http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_bd6228692d5fe555f1a570226fc97512
Outgoing Links
| Predicate | Object |
|---|---|
| family-name | Zhou Jian Zhou |
| name | Jian Zhou |
| given-name | Jian |
| organization-name | Department of Materials Science and Engineering, College of Engineering, Peking University, Beijing 100871, China Polymer Materials & Engineering Department, School of Materials Science & Engineering, Chang’an University, Xi’an 710064, China National Laboratory of Solid-State Microstructures and Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing, Jiangsu 210023, China; School of Electronic Science and Engineering, Nanjing University, Nanjing, Jiangsu 210023, China Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China State Key Laboratory of Advanced Design and Manufacturing for Vehicle Body; College of Mechanical and Vehicle Engineering; Hunan University; Changsha 410082; China Department of Ophthalmology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, P.R. China Institute of Neuroscience and the Collaborative Innovation Center for Brain Science, Chongqing Medical University, Chongqing, China.; Chongqing Key Laboratory of Neurobiology, Chongqing, China. Department of Liver Surgery and Transplantation Liver Cancer Institute, Zhongshan Hospital Fudan University Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education Shanghai P. R. China; Research Unit of Liver cancer Recurrence and Metastasis, Chinese Academy of Medical Sciences Beijing P. R. China State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Science, 200032 Shanghai, China School of Materials Science and Engineering, Beihang University, Beijing, 100191, China Institute of Orthopaedics, Lanzhou General Hospital of Lanzhou Military Area Command of Chinese PLA, Lanzhou 730050, China. Department of Brain Institute, Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Epilepsy Research, Sanbo Brain Hospital, Capital Medical University, Beijing, China; Department of Neurosurgery, Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Epilepsy Research, Sanbo Brain Hospital, Capital Medical University, Beijing, China Department of Materials Science and Engineering, College of Materials, and Department of Medical Imaging, Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong Province, People's Republic of China; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University,Shanghai,China; Institute of Biomedical Sciences, Fudan University,Shanghai,China Liver Cancer Institute Zhongshan Hospital Fudan University Shanghai China School of Materials Science and Engineering, Anhui University of Technology, Ma’anshan, Anhui 243002, P. R. China Liver Surgery Department,Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of Education, and Institute of Biomedical Sciences, Fudan University,Shanghai,China Department of Cardiac Surgery, Beijing Chao-Yang Hospital, Capital Medical University, Beijing, China Imaging Diagnosis and Interventional Center, Sun Yat-sen University Cancer Center, 651 Dongfeng Rd East, Guangzhou 510060, People's Republic of China.; State Key Laboratory of Oncology in South China, Guangzhou, People's Republic of China.; Collaborative Innovation Center for Cancer Medicine, Sun Yat-sen University Cancer Center, Guangzhou, People's Republic of China. Shanghai Ultra-Precision Optical Manufacturing Engineering Center, Department of Optical Science and Engineering, Fudan University, Shanghai 200433, China Authors' Affiliations: 1Department of Molecular and Cellular Biology and Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas; and 2Luzhou Medical College, Luzhou, Sichuan 646000, China Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China College of Life Sciences Henan Normal University Xinxiang 453007 China Henan Institute of Haematology, Department of Hematology Henan Cancer Hospital Affliated Cancer Hospital of Zhengzhou University Zhengzhou China Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030; Jan and Dan Duncan Neurological Research Institute, Texas Children’s Hospital, Houston, TX 77030 Department of Integrated Emergency Dental Care and General Dentistry, Capital Medical University School of Stomatology , Beijing , China Program in Developmental Endocrinology and Genetics, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 School of Chemical and Biological Engineering, Yancheng Institute of Technology, Yancheng 224051, China and School of Materials Science and Engineering, Changzhou University, Changzhou 213100, China Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China; Key Laboratory of Medical Epigenetics and Metabolism, Institute of Biomedical Sciences, Fudan University, Shanghai, China; Shanghai Key Laboratory of Organ Transplantation, Shanghai, China Department of Physics, Clarkson University, Potsdam, New York 13676, Department of Chemistry and Biomolecular Science, Clarkson University, Potsdam, New York 13676, and Department of NanoEngineering, University of California−San Diego, La Jolla, California 92093 School of Information and Automation Engineering, Qilu University of Technology (Shandong Academy of Sciences), Jinan 250300, China Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, China. [email protected]. Department of Biomedical Engineering, Departments of Neurosurgery, Sanbo Brain Hospital, Capital Medical University , Beijing , China Department of Vaccine and Diagnostics, The Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical College Kunming Yunnan China The Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, The Chinese Ministry of Education, Shanghai, People's Republic of China Department of Thoracic Surgery, Peking University People’s Hospital, Beijing 100044, China Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 N. Zhongshan Road, Shanghai, 200062, P. R. China Department of Thoracic Surgery and Institute of Thoracic Oncology, West China Hospital Sichuan University Chengdu China Department of Burns and Plastic Surgery, Affiliated Hospital of Zunyi Medical University, Zunyi, Guizhou 563000, P.R. China Center for Craniofacial Regeneration, Columbia University Medical Center, New York, New York.; Department of General Dentistry, Capital Medical University School of Stomatology, Beijing, China. Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China; Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Ministry of Education, Shanghai, China; State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai, China Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, P. R. China; Institute of Biomedical Sciences, Fudan University, Shanghai, P. R. China Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai, China. Institute of Materia Medica, Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing 100050, China; Beijing Key Laboratory of Polymorphic Drugs, Center of Pharmaceutical Polymorphs, Beijing 100050, China Department of Vascular Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China; Department of Neurosurgery, First Affiliated Hospital of Hainan Medical College, Haikou 570102, China. Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15260, USA. State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China. [email protected] Key Laboratory of Laser & Infrared System (Shandong University) Ministry of Education Shandong University Qingdao 266237 P. R. China; Center for Optics Research and Engineering Shandong University Qingdao 266237 P. R. China Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai 200233, China Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892 School of Chemistry and Chemical Engineering Guangdong Provincial Key Laboratory for Green Chemical Product Technology South China University of Technology Guangzhou 510640 China Center for Advancing Materials Performance from the Nanoscale State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University Xi'an 710049 China Fisheries Research Institute; Sichuan Academy of Agricultural Sciences; Chengdu; China 1Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, P.R. China.; 6Institute of Biomedical Sciences, Fudan University, Shanghai, P.R. China. Jian Zhou, Lei Yu, Jie Hu, Zhi Dai, Xiaowu Huang, Zheng Wang, Shuangjian Qiu, Xiaoying Wang, Guohuan Yang, Huichuan Sun, Zhaoyou Tang, and Jia Fan, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Jian Zhou, Xue Gao, Hongguang Zhu, and Jia Fan, Institute of Biomedical Sciences, Fudan University; Jie-Fei Wang, Zhiyong Zhang, Shanghai Public Health Clinic Center; Shaohua Lu, Zhongshan Hospital, Fudan University; Ying Wu and Hongguang Zhu, Shanghai Medical College, Fudan University, Shanghai,... Third Division of Organ Transplant Center, The Eastern Hospital of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510700, P. R. China Peking Univ. People's Hospital Salivary Gland Disease Center and Molecular Laboratory for Gene Therapy and Tooth Regeneration, Capital Medical University School of Stomatology, Beijing 100050, People's Republic of China Shanghai Key Laboratory of Green Chemistry and Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P. R. China; State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, CAS, Shanghai 200032, P. R. China Center for Alloy Innovation and Design (CAID) State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University Xi'an 710049 China Gaozhou Center for Disease Control and Prevention, Gaozhou, China Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Clinical Center for Diabetes, Shanghai 200233, PR China Department of Liver Surgery and Transplantation, Liver Cancer Institute, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Zhongshan Hospital of Fudan University, Shanghai, P.R. China; Institute of Biomedical Sciences, Fudan University, Shanghai, P.R. China National Laboratory of Solid State Microstructures & Department of Materials Science and Engineering, Nanjing University, Nanjing 210093, China Fujian Provincial Key Laboratory of Screening for Novel Microbial Products, Fujian Institute of Microbiology, Fuzhou, People’s Republic of China College of Natural Resources and Environment, Northwest A&F University, Yangling, Xianyang, Shaanxi712100, P. R. China; Key Laboratory of Plant Nutrition and the Agri-environment in Northwest China, Ministry of Agriculture, No. 3 Taicheng Road, Yangling, Xianyang, Shaanxi712100, P. R. China Dongfang Hospital of Beijing University of Chinese Medicine, Beijing, China Shandong University State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, Fujian 350002, China; Key Laboratory of Green Synthesis and Applications, College of Chemistry, Chongqing Normal University, Chongqing 401331, China From the Liver Cancer Institute, Zhong Shan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai, People's Republic of China Department of Materials Science and Engineering University of California, Berkeley, California 94720, USA and Materials Sciences Division Lawrence Berkeley National Laboratory Berkeley California 94720 USA 1Department of Liver Surgery, Liver cancer Institute, Zhongshan Hospital, Fudan University, and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, P.R. China.; 3Institute of Biomedical Sciences, Fudan University, Shanghai 200032, P.R. China. The Department of Occupational and Environmental Health School of Public Health Ningxia Medical University 750004, 1160 Shengli Street, Xingqing District Yinchuan 750004 People's Republic of China National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. [email protected] College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036, China College of pharmaceutical sciences; Zhejiang University of Technology; Hangzhou 310014; P. R. China Laboratory of Clinical Pharmacy and Adverse Drug Reaction West China Hospital of Sichuan University Chengdu China; Department of Pharmacy West China Hospital of Sichuan University Chengdu China Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, P. R. China. Department of Liver Surgery, Liver Cancer Institute and Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of Education, Fudan University, Shanghai, People's Republic of China College of Chemistry Department; Chongqing Normal University; Chongqing 401331; China Key Laboratory for Harmful Components and Tar Reduction in Cigarette of Sichuan Province, Chengdu, Sichuan CN610000, China Key Laboratory of Novel Materials for Sensor of Zhejiang Province; Institute of Advanced Magnetic Materials; Hangzhou Dianzi University; Hangzhou 310018; P. R. China Physics Department Virginia Commonwealth University USA Nanjing University 2 Department of Materials Science and Engineering, , Nanjing 210093, People's Republic of China Jiangsu Province Key Laboratory of Anesthesiology & NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs Xuzhou Medical University Xuzhou City China; Department of Anesthesiology The Affiliated Hospital of Xuzhou Medical University Xuzhou City China Department of Oncology, Wuzhou Workers Hospital, Wuzhou City, 543001, China State Key Laboratory of Military Stomatology, Department of Prosthetic Dentistry, School of Stomatology, The Fourth Military Medical University, Xi'an, Shaanxi, China (mainland) Authors' Affiliations: 1Liver Cancer Institute, 2Department of Pathology, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis & Cancer Invasion, the Chinese Ministry of Education, Shanghai; 3Department of Hepatobiliary Surgery, The First Affiliated Hospital of Sun Yat-sen University, Guangzhou, PR China; and 4Division of Pharmacoproteomics, National Cancer Center Research Institute, Tokyo, Japan Department of Radiology Sun Yat‐sen University Cancer Center Guangzhou China Liver Cancer Institute Zhongshan Hospital Fudan University Shanghai Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis & Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663N Zhongshan Road, Shanghai 200062, China Lewis-Sigler Institute for Integrative Genomics, Princeton University, Princeton, NJ 08544, USA; Graduate Program in Quantitative and Computational Biology, Princeton University, Princeton, NJ 08544, USA Department of Otorhinolaryngology-Head and Neck Surgery, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, 354 Fenglin Lu, Shanghai 200032, China [email protected] Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of Education, Shanghai 200032, P.R. China The Fishery Institute of The Sichuan Academy of Agricultural Sciences, Sichuan Provincial Laboratory for Natural Resources Protection and Sustainable Utilization, Chengdu, People’s Republic of China Key Laboratory of Geochemical Exploration, Ministry of Land and Resources, Institute of Geophysical and Geochemical Exploration, Chinese Academy of Geological Sciences, Langfang 065000, China; UNESCO International Centre on Global-Scale Geochemistry, Langfang 065000, China Department of Neurosurgery The Affiliated Hospital of Southwest Medical University Luzhou China; Sichuan Clinical Research Center for Neurosurgery Luzhou China; Neurological Disease and Brain Function Laboratory The Affiliated Hospital of Southwest Medical University Luzhou China Institute for Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China; Institute for the Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, China Department of Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China 2Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University; and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, P.R. China.; 8Institute of Biomedical Sciences, Fudan University, Shanghai, P.R. China. College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi Province 712100, PR China; Key Laboratory of Plant Nutrition and the Agri-environment in Northwest China, Ministry of Agriculture, Yangling, Shaanxi 712100, PR China College of Chemical Engineering Zhejiang University of Technology Zhejiang China Shanghai Key Laboratory of Green Chemistry and Chemical Processes, East China Normal University, Shanghai, 200062, P. R. China, and Shanghai Key Laboratory of Magnetic Resonance, Department of Physics, Shanghai 200062, P. R. China Department of Cardiovascular Medicine,Heart Center, First