http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_8d62e92969b4c33faf17a23a454dcb85
Outgoing Links
Predicate | Object |
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family-name | Yang Tao Yang |
name | Tao Yang |
given-name | Tao |
organization-name | Clinical Medical College of Yangtze University, Neurology Department of the First Affiliated Hospital of Yangtze University, Jingzhou, Hubei, PR China Exploration and Development Research Institute of PetroChina Xinjiang Oilfield Company, Karamay, Xinjiang 834000, China *State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China; Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials; Nanjing University of Posts & Telecommunications; Nanjing 210023; China Neurosurgery Department The First Affiliated Hospital of Jinan University Guangzhou China School of Life Sciences, Tsinghua University, Beijing 100084, China;; Technology Center for Protein Sciences, Tsinghua University, Beijing 100084, China Department of Biliary and Pancreatic Surgery/Cancer Research Center,Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology,Wuhan,Hubei,China Laboratory of Anti-inflammation and Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China; University of Chinese Academy of Sciences, No. 19A Yuquan Road, Beijing 100049, China Province Key Laboratory for Fine Petrochemical Catalysis and Separation, College of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, Hunan, 414000, P. R. China Department of Medicine, Vanderbilt University Medical Center, Nashville, TN; Department of Pharmacology, Vanderbilt University Medical Center, Nashville, TN Key Laboratory of Green Chemistry Materials in University of Yunnan Province, Key Laboratory of Advanced Synthetic Chemistry (Yunnan Minzu University) of National Ethnic Affairs Commission, School of Chemistry and Environment, Yunnan Minzu University, Kunming 650500, P. R. China Department of Materials Science and Engineering, Hong Kong Institute for Advanced Study, College of Science and Engineering, City University of Hong Kong, Hong Kong, China. From the Divisions of Clinical Pharmacology (D.D., T.Y., D.M.R.) and Cardiovascular Medicine (D.D., K.C., D.M.R.), Vanderbilt University School of Medicine, Nashville, Tenn, and Cardiology Department (A.A.M.W.), Academic Medical Center, Amsterdam, the Netherlands. College of Chemistry, Jilin University, Changchun 130021, Jilin, China Key Laboratory of Semiconductor Materials Science, Beijing Key Laboratory of Low Dimensional Semiconductor Materials and Devices, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, People’s Republic of China; College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China Zhuanglang People's Hospital, Pingliang, Gansu 744600, China Department of Traditional Chinese Medicine, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, China Fujian University Key Laboratory for Plant-Microbe interaction, Fujian Agriculture and Forestry University, Fuzhou, China From the Vanderbilt University School of Medicine, Nashville, TN. Biomedical Informatics Research Lab, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing Laboratory of Molecular Nutrition, College of Food Science and Engineering, The Key Laboratory of Hunan Province for Special Medical Food, National Engineering Laboratory for Deep Processing of Rice and Byproducts, Central South University of Forestry and Technology, Changsha, Hunan 410004, China State Key Laboratory of Photocatalysis on Energy and Environment College of Chemistry Fuzhou University Fuzhou, Fujian 350108 China Divisions of Cardiovascular Medicine and Clinical Pharmacology, Vanderbilt University, Nashville, TN, USA State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops College of Plant Protection, Fujian Agriculture and Forestry University Fuzhou China School of Chemical Engineering, Huaihai Institute of Technology, Lianyungang 222005, People’s Republic of China Beijing Advanced Innovation Center for Materials Genome Engineering, Beijing Information Science and Technology University, Beijing 100101, P. R. China Xi’an University of Technology Department of Chemistry; University of Hawai'i at Manoa; Honolulu, USA School of Chemical Engineering The University of New South Wales (UNSW Sydney) Sydney NSW 2052 Australia; School of Chemical and Biomolecular Engineering The University of Sydney Sydney NSW 2006 Australia Departments of Neurosurgery and Department of Nephrology, Affliated Dongfeng Hospital, Hubei University of Medicine, Shiyan, 442008, Hubei, P.R.China Microbiome Consortium and Center for Hypertension and Precision Medicine Department of Physiology and Pharmacology University of Toledo College of Medicine and Life Sciences Toledo OH USA State Key Laboratory for Mineral Deposits Research, Department of Earth Sciences, Nanjing University, Nanjing 210093, People's Republic of China Beijing Advanced Innovation Center for Materials Genome Engineering; Institute of Solid State Chemistry; Department of Physical Chemistry; University of Science and Technology Beijing; Beijing 100083 Department of Endocrinology and Metabolism, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, China MOE Key Laboratory for Non-Equilibrium Synthesis and Modulation of Condensed Matter School of Physics Xi'an Jiaotong University Xi'an 710049 Shaanxi China College of Materials Science and Engineering, Zhejiang University, Hangzhou, 310027 Zhejiang, P. R. China Oil Crops Research Institute, Chinese Academy of Agricultural Sciences, Hubei Key Laboratory of Lipid Chemistry and Nutrition, Key Laboratory of Oilseeds Processing, Ministry of Agriculture, Wuhan 430062, China Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu, Sichuan - P.R. China The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital Nanjing 210000, China. Laboratory of Natural and Targeted Small Molecule Drugs, State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China Department of Neurology, University of Michigan Medical School (UMMS) , Ann Arbor, Michigan , USA Key Laboratory of Animal Genetics, Breeding and Reproduction in the Plateau Mountainous Region; Cell and Molecular Biology (PhD), Animal Department; Guizhou University; Guiyang 550025; China Science and Technology on Advanced Composites Laboratory, AVIC Composite Technology Center, AVIC Manufacturing Technology Institute, Beijing 101300, China Department of Pain Treatment, Tangdu Hospital, Fourth Military Medical University, Xi'an 710038, China Department of Nursing Renmin Hospital of Wuhan University Wuhan China Microbiome Consortium and Center for Hypertension and Precision Medicine, Department of Physiology and Pharmacology, College of Medicine and Life Sciences, University of Toledo, Toledo, OH USA Department of Cardiovascular Surgery, Fuwai Hospital and National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College , Beilishi Road No. 167, Xicheng District, Beijing 100037, China Key Laboratory of Advanced Technologies of Materials (Ministry of Education), School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, PR China College of Food Science and Technology Central South University of Forestry and Technology Changsha Hunan Province China Department of Reproductive Endocrinology, The Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, 712000, China Department of Neurology and Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305, USA Thoracic Surgery, First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China College of Chemical Engineering Nanjing Forestry University Longpan Road 159# Nanjing P.R: China From the Microbiome Consortium, Center for Hypertension and Precision Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH; and Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH (S.J., J.M., X.C., S.G., A.H., P.S., B.S.Y., B.M., J.-Y.Y., M.V-K., T.Y., B.J.). State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Nanjing University Nanjing 210023 P. R. China; Chemistry and Biomedicine Innovation Center Nanjing University Nanjing 210023 P. R. China State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy; West China Hospital; West China Medical School; Sichuan University; Chengdu State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of General Surgery, The Second Hospital of Jilin University, Changchun Jilin, China Department of General Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121001, People’s Republic of China. Department of Pharmacy, Gansu Provincial Maternity and Child Care Hospital, Lanzhou 730050, China. Department of Physiology, Xiangya School of Medicine, Central South University, Changsha 410078, Hunan, China Shandong Provincial Key Laboratory of Animal Resistance Biology, College of Life Sciences, Shandong Normal University, Jinan 250014, China Center for Mitochondrial Biology and Medicine, The Key Laboratory of Biomedical Information Engineering of Ministry of Education, School of Life Science and Technology, Xi'an Jiaotong, University, Xi'an, China Key Laboratory of Eco-Chemical Engineering (Ministry of Education), College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China Department of Surgery, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, P.R. China Department of Neurology University of Michigan Ann Arbor MI Department of Materials Science and Engineering, City University of Hong Kong , Hong Kong , China Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou 730000, China Institute for Chemical Physics & Department of Chemistry, State Key Laboratory of Electrical Insulation and Power Equipment, Xi’an Jiaotong University, Xi’an 710049, China China National GeneBank, Shenzhen 518120, China Guangdong Provincial Key Laboratory of Optical Information Materials and Technology & Institute of Electronic Paper Displays; South China Academy of Advanced Optoelectronics; South China Normal University; Guangzhou 510006; China From the Departments of Pharmacology (T.Y., D.J.S., D.M.R.) and Medicine (D.J.S., D.M.R.), Vanderbilt University School of Medicine, Nashville, Tenn. From the Center for Hypertension and Precision Medicine and Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Ohio. Department of Neurosurgery, Chengdu Military General Hospital Chengdu 610083, China ; Department of Neurosurgery, Third Military Medical University Chongqing 400037, China. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, P.R. China From the Department of Physiology and Pharmacology, Microbiome Consortium, Center for Hypertension and Precision Medicine, University of Toledo College of Medicine and Life Sciences, Toledo, OH (T.Y., S.C., P.S., B.M., X.C., J.-Y.Y., X.M., G.Z., J.M., R.G., B.S.Y., C.G.M., C.W., M.V.-K., B.J.) School of Pharmacy Health Science Center Xi'an Jiaotong University Xi'an 710061 P. R. China From the Departments of Medicine (T.Y., T.C.A., D.M.S., W.Z., L.H., D.R.) and Pharmacology (T.Y., D.R.), Vanderbilt University School of Medicine, Nashville, TN. Department of Endocrinology, The First Affiliated Hospital with Nanjing Medical University (Jiangsu Province Hospital), Nanjing 210029, China Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China; Department of Cardiology, Institute of Cardiovascular Disease of Integrated Traditional Chinese Medicine and Western Medicine, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China; Shanghai Key Laboratory of Traditional Chinese Clinical Medicine, Shanghai, China Department of Neurosurgery, The General Hospital of Western Theater Command, Chengdu, Sichuan 610000, China University of Science and Technology of China 1 Hefei National Laboratory for Physical Sciences at the Microscale and Department of Modern Physics, , Hefei, Anhui 230026, China The Key Laboratory of Veterinary Public Health, Ministry of Agriculture, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, PR China Center of Pulmonary Vascular Disease, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100007, China School of Civil Engineering, Wuhan University, Wuhan 430072, China Department of Otolaryngology-Head and Neck Surgery; Xinhua Hospital, Shanghai Jiaotong University School of Medicine; Shanghai China; Ear Institute; Shanghai Jiaotong University School of Medicine; Shanghai China Key Laboratory of Cell Activities and Stress Adaptations Ministry of Education School of Life Sciences Lanzhou University Lanzhou 73000 China Department of Biochemistry & Molecular Biology Shanxi Medical University Taiyuan China School of Mechanical Engineering; Beijing Institute of Technology; Beijing 100081; China State Key Laboratory of Mineral Deposits Research, Nanjing University Nanjing 210023, China. Key Laboratory of Environmental and Applied Microbiology, Environmental Microbiology Key Laboratory of Sichuan Province, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, China College of Chemistry and Chemical Engineering; Chongqing University; Chongqing 400044; People's Republic of China Department of Neurosurgery, General Hospital of People’s Liberation Army Chengdu Military Region, Chengdu 610083, China Key Laboratory for Biorheological Science and Technology of Ministry of Education (Chongqing University), Chongqing University Cancer Hospital and Chongqing Cancer Institute and Chongqing Cancer Hospital, Chongqing, China (mainland) Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX, USA CAMS Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China; Suzhou Institute of Systems Medicine Suzhou China State Key Laboratory of Molecular Biology, Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, the Chinese Academy of Sciences, Shanghai 200031, China. State Key Laboratory of Hydrology−Water Resources and Hydraulic Engineering, Hohai University, Nanjing 210098, China State Key Laboratory of Cancer Biology 1 , , , Xi’an 710032 , China; Department of Immunology 1 , , , Xi’an 710032 , China; Fourth Military Medical University 1 , , , Xi’an 710032 , China Chongqing Cancer Multi-omics Big Data Application Engineering Research Center, Chongqing University Cancer Hospital, Chongqing, China Fujian University Key Laboratory for Plant-Microbe Interaction and College of Plant Protection, Fujian Agriculture and Forestry University, Fuzhou, China Key Laboratory of Tropical Translational Medicine of Ministry of Education, Hainan Provincial Key Laboratory for Research and Development of Tropical Herbs, School of Pharmacy, Hainan Medical University, Haikou, 571199, China College of Environmental Science and Engineering, Guilin University of Technology, Guilin 541000, China College of Eco-Environmental Engineering, Guizhou Minzu University, Guiyang, Asia, China Beijing University of Chinese Medicine, No. 11, North Tird Ring East Road, Beijing, China Biotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences, Agricultural Biotechnology Key Laboratory of Yunnan Province, Kunming 650205, China Department of Endocrinology (T.Y., Y.S., X.H.), Jiangsu