http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_9e065ec6331a195ecfd0ffc15d7569c9
Outgoing Links
Predicate | Object |
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family-name | Wang Bo Wang |
name | Bo Wang |
given-name | Bo |
organization-name | Shanxi Medical University, Taiyuan, Shanxi, China (mainland) From the Center for Reproductive Medicine, Shandong Provincial Hospital–Shandong University, the Key Laboratory of Reproductive Endocrinology of Ministry of Education, and the National Research Center for Assisted Reproductive Technology and Reproductive Genetics (Y. Shi, D.W., Z.W., M.S. H. Liu, J.L., L.Z., Z.-J.C.), and the Center for Reproductive Medicine, Qilu Hospital of Shandong University (X.D.), Jinan, the Center for Reproductive Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong... From the Molecular Cardiology Research Institute (H.-J.P., Y.Z., C.M., M.J.A., S.P.G., I.N., R.O.B., R.H.K., J.B.G.) and Cardiology Division (C.M., R.H.K., J.B.G.), Department of Medicine, Tufts Medical Center; and Center for Neuroscience Research (C.D.), Department of Neuroscience, Tufts University School of Medicine, Boston, Mass; Department of Neurosciences (C.M.W.), Medical University of South Carolina, Charleston; Department of Medicine (B.W., R.L.), Brigham and Women’s Hospital, Boston, Mass;... Department of Emergency, Hebei Provincial Hospital of Traditional Chinese Medicine , Shijiazhuang , Hebei , China Shaanxi Key Laboratory of Chemical Additives for Industry, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi’an 710021, China Department of Gastroenterological Surgery Laboratory of Surgical Oncology Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research Peking University People's Hospital Beijing China College of Veterinary Medicine Yangzhou University Yangzhou China Division of Nephrology, West China Hospital of Sichuan University, Chengdu, China. Bonita Stanton, Bo Wang, Xiaoming Li, Veronica Dinaj-Koci, and Sharon Marshall are with the Department of Pediatrics, Wayne State University School of Medicine, Detroit, MI. Lynette Deveaux and Sonja Lunn are with the Office of HIV/AIDS, Ministry of Health, Government of the Commonwealth of The Bahamas, Nassau, New Providence. Glenda Rolle is with the Ministry of Education, Science and Technology, Government of the Commonwealth of The Bahamas, Nassau. Nanika Braithwaite is with the Office of Health... Key Laboratory of Cluster Science, Ministry of Education of China, School of Chemistry, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing, 100081, P. R. China Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China Laboratory of Chemical Genomics, School of Chemical Biology and Biotechnology, Peking University Shenzhen Graduate School, Shenzhen University Town, Xili, Shenzhen 518055, China State Key Laboratory of Animal Nutrition College of Animal Science and Technology China Agricultural University Beijing China Department of Radiology, Gongli Hospital, Pudong New Area; Program on Regulation, Therapeutics, and Law (PORTAL), Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China Department of Bioengineering, Stanford University, Stanford, California 94305, United States University of Texas at Austin Department of Biomedical Engineering, , 1 University Station C0800, Austin, Texas 78712, USA State Key Laboratory of Electroanalytical Chemistry; Changchun Institute of Applied Chemistry; Chinese Academy of Sciences; Changchun 130022; China Department of Materials Science and Engineering, ‡Department of Physics, and §Department of Chemistry, University of Illinois, Urbana, Illinois 61801, United States Department of Ophthalmology, Renmin Hospital of Wuhan University, Wuhan, Hubei, China Department of Biological and Environmental Engineering Cornell University Ithaca NY 14853 USA State Key Laboratory of Metastable Materials Science and Technology, Key Laboratory of Applied Chemistry, Yanshan University, Qinhuangdao 066004, China Key Lab of Advanced Drug Preparation Technologies, Ministry of Education of China; State Key Laboratory of Esophageal Cancer Prevention & Treatment; Key Laboratory of Henan Province for Drug Quality and Evaluation; Institute of Drug Discovery and Development; School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou 450001, Henan, China School of Sports Medicine and Rehabilitation, Beijing Sport University, Beijing, China Key Laboratory of Medical Science and Laboratory Medicine of Jiangsu Province, School of Medicine, Jiangsu University, Zhenjiang 212013, Jiangsu, P.R. China Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, PR China; National University of Defense Technology; Hunan Key Laboratory of Ultra-Precision Machining Technology Department of Neurology The Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China Department of Pain Management Huadong Hospital Affiliated to Fudan University Shanghai China Department of Radiology, Gongli Hospital; Department of Paediatric Surgery, Tianjin Medical University General Hospital, Tianjin, China Laboratory of Lipid Biochemistry and Protein Interactions; Department of Cellular and Molecular Medicine; University of Leuven – KU Leuven; Leuven, Belgium Shanghai Children's Medical Center Shanghai Jiaotong University School of Medicine Shanghai China Institute of Sustainability for Chemicals, Energy and Environment, Agency for Science, Technology and Research, 1 Pesek Road, Jurong Island, Singapore 627833, Singapore Interdisciplinary Stem Cell Institute, University of Miami Miller School of Medicine, Miami, FL Department of Orthopaedics, Yuncheng Central Hospital, Shanxi University, Yuncheng, 044000, China Centre for Chemistry and Biotechnology; Deakin University; Geelong, Australia Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China Department of Osteology Second Clinical Medical College, Zhejiang Chinese Medical University Hangzhou China Department of Radiation Oncology and Winship Cancer Institute Emory University Atlanta GA 30322 USA Department of Dermatology, University of Michigan, Ann Arbor Department of Population and Quantitative Health Sciences, University of Massachusetts Chan Medical School , Worcester, MA , USA Division of Nephrology, Kidney Research Institute, West China Hospital, Sichuan University, Chengdu 610041, China Department of Chemistry, Tsinghua University, Beijing 100084, P. R. China Department of Oral and Craniomaxillofacial Surgery, Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China; National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai 200011, China; Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai 200011, China Surgical Department of Thyroid and Breast, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, P.R. China 2Meinian Institute of Health, Beijing, China; 3Peking University Health Science Center, Meinian Public Health Institute, Beijing, China Key Laboratory of Marine Bio-resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China BGI-Shenzhen, 518083, Shenzhen, China National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University Wuhan Hubei China Key Laboratory of Cluster Science, Ministry of Education of China, Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, School of Chemistry, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing 100081, P. R. China Dr. Ni and Ms. Hua are with the Department of Nursing, Dr. Wang and Dr. Yan are with the Department of Epidemiology, and Ms. Li is with the Department of Political Theories Teaching-Research, all at the Fourth Military Medical University, Xi’an, China. Ms. Ma is with the First Hospital, Lanzhou University, Gansu, China. Dr. Huang is with the Institute of Mental Health, Peking University, Beijing. Dr. Wallen is with the Department of Nursing, National Institutes of Health, Bethesda, Maryland. Ms. Lang is... Department of Applied Chemistry, China Agricultural University, 2 Yuanmingyuan West Road, Beijing 100193, China Jilin University, Jilin, China. Smart Materials Laboratory, Department of Applied Physics, Northwestern Polytechnical University, Xi’an 710129, China Institute of High Energy Physics, Chinese Academy of Sciences, Beijing 100049, China Xi 'an Haorui Genomics Technology Company Limited, Shanxi, China State Key Laboratory of Integrated Optoelectronics, Key Laboratory of Advanced Gas Sensors, Jilin Province, College of Electronic Science and Engineering, Jilin University, 2699 Qianjin Street, Changchun 130012, China The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, Guangdong, China Shanghai Ruijin Hospital, Shanghai Ruijin Hospital North, Affiliated to Shanghai Jiaotong University School of Medicine, International Laboratory in Hematology, Aging and Cancer, State Key Laboratory of Medical Genomics, Pôle Sino-Français de Recherche en Sciences du Vivant et Génomique, Shanghai, P.R. China; Shanghai Ruijin Hospital North, Shanghai Jiaotong University School of Medicine, Shanghai, P.R. China Department of Integrative Medicine, Jilin Provincial Cancer Hospital, Changchun 130012, China Key Laboratory of Aerospace Advanced Materials and Performance of Ministry of Education, School of Materials Science and Engineering, Beihang University, 100191, Beijing, China State Key Laboratory of Crystal Materials; Shandong University; Jinan 250100; China School of Graduate, Inner Mongolia Medical University, Hohhot, Inner Mongolia, China; Surgical Department of Thoracolumbar, the Second Affiliated Hospital of Inner Mongolia Medical University, Hohhot, Inner Mongolia, China Laboratory of Molecular Iron Metabolism College of Life Science Hebei Normal University Shijiazhuang China Department of Orthopedics and Trauma, Peking University People’s Hospital, Beijing, China Department of Traditional Chinese Medicine, Qilu Hospital, Shandong University, No. 107, Wen Hua Xi Road, Jinan, Shandong 250012, China Department of Chemistry, Chemical Theory Center, and Supercomputing Institute, University of Minnesota, 207 Pleasant St. SE, Minneapolis, Minnesota 55455-0431, United States Sorbonne Université CNRS Institut Parisien de Chimie Moléculaire (IPCM) UMR 8232 4, place Jussieu 75005 Paris France State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China; and School of Ecology and Environment, Anhui Normal University, Wuhu 241002, China School of Electronic and Information Engineering, University of Science and Technology Liaoning, Anshan, China Key Laboratory of Colloid and Interface Chemistry of Ministry of Education and School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, People’s Republic of China Department of Surgery, Northwell Health, Manhasset, New York Department of Obstetrics and Gynecology (B.W., K.K., Y.O., G.I., M.T., T.H., O.Y., Y.H., M.H., Y.T.), University of Tokyo, Tokyo 113-8655, Japan Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA School of Medicine, The Center for Infection and Immunity Study and Molecular Cancer Research Center, Key Laboratory for Efficacy and Safety Evaluation of Hematological Malignancy Targeted Medicine of Guangdong Provincial Drug Administration, Shenzhen Key Laboratory for Systems Medicine in Inflammatory Diseases Shenzhen Campus of Sun Yat‐sen University Guangdong Shenzhen China Department of Radiology, The First Affiliated Hospital of Nanchang University, Nanchang 330006, Jiangxi Province, China Department of Cardiology, Xi’an No.1 Hospital, Xi’an City, Shaanxi Province, China State Key Laboratory of Fine Chemicals, School of Chemical Engineering, Dalian University of Technology, Dalian 116012, People’s Republic of China Laboratory of Plant Physiology Wageningen University Droevendaalsesteeg 1 6708 PB Wageningen the Netherlands Department of Pathology and Forensic Medicine, Dalian Medical University, Dalian 116044, PR China Qingdao University Medical College Affiliated Yantai Yuhuangding Hospital, Yantai, Shandong, China Key Laboratory of Marine Materials and Related Technologies, Zhejiang Key Laboratory of Marine Materials and Protective Technologies, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China Department of Pathology, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang, China State Key Laboratory for Disaster Prevention & Mitigation of Explosion & Impact, Army Engineering University of PLA, Nanjing 210007, China Hair Transplantation Center Plastic Surgery Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China The Key Laboratory of Plant Molecular Physiology, Institute of Botany, Chinese Academy of Sciences, Beijing 100093, China; University of Chinese Academy of Sciences, Beijing 100049, China Department of Thoracic Surgery, Chinese PLA General Hospital, Beijing, P.R. China State Key Laboratory of Virology, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, People’s Republic of China; College of Animal Science and Technology Yangzhou University Yangzhou 225009 China; Key Laboratory for Animal Genetics, Breeding, Reproduction and Molecular Design of Jiangsu Province Yangzhou 225009 China; Joint International Research Laboratory of Agriculture and Agri‐Product Safety Yangzhou University Yangzhou 225009 China School of Environmental Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, 200240 Shanghai, China Department of Pathology, Xingtai People’s Hospital Affiliated to Hebei Medical University, Xingtai, Hebei, P.R. China. Musculoskeletal Oncology Center, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China Department of Pathology, The First Affiliated Hospital, Xinjiang Medical University , Urumqi , Xinjiang 830011 , P.R. China National Key Laboratory of Crop Genetic Improvement, College of Plant Science and Technology, Huazhong Agricultural University, Wuhan, China Department of Neurology, Children's Hospital, Chongqing University of Medical Science, Chongqing 400014, China. Department of Cardiovascular Surgery, Zhongnan Hospital of Wuhan University, School of Pharmaceutical Sciences Wuhan University Wuhan 430071 China; Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE), School of Pharmaceutical Sciences Wuhan University Wuhan 430071 China National Key Laboratory of Science and Technology on Micro/Nano Fabrication, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Department of Micro/Nano Electronics, School of Electronic Information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China College of Food Science Northeast Agricultural University Harbin Heilongjiang China for the NOVA Trial Investigators Collaborative Innovation Center of New Drug Research and Safety Evaluation, Henan Province; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education; Key Laboratory of Henan Province for Drug Quality and Evaluation; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou 450001, P. R. China Center for Composite Materials and Structure Harbin Institute of Technology Harbin 150001 China Institute of Drug Synthesis and Pharmaceutical Process, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China Department of Gynaecology, Cancer Biology Research Center, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei 430030, P.R. China NMPA Key Laboratory for Safety Evaluation of Cosmetics Guangdong Provincial Key Laboratory of Tropical Disease Research School of Public Health Southern Medical University Guangzhou 510515 China School of Materials Engineering, Shanghai University of Engineering Science, Shanghai 201620, China Department of Chemistry, Institute of Molecular Plus Tianjin Key Laboratory of Molecular Optoelectronic Science Tianjin University Tianjin 300072 China Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan 430030, China; Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education, Wuhan 430030, China College of Plant Protection, Jilin Agricultural University, Changchun, Jilin, China Department of Kidney Disease and Blood Purification, Institute of Urology & Key Laboratory of Tianjin, The Second Hospital of Tianjin Medical University, Tianjin 300211, China Department of Pharmaceutics, School of Pharmacy China Pharmaceutical University Nanjing Jiangsu People's Republic of China Institute of Clean Coal Technology, East China University of Science and Technology, Shanghai 200237, PR China Guangdong Women and Children Hospital and Health Institute Guangzhou Guangdong China Key Laboratory of Applied Marine Biotechnology of Department of Education, Key Laboratory of Marine Biotechnology of Zhejiang Province, School of Marine Sciences Ningbo University Ningbo China School of Chemical Engineering and Light Industry Guangdong University of Technology Guangzhou 510006 P. R. China Key Laboratory of Resource Biology and Biotechnology in Western China, Ministry of Education and Provincial Key Laboratory of Biotechnology, College of Life Sciences, Northwest University, Xi’an 710069, China Third People’s Hospital, China Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry University No.35 Tsinghua East Road Beijing 100083 