Affiliated Hospital of Wenzhou Medical University,Wenzhou,China Physics Department; Virginia Commonwealth University; Richmond, USA Department of Gerontology, The First Affiliated Hospital of University of Science and Technology of China, Hefei, Anhui 230001, P.R. China College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi Province 712100, P. R. China State Key Laboratory of Radiation Medicine and Protection, School of Radiation Medicine and Protection, Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Soochow University, Suzhou, China School of Textile and Fiber Engineering and School of Chemistry and Biochemistry, Georgia Institute of Technology, Atlanta, Georgia 30332 School of Energy Sciences and Engineering, Nanjing Tech University, Nanjing, 211816 Jiangsu, P.R. China State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China; Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang 330006, China MOE Key Laboratory of Tumor Molecular Biology Key Laboratory of Functional Protein Research of Guangdong Higher Education Institutes Institute of Life and Health Engineering The First Affiliated Hospital Jinan University Guangzhou Guangdong China Department of Biochemistry and Molecular Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. Department of Radiology Taian City Central Hospital Tai China West China Medical School/West China Hospital, Sichuan University, Chengdu, Sichuan Province 610041, P.R. China Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China Contraceptives Adverse Reaction Surveillance Center of National Health Commission Nanjing China; Jiangsu Health Development Research Center Nanjing China Department of Geriatrics Beijing Tongren Hospital, Capital Medical University Beijing China Department of Animal Genetics, Breeding, and Reproduction, National Engineering Research Center for Breeding Swine Industry, College of Animal Science South China Agricultural University Guangzhou China Department of Liver Surgery and Transplantation,Liver Cancer Institute,Zhongshan Hospital,Fudan University,Shanghai,China; Key Laboratory of Carcinogenesis and Cancer Invasion,Ministry of Education,Fudan University,Shanghai,China; Institute of Biomedical Sciences,Fudan University,Shanghai,China; Shanghai Key Laboratory of Organ Transplantation,Zhongshan Hospital,Fudan University,Shanghai,China; State Key Laboratory of Genetic Engineering,Fudan University,Shanghai,China Department of Neurosurgery, SanBo Brain Hospital, Capital Medical University , Beijing 100093 , China Department of Liver Surgery and Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China Department of Biomedical Engineering Department of Urology, University of Texas Southwestern Medical Center at Dallas, Dallas, Texas Medical Center for Digestive Diseases Second Affiliated Hospital, Nanjing Medical University Nanjing China Department of Chemistry and Key Laboratory of Organic Synthesis of Jiangsu Province, Suzhou University, Suzhou 215123, People’s Republic of China, and Department of Chemistry and Biology, Yulin Normal University, Yulin 537000, People’s Republic of China Department of Dermatology Xijing Hospital, Fourth Military Medical University Xi'an P. R. China Department of Medical Imaging Sun Yat‐Sen University Cancer Center Guangzhou Guangdong China Department of Nuclear Science and Engineering Massachusetts Institute of Technology Cambridge MA 02139 USA Shanghai Key Laboratory of Green Chemistry and Chemical Processes; Department of Chemistry; School of Chemistry and Molecular Engineering; East China Normal University; Shanghai 200241 Department of Otolaryngology–HNS, Eye, Ear, Nose and Throat Hospital, Shanghai Key Clinical Disciplines of Otorhinolaryngology, Fudan University School of Medicine, Shanghai, PR China;; Department of Pudong Hospital, Fudan University School of Medicine, Shanghai, PR China; State Key Laboratory of Green Chemical Engineering and Industrial Catalysis, Shanghai Research Institute of Petrochemical Technology, SINOPEC, China Shanghai Key Clinical Disciplines of Otorhinolaryngology, Department of Otorhinolaryngology, Eye, Ear, Nose, and Throat Hospital, Fudan University, Shanghai, China Department of Integrated Emergency Dental Care and General Dentistry, Capital Medical University School of Stomatology, Beijing, PR China Centre of Cardiology, Xinqiao Hospital of Third Military Medical University, Chongqing 400037, China. Organ Transplantation Center, the First Affiliated Hospital of Sun Yat-sen University, Guangzhou 510080, China. Department of Pathophysiology, College of High Altitude Military Medicine, Third Military Medical University, Chongqing 400038, P.R. China Institute of Orthopaedics, Lanzhou General Hospital, Lanzhou Command of PLA, Lanzhou, Peopleʼs Republic of China College of Chemical Engineering; Zhejiang University of Technology; Zhejiang China; Lab of Physicochemical Research, Department of Physicochemical & Toxicology; Zhejiang Provincial Center for Disease Control and Prevention; Zhejiang China National University of Defense Technology Liver Cancer Institute Fudan University Zhongshan Hospital Shanghai China Reproductive Medicine Center, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, P.R. China Liver Cancer Institute Zhongshan Hospital and Shanghai Medical School, Fudan University Key Laboratory for Carcinogenesis & Cancer Invasion The Chinese Ministry of Education Shanghai People's Republic of China Beijing University of Technology University of Cincinnati 1 BioMicroSystems Lab, Department of Electrical Engineering and Computing Systems, , Cincinnati, Ohio 45221, USA Department of Otolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai 200031, P.R. China Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, People’s Republic of China Institute of Orthopaedics Lanzhou General Hospital of CPLA Lanzhou China Portland, Oregon 97201; the Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health (J.Z., C.A.B.), Bethesda, Maryland 20892 Department of Pathology, Anatomy, and Cell Biology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA. State Key Laboratory of High Performance Ceramic and Superfine Microstructures, Shanghai Institute of Ceramics, Chinese Academy of Science, Shanghai 200050, China Tribology Research Institute School of Mechanical Engineering Southwest Jiaotong University Chengdu 610031 P. R. China From the Department of Ophthalmology, Xijing Hospital, and Department of Radiology, Taian City Central Hospital, Taian, China Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China Department of Pulmonary Medicine Zhongshan Hospital Fudan University Shanghai China [email protected] Department of Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai 200032, China. [email protected] Department of Chemistry and Biomolecular Science and NanoBio Laboratory, Clarkson University, Potsdam, New York 13699-5810 Xi’an Modern Control Technology Research Institute Biotechnology Research Institute, Chinese Academy of Agricultural Sciences, Beijing, China. Laboratory of Clinical Pharmacy and Adverse Drug Reaction, West China Hospital of Sichuan University, Chengdu 610041, China; Department of Pharmacy, West China Hospital of Sichuan University, Chengdu 610041, China College of Natural Resources and Environment, Northwest A&F University, Yangling, Shanxi 712100, P. R. China Printable Electronics Research Centre, Suzhou Institute of Nanotech and Nano-bionics, Chinese Academy of Sciences, Suzhou 215123, P.R. China Eye Institute of Chinese PLA and Department of Ophthalmology, Xijing Hospital, Air Force Medical University, Xi’an, Shaanxi, China King Abdullah University of Science and Technology (KAUST); Physical Sciences and Engineering Division; COHMAS Laboratory; Thuwal 23955-6900; Saudi Arabia School of Physics and Materials Science, Jiangxi Key Laboratory for Two-Dimensional Materials and Jiangxi Engineering Laboratory for Advanced Functional Thin Films, Nanchang University, Nanchang 330031, China Department of Ophthalmology Xijing Hospital Eye Institute of Chinese PLA Fourth Military Medical University Xi’an China Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital of Fudan University Shanghai China; Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education Shanghai China; State Key Laboratory of Genetic Engineering Fudan University Shanghai China; Shanghai Key Laboratory of Organ Transplantation Zhongshan Hospital, Fudan University Shanghai China; Institute of Biomedical Sciences, Fudan University Shanghai China Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Department of Endocrinology and Metabolism, The Sixth People's Hospital, Affiliated to Jiaotong University, Shanghai 200233, China. China Military Institute of Chinese Materia Medica, 302 Military Hospital of China, Beijing. Department of Endocrinology and Metabolism Shanghai Diabetes Institute Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai Clinical Center of Diabetes Shanghai Diabetes Institute Shanghai Key Laboratory of Diabetes Mellitus Shanghai China Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 200233, China Key Laboratory of Carcinogenesis of Chinese Ministry of Public Health Liver Cancer Institute Zhongshan Hospital Shanghai China State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People’s Republic of China Physical Sciences and Engineering Division (PSE), COHMAS Laboratory, King Abdullah University of Science and Technology (KAUST), Thuwal 23955-6900, Saudi Arabia Key Laboratory of Green Synthesis and Applications; College of Chemistry; Chongqing Normal University; Chongqing; P. R. China Liver Cancer Institute, Fudan University, Shanghai 200032, China. School of Horticulture and Landscape Architecture, Henan Institute of Science and Technology , No. 90 Hualan Road, Hongqi District, Xinxiang, Henan Province 453003 , China; Henan Province Engineering Center of Horticulture Plant Resource Utilization and Germplasm Enhancement , No. 90 Hualan Road, Hongqi District, Xinxiang, Henan Province 453003 , China Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, People’s Republic of China Department of Radiology Sun Yat‐Sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou P. R. China Department of Otolaryngology HNS Eye Ear Nose and Throat Hospital Fudan University School of Medicine Shanghai China Department of General Dentistry and Emergency Dental Care Beijing Stomatological Hospital Capital Medical University Beijing China Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Ministry of Education, Shanghai 200032, China Department of Endocrinology and Metabolism Shanghai Sixth People's Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus Shanghai China Shanghai Key Laboratory of Green Chemistry and Chemical Processes, East China Normal University, 3663 N. Zhongshan Road, Shanghai, 200062, P. R. China Department of Chemistry Hong Kong Baptist University Kowloon, Hong Kong China; Department of Chemistry Southern University of Science and Technology Shenzhen Guangdong, 518055 China State Key Laboratory of Natural and Biomimetic Drugs and School of Pharmaceutical Sciences, Peking University, Xue Yuan Road No. 38, Beijing 100191, China, and Department of Biochemistry, Glycobiology Institute, University of Oxford, South Parks Road, Oxford OX1 3QU, U.K. Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China; Institute of Biomedical Sciences, Fudan University, Shanghai, China; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China; Shanghai Key Laboratory of Organ Transplantation, Shanghai, China. State Key Laboratory of Chemical Engineering College of Chemical and Biological Engineering Zhejiang University Hangzhou 310027 China Liver Surgery Department, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China Peking University 1 Department of Advanced Materials and Nanotechnology, , Beijing 100871, China Department of Paediatric Laboratory, The Affiliated Wuxi Children's Hospital of Nanjing Medical University Wuxi 214023, Jiangsu, China. South China University of Technology 1 Guangdong Provincial Key Lab for Green Chemical Product Technology, School of Chemistry and Chemical Engineering, , Guangzhou, Guangdong 510640, People’s Republic of China College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, P. R. China School of Chemistry and Chemical Engineering, Guangdong Provincial Key Laboratory for Green Chemical Product Technology, South China University of Technology, Guangzhou 510640, P. R. China Department of Neurosurgery, Epilepsy Center, Sanbo Brain Hospital Capital Medical University Beijing China; Beijing Key Laboratory of Epilepsy, Sanbo Brain Hospital Capital Medical University Beijing China Department of Occupational and Environmental Health, School of Public Health and Management Ningxia Medical University Yinchuan China; Key Laboratory of Environmental Factors and Chronic Disease Control, School of Public Health and Management Ningxia Medical University Yinchuan China Department of Orthopaedic Surgery Zhongshan Hospital, Fudan University Shanghai 200032 China UT Southwestern Medical Center, Dallas, Texas, United States School of Chemistry, National University of Ireland Galway, University Road, Galway, Ireland, and Centre for Synthesis and Chemical Biology & UCD School of Chemistry and Chemical Biology, University College Dublin, Dublin 4, Ireland Heart Center and Beijing Key Laboratory of Hypertension Beijing Chaoyang Hospital Capital Medical University Beijing China College of Chemistry and Chemical Engineering, Inner Mongolia Engineering and Technology Research Center for Catalytic Conversion and Utilization of Carbon Resource Molecules, Inner Mongolia University, Hohhot 010021, China Department of Liver Surgery Zhongshan Hospital Shanghai China South China University of Technology 1 Guangdong Provincial Key Lab for Green Chemical Product Technology, School of Chemistry and Chemical Engineering, , Guangzhou 510640, China State Key Laboratory of Frozen Soil Engineering, Cold and Arid Regions Environmental and Engineering Research Institute Chinese Academy of Sciences Lanzhou 730000 China Department of Radiology, Hangzhou Cancer HospitalHangzhouChina Department of Physics, Virginia Commonwealth University, Richmond, VA 23284; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences Department of Pathology, Anatomy and Cell Biology, Thomas Jefferson University, Philadelphia, PA 19107, USA. School of Materials Science and Engineering, and Center for Integrated Computational Materials Engineering, International Research Institute for Multidisciplinary Science, Beihang University, Beijing 100191, China State Key Laboratory of Chemical Engineering College of Chemical and Biological Engineering Zhejiang University Hangzhou 310027 P. R. China Developmental Endocrinology Branch, National Institute of Child Health and Development, National Institutes of Health, Bethesda, Md Department of Surgery, Changhai Hospital Second Military Medical University Shanghai China Department of Liver Surgery and Transplantation and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education) Liver Cancer Institute Zhongshan Hospital Fudan University Shanghai China; Institutes of Biomedical Sciences Fudan University Shanghai China Department of Respiratory Medicine Guangzhou Medical University Second Affiliated Hospital Guangzhou China Liver Cancer Institute, Zhongshan Hospital, Fudan University Shanghai China; State Key Laboratory of Genetic Engineering Fudan University Shanghai China; Key Laboratory of Carcinogenesis and Cancer Invasion Fudan University, Ministry of Education Shanghai China College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi 712100, P. R. China Affiliated Hospital of Chengde Medical University, Chengde 067000, China. [email protected]. Department of Radiology, Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou, China Liver Surgery Department,Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of Education,Shanghai,China; Institute of Biomedical Sciences,Fudan University,Shanghai,China Department of Cardiac Surgery, Beijing Chaoyang Hospital, Capital Medical