Diabetes Center, Nanjing Medical University, Nanjing 210029, People’s Republic of China Contribution from the State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P.R. China Department of Oncology, Hainan Branch of Chinese PLA General Hospital, Sanya, Hainan 572013, P.R. China Department of General Surgery, Tianjin First Center Hospital, Tianjin, China Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources Guangxi Normal University Guilin 541004 P. R. China Institute for Chemical Physics and Department of Chemistry, State Key Laboratory of Electrical Insulation and Power Equipment, Xi’an Jiaotong University, Xi’an 710049, China, and Fukui Institute for Fundamental Chemistry, Kyoto University, Kyoto 606-8103, Japan Departments of Neurosurgery, Department of Radiology, School of Medicine, Nantong University, Nantong, Jiangsu, PR China Nanoengineering Research Group Centre for Mechanical Technology and Automation (TEMA) Department of Mechanical Engineering University of Aveiro 3810-193 Aveiro Portugal College of Materials & Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310036, People’s Republic of China; Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials & Ministry of Educational Key Laboratory for the Synthesis and Application of Organic Functional, Molecules & College of Chemistry and Chemical Engineering, Hubei University, Wuhan 430062, People’s Republic of China; School of Physics, The University of Sydney, Camperdown, New South Wales 2006, Australia Department of Orthopaedics, Xiangya Hospital of Central South University, Changsha Hunan, 410008, P.R.China. The United Innovation of Mengchao Hepatobiliary Technology Key Laboratory of Fujian Province, Mengchao Hepatobiliary Hospital of Fujian Medical University, Fuzhou 350025, China Department of Medical Genetics Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College Beijing China School of Computer Science, University of Birmingham, Birmingham 35201, UK; Education Information Technology Center, China West Normal University, Nanchong 637002, China Department of Acupuncture, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100053, China From the Department of Infectious Diseases and Pathology, College of Veterinary Medicine (T.Y., M.Z., M.G., B.S., M.M.), Division of Gastroenterology, Hematology and Nutrition, Department of Medicine (T.Y., M.Z., M.G., B.S., M.M.), Department of Physiology and Functional Genomics (M.M.S., V.R., J.M.C., M.K.R.), College of Medicine, Division of Cardiovascular Medicine, Department of Medicine (V.R., Y.Q., C.J.P.), Division of Infectious Diseases and Global Medicine, Department of Medicine (E.L.), and... Department of General Surgery The First Affiliated Hospital of Jinzhou Medical University Jinzhou China Department of Chemical and Biological Engineering, Colorado School of Mines, Golden, Colorado 80401, United States Department of Chemistry; Southern University of Science and Technology; Shenzhen; P. R. China Department of Biotherapy and Hemo-oncology, Chongqing Cancer Institute, Chongqing 400030, China College of Pharmacy, Dalian Medical University, Dalian, Liaoning, China College of Life Sciences, South China Agricultural University, Guangzhou, Guangdong Province, China Institute of Crop Sciences, Chinese Academy of Agricultural Sciences, Beijing 100081, China Beijing National Laboratory for Molecular Sciences; Department of Polymer Science and Engineering and Key Laboratory of Polymer Chemistry and Physics of Ministry of Education; College of Chemistry; Peking University; Beijing 100871 School of Pharmacy, Health Science Center, Xi'an Jiaotong University , Xi'an, Shaanxi , China Acute Stroke Program, Neurology Division, University of Alberta Hospital, Edmonton, Alberta, Canada Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-Sen University, Guangzhou, Guangdong, China Chengdu Institute of Biology, the Chinese Academy of Sciences, Chengdu 610041, People's Republic of China, Graduate School of the Chinese Academy of Sciences, Beijing 100039, People's Republic of China, and Pharmaceutical Institute of Chengdu Di-Ao Pharmaceutical Group, Chengdu 610041, People's Republic of China College of Chemistry and Chemical Engineering, Ocean University of China, 266003, Qingdao, China From the Departments of Medicine and Pharmacology (P.Y., H.K., B.D., T.Y., J.W., P.C.V., K.T.M., K.N., A.L.G., D.M.R.), Vanderbilt University School of Medicine, Nashville, Tenn; Cardiology Division (S.H.H.), Johann Wolfgang Goethe University, Frankfurt, Germany; National Cardiology Center (W.S.), Osaka, Japan; Department of Cardiology (P.J.S.), Policlinico S. Matteo, Istituto di Ricovero e Cura a Carattere Scientifico, Pavia, Italy; and Medtronic Inc (M.S.), Minneapolis, Minn. Key Laboratory of Biofuels, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, China Department of Physiology and Functional Genomics, College of Medicine (E.M.R., T.Y., S.K., C.S., M.K.R.), University of Florida, Gainesville. Ningxia Key Laboratory of Information Sensing & Intelligent Desert, School of Physics and Electronic-Electrical Engineering, Ningxia University, Yinchuan 750021, China; State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Fudan University, Shanghai 200433, China Department of Vascular Surgery, Shanxi Bethune Hospital Taiyuan 030000, Shanxi Province, China. State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, and Chinese Academy of Sciences Beijing China Department of Molecular Nutrition; College of Food Science and Engineering; Central South University of Forestry and Technology; Changsha; PR China State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University , Harbin 150040 , China Department of General Surgery, Tangdu Hospital, Fourth Military Medical University, Xi'an, China. Collaborative Innovation Center of Assessment for Basic Education Quality, Beijing Normal University, Beijing 100875, China Department of Brain Disease, Gansu Province Chinese Traditional Medicine Hospital, Lanzhou, Gansu 730050, China From the Vanderbilt University School of Medicine, Departments of Medicine and Pharmacology, Nashville, Tenn. Department of Endocrinology and Metabolism The First Affiliated Hospital of Nanjing Medical University Nanjing China Department of Pharmacy Gansu Provincial Maternity and Child Care Hospital Lanzhou China Ministry of Education Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, Lanzhou, China Department of Physiology and Functional Genomics University of Florida Gainesville 32610 FL USA; Microbiome Consortium and Center for Hypertension and Precision Medicine, Department of Physiology and Pharmacology University of Toledo College of Medicine and Life Sciences Toledo Ohio 43606 Department of Urology, Tongji Hospital, School of Medicine Tongji University Shanghai China Robert S. Dow Neurobiology Laboratories, Legacy Research, Portland, OR 97232, USA. Key Laboratory of Standardization of Chinese Medicines of Ministry of Education, Institute of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Institute of Cardiovascular Disease of Integrated Traditional Chinese and Western Medicine, Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China CAS Key Laboratory for Carbon Materials Institute of Coal Chemistry Chinese Academy of Sciences Taiyuan 030001 China Chongqing Key Laboratory of Environmental Materials and Remediation Technologies College of Chemistry and Environmental Engineering Chongqing University of Arts and Sciences Chongqing 402160 China State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu 610041, China Laboratory of Molecular Nutrition; College of Food Science and Engineering; National Engineering Laboratory for Deep Processing of Rice and Byproducts; Central South University of Forestry and Technology; Changsha Institute of Burn Research, State Key Laboratory of Trauma, Burn and Combined Injury, Key Laboratory of Disease Proteomics of Chongqing, Southwest Hospital, Army Medical University, China Cancer Stem Cell Institute, Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine, Shanghai 200120, China Fachbereich Chemie Philipps-Universität Marburg Hans-Meerwein-Strasse 4 35043 Marburg Germany Key Laboratory of Chinese Internal Medicine of Ministry of Education and Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing 100700, China Institute of Burn Research; State Key Laboratory of Trauma, Burn and Combined Injury; Key Laboratory of Proteomics of Chongqing; Southwest Hospital; Army Medical University (Third Military Medical University) International Sci. & Tech. Cooperation Base of Energy Materials and Application, College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014, P.R. China China National GeneBank, BGI , Shenzhen 518083 , China Department of Cardiology, the First Affiliated Hospital, Harbin Medical University, 23 Youzheng Street, Nangang District, Harbin 150001, China State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China 3 Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, 1100 Fairview Ave. N., Seattle, Washington 98109, USA State Key Laboratory of Hydrology-Water Resources and Hydraulic Engineering, Center for Global Change and Water Cycle, Hohai University, Nanjing 210098, China College of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang 414006, China Center for Pulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing. [email protected] Department of Respiratory and Critical Care Medicine, Affiliated People's Hospital of Jiangsu University, Zhenjiang, Jiangsu 212001, P.R. China Department of Orthopedics Joint Disease Area College of Sciences; Nanjing Tech University; Nanjing 211816; P. R. China Center for Advanced Optoelectronic Materials, College of Materials & Environmental Engineering, Hangzhou Dianzi University, Hangzhou, 310018, P. R. China Department of Molecular and Human GeneticsBaylor College of MedicineHoustonTXUSA The Institute for Advanced Studies, Wuhan University, Wuhan 430072, China Life Sciences Institute and Department of Cell and Developmental Biology , University of Michigan , Ann Arbor , MI , USA Department of Critical Care Medicine Beijing Tiantan Hospital, Capital Medical University Beijing China; Department of Critical Care Medicine Fu Xing Hospital, Capital Medical University Beijing China First Central Clinical College of Tianjin Medical University,Tianjin,China; Oriental Organ Transplant Center of Tianjin First Central Hospital,Tianjin,China; Key Laboratory of Organ Transplantation of Tianjin,Tianjin,China School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001, China MOE Key Laboratory of Crop Heterosis and Utilization/Beijing Key Laboratory of Crop Genetic Improvement, College of Agronomy and Biotechnology China Agricultural University Beijing China Department of Endocrinology the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing China Department of Public Health and Department of Hematology of First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310058, China; Zhejiang University Cancer Center, Hangzhou 310058China School of Biological and Chemical Engineering, Panzhihua University, Panzhihua 617000, P. R. China Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China Department of Adult Cardiac Surgery, Fuwai Hospital Chinese Academy of Medical Sciences Beijing China School of Chemical Engineering; Sichuan University; Chengdu 610065; China; School of Biological and Chemical Engineering Hunan Institute of Food Quality Supervision Inspection and Research, Changsha, Hunan, People's Republic of China Institute for Chemical Physics & Department of Chemistry State Key Laboratory of Electrical Insulation and Power Equipment Xi'an Jiaotong University Xi'an 710049 China Institute for Carbon Neutrality University of Science and Technology Beijing 100083 Beijing China Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China State Key Laboratory of Advanced Metallurgy; University of Science and Technology Beijing; Beijing 100083, China Department of Endocrinology and Metabolism, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China Laboratory of Anti-inflammation and Immunopharmacology, Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai 201203 , China; School of Pharmacy, University of Chinese Academy of Sciences , Beijing 100049 , China School of Chemical Engineering and Australian Centre for Nanomedicine (ACN) The University of New South Wales (UNSW Sydney) Sydney NSW 2052 Australia School of Pharmacy, Chengdu University, Chengdu, PR China State Key Laboratory of Biotherapy; West China Hospital; West China Medical School; Sichuan University; Chengdu, PR China Departments of Chemical Enzymology, Medicinal Chemistry, and Cancer Research, Bristol–Myers Squibb Company, Experimental Station, Wilmington, DE 19880; and Mitotix, Incorporated, One Kendall Square, Building 600, Suite 622, Cambridge, MA 02139 Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital Third Military Medical University, Chongqing Institute of Hypertension Chongqing China From the Department of Physiology and Functional Genomics, College of Medicine (M.M.S., S.K., C.T.C.-J., G.O.L., M.K.R.), Division of Cardiovascular Medicine, Department of Medicine (Y.Q., C.S.S., C.J.P.), Department of Physiological Sciences, College of Veterinary Medicine (J.Z., T.Y., F.G.