http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_bede690153577ce5538ef92f01ca4145
Outgoing Links
Predicate | Object |
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family-name | Xu Xin Xu |
name | Xin Xu |
given-name | Xin |
organization-name | Renal Division, Nanfang Hospital, Southern Medical University, The National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangzhou, China; Department of Biochemistry and Molecular Biology; University of Louisville Health Sciences Center; Louisville Kentucky Mikrobiologisches Institut Department of Cardiology, WuXi Second Hospital, Nanjing Medical University, 68 Zhongshan Road, Wuxi 214002, China Department of Clinical Epidemiology, Library Shengjing Hospital of China Medical University P.R. China Key Laboratory of Superlight Materials & Surface Technology, Ministry of Education, Institute of Advanced Marine Materials, College of Materials Science and Chemical Engineering, Harbin Engineering University, Harbin 150001, P. R. China Henan Provincial Engineering and Technology Center of Health Products for Livestock and Poultry, Nanyang Normal University, Nanyang 473061, China; Henan Key Laboratory of Insect Biology in Funiu Mountain, Nanyang Normal University, Nanyang 473061, China Department of Urology, China-Japan Friendship Hospital Institute of Space Medico-Engineering, Beijing, China. [email protected] School of Food and Biological Engineering Jiangsu University Zhenjiang China Department of Pharmacokinetics, Dynamics, and Metabolism and ‡Department of Analytical Research & Development, Pfizer Inc., Andover, Massachusetts, United States; Department of Immunology and Autoimmunity and ∥Department of Global Biotherapeutics Technologies, Pfizer Inc., Cambridge, Massachusetts, United States Drexel University 1 School of Biomedical Engineering, Science and Health Systems, , Philadelphia, Pennsylvania 19104, USA State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University, Chengdu 610041, China Department of Epidemiology and Health Statistics & Key Laboratory of Ministry of Education for Gastrointestinal Cancer Fujian Medical University Fuzhou Fujian P. R. China Affiliated Hospital of Weifang Medical University, Weifang 261031, Shandong, China. Department of Emergency, Hebei General Hospital, Shijiazhuang Hebei, China State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases& Department of Cariology and Endodon-tics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China Harvard Pilgrim Health Care Institute, Department of Population Medicine, Harvard Medical School, Boston, Massachusetts; Now with Takeda Pharmaceutical Company, Lexington, Massachusetts West China School of Public Health, Department of Public Health Laboratory Sciences Sichuan University Chengdu China From the Center for Vascular Biology (Z.L., X.X., G.Z., E.D.v.D., Y.C.) and Cardiovascular Division (Z.L., X.X., X.H., G.Z., P.Z., J.P.F., J.T.F., R.J.B., Y.C.), Department of Medicine, University of Minnesota Medical School, Minneapolis; Department of Pathology (T.D.O.), University of Pittsburgh Medical Center, University of Pittsburgh, Pa; and the Division of Experimental Cardiology (E.D.v.D.), Department of Cardiology, Cardiovascular Research School COEUR, Erasmus MC, University Medical Center... State Key Laboratory of Crop Biology, College of Horticulture Science and Engineering, Shandong Agricultural University, Tai’an, Shandong 271018, China Research Group of Water Pollution Control and Water Reclamation, College of Chemical Engineering, Beijing University of Chemical Technology, Beijing, People’s Republic of China Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin, China Henan Provincial Engineering Laboratory of Insects Bio‐reactor Henan Provincial Engineering and Technology Center of Health Products for Livestock and Poultry Nanyang Normal University Nanyang China Department of Cardiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310009, P. R. China. Email: [email protected]. Faculty of Psychology Beijing Normal University Beijing China The Second Affiliated Hospital and School of Public Health, Zhejiang University School of Medicine, Zhejiang, China; Memory Aging & Cognition Centre, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore State Key Laboratory of Molecular Oncology, Cancer Institute (Hospital), Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China. Department of Anesthesiology, Beijing Tongren Hospital Capital Medical University Beijing China National Center for Advancing Translational Sciences, National Institutes of Health , Rockville, MD 20850 , USA College of Physical Education and Health, Guangxi Normal University, Guilin 541004, China Program of Population Genetics (Y.F., Xin.X.), Harvard School of Public Health, Boston, Massachusetts 02115 From the Cardiovascular Division (X.X., J.F., Y.L., R.J.B., Y.C.) and Vascular Biology Center (X.H., G.Z., Z.L., Y.C.), Department of Medicine, University of Minnesota Medical School, Minneapolis; and the National Institute of Diabetes and Digestive and Kidney Diseases (J.S.), National Institutes of Health, Bethesda, Md. College of Materials Science and Engineering, Nanjing Tech University, Nanjing 210009, PR China; Jiangsu Collaborative Innovation Center for Advanced Inorganic Function Composites, Nanjing Tech University, Nanjing 210009, PR China Air Force Logistics Academy Xuzhou Jiangsu 221000 China State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China From the Yunnan Province Key Laboratory for Tropical Infectious Diseases in Universities; Department of Biochemistry and Molecular Biology , Kunming Medical University Department of Thoracic Surgery/Oncology, State Key Laboratory, and National Clinical Research Center for Respiratory Disease, School of Geography and Biological Information, Nanjing University of Posts and Telecommunications, Nanjing 210023, P. R. China Chinese Academy of Sciences State Key Laboratory of Molecular Reaction Dynamics and Center for Theoretical Computational Chemistry, Dalian Institute of Chemical Physics, , Dalian 116023, People's Republic of China State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China; Department of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China Birck Nanotechnology Center; School of Mechanical Engineering Shanghai Municipal Hospital of Traditional Chinese Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200071, P.R. China Joint International Research Laboratory of Resource Chemistry of Ministry of Education, Shanghai Key Laboratory of Rare Earth Functional Materials, and Shanghai Frontiers Science Center of Biomimetic Catalysis, Shanghai Normal University, Shanghai 200234, China Department of Orthopedic Surgery, The People’s Hospital of Yuxi City, The 6th Affiliated Hospital of Kunming Medical University, Yuxi, Yunan, China (mainland) McLaughlin Research Institute for Biomedical Sciences, Great Falls, MT 59405, USA Department of Medical Oncology The First Affiliated Hospital of Zhejiang University Hangzhou China Department of Clinical Epidemiology, Shengjing Hospital of China Medical University , Shenyang, China; Liaoning Key Laboratory of Precision Medical Research on Major Chronic Disease , Shenyang, China 1Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, P.R. China. Key Laboratory of Theoretical Chemistry and Molecular Simulation of Ministry of Education, Hunan Province College Key Laboratory of QSAR/QSPR, School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan, Hunan 411201, China School of Materials Science and Engineering Shandong University of Technology Zibo 255000 P. R. China Chinese Academy of Sciences Key Laboratory of Materials for Energy Conversion, Department of Materials Science and Engineering, University of Science and Technology of China, Jinzhai Road 96, Hefei Anhui 230026, People’s Republic of China Key Laboratory of Molecular Feed Sciences, Institute of Animal Nutrition and Feed Sciences, College of Animal Sciences Zhejiang University Zhejiang 310058 China Affiliated Hangzhou First People’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China; Liangzhu Laboratory, Zhejiang University, Hangzhou 310012, China Department of Pathogen Biology and Immunology, Kunming Medical University, Kunming, China; Department of Microbiology and Immunology School of Basic Medical Sciences Kunming Medical University Kunming 650500China Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China; School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang 110016, China Department of Rehabilitation Therapy, School of Health, Shanghai Normal University Tianhua College Shanghai, China. Henan Provincial Engineering Laboratory of Insects Bio-reactor, Henan Provincial Engineering and Technology Center of Health Products for Livestock and Poultry, Nanyang Normal University , Nanyang , , PR China Department of Pharmaceutical Sciences; Zunyi Medical University, Zhuhai Campus; Zhuhai Guangdong 519041 PR China Department of Chemistry, University of Minnesota, Minneapolis, Minnesota 55455 Department of Plant Pathology, College of Plant Protection China Agricultural University Beijing China Worldwide Research and Development, Pfizer Inc., 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, United States Department of Chemistry, The Hong Kong University of Science and Technology, 999077 Clear Water Bay, Kowloon, Hong Kong, P. R. China Department of Chemistry, The University of Minnesota, Minneapolis, Minnesota; From the Departments of Cardiology (F.F., L.Q., J.J., Y.Y., J.L., Y.Z., Y.H.) and Clinical Laboratory (H.L.), Peking University First Hospital, Beijing, China; State Key Laboratory for Organ Failure Research, Renal Division, National Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangzhou, China (X.X., X.Q.); and Department of Emergency, Tsinghua University, YuQuan Hospital, Beijing, China (Y.L.). 1Department of Implantology, School of Stomatology, Shandong University, Jinan, People’s Republic of China; 2Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, People’s Republic of China Department of Neurology The First Affiliated Hospital of Chongqing Medical University Chongqing Key Laboratory of Neurology Chongqing China Ministry of Agricultural Scientific Observing and Experimental Station of Maize in Plain Area of Southern Region, School of Life Sciences, Nantong University, Nantong, Jiangsu, China Department of General Surgery, Second Hospital, Xi'an Jiaotong University, 157 Northern street, Xi'an 710004, Shaanxi Province, China. [email protected] Jiangxi Province Key Laboratory of Preventive Medicine School of Public Health Department of Cardiovascular Medicine The Second Affiliated Hospital Nanchang University Nanchang P. R. China Haohua Technology Co., Ltd, Shanghai, China Department of Pharmacology, Clinical Research Centre, National University Health System, National University of Singapore, Singapore; Memory Ageing and Cognition Centre, National University Health System, Singapore School of Stomatology, Shandong University, Jinan 250012, Shandong Province, China. [email protected] State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China National Clinical Research Center for Respiratory Disease The First Affiliated Hospital of Guangzhou Medical University Guangzhou China; Department of Thoracic Surgery The First Affiliated Hospital of Guangzhou Medical University Guangzhou China From the Cardiovascular Division (X.H., X.X., J.F., R.J.B., Y.C.) and Vascular Biology Center (X.H., X.X., Y.C.), Department of Medicine, University of Minnesota Medical School, Minneapolis; An Zhen Hospital (Y.H., Y.Z.), Beijing, China; and Cell Biology and Physiology (T.P.F., C.G.N.), Washington University School of Medicine, St Louis, Mo. Key Laboratory for Analytical Science of Food Safety and Biology of the MOE; Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety; State Key Laboratory of Photocatalysis on Energy and Environment; College of Chemistry; Fuzhou University Department of Neurosurgery, Chinese PLA General Hospital, Beijing, China Shanghai Institute of Thoracic Oncology Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine Shanghai China College of Polymer Science & Engineering, State Key Laboratory of Polymer Materials Engineering, Sichuan University, Chengdu 610065, China Collaborative Innovation Center of Chemistry for Energy Materials, Fudan University, Shanghai 200433, China;; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Fudan University, Shanghai 200433, China; MOE Key Laboratory of Computational Physical Sciences, Fudan University, Shanghai 200433, China; Department of Chemistry, Fudan University, Shanghai 200433, China Department of Applied Chemistry, School of Science, State Key Laboratory for Mechanical Behavior of Materials, Xi’an Jiaotong University, Xi’an 710049, China Department of Implantology, Shandong Provincial Key Laboratory of Oral Biomedicine, Shandong University School of Stomatology, Jinan, Shandong, China. [email protected]. Fudan University Collaborative Innovation Center of Chemistry for Energy Materials, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, MOE Laboratory for Computational Physical Science, Department of Chemistry, , Shanghai 200433, China School of Stomatology, Shandong University, Jinan 250012, China;Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan 250012, China;Dept. of Implantology, Stomatological Hospital of Shandong University, Jinan 250012, China. From the College of Life Sciences, University of Chinese Academy of Science, Beijing, China (Z.L.); Cardiovascular Division and Lillehei Heart Institute (Z.L., X.X., J.F., D.K., X.L., X.H., H.W., H.G., D.X., S.Y., F.L., R.J.B., Y.C.) and Cardiology and Cardiothoracic Surgery Sections, VA Medical Center (E.O.M.), University of Minnesota, Minneapolis; and Institute of Molecular Medicine, Peking University, Beijing, China (X.H.). School of Chemical Engineering and Advanced Materials The University of Adelaide Adelaide SA 5005 Australia State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases Department of Cariology and Endodontics West China Hospital of Stomatology Sichuan University Chengdu China The Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, The Chinese Ministry of Education, Shanghai, P.R. China Henan Province Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases, School of Pharmaceutical Sciences, Zhengzhou University, No. 100 Science Avenue, Zhengzhou, Henan 450001, P. R. China Renal Division, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangzhou, China School of Stomatology Shandong Provincial Key Laboratory of Oral Tissue Regeneration Shandong University Jinan 250012 China Center for Reproductive Medicine Cheeloo College of Medicine Shandong University Jinan China; Key Laboratory of Reproductive Endocrinology of Ministry of Education Shandong University Jinan China; Shandong Key Laboratory of Reproductive Medicine Jinan China; Shandong Provincial Clinical Research Center for Reproductive Health Jinan China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics Shandong University Jinan China DICP-CMC Innovation Institute of Medicine, Taizhou 225300, China. The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China; Guangzhou Institute of Respiratory Disease & China State Key Laboratory of Respiratory Disease, Guangzhou, China Department of Cardiology, Affiliated Hospital of Qinghai University, Xining 810000, China. State Key Laboratory for Physical Chemistry of Solid Surfaces; Center for Theoretical Chemistry, Department of Chemistry, Xiamen University, Xiamen 361005, China; Materials and Process Simulation Center, Beckman Institute (139-74), Division of Chemistry and Chemical Engineering, California Institute of Technology, Pasadena, California 91125 Institute of Respiratory Diseases, First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, China. [email protected] Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University Singapore 637371 