http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_bd2b3180a6abd18113a087899eaad05c
Outgoing Links
Predicate | Object |
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family-name | Ling Chen Chen |
name | Ling. Chen Ling Chen |
given-name | Ling. Ling |
organization-name | School of Information Technology and Electrical Engineering, The University of Queensland, Brisbane, Australia Affiliated Hospital of Zunyi Medical College, Zunyi City, Guizhou Province, China. School of Pharmacy Nanjing University of Chinese Medicine Nanjing P. R. China; Shanghai Research Center for Modernization of Traditional Chinese Medicine National Engineering Laboratory for TCM Standardization Technology Shanghai Institute of Materia Medica Chinese Academy of Sciences Shanghai P. R. China State Key Laboratory of Respiratory Disease, National Clinical Research Centre for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China; Guangdong Laboratory of Computational Biomedicine, Guangdong-Hong Kong-Macau Joint Laboratory of Respiratory Infectious Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China; Guangzhou Laboratory, Guangzhou, People's Republic of China Department of Cardiology, Xinqiao Hospital, Army Medical University, Chongqing, China Ministry of Education Engineering Research Center of Starch & Protein Processing; Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety; College of Light Industry and Food Sciences; South China University of Technology; Guangzhou 510640 Endocrine & Metabolism Department, Peking University People’s Hospital, Beijing 100044, China Department of Obstetrics and Gynecology, Zhangjiagang Hospital of Traditional Chinese Medicine and Affiliated Zhangjiagang Hospital of Nanjing University of Chinese Medicine , Zhangjiagang 215600 , China Sanya Branch of Hainan Food and Drug Inspection Institute, Sanya 572011, China State Key Lab of Respiratory Disease, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China; Guangzhou 8th People’s Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China; Guangdong Laboratory of Computational Biomedicine, Chinese Academy of Sciences, Guangzhou Institutes of Biomedicine and Health, Guangzhou, People’s Republic of China State Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, People’s Republic of China; State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China State Key Laboratory of Agrobiotechnology and Key Laboratory of Pest Monitoring and Green Management-MOA, China Agricultural University, Beijing 100193, China Department of Otolaryngology‐Head and Neck, Sun Yat‐sen Memorial Hospital Sun Yat‐sen University Guang zhou China Center for Molecular Imaging and Nuclear Medicine School for Radiological and Interdisciplinary Sciences (RAD‐X) Soochow University Suzhou 215123 P. R. China; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Suzhou 215123 P. R. China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat‑Sen University, Guangzhou, Guangdong 510060, P.R. China Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, China School of Material Science and Engineering, University of Jinan, 250022, Jinan, China 1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Biochemistry and Molecular Biology, Peking University Cancer Hospital and Institute, Beijing, China. Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, United States; The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, and Chongqing Eye Institute, Chongqing, China Division of Biostatistics, Washington University School of Medicine, St. Louis Missouri, USA Department of Neurosurgery, Xuanwu Hospital, Capital Medical University, China International Neuroscience Institute, No. 45 Chuangchun Street, Beijing 100053, China. Department of Neurosurgery Chinese PLA General Hospital and PLA Medical College Beijing China School of Material Science & Engineering; University of Jinan; Jinan; P. R. China Laboratory of Reproductive Medicine, Department of Histology and Embryology, Nanjing Medical University, Nanjing 210029, China, and State Key Laboratory of Genetic Resources and Evolution, Kunming Institute of Zoology and Kunming Primate Research Center, Chinese Academy of Sciences, Kunming 650223, Yunnan, China Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Columbia University Irving Medical Center, New York Presbyterian Hospital, New York, NY 10032. Department of General Surgery, Xiangya Hospital Central South University Changsha China Affiliated Hospital of Zunyi Medical College, No. 149 Delian Road, Zunyi, Guizhou 563000, China School of Biotechnology and Health Sciences, Wuyi University, Jiangmen, Guangdong 529000, PR China College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China Department of Oncology, Changhai Hospital affiliated to Naval Military Medical University, Shanghai 200081, P.R. China State Key Laboratory of Reproductive Medicine, Department of Plastic and Cosmetic Surgery, Maternal and Child Health Medical Institute, Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University, Nanjing 210004, China Columbia University College of Physicians and Surgeons, New York, NY; Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, P. R. China Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, 410078, PR China Department of Physics, Wenzhou University, Wenzhou, Zhejiang 325035, China Department of Obstetrics and Gynecology, Columbia University, New York, NY, USA Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China. Institute of Materials Research and Engineering, 3 Research Link, Singapore 117602, Department of Chemistry, National University of Singapore, 3 Science Drive 3, Singapore 117543, Division of Johns Hopkins in Singapore, Singapore 138669, Singapore, and Department of Biomedical Engineering, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205 The First Department of Gynecology of Shanxi Provincial People’s Hospital, Taiyuan, 030012, Shanxi, China Department of Cardiothoracic Surgery Changhai Hospital Second Military Medical University Shanghai China School of Forensic Medicine, Southern Medical University, Guangzhou, PR China The Medical School, Ningbo University, Ningbo, China Vagelos College of Physicians and Surgeons, Columbia University, New York, New York; New York-Presbyterian Hospital, New York; Herbert Irving Comprehensive Cancer Center, New York, New York Bristol-Myers Squibb Research and Development, PO Box 4000, Princeton, New Jersey 08543-4000, United States Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou Science Park, Guangdong 510530, People’s Republic of China; State Key Laboratory of Respiratory Disease, Guangzhou, Guangdong 510120, People’s Republic of China Department of Nursing Shenzhen Hospital Southern Medical University Shenzhen Guangdong China; School of Nursing Southern Medical University Guangzhou Guangdong China Pulmonary and Critical Care Division, Long Island Jewish Medical Center, Long Island Campus for Albert Einstein College of Medicine, Hew Hyde Park 11042; and Ministry of Education Engineering Research Centre of Starch and Protein Processing, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou 510640, China [email protected] Department of Breast Pathology and Research, Tianjin Medical University Cancer Hospital, Tianjin 300060, China. Optimum Therapeutics, L. L. C., Ohio State University, Columbus, Ohio State Key Laboratory of Respiratory Disease, CAS Key Laboratory of Regenerative Biology, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Guangdong Provincial Key Laboratory of Biocomputing, Guangzhou Institutes of Biomedicine and Health; State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou Laboratory, Guangzhou International Bio Island, Guangzhou, China Department of Nursing, Shenzhen hospital, Southern Medical University, Shenzhen, Guangdong, China National Biopesticide Engineering Technology Research Center, Hubei Biopesticide Engineering Research Center, Hubei Academy of Agricultural Sciences, Biopesticide Branch of Hubei Innovation Centre of Agricultural Science and Technology, Wuhan 430064, PR China Department of Pathology, Tianjin Central Hospital of Obstetrics and Gynecology, Tianjin, China National Stem Cell Resource Center Institute of Zoology, Chinese Academy of Sciences Beijing China; University of Chinese Academy of Sciences Beijing China; Savaid Medical School University of Chinese Academy of Sciences Beijing China Active Carbohydrate Research Center, College of Chemistry, Chongqing Normal University, Chongqing, 401331, China School of Chemical Engineering and Advanced Materials The University of Adelaide Adelaide 5005 Australia School of Material Science and Engineering; University of Jinan; Jinan; P. R. China Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Xiangya Hospital, Central South University, Changsha, Hunan, China; Cancer Research Institute, Central South University, Changsha, Hunan, China MOE Laboratory of Bioinorganic and Synthetic Chemistry State Key Laboratory of Optoelectronic Materials and Technologies Lehn Institute of Functional Materials School of Chemistry and Chemical Engineering Sun Yat-Sen University Guangzhou 510275 China Laboratory of Reproductive Medicine, Department of Physiology, Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China Department of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, P.R. China Department of Nursing, Shenzhen Hospital Southern Medical University Shenzhen China; School of Nursing Southern Medical University Guangzhou Guangdong China From the Wilmot Cancer Center, University of Rochester, Rochester, NY; Georgetown University Hospital, Washington, DC; Cephalon Inc, Frazer, PA; QE II Health Sciences Centre, Halifax, Nova Scotia; Ottawa Hospital, Ottawa, Ontario, Canada; University of Alabama, Birmingham, AL; Dana-Farber Cancer Institute, Boston, MA; The University of Texas M.D. Anderson Cancer Center, Houston, TX; San Diego Cancer Center, San Diego; Desert Regional Med Center, Palm Springs, CA; and University of Virginia,... Department of Plastic & Cosmetic Surgery, Women's Hospital of Nanjing Medical University (Nanjing Maternity and Child Health Care Hospital), 123rd Tianfei Street, Mochou Road, Nanjing 210004, China Department of Thoracic Surgery, Changhai Hospital, Naval Medical University, Shanghai 200433, P.R. China Department of Pathology Tianjin Central Hospital of Gynecology Obstetrics Tianjin People's Republic of China College of Chemistry and Chemical Engineering, Key Laboratory of Functional Small Organic Molecule of Ministry of Education, Jiangxi Normal University, Nanchang, Jiangxi 330022, P. R. China Department of Physiology Nanjing Medical University Nanjing China; State Key Laboratory of Reproductive Medicine Nanjing Medical University Nanjing China Institute of Clinical Immunology, Union Hospital of Fujian Medical University, Fuzhou 350001, China. [email protected] Department of Neuroscience Chemistry, Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, Connecticut 06492, United States b Laboratory of Medicinal Chemistry, NIDDK, National Institutes of Health , Bethesda , MD , 20892 , U.S.A. Department of Neurology, Wenzhou Municipal Hospital of Traditional Chinese Medicine, Wenzhou, China Department of Pathology, Tianjin Central Hospital of Gynecology Obstetrics, Gynecology Obstetrics Hospital of Nankai University Tianjin, China. Department of Pharmacy, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, China College of Animal Science and Technology Northwest A&F University; Shaanxi Key Laboratory of Agricultural Molecular Biology Yangling Shaanxi 712100 China State Key Laboratory of Respiratory Disease, Center for Infection and Immunity, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences Department of Communication Studies, Hong Kong Baptist University, Hong Kong SAR, China State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Nanjing University, Nanjing 210023, China Department of Plastic & Cosmetic Surgery Women’s Hospital of Nanjing Medical University (Nanjing Maternity and Child Health Care Hospital) Nanjing China Washington University in St. Louis, St. Louis, MO, USA Division of Biostatistics Washington University in St. Louis School of Medicine St. Louis Missouri USA Department of Infectious Diseases, The Second Affiliated Hospital of Nanchang University, School of Pharmaceutical Science, Nanchang University, Nanchang PR China State Grid Sichuan Electric Power Research Institute 3 , Chengdu 610000, China Department of Ultrasound Imaging Guangdong Province Hospital of Chinese Medicine Guangdong China Key Laboratory of Cognitive Science, Laboratory of Membrane Ion Channels and Medicine, Hubei Key Laboratory of Medical Information Analysis and Tumor Diagnosis and Treatment, College of Biomedical Engineering South‐Central Minzu University Wuhan China Department of Plastic & Cosmetic Surgery Maternal and Child Health Medical Institute The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University Nanjing Maternity and Child Health Care Hospital Nanjing China Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Food Science and Technology, Jiangnan University, Wuxi 214122, P. R. China Department of Neurology, Neurological Intensive Care Unit, The First Affiliated Hospital, Sun Yat-Sen University; Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases; National Key Clinical Department and Key Discipline of Neurology , No. 58 Zhongshan 2nd Road , Guangzhou , 510080 , China Department of Nursing, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong, 518101, P.R. China Department of Natural Medicine; School of Pharmacy; Fudan University; Shanghai 201203; China State Key Laboratory of Respiratory DiseaseThe First Affiliated Hospital of Guangzhou Medical University Guangzhou China; Guangzhou Institutes of Biomedicine and HealthChinese Academy of Sciences Guangzhou China Bioengineering & Biomaterials Micro‐CT and Imaging Facility University of California, San Francisco San Francisco CA USA State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, 155 Yangqiao Road West, Fuzhou, Fujian 350002, People’s Republic of China Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of Education Hubei Key Laboratory of Material Chemistry and Service Failure Hubei Engineering Research Center for Biomaterials and Medical Protective Materials Semiconductor Chemistry Center School of Chemistry and Chemical Engineering Huazhong University of Science and Technology Wuhan 430074 P. R. China Beijing National Laboratory for Molecular Sciences; CAS