radiology, Renji Hospital Shanghai JiaoTong University School of Medicine Shanghai China State Key Laboratory of Supramolecular Structure and Materials, College of Chemistry, Jilin University, Changchun 130012, P. R. China Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, People's Republic of China School of Science and Engineering, The Chinese University of Hong Kong, Shenzhen 518172, China The State Key Laboratory of Bioreactor Engineering, East China University of Science and Technology, Shanghai - China School of Materials Science and Engineering China University of Petroleum (East China) 66 West Changjiang Road Qingdao Shandong 266580 P. R. China Division of Rheumatology, Allergy and Immunology, Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. Fibrosis Research Center, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA. The National Center for Drug Screening and the CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica Chinese Academy of Sciences (CAS) Shanghai P. R. China Department of Ultrasound, The Affiliated Hospital of Yunnan University (The Forth Affiliated Hospital of Kunming Medical University, The Second People’s Hospital of Yunnan Province), Kunming, Yunnan, China York-Nanjing Joint Center for Spintronics and Nanoengineering, School of Electronics Science and Engineering, Nanjing University, Nanjing 210093, China; Department of Physics, The University of Hong Kong, Pokfulam, Hong Kong Nanjing Institute of Environmental Science, Ministry of Ecology and Environment, Nanjing 210042, China. State Environmental Protection Key Laboratory of Soil Environmental Management and Pollution Control, Nanjing 210042, China. Department of Urology, Shanghai Yangsi Hospital, Shanghai, China (mainland) Mary S. Easton Center for Alzheimer's Disease Research, Department of Neurology, David Geffen School of Medicine at UCLA, Los Angeles, CA, USA Department of Medical Cell Biology and Genetics, Guangdong Key Laboratory of Genomic Stability and Disease Prevention, Shenzhen Key Laboratory of Anti-aging and Regenerative Medicine, and Shenzhen Engineering Laboratory of Regenerative Technologies for Orthopaedic Diseases, Health Sciences Center, Shenzhen University, Shenzhen, China. [email protected]. Lungene Technologies Co., Ltd., Shenzhen, China. [email protected]. Fox Chase Cancer Center, Philadelphia, PA 19111, USA. Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, China The Third School of Clinical Medicine, Ningxia Medical University, Yinchuan, China. Department of Radiology, Institute of Molecular Medicine, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai 200240, China The Center for Vaccines and Immunity, Nationwide Children's Hospital, Columbus, Ohio Department of Neurosurgery, PLA Air Force Medical Center, Beijing 100142, China The National Center for Drug Screening, The CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 201203 Shanghai, China Advanced Environmental Biotechnology Center, Nanyang Environment and Water Research Institute, Nanyang Technological University, 1 Cleantech Loop, Singapore 637141, Singapore; School of Civil and Environmental Engineering, Nanyang Technological University, 50 Nanyang Avenue, Singapore 639798, Singapore Department of Cancer Center, Second Affiliated Hospital Chongqing Medical University Chongqing China Department of Agronomy, Iowa State University, Ames, Iowa 50011, USA Optoelectronic System Laboratory, Institute of Semiconductors, CAS, Beijing 100083, China Department of Neurosurgery, Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School Nanjing People's Republic of China Department of Pediatrics, Second West China Hospital of Sichuan University, Chengdu 610041, China. Department of Preventive Dentistry, Hospital of Stomatology, Sun Yat-sen University, Guangzhou, PR China; Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou, PR China Joint Laboratory of Modern Agricultural Technology International Cooperation Ministry of Education Jilin Agricultural University Changchun China; Key Laboratory of Animal Production Product Quality and Security Ministry of Education Jilin Agricultural University Changchun China State Key Laboratory of Developmental Biology of Freshwater Fish, Hunan Normal University, Changsha 410081, Hunan, People’s Republic of China State Key Laboratory of Medicinal Chemical Biology Key Laboratory of Functional Polymer Materials (Ministry of Education) Tianjin Key Laboratory of Functional Polymer Materials College of Chemistry Nankai University Tianjin 300071 China Beijing Hospital, National Center of Gerontology, Beijing 100730, China Department of Immunology, Hebei North University, Zhangjiakou 075000, China. State Key Laboratory of Coordination Chemistry, Key Laboratory of Mesoscopic Chemistry of MOE, School of Chemistry and Chemical Engineering, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 210023, P. R. China Department of Endocrinology of Beijing Hospital of the Ministry of Health, Beijing 100730, China. Department of ICU, West China Hospital of Sichuan University Chengdu, Sichuan, China. Clinical Trials Center The Affiliated Hospital of Guizhou Medical University Guiyang China Department of Nursing, Medical College, Hebei University of Engineering, Handan 056002, P.R. China Zhangjiagang Center for Disease Prevention and Control, Zhangjiagang 1Fox Chase Cancer Center, Philadelphia, Pennsylvania. Chinese Medicine Laboratory, Hong Kong Jockey Club Institute of Chinese