-P., R.D.J.), Department of Pharmacodynamics, College of Pharmacy (V.S.), J. Crayton Pruitt Family Department of Biomedical Engineering (D.C.S., C.S.S.); Mechanical and Aerospace Engineering, Herbert Wertheim... Department of Urinary Surgery, Hebei General Hospital Shijiazhuang, Hebei, China. b Chengdu Institute of Biology, Chinese Academy of Sciences , Chengdu , 610041 , P. R. China Department of Chemistry; University of Hawaii at Manoa; Honolulu; USA China ENFI Engineering Corporation, Beijing 100038, P. R. China; National Engineering Research Center of Silicon-based Materials Manufacturing Technology, Luoyang 471023, P. R. China Dali Bai Autonomous Prefecture People's Hospital Dali China Key Laboratory of Advanced Technologies of Materials Ministry of Education School of Materials Science and Engineering Southwest Jiaotong University Chengdu 610031 P. R. China National Engineering Laboratory for Rice and By-Product Deep Processing; Central South University of Forestry and Technology; Hunan Province 410004 People's Republic of China Department of Traditional Chinese Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China. Beijing Integrative Medicine on Encephalopathy Research Institution, Beijing 100070, China. Department of Orthopaedic Oncology, Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangzhou China Chengdu Institute of Biology, the Chinese Academy of Sciences, Chengdu 610041, People's Republic of China, and Graduate School of the Chinese Academy of Sciences, Beijing 100039, People's Republic of China Department of Pharmacy Chinese PLA General Hospital Beijing China; College of Pharmacy Chengdu University of Traditional Chinese Medicine Chengdu China Jiangsu Key Laboratory of Translational Research and Therapy for Neuro‐Psycho‐Diseases College of Pharmaceutical Sciences Soochow University Suzhou 215123 Jiangsu China Department of Neurology & Neurological Sciences, Stanford University School of Medicine, Stanford, CA 94305-5122, USA Key Laboratory of Advanced Technologies of Materials (Ministry of Education), School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu, Sichuan 610031, P. R. China Division of Mood Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China; Department of Psychiatry, University of British Columbia, Vancouver, British Columbia, Canada State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing, 100193, China Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, P. R. China, Research Center, Chengdu Medical College, Chengdu 610083, P. R. China, and University of Chinese Academy of Sciences, Beijing 100039, P. R. China Division of Cardiovascular Surgery, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan, Shanxi 030032, China Department of Oncology, Hainan Hospital of People's Liberation Army General Hospital, Sanya, Hainan 572013, P.R. China State Key Laboratory of Precision Spectroscopy, East China Normal University, Shanghai 200062, P.R. China; Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan, Shanxi 030006, P.R. China Department of Chemistry; University of Hawaii at Manoa; Honolulu, USA Institute for Chemical Physics & Department of Chemistry, Xi’an Jiaotong University, Xi’an 710049, China; Institute for Molecular Science, Okazaki 444-8585, Japan From Vanderbilt University School of Medicine, Departments of Medicine and Pharmacology, Nashville, Tenn. Department of Clinical Pharmacology, College of Pharmacy, Dalian Medical University School of Chemistry and Molecular Engineering, East China Normal University, No. 500 Dongchuan Road, Shanghai 200241, China State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, P. R. China, and Graduate School of the Chinese Academy of Sciences, Beijing 100039, P. R. China Key Laboratory of Dairy Science; Ministry of Education; College of Food Science; Northeast Agricultural University; Harbin Jiangsu Chunlan Clean Energy Research Institute Co.; Ltd.; Taizhou 225300; China Department of Medical Genetics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, WHO Collaborating Centre for Community Control of Hereditary Diseases, Beijing, P.R. China. Department of Orthopaedic Surgery Lishui Central Hospital and Fifth Affiliated Hospital of Wenzhou Medical College Lishui China Collaborative Innovation Center of Steel Technology University of Science and Technology Beijing Beijing 100083 P. R. China Chongqing Rapeseed Technology Research Center, Chongqing Key Laboratory of Crop Quality Improvement, Key Laboratory of Biotechnology and Crop Quality Improvement of Ministry of Agriculture, College of Agronomy and Biotechnology, Southwest University, 216 Tiansheng Road, Beibei, Chongqing, 400716, People’s Republic of China. Department of Endocrinology, The First Affiliated Hospital with Nanjing Medical University, Nanjing Medical University, Nanjing, 210029, China Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China Department of Physiology and Pharmacology, College of Medicine and Life Sciences, Center for Hypertension and Precision Medicine University of Toledo Toledo Ohio USA Department of Neurosurgery Kyoto University Graduate School of Medicine Kyoto Japan; Department of Clinical Innovative Medicine Kyoto University Graduate School of Medicine Kyoto Japan School of Acupuncture and Massage, Henan College of TCM, Zheng-zhou 450008, China. [email protected] Department of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai, PR China; Agency for Science, Technology and Research (A*STAR),Institute for Infocomm Research (I2R),Singapore,138632 Innovation Center of NanoMedicine, Kawasaki Institute of Industrial Promotion, 3-25-14 Tonomachi, Kawasaki-ku, Kawasaki 210-0821, Japan Department of Nephrology; Haidian Hospital of Beijing City, Beijing 100080, China. National Technique Innovation Center for Regional Wheat Production/Key Laboratory of Crop Physiology, Ecology and Management, Ministry of Agriculture/National Engineering and Technology Center for Information Agriculture, Nanjing Agricultural University, Nanjing, Jiangsu 210095, People’s Republic of China Research Center for Computational Science Institute for Molecular Science Myodaiji Okazaki 444–8585 Japan; Elements Strategy Initiative for Catalysts and Batteries (ESICB) Kyoto University Kyoto 615–8510 Japan Department of Orthopaedics Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Guangzhou Guangdong China Department of Psychiatry, Jining Psychiatric Hospital, Jining, Shandong, China (mainland) Institute of Educational Statistics and Measurement, Beijing Normal University; Key Laboratory of Semiconductor Materials Science, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China; College of Materials Science and Optoelectronic Technology, University of Chinese Academy of Sciences, Beijing 100049, China Electronic Information School, Wuhan University, Wuhan 430072, China. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, People's Republic of China; Key Laboratory of Medicinal Chemistry and Molecular Diagnosis, Ministry of Education, and College of Chemistry and Environmental Science, Hebei University, Baoding 071002, People's Republic of China The First Clinical Medical School Southern Medical University Guangzhou Guangdong China; Department of Medical Oncology National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Colorectal and Anal Surgery, The Second Hospital of Jilin University, Changchun, Jilin 130012, P.R. China Cancer Center; West China Hospital; West China Medical School; Sichuan University; Chengdu From the Departments of Medicine and Pharmacology (H.W., T.Y., D.M.S., J.S.L., T.C.A., D.W.W., B.L., L.H., S.K., N.K., B.C.K., A.L.G., D.M.R.) and Molecular Physiology and Biophysics (S.B.H., M.A.M.), Vanderbilt University School of Medicine, Nashville, TN; Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan (H.W.); Division of Cardiology, University of Toronto, Canada (L.H.); Department of Medicine, The First Affiliated Hospital of Nanjing... Department of Orthopaedics Surgery, Southwest Hospital, Third Military University, Chongqing 400038, China. Research Centre of Plant Protection, Yunnan Institute of Tropical Crops, Jinghong 666100, China Laboratory of Basic Research in Biomass Conversion and Utilization; Department of Thermal Science and Energy Engineering; University of Science and Technology of China; Hefei 230026; PR China Eco-Materials and Renewable Energy Research Center (ERERC); Collaborative Innovation Center of Advanced Microstructures; College of Engineering and Applied Sciences; Nanjing University; Nanjing 210093 Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China College of Materials Science and Engineering, Northeast Forestry University, Harbin 150040, P. R. China Eco-materials and Renewable Energy Research Center (ERERC); Collaborative Innovation Center of Advanced Microstructures; College of Engineering and Applied Sciences; Nanjing University; Nanjing 210093 Vanderbilt University Medical Center, Nashville TN (A.M.G., G.D., C.M.S., E.H.F.-E., T.Y., A.M., J.D.M., S.L.V.D., Q.S.W., L.L.S., O.R.K., Y.W., H.T.B., Z.T.Y., D.W.M., B.M.K., W.-Q.W., M.B.S., D.M.R.). College of Animal Science and Technology, Hunan Agriculture University, Changsha, Hunan, China CAS Key Laboratory of Carbon Materials Institute of Coal Chemistry Chinese Academy of Sciences Taiyuan 030001 Shanxi P.R. China; University of Chinese Academy of Sciences Beijing 100049 P.R. China School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529000, PR China Graduate School, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing, China Key Laboratory of Economic Plants and Biotechnology and Yunnan Key Laboratory for Wild Plant Resources, Chinese Academy of Sciences, Kunming 650201, People’s Republic of China Department of Cardiology, Internal Medicine, Changsha Central Hospital, Changsha, Hunan 410011, China Department of Orthopaedics, People's Hospital of Jingjiang, Jingjiang, China Institute of Cardiovascular Disease, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. Department of Endocrinology and Metabolism Jiangsu Province Hospital Nanjing China Department of Burns and Cutaneous Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi 710032, China; First Student Brigade, Fourth Military Medical University, Xi’an, Shaanxi 710032, China Institute of Drug Discovery Technology, Ningbo University, Ningbo 315211, China; Qian Xuesen Collaborative Research Center of Astrochemistry and Space Life Sciences, Ningbo University, Ningbo 315211, China School of Materials Science and Engineering, Central South University of Forestry and Technology, Changsha 410011, Hunan China Yuhang Center for Disease Control and Prevention, Yuhang 311100, China. a Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, 400037, China Tianjin Reseach Institute of Acute Abdominal Diseases, Tianjin 300100, China. Department of Public Health Emergency Management, Yuhang Center for Disease Control and Prevention, Hangzhou 311100, China. From Sino-German Laboratory for Molecular Medicine (Y.W., W.Z., C.Z., Y. Zheng, Y. Zhen, K.S., C.F., T.Y., J.W., J.S., R.H.), Hypertension Division (Y. Zhang, H.W., R.H.), Department of Cardiology (Y.Y., J.C., R.H.), and Department of Cardiovascular Surgery (L.S., S.H), Fuwai Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College and National Genome Center (Beijing); and Division of Basic Medical Sciences (W.C.G.), Mercer University School of Medicine, Macon, Ga. State Key Laboratory of Materials-Oriented Chemical Engineering, Jiangsu National Synergetic Innovation Center for Advanced Materials, College of Chemistry and Chemical Engineering, Nanjing Tech University, Nanjing 211816, China Fachbereich Chemie, Philipps-Universität Marburg, Marburg D-35032, Germany Authors' Affiliations: 1Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China; and 2Department of Molecular Carcinogenesis, the University of Texas MD Anderson Cancer Center, Science Park, Smithville, Texas SydPath, St Vincent’s Hospital Sydney, Darlinghurst, New South Wales, Australia Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing 400042, China Department of Pharmacy, The Fifth Medical Center of PLA General Hospital, Beijing 100039, China; College of Clinical Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China Maize Research Institute, Sichuan Agricultural University, Chengdu 611130, China From the Departments of Pharmacology (S.S.C., H.W., T.Y., T.P.Z., D.M.R.) and Medicine (D.M.S., T.P.Z., D.M.R.), Physiology and Biophysics (K.S.W.), and Cell & Developmental Biology (T.P.Z.) and Center for Human Genetics Research (J.S.B.), Vanderbilt University School of Medicine, Nashville, Tenn; and Cardiovascular Research Center (C.G.B.), Massachusetts General Hospital, Boston. Department of Chemistry, University of Hawaii at Manoa, Honolulu, Hawaii 96822, United States Department of Neurosurgery, Ankang Central Hospital, Ankang 725000, People's Republic of China The 93313 Army of Chinese People's Liberation Army Changchun Jilin China From the Departments of Medicine (S.K., T.Y., M.E.A., M.A.M., D.M.R.), Pharmacology (S.K., T.Y., M.E.A., D.M.R.), and Molecular Physiology & Biophysics (K.D.N., M.A.M.), Vanderbilt University School of Medicine, Nashville, Tenn, and Department of Cell Biology and Anatomy (A.W.), Medical University of South Carolina, SC. Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, People’s Republic of China College of Pharmacy, Hainan Medical University, Haikou, China CAS Key Laboratory of Carbon Materials Institute of Coal Chemistry Chinese Academy of Sciences Taiyuan 030001 Shanxi P.R. China; Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing 100049 P.R. China Department of Cardiac Surgery, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China Jiangsu Key Laboratory of Advanced Catalytic materials and technology; Changzhou University; Changzhou; China Department of Biliary and Pancreatic Surgery/Cancer Research Center Affiliated Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, China The National Population and Health Scientific Data Centre (Clinical Medicine); Department of Pathology Future Technology School Shenzhen Technology University Shenzhen 518118 P. R. China Department of Critical Care Medicine; Fu Xing Hospital; Capital Medical University; Beijing China Sino-German Laboratory for Molecular Medicine, The Key Laboratory for Clinical Cardiovascular Genetics, FuWai Cardiovascular Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100037, China Center for Molecular Systems and Organic Devices (CMSOD), Key Laboratory for Organic Electronics and Information Displays & Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China Department of Surgery, The Dumont-UCLA Transplant Center, Division of Liver and Pancreas Transplantation, David Geffen School of Medicine at UCLA, Los Angeles, California, USA; Department of Infectious Diseases, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China School of Biotechnology and Health Science, Wuyi University, Jiangmen 529020, Guangdong, China Xinjiang Product Quality Supervision and Inspection Research Institute Urumqi China Institutes of Physical Science and Information Technology and Centre for Atomic Engineering of Advanced Materials Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education Department of Chemistry and Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials Anhui University Hefei Anhui 230601 China Research Center for Translational Medicine, East Hospital, Tongji University School of Medicine, Shanghai, P. R. China; Department of Pharmacology, School of Basic Medicine, Hebei Medical University, Shijiazhuang, P. R. China Department of Biochemistry & Molecular Biology Shanxi Medical University Taiyuan China; Key Laboratory of Cellular Physiology (Shanxi Medical University) Ministry of Education Taiyuan China State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, PR China Department of Nuclear Medicine,PUMC Hospital,CAMS and PUMC,Beijing 100730,China. Protein & Peptide Pharmaceutical Laboratory, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Beijing 100101, China Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences Soochow University Suzhou 215123 China Department of Endocrinology The First Affiliated Hospital of Nanjing Medical University Nanjing China Key Laboratory of Advanced Technologies of Materials (Ministry of Education), School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, P. R. China a Center for Natural Products Research , Chengdu Institute of Biology of the Chinese Academy of Sciences , Chengdu 610041 , People's Republic of China College of Biological Sciences and Technology, Beijing Forestry University, Beijing 100083, China Hospital and Institute of Hepatobiliary Surgery, Chinese PLA General Hospital, Beijing 100853, China College of Chemistry and Chemical Engineering; Chongqing University; Chongqing 400044; P. R. China State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, China Beijing Advanced Innovation Center for Materials Genome Engineering, Collaborative Innovation Center of Steel Technology, University of Science and Technology Beijing, Beijing 100083, China Attending Doctor, Department of Anesthesiology and Intensive Care Medicine, Changhai Hospital, Second Military Medical University, Shanghai, PR China. State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, and Collaborative Innovation Center for Biotherapy, Chengdu 610041, China Department of Adult Joint Reconstructive Surgery【?】, Yangpu Hospital, Shanghai Tongji University, Shanghai, 200090, P.R.China. Program in Skeletal Disease and Tumor Microenvironment, Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, Michigan Biotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences/Agricultural Biotechnology Key Laboratory of Yunnan Province, Kunming 650205, China State Key Laboratory of Photocatalysis on Energy and Environment; College of Chemistry; Fuzhou University; Fuzhou; China Department of Medical Genetics, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine Peking Union Medical College Beijing China Julong College, Shenzhen Technology University, Shenzhen 518118, China; Centre for Mechanical Technology and Automation, Department of Mechanical Engineering, University of Aveiro, 3810-193 Aveiro, Portugal The Key Laboratory of Veterinary Public Health, Ministry of Agriculture, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, P.R. China. Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong; Department of Anatomical and Cellular Pathology, The Chinese University of Hong Kong, Prince of Wales Hospital, Hong Kong Guang'anmen Hospital, China Academy of TCM, Beijing 100053. Department of Cardiovascular Medicine; Department of Emergency Medicine, the Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. Department of Cell Biology, Van Andel Institute, Grand Rapids, Michigan 49503, USA. State Key Laboratory of Optoelectronic Materials and Technologies, Guangdong Province Key Laboratory of Display Material and Technology, School of Electronics and Information Technology, Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University and Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou 510006, People’s Republic of China Center for Molecular Discovery, Verna and Marrs McLean Department of Biochemistry and Molecular Biology and; Department of Molecular and Cellular Biology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030; and Department of Orthopedic, Tianjin Hospital, Tianjin, China Department of Joint Surgery and Sports Medicine, Tianjin Union Medical Center, Tianjin 300121, P.R. China Department of Endocrinology (T.Y.), The First Hospital affiliated to Nanjing Medical University, Nanjing, 210029 Jiangsu, China From the Stroke Research Laboratory, Department of Medicine (Neurology), University of Alberta, Edmonton, Alberta, Canada. *State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China;; †University of Chinese Academy of Sciences, Beijing 100049, China; State Key Laboratory for Mineral Deposits Research; School of Earth Sciences and Engineering; Nanjing University; Nanjing 210093; P. R. China Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Road, Pudong New Area, Shanghai 201203, China College of Telecommunications and Information Engineering Nanjing University of Posts and Telecommunications Nanjing Jiangsu China Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, Peopleʼs Republic of China, Department of Physics, Peking University, 100871, Peopleʼs Republic of China, and X-ray Laboratory, China University of Geoscience, Beijing, 100083, Peopleʼs Republic of China Department of Joint Surgery, The First Affiliated Hospital of Dalian Medical University, Dalian, P. R. China Department of Dermatology and Venereology, Candidate Branch of National Clinical Research Centre for Skin and Immune Diseases, The First Affiliated Hospital of Gannan Medical University, Ganzhou, China Department of Neurobiology and Collaborative Innovation Center for Brain Science, School of Basic Medicine, Fourth Military Medical University, Xi’an 710032, China Department of Joint and Sport Medicine, Tianjin Union Medical Center, China Department of Urinary Surgery, Hebei General Hospital, Shijiazhuang, Hebei, China (mainland) Department of Otorhinolaryngology‐Head and Neck Surgery Xinhua Hospital Shanghai Jiaotong University School of Medicine Shanghai China; Ear Institute Shanghai Jiaotong University School of Medicine Shanghai China School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an 710061, P. R. China Britton Chance Center for Biomedical Photonics, Huazhong University of Science and Technology, Wuhan National Laboratory for Optoelectronics, 1037 Luoyu Road, Wuhan 430074, ChinabHuazhong University of Science and Technology, Department of Biomedical Engi Department of Cardiology Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai China; Shanghai Key Laboratory of Traditional Chinese Clinical Medicine Shanghai China Department of Oncology, Huangshi Central Hospital of Edong Healthcare, Affiliated Hospital of Hubei Polytechnic University, Huangshi, Hubei 435000, P.R. China Department of Orthopaedics Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences Guangzhou China Department of Drug Analysis, Faculty of Pharmacy, Xinjiang Medical University, Urumqi 830011, China; Central Laboratory of Xinjiang Medical University, Urumqi 830011, China State Key Laboratory of Coordination Chemistry School of Chemistry and Chemical Engineering Nanjing University Nanjing 210023 P. R. China Neuroscience Institute Morehouse School of Medicine Atlanta GA USA Department of Emergency, The Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China Department of Materials Science; School of Chemistry and Chemical Engineering; Nantong University; Nantong; P. R. China State Key Laboratory of Biotherapy/Collaborative Innovation Center of Biotherapy and Cancer Center, West China Hospital of Sichuan University, Chengdu, 610041, China The First Affiliated Hospital with Nanjing Medical University Jiangsu Province Hospital Nanjing China Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture, Microbiology Department, College of Life Sciences, Nanjing Agricultural University, Nanjing, Jiangsu, People's Republic of China Department of General Surgery , First Affiliated Hospital of Jinzhou Medical University , Jinzhou 121000 , China Department of Neurology and Neurological Sciences, Stanford University, Palo Alto, CA, USA Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA. Neurobiology, Stanford University School of Medicine, Stanford, CA, USA Fachbereich Chemie; Philipps-Universität Marburg; Marburg 35032; Germany The Institute for Advanced Studies, Wuhan University, 299 Bayi Road, Wuhan 430072, China Department of Urology, Hebei Provincial People’s Hospital, Shijiazhuang, 050000 Hebei, China Department of Breast Surgery Gansu Provincial Maternity and Child Care Hospital Lanzhou China Key Laboratory of Microelectronics Devices & Integrated Technology, Institute of Microelectronics of Chinese Academy of Sciences (IMECAS), Beijing 100029, China; Microelectronics Institute, University of Chinese Academy of Sciences, Beijing 100049, China School of Materials Science and Engineering Zhejiang University Hangzhou China Institute for Chemical Physics & Department of Chemistry; State Key Laboratory of Electrical Insulation and Power Equipment; Xi'an Jiaotong University; Xi'an 710049, China Key Laboratory of Advanced Technologies of Materials (Ministry of Education), School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China Department of Chemistry University of Hawaii at Manoa Honolulu HI 96822 USA Jining Medical University Jining China Department of Oncology, Hainan Hospital of Chinese People's Liberation Army General Hospital, Sanya, Hainan 572013, P.R. China Department of Oncology Hainan Hospital of Chinese People's Liberation Army General Hospital Sanya China Robert S. Dow Neurobiology Laboratories, Legacy Clinical Research and Technology Center, Portland, Oregon, USA School of Mechanical Engineering, Beijing Institute of Technology, Beijing 100081, China Province Key Laboratory for Fine Petrochemical Catalysis and Separation, College of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology, Yueyang, Hunan 414000, P. R. China The MOE Key Laboratory for Standardization of Chinese Medicines and The SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, The Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine 201210 Shanghai PRC; Shanghai R&D Centre for Standardization of Chinese Medicines 201210 Shanghai PRC; Institute of Liver Diseases Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine 201210 Shanghai PRC State Key laboratory for Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China Department of Mechanical Engineering, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong From the Department of Medicine (T.C.A., D.M.S., H.W., T.Y., L.H., J.S.L., B.L., P.Y.), Molecular Physiology (S.B.H., M.A.M.), and Biophysics (S.B.H., M.A.M.) and the Department of Pharmacology (D.M.R.), Vanderbilt University School of Medicine, Nashville, Tennessee. Department of Endocrinology Jiangsu Province Hospital Nanjing China State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China Department of Neurosurgery, Chengdu Military General Hospital, Chengdu, Sichuan, China Department of Infectious Diseases and Pathology University of Florida Gainesville FL USA; Division of Gastroenterology, Hepatology & Nutrition Department of Medicine University of Florida Gainesville FL USA Neurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Zhujiang Hospital, Southern Medical University , Guangzhou 510282, China Department of Gastrointestinal Surgery Tianjin First Central Hospital Nankai District Tianjin China Institute for Molecular Science; Research Center for Computational Science; Myodaiji; Japan; Elements Strategy Initiative for Catalysts and Batteries (ESICB) The First Affiliated Hospital of Nanjing Medical University Nanjing China Biotechnology and Genetic Resources Institute, Yunnan Academy of Agricultural Sciences, Kunming 650205, China State Key Laboratory of Cardiovascular Disease, Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Neurobiology, Morehouse School of Medicine, Atlanta, USA 2School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia; 3Saint Vincent’s Clinical School, UNSW Sydney, Sydney, Australia; 4SydPath, Saint Vincent’s Hospital, Sydney, Australia State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun 130022, P. R. China Department of Infection and Liver Diseases, Liver Research Center, The First Affiliated Hospital of Wenzhou Medical College, Wenzhou, Zhejiang 325000, PR China. Key Laboratory of Carbon Materials, Institute of Coal Chemistry, Chinese Academy of Sciences, Taiyuan030001, China School of Information Engineering and Robot Technology Used for Special Environment Key Laboratory of Sichuan Province, Southwest University of Science and Technology , Mianyang, 621010, China Department of Biochemistry and Molecular Biology, Shanxi Medical University, Taiyuan, China From the Departments of Medicine (J.R., T.Y., Y.W., M.E.A., D.M.R.), Pharmacology (W.Z., C.S., H.K., M.E.A., S.K., D.M.R.), Pediatrics (J.T., P.F.), Pathology (J.B.A.), and Biomedical Engineering (P.K.), Vanderbilt University School of Medicine, Nashville, Tenn; and the Academic Medical Center (E.E.V.), University of Amsterdam, Task Force Heart Failure and Aging, Department of Physiology, The Netherlands. Xi'an Jiaotong University Institute for Chemical Physics and Department of Chemistry, State Key Laboratory of Electrical Insulation and Power Equipment, , Xi'an 710049, China Department of Neurosurgery, Ankang Central Hospital, Ankang, Shaanxi 725000, P.R. China Department of Emergency, Sun Yat-sen Memorial Hospital, Sun Yat-sen University Guangzhou 510000, Guangdong, China. Department of Medicine (Y.W., T.Y., C.M.S., L.L.D., A.M.G., G.E.D.), Vanderbilt University Medical Center, Nashville, TN. Department of Cardiovascular Disease, ShuGuang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China. Department of Neurosurgery Affiliated Hospital of Zunyi Medical University Zunyi Guizhou China Key Laboratory of Organofluorine Chemistry Laboratory; Shanghai Institute of Organic Chemistry; Shanghai; China Shenzhen Grubbs Institute and Department of Chemistry, Southern University of Science and Technology, Shenzhen, Guangdong 518055, China State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Regeneron Pharmaceuticals, Inc., Tarrytown, NY 10591; School of Emergency Management and Safety Engineering, China University of Mining & Technology, Beijing 100083, China; Safety Engineering, North China University of Science and Technology, Tangshan 063210, China From the Departments of Neurology and Neurological Sciences (J.H., J.P., T.Y., M.R.S., K.P.D., K.T.-L., E.C., A.H., J.Z.G., B.J., F.M.L., M.S.B.) and Neurosurgery (J.H., J.P., M.R.S., K.P.D., K.T.-L., E.C., A.H., J.Z.G., B.J., M.S.B.), Stanford University School of Medicine, Stanford, CA; the Department of Psychiatry (D.J.), Weill Cornell Medical College, New York, NY; and the Department of Neurology and Laboratory for Computational Neurochemistry and Drug Discovery (S.M.M.), Department of Veteran's... Center for X-Mechanics, School of Aeronautics and Astronautics, Zhejiang University, Hangzhou, China.; Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province, Hangzhou, China. Shanxi Changzhi Blood Center Changzhi Shanxi China Department of Mathematical Sciences, Clemson University, Clemson, SC, USA Institute of Human Virology, Key Laboratory of Tropical Disease Control of Ministry of Education, Guangdong Engineering Research Center for Antimicrobial Agent and Immunotechnology, Zhongshan School of Medicine, Sun Yat-sen University, 510080, Guangzhou, Guangdong, China; State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China; Laboratory of Human Disease and Immunotherapies, West China Hospital, Sichuan University, Chengdu 610041, China State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, P.R. China Hospital of Stomatology, Guanghua School of Stomatology, Guangdong Provincial Key Laboratory of Stomatology, Sun Yat-sen University, Guangzhou 510050, China From the Department of Neurosurgery, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. Institute of Cancer, Xinqiao Hospital, Third Military Medical University, Chongqing, China School of Materials Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310027, P. R. China Department of Physiology and Functional Genomics (H.