PR China Department of Materials Science and Engineering Pennsylvania State University 221 Steidle Building University Park PA 16802 USA Institut de Génétique et de Biologie Moléculaire et Cellulaire (Centre National de la Recherche Scientifique/Institut National de la Santé et de la Recherche Médicale/Université Louis Pasteur) 1, rue Laurent Fries, 67404 Illkirch, C.U. de Strasbourg, France; and Institut de Recherche sur le Cancer, Chemin des Boveresses 155, CH-1066 Epalinges, Switzerland Department of Science and Education, Qinghai Provincial People’s Hospital, Xining, 810007, Qinghai Province, China Department of Applied Chemistry China Agricultural University Beijing 100193 People's Republic of China From the Centre for Vascular Research, University of New South Wales, Sydney, Australia (B.W., J.C., F.S.S., M.M.K., B.H.C., and L.M.K.); Qiqihar Medical University, Qiqihar, People’s Republic of China (B.W.); and the Cancer Research Centre and Prince of Wales Clinical School, Faculty of Medicine, University of New South Wales, Sydney, Australia (M.J. and J.E.P.). Departments of aMaterials Science and Engineering, Key Laboratory of Colloid and Interface Chemistry, Ministry of Education, and School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, People’s Republic of China Beijing Advanced Innovation Center for Soft Matter Science and Engineering & State Key Laboratory of Organic-Inorganic Composites Beijing University of Chemical Technology Beijing 100029 P. R. China MOE Key Laboratory of Macromolecular Synthesis and Functionalization Department of Polymer Science and Engineering Key Laboratory of Adsorption and Separation Materials and Technologies of Zhejiang Province Zhejiang University 38 Zheda Road Hangzhou 310027 China State Key Laboratory of Palaeobiology and Stratigraphy, Nanjing Institute of Geology and Palaeontology and Center for Excellence in Life and Paleoenvironment, Chinese Academy of Sciences, 39 East Beijing Road, Nanjing 210008, People's Republic of China National‐Local Joint Engineering Laboratory of Breeding and Cultivation of Edible and Medicinal Fungi, Mushroom Research Center Soil and Fertilizer Institute, Sichuan Academy of Agricultural Sciences Chengdu China; Scientific Observing and Experimental Station of Agro‐Microbial Resource and Utilization in Southwest China Ministry of Agriculture Chengdu China Department of Biomedical Engineering, University of Texas at Austin, Austin, Texas 78712, Departments of Biomedical Engineering and Imaging Physics, University of Texas M.D. Anderson Cancer Center, Houston, Texas 77030 USA Department of Thoracic Surgery, Chinese PLA General Hospital, Beijing Joint International Research Laboratory of Agriculture and Agri‐Product Safety Yangzhou University Yangzhou China; College of Veterinary Medicine Yangzhou University Yangzhou China Wayne State University School of Medicine, Detroit, MI, USA Department of Applied Chemistry; China Agricultural University; Beijing 100193; China State Key Laboratory of Silicon Materials School of Materials Science and Engineering Zhejiang University Hangzhou 310030 China Key Laboratory for Precision and Non-Traditional Machining Technology of Ministry of Education, Dalian University of Technology, Dalian 116024, China; Key Laboratory of Marine Materials and Related Technologies, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China Washington Center for Muscle Biology, Washington State University, Pullman, Washington. State Key Laboratory of Organic Electronics and Information Displays, Institute of Advanced Materials, Nanjing University of Posts & Telecommunications, Nanjing 210023, China Department of Laboratory Medicine, the Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, PR China Department of Surgery, Ajou University School of Medicine, Suwon, Korea College of Computer Science and Electronic Engineering, Hunan University , Changsha 410083, China College of Bioresources Chemical & Materials Engineering, Shaanxi University of Science and Technology, Xi′an 710021, China Department of Orthopedics, Changzheng Hospital, Shanghai, China First Institute of Oceanography SOA, Qingdao, PR China and State Key Laboratory for Turbulence and Complex Systems, Department of Advanced Manufacturing and Robotics, College of Engineering, Peking University, Beijing 100871, China Department of Neurosurgery, Binzhou Medical University Hospital, Binzhou All authors: Department of Plant Pathology, College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China/Key Laboratory of Integrated Management of Crop Diseases and Pests (Nanjing Agricultural University), Ministry of Education, P.R. China; and sixth author: Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, P.R. China. State Key Laboratory of Chemical Resource Engineering, Beijing University of Chemical Technology, P.O. Box 98, Beijing 100029, China Central South University School of Materials Science and Engineering, Pennsylvania State University, State College, Pennsylvania 16802, United States China National GeneBank, BGI Shenzhen, Shenzhen, China Institute of Atomic and Molecular Physics; Jilin University; Changchun; China; Jilin Provincial Key Laboratory of Applied Atomic and Molecular Spectroscopy (Jilin University) Qingdao Key Laboratory of Specialty Plant Germplasm Innovation and Utilization in Saline Soils of Coastal Beach, Qingdao Agricultural University, Qingdao 266109, P. R. China; Key Laboratory of National Forestry and Grassland Administration on Grassland Resources and Ecology in the Yellow River Delta, College of Grassland Science, Qingdao Agricultural University, Qingdao 266109, P. R. China Collaborative Innovation Center of New Drug Research and Safety Evaluation; Key Laboratory of Technology of Drug Preparation; Ministry of Education of China; School of Pharmaceutical Sciences; Zhengzhou University College of Integrative Medicine, The National & Local Joint Engineering Research Center for Drug Development of Neurodegenerative Disease, College of Pharmacy, Dalian Medical University, Dalian 116044, China Centre for Advanced Optoelectronic Functional Materials Research and Key Laboratory for UV Light-Emitting Materials and Technology of Ministry of Education, Northeast Normal University, Changchun 130024, China; State Key Laboratory of Metastable Materials Science & Technology and Key Laboratory for Microstructural Material Physics of Hebei Province, School of Science, Yanshan University, Qinhuangdao 066004, China Department of Orthopedics, Changzheng Hospital of Naval Military Medical University, Shanghai, China School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China Research Center for Translational Medicine, Shanghai East Hospital Tongji University School of Medicine Shanghai China State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, P. R. China Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Shenyang 110000, Liaoning, People’s Republic of China Wuhan National Laboratory for Optoelectronics, School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430074, Hubei People’s Republic of China MOA Key Laboratory of Crop Ecophysiology and Farming System in the Middle Reaches of the Yangtze River College of Plant Science and Technology, Huazhong Agricultural University Wuhan Hubei Province China University of Shanghai for Science and Technology, 516 Jungong Road, Shanghai 200093, China Department of Applied Chemistry, China Agricultural University, Beijing 100193, P. R. China Department of Anesthesiology, Tongren Hospital of Wuhan University (Wuhan Third Hospital), Wuhan, Hubei 430060, China Key Laboratory of Environmental Biotechnology, Research Center for Eco-Environmental Sciences, Chinese Academy of Sciences, Beijing, China BioTools, Inc., 17546 Bee Line Highway, Jupiter, Florida 33458, United States Department of Natural Product Chemistry, Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences, Shandong University, 44 West Wenhua Road, Jinan 250012, People’s Republic of China Nankai University China National GeneBank BGI‐Shenzhen Shenzhen China Pathway Research Inc., Lethbridge, AB T1K7X8, Canada; University of Lethbridge, Lethbridge, AB T1K3M4, Canada Department of Interventional Neuroradiology (X.T., B.J., X.Z., X.H., G.L., N.M., F.G., L.S., X.S., L.L., Y.D., X.L., B.W., G.M., Z.M., D.M.), Beijing Tiantan Hospital, Capital Medical University, China. BGI-Shenzhen, Shenzhen 518083, China School of Chemical Engineering, Sichuan University, Chengdu 610065, China Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China Beijing Institute of Spacecraft System Engineering; Beijing 100094; China First Institute of Oceanography SOA, Qingdao, PR China MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical Engineering Harbin Institute of Technology Harbin 150001 China Key Laboratory of Cluster Science, Ministry of Education of China, School of Chemistry, Beijing Institute of Technology, 100081 Beijing, P. R China Department of Population and Quantitative Health Sciences, University of Massachusetts Medical School, 368 Plantation Street, Worcester, Massachusetts, USA Departments of Neurosurgery, Department of Anesthesiology, Shandong Provincial Hospital Affiliated to Shandong University Jinan 250021, China. Agios Pharmaceuticals, Inc., Cambridge, Massachusetts 02139, United States School of electrical and computer engineering, Jilin jianzhu university, Changchun 130118, China Department of ophthalmology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China School of Chemistry, Sun Yat-sen University, Guangzhou 510275, China 2Antibody Discovery and Protein Engineering, R&D, AstraZeneca. First, second, fourth, and ninth authors: Institute of Plant Protection, Jiangsu Academy of Agricultural Science, Nanjing 210014, China; third, fifth, sixth, seventh, and ninth authors: College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China/Key Laboratory of Integrated Management of Crop Diseases and Pests (Nanjing Agricultural University), Ministry of Education, China; and eighth author: Department of Biological Sciences, University of South Carolina, Columbia. Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease Shanghai China Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, 6 Xuefu Road, Weiyang District, Xi’an, Shaanxi 710021, China Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510100, China; Guangdong Provincial Key Laboratory of Pathogenesis, Targeted Prevention and Treatment of Heart Disease, Guangzhou 510640, China School of computer and control engineering Qiqihar university Qiqihar 161006 China From the Departments of Pharmaceutical SciencesHematology-Oncology, and Biostatistics and Epidemiology, St. Jude Children’s Research Hospital, and Colleges of Pharmacy and Medicine, University of Tennessee, Memphis, TN. Key Laboratory of Industrial Ecology and Environmental Engineering (Ministry of Education, MOE), School of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China Key Laboratory for Precision and Non-Traditional Machining Technology of Ministry of Education; Dalian University of Technology; Dalian 116024; China; Key Laboratory of Marine Materials and Related Technologies Wuhan National Laboratory for Optoelectronics, and School of Optical and Electronic Information, Huazhong University of Science and Technology, Wuhan 430074, China School of Materials Science and Engineering, University of Jinan, Jinan 250022, P. R. China Henan Institute of Science and Technology, College of Animal Science and Veterinary Medicine, Xinxiang 453003, China Laboratory of Immunology and Nanomedicine, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, Shenzhen 518055, China Wayne State University, Detroit, MI, USA From the Departments of Urology, Pharmacology and Toxicology, and Psychiatry and Mental Health, Medical College of Wisconsin, Milwaukee, Wisconsin; Cardiovascular Discovery, Pharmaceutical Products Division, Abbott Laboratories, Abbott Park, Illinois Key Laboratory of Marine Drugs (Ocean University of China), Chinese Ministry of Education, and School of Medicine and Pharmacy, Ocean University of China, 5 Yushan Road, Qingdao 266003, China Department of Anesthesiology, West China Hospital of Sichuan University, Chengdu, China Shanghai Key Laboratory of Green Chemistry and Chemical Process School of Chemistry and Molecular Engineering East China Normal University North Zhongshan R. 3663 Shanghai 200062 China State Key Laboratory of Animal Nutrition, Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, China Agricultural University, Beijing 100091, China Institute of Micro/Nano Materials and Devices Ningbo University of Technology Ningbo 315016 China Department of Chemistry, Tulane University, 6400 Freret Street, New Orleans, Louisiana 70118-5638, United States School of Environmental and Municipal Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China Xiangtan University Contribution from the School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459, Institute of Materials Research and Engineering, Singapore 117602, and School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798 for the ED-SAFE 2 Investigators Immunology and Reproduction Biology Laboratory & State Key Laboratory of Analytical Chemistry for Life Science, Medical School, Nanjing University, Nanjing, Jiangsu 210093, China; Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing, Jiangsu 210093, China State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences China Agricultural University Beijing 100193 China Department of Neurology, University of Michigan, Ann Arbor, MI, USA College of Life Science, Northeast Agricultural University, Harbin, P.R. China, State Key Laboratory of Mycology, Institute of Microbiology, Chinese Academy of Sciences, Beijing, P. R. China Binzhou Medical University, Yantai, Shandong 264003, China School of Safety Science and Engineering, Henan Polytechnic University, Jiaozuo, Henan 454003, China School of Artificial Intelligence and Automation Huazhong University of Science and Technology Wuhan China Department of Materials Science and Engineering, Pennsylvania State University, University Park, Pennsylvania 16802, United States Department of Cardiology First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China; Key Laboratory of Cardiac Injury and Repair of Henan Province Zhengzhou Henan China School of Chemistry & Chemical Engineering; Sun Yat-sen University; Guangzhou, China Key Laboratory of Applied Surface and Colloid Chemistry, Ministry of Education, Institute of Energy Chemistry, School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an 710062, People's Republic of China Department of Physical Diagnostics, West Hospital District of Qingdao Multicipal Hospital, Qingdao 266002, China Institute of Functional Nano and Soft Materials (FUNSOM); Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices; Soochow University; Suzhou; China Department of Gastroenterological Surgery, Peking University People’s Hospital, Beijing, China; Laboratory of Surgical Oncology, Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research, Peking University People’s Hospital, Beijing, China *Microbiology and Immunology, Department of Epidemiology, Fourth Military Medical University, Xi'an 710032, China. CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, P.R. China Department of Molecular Pathology, The Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou, China.; Henan Key Laboratory of Molecular Pathology, Zhengzhou, China. Xiangya School of Pharmaceutical Sciences, Central South University, Changsha, Hunan 410000, China Hebei Key Laboratory of Flexible Functional Materials School of Materials Science and Engineering Hebei University of Science and Technology Hebei 050000 China State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou, 730000, China State Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergistic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts and Telecommunications, 9 Wenyuan Road, Nanjing 210023, China Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, No. 119 South 4th Ring West Road, Fengtai District, People’s Republic of China Department of Neurosurgery, Tianjin Huanhu Hospital, Tianjin 300050, P.R. China Department of Chest Surgery, Nanjing Chest Hospital, Nanjing, Jiangsu 210029, P.R. China Academy of Military Medical Sciences 1 Institute of Transfusion Medicine, , No. 27 Taiping Road, HaiDian, Beijing 100850, China Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China Key Laboratory of Cluster Science, Ministry of Education of China, School of Chemistry, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing 100081, P. R. China Department of Interventional Neurology, Beijing Tiantan Hospital, Capital Medical University, China; China National Clinical Research Center for Neurological Diseases, China; Center of Stroke, Beijing Institute for Brain