Singapore Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan; and; Department of Digestive Diseases, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China Department of Emergency Key Laboratory of Biomedical Engineering of Hainan Province, School of Biomedical Engineering Hainan University Haikou China Department of Epidemiology, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Jiangsu Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, China Laboratory of Stem Cells and Regeneration Medicine, The Affiliated Hospital of Weifang Medical University, Weifang 261041, Shandong Province, China. Clinical School of Weifang Medical College, Weifang 261041, Shandong Province, China. Memory Aging and Cognition Centre, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore , Singapore, 119228 , Singapore; School of Public Health, and the 2nd Affiliated Hospital, Zhejiang University School of Medicine , Hangzhou, Zhejiang, 311100 , China State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, Shanghai Jiao Tong University School of Medicine, and Key Laboratory of Systems Biomedicine of Ministry of Education, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200025, China; Beijing Hospital of Traditional Chinese Medicine, Capital Medical University, Beijing, China (mainland) Key Laboratory of Bio-Inspired Smart Interfacial Science and Technology of Ministry of Education; School of Chemistry; Beihang University; Beijing 100191; China Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Ministry of education (MOE) Laboratory for Computational Physical Science, Fudan University, Shanghai 200433, China;; State Key Laboratory of Physical Chemistry of Solid Surfaces, College for Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China; Department of Materials Science and Engineering, and Department of Physics, Fujian Key Laboratory of Plasma and Magnetic Resonance, Xiamen University, Xiamen 361005, China and Department of Chemistry, State Key Laboratory of Physical Chemistry of Solid Surfaces, Xiamen University, Xiamen 361005, China State Key Laboratory of Molecular Oncology Cancer Institute/Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China Department of Applied Chemistry School of Science State Key Laboratory for Mechanical Behavior of Materials MOE Key Laboratory for Nonequilibrium Synthesis, and Modulation of Condensed Matter Xi'an Jiaotong University Xi'an 710049 P. R. China Guangdong Provincial Key Laboratory of Optical Fiber Sensing and Communications; and Siyuan Laboratory; Guangdong Provincial Engineering Technology Research Center of Vacuum Coating Technologies and New Energy Materials; Department of Physics; Jinan University Key Laboratory of Functional Inorganic Material Chemistry, Ministry of Education of the People’s Republic of China, School of Chemistry and Materials Science, Heilongjiang University, Harbin 150080, China Program for Popular Genetics, Harvard School of Public Health, Boston, Massachusetts Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama;; Birmingham VA Medical Center, University of Alabama at Birmingham, Birmingham, Alabama;; Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, Alabama; and Department of General Surgery, Jiangning Hospital, Nanjing, Jiangsu, China Beijing Genomics Institute/Center of Genomics and Bioinformatics, Chinese Academy of Sciences, Beijing 101300, China. Department of Orthopedics, Huzhou Cent Hosp, Affiliated Cent Hosp Huzhou University Huzhou 313000, Zhejiang, China. School of Stomatology, Shandong University, Jinan, Shandong Province, China 1Rapid Novor, Inc., Kitchener, Ontario, Canada. People’s Hospital of Shijiazhuang, Shijiazhuang, China. MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou 350116, P. R. China Shaanxi Institute of Flexible Electronics (SIFE) Northwestern Polytechnical University (NPU) Xi'an 710129 China; Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University Singapore 637371 Singapore Division of Pre-Clinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States School of Stomatology; Shandong University; Jinan; China; Shandong Provincial Key Laboratory of Oral Biomedicine Office on Smoking and Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, Georgia Division of Pre-clinical Innovation, National Center for Advancing Translational Sciences (NCATS), National Institutes of Health (NIH), Rockville, Maryland 20850, United States Key Laboratory for Renewable Energy; Beijing Key Laboratory for New Energy Materials and Devices, and Institute of Physics; Chinese Academy of Sciences; Beijing 100190 P. R. China College of Food Science and Engineering, Yangzhou University, Yang Zhou 225127, China Department of Dermatology, Shanghai Skin Disease Hospital, Shanghai, P. R. China School of Life Sciences, Qufu Normal University, Qufu, Shandong 273165, China Department of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, China Key Laboratory of Plant Hormones and Development Regulation of Chongqing, School of Life Sciences, Chongqing University, Chongqing 400044, China; Center of Plant Functional Genomics, Institute of Advanced Interdisciplinary Studies, Chongqing University, 401331 Chongqing, China Key Laboratory of Pesticide and Chemical Biology (CCNU) of Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, China, State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Center for Theoretical Chemistry, Xiamen University, Xiamen 361005, China, and Department of Pharmacology, Basic Medical School of Wuhan University, Wuhan 430071, China Chemical and Screening Sciences, Drug Safety and Metabolism, and Cardiovascular and Metabolic Diseases, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140 Departments of Medicine and Integrative Biology/Physiology, University of Minnesota Medical School, Minneapolis, Minnesota; and State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University , Chengdu 610041 , P. R. China China National Clinical Research Center of Respiratory Diseases Respiratory Department of Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China Department of Mechanical Engineering University of Maryland College Park MD 20742 USA Applied Physics, Northwestern University; Evanston; USA Department of Thoracic Surgery/Oncology, State Key Laboratory and National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, China Department of Dentistry, Affiliated Hospital, Weifang Medical University, Weifang, Shandong Province, PR China Chinese PLA General Hospital State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, People's Republic of China College of Food Science and Engineering, Yangzhou University, Yangzhou, Jiangsu 225127, People’s Republic of China Siyuan Laboratory, Guangdong Provincial Engineering Technology Research Center of Vacuum Coating Technologies and New Energy Materials, Department of Physics, Jinan University, Guangzhou, Guangdong 510632, Peopleʼs Republic of China National Engineering Research Center for the Emergency Drug Beijing Institute of Pharmacology and Toxicology Beijing 100850 China Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, MD 20892, USA. CAS Key Laboratory of Materials for Energy Conversion; Department of Materials Science and Engineering; University of Science and Technology of China; Hefei 230026; China State Key Laboratory for Physical Chemistry of Solid Surfaces, Center for Theoretical Chemistry, Department of Chemistry, Xiamen University, Xiamen 361005, China; Materials and Process Simulation Center (139-74), California Institute of Technology, Pasadena, California 91125 Department of Preventive Medicine and Public Health Laboratory Science, School of Medicine, Jiangsu University, Zhenjiang 212013, China From the Departments of Vascular Surgery (Z.H.D., W.G.F., Y.Q.W., D.Q.G., X.X., B.C., J.H.J., J.Y., Z.Y.S., T.Z., Y.S.) and Pathology (Y.J.), Zhongshan Hospital, Fudan University, Shanghai, China. Department of Chemistry The Hong Kong University of Science and Technology Clearwater Bay, Kowloon Hong Kong 999077 China Psychology Division, School of Sport, Exercise and Health Sciences, Loughborough University, Loughborough, UK; Memory, Ageing and Cognition Center, Department of Pharmacology, National University of Singapore, Singapore Heat Biologics, Inc., Durham, North Carolina. Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors, Institute of Advanced Materials (IAM), Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM), Nanjing University of Posts & Telecommunications, 9 Wenyuan Road, Nanjing 210023, China National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology & Toxicology, Beijing, 100850, China Department of Neurology, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, 1 Youyi Road, Chongqing, China Department of Neurosurgery, Xuanwu Hospital, International Neuroscience Institute Capital Medical University Beijing China School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China From the Lillehei Heart Institute (X.H., X.X., P.Z., H.G., Z.L., J.F., R.J.B., Y.C.) and Cardiovascular Division (X.H., X.X., P.Z., H.G., Z.L., J.F., R.J.B., Y.C.), University of Minnesota Medical School, Minneapolis, MN; Institute of Experimental and Clinical Pharmacology and Toxicology, University Hospital Hamburg, Eppendorf, Germany (D.A., E.S., R.H.B.). Therapeutic Development Branch, and Key Laboratory of Energy Materials and Devices (Liaoning Province), School of Materials Science and Engineering, Dalian University of Technology, Dalian 116024, China State Key Laboratory of Crop Stress Biology for Arid Areas and College of Agronomy, Northwest A&F University, Yangling, Shaanxi 712100, China National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland 20850, United States Division of Pre-Clinical Innovations, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland Division of Pre-Clinical Innovations, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States Memory Ageing and Cognition Centre (MACC), National University Health System, Singapore; Department of Pharmacology, National University of Singapore, Singapore; Centre for Population Health Sciences, Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore Department of Enterocutaneous Fistula Surgery Jiangning Hospital Nanjing Jiangsu China Xinzhou Orthopedics Hospital, Wuhan 430400, Hubei, China. From the Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China (Y.L., M.L., G.W., B.W., X.X., F.F.H., X.Q.); National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangzhou, China (Y.L., M.L., G.W., B.W., X.X., F.F.H., X.Q.); Department of Neurology, First People’s Hospital, Lianyungang, China (M.H.); Institute for Biomedicine (G.T.) and Department of Health Administration,... Program for Population Genetics Harvard School of Public Health Boston, Massachusetts Department of Chemistry, Lab of Advanced Materials, Fudan University, 2205 Songhu Road, Shanghai 200438, P. R. China Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Japan; Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, China Huaxi MR Research Center (HMRRC), Department of Radiology, West China Hospital of Sichuan University, Chengdu 610041, China Department of General Surgery, The Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China Key Laboratory of Feed Biotechnology of Ministry of Agriculture and Rural Affairs, Institute of Feed Research, Chinese Academy of Agricultural Sciences, Beijing 100081, China State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, P.R. China Department of Neurosurgery, PLA General Hospital, PLA Postgraduate Medical School, Beijing; and Tianjin Key Laboratory of Digestive Diseases, Department of Gastroenterology and Hepatology Tianjin Institute of Digestive Diseases, National Key Clinical Specialty, General Hospital, Tianjin Medical University Tianjin China From the Division of Cardiology, University of Minnesota Medical School, Minneapolis, MN. Taizhou Key Laboratory of Medical Devices and Advanced Materials, Research Institute of Zhejiang University-Taizhou, Taizhou 318000, China Zhengzhou University, China Department of Rehabilitation, Children's Hospital of Nanjing Medical University, Nanjing, Jiangsu 210008, China. [email protected]. From the Centre for Healthy Brain Ageing (CHeBA) (J.W.L., J.D.C., H.B., D.M.L., B.C.P.L., P.S.S.), UNSW, Sydney, Australia; No affiliation (D.W.D.); Department of Neurology (H.-J.B.), Seoul National University School of Medicine, Seoul National University Bundang Hospital, Seongnam; Department of Neurology (J.-S.L.), Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea; Department of Neurology and Laboratory of Functional Neurosciences (O.G., M.R.), University Hospital of... Laboratory for Stem Cell and Regenerative Medicine The Affiliated Hospital of Weifang Medical University Weifang Shandong China; College of Bioscience and Technology Weifang Shandong China State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China Department of Hematology and Oncology, Beilun District People’s Hospital, Ningbo, China Shanghai Institute of Thoracic Oncology Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine Shanghai 200030 P. R. China State Key Laboratory of Oral Diseases, Department of Orthodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China Hefei University of Technology (HFUT) 1. Ganjiang Chinese Medicine Innovation Center,Nanchang 330000,China;2. Jiangxi Provincial Key Laboratory for Pharmacodynamic Material Basis of Traditional Chinese Medicine,Nanchang 330000,China. Shandong Provincial Key Laboratory of Oral Tissue Regeneration School of Stomatology Shandong University Jinan China Department of Urology Huai'an Cancer Hospital Huai'an Jiangsu China Department of Neurology, Daqing Oilfields General Hospital Daqing, China. School of Life Sciences, Zhengzhou University, Zhengzhou, China School of Stomatology Weifang Medical University Weifang People's Republic of China Drug Safety and Metabolism Department of Cardiology, Jiangnan University Medical Center (JUMC), Wuxi 214002, China Hangzhou Institute of Advanced Studies, Zhejiang Normal University, 1108 Gengwen Road, Hangzhou, Zhejiang, 311231, China Department of Chemistry, Laboratory of Advanced Materials, Fudan University, 2205 Songhu Road, Shanghai 200438, P.R. China College of Life Sciences, Capital Normal University, Beijing 100048, China State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chengdu, Sichuan, China; Department of Cariology and Endodontics, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China Key Laboratory of Molecular Animal Nutrition, Ministry of Education, Institute of Feed Science, College of Animal Science Zhejiang University Hangzhou China State Key Laboratory of Electrical Insulation and Power Equipment School of Electrical Engineering Xi'an Jiaotong University 28 West Xianning Road Xi'an 710049 China Institute of Applied Ecology, Chinese Academy of Sciences, Shenyang 110016, China. University of Chinese Academy of Sciences, Beijing 100049, China. Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials Ministry of Education (MOE) Laboratory for Computational Physical Science, Department of Chemistry, Fudan University Shanghai 200433 People's Republic of China Department of Chemistry, Renmin University of China, Beijing 100872, China Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409-1061 MOE Key Laboratory for Analytical Science of Food Safety and Biology, Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, State Key Laboratory of Photocatalysis on Energy and Environment, College of Chemistry, Fuzhou University, Fuzhou 350108, People’s Republic of China College of Life Science and Technology, Xinjiang University, Urumqi 830046, Xinjiang, China. Department of Environment Science and Engineering, Tsinghua University, Beijing 100084, China. [email protected] School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798; Department of Chemistry, University of Massachusetts Lowell, Lowell, Massachusetts 01854, United States Department of Pathology, Xingtai People’s Hospital Affiliated to Hebei Medical University, Xingtai, Hebei, P.R. China. State Key Laboratory of Respiratory Disease National Clinical Research Center for Respiratory Disease National Center for Respiratory Medicine Guangzhou Institute of Respiratory Health The First Affiliated Hospital of Guangzhou Medical University Guangzhou China State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian 116023, Liaoning, China; University of Chinese Academy of Sciences, Beijing 100049, China Department of Laboratory Science of Public Health, West China School of Public Health and West China Fourth Hospital Sichuan University 17#, Section 3, Renmin Nan Road Chengdu Sichuan 610041 P. R. China; Department of Public Health Laboratory Sciences, Food Safety Monitoring and Risk Assessment Key Laboratory of Sichuan Province West China School of Public Health Sichuan University 17#, Section 3, Renmin Nan Road Chengdu Sichuan 610041 P. R. China Department of Pharmacology, National University of Singapore, Singapore, Singapore; Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, China; Tianjin Institute of Digestive Disease, Tianjin Medical University General Hospital, Tianjin, China Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing 100191, P.R. China College of Energy Storage Technology, Shandong University of Science and Technology, Qingdao 266590, China School of Science, Xi’an Polytechnic University, Xi’an, China Department of Chemistry Fudan University Shanghai 200433 China Jidong Huang is with Institute for Health Research and Policy, University of Illinois at Chicago. Brian A. King, Stephen D. Babb, and Xin Xu are with the Office on Smoking and Health, Centers for Disease Control and Prevention, Atlanta, GA. Cynthia Hallett and Maggie Hopkins are with American Nonsmokers’ Rights Foundation, Berkeley, CA. Department of Oral and Maxillofacial Surgery, The Second Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China. [email protected] Collaborative Innovation Center of Chemistry for Energy Materials, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Ministry of Education Key Laboratory of Computational Physical Sciences, Department of Chemistry Fudan University Shanghai China; Hefei National Laboratory Hefei China College of Food Science and Engineering, Yangzhou University, Yangzhou 225127, China School of Life Science, Chongqing University, Chongqing, China Division of Nephrology, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University , Guangzhou , China Department of Obstetrics and Gynecology, The Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China Liver Cancer Institute, Zhongshan Hospital; Key Laboratory of Carcinogenesis and Cancer Invasion Fudan University, Ministry of Education Department of Gastroenterology The First Affiliated Hospital of Nanchang University Nanchang China; JiangXi Clinical Research Center for Gastroenterology Nanchang China a The Research Centre of Eco‐environmental Science , Zhejiang University , 268th KuanXian Avenue, Hangzhou 310029 , China Department of Materials Science and Engineering, University of Science and Technology of China, Hefei 230026, China Program for Population Genetics, Harvard School of Public Health, 667 Huntington Ave, Boston, MA 02115, USA. State Key Laboratory of Molecular Oncology, Cancer Institute (Hospital), Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100021, China Xiamen University 1 State Key Laboratory of Physical Chemistry of Solid Surfaces, Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, College of Chemistry and Chemical Engineering, , Xiamen 361005, China; Fudan University 2 MOE Laboratory for Computational Physical Science, Department of Chemistry, , Shanghai 200433, China Zhongshan Hospital, Department of Vascular Surgery, Fudan University, Shanghai, China Key Laboratory for Renewable Energy Beijing Key Laboratory for New Energy Materials and Devices Institute of Physics Chinese Academy of Sciences Beijing 100190 China Department of Laboratory Medicine The First Affiliated Hospital of Xi’an Jiaotong University Xi’an China Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland 4072, Australia Contribution from the State Key Laboratory of Physical Chemistry of Solid Surfaces and Center for Theoretical Chemistry, Department of Chemistry and Institute of Physical Chemistry, Xiamen University, Xiamen, 361005, China School of Chemical Science and Technology, Yunnan University, Kunming 650091, China Contribution from the State Key Laboratory for Physical Chemistry of Solid Surfaces & Center for Theoretical Chemistry, Institute of Physical Chemistry, Department of Chemistry, Xiamen University, Xiamen 361005, China National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China; Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham School of Medicine, Birmingham, Alabama, USA Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China; National Center for Advancing Translational Sciences National Institutes of Health Rockville Maryland United States Division of Clinical Immunology and Rheumatology Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, P. R. China Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China Department of Radiation Oncology, The Second Affiliated Hospital of Shandong First Medical University, Tai’an 271000, Shandong Province, China National Clinical Research Study Center for Kidney Disease State Key Laboratory for Organ Failure Research Renal Division Nanfang Hospital Southern Medical University Guangzhou China Department of General Surgery Second Affiliated Hospital School of Medicine Xi'an Jiaotong University Xi'an China Xiamen University State Key Laboratory of Physical Chemistry of Solid Surfaces, , Xiamen 361005, Fujian, People’s Republic of China and Department of Chemistry, College of Chemistry and Chemical Engineering, , Xiamen 361005, Fujian, People’s Republic of China; Xiamen University State Key Laboratory of Physical Chemistry of Solid Surfaces, , Xiamen 361005, Fujian, People’s Republic of China and Department of Chemistry, College of Chemistry and Chemical Engineering, , Xiamen 361005, Fujian, People’s Republic of China The Liver Cancer Institute, Zhongshan Hospital and Shanghai Medical School, Fudan University, Key Laboratory for Carcinogenesis and Cancer Invasion, The Chinese Ministry of Education, Shanghai, People's Republic of China Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University , Chengdu, P.R. China; Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University , Chengdu, P.R. China Department of Cardiology, YueBei People's Hospital Affiliated to Shantou University, Shaoguan 512026, China. Pfizer Research and Development, Cambridge, Massachusetts 02140, United States Department of Cardiothoracic Surgery, the First Affiliated Hospital of Guangzhou Medical College, Guangzhou, Guangdong, China; Guangzhou Institute of Respiratory Disease, Guangzhou, Guangdong, China. China State Key Laboratory of Respiratory Disease, Guangzhou, China. Key Laboratory of Atherosclerosis in Universities of Shandong and Institute of Atherosclerosis Taishan Medical University Shandong 271000 China From the Cardiovascular Division (Z.L., X.X., X.H., S.L., G.Z., J.F., Y.T., P.Z., M.P., J.L.H., D.J.G., Y.C.), Center for Vascular Biology (Z.L., X.X., Y.C.), and Lillehei Heart Institute (X.H., J.L.H., D.J.G., Y.C.), Developmental Biology Center (J.L.H.), University of Minnesota, Minneapolis; Minneapolis Heart Institute Foundation at Abbott Northwestern Hospital (J.H.T.), Minneapolis, Minn; and Department of Anatomy and Histology (C.d.R.), University of Sydney, Sydney, Australia. School of Education, Tianjin University, Tianjin, People’s Republic of China; Institute of Applied Psychology, Tianjin University, Tianjin, People’s Republic of China Memory Aging and Cognition Centre National University of Singapore Singapore Singapore; Department of Pharmacology, Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore School of Public Health, the Second Affiliated Hospital Zhejiang University School of Medicine Hangzhou Zhejiang China Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China Department of Molecular Sciences; Macquarie University; Sydney; Australia State Key Laboratory of Reproductive Medicine, Nanjing Medical University, Nanjing 211166, Jiangsu, China; Department of Maternal, Child and Adolescent Health, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing 211166, China. Department of Chemistry and Biomolecular Sciences, Macquarie University, Sydney, NSW, Australia Department of Urology, China-Japan Friendship Hospital, Beijing, 100029, People’s Republic of China Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin Institute of Digestive Diseases, Tianjin Key Laboratory of Digestive Diseases, Tianjin 300052, P.R. China From the Lillehei Heart Institute and Cardiovascular Division (D.X., H.G., X.X., Z.L., J.F., X.H., R.J.B., Y.C.), University of Minnesota Medical School, Minneapolis, MN; Department of Cardiology (D.X., Y.X.), Shanghai Tenth People's Hospital of Tongji University, Shanghai, China; Department of Cardiology (H.G., Q.T.), Renmin Hospital of Wuhan University, Wuhan, China; Pediatric Critical Care Medicine (A.S.), University of Minnesota, Minneapolis, MN; Human and Molecular Genetics Center (A.M.G.),... Cardiovascular Division and From the Lillehei Heart Institute and Division of Cardiology, Department of Medicine, University of Minnesota, Minneapolis (X.H., X.X., G.Z., P.Z., Y.C.); Clinical Pharmacology Unit, Institute of Experimental and Clinical Pharmacology, University Hospital Hamburg-Eppendorf, Hamburg, Germany (D.A., E.S., N.L., R.H.B.); Department of Nutritional Science, Okayama Prefectural University, Soja, Okayama, Japan (M.K.); and Department of Medicine, University of California, San Diego (J.C.). Texas Children's Cancer Center, Department of Pediatrics Dan L. Duncan Cancer Center, Baylor College of Medicine Houston USA Department of Implantology, School and Hospital of Stomatology, Shandong University & Shandong Provincial Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Shandong University, Jinan, Shandong, China Guangdong Provincial Key Laboratory of Allergy & Immunology; The State Key Laboratory of Respiratory Disease; The Second Affiliated Hospital; Guangzhou Medical University; Guangzhou 510260, P.R. China Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, MOE Laboratory for Computational Physical Science Fudan University Shanghai 200433 China; Department of Chemistry, College for Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China Human Saliva Laboratory of State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu Sichuan China PCFM, LIFM and GD HPPC Lab, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, P. R. China 1 Department of Developmental Biology, National Institute for Basic Biology; 2 Department of Molecular Biomechanics, Graduate University for Advanced Studies, Myodaiji, Okazaki 444, Japan Institute of Vascular Surgery, Department of Vascular Surgery Zhongshan Hospital, Fudan University 180 Fenglin Road 200032 Shanghai China Health Policy Center at the Institute of Health Research and Policy, University of Illinois at Chicago, Chicago, Illinois. Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medical Institutions, Baltimore, Maryland Department of Cardiology Affiliated Hospital of Nanjing Medical University Wuxi No. 2 People's Hospital Wuxi Jiangsu China School of Public Health and the 2nd Affiliated Hospital of School of Medicine, Zhejiang University, Hangzhou, China; Memory, Ageing and Cognition Centre, Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore College of Chemical Engineering, Zhejiang University of Technology, Zhejiang, Hangzhou 310014, P. R. China Advaccine Biopharmaceutics (Suzhou) Co., Ltd., Suzhou 215123, China 0000 0001 0708 1323 grid.258151.a Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology Jiangnan University 214122 Wuxi People’s Republic of China; 0000 0001 0708 1323 grid.258151.a State Key Laboratory of Food Science and Technology Jiangnan University 214000 Wuxi People’s Republic of China; 0000 0001 0708 1323 grid.258151.a School of Biotechnology Jiangnan University No. 1800, Lihu Avenue 214122 Wuxi Jiangsu People’s Republic of China From the Renal Division, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Guangzhou, China (X.Q., Y.L., X.X., M.L., J.N., B.W., F.F.H.); Department of Cardiology, Peking University People’s Hospital, Beijing, China (N.S.); Centers for Metabolic Disease Research, Temple University School of Medicine, PA (H.W.); Department of Cardiology, Peking University First Hospital, Beijing, China (Y.Z., J.L., Y.H... Departments of Physics and Chemistry, State Key Laboratory of Physical Chemistry of Solid Surface, Xiamen University, Xiamen 361005, P.R. China Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine Department of Thoracic Oncology and Surgery, China State Key Laboratory of Respiratory Disease and National Clinical Research Center for Respiratory Disease, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong 510120, China. Key Laboratory of Systems Biomedicine (Ministry of Education), Shanghai Center for Systems Biomedicine Shanghai Jiao Tong University Shanghai 200240 China; Department of Pharmacognosy, Center of Excellence for Chinmedomics Heilongjiang University of Chinese Medicine Harbin 150040 China Department of Urology, China-Japan Friendship Hospital, Yinghuadong Road, Chaoyang District, Beijing 100029, China Department of Biochemistry and Molecular Biology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), the Province and Ministry Co-sponsored Collaborative Innovation Center for Medical Epigenetics, Tianjin Medical University, Tianjin, P. R. China From the Cardiovascular Division and Lillehei Heart Institute (H.W., X.X., J.F., D.K., X.L., X.H., R.J.B., Y.C.) and Pulmonary Division (P.B.), University of Minnesota Medical School, Minneapolis; Shanghai Tenth People’s Hospital of Tongji University, Shanghai, China (X.L.); Institute of Molecular Medicine, Peking University, Beijing, China (X.H.); Ottawa Hospital Research Institute, Ottawa, ON, Canada (T.J.F., J.C.B.); and Department of Cardiology, Renmin Hospital of Wuhan University, Wuhan, China ... Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China; National Clinical Research Center for Kidney Disease, Guangzhou, China; State Key Laboratory of Organ Failure Research, Guangzhou, China; Guangdong Provincial Institute of Nephrology, Guangzhou, China From the Departments of Surgery (T.W.H., Y.R., L.K.) and Medical Physiology (E.Q., X.X., N.T., L.K.), College of Medicine, Texas A&M Health Science Center, Scott & White Healthcare, Temple; and Department of Companion Animal Clinical Sciences, Faculty of Veterinary Medicine, Kasetsart University, Bangkok, Thailand (N.T.). Mikrobiologisches Institut, Universitätsklinikum Erlangen, Erlangen, Germany School of Kinesiology, Shanghai University of Sport, Shanghai, China.; Department of Exercise Rehabilitation, Shanghai University of Sport, Shanghai, China. Department of Neurosurgery The First Medical Center of Chinese PLA General Hospital Beijing China Department of Medicine University of Alabama at Birmingham Birmingham Alabama USA; Program in Protease and Matrix Biology University of Alabama at Birmingham Birmingham Alabama USA Chemical Sciences, Inflammation, and Drug Safety and Metabolism, Wyeth Research, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140 Memory, Ageing and Cognition Centre (MACC), Department of Pharmacology, Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore; School of Public Health and the 2nd Affiliated Hospital of School of Medicine Zhejiang University Hangzhou China Departments of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China; National Clinical Research Center for Interventional Medicine, Shanghai, China; Institute of Vascular Surgery, Fudan University, Shanghai, China Siyuan Laboratory Guangdong Provincial Engineering Technology Research Center of Vacuum Coating Technologies and New Energy Materials Department of Physics Jinan University Guangzhou Guangdong 510632 P. R. China Department of Aviation Oil, Air Force Logistics College, Xuzhou 221000, Jiangsu, China; State Key Laboratory of Tribology, Tsinghua University, Beijing 100084, China Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts (J.F.W., C.Y.L., F.Z., M.C., X.X., J.W., S.S., D.R.) From the Cardiovascular Division and Lillehei Heart Institute, Department of Medicine, University of Minnesota Medical School, Minneapolis (H.W., D.K., J.F., X.X., A.C., J.L.H., R.J.B., Y.C.); Department of Cardiology, Shanghai Tenth People’s Hospital of Tongji University, Shanghai, China (L.H., Y.X., J.