University, Ministry of Education Special Steel Department of Central Iron and Steel Research Institute (CISRI), Beijing 100081, China Chengdu University of TCM, Chengdu 610075, China. [email protected] Organ Transplant Center; The First Affiliated Hospital; Sun Yat-sen University; Guangzhou China School of Energy Sciences and Engineering Nanjing Tech University 211816 Nanjing Jiangsu Province China School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, P.R. China National Laboratory of Solid State Microstructures Jiangsu Key Laboratory of Artificial Functional Materials College of Engineering and Applied Science Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjing 210093 China Shandong Marine Forecast and Hazard Mitigation Service, Qingdao 266104, Shandong,China. Department of Thyroid and Breast Surgery, Jiangsu Taizhou People’s Hospital, Taizhou, Jiangsu, China Gaozhou Center for Disease Control and Prevention, Maoming, Guangdong 525000, China University of Washington Department of Chemical Engineering, , Seattle, Washington 98195 Department of Bioengineering, Biomedical Science Tower 3-5059, 3051 Fifth Avenue, University of Pittsburgh, Pittsburgh, PA 15261, USA. School of Materials Science and Engineering, and Center for Integrated Computational Materials Science, International Research Institute for Multidisciplinary Science, Beihang University, 100191 Beijing, People’s Republic of China Department of Liver Surgery and Transplantation, Liver Cancer Institute, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Zhongshan Hospital, Fudan University, Shanghai, China Department of Vascular Surgery, Changhai Hospital, Navy Medical University, Shanghai 200433, P. R. China Department of Hepatobiliary Surgery, The Second Affiliated Hospital of Kunming Medical University, Kunming 650101, China Institute of Orthopaedics, Lanzhou General Hospital, Lanzhou 730050, China. Department of Orthopedics, The Second Xiangya Hospital; Department of Sports Medicine Research Center, Central South University, Changsha, Hunan Halophyte Research Laboratory, Nanjing University, Nanjing 210093, China. [email protected] Department of Hematology, The Third People's Hospital of Chengdu, Chengdu 610031, Sichuan Province, China. Molecular Laboratory for Gene Therapy and Tooth Regeneration, Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction Capital Medical University School of Stomatology, Beijing, People’s Republic of China Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha 410011, Hunan, China Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, China; Department of Chemistry, Southern University of Science and Technology (SUSTech), Shenzhen, 518055, China; Department of Chemistry, Hong Kong Baptist University, Kowloon, Hong Kong, China Department of Neurosurgery, Affiliated Hospital of Southwest Medical University, Luzhou 646000, China. Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Ministry of Education, Shanghai, China; State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China; Shanghai Key Laboratory of Organ Transplantation, Zhongshan Hospital, Fudan University, Shanghai, China; Institute of Biomedical Sciences, Fudan University, Shanghai, China Liver Cancer Institute Zhongshan Hospital Fudan University and Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education Shanghai People's Republic of China Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, P. R. China; Institute of Biomedical Sciences, Fudan University, Shanghai, P. R. China Department of Urology, The Fourth Affiliated Hospital of Nantong Medical College, Yancheng City No. 1 People's Hospital, Yancheng 224001, P.R. China State Key Laboratory of Materials-oriented Chemical Engineering, Nanjing University of Technology, Nanjing 210009, People’s Republic of China, School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, People’s Republic of China, and Department of Chemical Engineering, University of Washington, Seattle, Washington 98195 Department of Pulmonary and Critical Care Medicine Zhongshan Hospital Fudan University Shanghai China; Shanghai Engineer and Technology Research Center of Internet of Things for Respiratory Medicine Shanghai China; Shanghai Key Laboratory of Lung Inflammation and Injury Shanghai China; Shanghai Respiratory Research Institution Shanghai China The Second Affiliated Hospital, School of Medicine, Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People's Hospital Southern University of Science and Technology Shenzhen Guangdong Province China Department of General Surgery, Huashan Hospital, Fudan University, Shanghai, 200040, China School of Chemistry and ‡School of Natural Sciences, National University of Ireland, Galway, Ireland Sports Social Science Research Center, Shenyang Sport University, Shenyang, Liaoning, China Department of Chemistry and Chemical Biology, Harvard University, Cambridge, Massachusetts 02138 Department of Pulmonary Medicine, Zhongshan Hospital Fudan University Shanghai China; Chinese Alliance Against Lung Cancer China; Shanghai Respiratory Research Institution Shanghai China Tumor Hospital Affiliated to Xinjiang Medical University Xinjiang Uygur Autonomous Region Urumqi P.R. China; State Key Laboratory of Pathogenesis, Prevention Treatment of Central Asian High Incidence Diseases Xinjiang Uygur Autonomous Region Urumqi P.R. China School of Materials Science and Engineering and ‡Center for Integrated Computational Materials Engineering, International Research Institute for Multidisciplinary Science, Beihang University, Beijing 100191, China Department of Otorhinolaryngology, Fudan University, Eye Ear Nose and Throat Hospital, Shanghai, China; Department of Medical Imaging Center, State Key Laboratory of Oncology in South China, Collaborate Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Sun Yat‐sen University Cancer Center Guangzhou China Physics Department Virginia Commonwealth University 701 W Grace St Richmond VA 23284-2000 USA Institute of Biomedical Sciences Fudan University Shanghai People's Republic of China; Department of Liver Surgery and Transplantation, Liver Cancer Institute Zhongshan Hospital Fudan University Shanghai People's Republic of China; Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University) Ministry of Education Shanghai People's Republic of China Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, China. State Key Laboratory of Chemical Engineering; College of Chemical and Biological Engineering; Zhejiang University; Hangzhou 310027; China Department of Neurosurgery, Jinling Hospital, Jinling Clinical Medical College, Nanjing Medical University Nanjing 210002, Jiangsu Province, China. Department of Neurosurgery, The First Affiliated Hospital of Hainan Medical College Haikou 570102, Hainan Province, China. State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences, Beijing Institute of Lifeomics, Beijing, China. Department of Chemistry and Key Laboratory of Organic Synthesis of Jiangsu Province, Suzhou University, Suzhou 215006, People's Republic of China, and State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, People's Republic of China Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, People's Republic of China; Institutes of Biomedical Sciences, Fudan University, Shanghai, People's Republic of China Department of Hematology, Affiliated Cancer Hospital of Zhengzhou University, Henan Cancer Hospital, Zhengzhou 450003, China. Department of Radiology Sun Yat‐sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy Guangzhou Guangdong People's Republic of China Lanzhou General Hospital of Lanzhou Military Area Command of Chinese PLA, Lanzhou, China. Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of Sciences Qingdao 266101 China; University of Chinese Academy of Sciences Beijing 100049 China Department of General Surgery The First Affiliated Hospital of Soochow University Suzhou China University of Konstanz Universitätsstraße 10 78457 Konstanz Germany Liver Cancer Institute, Liver Surgery Department, Zhongshan Hospital Department of Neurosurgery, Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Epilepsy Research, Sanbo Brain Hospital Capital Medical University Beijing 100093 China Liver Cancer Institute, Zhongshan Hospital Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education Shanghai 200032 People's Republic of China; Institutes of Biomedical Science Fudan University Shanghai 200032 People's Republic of China State Key Laboratory of Oncology in South China Department of Medical Imaging Collaborative Innovation Center for Cancer Medicine Sun Yat‐sen University Cancer Center Guangzhou 510060 China Organ Transplantation Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510080, China. [email protected] Department of Functional Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, P.R. China State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China Inner Mongolia University State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, School of Life Sciences, , Hohhot 010021, China; Inner Mongolia Wesure Date Technology Co., Ltd. Digital College, Inner Mongolia Intelligent Union Big Data Academy, , Hohhot 010010, China Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes Shanghai China Department of Burn and Reconstruction The First Affiliated Hospital of Zhengzhou University Zhengzhou 450002 China Liver Cancer Institute Zhongshan Hospital Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University Shanghai China; Institute of Biomedical Sciences Fudan University Shanghai China Department of Anesthesiology The Affiliated Hospital of Xuzhou Medical University Jiangsu Province Xuzhou City China; Jiangsu Province Key Laboratory of Anesthesiology & NMPA Key Laboratory for Research and Evaluation of Narcotic and Psychotropic Drugs Xuzhou Medical University Jiangsu Province Xuzhou City China Department of Liver Surgery; Liver Cancer Institute; Zhongshan Hospital; Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education National Laboratory of Solid State Microstructures and Department of Materials Science and Engineering; Nanjing University; Nanjing 210093; People's Republic of China Department of Human Anatomy Institute of Neuroscience Chongqing Medical University Chongqing China Department of Chemistry and Key Laboratory of Organic Synthesis of Jiangsu Province, Suzhou University, Suzhou 215006, P. R. China, and State Key Laboratory of Coordination Chemistry, Nanjing University, Nanjing 210093, P.R. China The Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, People’s Republic of China Departments of Otolaryngology-Head and Neck Surgery, Fudan University, Shanghai, China;; Shanghai Key Clinical Disciplines of otorhinolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, China; Institute of Quality Standard and Testing Technology for Agri-products, Chinese Academy of Agricultural Sciences, Beijing 100081, China; Key Laboratory of Agri-food Safety and Quality, Ministry of Agriculture, Beijing 100081, China Department of Cardio‑Thoracic Surgery, Shanghai Tenth People's Hospital, Tongji University School of Medicine, Shanghai 200072, P.R. China Weifang Center for Disease Control and Prevention, Weifang City, Shandong Province, China. Liver Cancer Institute Zhongshan Hospital Fudan University Shanghai China; Key laboratory of Carcinogenesis and Cancer Invasion Ministry of Education Shanghai China; Shanghai Key Laboratory of Organ Transplantation Shanghai China School of Polymer, Textile & Fiber Engineering, School of Chemistry and Biochemistry, and Center for Advanced Research in Optical Microscopy (CAROM), Georgia Institute of Technology, Atlanta, Georgia 30332 Southwestern Institute of Physics , Chengdu 610041, People’s Republic of China College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi Province 712100, P. R. China; Key Laboratory of Plant Nutrition and the Agri-environment in Northwest China, Ministry of Agriculture, Yangling, Shaanxi 712100, P. R. China Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, China; Pancreatic Disease Research Center, The First Affiliated Hospital of Soochow University, Suzhou, China Shanghai Key Laboratory of Green Chemistry and Chemical Process; School of Chemistry and Molecular Engineering; East China Normal University; Shanghai 200062; P. R. China Department of Vascular Surgery the First Affiliated Hospital of the Navy Medical University Shanghai China National Laboratory of Solid State Microstructures and Department of Physics, Nanjing University, Nanjing, 210093, China, Department of Chemistry and Nebraska Center for Materials and Nanoscience, University of Nebraska, Lincoln, Nebraska 68588 The Outreach Department of Certification with World Health Organization Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College Kunming China School of Chemistry and Chemical Engineering; South China University of Technology; Guangdong Provincial Key Lab for Green Chemical Product Technology and State Key Lab of Pulp and Paper Engineering; Guangzhou 510640; China From the Department of Radiology (R.P., J.A.A., P.G., M.S.G.), Druckenmiller Center for Lung Cancer Research (R.P., K.S.T., N.R., M.S.G., D.R.J.), Thoracic Surgery Service (J.G.C., R.C., J.Z., D.R.J.), Biostatistics Service, Department of Epidemiology and Biostatistics (K.W., K.S.T.), and Department of Pathology (N.R.), Memorial Sloan Kettering Cancer Center, 1275 York Ave, Box 7, New York, NY 10065. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai, People's Republic of China. School of Resources and Safety Engineering Central South University Changsha China Department of Vascular Surgery, Changhai Hospital, Shanghai, China; The first three authors contributed equally to this paper. Department of Surgery, First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou City, Zhejiang Province 310006, China Department of Geriatrics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, China; Department of Geriatrics, Wannan Medical College, Wuhu, Anhui, China Center for Wound Healing and Tissue Regeneration College of Dentistry, University of Illinois at Chicago Chicago Illinois Department of Orthopedics, Beijing Shijitan Hospital Capital Medical University Beijing China Institute for Anhui Province Key Laboratory of Major Autoimmune Diseases, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, China;; Institute for the Key Laboratory of Anti-inflammatory and Immune Medicines, Ministry of Education, Hefei, China Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China; Institute of Biomedical Sciences, Fudan University, Shanghai, China Medical Centre for Digestive Diseases The Second Affiliated Hospital of Nanjing Medical University Nanjing China School of Environmental Science and Technology, Suzhou University of Science and Technology, Suzhou 215009, China. Institute of Environmental Biotechnology, Suzhou University of Science and Technology, Suzhou 215009, China. 1Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital and Thoracic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming 650118, China. Department of Pulmonary Medicine Zhongshan Hospital Fudan University, Shanghai Respiratory Research Institute Shanghai China Department of Endocrinology and Metabolism and Shanghai Clinical Center for Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Diabetes Institute, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai, China. 1Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, P.R. China.; 3Institute of Biomedical Sciences, Fudan University, Shanghai 200032, P.R. China. Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development Shanghai Key Laboratory of Green Chemistry and Chemical Process East China Normal University Shanghai 200062 China; Key Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education Hainan Normal University Haikou 571158 China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China Department of Pathophysiology, Third Military Medical University, Chongqing, PR China; Department of Cell Biology, Third Military Medical University, Chongqing, PR China National Key Laboratory of Materials for Integrated Circuits Shanghai Institute of Microsystem and Information Technology Chinese Academy of Science Shanghai China Department of Gerontology The First Affiliated Hospital of University of Science and Technology of China, Division of Life Sciences and Medicine, University of Science and Technology of China Hefei Anhui China Laboratory of Image Science and Technology , Southeast University, Nanjing, China Beijing Key Laboratory of Magnetic Resonance Imaging and Brain Informatics Beijing China Developmental Endocrinology BranchNICHDNational Institutes of Health Bethesda Maryland 20892 USA Center of Cardiology, Shanghai East Hospital Tongji University School of Medicine Shanghai China Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, 600 Yishan road, Shanghai 200233, China Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Sixth People's Hospital, Jiaotong University, Shanghai Diabetes Institute, Shanghai 200233, China. Department of Functional Neurosurgery, Sanbo Brain Hospital, Capital Medical University, Beijing, China Department of Liver Surgery, Zhongshan Hospital, Fudan University, Shanghai, China Vaccine Technology and Process Research Center, Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College, Kunming, China Institute of Orthopaedics, Lanzhou General Hospital of CPLA Lanzhou China State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, 38 Zheda Road, Hangzhou 310027, China; Institute of Zhejiang University─Quzhou, 78 Jiuhua Boulevard North, Quzhou 324000, China Department of Liver Surgery and Transplantation Liver Cancer Institute, Zhongshan Hospital Fudan University Shanghai China; Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of Education Shanghai China; Institutes of Biomedical Sciences Fudan University Shanghai China; Shanghai Key Laboratory of Organ Transplantation Shanghai China; State Key Laboratory of Genetic Engineering Fudan University Shanghai China Authors' Affiliations: 1Liver Cancer Institute; 2Shanghai Key Laboratory of Organ Transplantation; 3Department of Pathology, Zhong Shan Hospital, Fudan University; and 4Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China; Authors' Affiliations: 1Liver Cancer Institute; 2Shanghai Key Laboratory of Organ Transplantation; 3Department of Pathology, Zhong Shan Hospital, Fudan University; and 4Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai, China Department of Neurosurgery, Center of Epilepsy, Sanbo Brain Hospital, Capital Medical University, Haidian District, Beijing, China Department of Otorhinolaryngology, Eye, Ear, Nose and Throat Hospital of Fudan University Shanghai China School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou 510640, China School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang 621010, China; Engineering Research Center of Biomass Materials, Ministry of Education, Southwest University of Science and Technology, Mianyang 621010, China Beijing Key Laboratory for Green Catalysis and Separation and Department of Chemistry and Chemical Engineering, College of Environmental and Energy Engineering, Beijing University of Technology, Beijing 100124, P. R. China School of Energy Sciences and Engineering, Nanjing Tech University, Nanjing 211816, China Institute of Immunology of PLA,Third Military Medical University,Chongqing,China Yanshan University Key Laboratory of the Three Gorges Reservoir's Eco-Environments, Ministry of Education, Chongqing University, Chongqing 400045, China; Faculty of Urban Construction and Environmental Engineering, Chongqing University, 174 Shazheng Street, 400045 Chongqing, China Department of Urology, The Fourth Affiliated Hospital of Nantong Medical College, Yancheng, Jiangsu 224001, P.R. China 3rd Division of Organ Transplant Center, Eastern Campus of The First Affiliated Hospital, Sun Yat-sen University, Guangzhou 510700, P.R. China State Key Laboratory for Chemo/Biosensing and Chemometrics, College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, People’s Republic of China Center for Alloy Innovation and Design State Key Laboratory for Mechanical Behavior of Materials Xi'an Jiaotong University Xi'an 710049 China School of Chemistry and Chemical Engineering, Guangdong Provincial Key Lab for Green Chemical Product Technology, South China University of Technology, Guangzhou 510640, PR China Department of Gynecology, Xuzhou Maternity and Child Health Care Hospital, Xuzhou Medical University, Xuzhou, Jiangsu 221009, P.R. China Department of Vascular Surgery, Changhai Hospital, Second Military Medical University, Shanghai 200433, China Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China; Institutes of Biomedical Sciences, Fudan University, Shanghai, People's Republic of China College of Pharmacy Guizhou University of Traditional Chinese Medicine Guiyang 550025 P. R. China; Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development Shanghai Key Laboratory of Green Chemistry and Chemical Processes East China Normal University Shanghai 200062 P. R. China; State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry, CAS Shanghai 200032 P.R. China School of Chemistry and Chemical Engineering; Guangdong Provincial Key Lab for Green Chemical Product Technology; South China University of Technology; Guangzhou, P. R. China Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, China National Laboratory of Solid State Microstructures and Department of Materials Science and Engineering; Nanjing University; Nanjing 210093; P. R. China Department of Respiratory Medicine Zhongshan Hospital Fudan University Shanghai P.R. China Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular Engineering East China Normal University 3663N Zhongshan Road Shanghai 200062 China; State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 P. R. China Department of Occupational and Environmental Health, School of Public Health and Management, Ningxia Medical University, Yinchuan 750004, China Organ Transplant Centre, The First Affiliated Hospital of Sun Yat‑sen University, Guangzhou, Guangdong 510080, P.R. China Department of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of Education, Shanghai 200032, China Department of Microbiology and Immunology, Thomas Jefferson University, 1020 Locust Street, Philadelphia, PA 19107, USA Department of Liver Surgery, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Liver Cancer Institute, Zhongshan Hospital Fudan University Shanghai China; Institutes of Biomedical Sciences Fudan University Shanghai China Department of Neurosurgery, The First Affiliated Hospital of Hainan Medical College, Haikou, Hainan, P.R. China Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China; Shanghai Clinical Center for Diabetes Shanghai China; Shanghai Key Clinical Center for Metabolic Disease Shanghai China; Shanghai Diabetes Institute Shanghai China; Shanghai Key Laboratory of Diabetes Mellitus Shanghai China Department of Orthopaedics and Traumatology Nanfang Hospital Southern Medical University Guangzhou 510515 China Liver Cancer Institute and Zhongshan Hospital Fudan University 136 Yi Xue Yuan Road 200032 Shanghai People’s Republic of China; Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education 136 Yi Xue Yuan Road 200032 Shanghai People’s Republic of China Department of Radiology, Hangzhou Cancer HospitalHangzhouP.R. China Department of Liver Surgery and Transplantation Liver Cancer Institute Zhongshan Hospital Fudan University Shanghai China; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education Shanghai China; Institutes of Biomedical Sciences Fudan University Shanghai China; Shanghai Key Laboratory of Organ Transplantation Shanghai China; State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development School of Life Sciences Fudan University Shanghai China Department of Cardiology, Shanghai East Hospital Tongji University School of Medicine Shanghai People's Republic of China Department of Liver Surgery & Transplantation Liver Cancer Institute Zhongshan Hospital, Fudan University Shanghai P.R. China; Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education Shanghai P. R. China; Institutes of Biomedical Sciences Fudan University Shanghai P.R. China McKusick-Zhang Center for Genetic Medicine, State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People's Republic of China School of Chemistry and Chemical Engineering, Guangdong Provincial Key Lab for Green Chemical Product Technology, South China University of Technology, Guangzhou, Guangdong 510640, P. R. China CTIQ, Canon Medical Research USA, Inc., Vernon Hills, IL 60061 USA. College of Life Sciences, Hunan Normal University, Changsha 410081, P. R. China College of Material Chemistry and Chemical Engineering Hangzhou Normal University Hangzhou 310036 China Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China; Pancreatic Disease Research Center, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu 215006, China Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P. R. China; State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. China Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education); Fudan University; Shanghai PR China Institute of Orthopaedics Lanzhou General Hospital, Lanzhou Command of People's Liberation Army Lanzhou P.R. China Shanghai Key Laboratory of Green Chemistry and Chemical Process, School of Chemistry and Molecular Engineering, East China Normal University, 3663 N. Zhongshan Road, Shanghai 200062, P. R. China; State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, P. R. China 1Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Jiao Tong University School of Medicine Affiliated Sixth People’s Hospital, Shanghai, 200233, China. WuXi AppTec, International Discovery Service Unit & Research Service Division, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China Department of Articular Orthopaedics, The Third Affiliated Hospital of Soochow University, Changzhou, P.R. China Department of Pharmacy The First Affiliated Hospital of Nanchang University Nanchang China 1Liver Cancer Institute, Zhong Shan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, Chinese Ministry of Education and Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, PR China;; Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, PR China; State Key Laboratory for Chemo/Biosensing and Chemometrics; College of Chemistry and Chemical Engineering; and School of Physics and Electronics; Hunan University; Changsha 410082 Department of Burn and Plastic Surgery, the Affiliated Hospital of Zunyi Medical University, Zunyi Guizhou, 563003, P.R.China. Sanbo Brain Hospital, Capital Medical University, Beijing, China Department of Materials Science and Engineering; Nanjing University; Nanjing 210093; P. R. China School of Materials Science and Engineering and Center for Integrated Computational Materials Engineering, International Research Institute for Multidisciplinary Science, Beihang University, Beijing 100191, China Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming 650118, China Tetraphase Pharmaceuticals, Inc., Watertown, Massachusetts, USA Department of Vascular Surgery, Changhai Hospital, Endovascular Diagnosis and Treatment Center for Heart Valvular Diseases, and Endovascular Diagnosis and Treatment Center for Aortic Dissection, Navy Medical University, Shanghai, China School of Resources and Environmental Engineering, Jiangxi University of Science and Technology, Ganzhou 341000, China Shanghai Respiratory Research Institute, Department of Pulmonary Medicine, Zhongshan Hospital Fudan University Shanghai China First People’s Hospital of Chenzhou City (Emergency Department), Chenzhou, 423000 Hunan, China Developmental Endocrinology BranchNICHDNational Institutes of HealthBethesda Maryland 20892 USA School of Chemical Science and Engineering The State Key Laboratory of Pollution Control and Resource Reuse Shanghai Key Laboratory of Chemical Assessment and Sustainability Tongji University Shanghai 200092 China Liver Cancer Institute Zhongshan Hospital Fudan University Shanghai P. R. China Department of Cardiology, Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730000, China. *Corresponding author, E-mail: [email protected]. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China. Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China; State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China Department of Obstetrics, Shanghai First Maternity and Infant Hospital, Shanghai 200040, China. Fishery Institute of the Sichuan Academy of Agricultural Sciences, Chengdu, China 1Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, P.R. China. Key Laboratory for Agro‐Ecological Processes in Subtropical Regions, Institute of Subtropical Agriculture the Chinese Academy of Sciences Changsha China The fifth Department of Biological products, Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College, Kunming, People’s Republic of China West China School of Medicine, Sichuan University, Chengdu, China Department of Vascular Surgery, the First Affiliated Hospital of the Navy Medical University, Shanghai 200433, China. College of Natural Resources and Environment, Northwest A&F University, Yangling, Shaanxi Province 712100, P.R. China; Key Laboratory of Plant Nutrition and the Agri-environment in Northwest China, Ministry of Agriculture, No.3 Taicheng Road, Yangling, Shaanxi 712100, P.R. China Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China; West China School of Medicine, Sichuan University, Chengdu, China Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular Engineering East China Normal University 3663 N Zhongshan Road Shanghai 200062 China; State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Chinese Academy of Sciences Shanghai 200032 P. R. China Department of Ophthalmology, Eye Institute of PLA, Xijing Hospital, Fourth Military Medical University, Xi’an, Shaanxi, China College of Mechanical and Vehicle Engineering, Hunan University, Changsha 410082, China Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Department of Endocrinology Metabolism of Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233, China. Beijing Key Laboratory for Green Catalysis and Separation and Department of Environmental Chemical Engineering, Beijing University of Technology, Beijing 100124, China Liver Cancer Institute and Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion; Fudan University, Ministry of Education; Shanghai People's Republic of China; Institute of Biomedical Sciences; Fudan University; Shanghai People's Republic of China Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital Fudan University Shanghai People's Republic of China; Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education Shanghai People's Republic of China; Institute of Biomedical Sciences Fudan University Shanghai People's Republic of China Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated 6th People’s Hospital, Shanghai Diabetes Institute, Shanghai Clinical Center for Diabetes, Shanghai, China Department of Intensive Care Medicine, Xintian General Hospital, Xintian, Hunan, P.R. China. National Laboratory of Solid State Microstructures and Department of Materials Science and Engineering, Nanjing University, 22 Hankou Road, Nanjing, Jiangsu 210093, People’s Republic of China Department of Liver Surgery, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai 200032, P.R. China Chinese Academy of Sciences; University of Chinese Academy of Sciences Department of ICU, Zhujiang Hospital of Southern Medical University, Guangzhou, Guangdong, China Department of Orthopedics The Second Xiangya Hospital Central South University Changsha Hunan China; Department of Sports Medicine Research Center Central South University Changsha China Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China Imaging and Interventional Radiology, Sun Yat-sen University Cancer Center; State Key Laboratory of Oncology in South China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, PR China Department of Pharmacology, University of Illinois College of Medicine, Chicago Department of Physics, Virginia