Disorders, China; Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, China Department of Paediatric Surgery, Tianjin Medical University General Hospital, Tianjin, P.R.China Shanghai Key Laboratory of Green Chemistry and Chemical Process; School of Chemistry and Molecular Engineering; East China Normal University; Shanghai 200062; China State Key Laboratory of Inorganic Synthesis and Preparative Chemistry, College of Chemistry, Jilin University, Changchun130012, China Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA. Division of Medical Biochemistry, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa Shanghai Key Laboratory of Plant Molecular Sciences, College of Life Sciences, Shanghai Normal University, Shanghai 200234, China Department of Food Science & Engineering School of Agriculture and Biology Shanghai Jiao Tong University Shanghai China National Key Laboratory of Science and Technology on Micro/Nano Fabrication, Key Laboratory for Thin Film and Microfabrication of Ministry of Education, Department of Micro/Nano Electronics, School of Electronic information and Electrical Engineering, Shanghai Jiao Tong University, Shanghai 200240, China Advaccine Biopharmaceuticals Suzhou Co., Ltd., Suzhou 215000, China Cancer Research Laboratories, School of Pharmaceutical Sciences, University of Nottingham, Nottingham, NG7 2RD, U.K., and Tumor Biology Center, University of Freiburg, Breisacherstrasse 117, D-79106, Freiburg, Germany for the CORONA Collaboration Shaanxi Key Laboratory of Chemical Additives for Industry, College of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi'an 710021, China Chinese Stomatological Association Beijing China University of Massachusetts Medical School Worcester MA CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences Beijing China; College of Life Sciences University of Chinese Academy of Sciences Beijing China Comprehensive Transplant Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois.; Department of Surgery, Northwestern University Feinberg School of Medicine, Chicago, Illinois. School of Food and Biological Engineering, Jiangsu University, Zhenjiang, PR China The First Affiliated Hospital, Institute of Translational Medicine, School of Public Health, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, School of Medicine, Zhejiang University, Hangzhou 310058, China College of Science, Northwest A&F University, Yangling, Shaanxi 712100, China Department of Animal Sciences Washington State University Pullman WA 99164 USA Department of Critical Care Medicine West China Hospital Sichuan University Chengdu China National Clinical Research Center for Obstetrical and Gynecological Diseases, Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China; Key Laboratory of Cancer Invasion and Metastasis, Ministry of Education, Wuhan 430030, China Institute of Biochemistry and Molecular Biology; School of Life Sciences; Lanzhou University; Lanzhou 730000; China Xidian University School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, People’s Republic of China College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan, 250014, P. R. China Department of Chemistry University of Copenhagen Universitetsparken 5 2100 Copenhagen Denmark College of Chemical and Biological Engineering, Shandong University of Science and Technology, J2-424, 579 Qianwangang Road, Qingdao 266590, P. R. China Department of Hepatobiliary Surgery and Institute of Advanced Surgical Technology and Engineering The First Affiliated Hospital of Xi’an Jiaotong University 277 West Yanta Road 710061 Xi’an Shaanxi Province People’s Republic of China; Shaanxi Provincial Regenerative Medicine and Surgical Engineering Research Center 710061 Xi’an Shaanxi Province People’s Republic of China Department of Joint Surgery, Xi'an Hong Hui Hospital Xi'an Jiaotong University Health Science Center Xi'an Shaanxi China Department of Biomedical Engineering School of Basic Medical Science Central South University Changsha Hunan 410083 China College of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450052, People’s Republic of China School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459, and School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798 Department of Urology, Suzhou Kowloon Hospital Shanghai Jiao Tong University School of Medicine, Suzhou 215021, Jiangsu, China Research Center for Photovoltaics, Shanghai Institute of Space Power-Sources, Shanghai 200245, China Wuhan National Laboratory for Optoelectronics, Huazhong University of Science and Technology, Wuhan 430074, China Hair Transplantation Center Plastic Surgery Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China Department of Dermatology University of Michigan Ann Arbor Michigan USA Department of Pediatric Surgery, Huai'an Women and Children's Hospital, Jiang Su, Huai'an, China State Key Laboratory of Plant Physiology and Biochemistry College of Biological Sciences China Agricultural University Beijing 100193 China Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon‐Based Functional Materials & Devices Soochow University 199 Ren'ai Road Jiangsu Suzhou 215123 P. R. China Key Laboratory of Drug Quality Control and Pharmacovigilance Ministry of Education China Pharmaceutical University Nanjing 210009 China Department of Vascular and Thyroid Surgery, Fujian Medical University Affiliated Union Hospital, Fuzhou, China. State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, P. R. China National Key Laboratory for Remanufacturing, Army Academy of Armored Forces, Beijing 100072, P. R. China State Key Laboratory of Crystal Materials; Crystal Institute; Shandong University; Jinan 250100; China From the School of Life Sciences and Engineering, Foshan University, Foshan, Guangdong Province (Z.-D.W., Z.-T.Y., H.-J.Z., S.-J.H., J.C., F.-Q.H., Q.L.), the Military Veterinary Institute, Academy of Military Medical Sciences, Changchun, Jilin Province (Z.-D.W., L.L., S.-C.W., Q.L.), MOA Key Laboratory of Animal Virology and Department of Veterinary Medicine, Zhejiang University, Hangzhou, Zhejiang Province (Z.-D.W., Y.Y., J.H., Y.-L.J., J.-Y.Z.), the Second Affiliated Hospital of Inner Mongolia... Changchun University of Chinese Medicine, Changchun, Jilin 130117, China State Key Laboratory of Heavy Oil Processing; China University of Petroleum; Beijing; P. R. China National Engineering Laboratory for Advanced Municipal Wastewater Treatment and Reuse Technology, Engineering Research Center of Beijing, Beijing University of Technology, Beijing 100124, P. R. China Life Sciences Institute, Department of Medicinal Chemistry, Department of Chemistry, Department of Biological Chemistry, and Department of Microbiology & Immunology, University of Michigan, Ann Arbor, Michigan 48109, Department of Chemistry, University of Pittsburgh, Pittsburgh, Pennsylvania 15260, and Scripps Institution of Oceanography, University of California at San Diego, La Jolla, California 92093 Department of Ultrasound, Xijing Hospital, The Fourth Military Medical University, Xi’an, Shaanxi 710032, China. School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou, 510006, China Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou, Jiangsu 215123, China School of Environmental Science and Engineering, Shanghai Jiao Tong University, 800 Dongchuan Road, Shanghai 200240, China Institute of Functional Nano & Soft Materials (FUNSOM); Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices; Soochow University; Suzhou; P. R. China Key Laboratory for Advanced Materials and Institute of Fine Chemicals Shanghai Key Laboratory of Functional Materials Chemistry School of Chemistry and Molecular Engineering East China University of Science & Technology Shanghai 200237 P.R. China The Key Laboratory of Plant Molecular Physiology, Institute of Botany, Chinese Academy of Sciences , Beijing 100093, China; University of the Chinese Academy of Sciences , Beijing 100049, China State Key Laboratory of Animal Nutrition, College of Animal Science and Technology China Agricultural University Beijing P. R. China Institute of Liver Studies King's College Hospital London UK Department of Cell Biology, School of Medicine Nankai University Tianjin China Washington Centre for Muscle Biology and Department of Animal Sciences Washington State University Pullman WA USA State Key Laboratory of Robotics; Shenyang Institute of Automation; Chinese Academy of Sciences; Shenyang; P. R. China School of Public Health, Fudan University, Shanghai 200032, China. Department of Chemistry and Chemical Biology, Indiana University Purdue University Indianapolis (IUPUI), Indianapolis, Indiana 46202, United States Key Laboratory of Colloid and Interface Chemistry of Ministry of Education and School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, P. R. China State Key Laboratory of Virology Department Gynecology Cancer Biology Research Center Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei 430030 P. R. China College of Food Science and Nutritional Engineering, China Agricultural University, Beijing 100083, China Engineering Research Center of Forestry Biomass Materials and Bioenergy; Beijing Key Laboratory of Lignocellulosic Chemistry; College of Materials Science and Technology; Beijing Forestry University; Beijing 100083 School of Chemistry and Chemical Engineering; Jiangsu University; Zhenjiang 212013; P.R. China Department of Radiology, West China Hospital, Sichuan University, Chengdu 610041, China Department of Molecular and Cellular Biochemistry; Ohio State University; Columbus OH; Molecular, Cellular and Developmental Biology Program; Ohio State University; Columbus OH Department of Clinical Laboratory The Second Affiliated Hospital of Chongqing Medical University Chongqing China Department of Chemistry, Tsinghua University, Beijing 100084, PR China Department of Orthopedics, The Second Affiliated Hospital of Harbin Medical University, Harbin, China Institute of Beneficial Insects, Plant Protection College, Fujian Agriculture and Forestry University, Fuzhou, China; State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Fuzhou, China; Key Laboratory of Biopesticide and Chemical Biology, Ministry of Education, Fuzhou, China School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, China Key Laboratory of Environmental Biotechnology; Research Centre for Eco-Environmental Sciences; Chinese Academy of Sciences; Beijing 100085; China College of Chemistry and Chemical Engineering, Shaanxi Key Laboratory of Chemical Additives for Industry, Shaanxi University of Science and Technology, Xi’an 710021, China California Nanosystems Institute, University of California–Los Angeles (UCLA)–Department of Energy (DOE) Institute of Genomics and Proteomics, Department of Chemistry and Biochemistry, UCLA, 607 Charles E. Young Drive East, Los Angeles, CA 90095, USA. The Key Laboratory of Advanced Functional Materials of China Education Ministry, Beijing Polytechnic University, 100022, Beijing, People's Republic of China Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, 199 Ren’ai Road, Suzhou 215123, Jiangsu, China Joint Surgery and Sports Medicine Department, Shanghai Changzheng Hospital Second Military Medical University Shanghai China Department of Neurology, Second Affiliated Hospital, School of Medicine Zhejiang University Hangzhou China Institute of Immunology and Molecular Medicine Jining Medical University Shandong China Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, Shandong University School of Medicine, Jinan, Shandong, 250012, P.R. China Wuhan National Laboratory for Optoelectronics (WNLO) and School of Optical and Electronic Information Huazhong University of Science and Technology 1037 Luoyu Road Wuhan 430074 P. R. China Department of Gastroenterology, The 980th Hospital of the People's Liberation Army Joint Service (Bethune International Peace Hospital), Shijiazhuang, Hebei 050082, P.R. China School of Pharmaceutical Sciences & Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou University, Zhengzhou 450001, China Aquatic Ecology and Water Quality Management Group, Wageningen University, P.O. Box 47, 6700 AA Wageningen, The Netherlands National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University Wuhan 430070 China Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, China State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin,P. R. China Department of Cardiology the First Affiliated Hospital of Zhengzhou University Zhengzhou Henan Province China Department of Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, China Department of Oncology, The Fourth Medical Center of Chinese People's Liberation Army General Hospital, Beijing 100048, P.R. China School of Biotechnology and Food Engineering, Hefei University of Technology, Hefei 230009, China. From the Department of Blood Products and Substitutes, Institute of Transfusion Medicine, Academy of Military Medical Sciences, Beijing, People’s Republic of China. Department of Traditional Chinese Medicine, Qilu Hospital, Cheeloo College of Medicine, Shandong University, Jinan, China. Key Laboratory of Cluster Science Ministry of Education of China School of Chemistry Beijing Institute of Technology 5 South Zhongguancun Street Beijing 100081 P.R. China University of Toronto, ICES Rm G‐106, 2075 Bayview Ave. Toronto ON M4G2E1 Canada Department of Chemistry, Chemical Theory Center, and Supercomputing Institute and ‡Department of Chemistry, University of Minnesota, 207 Pleasant Street S.E., Minneapolis, Minnesota 55455-0431, United States School of Materials Science and Engineering; Tianjin Chengjian University; Tianjin; P. R. China From the Laboratory of Vascular and Cancer Biology, Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, the First Affiliated Hospital, Soochow University, Suzhou, China (B.S., Z.S., L.Z., F.Z., T.L., M.C., H.J., Y.W., Y.H.); Laboratory of Vascular and Cancer Biology, MOE Key Laboratory for Model Animal and Disease Study, Model Animal Research Institute, Nanjing University, Nanjing, China (B.S., B.W., L.Z., F.Z., T.L., J.Z., W.S.); Department of Vascular Surgery, Nanjing Drum Tower... Key Laboratory of Animal Biotechnology of Ministry of Agriculture Northwest A & F University Yangling Shaanxi China; College of Veterinary Medicine Northwest A & F University Yangling Shaanxi China From the Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Mass. Department of Population and Quantitative Health Sciences University of Massachusetts Medical School Worcester MA USA Beijing Institute of Pharmacology and Toxicology Beijing China China National GeneBank, Beijing Genomics Institute (BGI)–Shenzhen, Shenzhen, 518083, China. Liaoning Engineering Research Center for Treatment and Recycling of Industrially Discharged Heavy Metals, Shenyang University of Chemical Technology, Shenyang 110142, China School of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou 510006, China Department of Materials Science and Engineering, Penn State University, University Park, Pennsylvania16802, United States School of Environmental and Chemical Engineering, Hebei Key Laboratory of Appied Chemistry, Yanshan University, Qinhuangdao 066004, China Department of Materials Science and Engineering Hebei University of Science and Technology Hebei 050018 China State Key Joint Laboratory of ESPC; School of Environment; Tsinghua University; Beijing 100084; China Key Laboratory of Advanced Pharmaceutical Technology, Ministry of Education of China, Co-innovation Center of Henan Province for New Drug R & D and Preclinical Safety, and School of Pharmaceutical Sciences, Zhengzhou University, 100 Kexue Avenue, Zhengzhou, Henan 450001, China Guangdong Provincial Key Laboratory of New Drug Design and Evaluation, School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, People’s Republic of China Department of Oral Radiology, School of Stomatology, China Medical University, Shenyang 110002, P. R. China Department of Hepatobiliary Surgery and Institute of Advanced Surgical Technology and Engineering, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province, China; National-Local Joint Engineering Research Center for Precision Surgery & Regenerative Medicine, Xi’an Jiaotong University, Xi’an, Shaanxi Province, China College of Food Science and Nutritional Engineering China Agricultural University Beijing China 1Department of Microbiology and Immunology Department of Orthopaedics, Taihe Hospital, Hubei University of Medicine, Shiyan, Hubei, P.R. China Beijing National Laboratory of Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China Educational Ministry Key Laboratory of Resource Biology and Biotechnology in Western China, College of Life Science, Northwest University, Xi’an 710069, China Department of Chemistry and Chemical Engineering, Florida Institute of Technology, Melbourne, FL, USA Department of Molecular and Cell Biology, School of