-B.L, T.Y., E.M.R., M.K.R.), College of Medicine, University of Florida, Gainesville; Microbiome Consortium and Center for Hypertension and Precision Medicine, Department of Physiology and Pharmacology, College of Medicine and Life Sciences, University of Toledo, OH (T.Y.). Department of Joint and Sport Medicine, Tianjin Union Medical Center, Tianjin, China. College of Chemistry and Environmental Engineering, Jiujiang University, Jiujiang 332005, China Department of Molecular and Human Genetics, State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou Fujian 350002 China Department of Otorhinolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China. [email protected]. Ear Institute, Shanghai Jiaotong University School of Medicine, Shanghai, China. [email protected]. Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China. [email protected]. College of Chemistry and Chemical Engineering, Chongqing University, 174 Shazhengjie Street, Chongqing 400044, People’s Republic of China Institute for Molecular Science, Okazaki 444-8585, Japan Department of Medicine (J-E.S., T.Y., J.J.M., B.C.K., A.M.G., D.M.R.), Vanderbilt University Medical Center, Nashville, TN.; Department of Pharmacology (J-E.S., T.Y., B.C.K., D.M.R.), Vanderbilt University Medical Center, Nashville, TN. Faculty of Life Science and Technology Kunming University of Science and Technology Kunming 650500 P. R. China From the Department of Medicine and Pharmacology (T.Y., W.Z., P.Y., D.M.R.), Oates Institute for Experimental Therapeutics, Vanderbilt University School of Medicine, Nashville, Tenn; Institute of Life Science (S.-K.C., J.G.L.M., M.I.R.), School of Medicine, Swansea University, Swansea, United Kingdom; the Department of Molecular Medicine and Pathology (C.H.M., J.K.F.), Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; Cardiac Inherited Disease Group (J.C., J.M.,... Institute for Chemical Physics & Department of Chemistry State Key Laboratory of Electrical Insulation and Power Equipment, Xi'an Jiaotong University Xi'an 710049 China Departments of Medicine, Pharmacology and Biomedical Informatics Vanderbilt University Medical Center Nashville TN Department of Chemical Pathology, Chinese University of Hong Kong, Hong Kong, China. [email protected] Affiliated Hospital of Municipal Institute of Traditional Chinese Medicine of Changzhi City , Changzhi, Shanxi , China CAS Key Laboratory of Carbon Materials Institute of Coal Chemistry Chinese Academy of Sciences Taiyuan 030001 P.R. China; University of Chinese Academy of Sciences Beijing 100049 P.R. China Independent researcher; Morgantown; USA College of Veterinary Medicine, National Reference Laboratory of Veterinary Drug Residues (SCAU), South China Agricultural University, Guangzhou, China Department of Chemistry, Shanghai University, 99 Shang-Da Road, Shanghai 200444, China Department of Otolaryngology‐Head and Neck Surgery The Second Xiangya Hospital, Central South University Changsha China Department of Cardiovascular Surgery State Key Laboratory of Cardiovascular Disease Fu Wai Hospital and Cardiovascular Institute National Center for Cardiovascular Diseases Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China State Key Joint Laboratory of Environmental Simulation and Pollution Control & School of Environment, Beijing Normal University, 100875 Beijing, China International Research Center for EM Metamaterials and Institute of Advanced Magnetic Materials, Hangzhou Dianzi University, Hangzhou, 310018, China From Vanderbilt University Medical Center, Nashville, Tenn. Discipline of Pathology, University of Western Sydney School of Medicine, Liverpool, NSW, Australia.; Cancer Pathology and Cell Biology Laboratory, Ingham Institute of Applied Medical Research, Liverpool, NSW, Australia.; Department of Anatomical Pathology, Liverpool Hospital, Sydney South West Area Pathology Service, Liverpool, NSW, Australia. School of Information Technology, Nanjing University of Chinese Medicine, Nanjing, China; National Engineering Laboratory for Rice and Byproduct Process, Faculty of Food Science and Engineering Center South University of Forestry and Technology Changsha 410004 China Department of Oral and Maxillofacial Surgery, General Hospital of Shenyang Military Area Shenyang 110016, China. Institute of Hematology, The Second Hospital of Shanxi Medical University, Taiyuan, China. Department of Medical Oncology, National Cancer Center/National Clinical Research Center for Cancer /Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Chengdu Institute of Cultural Relics and Archaeology, Shierqiao road No.18, Chengdu 610072, Sichuan China Biotechnology and Genetic Resources Institute, Yunnan Academy of Agricultural Sciences/Agricultural Biotechnology Key Laboratory of Yunnan Province, Kunming 650205, China College of Chemistry and Chemical Engineering; Chongqing University; Chongqing, People's Republic of China Department of Urology, Hebei General Hospital, Shijiazhuang, Hebei 050051, P.R. China Center for Cancer and Cell Biology, Van Andel Research Institute, Grand Rapids, Michigan 49503, United States Key Laboratory of Genome Research and Genetic Improvement of Xinjiang Characteristic Fruits and Vegetables, Institute of Horticultural Crops, Xinjiang Academy of Agricultural Sciences, Urumqi 830091, China School of Basic Medicine, Gansu University of Traditional Chinese Medicine, Lanzhou, Gansu 730000, P.R. China State Key Laboratory of Advanced Metallurgy; University of Science and Technology Beijing; China Bioinformatics and Genomics Program, Pennsylvania State University, University Park, PA, USA. Laboratory of High Pressure Physics and Material Science (HPPMS), School of Physics and Physical Engineering, Qufu Normal University, Qufu, Shandong 273165, China; Institute of Advanced Materials, School of Electromechanical and Automobile Engineering, Huanggang Normal University, Huanggang, Hubei 438000, China Outpatient Department of Oral and Maxillofacial Surgery, Beijing Stomatological Hospital, School of Stomatology Capital Medical University Beijing China State Key Laboratory of Urban Water Resource and Environment, School of Environment, Harbin Institute of Technology, Harbin 150090, China Department of Biliary and Pancreatic Surgery/Cancer Research Center Affiliated Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Department of Physiology and Functional Genomics College of Medicine University of Florida Gainesville FL Department of Clinical Laboratory, Chengde Central Hospital, Chengde, 067000, China University of Science and Technology of China 1 Hefei National Laboratory for Physical Sciences at Microscale and Department of Modern Physics, , Hefei, Anhui 230026, China; University of Science and Technology of China 2 CAS Center for Excellence and Synergetic Innovation Center in Quantum Information and Quantum Physics, , Hefei, Anhui 230026, China School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China Department of Medical GeneticsInstitute of Basic Medical Sciences, Chinese Academy of Medical Sciences & School of Basic Medicine, Peking Union Medical College Beijing China Institute of Liver Diseases, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Zhangheng Road, Zhangjiang Hi-Tech Park, Shanghai 201210, China Department of Neurology, University of Michigan, Ann Arbor, MI, USA Xi’an International Medical Center Hospital School of Psychology, Guizhou Normal University, Guiyang, China; Center for Big Data Research in Psychology, Guizhou Normal University, Guiyang, China Department of Biochemistry and Molecular Biology, School of Basic Medicine; Key Laboratory of the Cell physiology, Shanxi Medical University, Taiyuan 030001, China. *Corresponding author, E-mail: [email protected]. State Key Laboratory of Materials-Oriented Chemical Engineering Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM) College of Chemical Engineering Nanjing Tech University Nanjing 211816 China From the Center for Hypertension and Metabolic Diseases, Department of Hypertension and Endocrinology, Daping Hospital, Third Military Medical University, Chongqing Institute of Hypertension, Chongqing, China. College of Materials & Environmental Engineering; Hangzhou Dianzi University; Hangzhou 310018; China Department of Endocrinology and Metabolism, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China Department of Neurosurgery, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital, Capital Medical University; Department of Neurosurgery, Ankang Central Hospital, Ankang, People’s Republic of China China National GeneBank, BGI Research , Shenzhen 518120 , China Key Laboratory of Microgravity, Institute of Mechanics, Chinese Academy of Sciences 1 , Beijing 100190, People's Republic of China Department of Thoracic Surgery the First People's Hospital of Longquanyi District Chengdu Chengdu China Institute for Chemical Physics and Department of Chemistry, Xi’an Jiaotong University, Xi’an 710049, China State Key Laboratory for Mineral Deposits Research, School of Earth Sciences and Engineering Nanjing University Nanjing 210093 P.R.China; Collaborative Innovation Center of South China Sea Studies Nanjing University Nanjing 210093 P.R.China Department of Anesthesiology, The First Affiliated Hospital of Wenzhou Medical University Wenzhou 325000, Zhejiang, P. R. China. 1Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China Department of Cardiovascular Medicine, Changsha Central Hospital, China State Key Laboratory of Pharmaceutical Biotechnology, School of Life Sciences, Nanjing University, Nanjing 210023, P. R. China State Key Laboratory of Structural Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou Fujian 350002 P. R. China; College of Physics Qingdao University Qingdao 266071 P. R. China Fachbereich Chemie, Philipps-Universität Marburg, Hans-Meerweinstrasse 4, 35032 Marburg, Germany Department of Neurosurgery, China National Clinical Research Center for Neurological Diseases, Beijing Tiantan Hospital; and School of Biotechnology and Health Science, Wuyi University, Jiangmen 529020, China College of Materials Science and Engineering; Zhejiang University; Hangzhou; China School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, 710061, P.R. China Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing, Jiangsu 210029, China State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun 130022, Jilin Province, People's Republic of China Key Laboratory for Biorheological Science and Technology of Ministry of Education (Chongqing University), Chongqing University Cancer Hospital, Chongqing, China Department of Neurology, Chengdu Military General Hospital, Chengdu, China. Verna and Marrs McLean Department of Biochemistry and Molecular Biology and Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, Texas 2School of Medicine, Western Sydney University, Campbelltown, New South Wales, Australia; 4Saint Vincent’s Clinical School, UNSW Sydney, Sydney, Australia; 5SydPath, Saint Vincent’s Hospital, Sydney, Australia Department of Chemistry, University of Hawai’i at Ma̅noa, Honolulu, Hawaii 96822, United States State Key Laboratory for Conservation and Utilization of Subtropical Agro-Bioresources, Guangdong Key Laboratory for Innovative Development and Utilization of Forest Plant Germplasm, College of Forestry and Landscape Architecture, South China Agricultural University, Guangzhou 510642, China School of P.E and Sport Training, Shanghai University of Sport, Shanghai, China Neuroscience Institute Morehouse School of Medicine Atlanta Georgia USA College of Chemistry and Chemical Engineering, Hunan Institute of Science and Technology Department of Cellular and Molecular Physiology, Hershey, PA 17033, USA School of Physical Education and Health, Linyi University, Linyi, China Department of Chemistry, University of Hawai’i at Manoa, Honolulu, Hawaii 96822, United States Department of Pharmacy, Hubei Province Key Laboratory of Occupational Hazard Identification and Control, Institute of Infection, Immunology and Tumor Microenvironments, Medical College, Wuhan University of Science and Technology, Wuhan 430065, China Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University; Nanjing; P. R. China Shanghai Urban and Rural Construction and Traffic Development Research Institute, Shanghai 200234, China Otolaryngology,; Interdisciplinary PhD Program in Genetics, and; Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai 200092, People's Republic of China; The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China The First Affiliated Hospital of Nanjing Medical University Nanjing, China. Department of Computer Science and Engineering, Arizona State University, Tempe, AZ 85287, USA. [email protected]. Department of Traditional Chinese Medicine Beijing Tiantan Hospital Capital Medical University Beijing China Key Laboratory of Chinese Internal Medicine, Ministry of Education and Beijing; Laboratory for Integrated Traditional Chinese and Western Medical Research of Qi-Blood Jiangsu Province Hospital, Gulou District, Nanjing, China Cancer Institute Xuzhou Medical University Xuzhou China; Center of Clinical Oncology The Affiliated Hospital of Xuzhou Medical University Xuzhou China; Jiangsu Center for the Collaboration and Innovation of Cancer Biotherapy, Cancer Institute Xuzhou Medical University Xuzhou China The CT laboratory, School of Mathematical Sciences, Capital Normal University, Beijing, China Key Laboratory of Animal Genetics, Breeding and Reproduction in the Plateau Mountainous Region; Cell and Molecular Biology (PhD); Animal Department; Guizhou University; Guiyang 550025 Yantai Marine Economic Research Institute, Yantai 264003, China St. Vincent's Hospital Sydney Australia Biomedical Informatics Research Lab, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China; Cancer Genomics Research Center, School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China; Big Data Research Institute, China Pharmaceutical University, Nanjing 211198, China Key Laboratory of Advanced Technologies of Materials (Ministry of Education) School of Materials Science and Engineering Southwest Jiaotong University Chengdu 610031 P. R. China Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China, Structural Chemistry, Stockholm University, SE-10691 Stockholm, Sweden, and State Key Laboratory of Magnetic Resonance and Atomic and Molecular Physics, Wuhan Institute of Physics and Mathematic, Chinese Academy of Sciences, Wuhan 430071, China Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University, Nashville, TN 