Commonwealth University, Richmond, Virginia 23284, United States Beijing Key Laboratory of Epilepsy Sanbo Brain Hospital Capital Medical University Beijing China; Department of Neurosurgery, Epilepsy Center Sanbo Brain Hospital Capital Medical University Beijing China State Key Laboratory of Reproductive Regulation and Breeding of Grassland Livestock, College of Life Sciences, Inner Mongolia University, Hohhot 010070, China State Key Laboratory of Robotics and Systems, Harbin Institute of Technology, West Da-zhi Street 92, Harbin, Heilongjiang 150001, People's Republic of China Institute of OrthopaedicsLanzhou General HospitalCPLALanzhou 730050People's Republic of China 1Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai, China.; 7Institute of Biomedical Sciences, Fudan University, Shanghai, China.; 8State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China. College of Polymer Science and Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan Unversity, Chengdu 610065, China, and Ningbo Institute of Material Technology and Engineering, Chinese Academy of Sciences, Ningbo Key Laboratory of Polymer Materials, Ningbo 315201, China Gaozhou Center for Disease Control and Prevention, Maoming, People’s Republic of China Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital Fudan University Shanghai China; Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education Shanghai China; Institutes of Biomedical Sciences Fudan University Shanghai China College of Natural Resources and Environment, Northwest A&F University, Yangling 712100, China; Key Laboratory of Low-Carbon Green Agriculture in Northwestern China, Ministry of Agriculture and Rural Affairs, Yangling 712100, China Department of Advanced Materials and Nanotechnology, College of Engineering, Peking University, Beijing 100871, China Department of Neurosurgery, Beijing Sanbo Hospital Capital Medical University Beijing China Department of Geriatrics, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China Department of Chemistry Hong Kong Baptist University Hong Kong China Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai China Department of Vascular Surgery, Changhai Hospital, Second Military Medical University, Shanghai, P.R. China National Laboratory of Solid State Microstructures & Department of Materials Science and Engineering & Jiangsu Key Laboratory of Artificial Functional Materials, Nanjing University, Nanjing 210093 China King Abdullah University of Science and Technology (KAUST), Physical Science and Engineering Division, COHMAS Laboratory, Thuwal 23955-6900, Saudi Arabia Max-Planck-Institut für Kohlenforschung, D-45470 Mülheim an der Ruhr, Germany Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University; State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, P. R. China; State Key Laboratory and Institute of Elemento-organic Chemistry, Nankai University, Tianjin 300071, P. R. China Department of Otorhinolaryngology Head and Neck Surgery, Eye, Ear, Nose and Throat Hospital of Fudan University, Shanghai 200031, China. Department of Liver Surgery and Transplantation Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education) Fudan University Shanghai China Department of Nutrition and Food Hygiene & Department of Health Education and Health Management the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational EnvironmentAir Force Medical University Xi'an China Department of Vascular Surgery Changhai Hospital Second Military Medical University Shanghai China Department of Liver Surgery and Transplantation,Liver Cancer Institute, Zhongshan Hospital,Shanghai,China; Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University),Ministry of Education,Shanghai,China; Institute of Biomedical Sciences,Fudan University,Shanghai,China; Shanghai Key Laboratory of Organ Transplantation,Zhongshan Hospital, Fudan University,Shanghai,China; State Key Laboratory of Genetic Engineering,Fudan University,Shanghai,China Department of Plastic Surgery and Burns, the Affiliated Hospital of Zunyi Medical University, Zunyi Guizhou, 563003, P. R. China. Department of Otolaryngology, Eye Ear Nose and Throat Hospital, Fudan University, Shanghai, China. Department of Liver Surgery and Transplantation of Zhongshan Hospital, Liver Cancer Institute of Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Laboratory of epigenetics of Institutes of Biomedical Sciences, Key Laboratory of Birth Defects of Children's Hospital Fudan University Shanghai China Liver Cancer Institute, Zhongshan Hospital, Fudan University, 180 Fenglin Rd., Xuhui District, Shanghai, 200032, China. [email protected]. Department of Molecular and Human Genetics, Baylor College of Medicine; Jan and Dan Duncan Neurological Research Institute at Texas Children’s Hospital School of Metallurgy and Chemistry Engineering, Jiangxi University of Science and Technology, Ganzhou 341000, China Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha 410011, Hunan, China Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, P.R. China Guangdong Provincial Key Lab for Green Chemical Product Technology, School of Chemistry and Chemical Engineering, South China University of Technology , Guangzhou, Guangdong 510640, People's Republic of China Department of Orthopedics Beijing Shijitan Hospital Affiliated to Capital Medical University, Peking University Ninth School of Clinical Medicine Beijing China Department of Thoracic Surgery West China Hospital Sichuan University Chengdu Sichuan 610041 P. R. China Department of Orthopedics (Spine Surgery) The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China; School of Pharmacy, and Department of Neurosurgery The Affiliated Hospital, Hangzhou Normal University Hangzhou Zhejiang China Department of Burn and Reconstruction, the First Affliated Hospital of Zhengzhou University, Zhengzhou, China Department of Bioengineering, University of Pittsburgh, Pittsburgh, PA 15213, USA Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education; Institutes of Biomedical Sciences, Fudan University State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Department of Radiology, Sun Yat-sen University Cancer Center, Guangzhou, Guangdong, China; South China Hospital, Medical School, Shenzhen University, Shenzhen, Guangdong, China Department of Physics Virginia Commonwealth University Richmond Virginia 23284 USA National Laboratory of Solid-State Microstructures, Collaborative Innovation Center of Advanced Microstructures, and School of Electronic Science and Engineering, Nanjing University, Nanjing, Jiangsu 210023, China Department of Otolaryngology, Eye Ear Nose & Throat Hospital, Fudan University, Shanghai, China. Center for Advancing Materials Performance from the Nanoscale; State Key Laboratory for Mechanical Behavior of Materials; Xi'an Jiaotong University; Xi'an; China Key Laboratory of the Three Gorges Reservoir Region's Eco-environments, Ministry of Education, Chongqing University, 174 Shazheng Road, Chongqing 400045, China Department of Occupational and Environmental Health, School of Public Health and Management Ningxia Medical University Yinchuan People's Republic of China; Key Laboratory of Environmental Factors and Chronic Disease Control, School of Public Health and Management Ningxia Medical University Yinchuan People's Republic of China Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School of Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, Chinese Ministry of Education, Shanghai, Peoples Republic of China National Laboratory of Solid State Microstructures and Department of Materials Science and Engineering, Nanjing University Nanjing Jiangsu 210093 China Department of Surgical Oncology, Zhejiang Taizhou Municipal Hospital, Taizhou, Zhejiang, China (mainland) Institute of Orthopaedics, Lanzhou General Hospital of PLA, Lanzhou 730050, China. The Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, The Chinese Ministry of Education, Shanghai, P.R. China Institute of Orthopaedics, Lanzhou General Hospital of PLA, Lanzhou 730050, China. [email protected] Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China Department of Otorhinolaryngology, Eye, Ear, Nose, and Throat Hospital Fudan University Shanghai China Department of Endocrinology and Metabolism, Shanghai Clinical Center for Diabetes, Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China Department of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China; Department of General Surgery, Nanjing First Hospital, Nanjing Medical University, Nanjing, Jiangsu, China Department of Thoracic Surgery , Center of Thoracic Mini-invasive Surgery, , Beijing , China; Peking University People’s Hospital , Center of Thoracic Mini-invasive Surgery, , Beijing , China Department of Vascular Surgery Changhai Hospital, Navy Medical University Shanghai China College of Food Science, Southwest University, Chongqing, PR China; Modern “Chuan cai Yu wei” Food Industry Innovation Research Institute, Chongqing, China Department of Thoracic Surgery, West China Hospital, Sichuan University , Chengdu, China; Western China Collaborative Innovation Center for Early Diagnosis and Multidisciplinary Therapy of Lung Cancer, Sichuan University , Chengdu, China; West China School of Medicine, Sichuan University , Chengdu, China; Institute of Thoracic Oncology, West China Hospital, Sichuan University , Chengdu, China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, No.1 West Beichen Road, Chaoyang District, Beijing 100101, China Department of Hematology, Henan Tumor Hospital, Henan Institute of Hematology, Zhengzhou 450003, Henan Province, China. Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China;; Shanghai Respiratory Research Institute, Shanghai, China; and Department of Radiology Third Military Medical University Qiqihar Heilongjiang P.R. China Department of Neurosurgery The Affiliated Hospital of Southwest Medical University Luzhou China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital College of Medicine, Zhejiang University, Hangzhou 310003, China. National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Key Laboratory of Agro‐ecological Processes in Subtropical Region, Scientific Observing and Experimental Station of Animal Nutrition and Feed Science in South‐Central, Ministry of Agriculture, Hunan Provincial Engineering Research Center for Healthy Breeding of Livestock and Poultry, Institute of Subtropical Agriculture Chinese Academy of Sciences Changsha China Key Lab of Tea Chemical Engineering, Ministry of Agriculture, Tea Research Institute, Chinese Academy of Agriculture Science, Hangzhou 310008, China. [email protected] Department of Pathology Harbin Medical University Harbin China Department of Radiology, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Sun Yat-Sen University Cancer Center, Guangzhou, People’s Republic of China Department of Otolaryngology, Eye, Ear, Nose, and Throat Hospital, Fudan University, Shanghai, China Department of Hematology Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital Zhengzhou Henan China State Key Laboratory of Microbial Resources Institute of Microbiology, Chinese Academy of Sciences Beijing China Department of Liver Surgery and Transplantation Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education Liver Cancer Institute and Zhongshan Hospital, Fudan University Shanghai 200032 P. R. China Department of Liver Surgery & Transplantation Liver Cancer Institute Zhongshan Hospital Fudan University Shanghai China; Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education Shanghai China; Institutes of Biomedical Sciences Fudan University Shanghai China Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, 180 Fenglin Road, Shanghai 200032, P. R. China The Department of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou, P.R. China Department of Thoracic Surgery, West China Hospital Sichuan University Chengdu China; West China School of Medicine Sichuan University Chengdu China Department of Liver Surgery & Transplantation Liver Cancer Institute Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education Zhongshan Hospital, Fudan University Shanghai P. R. China; Institutes of Biomedical Sciences Fudan University Shanghai P. R. China From the Developmental Endocrinology Branch, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Md Department of Chemistry and Biomolecular Science, and NanoBio Laboratory (NABLAB), Clarkson University, Potsdam, New York 13699-5810 Department of Pediatric Laboratory, Wuxi Children's Hospital Affiliated to Nanjing Medical University, Wuxi, Jiangsu 214023, China School of Mechatronics Engineering Harbin Institute of Technology West Da‐zhi Street 92 Harbin 150001 P. R. China Liver Cancer Institute, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Zhongshan Hospital, Fudan University, Shanghai, China; Shanghai Key Laboratory of Organ Transplantation, Shanghai, China Institute of Quality Standard and Testing Technology for Agri-products, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100081, P.R. China; Key Laboratory of Agro-food Safety and Quality, Ministry of Agricultures, Beijing 100081, P.R. China Department of Medical Oncology, Fuyang People's Hospital, Fuyang, Anhui 236000, P.R. China College of Life Sciences, Hunan Normal University, Changsha, P.R. China Dept. of VIP Dental Service, Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, China. National Engineering Research Center for Breeding Swine Industry, Guangdong Provincial Key Lab of Agro-Animal Genomics and Molecular Breeding, College of Animal Science, South China Agricultural University, Guangzhou 510642, China Beijing Key Laboratory of Epilepsy, Sanbo Brain Hospital, Capital Medical University;; Department of Neurosurgery, Epilepsy Center, Sanbo Brain Hospital, Capital Medical University; and Department of Cardiac Surgery, Heart Center, Chaoyang Hospital, Capital Medical University Department of Pediatrics, The First People’s Hospital of Yongkang, Yongkang, China The Fifth Department of Biological Products, Institute of Medical Biology, Chinese Academy of Medical Science and Peking Union Medical College, Kunming, Yunnan Province, People's Republic of China School of Materials Science and Engineering; and Center for Integrated Computational Materials Engineering; International Research Institute for Multidisciplinary Science; Beihang University; Beijing 100191 Department of General Surgery Huashan Hospital Fudan University Shanghai China Shanghai Key Laboratory of Green Chemistry and Chemical Processes East China Normal University 3663N Zhongshan Road Shanghai 200062 China; State Key Laboratory of Organometallic Chemistry Shanghai Institute of Organic Chemistry Shanghai 200032 China Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education; Shanghai P.R. China; Shanghai Key Laboratory of Organ Transplantation; Shanghai P. R. China Tribology Research Institute, School of Mechanical Engineering, Southwest Jiaotong University, Chengdu 610031, P. R. China Department of Urology, University of Texas Southwestern Medical Center, Dallas, TX 75390; Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai 200032, China. Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Fudan University, Shanghai 200032, P. R. China Department of Chemistry Hong Kong Baptist University Kowloon Hong Kong China Center for Alloy Innovation and Design, State Key Laboratory for Mechanical Behavior of Materials, Xi’an Jiaotong University, Xi’an 710049, China Institute of Orthopaedics (L-G.M., X.L., X-N.M., B-F.G., P.Z., P.S., J.Z., K-M.C.), Lanzhou Command of PLA, Lanzhou, People's Republic of China Authors' Affiliations: 1Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, 2Department of Pathology, Shanghai Medical School, 3Institute of Biomedical Sciences, Fudan University; and 4State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China; Authors' Affiliations: 1Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, 2Department of Pathology, Shanghai Medical School, 3Institute of Biomedical Sciences, Fudan University; and 4State Key Laboratory of Oncogenes and Related Genes, Shanghai Cancer Institute, Renji Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, PR China State Key Laboratory of Green Chemical Engineering and Industrial Catalysis, Shanghai Research Institute of Petrochemical Technology, SINOPEC Corp., Shanghai 201208, China Zhongshan Hospital, Fudan University Shanghai China; Shanghai Xuhui Central Hospital/Zhongshan‐Xuhui Hospital, Fudan University Shanghai China Key Laboratory of Eco-environments in the Three Gorges Reservoir Region, Ministry of Education, Faculty of Urban Construction and Environmental Engineering, National Centre for International Research of Low-Carbon and Green Buildings, Chongqing University, Chongqing 400044, China Department of Liver Surgery & Transplantation Liver Cancer Institute Zhongshan Hospital Fudan University Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education Shanghai China Department of Liver Surgery Zhongshan Hospital Fudan University China Department of Cardiology Gansu Provincial Hospital of TCM Lanzhou Gansu China Department of Hematology, The Affiliated Cancer Hospital of Zhengzhou University, Zhengzhou, Henan, China. Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062 China Department of Immunology, Tianjin Medical University Cancer Institute and Hospital , Hexi District, Tianjin, China; Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer , Hexi District, Tianjin, China; Key Laboratory of Cancer Prevention and Therapy , Tianjin, China; Tianjin's Clinical Research Center for Cancer , Tianjin, China; Key Laboratory of Cancer Immunology and Biotherapy , Tianjin, China The First Affiliated Hospital, Jinan University, Guangzhou, Guangdong 510632, China Division of Infectious Diseases, Center for Disease Control and Prevention, Weifang City, Shandong Province, China. Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China. Authors' Affiliation: Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, P.R. China School of Chemical Engineering, Nanjing University of Science and Technology, 210094 Nanjing, P. R. China Salivary Gland Disease Center and Beijing Key Laboratory of Tooth Regeneration and Function Reconstruction, Beijing Laboratory of Oral Health and Beijing Stomatological Hospital, Capital Medical University, Beijing 100050, P. R. China; Department of VIP Dental Service, School of Stomatology, Capital Medical University, Beijing 100050, P. R. China; Laboratory for Oral and General Health Integration and Translation, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, P. R. China Department of Ophthalmology, Eye Institute of Chinese PLA, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China Department of Liver Surgery Liver Cancer Institute Zhongshan Hospital,Fudan University,Shanghai,China Nanjing University 1 Group of Computational Condensed Matter Physics, National Laboratory of Solid State Microstructures, , Nanjing 210093, China; Nanjing University 3 Department of Material Science and Engineering, , Nanjing 210093, China Centre for Immunology & Cancer Research, University of Queensland, Princess Alexandra Hospital, Brisbane, Queensland 4102, Australia Department of Otolaryngology, Eye Ear Nose & Throat Hospital, Fudan University, Shanghai, PR China; Shanghai Key Clinical Disciplines of Otorhinolaryngology, Shanghai, PR China Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing 100070, P.R. China 1Liver Cancer Institute, Zhong Shan Hospital and Shanghai Medical School, State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032 Department of Endocrinology and Metabolism, Shanghai Diabetes Institute, Sixth People's Hospital, Jiaotong University, Shanghai 200233, China. Department of Urology, The Fourth Affiliated Hospital of Nantong Medical College, Yancheng People’s Hospital, Yancheng 224001, China Department of Chemistry and Biomolecular Science and Department of Physics, Clarkson University, Potsdam, New York 13676, United States National Laboratory of Solid‐State Microstructures School of Electronic Science and Engineering Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjing 210093 China College of Material Chemistry and Chemical Engineering Hangzhou Normal University Hangzhou 311121 P. R. China State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, 38 Zheda Road, Hangzhou, 310027, China Key Laboratory of Three Gorges Reservoir Region's Eco‐Environment Ministry of Education Chongqing University Chongqing People's Republic of China; National Centre for International Research of Low‐Carbon and Green Buildings Chongqing University Chongqing People's Republic of China State Laboratory of High Performance Ceramic and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China Shanghai Key Laboratory of Green Chemistry and Chemical Processes; School of Chemistry and Molecular Engineering; East China Normal University; Shanghai 200062; China Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, People's Republic of China; Institutes of Biomedical Sciences, Fudan University, Shanghai, People's Republic of China Center For Earth System Science, Tsinghua University, Beijing 100084, China Department of Radiology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China Department of Live Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China Department of Liver Surgery and Transplantation,Liver Cancer Institute Zhongshan Hospital Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education Key Laboratory of Medical Epigenetics and Metabolism Institutes of Biomedical Sciences Fudan University Shanghai China Department of Cardiovascular Medicine, Shanghai East Hospital, School of Medicine Tongji University Shanghai China The First Affiliated Hospital of Guangzhou University of Chinese Medicine Department of Occupational and Environmental Health 1Department of Liver Surgery and Transplantation, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education), Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China. Department of Cardiology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China; The Key Lab of Cardiovascular Disease, Science and Technology of Wenzhou, Wenzhou, China The Fifth Department of Biological Products, Institute of Medical Biology, Chinese Academy of Medical Science, Peking Union Medical College, Kunming, Yunnan Province, People's Republic of China Department of Geriatrics, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Anhui, 230001, People’s Republic of China Organ Transplant Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, Guangdong, China (mainland) Department of Pathophysiology, Third Military Medical University, Chongqing, People's Republic of China; Institute of Immunology, People's Liberation Army (PLA), Third Military Medical University, Chongqing, People's Republic of China National Laboratory of Solid State Microstructures Jiangsu Key Laboratory of Artificial Functional Materials College of Engineering and Applied Sciences Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjing 210023 P. R. China College of Material, Chemistry and Chemical Engineering Hangzhou Normal University Hangzhou China Department of Pathology, Harbin Medical University, Harbin 150081, China Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education Department of Liver Surgery Liver Cancer Institute Zhongshan Hospital Fudan University Shanghai China; Institutes of Biomedical Sciences Fudan University Shanghai China Departments of Neurosurgery and; Beijing Key Laboratory of Epilepsy, Beijing; and; Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing, China Authors' Affiliations: 1Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, and 2Institute of Biomedical Sciences, Fudan University, Shanghai, China; Authors' Affiliations: 1Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, and 2Institute of Biomedical Sciences, Fudan University, Shanghai, China Department of General Surgery, The First Affiliated Hospital of Soochow University, Suzhou 215006, China; Pancreatic Disease Research Centre, The First Affiliated Hospital of Soochow University, Suzhou 215006, China Institutes of Biomedical Sciences, Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Key Laboratory of Medical Epigenetics and Metabolism, Fudan University, Shanghai, China Department of Biomedical Engineering, University of California-Davis, California, USA. Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China Laboratory of Neural Signal Transduction, Institute of Neuroscience, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, 320 Yueyang Road, Shanghai, 200031, China. Department of Endocrinology and Metabolism , Shanghai, , China; Shanghai Jiao Tong University Affiliated Sixth People's Hospital , Shanghai, , China; Shanghai Clinical Center for Diabetes , Shanghai, , China; Shanghai Key Clinical Center for Metabolic Disease , Shanghai, , China; Shanghai Diabetes Institute , Shanghai, , China; Shanghai Key Laboratory of Diabetes Mellitus , Shanghai, , China Ningbo Municipal Center for Disease Control and Prevention, Ningbo 315010, China. Soochow University School of Electronics and Information Engineering, , Suzhou, China Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, 3663 North Zhongshan Road, Shanghai 200062, China Tumor Hospital Affiliated to Xinjiang Medical University, Xinjiang Uygur Autonomous Region, Urumqi, P.R. China. State Key Laboratory of Pathogenesis, Prevention, Treatment of Central Asian High Incidence Diseases, Xinjiang Uygur Autonomous Region, Urumqi, P.R. China. Department of Pathology, the Affiliated Hospital of Southwest Medical University, Luzhou, P.R. China. Department of Liver Surgery & Transplantation Liver Cancer Institute Zhongshan Hospital Fudan University Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education Shanghai P. R. China Department of Liver Surgery Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education Liver Cancer Institute, Zhongshan Hospital, Fudan University Shanghai China School of Public Health, Weifang Medical College, Weifang 261053. Department of Neurosurgery Center The National Key Clinical Specialty The Engineering Technology Research Center of Education Ministry of China on Diagnosis and Treatment of Cerebrovascular Disease Guangdong Provincial Key Laboratory on Brain Function Repair and Regeneration The Neurosurgery Institute of Guangdong Province Zhujiang Hospital Southern Medical University Guangzhou China College of Chemistry; Chongqing Normal University; Chongqing; P. R. China Center for Biophysical Modeling and Simulation, Department of Chemistry, University of Utah, Salt Lake City, Utah 84112-0850 Institute of Quality Standard and Testing Technology for Agro-Products, Chinese Academy of Agricultural Sciences, Beijing 100081, China Department of Radiology Collaborative Innovation Center for Cancer Medicine, State Key Laboratory of Oncology in South China, Sun Yat‐Sen University Cancer Center Guangzhou 510060 China Department of Neurosurgery, Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Epilepsy Research, Sanbo Brain Hospital, Capital Medical University, Beijing, China; Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education),Fudan University,Shanghai,P.R. China; Institute of Biomedical Sciences,Fudan University,Shanghai,P.R. China Department of Chemistry and Biology, Yulin Normal University, Yulin 537000, China Department of Neurosurgery, San Bo Brain Hospital, Capital Medical University, Haidian, Beijng, P. R. China Authors' Affiliations: 1Department of Chemistry, 2Liver Cancer Institute, Zhongshan Hospital, 3Institutes of Biomedical Sciences, Fudan University; 4Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai; and 5Department of Surgery, Fujian Provincial Tumor Hospital, Teaching Hospital of Fujian Medical University, Fuzhou, China; Authors' Affiliations: 1Department of Chemistry, 2Liver Cancer Institute, Zhongshan Hospital, 3Institutes of Biomedical Sciences, Fudan University; 4Med-X Research Institute and School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai; and 5Department of Surgery, Fujian Provincial Tumor Hospital, Teaching Hospital of Fujian Medical University, Fuzhou, China Department of Pediatrics, The First People’s Hospital of Yongkang, Jinhua, China Key Laboratory of Systems Bioengineering, Ministry of Education and Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, Tianjin University, Tianjin, P.R. China. Department of Neurosurgery, SanBo Brain Hospital Capital Medical University Beijing China Department of Pharmacy, The First Affiliated Hospital of Nanchang University, Nanchang, Jiangxi, People’s Republic of China Liver Cancer Institute, Zhongshan Hospital; State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, People's Republic of China Department of Thoracic Surgery Peking University People's Hospital Beijing China Peking University 2 Department of Materials Science and Engineering, College of Engineering, , Beijing 100871, China Department of Oral and Maxillofacial Surgery, School of Stomatology, Stomatological Hospital, Anhui Medical University, Hefei, China West China School of Medicine Sichuan University Chengdu China; Department of Thoracic Surgery West China Hospital Sichuan University Chengdu China Nanjing University Department of Liver Surgery and Transplantation and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education) Liver Cancer Institute Zhongshan Hospital Fudan University Shanghai 200000 China Flatiron Institute, Simons Foundation, New York, New York, USA. Pennington Biomedical Research Center, Baton Rouge, LA; Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai, China Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University and Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Shanghai Jiao Tong University, Sixth People's Hospital, Shanghai Diabetes Institute, Shanghai, China. State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, 354 Fenglin Road, Shanghai 200032, China Department of Cardiac Surgery, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China Department of Endocrinology and Metabolism Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai Key Clinical Center for Metabolic Disease Shanghai China Department of Geotechnical Engineering, Tongji University, Shanghai 200092, China; Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education, Tongji University, Shanghai 200092, China Department of Pharmacological and Pharmaceutical Sciences, University of Houston College of Pharmacy, Houston, Texas, USA Developmental Endocrinology Branch (J.Z., C.B.) National Institute of Child Health and Human Development National Institutes of Health Bethesda, Maryland 20892 Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratorsy of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China; Key Laboratory of Medical Epigenetics and Metabolism, Institute of Biomedical Sciences, Fudan University, Shanghai, China; Shanghai Key Laboratory of Organ Transplantation, Shanghai, China State Key Laboratory of Lake Science and Environment, Nanjing Institute of Geography and Limnology, Chinese Academy of Sciences, 73 East Beijing Road, Nanjing 210008, P. R. China Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou 510060, China Department of Cardio-Thoracic Surgery, Shanghai Tenth People’s Hospital Affiliated to Tongji University , Shanghai 200072 , China National Center for Tea Improvement, Tea Research Institute, Chinese Academy of Agricultural Sciences, Hangzhou 310008, China. [email protected] Ningbo Municipal Center for Disease Control and Prevention, Key Laboratory of Health Risk Appraisal for Trace Toxic Chemicals of Zhejiang Province, Ningbo 315010, China. State Key Laboratory of Chemical Engineering, College of Biological and Chemical Engineering, Zhejiang University, 38 Zheda Road, Hangzhou 310027, China Department of Otolaryngology-Head and Neck Surgery, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, PR China;; Shanghai Key Clinical Disciplines of Otorhinolaryngology, Eye, Ear, Nose and Throat Hospital, Fudan University, Shanghai, PR China Department of Chemistry Hong Kong Baptist University Kowloon Hong Kong China; Department of Chemistry Southern University of Science and Technology Shenzhen Guangdong 518055 China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, People's Republic of China Department of Medical Imaging Cancer Center, Sun Yat‐Sen University Guangzhou Guangdong China Department of Materials Science and Engineering, University of California, Berkeley, California 94720, United States Physical Chemistry University of Konstanz Universitätsstrasse 10 78457 Konstanz Germany Department of Breast Surgery, Jiangsu Taizhou People’s Hospital, Taizhou, China Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Fudan University, Shanghai 200032, China.; Key Laboratory of Medical Epigenetics and Metabolism, Institutes of Biomedical Sciences, Fudan University, Shanghai 200032, China. Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Clinical Center for Diabetes; Shanghai Key Clinical Center for Metabolic Disease; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China; Department of Endocrinology and Metabolism, Jinshan Branch of Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai 201500, China. Physics Department; Virginia Commonwealth University; Richmond; USA Department of Neurosurgery, Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Epilepsy Research Sanbo Brain Hospital, Capital Medical University Beijing 100093 China State Key Laboratory of Heavy Oil Processing, China University of Petroleum, Beijing 102249, China Low Carbon & Ecological Research Center, Guangdong Provincial Academy of Environment Science, Guangzhou 510045, China. [email protected] South China University of Technology School of Chemistry and Chemical Engineering, , Guangdong Provincial Key Lab for Green Chemical Product Technology, Guangzhou 510640, China Department of Chemistry and Biomolecular Science and NanoBio Laboratory (NABLAB), Clarkson University, Potsdam, New York 13699-5810 BioMicroSystems Laboratory, School of Electronic and Computing Systems, University of Cincinnati , Cincinnati, Ohio 45221, USA 1Department of Endocrinology and Metabolism, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University, Shanghai Clinical Medical Center of Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Institute of Diabetes, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China Department of Liver Surgery & Transplantation, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis & Cancer Invasion (Fudan University), Ministry of Education, Shanghai 200032, PR China; State Key Laboratory of Genetic Engineering, Fudan University, Shanghai 200032, PR China; Institute of Biomedical Sciences, Fudan University, Shanghai 200032, PR China Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, 3663N Zhongshan Road, Shanghai 200062, China; State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, P. R. China Department of Orthopedics (Spine Surgery) The First Affiliated Hospital of Wenzhou Medical University Wenzhou Zhejiang China Peking University 1 Department of Materials Science and Engineering, College of Engineering, , Beijing 100871, China Department of Physics Virginia Commonwealth University Richmond VA 23284 USA Authors' Affiliations: 1Liver Cancer Institute, Zhongshan Hospital, Fudan University; 2Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education; and 3Institute of Biomedical Sciences, Fudan University, Shanghai, China; Authors' Affiliations: 1Liver Cancer Institute, Zhongshan Hospital, Fudan University; 2Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education; and 3Institute of Biomedical Sciences, Fudan University, Shanghai, China; Authors' Affiliations: 1Liver Cancer Institute, Zhongshan Hospital, Fudan University; 2Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education; and 3Institute of Biomedical Sciences, Fudan University, Shanghai, China School of Chemical Engineering; Nanjing University of Science and Technology; 210094 Nanjing; P. R. China School of Chemistry and Chemical Engineering; Guangdong Provincial Key Lab for Green Chemical Product Technology; South China University of Technology; Guangzhou; P. R. China Department of Liver Surgery and Transplantation Liver Cancer Institute Zhongshan Hospital Fudan University Shanghai China; Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education Shanghai China; Key Laboratory of Medical Epigenetics and Metabolism Institutes of Biomedical Sciences Fudan University Shanghai China †Center for Wound Healing and Tissue Regeneration, College of Dentistry, University of Illinois, Chicago, IL 60612 Department of Pathology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory for Carcinogenesis and Cancer Invasion, Chinese Ministry of Education, Shanghai, China Shanghai Key Laboratory of Green Chemistry and Chemical Process, Department of Chemistry, East China Normal University, Shanghai 200062, P. R. China; State Key Laboratory of Elemento-organic Chemistry, Nankai University, Tianjin 300071, P. R. China Bio-X Center, Shanghai Jiao Tong University, Shanghai, China, Institute for Nutritional Sciences, Shanghai Institutes of Biological Sciences, Chinese Academy of Sciences, Shanghai, China, Institutes of Biomedical Sciences, Fudan University, Shanghai, China, Shanghai Institute of Mental Health, Shanghai, China, School of Life Science, Ningxia University, Yinchuan, China, and Key Laboratory of Developmental Genetics and Neuropsychiatric Diseases (Shanghai Jiao Tong University), Ministry of Education,... State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China State Key Laboratory of Robotics and System Harbin Institute of Technology Harbin 150001 P. R. China Department of Vascular Surgery, The First Affiliated Hospital of the Navy Medical University (Changhai Hospital), Shanghai, China; Shanghai Key Laboratory of Vascular Lesions Regulation and Remodeling, Shanghai, China 1Department of Urology, University of Texas Southwestern Medical Center, Dallas, Texas and Department of Pulmonary Medicine Research Institute of Respiratory Disease, Zhongshan Hospital, Fudan University Shanghai China Authors' Affiliations: 1Liver Cancer Institute, Zhong Shan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis & Cancer Invasion, Chinese Ministry of Education; 2National Laboratory for Oncogenes and Related Genes, WHO Collaborating Center for Research on Cancer, Shanghai Cancer Institute, Shanghai Jiao Tong University School of Medicine; 3Experimental Research Center, Zhongshan Hospital, Fudan University; 4Institute of Biomedical Sciences, Fudan University, Shanghai, People's Republic of China Department of Clinical Sciences and Administration, University of Houston College of Pharmacy, Houston, Texas, USA Shanghai Research Institute of Petrochemical Technology, SINOPEC, Shanghai 201208, P. R. China. Department of Liver Surgery, Liver Cancer Institute, Zhongshan hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai, P. R. China Internal Medicine Center Laboratory, Dongtai People Hospital, Dongtai, Jiangsu Province, China Department of Thoracic Surgery, West China Hospital, Sichuan University, Chengdu, China.; West China School of Medicine, Sichuan University, Chengdu, China. Department of Laboratory Medicine The First Affiliated Hospital of Xi'an Medical University Xi'an Shaanxi China Reproductive Medicine Center The First Affiliated Hospital of SooChow University SuZhou 215006 China 1Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University.; 2Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of Education, Shanghai, China.; 3Shanghai Key Laboratory of Organ Transplantation, Zhongshan Hospital, Fudan University, Shanghai, China. Henan Cancer Hospital The Affiliated Cancer Hospital of Zhengzhou University Zhengzhou China Department of Liver Surgery and Liver Transplantation Liver Cancer Institute Zhongshan Hospital and Shanghai Medical School Fudan University Key Laboratory for Carcinogenesis and Cancer Invasion The Chinese Ministry of Education Shanghai China Department of Otolaryngology, Shanghai Key Clinical Disciplines of otorhinolaryngology, Eye Ear Nose & Throat Hospital Fudan University Shanghai People's Republic of China 1Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Fudan University, Shanghai, China.; 3Institute of Biomedical Sciences, Fudan University, Shanghai, China.; 4State Key Laboratory of Genetic Engineering and Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China. Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, and Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, 180 Fenglin Road, Shanghai 200032, China; Research Unit of Bench and Clinic Research for Liver Cancer Recurrence and Metastasis, Chinese Academy of Medical Sciences (No. 2019RU050), Shanghai 200032, China Intensive Care Unit, Daping Hospital, Third Military Medical University, Chongqing 400042, China Department of Gynecological Oncology, Hunan Provincial Tumor Hospital The Affiliated Tumor Hospital of Xiangya Medical School of Central South University Changsha China College of Chemistry; Chongqing Normal University; Chongqing; P. R. China; Department of Physics and CICECO-Aveiro Institute of Materials College of Chemistry and Material, Yulin Normal University, Yulin 537000, P.R. China; College of Chemistry and Chemical Engineering, Jishou University, Jishou, 416000, P.R. China Department of Occupational and Environmental Health, School of Public Health and Management Ningxia Medical University Yinchuan Ningxia People's Republic of China; Key Laboratory of Environmental Factors and Chronic Disease Control, School of Public Health and Management Ningxia Medical University Yinchuan Ningxia People's Republic of China Department of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of Education, Shanghai, China; State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China; Shanghai Key Laboratory of Organ Transplantation, Zhongshan Hospital, Fudan University, Shanghai, China; Institute of Biomedical Sciences, Fudan University, Shanghai, China 2Developmental Endocrinology Branch, National Institute of Child and Development, and Reproductive Medicine Center, The First Affiliated Hospital of Soochow University, Suzhou, China; State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, 100101, Beijing, PR China Institute for Hepatology, National Clinical Research Center for Infectious Disease, Shenzhen Third People’s Hospital, The Second Affiliated Hospital, School of Medicine, Southern University of Science and Technology, Shenzhen, Guangdong Province, China Key Laboratory of Systems Bioengineering, Ministry of Education and Department of Pharmaceutical Engineering, School of Chemical Engineering and Technology, P.O. Box 6888, Tianjin University, Tianjin 300072, People's Republic of China Department of Liver Surgery; Liver Cancer Institute; Zhongshan Hospital, Fudan University; Shanghai, People's Republic of China; Key Laboratory for Carcinogenesis and Cancer Invasion; The Chinese Ministry of Education; Shanghai People's Republic of China Department of Burn and Plastic Surgery, Affiliated Hospital of Zunyi Medical University Department of Radiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangzhou 510060, Guangdong, P. R. China. School of Nursing, Fujian University of Traditional Chinese Medicine, Fuzhou, 350122, Fujian, China Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital; Shanghai Clinical Center for Diabetes; Shanghai Diabetes Institute; Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China. Department of Materials Science and Engineering, College of Materials, Xiamen University, Xiamen 361005, China; Department of Cardiovascular Medicine, Shanghai East Hospital, Tongji University School of Medicine, Shanghai, China School of Chemistry and Chemical Engineering, Guangdong Provincial Key Lab for Green Chemical Product Technology, South China University of Technology, Guangzhou, 510640, P. R. China National Laboratory of Solid-State Microstructures and School of Electronic Science and Engineering, Nanjing University, Nanjing 210093, China Authors' Affiliations: 1Liver Cancer Institute and 2Biomedical Research Center, Zhongshan Hospital; 3Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, and 4Institute of Biomedical Sciences, Fudan University, Shanghai, PR China; Authors' Affiliations: 1Liver Cancer Institute and 2Biomedical Research Center, Zhongshan Hospital; 3Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, and 4Institute of Biomedical Sciences, Fudan University, Shanghai, PR China; Authors' Affiliations: 1Liver Cancer Institute and 2Biomedical Research Center, Zhongshan Hospital; 3Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, and 4Institute of Biomedical Sciences, Fudan University, Shanghai, PR China Beijing Key Laboratory for Green Catalysis and Separation and Department of Environmental Chemical Engineering Beijing University of Technology Beijing 100124 P. R. China Institute of Medical Biology, Chinese Academy of Medical Sciences & Peking Union Medical College, Kunming, Yunnan, China; Yunnan Key Laboratory of Vaccine Research and Development on Severe Infectious Diseases, Kunming, Yunnan, China Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha; Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University; Engineering Research Center of Applied Technology of Pharmacogenomics, Ministry of Education; National Clinical Research Center for Geriatric Disorders, Changsha Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People’s Hospital, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Diabetes Institute, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai, China Department of General Practice, Affiliated Hospital of Chengde Medical College, Chengde, China Department of Liver Surgery and Transplantation, Liver Cancer Institute and State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China; Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Ministry of Education, Shanghai, China; Institute of Biomedical Sciences, Fudan University, Shanghai, China; Shanghai Key Laboratory of Organ Transplantation, Zhongshan Hospital, Fudan University, Shanghai, China Tumor Hospital Affiliated to Xinjiang Medical University Xinjiang Uygur Autonomous Region Urumqi P.R. China; State Key Laboratory of Pathogenesis, Prevention, Treatment of Central Asian High Incidence Diseases Xinjiang Uygur Autonomous Region Urumqi P.R. China Liver Surgery Department, Liver Cancer Institute, Zhongshan Hospital, Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of Education, Fudan University, Shanghai, China; Institute of Biomedical Sciences, Fudan University, Shanghai, China Sinopec Shanghai Research Institute of Petrochemical Technology, 1658 Pudong North Road, Shanghai 201208, P.R. China Discovery Technology China, Novo Nordisk Research Centre Novo Nordisk A/S Beijing China Department of Pharmacology, School of Pharmacy Hebei Medical University, Shijiazhuang, People's Republic of China. Department of Liver Surgery and Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, and Research Unit of Bench and Clinic Research for Liver Cancer Recurrence and Metastasis, Chinese Academy of Medical Sciences , Shanghai , China; Shanghai Key Laboratory of Organ Transplantation , Shanghai , China; Department of Radiology, Zhongshan Hospital, Fudan University , Shanghai , China Key Laboratory of Zoonosis Research, Ministry of Education, College of Animal Sciences, Jilin University, Changchun 130062, China Department of Pulmonary Medicine Zhongshan Hospital, Fudan University and Shanghai Respiratory Research Institute Shanghai P.R. China Department of Medical Imaging Sun Yat‐sen University Cancer Center State Key Laboratory of Oncology in South China Collaborative Innovation Center for Cancer Medicine Guangzhou China Liver Cancer Institute and Zhongshan Hospital, Fudan University Shanghai 200032, China ; Cancer Center, Institutes of Biomedical Sciences, Fudan University Shanghai 200031, China. Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, People's Republic of China Department of Biology and Center for Biological Clocks Research, Texas A&M University, College Station, Texas, USA. Department of Radiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangzhou, Guangdong, China Department of Endocrinology and Metabolism, Shanghai Jiao Tong University Affiliated Sixth People's Hospital, Shanghai Clinical Center for Diabetes, Shanghai Key Clinical Center for Metabolic Disease, Shanghai Key Laboratory of Diabetes Mellitus, Shanghai 200233, China State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, 38 Zheda Road, Hangzhou 310027, China; Institute of Zhejiang University-Quzhou, 78 Jiuhua Boulevard North, Quzhou 324000, China School of Materials Science and Engineering, Beihang University, Beijing 100191, China; Center for Integrated Computational Materials Engineering, International Research Institute for Multidisciplinary Science, Beihang University, Beijing 100191, China School of Chemistry and Chemical Engineering, Guangdong Provincial Key Lab for Green Chemical Product Technology, South China University of Technology, Guangzhou, Guangdong, 510640, People’s Republic of China Department of Cardiology, Beijing Key Laboratory of Hypertension, Beijing Chaoyang Hospital, Capital Medical University, China School of Materials Science and Engineering Ocean University of China Qingdao 266100 China 1Liver Cancer Institute, Zhong Shan Hospital and Ningbo Liver Disease Hospital, Ningbo 315010, Zhejiang, China. Shanghai Key Laboratory of Green Chemistry and Chemical Processes; School of Chemistry and Molecular Engineering; East China Normal University; 3663N; Shanghai 200062 Key Lab of Smart Prevention and Mitigation of Civil Engineering Disasters of the Ministry of Industry and Information Technology, and Key Lab of Structures Dynamic Behavior and Control of the Ministry of Education, Harbin Institute of Technology , Harbin 150090 , China Shanghai Key Laboratory of Green Chemistry and Chemical Processes, Department of Chemistry, East China Normal University, Shanghai 200062, P. R. China, and College of Chemistry, Sichuan University, Chengdu, Sichuan 610064, P. R. China Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Labolatory of Carcinogenesis and Cancer Invasion, Fudan University, Ministry of Education, Shanghai, China; State Key Laboratory of Genetic Engineering, Fudan University, Shanghai, China Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China; Institutes of Biomedical Sciences, Fudan University, Shanghai, People's Republic of China College of Resource and Environment, Huazhong Agricultural University, Wuhan 430070, China. State Key Laboratory of Microbial Resources Institute of Microbiology, Chinese Academy of Sciences Beijing 100101 China Beijing Key Laboratory for Green Catalysis and Separation and Department of Chemistry and Chemical Engineering Beijing University of Technology Beijing 100124 P. R. China Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China; Hunan Key Laboratory of Tumor Models and Individualized Medicine, The Second Xiangya Hospital, Central South University, Changsha, Hunan, China Department of Pathophysiology Third Military Medical University Chongqing China School of Materials Science and Engineering, Beihang University, Beijing 100191, China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing, China. Department of Vascular Surgery, Changhai Hospital, Second Military Medical University, Shanghai, China Botanical Garden Institute, Henan Institute of Science and Technology, Xinxiang 453003, China. [email protected] Department of Orthopedics, The First Medical Centre, Chinese PLA General Hospital, Beijing Key Lab of Regenerative Medicine in Orthopedics, Key Laboratory of Musculoskeletal Trauma & War Injuries PLA, No. 28 Fuxing Road, Haidian District, Beijing 100853, China Department of Pharmacy,State Key Laboratory of Biotherapy,West China Hospital,Sichuan University,Chengdu,China; Laboratory of Clinical Pharmacy and Adverse Drug Reaction,West China Hospital,Sichuan University,Chengdu,China Liver Cancer Institute and Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, China 1 National Laboratory of Solid State Microstructures Department of Materials Science and Engineering, Nanjing University, Nanjing 210093, People’s Republic of China; Collaborative Innovation Center of Advanced Microstructure, Nanjing University, Nanjing 210093, People’s Republic of China South China University of Technology 1 School of Chemistry and Chemical Engineering, , Guangzhou 510640, China Department of Liver Surgery and Transplantation Liver Cancer Institute Zhongshan Hospital Fudan University; Key Laboratory of Carcinogenesis and Cancer Invasion Shanghai Key Laboratory of Organ Transplantation Zhongshan Hospital Shanghai 200032 P. R. China College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 311121, China Department of MRI, The Third Affiliated Hospital of Qiqihar Medical University, Qiqihar, Heilongjiang 161000, P.R. China School of Materials Science and Engineering & Centre for Integrated Computational Materials Science, International Research Institute for Multidisciplinary Science, Beihang University, Beijing 100191, China Beijing Key Laboratory for Green Catalysis and Separation College of Environmental and Energy Engineering Beijing University of Technology Beijing 100124 P. R. China Organ Transplant Center First Affiliated Hospital Sun Yat‐sen University Guangzhou China West China School of Medicine, Sichuan University, Chengdu, Sichuan, China. Key Laboratory of Systems Bioengineering, Ministry of Education, School of Chemical Engineering and Technology, Tianjin University, Tianjin 300072, People's Republic of China. Department of Ano-Intestinal Surgery, Ningbo Fenghua District Peoples’ Hospital, Fenghua, Ningbo, China (mainland) Lyda Hill Department of Bioinformatics, University of Texas Southwestern Medical Center, Dallas, Texas, USA; Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, P. R. China; Institute of Biomedical Sciences, Fudan University, Shanghai 200032, P. R. China Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Fudan University, Ministry of Education, Shanghai 200032, P.R. China State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 200032 Shanghai, China Department of Radiology, Hangzhou Cancer Hospital School of Chemistry and Chemical Engineering; South China University of Technology; Guangzhou, China Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P.R. China Shanghai Research Institute of Petrochemical Technology, Sinopec, 201208 Shanghai, China; University of Houston, College of Pharmacy, Houston, Texas, USA Department of Medical Oncology Fuyang People's Hospital Fuyang China Institute of Immunology, PLA, Third Military Medical University (Army Medical University), Chongqing, PR China Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education),Fudan University,Shanghai,China; Institute of Biomedical Sciences,Fudan University,Shanghai,China; State Key Laboratory of Genetic Engineering,Fudan University,Shanghai,China Department of Orthopedics, The Second Xiangya Hospital; Department of Sports Medicine Research Center, Central South University, Changsha, Hunan, China. Liver Cancer Institute, Zhongshan Hospital, and Key Laboratory of Carcinogenesis and Cancer Invasion (Ministry of Education); Fudan University; Shanghai People's Republic of China; Institute of Biomedical Sciences; Fudan University; Shanghai People's Republic of China Department of Liver Surgery & Transplantation, Liver Cancer Institute, Zhongshan Hospital, Fudan University; Key Laboratory of Carcinogenesis & Cancer Invasion, Ministry of Education, Shanghai, China No. 4 Department of Biological Products, Institute of Medical Biology, Chinese Academy of Medical Sciences and Peking Union Medical College, Kunming, Yunnan, China Department of Vascular Surgery, Changhai Hospital, Second Military Medical University, Shanghai, People’s Republic of China State Key Laboratory of Chemical Engineering, College of Chemical and Biological Engineering, Zhejiang University, 38 Zheda Road, Hangzhou 310027, P. R. China Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan Second Affiliated Hospital of Wenzhou Medical University, Wenzhou, 325027, China. Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University Key Laboratory of Carcinogenesis and Cancer Invasion of Ministry of Education, Shanghai, China ; Institutes of Biomedical Sciences, Fudan University Shanghai, People's Republic of China. Department of Cardio‑Thoracic Surgery, Shanghai Tenth People's Hospital, School of Medicine, Tongji University, Shanghai 200072, P.R. China Shanghai Clinical Center for Diabetes, Department of Endocrinology and Metabolism, Shanghai Sixth People's Hospital Affiliated to Jiaotong University, Shanghai Diabetes Institute, Shanghai 200233, China. Center for Optics Research and Engineering, Shandong University, Qingdao 266237, P. R. China; Institute of Novel Semiconductors, Shandong University, Jinan 250100, P. R. China Liver Cancer Institution, Fudan University , Shanghai , China; Department of Liver Surgery, Zhongshan Hospital, Fudan University , Shanghai , China; Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education , Shanghai , China; Institute of Biomedical Sciences, Fudan University , Shanghai , China Articular Orthopaedics, The Third Affiliated Hospital of Soochow University, Changzhou 213000, Jiangsu Province, China.; Articular Orthopaedics, The Third Affiliated Hospital of Soochow University, Changzhou 213000, Jiangsu Province, China. Department of Orthopaedic Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China Department of Endocrinology and Metabolism, Shanghai Jiao Tong University, Affiliated Sixth People's Hospital, Shanghai, China. Department of Liver Surgery, Zhongshan Hospital, Fudan University Department of Vascular Surgery, Changhai Hospital, The PLA Naval Medical University , 168 Changhai Road , Shanghai 200433 , China Shanghai Key Laboratory of Green Chemistry and Chemical Processes; East China Normal University; Shanghai; P. R. China Boyce Thompson Institute at Cornell University, Ithaca, New York 14853; Department of Entomology, Cornell University, Ithaca, New York 14853 WuXi AppTec, 168 Nanhai Road, Tianjin Economic-Technological Development Area TEDA, Tianjin 300457, China Affiliated Hospital, Chengde Medical College, Chengde 067000, China Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School Fudan University, Key Laboratory for Carcinogenesis & Cancer Invasion, The Chinese Ministry of Education, Shanghai, People's Republic of China From the Department of Magnetic Resonance (Y.R., X.L., F.Z., X. Wang, S.X., J. Zhou, J.C.), First Affiliated Hospital of Zhengzhou University, China Key Laboratory of Novel Materials for Sensor of Zhejiang Province, College of Materials and Environmental Engineering, Hangzhou Dianzi University, Hangzhou 310018, P. R. China Hunan Province Key Laboratory of Animal Nutritional Physiology and Metabolic Process, Key Laboratory of Agro-ecological Processes in Subtropical Region, National Engineering Laboratory for Pollution Control and Waste Utilization in Livestock and Poultry Production, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Changsha, 410125 Hunan, China; University of Chinese Academy of Sciences, Beijing 100008, China Department of Pulmonary Medicine, Zhongshan Hospital, Fudan University, Shanghai, China; Shanghai Respiratory Research Institution, Shanghai, China Department of Thoracic Surgery, Peking University People's Hospital , Beijing, China Department of Radiology, Joint Security Forces 945 Hospital , Yaan 625000 , Sichuan , China College of Chemistry; Chongqing Normal University; Chongqing; P. R. China; Department of Chemistry Department of Orthopedics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China Department of Liver Surgery and Transplantation, Zhongshan Hospital, Fudan University, Shanghai, China; Liver Cancer Institute, Zhongshan Hospital, Fudan University, Shanghai, China The Department of Stomatology, the General Hospital, Tianjin Medical University, Tianjin 300052, China. State Key Laboratory for Strength and Vibration of Mechanical Structures, School of Aerospace Engineering, Xi’an Jiaotong University, Xi’an 710049, China Department of Nutrition and Food Hygiene, The Fourth Military Medical University of People’s Liberation Army, Xi'an, China. State Key Laboratory for Chemo/Biosensing and Chemometrics; College of Chemistry Institution; Hunan University; Changsha 410082; China State Key Laboratory of Microbial Resources, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, PR China Department of Orthopaedics, Zhongshan Hospital Affiliated to Fudan University, Shanghai 200032, China. Department of Orthopedics, First Affiliated Hospital, Anhui Medical University Department of Physics Virginia Commonwealth University Richmond; Virginia 23284; USA Shanghai Jiaotong University, Shanghai, China Department of General Surgery, the First Affiliated Hospital of Soochow University, Suzhou 215006, China Department of Endocrinology and Metabolism Shanghai Key Laboratory of Diabetes Mellitus Shanghai Jiao Tong University Affiliated Sixth People's Hospital Shanghai Clinical Center for Diabetes Shanghai Key Clinical Center for Metabolic Disease Shanghai Diabetes Institute Shanghai China Department of Liver Surgery, Liver Cancer Institute, Zhongshan Hospital, Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion, Ministry of Education, Shanghai 200032, P.R. China Department of Liver Surgery and Transplantation Liver Cancer Institute Zhongshan Hospital Fudan University Shanghai China; Key Laboratory of Carcinogenesis and Cancer Invasion Ministry of Education Shanghai China; Institute of Biomedical Sciences Fudan University Shanghai China Department of Thoracic Surgery , West China Hospital, Sichuan University, Chengdu, China; West China School of Medicine , Sichuan University, Chengdu, China Department of Chemical Engineering, University of Washington, Seattle, Washington 98195 Liver Cancer Institute, Zhongshan Hospital,Fudan University, Key Laboratory of Carcinogenesis and Cancer Invasion (Fudan University), Ministry of Education,Shanghai,China; Laboratory of Epigenetics,Institutes of Biomedical Sciences, Fudan University,Shanghai,China; Cancer Center, Institutes of Biomedical Sciences,Fudan University,Shanghai,China Department of Neurosurgery, Center of Epilepsy, Beijing Institute for Brain Disorders, Beijing Key Laboratory of Epilepsy Research, Sanbo Brain Hospital Capital Medical University Beijing China School of Chemistry and Chemical Engineering, South China University of Technology, Guangzhou, Guangdong 510640, China Princeton University, Princeton, New Jersey; Columbia University School of Medicine, New York City, New York Liver Cancer Institute, Zhongshan Hospital, Fudam University, Shanghai 200032, China. [email protected] International Joint Research Laboratory for Biointerface and Biodetection, State Key Lab of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, People’s Republic of China; School of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu, 214122, People’s Republic of China †Department of Medicine, University of Chicago, Chicago, IL 60637; Clinical Medical Research InstituteFirst Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina; State Key Laboratory Incubation Base of Xinjiang Major Diseases ResearchFirst Affiliated Hospital of Xinjiang Medical UniversityUrumqiChina Shanghai Key Laboratory of Green Chemistry and Chemical Processes School of Chemistry and Molecular Engineering East China Normal University Dongchuan Road 500 Shanghai 200241 China Department of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, Louisiana; Department of Orthopedics, The Second Xiangya Hospital of Central South University, Changsha, China Department of Liver Surgery and Transplantation, Liver Cancer Institute and Zhongshan Hospital, Fudan University, Shanghai, China Department of Neurosurgery the Affiliated Hospital of Southwest Medical University Luzhou China Department of Critical Care Medicine, Zhujiang Hospital |
Incoming Links
Showing number of triples: 1 to 1000 of 4188.
| Next Page | Last Page |