Life Science and Technology Tongji University Shanghai 200092 China; College of Life and Environmental Sciences Shanghai Normal University Shanghai 200234 China Division of Hematology and Medical Oncology Icahn School of Medicine at Mount Sinai Tisch Cancer Institute New York NY USA Department of Pharmaceutics, School of Pharmacy, China Pharmaceutical University, Nanjing, PR China Xinjiang Laboratory of Special Environmental Microbiology, Urumqi 830091, Xinjiang, PR China; Institute of Applied Microbiology, Xinjiang Academy of Agricultural Sciences, Urumqi 830091, Xinjiang, PR China Affiliated Hospital of Changchun University of Chinese Medicine, 1478 Gongnong Road, Changchun City, Jilin Province, China State Key Laboratory of Crop Genetics and Germplasm Enhancement College of Horticulture Nanjing Agricultural University Nanjing China State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, PR China CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, People's Republic of China Institute of Animal Nutrition, Northeast Agricultural University, Harbin 150030, China Department of General Surgery, Guizhou Provincial People's Hospital, Guiyang Medical University, Guiyang, Guizhou 550002, P.R. China State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, P.R. China Fujian Key Laboratory of Innate Immune Biology, Biomedical Research Center of South China, Key Laboratory of OptoElectronic Science and Technology for Medicine of Ministry of Education & College of Life Sciences, Fujian Normal University State Key Laboratory of Metastable Materials Science & Technology and Key Laboratory for Microstructural Material Physics of Hebei Province, School of Science, Yanshan University, Qinhuangdao 066004, China; Centre for Advanced Optoelectronic Functional Materials Research and Key Laboratory for UV Light-Emitting Materials and Technology of Ministry of Education, Northeast Normal University, Changchun 130024, China Department of Ophthalmology, University of Pittsburgh Medical Center Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States 2Department of B Musculoskeletal Oncology Center, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China. School of Environmental Science and Engineering; Shanghai Jiao Tong University; Shanghai 200240; China Department of Hematology, First Hospital Affiliated to Zhejiang University of Traditional Chinese Medicine, Hangzhou, Zhejiang 310006, P.R. China State Key Laboratory of Integrated Management of Pest Insects and Rodents, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China Division of Viral Gastroenteritis, Hepatitis Pathogens and Enteroviruses, Department of Infectious Diseases, Robert Koch Institute, Berlin, Germany Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina School of Pharmacy , Xi’an Jiaotong University , 710061 Xi’an , Shaanxi China School of Chemistry and Chemical-Engineering, Northwestern Polytechnical University, Xi’an, 710129 Shaanxi, China; School of Aeronautics, Northwestern Polytechnical University, Xi’an, 710072 Shaanxi, China College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, PR China Department of Chemistry, Chemical Theory Center, and Supercomputing Institute, University of Minnesota, 207 Pleasant Street S.E., Minneapolis, Minnesota 55455-0431, United States Institute of Animal Nutrition, Northeast Agricultural University, Harbin, Heilongjiang, China State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, China Department of Neurology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China Department of Computer Science Stanford University Stanford CA USA State Key Laboratory of Applied Organic Chemistry, College of Chemistry and Chemical Engineering, Lanzhou University, Lanzhou 730000, P. R. China; Gansu Engineering Research Center of Medical Collagen, Lanzhou 730000, China Department of Physics and Astronomy, Clemson University, Clemson, South Carolina 29634, United States Tisch Cancer Institute, Division of Hematology/Oncology 1Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.; 2Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China. Department of Hepatobiliary Surgery, First Affiliated Hospital, Xi’an Jiaotong University, Xi’an, China Department of Forensic Medicine, Hainan Tropical Forensic Engineering Research Center, Hainan Medical University , Haikou , China Department of Vascular Surgery, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China; Shanghai Key Laboratory of Vascular Lesions Regulation and Remodeling, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai, China Department of Pharmacology, School of Basic Medical Sciences, Xi’an Jiaotong University Health Science Center, Xi’an 710061, Shaanxi, P. R. China Department of Neurosurgery, The Fourth Affiliated Hospital, Zhejiang University School of Medicine, Yiwu Jiangsu Key Laboratory for Food Quality and Safety, State Key Laboratory Cultivation Base, Ministry of Science and Technology, Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, P. R. China Department of Grassland Science, College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China Key laboratory of Marine Materials and Related Technologies, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China Shanghai Engineering Research Center of Molecular Therapeutics & New Drug Development, Shanghai Key Laboratory of Green Chemistry & Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing, China Victoria University of Wellington New Zealand Department of Cellular and Molecular Biology, State Key Laboratory of Space Medicine Fundamentals and Application, China Astronaut Research and Training Center, Beijing, China. Key Laboratory of Gas and Fire Control for Coal Mines, China University of Mining and Technology, Ministry of Education, Xuzhou 221116, China; School of Safety Engineering, China University of Mining and Technology, Xuzhou 221116, China School of Physics and Information Engineering, Jiangsu Second Normal University, Nanjing 210013, China Department of Nuclear Medicine, College of Basic Medicine, Chongqing Medical University, Chongqing, China Food Research and Innovation Centre, School of Science, RMIT University, Melbourne, VIC, Australia Department of Urology Sun Yat‐sen Memorial Hospital Sun Yat‐sen (Zhongshan) University Guangzhou China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat‐Sen Memorial Hospital Sun Yat‐Sen University Guangzhou China; Guangdong Provincial Clinical Research Center for Urological Diseases Guangzhou China Department of Biological Sciences, University of Lethbridge, Lethbridge, Canada Key Laboratory of Cluster Science, Ministry of Education of China, School of Chemistry, Beijing Institute of Technology, 5 South Zhongguancun Street, Beijing 100081, P.R. China Department of Neurology Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou China *Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599; Department of Thyroid and Breast Surgery, the Second Hospital of Hebei Medical University, Shijiazhuang, Hebei, China Research Center for Translational Medicine, Shanghai East Hospital, School of Life Sciences and Technology, Tongji University, Shanghai 200092, P. R. China Department of Nephrology Kidney Research Institute West China Hospital of Sichuan University Chengdu China Department of Pathology, The First Affiliated Hospital of Xinjiang Medical University, Urumqi, China Center of Cranio-facial Orthodontics, College of Stomatology Affiliated 9th People's Hospital, Shanghai Jiao Tong University. Department of Obstetrics, Northwest Women’s and Children’s Hospital, Xi’an, Shaanxi 710061, China Department of Chemistry, Chemical Theory Center, Inorganometallic Catalyst Design Center, and Supercomputing Institute, University of Minnesota, 207 Pleasant Street S.E., Minneapolis, Minnesota 55455-0431, United States Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People's Hospital Guangdong Academy of Medical Sciences Guangzhou 510080 China Chemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China School of Life Sciences The Chinese University of Hong Kong Shatin, NT Hong Kong P.R. China School of Chemistry and Chemical Engineering Xi'an University of Science and Technology Xi'an 710054 China Department of Medical Environmental Biology and Tropical Medicine, School of Medicine, Kangwon National University, Chuncheon, Gangwon-do, Republic of Korea Shanghai Key Laboratory of Agricultural Genetics and Breeding Biotechnology Research Institute of Shanghai Academy of Agricultural Sciences Shanghai 201106 China Division of Pediatric Cardiology, Department of Pediatrics, Emory University School of Medicine, 1648 Pierce Dr NE, Atlanta, GA 30307, USA; Children's Heart Research & Outcomes (HeRO) Center, Children's Healthcare of Atlanta & Emory University, Atlanta, GA, USA Department of Pathology The First Affiliated Hospital College of Medicine Zhejiang University Hangzhou China for the TESTING Study Group CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China Interconnected & Integrated Bioelectronics Lab (I2BL); Department of Electrical and Computer Engineering; University of California; Los Angeles; USA Department of Life Science and Technology, Mudanjiang Normal University, Mudanjiang, Heilongjiang, China Center for Translational Medicine First Affiliated Hospital of Xi’an Jiaotong University Xi’an China; Key Laboratory for Tumor Precision Medicine of Shaanxi Province First Affiliated Hospital of Xi’an Jiaotong University Xi’an China Department of Paediatrics, The First Affiliated Hospital of Henan University of Science and Technology, Luoyang, Henan, China Institute of Photomedicine Shanghai Skin Disease Hospital, Tongji University School of Medicine Shanghai China Biotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences, Yunnan Provincial Key Lab of Agricultural Biotechnology, Key Lab of Southwestern Crop Gene Resources and Germplasm Innovation, Ministry of Agriculture, Kunming, Yunnan 650205, P.R. China Department of Urology, Sun Yat-sen Memorial Hospital; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Guangzhou, China Centre for Advanced Optoelectronic Functional Materials Research and Key Laboratory for UV Light-Emitting Materials and Technology of Ministry of Education, Northeast Normal University, Changchun, Jilin 130024, China; State Key Laboratory of Metastable Materials Science & Technology and Key Laboratory for Microstructural Material Physics of Hebei Province, School of Science, Yanshan University, Qinhuangdao, Hebei 066004, China School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459, Institute of Chemical and Engineering Sciences, Singapore 627833, School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, and Research Center for Applied Science, Academia Sinica, Taiwan Computer Engineering Technical College, Guangdong Polytechnic of Science and Technology, Zhuhai Guangdong, China Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY 14853, USA. Key Laboratory of Cluster Science, Ministry of Education of China, School of Chemistry, Beijing Institute of Technology, Beijing 100081, People's Republic of China Department of Chemistry, The Pennsylvania State University, University Park, Pennsylvania 16802, United States Department of Hematological Laboratory Science, Jiangsu Key Laboratory of Medical Science and Laboratory Medicine, School of Medicine, Jiangsu University, Zhenjiang 212013, China Department of Neurology Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang China *Microbiology and Immunology and National Laboratory of Solid State Microstructures College of Engineering and Applied Sciences Frontiers Science Center for Critical Earth Material Cycling Nanjing University Nanjing 210023 China Department of Thoracic Surgery Shanghai Pulmonary Hospital School of Medicine Tongji University Shanghai 200433 China Key Laboratory of Cluster Science; Ministry of Education School of Chemistry; Beijing Institute of Technology; Beijing 100081, P. R. China Scientific Research Center The Seventh Affiliated Hospital Sun Yat‐sen University Shenzhen Guangdong 518107 China School of Chemical Engineering and Light Industry Guangdong University of Technology Guangzhou 510006 P.R. China Wide Bandgap Semiconductor Technology Disciplines State Key Laboratory School of Microelectronics, Xidian University, Xi’an710071, China Jilin Provincial Key Laboratory of Science and Technology for Stomatology Nanoengineering, School of Stomatology, Jilin University, Changchun, China Materials Research Institute/Department of Materials Science and Engineering Pennsylvania State University University Park PA 16802 USA Biotechnology Research Institute Shanghai Academy of Agricultural Sciences Shanghai 201106 China; Shanghai Key Laboratory of Agricultural Genetics and Breeding Shanghai Academy of Agricultural Sciences Shanghai 201106 China; Key Laboratory for Safety Assessment (Environment) of Agricultural Genetically Modified Organisms Ministry of Agriculture and Rural Affairs Shanghai 201106 China Clean Nano Energy Center, State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004, P.R. China Department of Kidney Disease and Blood Purification Institute of Urology & Key Laboratory of Tianjin The Second Hospital of Tianjin Medical University Tianjin China Department of Urology, Nanjing Drum Tower Hospital, Medical School of Nanjing University, Nanjing University, Nanjing, Jiangsu 210008, P.R. China From the Research Division (Z.H., D.M.O., K.J.W., K.U., R.N.K., R.K., G.L.K.), Joslin Diabetes Center, Harvard Medical School, the Cardiovascular Division (N.B., P.M.K., S.I.), Beth Israel Deaconess Medical Center, Harvard Medical School, and theWhitaker Cardiovascular Institute (B.W., R.L.), Boston University Medical School, Boston, Mass. Current affiliation for B.W. and R.L.: Cardiovascular Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, Mass. Department of Urology , Meishan People’s Hospital, Meishan Key Laboratory of Cluster Science, Ministry of Education of China, Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, School of Chemistry, Beijing Institute of Technology, Beijing 100081, P. R. China Department of Marine Biotechnology, Faculty of Naval Medicine, Navy Medical University, Shanghai, China Department of Surgical Pathology, the First Affiliated Hospital Jiangxi Provincial Key Laboratory of Camellia Germplasm Conservation and Utilization, Jiangxi Academy of Forestry, Nanchang, China Northwest Institute of Plateau Biology Chinese Academy of Science Xining China; University of Chinese Academy of Science Beijing China Institute of Functional Nano and Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-based Functional Materials and Devices Soochow University Suzhou 215123 China Jiangsu Key Laboratory for Food Quality and Safety, State Key Laboratory Cultivation Base of Ministry of Science and Technology, Jiangsu Academy of Agricultural Sciences, Institute of Plant Protection , Nanjing, Jiangsu, China Department of Orthopaedics, First Affiliated Hospital of Dalian Medical University, Dalian, China; Key Laboratory of Molecular Mechanism for Repair and Remodeling of Orthopaedic Diseases, Liaoning Province, China Department of Medicine, University of Florida College of Medicine, Gainesville, FL 32610. College of Animal Science and Technology, Northeast Agricultural University, Harbin 150030, China Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China Institute of Biological Control, Plant Protection College, Fujian Agriculture and Forestry University, Fuzhou, China; Key Laboratory of Biopesticide and Chemical Biology, Ministry of Education, Fuzhou, China State Key Laboratory of Marine Coatings, Qingdao 266071, China; Marine Chemical Research Institute Co., Ltd., Qingdao 266071, China Shaanxi Key Laboratory of Chemical Additives for Industry; College of Chemistry and Chemical Engineering; Shaanxi University of Science and Technology; Xi’an; China Department of Thoracic Surgery, Shanghai Tenth People’s Hospital, Shanghai, China The University of Texas at Austin, Austin, TX, USA. Department of Interventional Neuroradiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China Huazhong Agricultural University, National Key Laboratory of Crop Genetic Improvement and National Center of Plant Gene Research Department of Ultrasonic Imaging, Affiliated Renhe Hospital of China Three Gorges University, Yichang School of Materials Science & Engineering; Zhengzhou University; Zhengzhou 450001; China *Cancer Center, Chinese People’s Liberation Army General Hospital, Beijing 100853, People’s Republic of China; Department of Pediatrics, Shenzhen Second People’s Hospital, Shenzhen, Guangdong, China Department of Gastroenterology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China Xinjiang Laboratory of Special Environmental Microbiology, Urumqi 830091, Xinjiang, PR China; Institute of Applied Microbiology, Xinjiang Academy