Research/Education Center for Excellence in Molecular Sciences; National Centre for Mass Spectrometry in Beijing; CAS Key Laboratory of Analytical Chemistry for Living Biosystems; Institute of Chemistry Chemical Development and Drug Product Science and Technology, Bristol-Myers Squibb Company, One Squibb Drive, New Brunswick, New Jersey 08903, United States, and Molecular Sciences and Candidate Optimization, Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, Connecticut 06492, United States Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P. R. China Ministry of Education Engineering Research Center of Starch and Protein Processing, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China Division of Pathology Xijing Hospital of Digestive Diseases Fourth Military Medical University Xi'an China The Second Department of Respiratory Medicine (Center for Evidence-Based and Translational Medicine of Major Infectious Diseases), Affiliated Hospital of Zunyi Medical College, Zunyi, China. Teva Biometrics Operations, Malvern, PA Department of Internal Medicine‐Oncology Affiliated Hospital of Shandong Academy of Medical Sciences Shandong First Medical University Jinan China Departments of Viral Vaccine Research Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Affiliated to Shanghai University of Traditional Chinese Medicine (TCM), Shanghai, China. Engineering Research Center for Nanophotonics & Advanced Instrument, Ministry of Education, School of Physics and Electronics Science, East China Normal University, 500 Dongchuan Road, 201100 Shanghai, China Center for Diabetes Research and Gifford Laboratories, University of Texas Southwestern Medical Center Dallas Department of Veterans Affairs Medical Center Dallas Texas Institute of Histology and Embryology, Center Medical Universitaire Geneva, Switzerland Department of Internal Medicine, Tohoku University, School of Medicine Sendai, Japan Department of Neurology The First Affiliated Hospital of Sun Yat‐sen University Guangzhou China Department of Respiratory and Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou, China Department of Endocrinology and Metabolism, Peking University People’s Hospital, Peking University Diabetes Center, Beijing, 100044, China Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education, Hubei Key Laboratory of Material Chemistry and Service Failure, Hubei Engineering Research Center for Biomaterials and Medical Protective Materials, Semiconductor Chemistry Center, School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Ministry of Education, Wuhan 430074, China Department of Oncology, The Second Clinical College of North Sichuan Medical College, Nanchong Central Hospital, Nanchong, Sichuan, China Department of Respiration, No. 305 Hospital of PLA, Beijing, China Ultrasonography Department, The First Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China Department of Pathology and Laboratory Medicine, David Geffen School of Medicine at University of California Los Angeles, Los Angeles, California Key Laboratory of Synthetic Biology Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences 300 Fenglin Road Shanghai 200032 China School of Materials Science and Engineering University of Jinan Jinan 250022 China Shenzhen Eye Hospital, Shenzhen Key Laboratory of Ophthalmology, Affiliated Shenzhen Eye Hospital of Jinan University Shenzhen, P. R. China. Laboratory of Immunotherapy, Sun Yet-Sen University, Guangzhou, GD, People’s Republic Of China; Institute of Immunotherapy, Fujian Medical University, Fuzhou, FJ, People’s Republic Of China Department of Oncology, The Second Clinical College of North Sichuan Medical College Nanchong Central Hospital Nanchong Sichuan China Pulmonary and Critical Care Division, Long Island Jewish Medical Center, Long Island Campus for the Albert Einstein College of Medicine, New Hyde Park, New York 11042 Center for Infection & Immunity, Guangzhou Institute of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, China.; College of Life Science, University of Science and Technology of China (USTC), Hefei, China. Key Laboratory of Functional Small Organic Molecules Ministry of Education and College of Chemistry and Chemical Engineering Jiangxi Normal University Nanchang 330022 PR China Tianjin Key Laboratory of the Design and Intelligent Control of the Advanced Mechatronical System, Tianjin, China; School of Mechanical Engineering, Tianjin University of Technology, Tianjin 300384, China Department of Physiology University of Maryland School of Medicine Baltimore MD 21201 USA; Department of Medicine University of Maryland School of Medicine Baltimore MD 21201 USA Department of Epidemiology and Biostatistics, Memorial Sloan Kettering Cancer Center, New York, New York Key Laboratory of Crop Genetics and Breeding of Hebei Province, Institute of Cereal and Oil Crops, Hebei Academy of Agriculture and Forestry Sciences, Shijiazhuang 050035, China Departments of Pathology, the Nanjing Drum Tower Hospital, Nanjing, China The Second Affiliated Hospital of Nanchang University Nanchang University Nanchang China; State Key Laboratory of Food Science and Technology Nanchang University Nanchang China Division of Cardiac Surgery University of Maryland School of Medicine, Baltimore, Maryland, USA Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO 63110, USA Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, People’s Republic of China Shanghai Engineering Research Center of Hierarchical Nanomaterials School of Chemical Engineering East China University of Science and Technology Shanghai 200237 China MOE Laboratory of Bioinorganic and Synthetic Chemistry; State Key Laboratory of Optoelectronic Materials and Technologies; School of Chemistry and Chemical Engineering; Sun Yat-Sen University; Guangzhou 510275 Institute of TCM and Natural Products; School of Pharmaceutical Sciences; Wuhan University; Wuhan 430071; P.R. China Institute and Department of Endocrinology Shanghai Jiaotong University of medicine Affiliated to Ruijin Hospital Luwan Branch Shanghai China Department of Neurosurgery, Chinese PLA General Hospital, Beijing, 100853, China. Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials Ministry‐of‐Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules, College of Chemistry and Chemical Engineering Hubei University Wuhan P. R. China Sunshine Dental Clinic of Hangzhou City; Pulmonary and Critical Care Division, Long Island Jewish Medical Center, Long Island Campus for the Albert Einstein College of Medicine, Hew Hyde Park, New York 11042 Early Life Institute and Department of Geology, Northwest University, Xi'an 710069, China, and School of Earth Sciences and Resources, China University of Geosciences, Beijing 100083, China. Department of Chemistry, Iowa State University, Ames, Iowa 50011, and Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China Physiology University of Maryland School of Medicine Baltimore MD USA Department of Clinical Pharmacy, Hangzhou First People's Hospital, Nanjing Medical University, Hangzhou, Zhejiang Province, China School of Pharmaceutical Science, Nanchang University, Nanchang, Jiangxi, China Neurology, The First Affiliated Hospital of Sun Yat-Sen University; and Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases, National Key Clinical Department and Key Discipline of Neurology, Guangzhou School of Liquor and Food Engineering, Guizhou University, Guiyang 550025, China From the Department of Pathology and Immunology (Drs Pittman, Treese, Frater, Nguyen, Hassan, and Kreisel) and the Division of Biostatistics (Dr Chen), Washington University School of Medicine, Saint Louis, Missouri. Shanghai Kangshi Food Technology Co., Ltd. No. 1978 Lianhua Rd. Shanghai 201103 China College of Engineering and Design, Hunan Normal University, Changsha 410081, China Biotechnology and Germplasm Resources Institute, Yunnan Academy of Agricultural Sciences, Yunnan Provincial Key Lab of Agricultural Biotechnology, Key Lab of Southwestern Crop Gene Resources and Germplasm Innovation, Ministry of Agriculture, Kunming, Yunnan 650205, P.R. China Department of Acupuncture and Moxibustion, The Second Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou, China; Second Clinical College, Guangzhou University of Chinese Medicine, Guangzhou, China Department of Respiratory Medicine, Affiliated Hospital of Zunyi Medical University, Zunyi School of Materials Science and Engineering, University of Jinan, Jinan 250022, China Department of Pharmacy, Wuhan Third Hospital (Tongren Hospital of Wuhan University) Wuhan 430060, China. Key Laboratory of Synthetic Biology Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences Shanghai 200032 China The Eye and ENT Hospital of Fudan University Shanghai China Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts; Programs in Metabolism and Medical & Population Genetics, Broad Institute of Harvard & Massachusetts Institute of Technology, Cambridge, Massachusetts Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA. Department of Respiratory and Critical Care Medicine, Nanjing Drum Tower Hospital, Clinical College of Nanjing Medical University, Nanjing, Jiangsu, China Department of Geriatric Cardiology, The First Affiliated Hospital, China Medical University, Shenyang, China State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, People’s Republic of China, and State Key Laboratory of Metastable Materials Science and Technology, Yanshan University, Qinhuangdao 066004, People’s Republic of China State Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, People’s Republic of China; State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China; Guangzhou Laboratory & Bioland Laboratory, Guangzhou, People’s Republic of China State Key Laboratory of Quality Research in Chinese Medicine Institute of Chinese Medical Sciences University of Macau Taipa Macau SAR 999078 P. R. China Department of Social Medicine and Health Management, Xiangya School of Public Health, Central South University Department of Neonatology, TongJi Hospital, Tongji Medical College, P. R. China Divisions of Biostatistics, Washington University School of Medicine, St Louis, MO. Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education Xiangya Hospital, Central South University Hunan China; Key Laboratory of Carcinogenesis, Ministry of Health Cancer Research Institute, Central South University Hunan China Evidence-Based Medicine Center, MOE Virtual Research Center of Evidence-Based Medicine at Zunyi Medical College, Affiliated Hospital of Zunyi Medical College, Zunyi, 563000 Guizhou, China; Department of Respiratory Medicine (Center for Evidence-Based and Translational Medicine of Major Infectious Diseases), Affiliated Hospital of Zunyi Medical College, Zunyi, 563000 Guizhou, China Department of Pathology Longhua HospitalShanghai University of Traditional Chinese Medicine Shanghai China University of Science and Technology of China, China; Anhui Medical University, China Nanjing Maternity and Child Health Care Institute Nanjing Maternity and Child Health Care Hospital Obsterics and Gynecology Hospital Affiliated to Nanjing Medical University Nanjing 210004 China Center for Human Genetic Research and Diabetes Research Center (Diabetes Unit), Massachusetts General Hospital, Boston, MA, USA. Department of Geratic Medicine, First Affiliated Hospital of China Medical University Shenyang, Liaoning, P.R. China. Department of Pathology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, China, 210008 Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing, China. Ningbo Marine Environmental Monitoring Centre, State Oceanic Administration, Ningbo 315012, Zhejiang, China. Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China. Department of Geriatrics, The First Affiliated Hospital of China Medical University, Shenyang 110001, Liaoning Province, China. Department of Dermatology Daping Hospital Third Military Medical University Chongqing China School of Chemistry and Chemical Engineering, Southeast University, Jiangsu Province Hi-Tech Key Laboratory for Biomedical Research Jiangnan, Nanjing, Jiangsu 211189, P. R. China Key Laboratory for Special Functional Materials, Collaborative Innovation Center of Nano Functional Materials and Applications, Henan University, Kaifeng 475004, P. R. China Henan Key Laboratory of Chemical Biology and Organic Chemistry; Key Laboratory of Applied Chemistry of Henan Universities; Zhengzhou University; Zhengzhou; P.R. China Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, China; State Key Laboratory of Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, People’s Republic of China College of Pharmaceutical Sciences; Jiangsu University; Zhenjiang; China Department of Nursing, The Fourth Hospital of Hebei Medical University, Shijiazhuang 050011, Hebei, China School of Material Science and Engineering, University of Jinan, 250022, Jinan, P. R. China Department of Dermatology, Institute of Battle Surgery, Daping Hospital, Third Military Medical University, Chongqing, China. Departments of Ultrasound, Second Affiliated Hospital, Guangzhou University of Traditional Chinese Medicine, Guangzhou 510120, China Department of Neurology The Affiliated Hospital of Zunyi Medical University Zunyi China Department of Medical Oncology, Fujian Cancer Hospital & Fujian Medical University Cancer Hospital, Fuzhou, Fujian, China From the Ocular Inflammatory Disease Center, Jules Stein Eye Institute and the2Departments of Ophthalmology and3Pharmacology, David Geffen School of Medicine at the University of California, Los Angeles, California; the Department of Dermatology, Daping Hospital, Third Military Medical University, Chongqing, China. College of Pharmacy, Sookmyung Women’s University Institute of Advanced Materials School of Chemistry and Chemical Engineering Jiangsu Province Hi-Tech Key Laboratory for Bio-medical Research Southeast University Nanjing 211189 China Wuxi School of Medicine Jiangnan University Wuxi China Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons , New York, NY, USA 1Institute of Gastroenterology, Southwest Hospital, Department of Infectious Diseases, Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases, The Second Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China Department of Clinical Pharmacy, Hangzhou First People's Hospital, Hangzhou, Zhejiang Province, China Department of Medical Ultrasound The First Affiliated Hospital of Fujian Medical University Fuzhou China