-b.G.); and Division of Blood and Marrow Transplantation, Department of Pediatrics, Masonic Cancer Center, University of Minnesota, Minneapolis (W.C., B.R.B.). Organisch-Chemisches Institut, Universität Münster, Corrensstrasse 40, D-48149 Münster, Germany CAS Key Laboratory of Bio-Based Materials; Qingdao Institute of Bioenergy and Bioprocess Technology; Chinese Academy of Sciences; Qingdao, China National Center of Biomedical Analysis, Beijing, China; Nanhu Laboratory, Jiaxing, China Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, USA Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China; Graduate School of Peking Union Medical College, Beijing 100730, China 1Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China; 2School of Pharmacy, University of Chinese Academy of Sciences, Beijing, China Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China; and Department of Urology, The First Affiliated Hospital School of Medicine Zhejiang University, Hangzhou, China. School of Chemical Engineering, The University of Adelaide, Adelaide, SA 5005, Australia National Center for Advancing Translational Science, National Institutes of Health, Rockville, Maryland 20892, United States General Surgery Department, The First Affiliated Hospital of Anhui Medical University, Hefei 230000, China Department of Neurobiology, Civitan International Research Center University of Alabama at Birmingham Birmingham AL 35294 USA Department of Cardiothoracic Surgery, the First Affiliated Hospital of Guangzhou Medical College, Guangzhou 510120, China; ; Guangzhou Institute of Respiratory Disease, China State Key Laboratory of Respiratory Disease, Guangzhou 510520, China; ; Guangdong Cardiovascular Institute, Guangzhou 510080, China. Xiamen University 1 State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, , Xiamen 361005, China; Fudan University 3 Department of Chemistry, MOE Laboratory for Computational Physical Science, , Shanghai 200433, China Laboratory for Stem Cell and Regenerative Medicine, School of Life Science and Technology, Weifang Medical University, Weifang, China Beijing Key Laboratory of Applied Experimental Psychology, Faculty of Psychology, Beijing Normal University, Beijing, People’s Republic of China Department of Neurology, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400016, China. School of Biomedical Engineering, Science and Health Systems, Drexel University 1 , Philadelphia, Pennsylvania 19104, USA High-End Chemicals and Cutting-Edge New Materials Technology Innovation Center of Hefei, East China Engineering Science and Technology Co., LTD., Hefei 230088, P. R. China National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Renal Division, Nanfang Hospital Southern Medical University Chemical and Screening Sciences, and Cardiovascular and Metabolic Diseases, Wyeth Research, 200 Cambridge Park Drive, Cambridge, Massachusetts 02140, Chemical and Screening Sciences, Wyeth Research, 401 Middletown Road, Pearl River, New York 10965, Discovery PK, Wyeth Research, One Burtt Rd, Andover, Massachusetts 01810, and Biotransformation, Wyeth Research, 500 Arcola Road, Collegeville, Pennsylvania 19426 National Clinical Research Center for Kidney Disease, Nanfang Hospital, Guangzhou, China Shanghai Key Lab of Chemical Assessment and Sustainability School of Chemical Science and Engineering Tongji University Siping Road 1239 Shanghai 200092 China Department of Vascular Surgery, Institute of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine, and; Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, Alabama Beijing Key Laboratory of Applied Experimental Psychology, National Demonstration Center for Experimental Psychology Education (Beijing Normal University), Faculty of Psychology, Beijing Normal University, China From the Cardiovascular Division (P.Z., X.H., X.X., J.F., G.Z., R.J.B., Y.C.) and Center for Vascular Biology (X.H., X.X., G.Z., Y.C.), Department of Medicine, Supercomputing Institute (W.X.), and Department of Biochemistry, Molecular Biology, and Biophysics (B.W., D.A.B.), University of Minnesota, Minneapolis; and the Institut Cochin (B.V.), Université René Descartes, Centre National de la Recherche Scientifique (UMR 8104), Paris, France; and Institut National de la Santé et de la Recherche... From the Departments of Neonatology (M.L.H., G.H.H., M.I.S.R., G.G.) and Intensive Care (S.H.-S.), Copenhagen Trial Unit, Center for Clinical Intervention Research, the Capital Region (M.H.O., C.G., J.C.J.), and the Department of Neuroanesthesiology, Neuroscience Center (M.H.O.), Copenhagen University Hospital–Rigshospitalet, and the Section of Biostatistics, Department of Public Health, University of Copenhagen (A.K.G.J.), Copenhagen, the Neonatal Intensive Care Unit, Aarhus University Hospital,... State Key Laboratory of Physical Chemistry of Solid Surfaces and Department of Chemistry, Xiamen University, Xiamen 361005, China Xiamen University State Key Laboratory for Physical Chemistry of Solid Surfaces and Center for Theoretical Chemistry, Institute of Physical Chemistry, Department of Chemistry, , Xiamen, 361005, People’s Republic of China School of Stomatology, Shandong University, Jinan, Shandong 250012, P.R. China Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing China Department of Oral and Maxillofacial Surgery, Zhejiang University, Hangzhou, China. [email protected] Department of Hematology, Jiangyin People's Hospital, Jiangyin, Jiangsu 214400, P.R. China College of Computer Science and Technology, Shenyang University of Chemical Technology, Shenyang 110000, China Department of Neurosurgery Xuanwu Hospital, Capital Medical University Beijing China Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, Suzhou 215123, China Institute for Tropical Medicine, Kunming Medical University School of Basic Medical Sciences, Kunming, China; Yunnan Province Key Laboratory for Tropical Infectious Diseases in Universities, Kunming Medical University, Kunming, China School of Artificial Intelligence, Beijing Technology and Business University, Beijing 100048, China; State Environmental Protection Key Laboratory of Food Chain Pollution Control, Beijing Technology and Business University, Beijing 100048, China School of Aeronautics Northwestern Polytechnical University Xi'an Shaanxi PR China Therapeutic Development Branch, National Center for Advancing Translational Sciences, National Institutes of Health Rockville MD USA Medical Psychological InstituteThe Second Xiangya Hospital of Central South University, Changsha P.R. China Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis, MN, USA MOE Key Laboratory for Analytical Science of Food Safety and Biology; Fujian Provincial Key Laboratory of Analysis and Detection Technology for Food Safety, College of Chemistry, Fuzhou University, Fuzhou, Fujian, 350116, P. R. China MOE Key Laboratory for Analytical Science of Food Safety and Biology; Fujian College of Chemistry; Fuzhou University; Fuzhou 350116; P. R. China Department of Dentistry, Affiliated Hospital, Weifang Medical University, Weifang 261000, Shandong, China. Jinan Central Hospital Affiliated to Shandong University Jinan China Department of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Research Center of Dental Materials and Oral Tissue Regeneration & Shandong Provincial Clinical Research Center for Oral Diseases, Jinan, China State Key Laboratory and Institute of Elemento-organic Chemistry, Collaborative Innovation Center of Chemical Science and Engineering (Tianjin), Nankai University, Tianjin 300071, China National Laboratory of Solid‐State Microstructures, School of Electronic Science and Engineering, Collaborative Innovation Center of Advanced Microstructures Nanjing University Nanjing 210093 P. R. China Key Laboratory of Systems Biomedicine of Ministry of Education, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University (SJTU) and State Key Laboratory of Medical Genomics, Shanghai Institute of Hematology, Rui Jin Hospital, SJTU School of Medicine, Shanghai, China; College of Horticulture and Plant Protection Yangzhou University Yangzhou China Contribution from the NUS Nanoscience & Nanotechnology Initiative, National University of Singapore, 2 Science Drive 3, Singapore, 117542, Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore, 117542, and Temasek Laboratories, National University of Singapore, Engineering Drive 2, Singapore, 119260 Key Laboratory for Renewable Energy; Chinese Academy of Sciences; Beijing Key Laboratory for New Energy Materials and Devices; Institute of Physics; Chinese Academy of Sciences From the Department of Systems Biology and Translational Medicine (N.T., T.W.H., W.W., X.X., Z.L., L.K.), Cardiovascular Research Institute, College of Medicine, Texas A&M University System Health Science Center, Temple, Tex; Department of Small Animal Medicine and Surgery (T.W.F.), College of Veterinary Medicine, Texas A&M University, College Station, Tex. Current Address for Naris Thengchaisri: Faculty of Veterinary Medicine, Kasetsart University, 50 Paholyothin Road, Bangkhen, Bangkok,... Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140 Department of Medicine, University of Auckland, Private Bag 92019, Auckland, New Zealand Department of Clinical Epidemiology Shengjing Hospital of China Medical University Shenyang China 1Department of Oncology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, People's Republic of China. Departments of Chemical and Screening Sciences, Inflammation, Drug Safety and Metabolism, and Chemical and Pharmaceutical Development, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140, and Mount Sinai Medical Center, 4300 Alton Road, Miami Beach, Florida 33140 Liver Cancer Institute and Zhongshan Hospital of Fudan University Shanghai China Departmentof Public Health Laboratory Sciences West China School of Public Health, Sichuan University Chengdu Sichuan China Division of Pulmonary, Allergy and Critical Care Medicine, University of Alabama at Birmingham, Birmingham, Alabama; Program in Protease and Matrix Biology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama; Gregory Fleming James Cystic Fibrosis Research Center, University of Alabama at Birmingham, Birmingham, Alabama; Lung Health Center, University of Alabama at Birmingham, Birmingham, Alabama; Medical Service at Birmingham Veterans Affairs Medical Center, Birmingham, Alabama School of Stomatology, Shandong University, Jinan, P.R. China.; Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, P.R. China. Department of Electronic Engineering, The Chinese University of Hong Kong, Shatin, New Territories, Hong Kong SAR, P. R. China Department of Dental Implantology School of Stomatology, Shandong University, Shandong Province Jinan 250012 People's Republic of China; Key Lab of Oral Biomedicine of Shandong Province Jinan 250012 People's Republic of China Department of Pharmacology, National University of Singapore, Singapore; Memory Aging and Cognition Center, National University Health System, Singapore Key Laboratory of Inorganic Chemistry in Universities of Shandong, Department of Chemistry and Chemical Engineering, Jining University, Qufu, Shandong 273155, P. R. China Department of Aviation Oil and Material, Air Force Logistic College, Xuzhou 221000, China Zhejiang University School of Public Health, Hangzhou, China; Zhejiang University School of Medicine Second Affiliated Hospital, Hangzhou, China; The Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province, Hangzhou, China Department of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University & Shandong Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, Shandong, People’s Republic of China Department of Oral and Maxillofacial Surgery,Second Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310009,China. Key Laboratory of Plant Hormones and Development Regulation of Chongqing School of Life Sciences Chongqing University Chongqing China; Center of Plant Functional Genomics Institute of Advanced Interdisciplinary Studies Chongqing University Chongqing China State Key Laboratory of Reproductive Medicine Nanjing Medical University Nanjing China; Department of Epidemiology, Center for Global Health, School of Public Health Nanjing Medical University Nanjing China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine Nanjing Medical University Nanjing China College of Life Sciences, Capital Normal University, Beijing, China; Department of Microbiology and Immunology, University of Saskatchewan, Saskatoon, Saskatchewan, Canada Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, P.R. China State Key Laboratory for Mechanical Behavior of Materials and MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter; Department of Applied Chemistry; School of Science; Xi'an Jiaotong University; Xi'an 710049, China Institute of Mass Spectrometry and Atmospheric Environment, Jinan University, Guangzhou 510632, China; Guangdong Provincial Engineering Research Center for On-line Source Apportionment System of Air Pollution, Guangzhou, 510632, China; Guangdong-Hongkong-Macau Joint Laboratory of Collaborative Innovation for Environmental Quality, Guangzhou 511443, China Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China From the Department of Molecular Medicine, Osaka University Graduate School of Medicine, Osaka, Japan School of Exercise and Health, Shanghai University of Sport, Shanghai 200438, China State Key Laboratory of Molecular Oncology, Cancer Hospital/Institute, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China Laboratory for Stem Cell and Regenerative Medicine The Affiliated Hospital of Weifang Medical University Weifang China; College of Bioscience and Technology Weifang Medical University Shandong China Key Laboratory for Renewable Energy (CAS), Beijing Key Laboratory for New Energy Materials and Devices, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, China; School of Physical Sciences, University of Chinese Academy of Sciences, Beijing 100049, China UIC Institute for Health Research and Policy, Westside Research Office, Chicago, Illinois Department of General Surgery, Jiangning Hospital, Nanjing, Jiangsu Key Laboratory of Plant Hormones and Development Regulation of Chongqing School of Life Sciences Chongqing University Chongqing China Siyuan Laboratory; Guangzhou Key Laboratory of Vacuum Coating Technologies and New Energy Materials; Guangdong Provincial Engineering Technology Research Center of Vacuum Coating Technologies and New Energy Materials; Department of Physics; Jinan University College of Bioresources Chemical and Materials Engineering, National Demonstration Center for Experimental Light Chemistry Engineering Education, Shaanxi Province Key Laboratory of Papermaking Technology and Specialty Paper, Key Laboratory of Functional Printing and Transport Packaging of China National Light Industry, Key Laboratory of Paper Based Functional Materials of China National Light Industry, Shaanxi University of Science & Technology, Xi'an 710021, China Department of Epidemiology, Center for Global Health School of Public Health, Nanjing Medical University Nanjing Jiangsu Province China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Collaborative