37232; School of Materials Science and Engineering, Zhejiang University, Hangzhou, 310027 Zhejiang, P. R. China Department of Hematology and Oncology, Dongzhimen Hospital, the First Clinical Medical College of Beijing University of Chinese Medicine, Beijing, China Changhai Hospital, Second Military Medical University, Shanghai, PR China (X.D.). [email protected]. School of Chemical Engineering Huaihai Institute of Technology Lianyungang 222005 China School of Materials Science and Engineering, Zhejiang University, Hangzhou, 310058, P. R. China Key Laboratory of Sensor Analysis of Tumor Marker of Education Ministry, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, P. R. China Division of Clinical Pharmacology, Department of Medicine (A.M.G., T.Y., D.R.), Vanderbilt University Medical Center, Nashville, TN.; Department of Pharmacology (T.Y., D.R.), Vanderbilt University Medical Center, Nashville, TN. Department of Endocrinology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment, Chongqing University Cancer Hospital, Chongqing Cancer Institute, Chongqing Cancer Hospital, Chongqing, China Institute of Materials, Ningbo University of Technology, Ningbo 315016, People’s Republic of China; State Key Laboratory of Advanced Metallurgy, University of Science and Technology Beijing, Beijing 100083, People’s Republic of China National Energy Technology Laboratory, Morgantown, West Virginia 26505, United States; Leidos Research Support Team, Morgantown, West Virginia 26507, United States College of Mechanical and Electrical Engineering, Nanjing University of Aeronautics and Astronautics 2 , Nanjing 210016, China; Jiangsu Key Laboratory of Precision and Micro-Manufacturing Technology 3 , Nanjing 210016, China State Key Laboratory of Cardiovascular Disease, Center of Pulmonary Vascular Disease, Fuwai Hospital, National Center for Cardiovascular Disease, Chinese Academy of Medical Sciences and Peking Union Medical College, North Lishi Road, Xicheng District, No. 167, Beijing, 100037, China Institute of Horticultural Crops, Xinjiang Academy of Agricultural Science (Key Laboratory of Horticulture Crop Genomics Research and Genetic Improvement in Xinjiang), Urumqi, Xinjiang, China Department of Neurosurgery, The First People's Hospital of Huzhou (First Affiliated Hospital of Huzhou University), Huzhou, Zhejiang 313000, P.R. China State Key Laboratory of Biotherapy and Cancer Center, West China Hospital Sichuan University, and Collaborative Innovation Center for Biotherapy, West China Hospital West China Medical School, Sichuan University Chengdu Sichuan 610041 P. R. China Science and Technology Park, Guangzhou University of Chinese Medicine, Guangdong, People’s Republic of China Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, PR China; Hubei Institute of Urology, Wuhan 430030, PR China; Department of Urology, Jingzhou Central Hospital, The Second Clinical Medical College, Yangtze University, Jingzhou 434020, PR China State Key Laboratory Base of Eco-chemical Engineering, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, College of Pharmaceutical Sciences, Soochow University, Suzhou 215123, China Institute of Liver Diseases Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine Shanghai China Department of Endocrinology and Metabolism, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China Research Center for Computational Science, Institute of Molecular Science, 38 Nishigo-Naka, Myodaiji, 444-8585 Okazaki, Japan East China Normal University School of Chemistry and Molecular Engineering CHINA Department of Hematology‐Oncology Chongqing University Cancer Hospital Chongqing China Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, Peopleʼs Republic of China, and Structural Chemistry, Stockholm University, SE-10691 Stockholm, Sweden Department of Anatomical Pathology South Western Sydney Area Pathology Service, Liverpool Sydney NSW Australia; Faculty of Medicine Discipline of Pathology, School of Medicine, University of Western Sydney NSW Australia Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, China; Ear Institute, Shanghai Jiao Tong University School of Medicine, Shanghai 200125, China; Shanghai Key Laboratory of Translational Medicine on Ear and Nose diseases, Shanghai 200125, China Ministry of Education, Key Laboratory of Cell Activities and Stress Adaptations, School of Life Sciences, Lanzhou University, 222 Tianshui Road, Lanzhou 730000, China Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China Faculty of Life Science and Technology, Kunming University of Science and Technology Department of Dermatovenerology, The First Affiliated Hospital of Gannan Medical University, Ganzhou City, China State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, China; Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University, Chengdu, China Department of Cardiology, Center for Diagnosis and Management of Pulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China College of Intelligent Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610000, Sichuan, China; Xin-Huangpu Joint Innovation Institute of Chinese Medicine, Guangzhou 510000, Guangdong, China From the Department of Medicine and Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN. Institute of Horticulture Crops Xinjiang Academy of Agricultural Sciences Urumqi 830091 P. R. China Department of Physiology and Pain Research Center, Zhongshan Medical School, Sun Yat-Sen University, 74 Zhongshan Rd. 2, Guangzhou, 510080, PR China Shenzhen Grubbs Institute and Department of Chemistry; Southern University of Science and Technology; Shenzhen; People's Republic of China Research Center of Clinical Medical Affiliated Hospital of Nantong University Nantong China; Department of Pharmacy Affiliated Hospital of Nantong University Nantong China Beijing National Laboratory for Molecular Sciences, State Key Laboratory for Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, People's Republic of China, and Physics Department, Graduate School of Science, Tohoku University, Sendai 980-8578, Japan Department of Infectious Disease, The First Hospital Affiliated with Nanjing Medical University, Jiangsu Province Hospital, Nanjing, Jiangsu 210029, P.R. China Northeast Operation Branch of Chongqing Expressway Group Co., Ltd., Chongqing 401120, China Department of Physiological Sciences; College of Veterinary Medicine; University of Florida; Gainesville Florida SydPath, St Vincent’s Hospital Sydney, Darlinghurst, NSW, Australia.; School of Medicine, Western Sydney University, Campbelltown, NSW, Australia. Breast Cancer Center, Shandong Cancer Hospital, Jinan 250117, China. Department of Molecular Microbiology and Immunology Oregon Health & Science University Portland Oregon USA Institute of Cardiovascular Disease of Integrated Traditional Chinese and Western Medicine, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China School of Materials Science and Engineering; Zhejiang University; Hangzhou; China Hunan Key Laboratory of Processed Food for Special Medical Purpose College of Food Science and Engineering Central South University of Forestry and Technology Changsha 410004 P. R. China Hospital of Stomatology, Guanghua School of Stomatology, Sun Yat-sen University and Guangdong Provincial Key Laboratory of Stomatology, Guangzhou, 510055, People’s Republic of China State Key Laboratory of Precision Spectroscopy, School of Physics and Electronic Science, East China Normal University, Shanghai 200241, China Department of Neurosurgery, National Cerebral and Cardiovascular Center, Suita, Osaka; Key Laboratory of Sensor Analysis of Tumor Marker of Education Ministry; College of Chemistry and Molecular Engineering; Qingdao University of Science and Technology; Qingdao 266042; P. R. China Department of Dermatology, Daping Hospital Army Medical University Chongqing China; Chongqing Engineering Research Center of Organ Intelligent Bio‐Manufacturing Chongqing China Department of Neurosurgery, the First Affiliated Hospital of USTC, Division of Life Science and Medicine, University of Science and Technology of China, Hefei, China; Department of Neurosurgery, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei, China Laboratory of Molecular Nutrition; College of Food Science and Engineering; National Engineering Laboratory for Rice and Byproduct Deep Processing; Central South University of Forestry and Technology; Changsha Department of Medicine, Division of Clinical Pharmacology, Vanderbilt Center for Arrhythmia Research and Therapeutics (A.M.G., B.M.K., T.Y., Y.W., T.S., J.-E.S., D.M.R.), Vanderbilt University Medical Center, Nashville, TN. Department of General surgery First Affiliated Hospital of Jinzhou Medical University Jinzhou China School of Chemistry and Molecular Engineering; East China Normal University; Shanghai 200241; China College of Chemical Engineering, China University of Mining and Technology, Xuzhou 221116, P. R. China From the Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, Tenn. Department of Medicine, Vanderbilt University Medical Center , 2215B Garland Ave, 1285 MRBIV, Nashville, TN 37232 , USA Ecole Polytechnique Fédérale de Lausanne (EPFL) From the Departments of Medicine, Pharmacology, and Anesthesiology, Vanderbilt University School of Medicine, Nashville, Tenn. Laboratory of Human Disease and Immunotherapies, West China Hospital, Sichuan University, Chengdu, China The Department of Endocrinology and Metabolism, First Affiliated Hospital of Nanjing Medical University , 300 Guangzhou Road, 210029 Nanjing , China Jiangsu Province Hospital Jiangsu China The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Department of Endocrinology The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing China Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu, China Program of Skeletal Disease and Tumor MetastasisCenter for Cancer and Cell BiologyVan Andel Research InstituteGrand RapidsMIUSA Department of Materials Science and Engineering, City University of Hong Kong, Hong Kong SAR 00000, China Medicine (T.Y., J.D.M., J.D.B., J-E.S., Q.S.W., L.S., M.A.B., C.S., T.J.W., B.C.K., D.M.R.), Vanderbilt University, Nashville, TN. Institute for Chemical Physics and Department of Chemistry, State Key Laboratory of Electrical Insulation and Power Equipment, Xi’an Jiaotong University, Xi’an 710049, China Department of Gastroenterology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang Uygur Autonomous Region 830000, China Department of Hematology Oncology Chongqing University Cancer Hospital, Chongqing Key Laboratory of Translational Research for Cancer Metastasis and Individualized Treatment Chongqing China Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province; Department of Engineering Mechanics; Zhejiang University; Hangzhou; China Department of Joint Surgery, Yangpu Hospital Affiliated to Tongji University, Shanghai, China Department of Emergency, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi 330000, China Ministry of Education Key Laboratory of Sustai-nable Forest Ecosystem Management, Northeast Forestry University, Harbin 150040, China. Department of Gastrointestinal Surgery, Binzhou Medical University Hospital, No. 661 Huanghe 2nd Road, Binzhou City, 256603 Shandong Province, China College of Science, Nanjing Agricultural University, Nanjing 210095, P. R. China School of Chemical Engineering and Technology, Sun Yat-Sen University, Zhuhai 519082, China Key Laboratory of Green-Chemistry Materials in University of Yunnan Province, Yunnan Minzu University, Kunming 650500, P. R. China Gastro-Intestinal Viral Oncology Group, Ingham Institute for Applied Medical Research, Liverpool, New South Wales, Australia; South Western Sydney Clinical School, University of New South Wales, Kensington, New South Wales, Australia; SydPath, St Vincent’s Hospital Sydney, Darlinghurst, New South Wales, Australia The First Affiliated Hospital School of Medicine Shihezi University Shihezi Xinjiang 832008 China Internal Department, the First Hospital, Hebei Medical University, Shijiazhuang 050031, Hebei Province, China. Department of Molecular and Human Genetics, Baylor College of Medicine, and The First Affiliated Hospital of Nanjing Medical University, Nanjing, China Department of Urology First Affiliated Hospital of Xi’an Jiaotong University Xi’an, Shaanxi China Department of Orthopedic Surgery The Fifth Affiliated Hospital of Wenzhou Medical University, Affiliated Lishui Hospital of Zhejiang University, Lishui Municipal Central Hospital 289 Kuocang Road Lishui 323000 China Key Laboratory of Semiconductor Materials Science, Institute of Semiconductors, Chinese Academy of Sciences, P.O. Box 912, Beijing 100083, People’s Republic of China Chengdu Institute of Biology, The Chinese Academy of Sciences, Chengdu 610041, People's Republic of China, and Graduate School of the Chinese Academy of Sciences, Beijing 100039, People's Republic of China Department of Traditional Chinese Medicine Beijing Tiantan Hospital, Capital Medical University; Beijing Integrative Medicine on Encephalopathy Research Institution, Beijing Tiantan Hospital Capital Medical University Department of Surgery and Urology, Hebei General Hospital, Shijiazhuang, China Key Laboratory of Chinese Internal Medicine of the Ministry of Education, Dongzhimen Hospital Affiliated to Beijing University of Chinese Medicine, Beijing 100700, China State Key Laboratory of Coordination Chemistry, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, P. R. China; Chemistry and Biomedicine Innovation Center, Nanjing University, Nanjing 210023, P. R. China Department of Chemistry, University of Liverpool, Liverpool, L69 7ZD, United Kingdom The First Affiliated Hospital of Nanjing Medical University (Jiangsu Province People's Hospital) Jiangsu China Department of Endocrinology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, China, and X-ray Laboratory, China University of Geoscience, Beijing 100083, China The Institute for Advanced Studies Wuhan University Wuhan 430072 China 1Key Laboratory of Synthetic Biology Regulatory Elements, Institute of Systems Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China; 2Suzhou Institute of Systems Medicine, Suzhou, China Animal Health Research Institute, Tongwei Co., Ltd., Chengdu, People’s Republic of China Department of Gastrointestinal Surgery Tianjin First Central Hospital Tianjin China Xi'an Jiaotong University 1 Institute for Chemical Physics and Department of Chemistry, State Key Laboratory of Electrical Insulation and Power Equipment, , Xi'an 710049, China Department of Endocrinology, The First Affiliated Hospital with Nanjing Medical University, Nanjing, Jiangsu, China Southwest University of Science and Technology School of Information Engineering and Robot Technology Used for Special Environment Key Laboratory of Sichuan Province, , Mianyang 