Department of Thyroid and Breast Surgery The First Affiliated Hospital of FuJian Medical University FuZhou FuJian Province People's Republic of China Key Laboratory of Optoelectronic Materials Chemistry and Physics; Fujian Institute of Research on the Structure of Matter; Chinese Academy of Sciences; Fuzhou; People's Republic of China School of Biotechnology and Health Science; Wuyi University; Jiangmen 529000; P. R. China School of Materials Science and Engineering; Fujian University of Technology; Fuzhou 350108; PR China Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China. Guangzhou Institute of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, China.; State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, Guangzhou Medical College, Guangzhou, China. Department of Nursing, College of Medicine and Health Science, Wuhan Polytechnic University, Wuhan, Hubei, China College of Physicians and Surgeons, Columbia University, New York, New York, USA Divisions of Pulmonary and Critical Care Medicine and Cardiology, Department of Medicine, University of Maryland, Baltimore, Maryland State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Department of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Fudan University, Shanghai 200433, People’s Republic of China; Laboratory of Advanced Materials, Fudan University, Shanghai 200433, People’s Republic of China Department of Obstetrics and Gynecology, the Affiliated Hospital of Jiangnan University, Wuxi, China Key Laboratory of Optoelectronic Materials Chemistry and Physics, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, P. R. China, and Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350002, P. R. China Department of Medicine, Clinical and Translational Epidemiology Unit, Mongan Institute, Massachusetts General Hospital , Boston, MA 02114, United States; Metabolism Program, Broad Institute of MIT and Harvard , Cambridge, MA 02142, United States Medicine, University of Maryland School of Medicine, Baltimore, Maryland; for the Reduction of Infection in Neonatal Intensive Care Units Using the Evidence-Based Practice for Improving Quality (REIN-EPIQ) Study Group Center of Experimental Teaching Management, Chongqing Medical University, Chongqing 400016, China. [email protected]. Department of Dermatology, Institute of Battle Surgery, Daping Hospital, Third Military Medical University, Chongqing 400042, China. Laboratory of Jiangyou People's Hospital; Sichuan China Department of Endocrinology Fujian Provincial Hospital Key Laboratory of Endocrinology Fujian Medical University Fuzhou China Department of Infectious Disease, Zhejiang Hospital, Hangzhou, Zhejiang 310012, P.R. China Department of Endocrinology, Shengli Clinical Medical College of Fujian Medical University, Fujian Provincial Hospital, Fuzhou, China Department of Pathology, Nanjing Drum Tower Hospital Affiliated Hospital of Nanjing University Medical School Nanjing P.R. China Guangdong Provincial People's Hospital, Guangdong Academy of Medical Sciences, Guangzhou, China Department of Ophthalmology & Vision Science, Eye & ENT Hospital, Shanghai Medical School, Fudan University, Shanghai, China; Key NHC Key Laboratory of Myopia (Fudan University), Laboratory of Myopia, Chinese Academy of Medical Sciences, Shanghai, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Eye & ENT Hospital, Shanghai Medical School, Fudan University, Shanghai, China State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China; State Key Laboratory of Respiratory Disease Guangzhou Institutes of Biomedicine and Health, Guangzhou, Guangdong, China Departments of Endocrinology and Metabolism, Peking University People’s Hospital, Peking University Diabetes Center, Beijing 100044, China Cangzhou Medical College Cangzhou 061001, China. Department of Dermatology, Institute of Battle Surgery, Daping Hospital, Third Military Medical University, Chongqing, China Department of Infectious Diseases, Affiliated Jinhua Hospital, Zhejiang University School of Medicine , Jinhua , China Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China Guangzhou Institute of Biomedicine and Health, Guangzhou, China 510663. Department of Physiology, Ningxia Medical University, Yinchuan, Ningxia 750004, P.R. China Department of Human Genetics, Merck Research Laboratories Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, New York Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, People’s Republic of China; Guangzhou Laboratory, Guangzhou, People’s Republic of China College of Hydraulic & Environmental Engineering, Engineering Research Center of Eco-environment in Three Gorges Reservoir Region, Ministry of Education, China Three Gorges University, Yichang 443002, China. [email protected] Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York. Department of Breast Cancer Pathology and Research Laboratory, State Key Laboratory of Breast Cancer Research, Cancer Hospital of Tianjin Medical University, Tianjin, China Ministry of Education Engineering Research Center of Starch & Protein Processing; Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety; School of Food Science and Engineering; South China University of Technology; Guangzhou Department of Nephrology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, Sichuan, China Department of Natural Medicine, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, China Bristol-Myers Squibb Research & Development, Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, Connecticut 06492, United States State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, People’s Republic of China Terry Fox Laboratory, British Columbia Cancer Agency, Vancouver, British Columbia, Canada; Division of Biostatistics (J.H., L.C.), Washington University School of Medicine, St. Louis, MO Department of Obstetrics and Gynecology, Columbia University Irving Medical Center–New York Presbyterian Hospital, New York, New York, USA State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology, Huazhong Agricultural University, Wuhan, Hubei, China Key Laboratory of Special Energy Materials Ministry of Education, School of Chemistry and Chemical Engineering, Nanjing University of Science and Technology, Nanjing, Jiangsu 210094, China Department of Emergency Critical Care Medicine, The First Hospital of Lanzhou University, Lanzhou, Gansu 730000, P.R. China The Second Affiliated Hospital of Nanchang University, Nanchang University Nanchang China; State Key Laboratory of Food Science and Technology Nanchang University Nanchang China Intervention and Cell Therapy Center, Peking University Shenzhen Hospital, Shenzhen, China The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, and Chongqing Eye Institute, Chongqing, China; Department of Ophthalmology and Visual Sciences, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama, United States Department of Oncology, Changhai Hospital, Naval Medical University Shanghai, People's Republic of China. Exercise Physiology Program, University of Louisville, Louisville, Kentucky; Department of Cardiology, Affiliated Hospital of North Sichuan Medical College Key Laboratory of Food Nutrition and Safety; Ministry of Education; College of Food Science and Biotechnology; Tianjin University of Science and Technology; Tianjin 300457 From the Division of Cardiology (D.B.F., A.S.H., J.R., L.C., A.S., B.O'R.) and the Department of Biomedical Engineering (A.S.H.), The Johns Hopkins University School of Medicine, Baltimore, MD; and the Department of Biology, Portland State University, Portland, OR (A.O.G., K.D.G.). Evidence-Based Medicine Center, MOE Virtual Research Center of Evidence-Based Medicine at Zunyi Medical College, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, Guizhou, China; Department of Respiratory Medicine (Center for Evidence-Based and Translational Medicine of Major Infectious Diseases), Affiliated Hospital of Zunyi Medical College, Zunyi 563003, Guizhou, China Department of Plant Pathology Nanjing Agricultural University Nanjing 210095 China Department of Pharmacy, Wuhan Third Hospital (Tongren Hospital of Wuhan University), Wuhan, Hubei, China State Key Laboratory of Food Science and Resources Jiangnan University Wuxi China; Science Center for Future Foods Jiangnan University Wuxi China; School of Food Science and Technology Jiangnan University Wuxi China; International Joint Laboratory on Food Safety Jiangnan University Wuxi China; Jiaxing Institute of Future Food Jiaxing China State Key Laboratory of Pollution Control and Resources Reuse, Tongji University, Shanghai 200092, China. Teva Branded Pharmaceutical Products R&D, Inc., Frazer, PA; and Shanghai Engineering Research Center of Hierarchical Nanomaterials, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China The Medical School, Ningbo University, Ningbo, China 315211 State Key Laboratory of Biocatalysis and Enzyme Engineering, School of Life Sciences, Hubei Collaborative Innovation Center for Green Transformation of Bio-resources, Hubei University, Wuhan, PR China Department of Obstetrics and Gynecology, First Affiliated Hospital of Shihezi University, Shihezi, Xinjiang 832001, P.R. China Shanghai Putuo Mental Health Center, Shanghai, China The Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China Department of Otolaryngology‐Head and Neck Sun Yat‐sen Memorial Hospital, Sun Yat‐sen University Guangzhou China Washington University School of Medicine; St Louis University Health Sciences Center; Department of Veterans Affairs Medical Center, St Louis MO; and American Cancer Society, Atlanta GA Cell Therapy Center, Beijing Institute of Geriatrics, Xuanwu Hospital, Capital Medical University, Beijing 100053, People’s Republic of China State Key Laboratory of Pollution Control and Resources Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China Eye and Ears, Nose, and Throat Hospital, Department of Ophthalmology, Fudan University, Shanghai, China. Department of Endocrinology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu Province, P.R. China Guangzhou Women and Children’s Medical Center, Guangzhou Medical College, 318 Renminzhong Road, Guangzhou 510120, People’s Republic of China. Columbia University College of Physicians and Surgeons , New York, NY, USA Institute of TCM and Natural Products, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China; Department of Biochemistry and Molecular Biology, The School of Basic Medical Sciences, Fujian Medical University, Fuzhou, Fujian 350108, P.R. China 1Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA; 3Programs in Metabolism and Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, MA Ophthalmological and Stomatological Department of Yongkang First People's Hospital.Yongkang 321300, Zhejiang Province, China. Diabetes Research Center (Diabetes Unit), Department of Medicine, Massachusetts General Hospital Department of Basic Medical Science, School of Medicine, Xiamen University, Xiamen 361102, China; Key Laboratory of Chiral Drugs, Xiamen 361102, China Department of Endocrinology and Metabolism Peking University People's Hospital Peking University Diabetes Center Beijing China Department of Geriatric Medicine, First Affiliated Hospital of China Medical University Shenyang, Liaoning, P.R. China. State Key Laboratory of Agricultural Microbiology, College of Life Science and Technology Huazhong Agricultural University Wuhan China Department of Pediatrics Shanghai Sixth People's Hospital Affiliated to Shanghai Jiaotong University Shanghai 200233 People's Republic of China Juancheng Daya Town Agricultural Comprehensive Service Center, Heze 274612, Shandong, China. Bristol-Myers Squibb Research & Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States Department of Neurology Guangdong Provincial Key Laboratory of Diagnosis and Treatment of Major Neurological Diseases National Key Clinical Department and Key Discipline of Neurology The First Affiliated Hospital, Sun Yat‐sen University Guangzhou China State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, People's Republic of China, and Graduate School of the Chinese Academy of Sciences, Beijing 100039, People's Republic of China Department of Nephrology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China Chinese PLA Institute of Neurosurgery Chinese PLA General Hospital and PLA Medical College Beijing China [email protected] Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming 650500, China State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, People’s Republic of China Department of Pharmaceutics, School of Pharmaceutical Science, Nanchang University, Nanchang 330006, PR China Department of Neurology, First Affiliated Hospital Sun Yat‐sen University Guangzhou Guangdong China Key Laboratory of Molecular Biology of Infectious Diseases, Ministry of Education, Chongqing Medical University, Yuzhong, Chongqing 400016, P.R. China Department of Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06492 Department of Geriatric Medicine, First Affiliated Hospital of China Medical University Shenyang, Liaoning, P. R. China. Division of Biostatistics, Washington University School of Medicine, St. Louis, MO, USA; Department of Pathology, The Affiliated Drum Tower Hospital of Nanjing University Medical School, Nanjing, Jiangsu 210008, P.R. China From the Department of Cardiovascular Medicine (M.K., K.E., T.I., J.K., L.C., K.N., T.K., K. Sunagawa), Surgery (S.O., R.T.), and Pathology (K. Sueishi), Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan; the School of Pharmaceutical Science (Y.K.), Aichi Gakuin University, Aichi, Japan; and Hosokawa Powder Technology Research Institute (K.H., H.T.), Osaka, Japan. Department of Neurosciences Chemistry, Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, Connecticut 06443 [email protected] Cancer Research Institute, Central South University, Changsha, Hunan, 410078, China; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Hunan, 410078, China; Key Laboratory of Carcinogenesis, National Health and Family Planning Commission, Hunan, 410078, China College of Chemistry and Chemical Engineering and Key Laboratory of Functional Small Organic Molecules, Ministry of Education, Jiangxi Normal University (Yaohu Campus), 99 Ziyangdadao Avenue, Nanchang, Jiangxi 330022, China Division of Biostatistics, Washington University School of Medicine College of Pharmacy, Sookmyung Women's University, Seoul, Republic of Korea. Department of Respiratory Medicine, Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou, China. Institute of Crop Germplasm Resources, Shanxi Academy of Agricultual Sciences, Taiyuan, Shanxi, China;; Key Laboratory of Crop Gene Resources and Germplasm Enhancement on Loess Plateau, Ministry of Agriculture, Taiyuan, Shanxi, China;; Shanxi Key Laboratory of Genetic Resources and Genetic Improvement of Minor Crops, Taiyuan, Shanxi, China; School of Pharmaceutical Science, Nanchang University, Nanchang, PR China Department of Otolaryngology-HNS, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, 107 Yanjiang West Rd, Guangzhou 510120, China Xinzhuang Community Health Service Center, Shanghai, China School of Biomedical Sciences and Pharmacy University of Newcastle Newcastle NSW Australia Key Laboratory of Imaging Diagnosis and Minimally Invasive Intervention Research Clinical College of The Affiliated Central Hospital, Lishui University Lishui China; Institute of Imaging Diagnosis and Minimally Invasive Intervention Research The Fifth Affiliated Hospital of Wenzhou Medical University Lishui China Department of Otolaryngology-Head and Neck, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, China Key Laboratory of Material Chemistry for Energy Conversion and Storage Ministry of Education Hubei Key Laboratory of Material Chemistry and Service Failure Hubei Engineering Research Center for Biomaterials and Medical Protective Materials Semiconductor Chemistry Center School of Chemistry and Chemical Engineering Huazhong University of Science and Technology Wuhan 430074 China Medicine, University of Maryland School of Medicine, Baltimore, Maryland Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education Hangzhou Normal University No. 2318, Yuhangtang Road Hangzhou 311121 P. R. China Department of Infectious Diseases, Zhejiang Hospital, Hangzhou, China Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, People's Republic of China. Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, NY, USA, Department of Thoracic Surgery, Changhai Hospital, Shanghai 200433, P.R. China From the Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, MA; and the Department of Haematology, Singapore General Hospital, Singapore. Department of Thyroid and Breast Surgery The First Affiliated Hospital of Fujian Medical University Fuzhou Fujian China Department of Cardiac Surgery; Second Hospital Affiliated to Shandong University; Jinan Shandong China Division of Biostatistics, Washington University in St. Louis School of Medicine, St. Louis , Missouri, USA the Second Clinical College of Shanxi Medical University, Taiyuan 030001, China. Department of Ophthalmology and Visual Sciences, School of Medicine, University of Alabama at Birmingham, Birmingham; The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, and Chongqing Eye Institute, Chongqing, China State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan 430070, People's Republic of China Division of Biostatistics, Washington University, St. Louis, Missouri Department of Pathology, Tianjin Central Hospital of Gynecology Obstetrics Tianjin, People's Republic of China. Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235 Department of Plastic and Cosmetic Surgery Maternal and Child Health Medical Institute The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital Nanjing China Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China. Email: [email protected]. From the Departments of Surgery (S.K., R.T.), Cardiovascular Medicine (K.E., L.C., K.N., E.I., M.M., K. Sunagawa), and Pathology (K. Sueishi), Graduate School of Medical Science, Kyushu University, Fukuoka; Hosokawa Powder Technology Research Institute (H.T., K.H.), Osaka; and Division of Clinical Gene Therapy (R.M.), Osaka University Medical School, Osaka, Japan. Department of Forensic Biology, School of Forensic Medicine, Southern Medical University, Guangzhou, Guangdong, China Key Laboratory of Applied Surface and Colloid Chemistry (Ministry of Education), School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710119, People’s Republic of China Department of Infectious Disease, Zhejiang Hospital, Hangzhou, China Division of Biostatistics, Department of Medicine, Washington University School of Medicine, St. Louis, MO. Department of Rehabilitation Medicine, Zhujiang Hospital, Southern Medical University, Guangzhou 510280, China Bristol-Myers Squibb Research & Development, Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, Connecticut 06443, United States State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, 163 Xianlin Avenue, Nanjing, Jiangsu 210023, P.R. China The First Affiliated Hospital, Department of Endocrinology and Metabolism, Hengyang Medical School University of South China Hengyang 421001 China Institute of Experimental Neurobiology, Wenzhou Medical College, Wenzhou, China MOE Laboratory of Bioinorganic and Synthetic Chemistry Lehn Institute of Functional Materials School of Chemistry Sun Yat-Sen University Guangzhou 510275 China State Key Laboratories of Respiratory Diseases; Guangzhou Institutes of Biomedicine and Health; Chinese Academy of Sciences; Guangzhou China Department of Obstetrics and Gynecology, Nanfang Hospital, Southern Medical University, Guangzhou City, People’ Republic of China Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland; Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland Department of pathology Longhua HospitalShanghai University of Traditional Chinese Medicine Shanghai China Department of Biochemistry and Molecular Biology, Hunan Province Key Laboratory of Basic and Applied Hematology, Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Xiangya School of Medicine, Central South University, Changsha 410008, China Department of Neurology The First Affiliated Hospital, Sun Yat‐Sen University Guangzhou 510080 China Department of Neurosurgery Chinese PLA (People’s Liberation Army) General Hospital Beijing 100853 China CSPC Zhongqi Pharmaceutical Technology (Shijiazhuang) Co., Ltd. Shijiazhuang China Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China Key Laboratory of Yangtze River Water Environment of the Ministry of Education, College of Environmental Science and Engineering Tongji University Shanghai China State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, China Department of Neurosurgery First Medical Center of Chinese PLA General Hospital Beijing China Washington University School of Medicine, Saint Louis, MO, USA Department of Breast Surgery, The First Affiliated Hospital with Nanjing Medical University, Nanjing, P.R. China. Department of Chemistry, Iowa State University, Ames, Iowa 50011 State Key Laboratory of Food Science and Resources, Jiangnan University, Wuxi 214122, China; Science Center for Future Foods, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China; International Joint Laboratory on Food Safety, Jiangnan University, Wuxi 214122, China; Jiaxing Institute of Future Food, Jiaxing 314050, China Department of Nursing, Shenzhen Hospital, Southern Medical University, Shenzhen, China. From the Division of Cardiac Surgery, School of Medicine (S.S., R.M., G.E.B., B.W., P.S., S.R.D., B.S.T., S.K.), Department of Pharmaceutical Sciences, School of Pharmacy (M.M.K., Y.A.G., D.R.G.), Division of Endocrinology, Diabetes and Nutrition, Department of Medicine (H.X.), Department of Physiology and Medicine, School of Medicine (L.C.), Department of OB/GYN & Reproductive Science, Department of Biochemistry and Molecular Biology, School of Medicine (P.Y.), and Pulmonary and Critical Care... Department of Internal Medicine & Geriatrics, Zhongnan Hospital of Wuhan University, Wuhan 430072, China Division of Biostatistics, Washington University School of Medicine in St. Louis, St. Louis, Missouri Zhongshan Ophthalmic Center, Sun Yat-Sen University of Medical Science, Guangzhou 510060, China. Key Laboratory of Coastal Zone Environmental Processes, CAS; Shandong Provincial Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; Graduate University of Chinese Academy of Sciences, Beijing 100049, China Merck & Company, West Point, PA 19486 and Lexicon Genetics, The Woodlands, TX 77381 Division of Production and Materials Engineering, Lund University, Lund, Sweden College of Geophysics, Chengdu University of Technology, Chengdu, Sichuan, People’s Republic of China; Geomathematics Key Laboratory of Sichuan Province, Chengdu University of Technology, Chengdu, Sichuan, People’s Republic of China; College of Mathematics and Physics, Chengdu University of Technology, Chengdu, Sichuan, People’s Republic of China School of Public Health, Central South University, Changsha, China. Department of Cardiothoracic Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China Zhejiang University School of Medicine Department of Pharmacy, Affiliated Hangzhou First People’s Hospital, , No. 261 Huansha Road, Hangzhou 310006 , China State Key Laboratory of Respiratory Diseases, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China; The First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510230, China State Key Laboratories of Respiratory Diseases The First Affiliated Hospital of Guangzhou Medical University Guangzhou China; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health (GIBH) Chinese Academy of Sciences Guangzhou China Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA; Program in Medical and Population Genetics, Broad Institute, Cambridge, MA State Key Lab of Reproductive Medicine Nanjing Medical University Nanjing China; Department of Physiology Nanjing Medical University Nanjing China Department of Dermatology Daping Hospital, Army Medical University Chongqing China State Key Laboratory of Respiratory Disease, CAS Key Laboratory of Regenerative Biology, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, People’s Republic of China; University of Chinese Academy of Sciences, Beijing, People’s Republic of China; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou, People’s Republic of China; Guangzhou nBiomed Ltd., Guangzhou, People’s Republic of China Department of Neurosurgery Xuanwu Hospital the Capital Medical University Beijing China School of Pharmacy, Guilin Medical University, Guilin, China Key Laboratory of Oral Biomedical Engineering, Ministry of Education, Sichuan University, Chengdu 610041, China. Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, Worcester, Massachusetts. State Key Laboratory of Ophthalmology Zhongshan Ophthalmic Center, Sun Yat‐sen University Guangzhou China Department of Thoracic Surgery, Changhai Hospital, The Second Military Medical University, Shanghai, China. Division of Biostatistics, Washington University School of Medicine , Saint Louis, Missouri , USA *College of Pharmacy, Sookmyung Women’s University, Seoul 140-742, Republic of Korea; Emergency Office, The First Affiliated Hospital of Nanchang University, China National Laboratory of Solid State Microstructures and Department of Physics, Nanjing University, Nanjing 210093, P R China Bioland Laboratory, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, People’s Republic of China; State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, the First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China; Guangzhou Institute of Infectious Disease, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of China Department of Dermatology, Research Institute of Surgery, Daping Hospital, Third Military Medical University, Chongqing, China. Marine Environmental Monitoring Centre of Ningbo State Oceanic Administration 86 Qiyun Rd Ningbo China Department of Neurosurgery Chinese PLA General Hospital Beijing China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Centre, Sun Yat-sen University, Guangzhou 510000, China Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; School of Materials Science and Engineering, University of Jinan, Jinan 250022, China; University of Chinese Academy of Sciences, Beijing 100049, China Pulmonary and Critical Care Division, Long Island Jewish Medical Center, Long Island Campus for Albert Einstein College of Medicine, New Hyde Park, New York 11040 Department of Ophthalmology, Affiliated to Qingdao University Yuhuangding Hospital of Yantai, Yantai, Shandong 264000, P.R. China Research & Development, Bristol-Myers Squibb Company, 5 Research Parkway, Wallingford, Connecticut 06492, United States Key Laboratory for Special Functional Materials of Ministry of Education, Henan University, Kaifeng, Henan 475004, P. R. China Key Laboratory of State Administration of Traditional Chinese Medicine, Sunshine Lake Pharma Co., LTD, 368 Changan Zhenan Middle Road, Changan Town, Dongguan 523850, Guagdong Province, China Behavior Rehabilitation Training Research Institution School of Psychology Northwest Normal University Lanzhou China Department of Rheumatology, Fujian Medical University Union Hospital, Fuzhou, China Department of Breast Surgery First Affiliated Hospital with Nanjing Medical University Nanjing China School of Chemical Engineering and Advanced Materials The University of Adelaide Adelaide SA 5005 Australia Interventional Platform Education, Stanford, California Department of Cardiology, The Central Hospital of Wuhan, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China. Department of Metabolism and Endocrinology, The First Affiliated Hospital, University of South China, Hengyang, Hunan, P.R. China. Department of Ophthalmology and Visual Sciences University of Alabama at Birmingham School of Medicine Birmingham AL USA; The First Affiliated Hospital of Chongqing Medical University Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute Chongqing China Department of Pharmacy, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang Province, China State Key Laboratory of Respiratory Diseases Guangzhou Institutes of Biomedicine and Health (GIBH) Chinese Academy of Sciences Guangzhou 510530 P. R. China; State Key Laboratory of Respiratory Disease The First Affiliated Hospital of Guangzhou Medical University Guangzhou 510120 P. R. China Department of Pharmacognosy, School of Pharmacy, Second Military Medical University, Shanghai, China; Department of Gynecology, Columbia University, New York, New York Jennifer A. Woo Baidal, Kayla Morel, Kelsey Nichols, and Erin Elbel are with the Division of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, Columbia University Medical Center, New, York, NY. Nalini Charles is with the New York Presbyterian Hospital Special Supplemental Nutrition, Program for Women, Infants, and Children, New