Innovation Center for Cancer Medicine Nanjing Medical University Nanjing Jiangsu Province China Department of Transplantation, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou, China Departments of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409-1061 and Brigham Young University, Provo, Utah 84602-5700 1State Key Laboratory of Molecular Oncology and School of Life Science, Peking University, Beijing 100871,China Siyuan Laboratory, Guangzhou Key Laboratory of Vacuum Coating Technologies and New Energy Materials, Guangdong Provincial Engineering Technology Research Center of Vacuum Coating Technologies and New Energy Materials, Department of Physics, Jinan University, Guangzhou 510632, China Collaborative Innovation Center of Chemistry for Energy Materials; Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials; MOE Laboratory for Computational Physical Science; Department of Chemistry; Fudan University Department of Public Health Laboratory Sciences West China School of Public Health (No. 4 West China Teaching Hospital) Sichuan University Chengdu China School of Stomatology, Shandong University, Jinan, Shandong, China (mainland) Authors' Affiliations: 1State Key Laboratory of Molecular Oncology and 2Department of Pathology, Cancer Institute (Hospital), Peking Union Medical College & Chinese Academy of Medical Sciences, Beijing, China HeBei General Hospital, Hebei, China School of Public Health, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China Institute of Unmanned Systems, College of Mechatronics and Automation, National University of Defense Technology, Changsha, China State Key Laboratory for Physical Chemistry of Solid Surfaces; Department of Chemistry, Center for Theoretical Chemistry, Xiamen University, Xiamen 361005, China School of Public Health, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China State Key Laboratory of Physical Chemistry of Solid Surfaces; College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China Suzhou Institute of Systems Medicine Center for Systems Medicine, Chinese Academy of Medical Sciences Suzhou Jiangsu China Department of Chemistry, Xiamen University, Xiamen, P. R. China, and Department of Chemistry and Theoretical Chemistry Institute, University of Wisconsin, Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States State Key Laboratory of Environmental Geochemistry Institute of Geochemistry Chinese Academy of Sciences Guiyang China Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy, Xuzhou Medical University, Tongshan Road 209, Xuzhou 221004, China National Center for Advancing Translational Sciences, National Institutes of Health, 9800 Medical Center Drive, Rockville, Maryland 20850, United States for the 23andMe Research Team, China Kadoorie Biobank Collaborative Group, and Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium 1State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China.; 2Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, P.R. China. Collaborative Innovation Center of Chemistry for Energy Materials, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, MOE Laboratory for Computational Physical Science, Department of Chemistry, Fudan University Shanghai 200433 China College of Light Industry Science and Engineering, Tianjin University of Science and Technology, Tianjin 300457, P.R. China Collaborative Innovation Center of Chemistry for Energy Materials, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Ministry of Education Key Laboratory of Computational Physical Sciences, Department of Chemistry, Fudan University, Shanghai, 200433, China Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province, People’s Republic of China State Key Laboratory of Oral Diseases, West China School of Stomatology, Sichuan University, Chengdu, Sichuan, China Key Laboratory of Animal Molecular Nutrition of Education of Ministry; College of Animal Sciences; Zhejiang University; Hangzhou 310058 China Xiamen University State Key Laboratory of Physical Chemistry of Solid Surfaces and Center for Theoretical Chemistry, College of Chemistry and Chemical Engineering, , Xiamen 361005, China National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, China Beijing From the Lillehei Heart Institute and the Cardiovascular Division (Y.C., H.G., D.X., X.X., H.W., X.H., Z.L., D.K., Y.H.), University of Minnesota Medical School, Minneapolis, MN; Key Laboratory of Cardiovascular Remodeling and Function Research (H.G.), Chinese Ministry of Education and Chinese Ministry of Health, Qilu Hospital, Shandong University, Shandong, China; Department of Cardiology (D.X., Y.X.), Shanghai Tenth People's Hospital of Tongji University, Shanghai, China; Research Animal Resources... Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, P. R. China Department of Neurology, Chongqing Key Laboratory of Neurology, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China National Clinical Research Center for Kidney Disease, State Key Laboratory for Organ Failure Research, Renal Division, Nanfang Hospital, Southern Medical University, Guangzhou, China Department of Cardiology, Nanjing Medical University Affiliated Wuxi Second Hospital Department of Cardiovasology Yue Bei People's Hospital Huimin South Road Shaoguan 512026 Guangdong Province China State Key Laboratory Breeding Base of Green-Chemical Synthesis Technology College of Chemical Engineering Zhejiang University of Technology Chaowang Rd. 18 Hangzhou 310014 P. R. China Department of Epidemiology, Center for Global Health School of Public Health, Nanjing Medical University Nanjing China; Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University Nanjing China Chinese Academy of Sciences 1 State Key Laboratory of Molecular Reaction Dynamics and Center for Theoretical Computational Chemistry, Dalian Institute of Chemical Physics, , Dalian 116023, People's Republic of China Harvard Medical School and Harvard Pilgrim Healthcare Institute, Boston, MA Laboratory of Developmental Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Department of Health and Human Services, Bethesda, Maryland 20892; School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia; College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, China State Key Laboratory of Proteomics National Center of Biomedical Analysis Beijing China Henan Province Key Laboratory of Targeting Therapy and Diagnosis for Critical Diseases; School of Pharmaceutical Sciences, Zhengzhou University; Zhengzhou; China; Key Laboratory of Key Technology of Drug Preparation School of Life Sciences, Anhui Agricultural University Hefei China; Anhui International Joint Research and Developmental Center of Sericulture Resources Utilization Hefei China Department of Radiation Oncology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, P.R. China Chongqing University Key Laboratory of Plant Hormones and Development Regulation of Chongqing, School of Life Sciences, , Chongqing 400044, China; Institute of Advanced Interdisciplinary Studies Center of Plant Functional Genomics, , Chongqing University, 401331 Chongqing, China Department of Urology, China-Japan Friendship Hospital, Chaoyang District Department of Cardiology, Liaocheng Third People’s Hospital, Liaocheng 252000, Shandong Province, China Department of Hepatobiliary Surgery, The Affiliated Hospital of Hangzhou Normal University, Hangzhou, Zhejiang 310011, P.R. China Department of Urology, First Affiliated Hospital, Zhejiang University, Hangzhou, Zhejiang Province, China Department of Public Health Laboratory Sciences West China School of Public Health Sichuan University Chengdu China Interdisciplinary Microsystems Group, Department of Mechanical and Aerospace Engineering, University of Florida, P.O. Box 116250, Gainesville, Florida 32611, United States Texas Children's Cancer Center, Center for Cell & Gene Therapy, Baylor College of Medicine, Houston, Texas, USA YMU-HKBU Joint Laboratory of Traditional Natural Medicine; Yunnan Minzu University; Kunming; China Department of Neurosurgery, Tianjin Medical University General Hospital, Tianjin;; Key Laboratory of Post-Neuroinjury Neuro-repair and Regeneration in the Central Nervous System, Ministry of Education, Tianjin Medical University, Tianjin Key Laboratory of Injury and Regenerative Medicine of Nervous System, Tianjin Neurological Institute, Tianjin, China; Department of Information Center, Beijing Children's Hospital, Capital Medical University, National Center for Children's Health. Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-psycho-diseases, Department of Pharmacology, College of Pharmaceutical Sciences, and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Soochow University, Suzhou 215123, P. R. China Department of Oral Medicine, Heilongjiang Nursing College, Harbin, China College of Biotechnology, Center for Self-Propelled Nanotechnologies, Suzhou Industrial Park Institute of Services Outsourcing, Suzhou, P. R. China; Translational Cancer Research Laboratory, Suzhou Acumen Medical Technology, Suzhou, P. R. China Division of Magnetic Resonance, Department of Radiology, Johns Hopkins University School of Medicine , Baltimore, MD 21287 , USA Department of Emergency, Hebei General Hospital, Shijiazhuang 050051, Hebei Province, P.R. China Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang CAS Key Laboratory of Biobased Materials, Qingdao Institute of Bioenergy and Bioprocess Technology, Chinese Academy of Sciences, Qingdao, China; University of Chinese Academy of Sciences, Beijing, China Department of Chemistry, Fudan University, Shanghai, 200433, P. R. China. Shanghai University of Sport Shanghai China Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, People Republic of China College of Life Sciences, Hubei University, Wuhan 430062, Hubei, China School of Chemistry and Chemical Engineering Huazhong University of Science and Technology 430074 Wuhan Hubei P. R. China 1Department of Biochemistry and National Institute of Natural Hazards, Beijing 100085, China; School of Emergency Management Science and Engineering, University of Chinese Academy of Sciences, Beijing 100049, China National Engineering Research Center for the Emergency Drug, Beijing Institute of Pharmacology and Toxicology, Beijing, China General Surgery Department, the First Affiliated Hospital of Anhui Medical University, Hefei, China Nanfang Hospital Southern Medical University Guangzhou China Authors' Affiliations: 1Center for Genetics and Molecular Medicine, Department of Biochemistry and Molecular Biology; and 2James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Science and Peking Union Medical College, Beijing 100021, China School of Public Health & the 2nd Affiliated Hospital of School of Medicine, Zhejiang University, China; Memory, Ageing and Cognition Centre (MACC), Department of Pharmacology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore The State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu China Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Soochow University, Suzhou 215123, P. R. China NHLBI, NIH, Bethesda, Maryland, United States Department of Exercise Rehabilitation, Shanghai University of Sport, Shanghai, China.; Shanghai Anti-doping Laboratory, Shanghai University of Sport, Shanghai, China. Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin Medical University, Tianjin 300070, China College of Materials Science and Engineering, Nanjing Tech University, Nanjing 210009, China School of Life Science, Shanxi University, Taiyuan 030006, China; Shanxi Key Laboratory for Research and Development of Regional Plants, Shanxi University, Taiyuan 030006, China Key Laboratory of Plant Hormones and Development Regulation of Chongqing, School of Life Sciences Chongqing University Chongqing 400044 China The Institute for Tropical Medicine, Kunming Medical University, Kunming, China Mental Health Center, West China Hospital of Sichuan University, Chengdu, Sichuan, PR China Department of Orthopedics, China-Japan Friendship Hospital, Graduate School of Peking Union Medical College, Chinese Academy of Medical Sciences, Beijing, 100029, P. R. China. 1Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China; 2University of Chinese Academy of Sciences, Beijing, China Department of Chemistry, University of Massachusetts Lowell, Lowell, MA 01854, USA. Department of Biochemistry and Molecular Biology, Key Laboratory of Immune Microenvironment and Disease (Ministry of Education), Tianjin Medical University, Tianjin, China Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangzhou, China Department of Science and Technology of Anhui Province, School of Life Sciences Anhui Agricultural University Hefei China; National Fund Committee of China Anhui International Joint Research and Developmental Center of Sericulture Resources Utilization Hefei China Departments of Chemical and Screening Sciences, Inflammation, and Drug Safety and Metabolism, Wyeth Research, 200 CambridgePark Drive, Cambridge, Massachusetts 02140 Department of Critical Care Medicine, Zhongshan Hospital, Fudan University , Shanghai, China; Department of Critical Care Medicine, Pan Long People’s Hospital , Kunming, China Reproductive Medical Center, The Second Hospital of Jilin University, Changchun, People's Republic of China. Centre for Behavioural Ecology and Evolution (CBEE), College of Life Sciences, Hubei University, Wuhan, People's Republic of China College of Pharmaceutical Science Zhejiang University of Technology Hangzhou China Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, Atlanta, GA Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine; Program in Protease and Matrix Biology From the International Peace Maternity and Child Health Hospital (B.H., X.Y., Y.L., D.H., W.Y., H.Z., W.C.), Institute of Embryo-Fetal Original Adult Disease (X.Y.), and Department of Obstetrics and Gynecology, Xinhua Hospital (X.X.), School of Medicine, Shanghai Jiao Tong University, China; State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Science (Y.D., Z.C.); and School of Life Science and... College of Food Science and Engineering Yangzhou University Yangzhou China Key Laboratory of Animal Molecular Nutrition of Education of Ministry, College of Animal Sciences, Zhejiang University, 866 Yu Hang Tang Road, Hangzhou, Zhejiang 310058, China Collaborative Innovation Center of Chemistry for Energy Materials, Key Laboratory of Molecular Catalysis and Innovative Materials, MOE Key Laboratory of Computational Physical Sciences, Department of Chemistry, Fudan University, Shanghai 200433, China Henan Key Laboratory of Polyoxometalate Chemistry; College of Chemistry and Chemical Engineering; Henan University; Kaifeng; China Department of Pharmacology, National University of Singapore, Singapore; Memory Aging and Cognition Centre, National University Health System, Singapore; Centre for Population Health Sciences, Nanyang Technological University, Singapore Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai, China; Institute of Vascular Surgery, Fudan University, Shanghai, China Yue Bei People's Hospital Shaoguan, Guangdong Province China Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices, Institute of Functional Nano and Soft Materials (FUNSOM), Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, Zhejiang, PR China Department of Clinical Epidemiology From the Center for Vascular Biology (Z.L., X.X., X.H., G.Z., Y.C.) and Cardiovascular Division, Department of Medicine (J. Fassett, X.H., G.Z., J. French, P.Z., R.J.B., Y.C.), University of Minnesota, Minneapolis; and National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Md (J.S.). Wellcome Trust and Cancer Research UK Gurdon Institute & Department of Zoology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QN,UK. Department of Biochemistry, Department of Chemistry, State Key Laboratory of Physical Chemistry of Solid Surfaces, Center for Theoretical Chemistry, College for Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China; and Department of Chemistry, Xiamen University, Xiamen 361005, China School of Stomatology, Shandong University, Jinan, China; Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Jinan, China Anesthesiology Department, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, People's Republic of China 210008. Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, MOE Laboratory for Computational Physical Science, Department of Chemistry, Fudan University, Shanghai 200433, People’s Republic of China Drug Metabolism and Pharmacokinetics, Division of Preclinical Innovation (DPI), National Center for Advancing Translational Sciences (NCATS), National Institutes of Health, Rockville, MD, USA MOA Key Laboratory of Soybean Biology (Beijing) Institute of Crop Science The Chinese Academy of Agricultural Sciences 12 Zhongguancun South Street Beijing 100081 China College of Food Science and Engineering, Hanjiang District, Yangzhou University, 196 Huayang Western Road, Yangzhou 225127, China State Key Laboratory of Molecular Reaction Dynamics and Center for Theoretical Computational Chemistry, Dalian Institute of Chemical Physics, Chinese Academy of Sciences; Dalian 116023; China Department of Molecular and Cellular Biology, University of Guelph, Guelph, ON Canada Department of Human and Molecular GeneticsHerbert Wertheim College of Medicine, Florida International UniversityMiamiFloridaUSA The Liver Cancer Institute Zhongshan Hospital and Shanghai Medical School Fudan University Shanghai P.R. China; Key Laboratory for Carcinogenesis and Cancer Invasion The Chinese Ministry of Education Shanghai P.R. China Department of Obstetrics and Gynecology, Peking University Third Hospital, Beijing, 100191, P.R. China Department of Implantology, Shandong Provincial Key Laboratory of Oral Biomedicine , Shandong University School of Stomatology , Wenhua West Road No.44-1, Jinan250012 , Shandong Province , People’s Republic of China State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, Beijing 100083, China. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China Departments of 1Chemistry and Division of Nephrology, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China Department of Shanghai Institute of Thoracic Oncology; Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China. Department of Clinical Pharmacy Hubei No. 3 People's Hospital of Jianghan University Wuhan China Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, Ministry of Education (MOE) Laboratory for Computational Physical Science, Department of Chemistry, Fudan University Shanghai 200433 People's Republic of China Newcastle Biobank, Faculty of Medical Sciences Newcastle University Newcastle‐upon‐Tyne UK College of Food Science and Engineering, Yangzhou University, Yang Zhou, China Department of Mechanical & Aerospace Engineering University of Florida Gainesville FL USA Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang Province, P.R. China Department of Epidemiology, China International Cooperation Center on Environment and Human Health, Center for Global Health, School of Public Health Nanjing Medical University Nanjing China Department of Psychology, School of Social and Behavioral Sciences, Nanjing University, China Program of Population Genetics, Harvard School of Public Health, Boston, Massachusetts 02115 *Department of Immunology and Host Defenses, Ehime University School of Medicine, Shigenobu, Ehime, Japan; and Department of Exercise Rehabilitation, Shanghai University of Sport School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan, Hubei430074, China Medical Psychological Institute Second Xiangya Hospital of Central South University Changsha China BioTherapeutics Chemistry, Pfizer Worldwide Medicinal Chemistry, 200 Cambridgepark Drive, Cambridge, Massachusetts 02140, United States From the Department of Molecular Medicine, Osaka University Graduate School Medicine (M.O., H.S., X.X., S.S., H.K., S.K.), and Osaka University (T.K.), Suita-City, Osaka, Japan. School of Kinesiology, Shanghai University of Sport, Shanghai, China School of Materials Science and Engineering, Nanyang Technological University, Singapore 639798, Singapore Department 1 of Traditional Chinese Medicine Cangzhou Central Hospital Cangzhou Hebei China State Key Laboratory of Physical Chemistry of Solid Surfaces, Center for Theoretical Chemistry, College for Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China, and Department of Chemistry, Hong Kong University of Science and Technology, Kowloon, Hong Kong Key Laboratory for Nuclear-Agricultural Sciences of Chinese Ministry of Agriculture and Zhejiang Province, Institute of Nuclear-Agricultural Sciences, Zhejiang University, 310029 Hangzhou, PR China Department of Mechanical Engineering University of Colorado Boulder CO 80309 USA Department of Aviation Oil and Material, Air Force Logistics College, Xuzhou 221000, China Department of Hematology & Oncology, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, China; Immunology Institute, Mount Sinai School of Medicine, New York, NY, USA Memory Ageing and Cognition Centre (MACC), National University Health System, Singapore, Singapore; Department of Pharmacology, National University of Singapore, Singapore, Singapore Department of Pharmacology, National University of Singapore, Singapore; Memory Aging and Cognition Centre, National University Health System, Singapore Laboratory of Materials for Energy Conversion; Department of Materials Science and Engineering; University of Science and Technology of China; Hefei; P. R. China State Key Laboratory of Molecular Oncology, Cancer Institute (Hospital), Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China Department of Vascular and Endocrine Surgery, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China Department of Medical Physiology, College of Medicine, Texas A&M Health Science Center, Temple, Texas, United States Department of Chemistry and Biochemistry, Texas Tech University, Lubbock, Texas 79409-1061, and Department of Chemistry and Biochemistry, Brigham Young University, Provo, Utah 84602-5700 From the Center of Vascular Biology and Cardiovascular Division, Department of Medicine, University of Minnesota Medical School, Minneapolis. Key Laboratory of Photochemical Conversion and Optoelectronic Materials, New Cornerstone Science Laboratory, Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Beijing 100190, P. R. China; School of Future Technology, University of Chinese Academy of Sciences, Beijing 100049, P. R. China State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China Department of Obstetrics and Gynecology, Hubei Provincial Hospital of TCM, Wuhan 430065, Hubei, China Department of Psychology, School of Education, Soochow University, Suzhou, People’s Republic of China Shaanxi Institute of Flexible Electronics (SIFE) Northwestern Polytechnical University (NPU) Xi'an 710072 China; Division of Physics and Applied Physics School of Physical and Mathematical Sciences Nanyang Technological University Singapore 637371 Singapore State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, Liaoning, 116023, P. R. China. Division of Health Policy and Insurance Research, Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts Weldon School of Biomedical Engineering, Purdue University, West Lafayette, Indiana.; Department of Mechanical Engineering, University of Colorado Boulder, Boulder, Colorado. Department of General Surgery, Jinling Hospital, Nanjing, Jiangsu, China (mainland) Liuyang CDC, Changsha, China. Hubei Key Laboratory of Animal Nutrition and Feed Science, Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Wuhan Polytechnic University, PR China Peking-Tsinghua Center for Life Sciences, Peking University, Beijing 100871, China;; National Laboratory of Protein and Plant Gene Research, College of Life Sciences, Peking University, Beijing 100871, China; Beijing Institute of Technology; Beijing Institute of Technology Chongqing Innovation Center State Key Laboratory of Organ Failure Research Renal Division National Clinical Research Center for Kidney Disease Guangdong Provincial Institute of Nephrology Nanfang Hospital Southern Medical University Guangzhou China State Key Laboratory of Molecular Reaction Dynamics; Dalian Institute of Chemical Physics; Chinese Academy of Sciences; Dalian 116023; P. R. China Department of General Surgery, Second Affiliated Hospital of Xi'an Jiaotong University, Xi'an, Shaanxi 710004, P.R. China Department of Clinical Epidemiology, Shengjing Hospital of China Medical University , Shenyang, China Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, China. State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences 1 , Dalian, Liaoning 116023, China; University of Chinese Academy of Sciences 2 , Beijing 100049, China Materials and Process Simulation Center, Beckman Institute (MC 139-74), California Institute of Technology, Pasadena, CA 91125 USA College of Food Science and Engineering, Yangzhou University, 225127 Yangzhou, Jiangsu Province, China Newcastle Fibrosis Research Group, Institute of Cellular Medicine, Faculty of Medical Sciences,Newcastle University,Newcastle upon Tyne,United Kingdom Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, St Lucia, Queensland 4072, Australia; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of Queensland, St Lucia, Queensland 4072, Australia College of Medical Laboratory Dalian Medical University Dalian Liaoning Province China National Center for Advancing Translational Sciences, National Institutes of Health, Bethesda, Maryland, USA MOE Laboratory for Computational Physical Science, Department of Chemistry, Fudan University 3 , Shanghai 200433, China School of Chemistry and Chemical Engineering and Hubei Key Laboratory of Bioinorganic Chemistry and Materia Medica, Huazhong University of Science and Technology, 1037 Luoyu Road, Wuhan, Hubei 430074, P. R. China National Laboratory of Solid-State Microstructures, School of Electronic Science and Engineering, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing, Jiangsu 210093, P. R. China National Clinical Research Center for Kidney Disease, Nanfang Hospital, Southern Medical University, Guangzhou, China2State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China3Guangdong Provincial Institute of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China4Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China Department of Radiation Oncology, Renji Hospital, School of Medicine, Shanghai Jiaotong University, Shanghai, People’s Republic of China Office on Smoking and Health, Centers for Disease Control and Prevention, Atlanta, GA, USA Nanfang Hospital, Southern Medical University; National Clinical Research Center for Kidney Disease; State Key Laboratory of Organ Failure Research, Guangzhou 510515, China Division of Pulmonary, Allergy and Critical Care Medicine, Program in Protease and Matrix Biology, Gregory Fleming James Cystic Fibrosis Centre and Lung Health Center, University of Alabama at Birmingham, Birmingham, AL 35294, USA.; Birmingham VA Medical Center, Birmingham, AL 35233, USA. Department of Neurology, Daqing Oilfield General Hospital , Daqing 163001 , China Department of General Surgery Shanghai Ninth People’s Hospital Shanghai JiaoTong University School of Medicine China Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Department of Gastrointestinal Hepatobiliary Surgery, The Affiliated Hospital of Hangzhou Normal University, Gongshu, Hangzhou 310015, China Department of Chemistry, Zhejiang Sci-Tech University, Hangzhou, Zhejiang 310018, PR China School of Physical Science and Technology and Key Laboratory of Artificial Micro‐ and Nano‐Structures of Ministry of Education Wuhan University Wuhan 430072 P. R. China; State Key Lab of Optoelectronic Materials and Technologies Guangdong Province Key Laboratory of Display Material and Technology School of Electronics and Information Technology Sun Yat‐sen University Guangzhou 510275 P. R. China Siyuan Laboratory, Department of Physics, Jinan University, Guangzhou 510632, China Department of General ICU The Second Affiliated Hospital of Zhejiang University School of Medicine Hangzhou Zhejiang China Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China State Key Laboratory of Molecular Oncology, National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College Beijing, China. Department of Urology Peking University First Hospital Beijing China School of Physical Science and Technology, Southwest Jiaotong University, Chengdu, Sichuan 610031, People’s Republic of China College of Life Sciences, Hunan Normal University, Changsha, Hunan 410081, China; State Key Laboratory of Biocatalysis and Enzyme Engineering, and Centre for Behavioural Ecology and Evolution, School of Life Sciences, Hubei University, 368 Youyi Road, Wuhan 430062, Hubei Province, China; School of Life and Environmental Sciences, University of Sydney, Sydney, NSW, Australia Department of Orthopaedic SurgeryJohns Hopkins University School of MedicineBaltimoreMDUSA; State Key Laboratory of Oral DiseasesWest China Hospital of StomatologySichuan UniversityChengduPR China Guangdong Institute of Nephrology Southern Medical University Guangzhou China Department of Pediatric Dentistry, College of Dentistry, University of Illinois at Chicago, Chicago, Illinois; State Key Laboratory of Oral Diseases, Sichuan University, Chengdu, China Department of Pharmacology, National University of Singapore, Clinical Research Centre, Singapore; Memory Aging and Cognition Centre, National University Health System, Singapore State Key Laboratory of Transducer Technology, Shanghai Institute of Microsystem and Information Technology, Chinese Academy of Sciences, Shanghai 200050, China Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry, Chemical Engineering and Materials Science Soochow University Suzhou 215123 P. R. China State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi 214122, China Department of General Surgery Nanjing Jiangning Hospital 211100 Nanjing Jiangsu China Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, MOE Laboratory for Computational Physical Science, Department of Chemistry, Fudan University, Shanghai 200433, China Heat Biologics, Inc., Durham, NC, USA Office on Smoking and Health, National Center for Chronic Disease Prevention and Health Promotion, Centers for Disease Control and Prevention, Atlanta, GA, USA Laboratory for Stem Cell and Regenerative Medicine, Affiliated Hospital of Weifang Medical University, Weifang, China; School of Life Science and Technology, Weifang Medical University, Weifang, China Department of Pharmacology; College of Pharmaceutical Sciences; Soochow University; Suzhou 215123 People's Republic of China; Cyrus Tang Hematology Center; Soochow University; Suzhou 215123 People's Republic of China 5th Medical Department, University Hospital Mannheim, Heidelberg University , Mannheim, Germany Program in Protease and Matrix Biology, Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama Beijing Key Laboratory of Applied Experimental Psychology, Faculty of Psychology, Beijing Normal University, Beijing, China 1Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, Massachusetts. Department of Chemistry; Renmin University of China; Beijing 100872; China From the Department of Medicine/Heart and Vascular Center, Emory University School of Medicine (A.V.F., M.J., R.P., V.K., T.D., C.R., T.E., S.L.), Atlanta, Ga; CVPath Institute Inc (G.N., X.X., Q.C., E.A., F.D.K., R.V.), Gaithersburg, Md; Department of Medicine/Cardiovascular Research Center, Massachusetts General Hospital (H.K.G.), Boston, Mass; and Boston Scientific (M.E.), Natick, Mass. Department of Immunology and Host Defenses, Ehime University School of Medicine, Ehime, Japan State Key Laboratory of Oral Diseases; West China Hospital of Stomatology; Sichuan University; Chengdu China College of Animal Science and Technology Yangzhou University Yangzhou China; Joint