621010, China Department of Joint and Sports Medicine, Tianjin Union Medical Center, Tianjin 300121, P.R. China Julong College, Shenzhen Technology University, Shenzhen 518118, China Bethune Hospital Affiliated to Shanxi Medical University, Shanxi Bethune Hospital, Taiyuan, China Neurosurgery Department The First Affiliated Hospital of Jinan University Guang Dong Guangzhou China Human Science of Sport Qufu Normal University Qufu China State Key Laboratory of Mycology; Institute of Microbiology; Chinese Academy of Sciences; Beijing China Department of Hepatobiliary Surgery, The First Hospital of Shangjiazhuang City, Shijiazhuang City, Hebei Province 050011, China Institute for Chemical Physics & Department of Chemistry, State Key Laboratory of Electrical Insulation and Power Equipment; Xi'an Jiaotong University; Xi'an 710049 China for the H-REPLACE Investigators Department of Neurosurgery, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui 230001, P.R. China National Key Laboratory of Veterinary Biotechnology and Animal Influenza Laboratory of the Ministry of Agriculture, Harbin Veterinary Research Institute of Chinese Academy of Agricultural Sciences, Harbin 150001, China. Department of Anesthesiology Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou China Centre for Kidney Disease Research, School of Medicine, The University of Queensland at Princess Alexandra Hospital, Brisbane, QLD 4102, Australia; Discipline of Pathology, School of Medicine, University of Western Sydney, Sydney, NSW 2751, Australia Department of Urology First Affiliated Hospital of Xi'an Jiaotong University Xi'an China College of Horticulture and Landscape Architecture, Northeast Agricultural University, Harbin 150030, China; Key Laboratory of Cold Region Landscape Plants and Applications, Harbin 150030, China Information Engineering University Guangxi Key Laboratory of Regenerative Medicine, Orthopaedic Department The First Affiliated Hospital of Guangxi Medical University Nanning Guangxi China; Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co‐constructed by the Province and Ministry, Life Sciences Institute, Guangxi Medical University Nanning Guangxi China Department of Mechanical Engineering City University of Hong Kong Hong Kong SAR China State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, Jilin 130022, People's Republic of China, and Graduate School of the Chinese Academy of Sciences, Beijing 100039, People's Republic of China School of Biological Science and Medical Engineering, Beihang University, Beijing, China; Inner Mongolia People’s Hospital, Hohhot, Inner Mongolia, China State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, Sichuan, PR. China. [email protected] State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School, Sichuan University, Chengdu 610041, China Laboratory of Natural and Targeted Small Molecule Drugs, State Key Laboratory of Biotherapy and Cancer Center and Collaborative Innovation Center of Biotherapy, West China Hospital of Sichuan University, Chengdu 610041, China From the Department of Physiology and Functional Genomics (R.K.S., T.Y., A.C.O., G.O.L., V.A., S.K., E.M.R., C.S., M.K.R.), College of Medicine, University of Florida, Gainesville. State Key Laboratory of Mycology; Institute of Microbiology; Chinese Academy of Sciences; Beijing China; University of Chinese Academy of Sciences; Beijing China Changchun Institute of Applied Chemistry State Key Laboratory of Electroanalytical Chemistry, , Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun 130022, China Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China. Department of Joint Surgery The First Affiliated Hospital of Dalian Medical University Dalian China Departments of Physiology and Biophysics, Cell and Neurobiology, and Ophthalmology, School of Medicine, and Department of Pharmaceutical Sciences, School of Pharmacy, University of Southern California, Los Angeles, California 90033; and Institut für Physiologische Chemie, Fachbereich Medzin, Johannes Gutenberg-Universität Mainz, Mainz, Germany Department of General and Digestive Surgery, Unit of Innovation in Minimally Invasive Surgery, University Hospital "Virgen del Rocio", University of Seville, Seville, Spain Neurosurgery Center, Department of Cerebrovascular Surgery, The National Key Clinical Specialty, The Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease, Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration, The Neurosurgery Institute of Guangdong Province, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China Institute of Human Virology Zhongshan School of Medicine Sun Yat‐sen University Guangzhou Guangdong China; Key Laboratory of Tropical Disease Control of Ministry of Education Zhongshan School of Medicine Sun Yat‐sen University Guangzhou Guangdong China Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, and College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu 215123, China Translational Programs in Stroke, Neuroscience Institute, Morehouse School of Medicine, Atlanta GA Department of General Surgery, The First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, Xinjiang 832008, P.R. China Key Laboratory of Sensor Analysis of Tumor Marker of Education Ministry, Shandong Provincial Key Laboratory of Biochemical Analysis, College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, 53 Zhengzhou Road, Qingdao 266042, P. R. China State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, West China Medical School Sichuan University Chengdu Sichuan China; Laboratory of Human Diseases and Immunotherapy, West China Hospital, West China Medical School Sichuan University Chengdu Sichuan China; Institute of Immunology and Inflammation, Frontiers Science Center for Disease‐Related Molecular Network, West China Hospital, West China Medical School Sichuan University Chengdu Sichuan China Department of Endocrinology the First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital Nanjing 210029 China Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture; Microbiology Department, College of Life Sciences, Nanjing Agricultural University , Nanjing, China Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China Department of Neurosurgery Center The National Key Clinical Specialty The Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration The Neurosurgery Institute of Guangdong Province Zhujiang Hospital Southern Medical University Guangzhou 510282 China Department of Endocrinology, The First Affiliated Hospital, Nanjing Medical University, Nanjing, China. School of Materials Science and Engineering Zhejiang University Hangzhou Zhejiang 310027 China Department of Orthopedics, 4th (Xing Yuan) Hospital of Yulin, Yulin City, Shaanxi Province, 719000, China School of Materials Science and Engineering; Zhejiang University; Hangzhou; P. R. China Department of Otolaryngology Head and Neck Surgery, The Second Xiangya Hospital, Central South University Changsha 410011, Hunan, PR China. Department of Traditional Chinese Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; Beijing Integrative Medicine on Encephalopathy Research Institution, Beijing, China Department of Endocrinology and Metabolism, the First Affiliated Hospital with Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, China Department of Plastic Surgery, the First Affiliated Hospital of Zhengzhou University, Zhengzhou Henan, 450052, P.R.China. Department of Otolaryngology Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine , Shanghai , China; Ear Institute, Shanghai Jiao Tong University School of Medicine , Shanghai , China; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases , Shanghai , China Laboratory of Natural and Targeted Small Molecule Drugs, State Key Laboratory of Biotherapy and Cancer Center, Collaborative Innovation Center of Biotherapy, West China Hospital of Sichuan University, Chengdu 610041, China Department of Otorhinolaryngology—Head and Neck Surgery Xinhua Hospital, Shanghai Jiaotong University School of Medicine Shanghai China; Ear Institute Shanghai Jiaotong University School of Medicine Shanghai China Department of Endocrinology, First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Key Laboratory of Agricultural Environmental Microbiology, Ministry of Agriculture; Microbiology Department, College of Life Sciences Nanjing Agricultural University Nanjing Jiangsu 210095 China Huazhong University of Science and Technology, Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics, Wuhan 430074, ChinabHuazhong University of Science and Technology, Department of Biomedical Engineering, Key Labo Sino-German Laboratory for Molecular Medicine &Key Laboratory for Clinical Cardiovascular Genetics, Ministry of Education, Cardiovascular Institute &FuWai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Hefei National Laboratory for Physical Sciences at Microscale and Department of Modern Physics, University of Science and Technology of China, Hefei, Anhui 230026, People's Republic of China; and Department of Neurosurgery, Kyoto University Graduate School of Medicine, Kyoto; and University of Nanjing School of Medicine Nanjing China Jiangsu Key Laboratory of Translational Research and Therapy for Neuro‐Psycho‐Diseases College of Pharmaceutical Sciences Soochow University Suzhou 215123 China Center for Skeletal Diseases and Tumor MetastasisVan Andel Research InstituteGrand RapidsMI 49503USA Department of Chemistry, National University of Singapore, 12 Science Drive 2, Singapore 117549, Republic of Singapore College of Materials and Chemical Engineering; State Key Laboratory of Marine Resource Utilization in South China Sea; Hainan University; Haikou 570228; China Department of Physiology and Pharmacology, College of Medicine and Life Sciences, The University of Toledo, (T.Y.). College of Environmental & Energy Engineering, Beijing University of Technology, Beijing 100022, P.R. China State Key Laboratory for Mineral Deposits Research and Center for Marine Geochemistry Research, Department of Earth Sciences Nanjing University Nanjing 210093 P.R. China Department of Pathophysiology and High Altitude Physiology, the Third Military Medical University, Chongqing, China. Key Laboratory of Plant Resources Conservation and Sustainable Utilization, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou, China; Key Laboratory of Microbial Resources Exploitation and Application Lanzhou, 730000, China; Institute of Biology Gansu Academy of Sciences, Lanzhou 730000, China Department of Oncology, The First People's Hospital of Lianyungang, Lianyungang, Jiangsu, China. State Key Laboratory of Advanced Metallurgy; University of Science and Technology Beijing; Beijing 100083; China The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu, China. State Key Laboratory of Biotherapy/Collaborative Innovation Center for Biotherapy, West China Hospital, West China Medical School, Sichuan University, Chengdu, Sichuan 610041, China Department of Traditional Chinese Medicine Beijing Tiantan Hospital Affiliated to Capital Medical University Beijing China Department of Infectious Diseases, Fifth Medical Center of Chinese PLA General Hospital National Clinical Research Center for Infectious Diseases Beijing China; Medical School of Chinese PLA Beijing China Key Laboratory of Environmental and Applied Microbiology, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu 610041, People’s Republic of China School of Materials Science and Engineering, Zhejiang University, Hangzhou 310058, Zhejiang, China Department of Gastrointestinal Surgery Binzhou Medical University Hospital Binzhou China Laboratory of Basic Research in Biomass Conversion and Utilization; Department of Thermal Science and Energy Engineering; University of Science and Technology of China; Hefei 230026; China Laboratory of Skeletal Biology, Van Andel Research Institute, Grand Rapids, MI 49503; College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, People's Republic of China; The Key Laboratory of Veterinary Public Health, Ministry of Agriculture, State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin 150001, People's Republic of China Department of Clinical Laboratory Affiliated Yixing People’s Hospital Jiangsu University Wuxi China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu China Department of Medical Cosmetology, Suzhou, Jiangsu, People’s Republic of China Beijing Normal University College of Food Science and Engineering, Northwest A&F University, Yangling 712100, Shaanxi, China Key Laboratory of Eco-chemical Engineering (Ministry of Education), College of Chemistry and Molecular Engineering, Qingdao University of Science and Technology, Qingdao 266042, China Program in Physiological Genomics, Microbiome Consortium and Center for Hypertension and Precision Medicine, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio Chinese Academy of Fishery Sciences Yellow Sea Fisheries Research Institute, , 106 Nanjing Road, Qingdao 266071, People’s Republic of China; Function Laboratory for Marine Fisheries Science and Food Production Processes, Pilot National Laboratory for Marine Science and Technology (Qingdao) , 1 Wenhai Road, Aoshanwei, Jimo, Qingdao 266200, People’s Republic of China Key Laboratory of Cell Activities and Stress Adaptations, Ministry of Education, School of Life Sciences, Lanzhou University, Lanzhou, China School of Biotechnology and Health Science, Wuyi University, Jiangmen 529020, Guangdong Province, China College of Materials & Environmental Engineering; Hangzhou Dianzi University; Hangzhou 310036; People's Republic of China Shanghai Jiao Tong University Institute of Theoretical Physics, , Shanghai 200240, China Department of Chemistry, University of Liverpool, Liverpool L69 7ZD, United Kingdom Jiangsu Key Laboratory of Neuropsychiatric Diseases College of Pharmaceutical Sciences Soochow University Suzhou 215123 China State Key Laboratory of Robotics, Shenyang Institute of Automation, Chinese Academy of Sciences, Shenyang 110016, China; Institutes for Robotics and Intelligent Manufacturing, Chinese Academy of Sciences, Shenyang 110169, China; University of Chinese Academy of Sciences, Beijing 100049, China; Beijing Institute of Precision Mechatronics and Controls, Beijing 100076, China; Laboratory of Aerospace Servo Actuation and Transmission, Beijing 100076, China Cancer Stem Cell Institute, Research Center for Translational Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, People's Republic of China The First Affiliated Hospital of Nanjing Medical University, China (T.Y.). Department of General Surgery, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121001, China State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Graduate School of the Chinese Academy of Sciences, Chinese Academy of Sciences, Changchun 130022 China Jiangsu Key Laboratory of Artificial