Medicine, Shatin, N. T., Hong Kong, People’s Republic of China, Division of Bioengineering, School of Chemical and Biomedical Engineering, Nanyang Technological University, 70 Nanyang Drive, Singapore 637457, Institute of Medicinal Plant Development, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100083, People’s Republic of China, and School of Chemistry and Biotechnology, Yunnan Nationalities... Department of Gastrointestinal Surgery, The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University, Changzhou, Jiangsu 213000, P.R. China Department of Physiology, Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, P.R. China Canadian Institute for Advanced Research, Centre Robert Cedergren, Département de Biochimie, Université de Montréal, Succursale Centre-Ville Montréal, Québec H3C3J7, Canada; E-mail: [email protected] (H.P.) College of Chemistry and Materials Science, The Key Laboratory of Electrochemical Clean Energy of Anhui Higher Education Institutes, Anhui Provincial Engineering Laboratory for New-Energy Vehicle Battery Energy-Storage Materials, Anhui Normal University, Wuhu, 241002, China Shanghai Institute of Immunology, Department of Immunology and Microbiology, Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai Jiao Tong University School of Medicine, Shanghai, China 1 Faculty of Health Sciences University of Macau Taipa Macau Breast Disease Center, the First Affiliated Hospital of The Third Military Medical University, Chongqing, 400038, China Department of Pulmonary Disease, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai 200030, China. Department of Pharmacology, Guangxi Medical University, Nanning 530021, China. [email protected] Hubei Provincial Key Laboratory of Applied Toxicology, National Reference Laboratory of Dioxin, Hubei Provincial Center for Disease Control and Prevention, Wuhan, Hubei 430079, China Oncology Department of Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China Department of Medical Oncology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, China Department of Oncology, The Affiliated Yixing Hospital of Jiangsu University, Wuxi 214200, Jiangsu, People's Republic of China College of Chemical Engineering, State Key Laboratory of Heavy Oil Processing and ‡College of Science, China University of Petroleum, Qingdao 266580, P. R. China 4Biostatistics and Bioinformatics Facility, Fox Chase Cancer Center, Philadelphia, Pennsylvania. State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200032 P. R. China; Central Laboratory Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 P. R. China The National Engineering Research center for Bioengineering Drugs and the Technologies; Institute of Translational Medicine; Nanchang University; Nanchang; P.R. China Department of Ophthalmology, Liaocheng People's Hospital, Liaocheng, Shandong 252000, P.R. China Department of Oncology, People's Hospital of Yixing City, Yixing, Jiangsu 214200, P. R. China. State Key Laboratory of Natural Medicines, School of Life Science and Technology, China Pharmaceutical University, Nanjing, Jiangsu 210009, China Nanjing Medical University, China Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macau SAR, PR China Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Structural Chemistry of Unstable and Stable Species, and Department of Chemical Biology, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China College of Life Sciences, Beijing Normal University, Beijing 100875, China; and; National Institute of Biological Sciences, Beijing 102206, China Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430022, P.R. China Department of Orthopedics, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China Department of Pediatric Surgery, Capital Institute of Pediatrics, No. 2 Yabao Road, Chaoyang District, Beijing, People's Republic of China; Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, People's Republic of China Beijing National Laboratory for Molecular Sciences, the Key Laboratory of Bioorganic Chemistry and Molecular Engineering of the Ministry of Education, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China Key Laboratory of Flexible Electronics (KLOFE) & Institute of Advanced Materials (IAM) School of Flexible Electronics (Future Technologies) Nanjing Tech University Nanjing 211816 China Department of Radiology, Ren Ji Hospital, School of Medicine; Shanghai Jiaotong University; Shanghai China Wuhan Academy of Agricultural Sciences , Wuhan, 430072 , China State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Sun Yat-sen University Cancer Center, Guangzhou 510060, China School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China. [email protected] State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, People’s Republic of China State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, P. R. China, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, P. R. China, and Shanghai Institute of Materia Medica, Shanghai Institute for Biological Science, Chinese Academy of Sciences, Shanghai 200032, P. R. China Physical Medicine and Rehabilitation Center, The Second Affiliated Hospital and Yuying Children's Hospital of Wenzhou Medical University, Wenzhou, Zhejiang 325027, P.R. China Latvia MGI Tech, LV-2167 Mārupe, Latvia Guangzhou Institute of Pediatrics, Department of Neonatology, Guangzhou Women and Children’s Medical Center, Guangzhou Medical University, 510623 Guangzhou, China Biophysics Center for Integrative Physiology