International Research Laboratory of Agriculture & Agri‐Product Safety, Ministry of Education Yangzhou University Yangzhou China Department of Drug Metabolism, Merck Research Laboratories, West Point, Pennsylvania 19486 Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, Zhejiang, China Key Laboratory of Pesticide & Chemical Biology (CCNU), Ministry of Education and Department of Chemistry, Central China Normal University, Wuhan 430079, China, and State Key Laboratory for Physical Chemistry of Solid Surfaces, College for Chemistry and Chemical Engineering, Center for Theoretical Chemistry, Xiamen University, Xiamen 361005, China Institute of Oncologic Pathology, Medical College of Shantou University, Shantou, China Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong, China; National Clinical Research Center for Kidney Disease, Guangzhou, Guangdong, China; State Key Laboratory of Organ Failure Research, Guangzhou, Guangdong, China; Guangdong Provincial Institute of Nephrology, Guangzhou, Guangdong, China; Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou, Guangdong, China cWuxi No.2 People’s Hospital, Wuxi, China Collaborative Innovation Center of Chemistry for Energy Materials, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, MOE Laboratory for Computational Physical Science, Department of Chemistry, Fudan University, Shanghai, 200433, China Liver Cancer Institute & Zhongshan Hospital of Fudan University, Shanghai 200032, PR China Shanghai Institute of Thoracic Oncology Shanghai Chest Hospital Shanghai Jiao Tong University School of Medicine No. 241, West Huaihai Road Shanghai 200030 P. R. China State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China Department of Pharmacology, Yong Loo Lin School of Medicine National University of Singapore Singapore Singapore; Memory Ageing and Cognition Centre National University Health System Singapore Singapore Department of Digestion, Zhongnan Hospital of Wuhan University, Wuhan, P.R. China Chinese Academy of Sciences; University of Science and Technology of China Liver Cancer Institute, Zhongshan Hospital, Fudan University , Shanghai , China Key Laboratory of Modern Acoustics, Institute of Acoustics and School of Physics, Collaborative Innovation Center of Advanced Microstructures, Nanjing University 1 , Nanjing 210093, China Memory Aging and Cognition Center , Departments of Pharmacology and Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore; School of Public Health and the 2nd Affiliated Hospital of Zhejiang University School of Medicine , Hangzhou 310058, China National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, China. Henan Provincial Engineering Laboratory of Insects Bio-reactor, Henan Provincial Engineering and Technology Center of Health Products for Livestock and Poultry, Nanyang Normal University , Nanyang , 473061 , PR China 2National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland. Departments of Physics, Electrical Engineering and Computer Science, and Materials Science and Engineering, University of Michigan, Ann Arbor, Michigan 48109, and Departments of Electrical Engineering and Chemical Engineering, Princeton University, Princeton, New Jersey 08544 School of Mathematics Science, Anhui University, Hefei 230039, P.R. China College of Communications Engineering, Army Engineering University of PLA, Nanjing 210007, China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu Sichuan China Wenzhou Medical University, Wenzhou, Zhejiang, China Institute of Petrochemistry, Heilongjiang Academy of Sciences, Harbin 150040, China Hand‐Foot Surgery Nursing Platform The First Hospital of Jilin University Changchun 130021 China Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China. Department of Pathogenic Biology, School of Public Health, Southern Medical University, Guangzhou, China. College of Food Science and Engineering, Yangzhou University, Yangzhou, China Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China. [email protected]. Texas Children’s Cancer Center, Department of Pediatrics 1 , 2; Department of Pathology and Immunology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030 1 , 2 Fudan University 1 Collaborative Innovation Center of Chemistry for Energy Materials, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, MOE Laboratory for Computational Physical Science, Department of Chemistry, , Shanghai 200433, China Department of Civil & Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States Xiamen University 1 State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, , Xiamen 361005, China College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou 350002, China. Department of Thoracic Surgery, First Affiliated Hospital of Guangzhou Medical University, Guangzhou 510120, China; Guangzhou Institute of Respiratory Diseases and China State Key Laboratory of Respiratory Disease, Guangzhou 510120, China; National Respiratory Disease Clinical Research Center, Guangzhou 510000, China Institute of Chemical Materials; China Academy of Engineering Physics; Mianyang; China; College of Environment and Safety Engineering Department of Neurology State Key Lab of Biotherapy and Cancer center West China Hospital Sichuan University and Collaborative Innovation Center for Biotherapy Chengdu Sichuan China Department of Dermatology, Shanghai Skin Disease Hospital, School of Medicine, Tongji University, Shanghai, China;; Institute of Psoriasis, School of Medicine, Tongji University, Shanghai, China Laboratory for Tissue Engineering and Regeneration School of Stomatology Shandong University Jinan Shandong China Merck Research Laboratories, West Point, Pennsylvania 19486 Department of Implantology, School and Hospital of Stomatology, Cheeloo College of Medicine Shandong University & Shandong Provincial Key Laboratory of Oral Tissue Regeneration & Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration Jinan Shandong China Co-Innovation Center for Sustainable Forestry in Southern China, College of Biology and the Environment, Nanjing Forestry University, No. 159 Longpan Road, Nanjing, Jiangsu 210037, China MRC National Institute for Medical Research, The Ridgeway, London NW7 1AA, UK State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology College of Chemical Engineering Zhejiang University of Technology Hangzhou, Zhejiang Province 310014 P. R. China Key Laboratory of Drug Target and Drug for Degenerative Disease of Jiangsu Province, Nanjing University of Chinese Medicine, Nanjing 210023, China State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China Cancer Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang 310003, P.R. China Shanghai Kerlin Biomedical Technology Co., Ltd Shanghai China State Key Laboratory of Tree Genetics and Breeding, Northeast Forestry University, 26 Hexing Road, Harbin 150040, China School of Stomatology; Shandong University; Jinan; P. R. China Department of Pathology, Xingtai People’s Hospital Hebei Medical University, Key Laboratory for Renewable Energy, Chinese Academy of Sciences, Beijing Key Laboratory for New Energy Materials and Devices, Institute of Physics, Chinese Academy of Sciences, Zhongguancun South Third Street 8, Haidian District, Beijing 100190, China Institute of Space Medico-Engineering, Beijing, China. Department of Chemistry, Xiamen University, Xiamen 361005, Fujian, China Materials and Process Simulation Center (MC 139-74), California Institute of Technology, Pasadena, CA 91125 National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Nanfang Hospital, Southern Medical University, Guangzhou, China; Department of Vascular Surgery, Zhongshan Hospital of Fudan University, Shanghai 200032, China. Zhejiang Key Laboratory of Carbon Materials; College of Chemistry and Materials Engineering; Wenzhou University; Wenzhou 325027, P. R. China Australian Institute for Bioengineering and Nanotechnology and ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of Queensland, St Lucia, Queensland 4072, Australia Cancer Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou, Zhejiang, China Department of Clinical Epidemiology and Center of Evidence-Based Medicine, The First Hospital of China Medical University Shenyang, Liaoning, People's Republic of China. Key Laboratory of Cancer Etiology and Intervention, University of Liaoning Province Shenyang, Liaoning, People's Republic of China. Productivity Center of Jiangsu Province Nanjing 210042, China. Key Laboratory of Material Chemistry for Energy Conversion and Storage, Ministry of Education; Hubei Key Laboratory of Bio-inorganic Chemistry & Materia Medica; School of Chemistry and Chemical Engineering, Huazhong University of Science and Technology, Wuhan 430074, China Department of Neurological Examination The Affiliated Hospital of Qingdao University Qingdao China Division of Health Risk Factors Monitoring and Control, Shanghai Municipal Center for Disease Control and Prevention, Shanghai 200336, China; School of Public Health, Key Lab of Public Health Safety of the Ministry of Education, Fudan University, Shanghai 200032, China State Key Laboratory of Molecular Oncology, Center for Cancer Precision Medicine, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Chongqing Key Laboratory of Neurology, Department of Neurology, the First Affiliated Hospital of Chongqing Medical University, Chongqing, China State Key Laboratory of Oral Diseases West China Hospital of Stomatology, Sichuan University Chengdu China; Department of Endodontics and Operative Dentistry West China Hospital of Stomatology, Sichuan University Chengdu China State Key Laboratory of Oral Diseases, Sichuan University, No. 14 Ren Min South Street, Chengdu, China. Chinese Academy of Sciences State Key Laboratory of Molecular Reaction Dynamics and Center for Theoretical & Computational Chemistry, Dalian Institute of Chemical Physics, , Dalian 116023, People's Republic of China Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310003, China College of Stomatology, Key Lab of Oral Biomedicine of Shandong Province, Shandong University, Jinan, P. R. China, 250012, and Department of Pharmaceutical Sciences, College of Pharmacy, Department of Otolaryngology, University of Michigan, Ann Arbor, MI 48109 Department of chemistry, State Key Laboratory of Physical Chemistry of Solid Surfaces, Fujian Provincial Key Laboratory of Theoretical and Computational Chemistry, College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 People's Republic of China; Department of Chemistry, Collaborative Innovation Center of Chemistry for Energy Materials, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, MOE Laboratory for Computational Physical Science Fudan University Shanghai 200433 People's Republic of China Hubei Key Laboratory of Animal Nutrition and Feed Science, School of Animal Science and Nutrition Engineering, Wuhan Polytechnic University, Wuhan, China Affiliated Hangzhou First People's Hospital and Institute of Environmental Medicine Zhejiang University School of Medicine, Hangzhou Zhejiang China Key Laboratory for Organic Electronics and Information Displays & Jiangsu Key Laboratory for Biosensors; Institute of Advanced Materials (IAM); Jiangsu National Synergetic Innovation Center for Advanced Materials (SICAM); Nanjing University of Posts & Telecommunications (NUPT); Nanjing 210023 Materials and Process Simulation Center, Beckman Institute, California Institute of Technology, Pasadena, CA 91125; and State Key Laboratory for Physical Chemistry of Solid Surfaces, Center for Theoretical Chemistry, Department of Chemistry, Xiamen University, Xiamen 361005, China Department of Geriatrics, Hematology and Oncology Ward, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China State Key Laboratory of Information Photonics and Optical Communications and School of Science, Beijing University of Posts and Telecommunications, Beijing 100876, China Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices; Institute of Functional Nano and Soft Materials (FUNSOM); Collaborative Innovation Center of Suzhou Nano Science and Technology; Soochow University; Suzhou 215123 Division of Nephrology, Nanfang Hospital, Southern Medical University, Guangzhou, China2National Clinical Research Center for Kidney Disease, Guangzhou, China Institute of Molecular Sciences and Engineering, Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao 266237, People’s Republic of China Beijing Key Laboratory of Gene Resource and Molecular Development College of Life Sciences Beijing Normal University Beijing China Key Laboratory of Superlight Materials and Surface Technology, Ministry of Education, Institute of Advanced Marine Materials, College of Materials Science and Chemical Engineering Harbin Engineering University Harbin China School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, 103 Wenhua Road, Shenhe District, Shenyang, 110016, P. R. China, Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, Department of Chemical Biology, College of Chemistry, Peking University, Beijing, P. R. China, 100871, and VivoQuest, Inc., 711 Executive Boulevard, Valley Cottage, New York 10989 Henan Key Laboratory of Polyoxometalate Chemistry College of Chemistry and Chemical Engineering Henan University Kaifeng 475004 China School of Public Health, Central South University, Changsha 410008, China. Fine Chemical Industry Research Institute and PCFM Lab, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, PR China Henan Key Laboratory of Polyoxometalate Chemistry, College of Chemistry and Chemical Engineering, Henan University, Kaifeng, Henan 475004, China Department of Aviation Oil and Material, Air Force Logistics Academy, Xuzhou 221000, China Department of Bone Marrow Transplant, Hebei Yanda Lu Daopei Hospital, Langfang, China Huaxi MR Research Center (HMRRC), Department of Radiology West China Hospital of Sichuan University Chengdu People's Republic of China College of Life Sciences, Capital Normal University, 105 3rd Ring Road West, Beijing, 100048, People's Republic of China. Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, United States Department of Traditional Chinese Medicine 1, Cangzhou Central Hospital, Cangzhou, People's Republic of China From the Cardiovascular Division and Lillehei Heart Institute (H.W., D.K., X.X., T.T., R.J.B., Y.C.) and Department of Laboratory Medicine and Pathology, Center for Immunology, Department of Medicine, Masonic Cancer Center (B.J.B., Y.S.), University of Minnesota Medical School, Minneapolis; Department of Pharmacology and Toxicology, University of Graz, Austria (J.F.); and Department of Cardiology, Shanghai Tenth People’s Hospital of Tongji University, China (L.H., Y.X., J.