York, NY. Jeff Goldsmith is with the Mailman School of Public Health, Columbia University Medical Center, New York, NY. Ling Chen is with the... Department of Endocrinology (G.C., L.C., J.W., J.Y., L.Li, L.Lin, K.T., H.H., J.Li., W.L., H.C., M.L., X.G., S.P.), Fujian Provincial Hospital, Key Laboratory of Endocrinology, Fujian Medical University, Fuzhou 350001, China Key Laboratory for Special Functional Materials of Ministry of Education National & Local Joint Engineering Research Centre for High‐Efficiency Display and Lighting Technology School of Materials and Engineering Collaborative Innovation Centre of Nano Functional Materials and Applications Henan University Jinming Avenue, Jinming District Kaifeng 475004 P. R. China Active Carbohydrate Research Center, Chongqing Key Laboratory of Inorganic Functional Materials, College of Chemistry, Chongqing Normal University, Chongqing, China Department of Gynaecology, People’s Hospital Affiliated to Cangzhou Medical College, Cangzhou, China School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China. E-mail: [email protected]. Medicine, and; the 3Center for Heart, Hypertension and Kidney Disease, University of Maryland School of Medicine, Baltimore, Maryland; and State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China; Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, People’s Republic of China Department of Neurosurgery, Chinese People’s Liberation Army of China (Pla) General Hospital, Medical School of Chinese Pla, Institute of Neurosurgery of Chinese Pla, Beijing, China Guangdong Laboratory of Computational BiomedicineGuangzhou Institutes of Biomedicine and Health Guangzhou China; State Key Laboratories of Respiratory DiseasesGhuangzhou Institutes of Biomedicine and HealthChinese Academy of Sciences Guangzhou China; School of Life ScienceUniversity of Science and Technology of China Hefei China Department of Emergency Surgery; The Second Affiliated Hospital of Anhui Medical University; Hefei; China College of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094, China School of Nuclear Science and Technology, Naval University of Engineering, Wuhan 430033, China Department of Physiology and Medicine, University of Maryland School of Medicine, Baltimore, Maryland Department of Infectious Diseases, Institute for Viral Hepatitis, Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Second Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China State Key Laboratory of Respiratory Disease Guangzhou Institutes of Biomedicine and Health (GIBH) Chinese Academy of Sciences Guangzhou 510530 China; University of Chinese Academy of Sciences Beijing 100049 China; The First Affiliated Hospital of Guangzhou Medical University Guangzhou 510060 China Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong 510080, China Priority Research Centre for Healthy Lungs, Hunter Medical Research Institute and School of Biomedical Sciences and Pharmacy University of Newcastle Newcastle NSW Australia Department of Cardiac Surgery, Fujian Medical University Union Hospital, Fuzhou, Fujian, China State Key Lab of Reproductive Medicine; Department of Physiology Department of Plant Pathology College of Plant Protection Anhui Agricultural University, Key Laboratory of Biology and Sustainable Management of Plant Diseases and Pests of Anhui Higher Education Institutes Hefei Anhui China Department of Pathology Xiangya Hospital Central South University Changsha Hunan China; NHC Key Laboratory of Carcinogenesis (Central South University), Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education) Cancer Research Institute and School of Basic Medicine Central South University Changsha Hunan China Department of Pathology Xijing Hospital, Fourth Military Medical University Xi’an China Lab Teaching and Management Center, Chongqing Medical University, Chongqing 400016, P.R. China Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China; Hubei Province Key Laboratory of Molecular Imaging, Wuhan 430022, China The Eye and ENT Hospital of Fudan University, Shanghai, People’s Republic of China Department of Neurosurgery, the First Medical Center, Chinese PLA General Hospital, Beijing, China Xinjiang Key Laboratory of Biological Resources and Genetic Engineering, College of Life Science and Technology, Xinjiang University, Urumqi, China Neurobiology Laboratory, Department of Anatomy, Institute of Basic Medical Sciences, University of Tsukuba, Ibaraki, Tsukuba 305, Japan Department of Pathology Nanjing Drum Tower Hospital Nanjing Jiangsu Province China Department of Physiology Nanjing Medical University Nanjing China Nanjing Maternal and Child Health Institute, Women's Hospital of Nanjing Medical University (Nanjing Maternity and Child Health Care Hospital) Nanjing China State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, People's Republic of China, Graduate School of the Chinese Academy of Sciences, Beijing 100039, People's Republic of China, and Department of Chemistry, Fuzhou University, Fuzhou, Fujian 350002, People's Republic of China AGCU ScienTech Incorporation Wuxi P. R. China Department of Physiology, Shandong Provincial Key Laboratory of Pathogenesis and Prevention of Neurological Disorders and State Key Disciplines, Physiology, School of Basic Medicine, Qingdao University, Qingdao 266071, China State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, P. R. China, and Graduate School of the Chinese Academy of Sciences, Beijing 100039, P. R. China Department of Chemistry and Centre for Atomic Engineering of Advanced Materials, Key Laboratory of Structure and Functional Regulation of Hybrid Materials of Ministry of Education, Institutes of Physical Science and Information Technology and Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials, Anhui University, Hefei, Anhui 230601, China University of California San Francisco Division of Biomaterials and Bioengineering, Preventive and Restorative Dental Sciences, California, San Francisco, USA Department of Physiology; University of Maryland School of Medicine; Baltimore Maryland USA; Department of Medicine; University of Maryland School of Medicine; Baltimore Maryland USA Division of Pathology,Xijing Hospital of Digestive Diseases,Fourth Military Medical University,Xi’an,China Cancer Research Institute, Central South University, Changsha, Hunan, China; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Hunan, China; Key Laboratory of Carcinogenesis, Ministry of Health, Hunan, China Department of Mechanical Engineering, San Diego State University, San Diego, CA, 92182-1323 Department of Ophthalmology, Eye and ENT Hospital, Fudan University, Shanghai, China; Key Laboratory of Visual Impairment and Restoration, Shanghai 200031, China Department of Clinical Pharmacy, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine , Hangzhou , China Key Laboratory for Ultrafine Materials of Ministry of Education Shanghai Engineering Research Center of Multiscale Nanomaterials School of Materials Science and Engineering East China University of Science & Technology Shanghai 200237 China Department of Endocrinology, Fujian Provincial Hospital, Fujian Academy of Medical Sciences, Fujian Medical University, Fuzhou 350001, China Molecular Sciences and Candidate Optimization, Disease Sciences and Biologics, Bristol-Myers Squibb Research & Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, People's Republic of China; State Key Laboratory of Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People's Republic of China Ministry of Education Key Laboratory of Analytical Science of Food Safety and Biology; Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety; College of Chemistry; Fuzhou University; Fuzhou 350116 Department of Neurology; The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology; Chongqing 400016 China Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, School of Food Science and Engineering, South China University of Technology, Guangzhou, P.R. China. Department of Internal Medicine, Shanghai Yongci Rehabilitation Hospital, Shanghai 201107, China Key Laboratory of Agricultural Environment Microbiology, Ministry of Agriculture, College of Life Sciences, Nanjing Agricultural University, Nanjing 210095, PR China Xinzhuang Community Health Service Center Department of General Surgery, Xiangya Hospital, Central South University, Changsha, Hunan, China Department of Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an 710061, China Center for Genomic Medicine, Massachusetts General Hospital, Boston, Massachusetts; Programs in Metabolism and Medical & Population Genetics, Broad Institute of MIT and Harvard, Cambridge, Massachusetts; Department of Medicine, Harvard Medical School, Boston, Massachusetts; Diabetes Unit, Massachusetts General Hospital, Boston, Massachusetts State Key Laboratory of Pollution Control and Resource Reuse, School of Environment, Nanjing University, Nanjing 210023, PR China Ministry of Education Key Laboratory for Analytical Science of Food Safety and Biology; Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety; and College of Chemistry; Fuzhou University; Fuzhou School of Forensic MedicineSouthern Medical UniversityGuangzhouChina Department of Respiratory and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, China State Key Laboratory of Cancer Biology, Department of Pathology, Xijing Hospital and School of Basic Medicine, Fourth Military Medical University, Xi’an From the Departments of Molecular and Medical Pharmacology,2Ophthalmology, Jules Stein Eye Institute, and Institute of Clinical Medicine, the First Affiliated Hospital of University of South China, Hengyang, China. State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangzhou, China Endocrinology and Metabolism Department Peking University People's Hospital Beijing China Department of Ophthalmology, Eye & ENT Hospital of Fudan University, Shanghai, China; Shanghai Key Laboratory of Visual Impairment and Restoration, Science and Technology Commission of Shanghai Municipality, Shanghai, China Anhui Key Laboratory of Chem-Biosensing; College of Chemistry and Materials Science; Center for Nanoscience and Nanotechnology; Anhui Normal University; Wuhu School of Biotechnology and Health Sciences, Wuyi University, Jiangmen 529020, China Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Key Laboratory of Visual Impairment and Restoration and Key Laboratory of Myopia, Ministry of Health, Hanoi, Vietnam State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China Department of Thyroid and Breast Surgery First Affiliated Hospital of Fujian Medical University Fuzhou China Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, USA Shenzhen Center for Chronic Disease Control and Prevention, Shenzhen, China Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama;; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China; Guizhou Provincial Key Laboratory of Computational Nano-Material Science, Guizhou Education University, Guiyang 550018, China Department of Neurology the First Affiliated Hospital of Kunming Medical University Kunming Yunnan China; Department of Neurology the First People's Hospital of Yunnan Province Kunming Yunnan China Department of Chemistry, Yunnan Normal University, Kunming 650092, People’s Republic of China State Key Laboratory for Mesoscopic Physics and Frontiers Science Center for Nano‐optoelectronics School of Physics Peking University Beijing 100871 China Hubei Collaborative Innovation Center for Advanced Organic Chemical Materials Ministry‐of‐Education Key Laboratory for the Synthesis and Application of Organic Functional Molecules & College of Chemistry and Chemical Engineering Hubei University Wuhan China Centre for Polymer from Renewable Resources, School of Food Science and Engineering, South China University of Technology, Guangzhou, China School of Chemical Engineering and Advanced Materials The University of Adelaide Adelaide South Australia 5005 Australia Department of Ophthalmology, The Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, China Guangzhou Institute of Biomedicine & Health Chinese Academy of Sciences Guangzhou Guangdong 510530 P.R. China Department of Central Laboratory, the 71st Group Army Hospital of PLA Army, The Affiliated Huaihai Hospital of Xuzhou Medical University, Jiangsu, China Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, China Department of Neonatology, Zhongshan Hospital of Xiamen University, Xiamen, Fujian, China (mainland) Nursing Department, Shaanxi Province Friendship Hospital, Xi’an, China The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, and Chongqing Eye Institute, Chongqing, China. Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China; Immunotherapy Institutes, Fujian Medical University, Fuzhou, China Graduate School, Shanxi Medical University, Taiyuan, Shanxi, China; Department of Plastic Surgery and Burn Repair, Chinese PLA 309 Hospital, Beijing, China Center for Diabetes Research, University of Texas, Southwestern Medical Center, TX 75235.; Veterans Affairs Medical Center, Dallas, TX 75216 State Key Laboratory of Molecular Engineering of Polymers, Department of Macromolecular Science, Shanghai Stomatological Hospital & School of Stomatology, Laboratory of Advanced Materials, Fudan University, Shanghai 200433, People’s Republic of China Lehn Institute of Functional Materials, School of Chemistry, Sun Yat-Sen University, Guangzhou 510275, P. R. China State Key Laboratory of Respiratory Disease Guangzhou Institutes of Biomedicine and Health (GIBH) Chinese Academy of Sciences Guangzhou 510530 China Doctor of Medicine, Key Laboratory of Molecular Biology of Infectious Diseases, Ministry of Education, Chongqing Medical University Diabetes Unit and Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA Department of Plastic and Cosmetic Surgery; Maternal and Child Health Medical Institute; Obstetrics and Gynecology Hospital Affiliated to Nanjing Medical University; Nanjing 210004 China State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, No. 163 Xianlin Avenue, Nanjing 210023, P. R. China Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University , Guangzhou, Guangdong 510080 , China Department of Children Health Care, Nanjing Maternity and Child Health Care Hospital, Nanjing Medical University, Nanjing, China.; Institute of Pediatrics, Nanjing Medical University, Nanjing, China. Laboratory of Reproductive Medicine, Nanjing Medical University, Jiangsu, China; Department of Physiology, Nanjing Medical University, Jiangsu, China; Department of Physiology, Nagoya University Graduate School of Medicine, Nagoya, Japan Key Laboratory of Optoelectronic Materials Chemistry and Physics, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, People’s Republic of China Respiratory Medicine Hunan Provincial People's Hospital Changsha China Institute of Crop Germplasm Resources of Shanxi Academy of Agricultural Sciences Shanxi Key Laboratory of Genetic Resources Genetic Improvement of Minor Crops Key Laboratory of Crop Gene Resources Germplasm Enhancement on Loess Plateau Ministry of Agriculture Taiyuan P.R. China Key Laboratory of Chem−Biosensing, Anhui province; Key Laboratory of Functional Molecular Solids, Anhui province; College of Chemistry and Materials Science, Anhui Normal University, Wuhu 241000, People’s Republic of China State Key Laboratory of Food Science and Resources Jiangnan University Wuxi China; Science Center for Future Foods Jiangnan University Wuxi China; School of Food Science and Technology Jiangnan University Wuxi China; International Joint Laboratory on Food Safety Jiangnan University Wuxi China Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences National Health Commission Science and Technology Innovation Platform for Nutrition and Safety of Microbial Food Guangzhou Guangdong China Columbia University College of Physicians and Surgeons New York New York USA Department of Child Health Care Hangzhou Women's Hospital, Hangzhou Maternity and Child Health Care Hospital Hangzhou China Institute of Digestive Endoscopy and Medical Center for Digestive Disease, The Second Affiliated Hospital, Nanjing Medical University, Nanjing, Jiangsu 210011, P.R. China Department of Medical Oncology Fujian Cancer Hospital and Fujian Medical University Cancer Hospital Fuzhou China Division of Biostatistics, Washington University in St. Louis School of Medicine, St. Louis, Missouri Department of Oncology, Changhai Hospital Affiliated to Naval Military Medical University, Shanghai 200433, P.R. China Department of Histology and Embryology, Shantou University Medical College, Shantou 515041, China; Department of Anatomy, Basic Medical Science Building, Chinese University of Hong Kong, Shatin, Hong Kong, and Key Joint CUHK–JiNan University Laboratory for Regenerative Medicine.; Clinical Immunology Unit, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong.; Key Immunopathology Laboratory of Guangdong Province, Shantou 515041, China; Genetics Research Center, Southeast University Medical School, Nanjing 210009, China State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China Department of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China; Chongqing Key Laboratory of Neurology, 1 Youyi Road, Yuzhong District, Chongqing 400016, China Department of Rehabilitation Medicine, Guangdong Engineering Technology Research Center for Rehabilitation Medicine and Clinical Translation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Tianjin 300071, P.R. China Pulmonary and Critical Care Medicine, Hunan Provincial People’s Hospital, The First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China. Key Laboratory of Synthetic Biology, Institute of Plant Physiology and Ecology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200032, China Medical School of Chinese PLA Beijing China; Department of Neurosurgery Chinese PLA General Hospital Beijing China Columbia University Key Lab for Special Functional Materials of Ministry of Education; Collaborative Innovation Center of Nano Functional Materials and Applications; Henan University; Kaifeng; People's Republic of China Shenzhen Institute of Synthetic Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China; Key Laboratory of Quantitative Engineering Biology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China; Shenzhen Key Laboratory of Synthetic Genomics, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Shenzhen, China; Guangdong Provincial Key Laboratory of Synthetic Genomics, Shenzhen, China Institute of TCM and Natural Products, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, People’s Republic of China Tuberculosis Division of Respiratory and Critical Care Medicine, Affiliated Hospital of Zunyi Medical University, Guizhou, China Department of Medical Sciences, Medical College, Xiamen University, Xiamen, Fujian, China; Clinical Research Institute, The First Affiliated Hospital, University of South China, Hengyang, Hunan, China Department of Chemistry, State Key Laboratory of Elemento-Organic Chemistry, Nankai University, Collaborative Innovation Center of Chemical Science and Engineering, Tianjin 300071, People’s Republic of China; College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang, Jiangxi 330022, People’s Republic of China College of life science, Fujian Normal University, Fuzhou 350007, China. Guangzhou Red Cross Hospital, Guangzhou, China Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou 510060, China. [email protected] Key Laboratory of Material Simulation Methods and Software of Ministry of Education and State Key Laboratory of Superhard Materials, College of Physics, Jilin University 1 , Changchun 130012, People’s Republic of China Department of Nursing, Shenzhen Hospital, Southern Medical University, Shenzhen, Guangdong 518101, P.R. China 3Institute of Clinical Immunology, Affiliated Union Hospital, Fujian Medical University, Fuzhou, China Department of Life Science & Center for Ecology and Environment Tunghai University Taichung Taiwan The Second Affiliated Hospital of Nanchang University, Nanchang University, Nanchang 330000, China; State Key Laboratory of Food Science and Technology, Nanchang University, Nanchang 330047, China Authors' Affiliations: 1Institute of Gastroenterology and 2Institute of Burn Research, Southwest Hospital, Third Military Medical University, Chongqing, PR China Columbia University College of Physicians and Surgeons, New York, New York Key Laboratory of Xinjiang Endemic and Ethnic Diseases, Medicine School of Shihezi University, Shihezi, Xinjiang 832008, P.R. China Department of Endocrinology and Metabolism, First Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang Hunan 421001. [email protected]. Agriculture and Agri‐Food Canada London Research and Development Centre 1391 Sandford Street London ON Canada Department of Forensic Genetics, School of Forensic Medicine, Southern Medical University, Guangzhou, China Department of Ophthalmology and Visual Sciences, School of Medicine, University of Alabama at Birmingham, Birmingham, Alabama;; State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China; Molecular and Performance Materials Cluster, Institute of Materials Research and Engineering, 3 Research Link, Singapore 117602, and Department of Mechanical Engineering, Hong Kong University of Science and Technology, Clear Water Bay, Kowloon, Hong Kong, China School of Public Health, Central South University, Changsha,China. Institute of Microbiology, Guangdong Academy of Sciences, State Key Laboratory of Applied Microbiology Southern China, Guangdong Provincial Key Laboratory of Microbial Safety and Health, Science and Technology Innovation Platform for Nutrition and Safety of Microbial Food, National Health Commission, Guangzhou, China Department of Neurosurgery, Xuanwu Hoaspital, Capital University of Medical Sciences, Beijing 100053. [email protected] Department of Gastrointestinal Surgery Xiangya Hospital Central South University Changsha Hunan China College of Pharmacy, Xinjiang Medical University, Urumqi 830011, China School of Forensic Medicine, Southern Medical University, Guangzhou 510515, China Division of Biomaterials and Bioengineering Department of Preventive and Restorative Dental Sciences University of California San Francisco California Department of Medical and Bioengineering Science, Graduate School of Natural Science and Technology, Okayama University Okayama 700-8530, Japan ; Department of Pathology, Tianjin Central Hospital of Gynecology Obstetrics Tianjin 300100, People's Republic of China ; Japan Society for The Promotion of Science Tokyo 102-8472, Japan. 1Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China. Department of Internal Medicine University of Kansas Medical Center Kansas City KS USA Bioengineering College, Chongqing University, Chongqing 400044, China. Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA. Division of Biostatistics, Washington University in St. Louis, St. Louis, MO, USA Binjiang Dental Clinic of Hangzhou Sunshine Medical Management Co.,Ltd, Hangzhou 310051, China. Department of Emergency, Zhangzhou Municipal Hospital of Fujian Province, Zhangzhou, Fujian 363000, P.R. China Department of Plastic & Cosmetic Surgery Women's Hospital of Nanjing Medical University (Nanjing Maternity and Child Health Care Hospital) Nanjing China Department of Pathology, Peking University Health Science Center, Beijing 100083, China. Pathology, Nanjing Drum Tower Hospital Clinical College of Nanjing Medical University, Nanjing, Jiangsu, China. State Key Laboratory for Pollution Control and Resource Reuse, College of Environmental Science and Engineering, Tongji University, Shanghai 200092, China;Shanghai Institute of Pollution Control and Ecological Security, Shanghai 200092, China. Department of Obstetrics and Gynecology, Rocket Force Characteristic Medical Center, Beijing, China. Department of Neurosurgery, Chinese People’s Liberation Army of China (PLA) General Hospital, Medical School of Chinese PLA, Institute of Neurosurgery of Chinese PLA , Beijing , China Department of Cardiovascular Medicine, Second Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, China. Neonatal Intensive Care Unit, Department of Pediatric Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology Wuhan China Department of Biochemistry and Molecular Biology, Hunan Province Key Laboratory of Basic and Applied Hematology, Hunan Key Laboratory of Animal Models for Human Diseases, School of Life Sciences, Xiangya School of Medicine, Central South University, Changsha, 410008 Hunan, China Department of Clinical Laboratory, Xiamen Maternity and Child Health Care Hospital, Xiamen, Fujian 361003, China. [email protected]. Laboratory of Reproductive Medicine (Y.B., L.C.), Nanjing Medical University, Nanjing 210029, China; Department of Physiology (Y.B., F.C., R.Z., P.-P.J., L.C.), Nanjing Medical University, Nanjing 210029, China; Department of Physiology (M.S., L.C.), Nagoya University Graduate School of Medicine, 65 Tsurumai, Nagoya 466-8550, Japan Department of Otolaryngology, Sun Yat-Sen Memorial Hospital, and Institute of Hearing and Speech-Language Science, Sun Yat-Sen University; Department of Hearing and Speech Science, Xin Hua College of Sun Yat-Sen University, Guangzhou, China Ministry of Education Engineering Research Centre of Starch & Protein Processing, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, South China University of Technology, Guangzhou 510640, China Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350005, P.R. China Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education; Hangzhou Normal University; Hangzhou; P.R. China Shenzhen Hospital of Southern Medical University, Shenzhen, Guangdong 518101, China Key Laboratory of Coastal Environmental Processes and Ecological Remediation, Shandong Provincial Key Laboratory of Coastal Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; University of Chinese Academy of Sciences, Beijing 100049, China Institute of Clinical Medicine, The First Affiliated Hospital of University of South China, Hengyang, Hunan 421001, P.R. China Institute of Digestive Endoscopy and Medical Center for Digestive Diseases, Second Affiliated Hospital of Nanjing Medical University, Nanjing, China Ministry of Education Engineering Research Center of Starch & Protein Processing, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China Department of Pediatrics, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China Key Laboratory of Applied Surface and Colloid Chemistry (Ministry of Education), School of Chemistry and Chemical Engineering, Shaanxi Normal University, Xi’an 710062, P.R. China From the Molecular and Clinical Hematology Branch and Laboratory of Cell Biochemistry and Biology, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD. Department of Obstetrics and Gynecology, Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu 214062, P.R. China 1Neuro-Oncology and Departments of Tongji University, Key Laboratory of Yangtze Water Environment of Ministry of Education, College of Environmental Science and Engineering, Shanghai-200092, People's Republic of China Department of Physiology and Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA Department of Oncology, Changhai Hospital, Naval Medical University Shanghai 200433, The People's Republic of China. Clinical Laboratory People's Hospital of Jiangyou Mianyang Sichuan China Department of Laboratory Medicine, Shiyan Taihe Hospital, College of Biomedical Engineering, Hubei University of Medicine, Shiyan, China School of Computer Science, FEIT, University of Technology Sydney, Ultimo, NSW 2007, Australia Department of Neurosurgery, Xuanwu Hospital Capital Medical University Beijing People's Republic of China Department of Nursing, Shenzhen hospital of Southern Medical University, Shenzhen, Guangdong, China School of Food Science and Engineering, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, Engineering Research Center of Starch and Vegetable Protein Processing Ministry of Education, South China University of Technology, Guangzhou 510640, China Department of Pathology, the Nanjing Drum Tower Hospital affiliated to Nanjing University Medical School Key Laboratory for Animal Disease-Resistance Nutrition of the Ministry of Agriculture, Animal Nutrition Institute, Sichuan Agricultural University, Chengdu, China; Chengdu Research Base of Giant Panda Breeding, Northern Suburb, Chengdu, China State Key Laboratory of Superhard Materials, College of Physics, Jilin University, Changchun 130012, People’s Republic of China Faculty of Animal Science and Technology, Yunnan Agricultural University, Kunming, Yunnan, China; Yunnan Animal Science and Veterinary Institute, Kunming, Yunnan, China; Department of Nuclear Medicine, the First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China State Key Laboratory of Bioelectronics; Jiangsu Key Laboratory for Biomaterials and Devices; School of Biological