Functional Materials; National Laboratory of Solid State Microstructures; Collaborative Innovation Center of Advanced Microstructures; Eco-Materials and Renewable Energy Research Center (ERERC); College of Engineering and Applied Sciences Henan Provincial Key Laboratory of Ion Beam Bioengineering, School of Physics and Engineering, Zhengzhou University, Zhengzhou 450052, China; Key Laboratory of Materials Physics of Ministry of Education, School of Physics and Engineering, Zhengzhou University, Zhengzhou 450052, China Research Center for Biological Therapy,Institute of Translational Hepatology,Beijing 302 Hospital,Beijing,China Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, Nanjing 210023, China Center of Pulmonary Vascular Disease State Key Laboratory of Cardiovascular Disease Fuwai Hospital National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China School of Materials Science and Engineering, Zhejiang University, Hangzhou, Zhejiang 310058, P. R. China State Key Laboratory of Agricultural MicrobiologyCollege of Animal Sciences and TechnologyHuazhong Agricultural UniversityWuhanChina; The Cooperative Innovation Center for Sustainable Pig ProductionWuhanChina; Hubei Provincial Engineering Laboratory for Pig Precision Feeding and Feed Safety TechnologyWuhanChina; National Center for International Research on Animal Genetics, Breeding and ReproductionWuhanChina State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China; Department of Dental Implant Center, Beijing Stomatological Hospital, School of Stomatology, Capital Medical University, Beijing 100050, China Key Laboratory of Environmental and Applied Microbiology, Chengdu Institute of Biology, Chinese Academy of Sciences, Chengdu, Sichuan 610041, People’s Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China Organ Transplantation Department Tianjin First Central Hospital Tianjin 300192 China; Tianjin Key Laboratory of Organ Transplantation Tianjin 300192 China Department of Endocrinology and Metabolism The First Affiliated Hospital with Nanjing Medical University 300 Guangzhou Road Nanjing China Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine Shanghai China Robert S. Dow Neurobiology Laboratories, Legacy Research, Portland, Oregon, USA College of Earth and Environment, Anhui University of Science and Technology, Huainan 232001, China. Department of Hematology of First Affiliated Hospital, and Department of Public Health, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China College of Electronic and Optical Engineering, Nanjing University of Posts and Telecommunications, Nanjing 210023, China Department of Chemical Pathology, Chinese University of Hong Kong, China. Institute of Human Virology, Sun Yat-sen University, Guangzhou, China; Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, Jiangsu, China College of Pharmacy, Provincial and State Key Laboratory Breeding Base of System Research, Development and Utilization of Chinese Herbal Medicine Resources, Chengdu University of Traditional Chinese Medicine, Chengdu, China; Department of Pharmacy, Fifth Medical Center, General Hospital of Chinese PLA, Beijing, China Department of Computational Medicine and Bioinformatics Institute of High Energy Physics, Chinese Academy of Sciences 1 , Beijing 100049, China; Spallation Neutron Source Science Center 2 , Dongguan 523803, China; University of Chinese Academy of Sciences 3 , Beijing 100049, China Institute of Materials, Ningbo University of Technology, Ningbo 315016, P.R. China; State Key Laboratory of Advanced Metallurgy, University of Science and Technology Beijing, Beijing 100083, P.R. China Cancer Center; West China Hospital; Sichuan University; Collaborative Innovation Center for Biotherapy; Chengdu Jiangnan University-Lidu Liquor Industry (Yuan Dynasty) Ancient Cellar Microbial Joint Research and Development Center, Jiangxi Lidu Liquor Industry Co., Ltd., Nanchang, Jiangxi 331725, China Beijing Engineering Research Center of Printed Electronics, Institution Beijing Institute of Graphic Communication Beijing 102600 P. R. China School of Medicine, Western Sydney University, Campbelltown, Australia.; Saint Vincent's Clinical School, UNSW Sydney, Sydney, Australia.; SydPath, Saint Vincent's Hospital, Sydney, Australia. Key Laboratory of Chinese Internal Medicine of Ministry of Education and Dongzhimen Hospital Beijing University of Chinese Medicine Beijing China School of Mechatronics and Intelligent Manufacturing, Huanggang Normal University, Huanggang 438000, China The First Affiliated Hospital with Nanjing Medical University, Jiangsu Province Hospital Nanjing China The Ministry of Education Key Laboratory for Standardization of Chinese Medicines and the SATCM Key Laboratory for New Resources and Quality Evaluation of Chinese Medicines, The Institute of Traditional Chinese Medicine Shanghai University of Traditional Chinese Medicine 1200 Cailun Road, Zhangjiang Hi‐Tech Park Shanghai 201210 People's Republic of China; Institute of Liver Diseases Shuguang Hospital affiliated to Shanghai University of Traditional Chinese Medicine 528 Zhangheng Road, Zhangjiang Hi‐Tech Park Shanghai 201210 People's Republic of China From the UT Microbiome Consortium, Center for Hypertension and Precision Medicine, Department of Physiology and Pharmacology, University of Toledo College of Medicine and Life Sciences, Toledo, OH. College of Chemistry and Molecular Engineering, Peking University, 100871 Beijing, China; College of Chemistry and Chemical Engineering, Chongqing University, 400044 Chongqing, China Department of Endocrinology (T.Y.), Jiangsu Diabetes Centre, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China Institute of Educational Statistic and Measurement Beijing Normal University Beijing 100875 People's Republic of China From the Departments of Medicine and Pharmacology, Vanderbilt University, Nashville, Tenn. Department of Neurobiology, Morehouse School of Medicine, Atlanta (R.Z., T.L., T.Y., Z.X.) State Key Laboratory of Urban Water Resource and Environment, School of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin 150090, China Institute of Cardiovascular Disease, Shuguang Hospital Affiliated with Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China. [email protected]. Beijing University of Chinese Medicine, Dongzhimen Hospital Key Laboratory of Chinese Internal Medicine, Ministry of Education & Beijing Beijing 100700 China; Beijing University of Chinese Medicine, Dongzhimen Hospital Laboratory for Integrated Traditional Chinese and Western Medical Research of Qi‐Blood Beijing 100700 China China University of Mining and Technology 1 College of Chemical Engineering, , Xuzhou 221008, China Institute of Horticulture Crops, Xinjiang Academy of Agricultural Sciences, Urumqi, China The Department of Urology Hebei General Hospital Shijiazhuang China Department of Otolaryngology-Head and Neck Surgery, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University School of Medicine , China; Ear Institute, Shanghai Jiao Tong University School of Medicine , China; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases , China College of Chemistry and Molecular Engineering; Nanjing Tech University; Nanjing 211816; P. R. China Ministry of Education Key Laboratory for Non-Equilibrium Synthesis and Modulation of Condensed Matter School of Physics Xi'an Jiaotong University Xi'an 710049 Shaanxi China Department of Computer Science and Engineering Arizona State University Tempe AZ USA Department of Endocrinology and Metabolism, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China. MOE Laboratory of Bioinorganic and Synthetic Chemistry/KLGHEI of Environment and Energy Chemistry, State Key Laboratory of Optoelectronic Materials and Technologies, School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, P.R. China Department of Otolaryngology—Head and Neck Surgery Xinhua Hospital Shanghai Jiaotong University School of Medicine Shanghai China Department of Joint and Sport Medicine, Tianjin Union Medical Center, PR China Department of Chinese Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, P.R. China Fuzhou University College of Chemistry and Chemical Engineering, Chongqing University, Chongqing 400044, People’s Republic of China State Key Laboratory of Biotherapy and Cancer Center, National Clinical Research Center for Geriatrics, West China Hospital of Sichuan University, Chengdu 610041, Sichuan, China Department of Neurosurgery and; Department of Clinical Innovative Medicine, Kyoto University Graduate School of Medicine, Kyoto, Japan Department of Pain Treatment Tangdu Hospital Fourth Military Medical University Xi'an Shaanxi 710032 P. R. China Department of Expanded Program on Immunization, Lu’an Municipal Center for Disease Control and Prevention , Lu'an, Anhui, China Department of Otolaryngology Head and Neck Surgery, the Second Xiangya Hospital of Central South University, Changsha, Hunan, PR China Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P.R. China Department of Chemistry and Chemical Biology, Baker Laboratory, Cornell University, Ithaca, New York 14853-1301, United States School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200241, P. R. China Department of Orthopaedics, Sun Yat-sen Memorial Hospital, Guangzhou, Guangdong Province, China Institute of Horticulture Crops, Xinjiang Academy of Agricultural Sciences (Key Laboratory of Genome Research and Genetic Improvement of Xinjiang Characteristic Fruits and Vegetables), Urumqi 830000, China; The State Key Laboratory of Genetic Improvement and Germplasm Innovation of Crop Resistance in Arid Desert Regions (Preparation), Urumqi 830000, China Department of Endocrinology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China Department of Otorhinolaryngology-Head and Neck Surgery, Xinhua Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, China; Ear Institute, Shanghai Jiaotong University, Shanghai, China; Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases, Shanghai, China Laboratory of Immunopharmacology Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai 201203 China; University of Chinese Academy of Sciences Beijing 10049 China Department of Orthopedic Oncology Guangdong Provincial People's Hospital Affiliated to South China University of Technology School of Medicine Guangzhou China State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China; Laboratory of Human Diseases and Immunotherapies, West China Hospital, Sichuan University, Chengdu 610041, China; Institute of Immunology and Inflammation, Frontiers Science Center for Disease-Related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China (mainland) Department of Joint and Sport Medicine, Tianjin Union Medical Center, PR China. Cardiovascular Research Institute, Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China The Department of Hepatological Surgery, Tongde Hospital of Zhejiang ProvinceZhejiang ProvinceP.R. China Institute of Horticulture Crops, Xinjiang Academy of Agricultural Sciences (Key Laboratory of Genome Research and Genetic Improvement of Xinjiang Characteristic Fruits and Vegetables), Urumqi 830091, China; The State Key Laboratory of Genetic Improvement and Germplasm Innovation of Crop Resistance in Arid Desert Regions (Preparation), Urumqi 830091, China Department of Intensive Care Unit, Wuhan Fourth Hospital, Puai Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China The Nephrology Department Beijing Haidian Hospital Beijing China Yuhang Center for Disease Control and Prevention, Hangzhou, Zhejiang, China; Jiangsu Chunlan Clean Energy Academy Co., Ltd; Taizhou 225300; China From the Department of Molecular Microbiology and Immunology (P.Y.L., S.L.S., A.E.B.P., N.S.L., V.K.C., N.N.A.M.v.d.D., M.P.S.P.), Oregon Health & Science University, Portland, OR; The Neuroscience Institute (T.Y., R.P.S.), Morehouse School of Medicine, Atlanta, GA. School of Pharmacy, Hainan Medical University, Haikou 571199, China Key Laboratory of Oil Gas Fine Chemicals, Ministry of Education Xinjiang Uyghur Autonomous Region, College of Chemistry and Chemical Engineering Xinjiang University Urumqi China; Xinjiang Product Quality Supervision and Inspection Research Institute Urumqi China Department of General Surgery First Affiliated Hospital of Jinzhou Medical University Jinzhou China College of Chinese Medicine and Life Science, Jiangxi University of Chinese Medicine, Nanchang 330004, China Department of Hepatobiliary Surgery The First Hospital of Shijiazhuang City Shijiazhuang China *State Key Laboratory of Biomembrane and Membrane Biotechnology, Institute of Zoology, Chinese Academy of Sciences, Beijing, China 100101; and State Key Laboratory of Pharmaceutical Biotechnology; School of Life Sciences; Nanjing University; Nanjing 210023; P. R. China Chinese Academy of Sciences; University of Chinese Academy of Sciences State Key Laboratory of Veterinary Biotechnology, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People's Republic of China Department of Endocrinology, the First Affiliated Hospital with Nanjing Medical University, Nanjing Medical University, China Department of Materials Science & Engineering City University of Hong Kong Hong Kong SAR China State Key Laboratory of Luminescent Materials and Devices, Guangdong Provincial Key Laboratory of Luminescence from Molecular Aggregates South China University of Technology 510640 Guangzhou P. R. China From the Oates Institute for Experimental Therapeutics and Division of Clinical Pharmacology, Departments of Medicine and Pharmacology (N.C., T.Y., I.H., B.C.K.); and Department of Pediatrics (P.J.K.), Vanderbilt University Medical Center, Nashville, Tenn; Cardiovascular Research Institute (T.H.), Washington Hospital Center, Washington DC; Laboratory for Mammalian Genes and Development (K.E., K.P.), National Institute of Child Health and Human Development/NIH, Bethesda, Md; Department of Medicine (B... State Key Laboratory of Radiation Medicine and Protection Jiangsu Key Laboratory of Neuropsychiatric Diseases, and College of Pharmaceutical Sciences Soochow University Suzhou 215123 China Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, China. State Key Laboratory of Structure Chemistry Fujian Institute of Research on the Structure of Matter Chinese Academy of Sciences Fuzhou Fujian 350002 P. R. China Center for Pulmonary Vascular Diseases, Fuwai Hospital, National Center for Cardiovascular Diseases Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Radiotherapy, PLA General Hospital, Beijing, 100853. Department of Neurobiology Neuroscience Institute, Morehouse School of Medicine Atlanta Georgia Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing, China Department of Pathology, Los Alamitos Medical Center 3751 Katella Avenue, Los Alamitos, CA 90720, USA. |
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