of Agricultural Sciences, Xinjiang, Urumqi 830091, PR China State Key Laboratory of Palaeobiology and Stratigraphy Nanjing Institute of Geology and Palaeontology and Center for Excellence in Life and Paleoenvironment Chinese Academy of Sciences Nanjing China College of Food Science, Northeast Agricultural University, Harbin, Heilongjiang, China Department of Earth & Environment Boston University Boston MA USA Division of Gastroenterology and HepatologyRenji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai Institute of Digestive DiseaseShanghaiChina State Key Laboratory of Natural Medicines, Department of Organic Chemistry, China Pharmaceutical University, Nanjing, 210009, P. R. China Institute of Forensic Medicine and Laboratory Medicine, Jining Medical University , Jining City , 272067, Shandong Province , China Institute of Occupational Health and Environmental Health, School of Public Health Lanzhou University Lanzhou Gansu China Department of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China College of Chemistry, Beijing Normal University, Beijing, 100875, China Department of Oncology, First Affiliated Hospital of Jiamusi University, Jiamusi, Heilongjiang 154002, P.R. China Department of Gastroenterological Surgery, Peking University People's Hospital, Beijing, 100044, PR China; Laboratory of Surgical Oncology, Peking University People's Hospital, Beijing, 100044, PR China State Key Laboratory of Toxicology & Medical Countermeasures, Beijing Institute of Pharmacology & Toxicology, Beijing 100850, People’s Republic of China Department of Cardiology The First Affiliated Hospital of Zhengzhou University Zhengzhou Henan China; Henan Province Key Laboratory of Cardiac Injury and Repair Zhengzhou Henan China Department of Orthopedics and Trauma, Key Laboratory of Trauma and Neural Regeneration (Ministry of Education/Peking University Peking University People’s Hospital Beijing 100044 China School of Pharmacy University of Wisconsin-Madison 777 Highland Avenue Madison WI 53705 USA Department of Laboratory Medicine, The Second Hospital of Chongqing Medical University, Chongqing 400010, China Key Laboratory of Marine Genetics and Breeding, Ministry of Education, College of Marine Life Sciences, Ocean University of China Department of Neurosurgery Beijing Tiantan Hospital, Capital Medical University Beijing China School of Chemistry and Chemical Engineering, Shandong University, Jinan 250100, People’s Republic of China College of Pharmacy, Guizhou University of Traditional Chinese Medicine, Guiyang, People’s Republic of China Authors' Affiliation: Pancreatic Disease Institute, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China College of Life Science, Henan Agricultural University, Zhengzhou 450002, China Juvenile Diabetes Research Foundation Danielle Alberti Memorial Centre for Diabetes Complications, Diabetes Division, Baker IDI Heart and Diabetes Institute, Victoria, Australia; Joint Proteomics Laboratory, Ludwig Institute for Cancer Research and the Walter and Eliza Hall Institute of Medical Research, Parkville, Victoria, Australia, and Department of Surgery, Royal Melbourne Hospital, The University of Melbourne, Parkville, Victoria, Australia Department of Medical Oncology, Cancer Center, Sun Yat-sen University, Guangzhou, Guangdong 510060, P.R. China. Department of Gastroenterology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Anatomy and Developmental Biology, Biomedicine Discovery Institute, Monash University, Clayton Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education; College of Chemistry, Peking University; Beijing 100871, China Chinese Human Genome Center North Beijing, Beijing 100176, People's Republic of China; Center for Genomics and Bioinformatics, Karolinska Institutet, 171 77 Stockholm, Sweden; and Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, National Laboratory of Medical Molecular Biology, Beijing 100005, People's Republic of China Department of Systems and Computational Biology, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, United States Department of Polymer Materials, School of Materials Science and Engineering, Shanghai University, No. 99 Shangda Road, Shanghai 200444, P. R. China College of Chemistry, Chemical Engineering and Materials Science, Collaborative Innovation Center of Functionalized Probes for Chemical Imaging in Universities of Shandong, Key Laboratory of Molecular and Nano Probes, Ministry of Education, Shandong Normal University, Jinan 250014, P. R. China College of Materials Science and Engineering, Wuhan Textile University, Wuhan 430200, China Department of Hepatobiliary Surgery The First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi China; Institute of Advanced Surgical Technology and Engineering The First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi China Life and Health Intelligent Research Institute School of Chemistry and Chemical Engineering Tianjin University of Technology Tianjin 300384 P. R. China Department of Pathology, Dalian Medical University, Dalian 116044, China Sargent Joint Research Center, Wuhan National Laboratory for Optoelectronics (WNLO), School of Optical and Electronic Information, Huazhong University of Science and Technology (HUST), Wuhan, Hubei 430074, China Department of Pediatrics, Guangdong Women and Children’s Hospital, Guangzhou, China Department of Urology, Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou China Division of Family Medicine and Primary Health Care, Jockey Club School of Public Health, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China; Department of Pathology and Forensic Medicine, College of Basic Medical Science, Dalian Medical University, Dalian, Liaoning 116044, P.R. China Key Laboratory of Cluster Science; Ministry of Education of China; School of Chemistry; Beijing Institute of Technology; Beijing, P. R. China College of Chemistry and Environmental Science, Hebei University, Baoding 071002, Hebei, China National Key Laboratory for Remanufacturing, Academy of Armored Force Engineering, Beijing 100072, China School of Chemistry Sun Yat-Sen University Guangzhou 510275 P. R. China Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, P. R. China, Department of Radio Engineering, Southeast University, Nanjing, P. R. China, Department of Materials Science and Engineering, University of Illinois, Urbana, Illinois 61801, and Max Planck Institute of Colloids and Interfaces, D-14424 Potsdam, Germany Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials Key Laboratory of Cluster Science Ministry of Education School of Chemistry and Chemical Engineering Beijing Institute of Technology Beijing 100081 P. R. China Institute of Transfusion Medicine, Academy of Military Medical Sciences, Beijing 100850, China Barrer Centre Department of Chemical Engineering Imperial College London London SW7 2AZ UK Department of Respiratory Medicine, Xi'an Central Hospital, Xi’an 710004, China Chemical Engineering Research Center School of Chemical Engineering and Technology Tianjin University Tianjin 300072 China; Collaborative Innovation Center of Chemical Science and Engineering (Tianjin) Tianjin 300072 China; Tianjin Key Laboratory of Membrane Science and Desalination Technology State Key Laboratory of Chemical Engineering, Tianjin University Tianjin 300072 China Department of Chemistry, Pennsylvania State University, University Park, Pennsylvania 16802, United States Department of Respiratory and Critical Care Medicine, Xi’an Central Hospital, Xi’an, P.R. China Department of Chemistry, Chemical Theory Center, and Supercomputing Institute, University of Minnesota, Minneapolis, Minnesota 55455-0431, United States Ab Studio , Inc., Hayward, CA 94545 , USA METRIC Group, Mayo Clinic, Rochester, MN, USA Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials Key Laboratory of Cluster Science Ministry of Education of China School of Chemistry and Chemical Engineering Beijing Institute of Technology Beijing 100081 P. R. China Translational Medicine Research Center, Shanxi Medical University, 56 South Xijian Nan Road, Taiyuan, Shanxi 030001, China Department of Laboratory Medicine Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine Shanghai P.R. China Department of Orthopedics, Shanghai Changzheng Hospital, Second Military Medical University, Shanghai, China School of Chemistry Sun Yat-sen University Guangzhou 510006 P. R. China Department of Cardiology , The Second Affiliated Hospital of Harbin Medical University , 246 Xuefu Road , Harbin 150001 , Heilongjiang Province , China; The Key Laboratory of Myocardial Ischemia , Harbin Medical University, Ministry of Education , Harbin 150086 , Heilongjiang Province , China School of Materials Science and Engineering, Shanghai University, Shanghai, 200444, P. R. China Department of Neurosurgery, The First Affiliated Hospital of Xi’an Jiaotong University, 277 West Yanta Road, Xi’an, Shaanxi 710061, China Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China Isotopomics in Chemical Biology (ICB), School of Chemistry and Chemical Engineering, Shaanxi University of Science and Technology, Xi’an 710021, China Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Biological Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.; Department of Chemistry, University of Michigan, Ann Arbor, MI48109, USA.; Department of Microbiology and Immunology, University of Michigan, Ann Arbor, MI 48109, USA. Zanthoxylum Bungeanum Research Institute, Longnan Economic Forest Research Institute, Longnan, China State Key Laboratory of Fluorine & Nitrogen Chemicals, Xi'an Modern Chemistry Research Institute, Xi'an, Shaanxi 710065, China National Key Laboratory of Crop Genetic Improvement Huazhong Agricultural University Wuhan Hubei 430070 China National Key Laboratory of Crop Genetic Improvement, Huazhong Agricultural University, Wuhan, Hubei 430070, China Chemical and Biomolecular Engineering Department; University of California; Los Angeles; Los Angeles; USA Key Laboratory of Functional Inorganic Material Chemistry, Ministry of Education of the People’s Republic of China, Heilongjiang University, Harbin 150080, P. R. China Tsinghua University Department of Physics and Astronomy; Clemson University; Clemson; USA Peking University School and Hospital of Stomatology National Engineering Laboratory for Digital and Material Technology of Stomatology Beijing Key Laboratory of Digital Stomatology, Chinese Stomatological Association Beijing China College of Life Sciences, Agricultural University of Hebei, Baoding 071001, China. School of Applied Physics and Materials; Wuyi University; Jiangmen; P. R. China Center for Composite Materials and Structure, Harbin Institute of Technology, Harbin 150001, China Authors' Affiliations: 1Department of Molecular and Cellular Biochemistry, 2Comprehensive Cancer Center, 3Department of Molecular Virology, Immunology and Medical Genetics, 4Department of Pathology, 5Department of Internal Medicine, Davis Heart and Lung Research Institute, and 6Center for Molecular Neurobiology, The Ohio State University, Columbus, Ohio State Key Laboratory of Toxicology and Medical Countermeasures, Beijing Institute of Pharmacology and Toxicology , Beijing 100850, China School of Mechanical and Aerospace Engineering, Oklahoma State University, Stillwater, OK 74078 e-mail: Key Laboratory of Applied Chemistry in Hebei Province Yanshan University Qinhuangdao 066004 China BGI-Shenzhen Department of Surgery The Fourth Affiliated Hospital, China Medical University Shenyang China Hebei Key Laboratory of Flexible Functional Materials School of Materials Science and Engineering Hebei University of Science and Technology Shijiazhuang 050000 China †Department of Toxicology, Anhui Medical University, Hefei 230032, China;; ‡Key Laboratory of Environmental Toxicology of Anhui Higher Education Institutes, Anhui Medical University, Hefei 230032, China; and College of Animal Science and Technology, Yunnan Agricultural University, Kunming 650201, China Department of Orthopedics, Shanghai Changzheng Hospital Naval Medical University Shanghai China Department of Population and Quantitative Health Sciences University of Massachusetts Medical School Worcester Massachusetts USA State Key Laboratory of Virology and National Virus Resource Center, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, People’s Republic of China; University of Chinese Academy of Sciences, Beijing, People’s Republic of China Department of Pharmaceutics School of Pharmacy, China Pharmaceutical University Nanjing Jiangsu China Henan Key Laboratory of Special Protective Materials, Materials Science and Engineering School, Luoyang Institute of Science and Technology, Luoyang, 471023, P. R. China Key Laboratory of Aerospace Advanced Materials and Performance of Ministry of Education; School of Materials Science and Engineering; Beihang University; Beijing; China Department of Hepatobiliary Surgery, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China China National GeneBank, BGI Research , Shenzhen 518120 , China Jilin Provincial Key Laboratory of Straw-Based Functional Materials, Institute for Interdisciplinary Biomass Functional Materials Studies, Jilin Engineering Normal University, Changchun 130052, P. R. China State Key Laboratory of Animal Nutrition Collage of Animal Science and Technology China Agricultural University Beijing China State Key Laboratory of Antiviral Drugs, Pingyuan Laboratory, NMPA Key Laboratory for Research and Evaluation of Innovative Drug, School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang, Henan 453007, China School of Life Sciences; The Chinese University of Hong Kong; Shatin; China Department of Materials Science and Engineering, The Pennsylvania State University, University Park, Pennsylvania 16802, United States Institute of Engineering Thermophysics, Chinese Academy of Sciences, 11 North Fourth Ring West Road, Beijing, 100190, People’s Republic of China School of Electrical and Computer Engineering; Jilin Jianzhu University; Changchun 130118; China School of Pharmacy, Health Science Center, Xi'an Jiaotong University, Xi'an, Shaanxi 710061, P.R. China Lachman Institute for Pharmaceutical Development, School of Pharmacy University of Wisconsin-Madison Madison WI 53705 USA State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry Fuzhou University Fuzhou 350002 China Department of Medical Technology, West China School of Public Health, Sichuan University, Chengdu 610041, China. Department of Materials Science and Engineering, Pennsylvania State University, University Park, PA 16802, USA. Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials Key Laboratory of Cluster Science Ministry of Education Advanced Technology Research Institute (Jinan) Frontiers Science Center for High Energy Material School of Chemistry and Chemical Engineering Beijing Institute of Technology No. 5, South Street, Zhongguancun, Haidian District Beijing 100081 China School of Optical and Electronic Information, Wuhan National Laboratory for Optoelectronics (WNLO), Huazhong University of Science and Technology, Wuhan 430074, China Departments of Gastroenterological Surgery and Surgical Oncology Peking University People's Hospital Beijing China Department of Biochemistry and Cell Biology, Rice University, Houston, Texas 77005 Department of Spine Surgery, Daxing Hospital, Xi’an 710016, Shaanxi, China Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, School of Engineering Medicine, Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beihang University; X-Laboratory for Ion-Channel Engineering, Beihang University Australian Centre for Advanced Photovoltaics University of New South Wales Sydney 2052 Australia Key Laboratory of Chemical Additives for China National Light Industry; College of Chemistry and Chemical Engineering; Shaanxi University of Science and Technology; Xi’an; China Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, 199 Ren’ai Road, Suzhou 215123, China Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education of China, Key Laboratory of Henan Province for Drug Quality and Evaluation, School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, Henan, 450001, P.R. China; State Key Laboratory of Esophageal Cancer Prevention & Treatment, Zhengzhou University, Zhengzhou, Henan, 450052, P.R. China School of Chemistry, Sun Yat-sen University, Guangzhou, China China National GeneBank, Shenzhen 518120, China Department of Cardiology, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai, China. Peter Munk Cardiac Centre, Toronto General Hospital, Canada (A.T., B.W., S.E., Y.S., F.B., P.R.L.).; Department of Medicine (A.T., C.d.S., B.W., S.E., Y.S., F.B., P.R.L.), University of Toronto, Canada. State Key Lab of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences Changchun 130022 China Department of Biochemistry and Molecular Biology, Guangxi Medical University, Nanning 530021, Guangxi, P.R. China Department of Cardiology, Guangdong Provincial Key Laboratory of Coronary Heart Disease Prevention, Guangdong Cardiovascular Institute, Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences, Guangzhou 510080, China School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, People’s Republic of China School of Life Science Tsinghua University Beijing 100084 China School of Chemistry, Sun Yat-sen University, Guangzhou 510006, China Institute of Photomedicine, Shanghai Skin Disease Hospital, Tongji University School of Medicine, Shanghai, 200443, PR China Medical Department, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan 250021, China Department of Pharmacology, School of Basic Medical Sciences, Xi'an Jiaotong University Health Science Center , Xi'an, Shaanxi, P. R. China Department of Orthopedics Tongji Hospital Tongji Medical College, Huazhong University of Science and Technology Wuhan Hubei China Central University of Finance and Economics Department of Obstetrics and Gynaecology, The Third People’s Hospital of Taiyuan, Taiyuan, Shanxi, China Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China Tianjin Key Laboratory of Refrigeration, School of Mechanical Engineering, Tianjin University of Commerce, Tianjin, China School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, China Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou, Jiangsu 215123, P.R. China Department of Cardiology, Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai China Department of Ultrasound, Xijing Hypertrophic Cardiomyopathy Center, Xijing Hospital, Fourth Military Medical University, Xi’an, Shannxi, China College of Veterinary Medicine Northwest A&F University Yangling Shaanxi PR China; Key Laboratory of Animal Biotechnology of the Ministry of Agriculture Northwest A&F University Yangling Shaanxi PR China Department of Marine Biomedicine and Polar Medicine, Naval Special Medical Center, Naval Medical University, Shanghai 200433, China Department of Laboratory Medicine Dalian Municipal Central Hospital Liaoning China Departments of Pathology, The First Affiliated Hospital, Xinjiang Medical University , Urumqi , Xinjiang 830011 , People’s Republic of China From the Whitaker Cardiovascular Institute and Amyloid Treatment and Research Program, Evans Department of Medicine, Boston University School of Medicine, Boston, Mass. Department of Urology Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guangzhou China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation Sun Yat‐Sen Memorial Hospital Sun Yat‐Sen University Guangzhou China Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming, China Department of Laboratory Medicine Shanghai Children's Medical Center, Shanghai Jiao Tong University School of Medicine Shanghai P.R. China School of Astronautics, Northwestern Polytechnical University, Xi’an 710072, China Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, PR China Department of Pathology, Creighton University Medical Center, Omaha, NE 68131, USA Department of Applied Chemistry, China Agricultural University, Yuanmingyuan West Road 2, Beijing 100193, China State Key Laboratory of Protein and Plant Gene Research School of Life Sciences Peking University Beijing China *Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599; State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550081, China; University of Chinese Academy of Sciences, Beijing 100049, China School of Materials Science and Engineering, University of Jinan, Jinan 250022, China Department of Hematology, The First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, Zhejiang 310006, P.R. China Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China Key Laboratory of Organo-Pharmaceutical Chemistry of Jiangxi Province, Gannan Normal University, Ganzhou 341000, China Department of Thoracic Surgery, Chinese PLA General Hospital, Beijing, China State Key Laboratory of Crop Stress Biology for Arid Areas, and Key Laboratory of Northwest Loess Plateau Crop Pest Management of Ministry of Agriculture, Northwest A&F University, Yangling, Shaanxi, China Scientific Computing and Imaging Institute, University of Utah, Salt Lake City, Utah.; School of Computing, University of Utah, Salt Lake City, Utah. Isotopomics in Chemical Biology & Shaanxi Key Laboratory of Chemical Additives for Industry, School of Chemistry & Chemical Engineering, Shaanxi University of Science & Technology, Xi’an 710021, China School of Chemical and Biomedical Engineering, Nanyang Technological University, 637722, Singapore Department of Respiratory Medicine The 2nd Affiliated Hospital of Harbin Medical University Harbin China Chemistry Department, Technische Universität München, 85748 Garching, Germany Department of Biomedical and Chemical Engineering and Sciences, Florida Institute of Technology, Melbourne, Florida, USA. Department of Ophthalmology, University of Pittsburgh School of Medicine, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, Pittsburgh, Pennsylvania, United States 2Department of Bioengineering, Swanson School of En Department of Rehabilitation, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Tiexi, Shenyang 110000, Liaoning, People’s Republic of China Victoria University of Wellington Department of Pharmacology, Beijing Institute of Pharmacology and Toxicology, Beijing 100850, China Department of Cardiology, First Hospital of China Medical University, 155 Nanjing North Street, Heping District, Shenyang 110001, China 1Molecular and Cellular Biochemistry, Departments of; 5Comprehensive Cancer Center, Ohio State University, Columbus, Ohio From the Department of Interventional Neurology, Beijing Tiantan Hospital, Capital Medical University, China (X.S., D.M., F.G., N.M., B.W., Z.M.); Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, China (X.S., D.M., F.G., N.M., B.W., Z.M.); China National Clinical Research Center for Neurological Diseases Center of Stroke, Beijing (X.S., D.M., F.G., N.M., B.W., Z.M.); Beijing Institute for Brain Disorders, China (X.S., D.M., F.G., N.M., B.W., Z.M.); Department of... Beijing Key Laboratory of Lignocellulosic Chemistry, Beijing Forestry University, No 35, Tsinghua East Road, Haidian District, Beijing 100083, China Department of Ultrasound, Xijing Hypertrophic Cardiomyopathy Center, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China State Key Laboratory of Virology, Wuhan Institute of VirologyChinese Academy of Sciences 430071 Wuhan China Gallbladder Disease Center, Tongji University Affiliated Shanghai East Hospital, Shanghai, China Department of Pathology, The First Affiliated Hospital, College of Medicine, Zhejiang University Hangzhou, China. Beijing National Laboratory of Molecular Sciences (BNLMS); Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education; College of Chemistry; Peking University; Beijing 100871 Graduate School of Information, Production & Systems, Waseda University, Hibikino 2-7, Wakamatsu-ku, Kitakyshu, Fukuoka, Japan Department of Neurology The Second Affiliated Hospital, Zhejiang University School of Medicine Hangzhou Zhejiang China From the Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina Department of Pharmacology, Xi’an Jiaotong University Health Science Center Xi’an, Shaanxi 710061, China. Department of Thoracic Surgery, General Hospital of PLA Beijing 100853, China. Biotechnology Research Institute of Shanghai Academy of Agricultural Sciences Shanghai Key Laboratory of Agricultural Genetics and Breeding Shanghai China Department of Quantitative Health Sciences, University of Massachusetts Medical School, Worcester, MA, USA; Department of Cardiology, Children’s Hospital of Soochow University, Suzhou, Jiangsu, China MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage, School of Chemistry and Chemical Engineering, Harbin Institute of Technology, No. 92 West Dazhi Street, 150001 Harbin, China Department of Otolaryngology‐Head & Neck Surgery Fuyang People's Hospital Fuyang China Department of Gastroenterological Surgery; Peking University People's Hospital; Beijing, PR China Department of Oncology, The Second Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215004, P.R. China State Key Laboratory for Animal Disease Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, People’s Republic of China Center for Reticular Chemistry at California NanoSystems Institute, Department of Chemistry and Biochemistry, University of California at Los Angeles, 607 East Charles E. Young Drive, Los Angeles, CA 90095, USA.; Department of Chemistry and Biochemistry, Arizona State University, Tempe, AZ 85287, USA. School of Chemical Engineering, Sichuan University, Chengdu, Sichuan 610065, People’s Republic of China Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive Disease, Shanghai, China Key Laboratory of Special Pathogens and Center for Emerging Infectious Diseases, Wuhan Institute of Virology, Chinese Academy of Sciences, Wuhan, China School of Chemistry and Life Science, Changchun University of Technology, Changchun, Jilin 130012, China College of Life Science, Yantai University, Yantai 264000, China Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, Shanghai 200237, China School of Materials Science and Engineering, Hefei University of Technology, Hefei, 230009, PR China School of Chemistry and Chemical Engineering and Key Laboratory of Colloid and Interface Chemistry of Ministry of Education; Shandong University; Jinan 250100, PR China Diabetes Division, JDRF Danielle Alberti Memorial Centre for Diabetes Complications, Melbourne, Australia; Isotopomics in Chemical Biology & Shaanxi Key Laboratory of Chemical Additives for Industry, School of Chemistry & Chemical Engineering Shaanxi University of Science & Technology, Weiyang University Park Xi'an 710021 China Wuhan National Laboratory for Optoelectronics Huazhong University of Science and Technology Wuhan 430074 P. R. China State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, Beijing, China Frontiers Science Center for High Energy Material Advanced Technology Research Institute (Jinan) Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials School of Chemistry and Chemical Engineering Beijing Institute of Technology Beijing 100081 P. R. China Department of Neurology, the Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang China Department of Orthopaedics, Guizhou Provincial People's Hospital, Guiyang 550002, Guizhou, China CAS Key Laboratory of Tropical Forest Ecology, Xishuangbanna Tropical Botanical Garden, Chinese Academy of Sciences, Mengla 666303, China Beijing Key Laboratory of Lignocellulosic Chemistry Beijing Forestry University Beijing 100083 PR China Department of Gynecology, Maternal and Child Health Hospital of Hubei Province, Wuhan, Hubei 430070, P.R. China CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou, China College of Veterinary Medicine, Northwest A&F University, Yangling, 712100, Shaanxi, China.; Key Laboratory of Animal Biotechnology, Ministry of Agriculture, Northwest A&F University, Yangling, 712100, Shaanxi, China.; These authors contributed equally to this article. Department of Clinical Laboratory, The First Affiliated Hospital of Jinzhou Medical University, Jinzhou, Liaoning 121001, P.R. China Institute of Forensic Medicine and Laboratory Medicine, Jining Medical University, Jining, Shandong 272067, P.R. China National Research Center for Wildlife‐Borne Diseases Institute of Zoology Chinese Academy of Sciences Beijing China; University of Chinese Academy of Sciences Beijing China Institute of Organic Chemistry & MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, School of Chemistry, Sun Yat-Sen University, Guangzhou, Guangdong 510006, P. R. China Biotechnology Research Institute, Tianjin Academy of Agricultural Sciences, Tianjin, China Department of Urology, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou 510120, China The Program On Regulation, Therapeutics, and Law, Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, Massachusetts Authors' Affiliations: 1Institute of Pathogen Biology, 2Department of Biochemistry, Shandong University School of Medicine; 3Department of Traditional Chinese Medicine, 4Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education and Chinese Ministry of Public Health, Qilu Hospital, Shandong University; and 5Department of Pathology, Jinan Central Hospital, Jinan, China Department of Chemistry and Supercomputing Institute, University of Minnesota, 207 Pleasant Street South East, Minneapolis, Minnesota 55455-0431 Department of Neurosurgery, the First Affiliated Hospital of Xi’an Jiaotong University Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, China. Department of Ophthalmology, UPMC Eye Center, Eye and Ear Institute, Ophthalmology and Visual Science Research Center, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania 2Department of Bioengineering, Swanson School of Engineering, Univ Department of Anesthesiology, The First Affiliated Hospital, University of South China, Hengyang, Hunan 421001, P.R. China From the Cancer Biology Program, Division of Hematology/Oncology, Department of Medicine, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Mass (M.I.K., W.Y., K.K.B., B.G.N.); Cardiovascular Medicine Division, Brigham and Women’s Hospital, Harvard Medical School, Boston, Mass (D.C., B.W., R.L.); Cardiovascular Division, Beth Israel Deaconess Medical Center, Boston, Mass (N.B., Q.K., P.M.K.); and Cardiovascular Research Program, Hospital for Sick Children and Department of... Beijing National Laboratory of Molecular Sciences (BNLMS) and Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education College of Chemistry Peking University Beijing 100871 China Department of Oral and Craniomaxillofacial Science Key Laboratory of Cluster Science; Ministry of Education of China; Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials; School of Chemistry; Beijing Institute of Technology Department of Orthopedics, Affiliated Zhongshan Hospital of Dalian University, Dalian, China Department of Traditional Chinese Medicine Qilu Hospital Shandong University Jinan Shandong China University of Massachusetts, USA The key Laboratory of Industrial Biotechnology, School of Biotechnology Jiangnan University Wuxi China College of Chemistry and Chemical Engineering; Liaocheng University; Liaocheng; P. R. China School of Material Sciences and Engineering; Hefei University of Technology; Hefei 230009; China Department of Tuberculosis Medicine, Xi’an Chest Hospital, Xi’an, Shaanxi, PR China Center for Reticular Chemistry, Department of Chemistry and Biochemistry, University of California-Los Angeles, 607 Charles E. Young Drive East, Los Angeles, California, 90095-1569 School of Petrochemical Technology, Lanzhou University of Technology, Lanzhou 730050, China Department of Cardiology The First Affiliated Hospital of Zhengzhou University Zhengzhou China; Henan Province Key Laboratory of Cardiac Injury and Repair Zhengzhou China; Henan Province Clinical Research Center for Cardiovascular Diseases Zhengzhou Henan China Department of Materials Science and Engineering The Pennsylvania State University University Park PA 16802 USA Department of Radiology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China Department of Thyroid and Vascular Surgery; Department of General Surgery; Minimal Invasive Center, Fujian Medical University Union Hospital; Fujian Medical University, Fuzhou, Fujian Province, China. Department of Physics and Astronomy and ‡Department of Environmental Engineering and Earth Sciences, Clemson University, Clemson, South Carolina 29634, United States CAS Key Laboratory of Colloid Interface and Chemical Thermodynamics CAS Research/Education Center for Excellence in Molecular Sciences Beijing National Laboratory for Molecular Science Institute of Chemistry Chinese Academy of Sciences Beijing 100190 China; University of Chinese Academy of Sciences Beijing 100049 China Department of Neurology Second Affiliated Hospital, School of Medicine, Zhejiang University Hangzhou Zhejiang China University of Massachusetts, Amherst, MA, USA Harbin Institute of Technology Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599 Virus Laboratory, The Affiliated Shengjing Hospital, China Medical University, Shenyang Key Laboratory of Agricultural Measurement and Control Technology and Equipment for Mechanical Industrial Facilities, School of Electrical and Information Engineering, Jiangsu University, Zhenjiang 212013, China Diabetes Division, Juvenile Diabetes Research Foundation Danielle Alberti Memorial Centre for Diabetes Complications, Baker IDI Heart and Diabetes Institute, Melbourne, Australia Department of Neurosurgery, First Affiliated Hospital of Kunming Medical University, Kunming 650032, China Department of Urology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, PR China; Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, PR China Department of Respiratory and Critical Care Medicine, Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu 610041, China School of Physics and Optoelectronic Engineering; Guangdong University of Technology; Guangzhou 510006; China College of Intelligence Science and Technology, National University of Defense Technology, 109 Deya Road, Changsha 410073, China; Laboratory of Science and Technology on Integrated Logistics Support, College of Intelligence Science and Technology, National University of Defense Technology, 109 Deya Road, Changsha 410073, China; Hunan Key Laboratory of Ultra-Precision Machining Technology, Changsha 410073, China Department of Anesthesiology, Peking University International Hospital, Beijing 102206, China Department of Neurosurgery, Xuzhou Central Hospital, Xuzhou, China Medical Department, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, People's Republic of China. State Key Laboratory and Institute of Elemento-organic Chemistry, College of Chemistry, Nankai University, Tianjin 300071, China Indiana University Department of Biochemistry and Molecular Biology, ‡Center for Computational Biology and Bioinformatics, §Department of Chemistry and Chemical Biology (IUPUI), ∥Stark Neurosciences Research Institute, Indiana University School of Medicine, 535 Barnhill Drive, Indianapolis, Indiana 46202, United States Guangxi Key Laboratory of Information Materials, School of Life and Environmental Sciences, Guilin University of Electronic Technology, Guilin 541004, China Department of Chemistry, Chemical Theory Center, and Supercomputing Institute, University of Minnesota, 207 Pleasant Street SE, Minneapolis, Minnesota 55455-0431, United States Key Laboratory of Cluster Science Ministry of Education Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials Advanced Technology Research Institute (Jinan) School of Chemistry and Chemical Engineering Beijing Institute of Technology Beijing 100081 P. R. China Hangzhou Gaoxi Technol Co. Ltd. Hangzhou 310027 P. R. China Department of Immunology, Shandong University School Medicine; School of Materials Science and Engineering, University of Jinan, Jinan, Shandong 250022, China School of Materials Science and Engineering Changchun University of Science and Technology Changchun 130022 P. R. China Center for Multidimensional Carbon Materials (CMCM) Institute for Basic Science (IBS) Ulsan 44919 Republic of Korea College of Chemistry and Chemical Engineering, Central South University, Changsha 410083, Hunan, P. R. China Amoy Diagnostics Co., Ltd. Xiamen China Institut de Génétique et de Biologie Moléculaire et Cellulaire, C.U. de Strasbourg Strasbourg, France MOE Key Laboratory of Macromolecular Synthesis and Functionalization, Department of Polymer Science and Engineering, Zhejiang University, Hangzhou, 310027, P. R. China Division of Pharmacoepidemiology and Pharmacoeconomics, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Boston, Massachusetts Department of Anatomy and Developmental Biology Monash University Melbourne Victoria Australia Department of Orthopaedics Shanghai Tenth People's Hospital Tongji University School of Medicine Shanghai 200072 P. R. China College of Chemistry and Chemical Engineering, Shandong Provincial Key Laboratory of Chemical Energy Storage and Novel Cell Technology, Liaocheng University, Liaocheng 252059, P. R. China CAS Key Laboratory of Tropical Marine Bio-resources and Ecology, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, Guangzhou 510301, China School of Materials Science and Engineering, Nanyang Technological University 50, Nanyang Avenue, Singapore 637819, and School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459 Gastrointestinal Surgery, People’s Hospital of Wenjiang District, 611130 Chengdu City, Sichuan Province, China 1Division of Medical Biochemistry, Institute of Infectious Disease and Molecular Medicine, Faculty of Health Sciences, University of Cape Town, Cape Town, South Africa; 2Centre for Vascular Research, University of New South Wales, Sydney, New South Wales, Australia; 3Cell and Cancer Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, Maryland; and 4Cancer Institute and Hospital, CAMS and PUMC, National Laboratory of Molecular Oncology, Beijing, People's Republic of China Department of Medicine Stanford University School of Medicine Stanford California USA Collaborative Innovation Center of New Drug Research and Safety, Henan Province, PR China;; Key Laboratory of Advanced Drug Preparation Technologies, Ministry of Education, Zhengzhou, Henan Province, PR China;; Key Laboratory of Henan Province for Drug Quality and Evaluation Zhengzhou University, Zhengzhou, Henan Province, PR China;; School of Pharmaceutical Sciences, Zhengzhou University, Zhengzhou, PR China Department of Nutrition and Food Hygiene, West China School of Public Health, Sichuan University, Chengdu 610041, China. Department of Pharmacology, Duke University Medical Center, Durham, North Carolina 27708, and Department of Pharmacology, University of Texas Medical School at Houston, Houston, Texas 77030 Isotopomics in Chemical Biology & Shaanxi Key Laboratory of Chemical Additives for Industry, School of Chemistry & Chemical Engineering, Shaanxi University of Science & Technology, Xi’an, China, 710021 College of Pulmonary and Critical Care Medicine 8th Medical Center of Chinese PLA General Hospital Beijing People's Republic of China Emergency Department, Cangzhou Central Hospital, Cangzhou, China Department of Materials Science and Engineering Pennsylvania State University University Park PA 16802 USA Center for Translational Medicine, The First Affiliated Hospital of Xi’an Jiaotong University, Shanxi 710061, China Department of Microbiology and Immunology University of North Carolina Chapel Hill NC USA Second Affiliated Hospital of Dalian Medical University, Dalian, China , , People’s Republic of China Department of Chemistry, Tulane University, 6400 Freret Street, New Orleans, Louisiana 70118-5698, United States Department of Hepatobiliary Surgery and Institute of Advanced Surgical Technology and Engineering The First Affiliated Hospital of Xi'an Jiaotong University Xi'an China; Shaanxi Provincial Regenerative Medicine and Surgical Engineering Research Center Xi'an China Department of Chemistry, The Pennsylvania State University, University Park, PA, United States. *Department of Microbiology and Immunology, University of North Carolina, Chapel Hill, NC 27599; and Department of Hepatobiliary Surgery,the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,PR China; Institute of Advanced Surgical Technology and Engineering, the First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,PR China; National Local Joint Engineering Research Center for Precision Surgery and Regenerative Medicine,First Affiliated Hospital of Xi'an Jiaotong University,Xi'an,PR China Department of Pathology and Laboratory Medicine, Howard Hughes Medical Institute, University of California, Los Angeles, Los Angeles, United States Jilin University College of Pharmacy, Academy of Integrative Medicine, Dalian Medical University, Lvshun South Road No 9, Dalian 116044, China Center for Translational Medicine, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi, P.R. China; Key Laboratory for Tumor Precision Medicine of Shaanxi Province, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, Shaanxi, P.R. China Department of Ultrasound, Jinan Maternity and Child Care Hospital Shandong First Medical University Jinan China Institute of Food and Nutraceutical Science School of Agriculture and Biology Shanghai Jiao Tong University Shanghai China State Key Laboratory of Hybrid Rice, The College of Life Sciences, Wuhan University , Wuhan 430072 , China Department of Blood Products and Substitutes, Institute of Transfusion Medicine, Academy of Military Medical Sciences, Beijing 100850, PR China School of Pharmacy, Huazhong University of Science and Technology, 13 Hangkong Road, Wuhan 430030, Hubei Province, PR China National Local Joint Engineering Research Center for Precision Surgery & Regenerative Medicine Shaanxi Provincial Center for Regenerative Medicine and Surgical Engineering Institute of Advanced Surgical Technology and Engineering The First Affiliated Hospital of Xi’an Jiaotong University Xi’an China; Department of Hepatobiliary Surgery First Affiliated Hospital Xi’an Jiaotong University Xi’an China Frontiers Science Center for High Energy Material Advanced Technology Research Institute (Jinan) Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials Key Laboratory of Cluster Science School of Chemistry and Chemical Engineering Beijing Institute of Technology Beijing 100081 P. R. China State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, China State Key Laboratory of Virology; Department Gynecology; Cancer Biology Research Center; Tongji Hospital; Tongji Medical College The Second Affiliated Hospital of Inner Mongolia University for the Nationalities, Inner Mongolia General Forestry Hospital, Yakeshi, People’s Republic of China College of Science, Northeast Electric Power University, No. 169 Changchun Road, Jilin City 132012, P. R. China State Key Laboratory of Crop Stress Biology in Arid Areas and College of Plant Protection Northwest A&F University Yangling China Department of Neurosurgery, Beijing Tian Tan Hospital Department of Bioinformatics & Biostatistics, School of Life Science and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China Division of Neonatology, Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan Department of Orthopedic Oncology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China School of Chemistry; Sun Yat-sen University; Guangzhou; China College of Chemistry, Zhengzhou University, Zhengzhou 450001, P. R. China Department of Hepatobiliary Surgery, Xijing Hospital The Fourth Military Medical University Xi'an China Department of Pathology, The First Affiliated Hospital, Zhejiang University, Hangzhou, China Department of Gynecology, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China; Department of Gynecology, Shanghai Key Laboratory of Female Reproductive Endocrine Related Diseases, Obstetrics and Gynecology Hospital, Fudan University, Shanghai 200011, China. Department of Chemistry; Tulane University; New Orleans; USA School of Chemistry and Chemical Engineering Beijing Institute of Technology Beijing 100081 P. R. China Department of Cardiovascular Medicine, The First Hospital of China Medical University , Shenyang 110001 , Liaoning Province , China State Key Laboratory of Brain and Cognitive Science, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, 100101 Beijing, China Department of Neurology, Cang Zhou Central Hospital, Cangzhou, Hebei Province, China National Engineering Laboratory for Biomass Power Generation Equipment; North China Electric Power University; Beijing 102206; China Ecology laboratory of the First Institute of Oceanography SOA, Qingdao, P.R. China, State Key Laboratory of Environmental Geochemistry, Institute of Geochemistry, Chinese Academy of Sciences, Guiyang 550081, China Key Laboratory for Experimental Teratology of Ministry of Education and Department of Immunology, Shandong University School of Medicine, Jinan, Shandong, 250012 P.R. China From the Departments of Pharmaceutical Sciences, Hematology-Oncology, and Biostatistics and Epidemiology, St Jude Children's Research Hospital, and Colleges of Pharmacy and Medicine, University of Tennessee, Memphis, TN. School of Pharmaceutical Sciences, Peking University Health Science Center, Peking University, 38 Xueyuan Road, Beijing, 100083, China Wangjing Hospital, China Academy of Chinese Medical Sciences, Beijing 100102, China. MOE Key Laboratory of Bioinorganic and Synthetic Chemistry, State Key Laboratory of Optoelectronic Materials and Technologies, School of Chemistry and Chemical Engineering, Sun Yat-Sen University, Guangzhou 510275, P. R. China, Beijing National Laboratory for Molecular Sciences, State Key Laboratory of Rare-Earth Materials Chemistry and Applications, College of Chemistry and Molecular Engineering, Peking University, Beijing 100871, P. R. China, and Research Institute of Bioinorganic Chemistry, Department... State Key Laboratory of Fluorine and Nitrogen Chemicals; Xi’an Modern Chemistry Research Institute Departments of †Chemical and Biomolecular Engineering, ‡Materials Science and Engineering, §Chemistry, and ⊥Physics, University of Illinois, Urbana, Illinois 61801, United States Hunan University College of Computer Science and Electronic Engineering, , Changsha, 410083 , China Biological Control Research Institute, Plant Protection College, Fujian Agriculture and Forestry University, Fuzhou 350002, China; China Fruit Fly Research and Control Center of FAO/IAEA, Fuzhou 350002, China; Key Lab of Biopesticide and Chemical Biology, Ministry of Education, Fuzhou 350002, China; State Key Laboratory of Ecological Pest Control for Fujian and Taiwan Crops, Fuzhou 350002, China Beijing Key Laboratory of New Technology in Agricultural Application, National Demonstration Center for Experimental Plant Production Education, Beijing University of Agriculture, Beijing, China Institute of Atomic and Molecular Physics; Jilin University; Changchun 130012; China; Jilin Provincial Key Laboratory of Applied Atomic and Molecular Spectroscopy (Jilin University) Department of Hepatobiliary Surgery First Affiliated Hospital of Xi'an Jiaotong University Xi'an China; Regenerative Medicine and Surgery Engineering Research Center of Shaanxi Province Xi'an China Department of Gastroenterology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, People’s Republic of China Department of Animal Sciences Washington State University Pullman WA USA Key Laboratory of Cluster Science, Ministry of Education of China, Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials, School of Chemistry, Beijing Institute of Technology, Beijing 100081, People’s Republic of China State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, Guangdong Key Laboratory of Marine Materia Medica, RNAM Center for Marine Microbiology, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, P.R. China, and Graduate University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing, 110039, P.R. China Co-Construction Collaborative Innovation Center for Chinese Medicine and Respiratory Diseases By Henan & Education Ministry of PR, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, China; Henan Key Laboratory of Chinese Medicine for Respiratory Disease, Henan University of Chinese Medicine, Zhengzhou 450046, Henan, China Wuhan National Laboratory for Optoelectronics and School of Optical and Electronic Information Huazhong University of Science and Technology Wuhan 430074 China State Key Laboratory of Metastable Materials Science and Technology, Key Laboratory of AppliedChemistry, Yanshan University, Qinhuangdao 066004, China Purdue Pharma L.P., Department of Immunotherapeutics, Cranbury, NJ. Center for Translational Medicine The First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi Province China; Key Laboratory for Tumor Precision Medicine of Shaanxi Province The First Affiliated Hospital of Xi'an Jiaotong University Xi'an Shaanxi Province China The National Engineering Laboratory for Breeding of Endangered Medicinal Materials, Institute of Medicinal Plant Development (IMPLAD) Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Urology, Guizhou Provincial People's Hospital, Guiyang, Guizhou, P.R. China. Department of Gastroenterological Surgery, Surgical Oncology Laboratory, Peking University People's Hospital, Xicheng District, Beijing, China Departments of Chemistry and ‡Biochemistry and Molecular Biology, and the §Howard Hughes Medical Institute, The Pennsylvania State University, University Park, Pennsylvania 16802, United States Key Laboratory of Tibetan Medicine Research Northwest Institute of Plateau Biology Chinese Academy of Sciences Xining 810008 China; University of Chinese Academy of Sciences Beijing 100049 China Carman and Ann Adams Department of Pediatrics, Wayne State University School of Medicine, Detroit, Michigan, USA Key Laboratory of Design and Assembly of Functional Nanostructures, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, P. R. China Research Institute of Photocatalysis; State Key Laboratory of Photocatalysis on Energy and Environment; College of Chemistry; Fuzhou University; Fuzhou 350002 Institute of Chemistry, Chinese Academy of Sciences The Center for Molecular Sciences, , Beijing 100080, China Key Laboratory of Arrhythmias of the Ministry of Education of China and Institute of Heart Failure, Shanghai East Hospital, Tongji University School of Medicine, Shanghai 200120, China Department of Applied Chemistry, China