Science and Medical Engineering & Collaborative Innovation Center of Suzhou Nano Science and Technology; Southeast University; Nanjing 210096 Department of Ophthalmology of Shanghai Tenth People's Hospital and Tongji Eye Institute, Tongji University School of Medicine, Shanghai, China 3Department of Regenerative Medicine and Stem Cell Research Center, Tongji University School of Medicine, Shang Department of Statistical Analysis and Medical Records The Fifth Affiliated Hospital of Sun Yat‐sen University Zhuhai China State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou 510530; Department of Medical Biotechnology, University of Science & Technology of China, Hefei 230026, China Department of Pharmacy the People’s Hospital of Hanchuan (Hanchuan Hospital of People’s Hospital Affiliated to Wuhan University) Hanchuan Hubei China; Department of Pharmacy Wuhan Third Hospital (Tongren Hospital of Wuhan University) Wuhan Hubei China Department of Neurosurgery, Chinese PLA General Hospital, Beijing 100853, P.R. China Department of Physics, The University at Albany—SUNY, Albany, New York 12222 Key Laboratory of Agricultural Microbiomics and Precision Application (MARA), Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou 510070, China Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine University of Kansas Medical Center Kansas City Kansas USA Department of Gynecology, Affiliated Hospital of Jiangnan University, Wuxi 214062, China; Wuxi Medical College, Jiangnan University, Wuxi 214000, China Washington University in St Louis, Saint Louis, MO, USA Department of Emergency, Fifth Medical Center of Chinese PLA Hospital, Beijing, China Central Laboratory, Fujian Medical University Union Hospital, Fuzhou, China State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, China From the Division of Gynecologic Oncology, Vincent Department of Obstetrics and Gynecology, Massachusetts General Hospital, Harvard Medical School (A.M., M.G.C.), and the Department of Health Care Policy, Harvard Medical School, and the Division of General Internal Medicine, Brigham and Women’s Hospital (N.L.K.) — all in Boston; the Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Prentice Women’s Hospital (D.J.M., J.Y., B.-L.L.S., A.A., E.L.B., M.K., S.S.), and the Division of... Drug and Vaccine Research Center, Guangzhou National Laboratory, Guangzhou, China; State Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China Evidence-Based Medicine Center, MOE Virtual Research Center of Evidence-based Medicine at Zunyi Medical College, Affiliated Hospital of Zunyi Medical College, Zunyi 563003, Guizhou, China; Department of Respiratory Medicine (Center for Evidence-Based and Translational Medicine of Major Infectious Diseases), Affiliated Hospital of Zunyi Medical College, Zunyi 563003, Guizhou, China Department of Oncology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine (TCM), Shanghai, China Henan Academy of Sciences, Henan Napu Biotechnology Co., Ltd., Zhengzhou 450002, China Division of Biostatistics, Washington University in St. Louis, St. Louis, MO. Columbia Universtiy College of Physicians and Surgeons New York New York USA Neurosurgery, The First Medical Center of PLA General Hospital, Beijing, China Teva Branded Pharmaceutical Products R&D Inc, Frazer, PA, USA; State Key Laboratory of Respiratory Disease, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China Department of Neurology; The First Affiliated Hospital of Chongqing Medical University; Chongqing 400016 China Normandie Univ; INSA Rouen; UNIROUEN; CNRS; COBRA (UMR 6014) Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, New York State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Biomedicine and Health (GIBH), Chinese Academy of Sciences, Guangzhou, China; State Key Laboratory of Respiratory Diseases, Guangzhou Institute of Respiratory Diseases, Guangzhou Medical College, Guangzhou, China Department of Pathology, Tianjin Central Hospital of Gynecology Obstetrics Nankai University Affiliated Maternity Hospital, Tianjin Key Laboratory of Human Development and Reproductive Regulation Tianjin China Ministry of Education Engineering Research Center of Starch & Protein Processing, Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety, School of Food Sciences and Engineering, South China University of Technology, Guangzhou 510640, China Center for Genomic Medicine and Diabetes Unit, Massachusetts General Hospital, Boston, MA, USA Department of Biliary-Hepatic Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550025, P.R China School of Public Health, Medical College of Soochow University, 199 Ren’ai Road, Suzhou, Jiangsu 215123, China Department of Gastroenterology, Southwest Hospital, Third Military Medical University, Chongqing, China Guangzhou Laboratory, Guangzhou 510005, People’s Republic of China Shanghai Changzheng Hospital and Second Military Medical University Shanghai China Department of Oncology, Changhai Hospital, Naval Medical University, Shanghai 200433, P.R. China College of Acupuncture-Moxibustion and Tuina, Chengdu University of TCM, Chengdu 610075, Sichuan Province, China. School of Mathematics and Statistics, Fuzhou University, Fuzhou 350116, China Department of Orthodontics, Shanghai Stomatological Hospital & School of Stomatology, Department of Macromolecular Science, Fudan University, Shanghai 200433, China; State Key Laboratory of Molecular Engineering of Polymers, Laboratory of Advanced Materials, Fudan University, Shanghai 200433, China Hangzhou Dental Hospital, Hangzhou 310015, Zhejiang Province, China. E-mail:[email protected] College of Chemistry and Chemical Engineering, Key Lab of Fluorine and Silicon for Energy Materials and Chemistry of Ministry of Education, Jiangxi Normal University, Nanchang 330022, Jiangxi, P. R. China College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, People’s Republic of China Department of Physiology, Ningxia Medical University, Yinchuan, Ningxia, P. R. China; Endocrine Testing Center, General Hospital of Ningxia Medical University, Yinchuan, Ningxia, P. R. China State Key Laboratory of Respiratory Diseases, National Clinical Research Center of Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, People’s Republic of China; Institute of Infectious Diseases, Guangzhou Eighth people’s Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of China; Guangzhou Regenerative Medicine and Health-Guangdong Laboratory (GRMH-GDL), Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, People’s Republic of China Divisions of Genetic and Reproductive Toxicology and Biochemical Toxicology, National Center for Toxicological Research, U.S. Food and Drug Administration, Jefferson, Arkansas 72079 Department of Pharmacognosy, School of Pharmacy Second Military Medical University, Shanghai 200433, P.R. China Department of Gynecology and Obstetrics PLA Rocket Force Characteristic Medical Center Beijing China Department of Gastrointestinal Surgery, Xiangya Hospital, Central South University, Changsha 410008, People’s Republic of China Department of Neurosurgery, Chinese People's Liberation Army General Hospital, Beijing 100036, P.R. China State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, People’s Republic of China, and Graduate School of Chinese Academy of Sciences, Beijing 100039, People’s Republic of China Department of Physiology, Shanxi Medical University, Key Laboratory of Cellular Physiology at Shanxi Medical University, Ministry of Education, Taiyuan 030001, China. State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing, China; Department of Physiology, Nanjing Medical University, Nanjing, China State Key Laboratory of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China; School of Medicine and Institute of Molecular Medicine, Huaqiao University, Quanzhou, China Department of Pediatrics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China. From the Department of Cardiovascular Medicine (L.C., K.N., T.M., E.I., M.M., K.N., K.S., K.E.) and Digital Medicine Initiative (J.K.), Graduate School of Medical Science, Kyushu University, Fukuoka, and Hosokawa Micron Corporation (H.T.), Osaka, Japan. Department of Oncology, Affiliated Hospital of Qingdao University, Qingdao, China; Department of Oncology, Qingdao Municipal Hospital, Qingdao, China State Key Laboratory of Respiratory DiseaseGuangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences 510530 Guangzhou China; University of Chinese Academy of Sciences 100049 Beijing China; The Guangzhou 8th People’s HospitalThe First Affiliated Hospital of Guangzhou Medical University 510060 Guangzhou China Shanghai Engineering Research Center of Hierarchical Nanomaterials School of Materials Science and Engineering East China University of Science and Technology Shanghai 200237 China Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 200032, Shanghai, China Division of Biostatistics, Washington University School of Medicine in St Louis, St Louis, MO. Chinese PLA General Hospital and PLA Medical College Chinese PLA Institute of Neurosurgery Beijing China MOE Laboratory of Bioinorganic and Synthetic Chemistry; State Key Laboratory of Optoelectronic Materials and Technologies; Lehn Institute of Functional Materials; School of Chemistry and Chemical Engineering; Sun Yat-Sen University Department of Gastrointestinal Surgery, Xiangya Hospital No. 87 Xiangya Road, Changsha, Hunan, China. Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, and Division of Nuclear Medicine, Department of Radiology, University of Massachusetts Medical School, 55 Lake Avenue North, Worcester, Massachusetts 01655 Ling Chen, MD, PhD, is Assistant Professor, Division of Biostatistics, School of Medicine, Washington University in St. Louis, St. Louis, MO. Department of Nursing,Shenzhen Hospital, Southern Medical University, Shenzhen 518101, China Department of General Practice, Zhongnan Hospital of Wuhan University, Wuhan University, Wuhan, China Department of Obstetrics and Gynecology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine University of Science and Technology of China Hefei Anhui P.R. China School of Biotechnology and Health Sciences Wuyi University Jiangmen 529020 P. R China Second Department of Acupuncture and Moxibustion, Affiliated Hospital of Tianjin Academy of TCM, Tianjin 300120, China. Guangzhou Institutes of Biomedicine and Health (GIBH); Chinese Academy of Sciences; Guangzhou 510530; China; State Key Laboratory of Respiratory Disease The First Affiliated Hospital of Lanzhou University, Lanzhou 730000, Gansu, China Department of Neurosurgery, The First Medical Centre, Chinese PLA General Hospital, Beijing, China 1Center for Medicine Research, Xiangya Hospital, Central South University, Changsha, Hunan, China.; 2Cancer Research Institute, School of Basic Medicine, Central South University, Changsha, Hunan, China.; 3Key Laboratory of Carcinogenesis and Cancer Invasion (Central South University), Ministry of Education, Hunan, China.; 4Key Laboratory of Carcinogenesis (Central South University), Ministry of Health, Hunan, China. Henan Key Laboratory of Chemical Biology and Organic Chemistry Key Laboratory of Applied Chemistry of Henan Universities; Zhengzhou University; Zhengzhou; P.R. China Xinzhuang Community Health Service Center Shanghai China Department of Cardiology, Affiliated Hospital of North Sichuan Medical College, Nanchong, China Biostatistics Department of Otorhinolaryngology Affiliated Hospital of Guangxi Medical College Nanning China College of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330022, P. R. China School of Forensic Medicine, Southern Medical University, Guangzhou, China Department of Oncology Qingdao Municipal Hospital Qingdao China Department of Otorhinolaryngology Head and Neck Surgery, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai, PR China Department of Neurosurgery, General Hospital of PLA, Beijing, China Center for Genomic Medicine, Massachusetts General Hospital, Boston, MA; Diabetes Unit, Massachusetts General Hospital, Boston, MA; Programs in Metabolism and Medical and Population Genetics, Eli and Edythe L. Broad Institute of MIT and Harvard, Cambridge, MA Key Laboratory for Polymeric Composite and Functional Materials of Ministry of Education, Key Laboratory of High-Performance Polymer-Based Composites of Guangdong Province, School of Chemistry, Sun Yat-sen University, Guangzhou510275, China Department of Research and Development, AllBio Life Incorporation, Taichung 402, Taiwan Department of Cardiovascular Internal Medicine, Affiliated second Hospital, Guangdong Medical University College of Chemistry and Chemical Engineering, Key Laboratory of Functional Small Molecules for Ministry of Education, Jiangxi Normal University, Nanchang 330022, Jiangxi, P. R. China Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, University of Kansas Medical Center, Kansas City, Kansas Department of Biliary‑Hepatic Surgery, The Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou 550001, P.R. China Diabetes Care and Research Center of Jiangsu Province Official Hospital, Nanjing, China Institute of Immunotherapy, Fujian Medical University, Fuzhou 350122, Peoples’ Republic of China;; Laboratory of Immunotherapy, Sun Yat-Sen University, Guangzhou 510080, Peoples’ Republic of China; Department of Endocrinology and Metabolism, Peking University People's Hospital, Peking University Diabetes Center. No. 11 , Beijing 100044 , China Department of Pathology, Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School, Nanjing, China; Key Laboratory of Organosilicon Chemistry and Material Technology of Ministry of Education; Hangzhou Normal University; Hangzhou 311121; P. R. China Guangzhou Institutes of Biomedicine and Health Chinese Academy of Sciences Guangzhou China. Correspondence: Ling Chen ([email protected]); State Key Laboratory of Respiratory Diseases Institute of Respiratory Diseases, Guangzhou College of Medicine Guangzhou China Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China Department of Respiratory and Critical Care Medicine, Ruijin Hospital North, Shanghai Jiaotong University School of Medicine, Shanghai 201821, P.R. China Department of Neurology, National Key Clinical Department and Key Discipline of Neurology, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, Guangdong is Assistant Professor of Biostatistics at Washington University in St. Louis School of Medicine, St. Louis, Missouri. Email: [email protected]. 