and Molecular Medicine, School of Medicine, Saarland University Homburg 66421 Germany Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China; Institute of Neurological Diseases, Xuzhou Medical University, Xuzhou, China Department of Nephrology, Shandong Provincial Hospital affiliated to Shandong First Medical University , Jinan, Shandong , China Department of Nursing, Medical College, Hebei University of Engineering, Handan 056002, China School of Energy & Power Engineering, Xi’an Jiaotong University, Xi’an 710049, China The Rockefeller University, New York, USA State Key Laboratory of Catalysis Dalian Institute of Chemical Physics, Chinese Academy of Sciences Dalian 116023 China Unit 703, 7th floor, Bioinformatics Centre, Hong Kong Jockey Club Institute of Chinese Medicine, 2 Science Park West Avenue, Shatin, New Territories, Hong Kong, China From the Department of Neurology (L.X., W.S., Q.D., Y.X., W.F., N.M., Z.G., X.C., X.X., L.X., W.Z., G.X., X.L.), Department of Radiology (L.L.), and National Clinical Research Center of Kidney Diseases (Y.Z.), Jinling Hospital, Medical School of Nanjing University, Nanjing, China; Department of Geriatric Neurology, Nanjing Brain Hospital Affiliated to Nanjing Medical University, Nanjing, China (W.L.); and Department of Medicine, Royal Melbourne Hospital, University of Melbourne (P.Z.). Westlake Laboratory of Life Sciences and Biomedicine, Key Laboratory of Structural Biology of Zhejiang Province, School of Life Sciences, Westlake University, No.18 Shilongshan Road, Hangzhou 310024, China; Institute of Basic Medical Sciences, Westlake Institute for Advanced Study, No.18 Shilongshan Road, Hangzhou 310024, China; Research Center for Industries of the Future, Westlake University, No.600 Dunyu Road, Hangzhou 310030, China State Key Laboratory of Oncogenes and Related Genes Shanghai Cancer Institute Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200032 China; Central Laboratory Ren Ji Hospital School of Medicine Shanghai Jiao Tong University Shanghai 200127 China School of Materials Science and Engineering China University of Petroleum (East China) Qingdao 266580 China School of Life Science and Technology, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing 210009, China Institute for Special Environmental Biophysics, Key Laboratory for Space Bioscience and Biotechnology, School of Life Sciences, Northwestern Polytechnical University, 710072 Xi’an, China. Department of Rheumatology and Immunology The First Affiliated Hospital of Wenzhou Medical University Wenzhou China Department of Oncology, Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai, China Materials Science and Mechanical Engineering, Texas A&M University, College Station, TX, USA. Biostatistics and Bioinformatics Program Fox Chase Cancer Center Philadelphia Pennsylvania Frontier Science Center for Immunology and Metabolism Medical Research Institute at School of Medicine Wuhan University Wuhan China Department of Thoracic Surgery Ningxia Hui Autonomous Region People's Hospital Yinchuan City Ningxia Hui Autonomous Region P.R. China Department of Chemistry, Nantional University of Singapore, 3 Science Drive 3, Singpaore 117543 Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China; Key Laboratory of Obstetric & Gynecologic and Pediatric Diseases and Birth Defects of Ministry of Education, Sichuan University, Chengdu, China Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University , Shanghai , China Department of Biomedicine, Aarhus University, Aarhus, Denmark State Key Laboratory of Reproductive Medicine Nanjing Medical University Nanjing China; Department of Epidemiology School of Public Health Center for Global Health Nanjing Medical University Nanjing China; Jiangsu Key Lab of Cancer Biomarkers Prevention and Treatment Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical University Nanjing China Department of Emergency Medicine, Affiliated Kunshan Hospital of Jiangsu University, Kunshan, Jiangsu 215300, P.R. China Department of Neurology Jianyang People's Hospital Jianyang China Department of Neurosurgery, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School, Nanjing, China. The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, and Chongqing Eye Institute, Chongqing, P. R. China; and the Wenzhou Key Laboratory of Sanitary Microbiology, School of Laboratory Medicine and Life Sciences, Wenzhou Medical University, Wenzhou, Zhejiang, China Wuhan Academy of Agricultural Sciences , Wuhan 430072 , China Henan Province Engineering Research Center of Smart Micro-nano Sensing Technology and Application, School of Physics and Electronics, Henan University, Kaifeng 475004, P. R. China From the American Board of Anesthesiology, Raleigh, North Carolina (H.S., Y.Z., D.J.C., C.A.L., A.E.H., D.O.W.); Department of Anesthesiology, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts (D.J.C.); Department of Anesthesiology, Weill Cornell Medical College, New York, New York (C.A.L.); and Department of Anesthesiology, Mayo Clinic, Rochester, Minnesota (D.O.W.). Department of Radiology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, P.R. China Co-Innovation Center for Sustainable Forestry in Southern China, College of Biology and the Environment, Nanjing Forestry University, Nanjing, China The Aoyang Cancer Institute, The Affiliated Aoyang Hospital of Jiangsu University, Zhangjiagang, 215617 Jiangsu, China |
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