Agricultural University, Beijing 100193, China Department of Laboratory Medicine, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 410010, P.R. China Department of Neurosurgery Southwest Hospital Third Military Medical University (Army Medical University Chongqing China Department of Microbiology and Immunology, State Key Laboratory of Animal Nutrition, College of Animal Science and Technology China Agricultural University Beijing China Institute of Oceanographic Instrumentation, Qilu University of Technology (Shandong Academy of Sciences), Qingdao 266001, China Department of Chemistry and Biochemistry, The Ohio State University, 100 West 18th Avenue, Columbus, Ohio 43210, United States State Key Laboratory of Plant Physiology and Biochemistry, College of Biological Sciences, China Agricultural University, Beijing 100193, China Department of Pathology, Xingtai, P. R. China The State Key Laboratory of Natural and Biomimetic of Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, P. R. China Geneis (Beijing) Co., Ltd., Beijing, China; Qingdao Geneis Institute of Big Data Mining and Precision Medicine, Qingdao, China Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, China; College of Food Science and Engineering, Yangzhou University, Yangzhou 225009, China Institute of Atomic and Molecular Physics Jilin University Changchun 130012 P. R. China; Jilin Provincial Key Laboratory of Applied Atomic and Molecular Spectroscopy Jilin University Changchun 130012 P. R. China Department of Kidney Disease and Blood Purification, Institute of Urology & Key Laboratory of Tianjin, 2nd Affiliated Hospital of Tianjin Medical University, Tianjin - PR China College of Horticulture, Gansu Agricultural University, 1 Yinmen Village, Anning District Lanzhou, P.R. China Department of Cardiology, Henan Province Key Laboratory of Cardiac Injury and Repair The First Affiliated Hospital of Zhengzhou University Zhengzhou P. R. China Department of Spinal Surgery Peking University People's Hospital Beijing China Cold Spring Harbor Laboratory, Cold Spring Harbor, NY 11724, USA Biotechnology Research Institute of Shanghai Academy of Agricultural Sciences Shanghai Key Laboratory of Agricultural Genetics and Breeding Shanghai China; Key Laboratory for Safety Assessment (Environment) of Agricultural Genetically Modified Organisms Ministry of Agriculture and Rural Affairs Shanghai China Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, Beijing, People’s Republic of China; and; China National Clinical Research Center for Neurological Diseases, Beijing, People’s Republic of China Department of Gastroenterological Surgery Peking University People's Hospital Beijing China; Laboratory of Surgical Oncology Beijing Key Laboratory of Colorectal Cancer Diagnosis and Treatment Research Peking University People's Hospital Beijing China Geriatric Department, Geriatric Medical Center, Shanghai Ruijin Hospital Shanghai Jiao Tong University School of Medicine Shanghai China; International Laboratory in Cancer, Aging and Hematology Shanghai Jiao Tong University School of Medicine/Ruijin Hospital/CNRS/Inserm/Côte d'Azur University Shanghai China School of Life Sciences The Chinese University of Hong Kong Shatin, NT Hong Kong SAR P.R. China Institute of Functional Nano & Soft Materials (FUNSOM), Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, 199 Ren'ai Road, Suzhou, 215123, Jiangsu, China Department of Orthopedics Chinese PLA General Hospital Beijing, 100853 China Department of Neurosurgery Lanzhou University Second Hospital Lanzhou Gansu Province China Departments of Materials Science, ‡Chemistry, and §Physics, University of Illinois, Urbana, Illinois 61801, United States Department of Nephrology , Kidney Research Institute , West China Hospital of Sichuan University , Chengdu , , Sichuan Province , China Center for Translational Medicine, the First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi 710061, China Institute for Interdisciplinary Biomass Functional Materials Studies, Jilin Engineering Normal University, Changchun 130052, P.R. China Department of Epidemiology and Biostatistics, School of Public Health, Peking University, Beijing 100083, China. Department of Health Service Administration , , Shanghai 200433, China; Second Military Medical University , , Shanghai 200433, China Department of Hepatobiliary Surgery, The First Affiliated Hospital, School of Medicine, Shihezi University, Xinjiang, China Department of Anesthesiology, Wuhan Third Hospital, Tongren Hospital of Wuhan University, Wuhan, Hubei, China Inner Mongolia Medical University Hohhot China Vector Institute for Artificial Intelligence,Toronto,ON,Canada Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing 100094, P. R. China; Department of Animal Sciences, Washington State University, Pullman, WA 99164, USA Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing 210009, China Center for Medicinal Plant Research of the Arthur Temple College of Forestry and Department of Biology of the College of Sciences and Mathematics, Stephen F. Austin State University, Nacogdoches, Texas 75962 Department of Cardiac Surgery; Asia Heart Hospital; Wuhan P.R. China Beihang University School of Pharmacy, Nanjing University of Chinese Medicine, Nanjing 210023, China Department of Neurology Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, China Department of Clinical Laboratory The First Affiliated Hospital of Jinzhou Medical University Jinzhou Liaoning 121001 China Institute of Plant Protection, Jiangsu Academy of Agricultural Sciences, Nanjing 210014, P.R. China Tsinghua University; Key Laboratory of Photonic Control Technology (Tsinghua University) State Key Laboratory of Crop Stress Biology in Arid Areas and College of Plant Protection, Northwest A&F University, Yangling, Shaanxi Province, 712100, China College of Food Science and Technology, Bohai University, Jinzhou, Liaoning 121013, P.R. China MOE Key Laboratory of Bioinorganic and Synthetic Chemistry/KLGHEI of Environment and Energy Chemistry, School of Chemistry & Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, PR China Division of Genetics and Genomics, The Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom; Division of Infection and Immunity, The Roslin Institute, University of Edinburgh, Edinburgh, United Kingdom School of Life Science, Jiangsu Normal University, Xuzhou 221116, China Division of Nephrology, West China Hospital of Sichuan University, Chengdu, China Center for Multidimensional Carbon Materials (CMCM), Institute for Basic Science (IBS), Ulsan 44919, Republic of Korea Heilongjiang University of Chinese Medicine, Harbin, China Department of Oral Biology; Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling; School and Hospital of Stomatology; Jilin University; Changchun Department of Neurosurgery, Shenzhen Second People’s Hospital, Shenzhen University First Affiliated Hospital, Clinical College of Shantou University Medical College, Shenzhen, China Department of Materials Science and Engineering, ‡Department of Chemistry, and §Department of Physics, University of Illinois, Urbana, Illinois 61801, United States Jiangsu Key Laboratory for Carbon‐Based Functional Materials and Devices Institute of Functional Nano and Soft Materials (FUNSOM) Soochow University Suzhou 215123 China College of Chemistry, Fuzhou University, Fuzhou, Fujian 350108, China; State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China Department of Chemical Engineering; Imperial College London; UK Key Laboratory of Renewable Energy, Chinese Academy of Sciences, Guangzhou, China; School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing, China Department of Vascular Surgery, Shanghai Pudong Hospital, Fudan University Pudong Medical Center, Shanghai 201399, China; Fudan Zhangjiang Institute, Shanghai 201203, China; Shanghai Key Laboratory of Vascular Lesions Regulation and Remodeling, Shanghai, China State Key Laboratory of Protein and Plant Gene Research, School of Life Sciences, and Biomedical Pioneering Innovation Center (BIOPIC), Peking University , Beijing, 100871, China Beijing Key Laboratory of Photoelectronic/Electrophotonic Conversion Materials Key Laboratory of Cluster Science Ministry of Education School of Chemistry Beijing Institute of Technology Beijing 100081 P. R. China State Key Laboratory of Electroanalytical Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun 130022, Jilin, People’s Republic of China 1 Liaoning Engineering Research Center for Treatment and Recycling of Industrially Discharged Heavy Metals, Shenyang University of Chemical Technology, Shenyang 110142, China Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA Center for Reticular Chemistry at the California NanoSystems Institute, Department of Chemistry and Biochemistry, University of California, 607 Charles E. Young Drive East, Los Angeles, CA 90095 Laboratory of Lipid Biochemistry and Protein Interactions, Department of Cellular and Molecular Medicine KU Leuven Belgium Departments of Anesthesiology and Key Laboratory of Laboratory Medicine, Ministry of Education, Zhejiang Provincial Key Laboratory of Medical Genetics, Department of Cell Biology and Medical Genetics, College of Laboratory Medicine and Life sciences Wenzhou Medical University Wenzhou China Brown University, Department of Orthopaedic Surgery, Providence, RI, USA West China School of Public Health, Sichuan University, Chengdu 610041, China. Shanghai Engineering Research Center of Molecular Therapeutics & New Drug Development, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China Departments of †Chemistry and ‡Biochemistry and Molecular Biology and §The Huck Institutes of the Life Sciences, The Pennsylvania State University, University Park, Pennsylvania 16802, United States Key Lab of Quantum Sensing and Precision Measurement; North University of China Centre for Vascular Research, University of New South Wales, Sydney, New South Wales 2052, Australia. Department of Neurosurgery, Beijing Tiantan Hospital Affiliated to Capital Medical University, Beijing 100050, China. Department of Obstetrics and Gynecology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; National Clinical Research Center for Obstetrical and Gynecological Diseases, Wuhan, China Scientific Computing and Imaging Institute, University of Utah. Key Laboratory of Plant Molecular Physiology Institute of Botany Chinese Academy of Sciences Beijing China; University of Chinese Academy of Sciences Beijing China Zhengzhou University of Light Industry, Zhengzhou, China The State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100191, P. R. China Institute of Transfusion Medicine, Academy of Military Medical Sciences, 27 Taiping Road, Beijing 100850 School of Materials Engineering, Shanghai University of Engineering Science, Shanghai, 201620, China Key Laboratory of Applied Chemistry Yanshan University Qinhuangdao 066004 China School of Medicine & Holistic Integrative Medicine Nanjing University of Chinese Medicine Nanjing China UPMC Eye Center, Ophthalmology and Visual Science Research Center, Department of Ophthalmology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States 4Department of Bioengineering, Swanson School of Engineering, University Liaoning Provincial Key Laboratory of Oral Disease, School and Hospital of Stomatology China Medical University Shenyang City China State Key Laboratory of Brain and Cognitive Science, Beijing MRI Center for Brain Research, Institute of Biophysics Chinese Academy of Sciences Beijing China Xijing Hypertrophic Cardiomyopathy Center, Department of Ultrasound, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China College of Agriculture South China Agricultural University Guangzhou China Department of Immunology, Tianjin Institute of Immunology, Tianjin Key Laboratory of Cellular and Molecular Immunology, Key Laboratory of Diseases and Microenvironment of Ministry of Education of China, Tianjin Medical University, Tianjin 300070, P.R. China Department of Biomedical Sciences and Pathobiology, Virginia-Maryland College of Veterinary Medicine, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA; Center for Emerging, Zoonotic and Arthropod-borne Pathogens, Fralin Life Sciences Institute, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, USA Department of Cardiac Surgery Department of Gastrointestinal Surgery, The Third Affiliated Hospital of Hebei Medical University, Shijiazhuang, Hebei 050051, P.R. China Translational Research Institute and Department of Molecular Therapeutics, The Scripps Research Institute, Florida, 130 Scripps Way, 2A1, Jupiter, Florida 33458 Key Laboratory of Plant Molecular Physiology Institute of Botany Chinese Academy of Sciences Beijing 100093 China; University of Chinese Academy of Sciences Beijing 100049 China Engineering Research Center of Molecular-Imaging and Neuro-Imaging of Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an, Shaanxi 710026, China College of Forestry, Hebei Agricultural University, Baoding, China Division of Gastroenterology and Hepatology Key Laboratory of Gastroenterology and Hepatology Ministry of Health Renji Hospital School of Medicine Shanghai Jiao Tong University Shanghai Institute of Digestive Disease Shanghai China Department of Traditional Chinese Medicine Qilu Hospital of Shandong University Jinan China Department of Orthopaedics, First Affiliated Hospital of Dalian Medical University, Dalian; Key Laboratory of Molecular Mechanism for Repair and Remodeling of Orthopaedic Diseases, Liaoning Province State Key Laboratory of Chinese Medicine and Molecular Pharmacology; Shenzhen, China Key Laboratory of Zoological Systematics and Evolution, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China Laboratory of Stress Medicine, Department of Psychology and Mental Health, Second Military Medical University, Shanghai 200433, P.R. China State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China Department of Infectious Diseases, Robert Koch Institute, Berlin, Germany Department of Critical Care Medicine, West China Hospital, Sichuan University and Institute of Critical Care Medicine, Chengdu, Sichuan Province, China Department of Hematology, Hongqi Hospital Affiliated to Mudanjiang Medical University, Mudanjiang, Heilongjiang 157011, P.R. China Qingdao Engineering Research Center of Biomass Resources and Environment, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao 266101, China MOE Key Laboratory for Intelligent Networks & Network Security, Faculty of Electronic and Information Engineering, Xi’an Jiaotong University, Xi’an, China State Key Laboratory of Urban Water Resource and Environment; School of Chemical Engineering and Technology; Harbin Institute of Technology; Harbin; China MIIT Key Laboratory of Critical Materials Technology for New Energy Conversion and Storage School of Chemistry and Chemical Engineering Harbin Institute of Technology Harbin 150001 P. R. China Department of Chemistry and Supercomputing Institute, University of Minnesota, 207 Pleasant Street S.E., Minneapolis, Minnesota 55455-0431, United States CAS Key Laboratory of Colloid, Interface and Chemical Thermodynamics, Beijing National Laboratory for Molecular Sciences (BNLMS), CAS Research/Education Center for Excellence in Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, People’s Republic of China; School of Chemistry and Chemical Engineering, University of Chinese Academy of Sciences, Beijing 100049, People’s Republic of China Smart Materials Laboratory, Department of Applied Physics, Northwestern Polytechnical University, Xi’an, 710129, China Department of Pathology, The First Affiliated Hospital, Xinjiang Medical University, Urumqi, Xinjiang, China; Xinjiang Medical University, Urumqi, Xinjiang, China Key Laboratory of Crop Ecophysiology and Farming Systems in the Middle Reaches of the Yangtze River Ministry of Agriculture, College of Plant Science and Technology Huazhong Agricultural University Wuhan China School of Materials Science and Engineering Tianjin Chengjian University Tianjin 300384 P. R. China From the Cardiac Muscle Research Laboratory, Whitaker Cardiovascular Institute and Evans Department of Medicine, Boston University School of Medicine, Boston, Mass. Department of Microbiology; The University of Texas at Austin; Austin; 78712 USA Key Laboratory of Resources Green Conversion and Utilization of the State Ethnic Affairs Commission & Ministry of Education, South-Central University for Nationalities, Wuhan, Hubei 430073, China Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University; and Department of Thoracic Surgery, Nanjing Chest Hospital, School of Medicine, Southeast University, Nanjing, Jiangsu 210029, P.R. China Department of Joint Surgery Honghui Hospital Xi'an Jiaotong University Xi'an Shaanxi Province China |
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