1Zhejiang University Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, Guangzhou, PR China Department of Neurology, The First Affiliated Hospital, Sun Yet-Sen University, Guangzhou, China Cancer Pharmacology, Dana–Farber Cancer Institute, Harvard Medical School, Boston, MA 02115; and Samuel C. Johnson Medical Research Building, Mayo Clinic, Scottsdale, AZ 85259 Department of Oncology, the First Affiliated Hospital of Xi’an Jiaotong University, 766 West Yantan Road, Xi’an, 710061, China Department of Neurosurgery The First Medical Center Chinese PLA General Hospital Beijing China Department of Physiology, University of Maryland School of Medicine, Baltimore, Maryland;; Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland; Department of Mechanical Engineering, City University of Hong Kong, Hong Kong, 999077, China State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, China State Key Lab of Reproductive Medicine Nanjing Medical University Nanjing 210029 China; Department of Physiology Nanjing Medical University Nanjing 210029 China; Department of Biochemistry Nagoya University Graduate School of Medicine, 65 Tsurumai Nagoya 466‐8550 Japan Division of Biostatistics Department of Gynecology and Obstetrics, Fujian Medical University Union Hospital, Fuzhou, Fujian 350001, P.R. China Department of Microbiology, The University of Hong Kong, Hong Kong Special Administration Region, Hong Kong; State Key Laboratory of Emerging Infectious Diseases, The University of Hong Kong, Hong Kong Special Administration Region, Hong Kong; Research Centre of Infection and Immunology, The University of Hong Kong, Hong Kong Special Administration Region, Hong Kong; Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 501663, China; and Department of Biochemistry, The... Evidence-Based Medicine Center, MOE Virtual Research Center of Evidence-based Medicine at Zunyi Medical College; Affiliated Hospital of Zunyi Medical College; Zunyi China; Department of Respiratory Medicine (Center for Evidence-Based and Translational Medicine of major infectious diseases); Affiliated Hospital of Zunyi Medical College; Zunyi China Department of Geriatric Cardiology, The First Affiliated Hospital of China Medical University, Shenyang, Liaoning 110001, P.R. China Department of Geriatrics and National Clinical Research Center for Geriatrics West China Hospital of Sichuan University Chengdu China Center for Molecular Imaging and Nuclear Medicine School for Radiological and Interdisciplinary Sciences (RAD‐X) Soochow University Suzhou 215123 China; Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions Suzhou 215123 China State Key of Pollution Control and Resource Reuse, Tongji University, Shanghai, China. Department of Endodontics, Suzhou Stomatological Hospital. Suzhou 215005;China. E-mail:[email protected]. for the Diabetes Prevention Program Research (DPPOS) Group School of Chemical Engineering The University of Adelaide Adelaide SA 5005 Australia Development and Utilization Key Laboratory of Northeast Plant Materials, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China Institute of Clinical Medicine The First Affiliated Hospital of the University of South China Hengyang Hunan China Department of Neurology, The First Affiliated Hospital, Sun Yat-Sen University, 58 Zhongshan Road II, Guangzhou, 510080, P. R. China Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences , Guangzhou 510530, P. R. China; State Key Laboratory of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University , Guangzhou 510120, P. R. China Key Laboratory of Synthetic and Biological Colloids, Ministry of Education, Jiangnan University, Wuxi 214122, China; School of Food Science and Technology, Jiangnan University, Wuxi 214122, China Department of Rehabilitation Medicine, Guangdong Engineering and Technology Research Center for Rehabilitation Medicine and Translation, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China Department of Medical Quality Control, The Fifth Affiliated Hospital of Sun Yat-Sen University, Zhuhai, Guangdong, China Departments of 1Medicine and; Physiology, University of Maryland, Baltimore, Baltimore, Maryland; Beijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing Ophthalmology & Visual Science Key Lab, Beijing, China. Department of Thyroid and Breast Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, Fujian 350000, P.R. China Cancer Research Institute, Key laboratory of Chinese Ministry of Education, Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, PR China From the Departments of Physiology (M.P.B., J.Z., H.S., H.R., S.P.K., M.I., W.G.W., J.M.H.) and Medicine (M.P.B., L.C.) and the Center for Heart, Hypertension, and Kidney Disease (M.P.B., J.Z., H.S., H.R., S.P.K., M.I., W.G.W., J.M.H.), University of Maryland School of Medicine, Baltimore; the Department of Pharmacology (T.I.), Fukuoka University School of Medicine, Fukuoka, Japan; the Department of Biomedical Sciences (M.I.K.), College of Veterinary Medicine, Cornell University, Ithaca, NY; the... Guangzhou Institutes of Biomedicine and HealthChinese Academy of Sciences, Guangzhou 510530, Guangdong, China Ministry of Education Engineering Research Center of Starch & Protein Processing, College of Light Industry and Food Sciences, South China University of Technology, Guangzhou 510640, China Department of Pulmonary and Critical Care Medicine, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China;; Laboratory of Pulmonary Immunology and Inflammation, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China;; Clinical Research Center for Respiratory Disease, West China Hospital, Sichuan University, Chengdu, Sichuan, P.R. China; Department of Endocrinology (H.C., H.R., H.H., J.L., L.Li, X.G., S.P., M.L., L.C., K.T., L.Lin, P.Z., F.L., J.W., G.C.), Fujian Provincial Hospital, Fujian Medical University, Fuzhou, 350001, China Washington University School of Medicine, Department of Medicine, St. Louis Missouri, USA Molecular Sciences and Candidate Optimization, Neuroscience Biology, Bristol-Myers Squibb Research & Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States State Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine Guangzhou Institutes of Biomedicine and Health (GIBH) Chinese Academy of Sciences Guangzhou 511400 China Department of Obstetrics & Gynecology, The Affiliated Hospital of Jiangnan University, Wuxi 214062, China Department of Ophthalmology and Vision Science, the Eye, Ear, Nose and Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, China; Key Laboratory of Myopia of State Health Ministry, the Eye, Ear, Nose and Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, China; Shanghai Key Laboratory of Visual Impairment and Restoration, the Eye, Ear, Nose and Throat Hospital, Shanghai Medical College, Fudan University, Shanghai, China Key Lab of Tea Science of Ministry of Education, Hunan Agricultural University, Changsha, Hunan 410128, China; National Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients, Hunan Agricultural University, Changsha 410128, China School of Materials Science and Engineering, Fujian University of Technology, Fuzhou 350108, China; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, Fujian 361005, China School of Materials Science and Engineering; South China University of Technology; Guangzhou 510640; China Department of Otorhinolaryngology Head and Neck Surgery, Guangzhou First People’s Hospital, the Second Affiliated Hospital of South China University of Technology, Guangzhou, Guangdong Province, China Key Laboratory of Coastal Zone Environmental Processes, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China; University of Chinese Academy of Sciences, Beijing 100049, China Authors' Affiliations: 1Institute of Gastroenterology, Southwest Hospital and 2Institute of Combined Injure, College of Preventive Medicine, Third Military Medical University; 3School of Life Science, Southwest University, Chongqing, People's Republic of China Department of Neurology, First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, Guangdong, China From the Center for Vascular and Inflammatory Disease (S.C.M., S.B., B.H., M.M., I.M., D.K.S.), Departments of Physiology (S.C.M., L.C., I.M., D.K.S.), Surgery (S.B., B.H., M.M., D.K.S.), Pathology (T.C.), and Medicine (L.C.), University of Maryland School of Medicine, Baltimore, MD. Shanghai Engineering Research Center of Hierarchical Nanomaterials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, Shanghai 200237, China Department of Radiotherapy, Changzhou Tumor Hospital, Soochow University, Changzhou - China Institute of Materials Research and Engineering, 3 Research Link, Singapore 117602, Republic of Singapore and Division of Bioengineering, Faculty of Engineering, National University of Singapore, Singapore 117576, Republic of Singapore Department of Clinical Laboratory, Jiangyou People's Hospital, Sichuan. Department of Clinical Pharmacy, Key Laboratory of Clinical Cancer Pharmacology and Toxicology Research of Zhejiang Province, Affiliated Hangzhou First People's Hospital Zhejiang University School of Medicine Hangzhou China Department of Medical and Bioengineering Science, Okayama University Graduate School of Natural Science and Technology, Okayama, Japan; Department of Pathology, Tiajin Central Hospital of Gynecology Obstetrics, Tianjin, People's Republic of China Department of Pharmacy, Xindu District People’s Hospital of Chengdu, Chengdu, 610500 Sichuan, China Southern Crop Protection and Food Research Centre Agriculture and Agri‐Food Canada London ON Canada School of Chemical Engineering and Advanced Materials The University of Adelaide South Australia 5005 Australia Outpatient emergency treatment, Xixi branch of Zhejiang university hospital , Zhejiang , China Department of Neurology The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Neurology Chongqing 400016 China Department of Instrument Science and Engineering School of Electronic Information & Electrical Engineering Shanghai Jiao Tong University Shanghai P. R. China Department of Gastrointestinal Surgery Xiangya Hospital Central South University Changsha China Department of Neurosurgery, General Hospital of PLA, Beijing, P.R. China School of Materials Science and Engineering; University of Jinan; Jinan 250022; China Department of Oncology, The First Affiliated Hospital of Xi’an Jiaotong University, 277 West Yanta Road, Xi’an, Shaanxi, 710061, P.R. China Department of Pathology, Tianjin Central Hospital of Gynecology Obstetrics, Tianjin 300100, China Department of Neurosurgery, The First Medical Center of Chinese People's Liberation Army General Hospital, Beijing 100853, China University of Michigan ‐ Shanghai Jiao Tong University Joint Institute Shanghai Jiao Tong University Shanghai China Department of Dermatology Institute of Battle Surgery Daping Hospital, Third Military Medical University Chongqing China State Key Laboratory of Respiratory Disease, Guangdong Laboratory of Computational Biomedicine, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou, People’s Republic of China; Guangzhou Institute of Infectious Disease, Guangzhou Eighth People's Hospital, Guangzhou Medical University, Guangzhou, People’s Republic of China; Guangzhou National Laboratory, Guangzhou, People’s Republic of China Key Laboratory of Special Energy Materials, Ministry of Education, Nanjing University of Science and Technology, Nanjing 210094, Jiangsu, China Immunology and Reproduction Biology Laboratory & State Key Laboratory of Analytical Chemistry for Life Science, Medical School, Nanjing University, Nanjing, China; Jiangsu Key Laboratory of Molecular Medicine, Nanjing University, Nanjing, China Department of Ophthalmology and Visual Sciences, University of Alabama at Birmingham Heersink School of Medicine, Birmingham, Alabama;; The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology, and Chongqing Eye Institute, Chongqing, China; Medical Center for Digestive Diseases Second Affiliated Hospital Nanjing Medical University Nanjing Jiangsu China Shanghai Engineering Research Center of Hierarchical Nanomaterials Frontiers Science Center for Materiobiology and Dynamic Chemistry School of Chemical Engineering East China University of Science and Technology Shanghai 200237 China The Center of Experimental Teaching Management, Chongqing Medical University, Chongqing, 401331, People’s Republic of China Jiangsu Province Official Hospital, Nanjing, China. Department of Human Anatomy, Histology and Embryology School of Basic Medical Sciences Peking University Beijing China Department of Oncology, the Second Clinical College of North Sichuan Medical College, Nanchong Central Hospital, Nanchong, Sichuan, China School of Medicine, Faculty of Health, University of Tasmania, Hobart, Australia Washington University School of Medicine MSC 8502‐66‐1101, 4444 Forest Park Avenue 63108 St. Louis MO USA a Division of Biometrics VI, Office of Biostatistics, Office of Translational Sciences, Center for Drug Evaluation and Research , U.S. Food and Drug Administration , Silver Spring , Maryland , USA College of Information Engineering, Northwest A&F University, Yangling, Xianyang 712100, China Department of Respiratory Medicine, Affiliated Hospital of Zunyi Medical College, Zunyi, Guizhou, China Medical School of Ningbo University, Ningbo 315211, China. State Key Laboratory of Respiratory Disease, Guangzhou Institute of Respiratory Diseases, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers, Department of Pathology, Xijing Hospital and School of Basic Medicine Fourth Military Medical University Xi'an China State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 210029, China; Department of Physiology, Nanjing Medical University, Nanjing 210029, China Department of Plastic and Cosmetic Surgery, Maternal and Child Health Medical Institute, The Affiliated Obstetrics and Gynecology Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing 210004, China Department of Physiology, Nanjing Medical University, Nanjing, P.R. China Department of Respiratory Medicine, Affiliated Hospital of Zunyi Medical College, Zunyi, China Department of Neurology The First Affiliated Hospital of Sun Yat‐Sen University Guangzhou Guangdong China State Key Laboratory of Bioelectronics National Demonstration Center for Experimental Biomedical Engineering Education School of Biological Science and Medical Engineering Southeast University Nanjing P. R. China |
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