-b.G.). Department of Medical Physiology, Texas A&M University Health Science Center, Temple, TX, USA; Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing Maternal and Child Health Care Hospital, Beijing, China Department of Pharmacy, Affiliated Hospital of Nantong University, Nantong, China Department of Chemistry and Institute of Physical Chemistry, State Key Laboratory for Physical Chemistry of Solid Surfaces and Center for Theoretical Chemistry, Xiamen University, Xiamen 361005, China Xiamen University, 2 Department of Chemistry, Xiamen, Fujian 361005, People’s Republic of China School of Chemical and Biological Engineering Lanzhou Jiaotong University Lanzhou Gansu China From the Cardiovascular Division (X.H., X.X., Z.L., P.Z., J.F., J.L.H., R.J.B., Y.C.) and Lillehei Heart Institute (X.H., P.Z., J.L.H., R.J.B., Y.C.), University of Minnesota, Minneapolis, MN; Molecular and Cellular Biology Laboratory (Y.Z., Y.X., Y.H.), Beijing Anzhen Hospital, Capital Medical University, Anzhenli, Chaoyang District, Beijing, China; Institut National de la Santé et de la Recherche Médicale (B.V.), U1016, Institut Cochin, Centre National de la Recherche Scientifique, UMR8104,... School of Mechanical Engineering, Xi’an University of Science and Technology, Xi’an 710054, China; Shaanxi Province Key Laboratory of Intelligent Detection and Control of Mining Electromechanical Equipment, Xi’an 710054, China Department of Biochemistry and Molecular Biology, College of Basic Medicine, Hebei Medical University, Shijiazhuang 050017, China; Key Laboratory of Neural and Vascular Biology of Ministry of Education, Shijiazhuang 050017, China; Key Laboratory of Medical Biotechnology of Hebei Province, Hebei Medical University, Shijiazhuang 050017, China From the Department of Chinese Medicine, Shanghai Tenth People's Hospital of Tongji University, Shanghai, China (X.L., Y.W.); Cardiovascular Division, Lillehei Heart Institute, University of Minnesota Medical School, Minneapolis (X.L., D.K., Z.L., X.X., J.F., H.W., J.H., R.J.B., Y.C.); College of Life Science, University of Chinese Academy of Science, Beijing, China (Z.L.); Department of Biology and The Huck Institutes of the Life Sciences, Pennsylvania State University, University Park (D.R.C.);... Office on Smoking and Health Centers for Disease Control and Prevention Atlanta GA Department of Chemistry; Collaborative Innovation Centre of Chemistry for Energy Materials (iChEM); Shanghai Key Laboratory of Molecular Catalysts and Innovative Materials; Fudan University; Shanghai Department of General Surgery Nanjing Jiangning Hospital Hushan Road No. 169 211100 Nanjing Jiangsu China Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, China State Key Laboratory for Physical Chemistry of Solid Surfaces & Department of Chemistry, Xiamen University, Xiamen 361005, China Division of Nephrology, Nanfang Hospital, Southern Medical University; National Clinical Research Center for Kidney Disease; State Key Laboratory of Organ Failure Research; Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research, Guangzhou Regenerative Medicine and Health Guangdong Laboratory, Guangzhou, China Department of Radiation Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China Department of Neurosurgery General Hospital of Chinese Military Beijing China Department of Obstetrics and Gynecology, West China Second University Hospital, Sichuan University/Key Laboratory of Birth Defects and Related Diseases of Women and Children (Sichuan University), Ministry of Education, Chengdu, China Key Laboratory for Renewable Energy and Beijing Key Laboratory for New Energy Materials and Devices, Institute of Physics, Chinese Academy of Sciences, Beijing 100190, P. R. China School of Materials Engineering Changshu Institute of Technology Changshu Jiangsu 215500 P. R. China The State Key Laboratory of Oral Diseases and the National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, China; The Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, China MOE Key Laboratory for Analytical Science of Food Safety and Biology State Key Laboratory of Photocatalysis on Energy and Environment College of Chemistry Fuzhou University Fuzhou 350116 P. R. China Department of Oral Maxillofacial Surgery, School of Stomatology, Shandong University, Jinan, Shandong 250012, P.R. China Department of Traditional Chinese Medicine Cangzhou Central Hospital Cangzhou Hebei China Key Laboratory of Plant Hormones and Development Regulation of Chongqing, School of Life Sciences, Chongqing University, Chongqing, China Department of Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294 Advaccine Biopharmaceutics (Suzhou) Co. Ltd, Suzhou, People’s Republic of China Division of Infectious Diseases, State Key Laboratory of Biotherapy and Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, Sichuan 610041, PR China Department of General Surgery The Second Affiliated Hospital of Xi'an Jiaotong University Xi'an China a Department of Vascular Surgery Zhongshan Hospital affiliated to Fudan University, Shanghai, People's Republic of China Department of Pharmacology, National University of Singapore, Singapore, Singapore; Zhejiang University School of Medicine, Hangzhou, Zhejiang, China General Intensive Care Unit, Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, PR China State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China 116023 Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang Province 310003, China Division of Cardiology, Department of Medicine, The University of Hong Kong, Queen Mary Hospital , Hong Kong, 999077 , China Department of Gastroenterology and Hepatology, Tianjin Medical University General Hospital, Tianjin, China Shool of Stomatology, Shandong University, Jinan 250012, China. [email protected] Department of Implantology, School and Hospital of Stomatology, Shandong University, Shandong Key Laboratory of Oral Tissue Regeneration and Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, Shandong 250012, P.R. China Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, North Carolina, USA Fine Chemical Industry Research Institute and PCFM LIFM Lab School of Chemistry Sun Yat-sen University Guangzhou 510275 P. R. China Department of Blood Transfusion, The Second Affiliated Hospital, Hengyang Medical School, University of South China, Hengyang, Hunan, China College of Life Sciences; Hunan Normal University; Changsha China; College of Life Sciences; Hubei University; Wuhan China Information Center Beijing Children’s Hospital Capital Medical University National Center for Children’s Health Beijing China Department of Pharmaceutical Sciences Zunyi Medical University Zhuhai Guangdong China Fudan University 2 Department of Chemistry, , Shanghai 200433, People's Republic of China Division of Cardiology, The First Affiliated Hospital of Soochow University, 188 Shizi Street, Suzhou 215006, China Department of Anesthesiology and Perioperative Medicine, Shanghai Key Laboratory of Anesthesiology and Brain Functional Modulation, Clinical Research Center for Anesthesiology and Perioperative Medicine, Translational Research Institute of Brain and Brain‐Like Intelligence, Shanghai Fourth People's Hospital, School of Medicine Tongji University Shanghai China Department of Joint Surgery, Honghui Hospital, Xi’an Jiaotong University, Xi’an, Shaanxi, China First Affiliated Hospital of Guangzhou Medical University, State Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, Guangzhou, China. Department of Gastroenterology and Hepatology, General Hospital, Tianjin Medical University, Tianjin 300052, China State Key Laboratory of Molecular Reaction Dynamics, Dalian Institute of Chemical Physics Chinese Academy of Sciences Dalian 116023 China State Key Laboratory for Physical Chemistry of Solid Surfaces and Center for Theoretical Chemistry, Department of Chemistry & Institute of Physical Chemistry, Xiamen University, Xiamen, 361005, China Institute of Genomic Medicine, Wenzhou Medical University, Wenzhou, China School of Mechanical Engineering and Birck Nanotechnology Center, Purdue University, West Lafayette, IN 47907; Graduate School Experimental Plant Sciences, Department of Plant Physiology (X.X., E.V., D.V.),; and Department of Plant Cytology and Morphology (X.X., A.A.M.v.L.), Wageningen Agricultural University, Arboretumlaan 4, 6703 BD Wageningen, The Netherlands College of Animal Science and Technology, Yangzhou University, Yangzhou 225009, PR China; Joint International Research Laboratory of Agriculture & Agri-Product Safety, Ministry of Education, Yangzhou University, Yangzhou 225009, PR China Departments of Chemistry and Physical Medicine and Rehabilitation, University of Minnesota, Minneapolis, Minnesota 55455 Department of Urology, The First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, Zhejiang, China Department of Chemistry, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, MOE Laboratory for Computational Physical Science, Collaborative Innovation Center of Chemistry for Energy Materials Fudan University Shanghai 200433 China School of Stomatology, Shandong University, Jinan, P.R. China.; Shandong Provincial Key Laboratory of Oral Biomedicine, Jinan, P.R. China. Department of Biochemistry & Molecular Biology; University of Louisville School of Medicine; Louisville Kentucky Hubei Provincia Key Laboratory for Protection and Application of Special Plant Germplasm in Wuling Area of China, Key Laboratory of State Ethnic Affairs Commission for Biological Technology, College of Life Science, South-Central University for Nationalities, Wuhan, China College of Horticulture, Shenyang Agricultural University, Shenyang, Liaoning, China; Collaborative Innovation Center of Protected Vegetable Surround Bohai Gulf Region, Shenyang, Liaoning, China; Key Laboratory of Protected Horticulture (Shenyang Agricultural University) Ministry of Education, Shenyang, Liaoning, China Wuxi No.2 People’s Hospital, Wuxi, Jiangsu, China; Department of Neurology; The First Affiliated Hospital of Chongqing Medical University; Chongqing 400016 China Department of Rehabilitation Medicine Children's Hospital of Nanjing Medical University Nanjing China Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou 215123 P. R. China Xiamen University 1 State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, , Xiamen 361005, China; Fudan University 2 Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, MOE Laboratory for Computational Physical Science, Department of Chemistry, , Shanghai 200433, China State Key Laboratory of Physical Chemistry of Solid Surfaces, College for Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China, and Department of Theoretical Chemistry, School of Biotechnology, Royal Institute of Technology, KTH, Sweden Department of Otolaryngology, Yan’an Hospital of Kunming City, Yunnan 650031, P.R. China Department of Neurosurgery General Hospital of PLA Beijing China School of Electronic Science and Engineering National University of Defense Technology Changsha Hunan 410073 China Hubei Key Laboratory of Animal Nutrition and Feed Science, Hubei Collaborative Innovation Center for Animal Nutrition and Feed Safety, Wuhan Polytechnic University, Wuhan, China School of Public Health, The Second Affiliated Hospital of School of Medicine Zhejiang University Hangzhou Zhejiang P. R. China; Key Laboratory of Intelligent Preventive Medicine of Zhejiang Province Hangzhou Zhejiang P. R. China; Department of Pharmacology Yong Loo Lin School of Medicine Memory, Ageing, and Cognition Centre (MACC) National University of Singapore Singapore Singapore Information Center Beijing Children's Hospital Capital Medical University National Center for Children's Health Beijing China MOE Key Laboratory of Macromolecular Synthesis and Functionalization; Department of Polymer Science and Engineering; Zhejiang University; Hangzhou 310027; P. R. China Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Mukogawa, Nishinomiya, Japan; Department of Digestive Diseases, Tianjin Medical University General Hospital, Tianjin, China Key Laboratory of Molecular Biology for High Cancer Incidence Coastal Chaoshan Area; Shantou University Medical College; Shantou 515041; China; Institute of Oncologic Pathology Department of Emergency Medicine, The First Affiliated Hospital of Soochow University Suzhou 215006, Jiangsu, P. R. China. Department of Imaging, Tianjin Hospital of ITCWM, Nankai Hospital, Tianjin, 300100, PR China Department of Neurology Daqing Oilfield General Hospital Daqing Heilongjiang Province China Department of UrologyFirst Affiliated HospitalSchool of MedicineZhejiang University Hangzhou China Division of Nephrology, Nanfang Hospital, Southern Medical University, National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangzhou Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.; Program in Protease and Matrix Biology, University of Alabama at Birmingham, Birmingham, AL 35294, USA. National Engineering Laboratory for VOCs Pollution Control Technology and Equipment, Guangdong Provincial Key Laboratory of Atmospheric Environment and Pollution Control, School of Environment and Energy, South China University of Technology, 510006 Guangzhou, China State Key Laboratory for Physical Chemistry of Solid Surfaces, College for Chemistry and Chemical Engineering, Center for Theoretical Chemistry, Xiamen University, Xiamen 361005, China Department of Chemistry Hong Kong University of Science and Technology Clear Water Bay, Kowloon Hong Kong China Materials and Process Simulation Center, Beckman Institute, MC 139-74, California Institute of Technology, Pasadena, CA 91125 Hangzhou Institute of Advanced Studies, Zhejiang Normal University, 1108 Gengwen Road, Hangzhou 311231, China Department of Molecular Medicine, Osaka University Graduate School of Medicine (C-4), Suita, Osaka 565-0871, Japan Jiangsu Key Laboratory for Translational Research and Therapeutics of Neuro-Psycho- Diseases, Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, Jiangsu, 215123, P. R. China; Suzhou Institute of Systems Medicine, Center of Systems Medicine, Chinese Academy of Medical Sciences, Suzhou, 215123, P. R. China Technology Center of Angang Steel Company Limited, 63 Wuyi Road, Anshan 114009, China State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan, 61004, China Jiangxi Province Key Laboratory of Preventive Medicine School of Public Health Nanchang University Nanchang P. R. China State Key Laboratory of Molecular Oncology Cancer Institute (Hospital), Peking Union Medical College and Chinese Academy of Medical Sciences Beijing China State Key Laboratory for Physical Chemistry of Solid Surfaces, Center for Theoretical Chemistry, Department of Chemistry, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005, China, and Department of Chemistry, Hong Kong University of Science and Technology, Kowloon, Hong Kong Laboratory for Stem Cell and Regenerative Medicine, The Affiliated Hospital of Weifang Medical University, Weifang, Shandong, China; Department of Urology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. Key Laboratory of Urban Agriculture (North China) of Ministry of Agriculture, College of Biological Science and Engineering, Beijing University of Agriculture, Beijing 102206, China Xiamen University State Key Laboratory of Physical Chemistry of Solid Surfaces, Center for Theoretical Chemistry, College for Chemistry and Chemical Engineering, , Xiamen 361005, People’s Republic of China 1Molecular Medicine Program, Department of Medicine, Boston University Medical Center, Boston, Massachusetts and Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, 310000, Zhejiang Province, China State Key Laboratory of Molecular Oncology Center for Cancer Precision Medicine National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital Chinese Academy of Medical Sciences and Peking Union Medical College Beijing China Australian Institute for Bioengineering and Nanotechnology, University of Queensland, St Lucia, Queensland 4072, Australia; ARC Centre of Excellence in Convergent Bio-Nano Science and Technology, The University of Queensland, St Lucia, Queensland 4072, Australia Livestock, Aquaculture and Technology Promotion and Service Center of Conghua District, Guangzhou 510000, China Hebei Clinical Research Center for Birth Defects, Department of Reproductive Medicine, The Second Hospital of Hebei Medical University, Shijiazhuang 050000, China State Key Laboratory of Oral Diseases and National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China; Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China Department of Pharmacology, National University of Singapore, Singapore; Memory Ageing and Cognition Centre, National University Health System, Singapore Laboratory of Developmental Biology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 20850, USA. 1Department of Pediatrics, Texas Children's Cancer Center, Center for Cell and Gene Therapy, Baylor College of Medicine, Houston, Texas. Robot Vision Group, National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing 100080, China. Univ. of Dundee at JHI Invergowrie Dundee DD2 5DA UK; Hubei Provincial Key Lab. for Protection and Application of Special Plants in Wuling Area of China, College of Life Sciences, South‐Central Univ. for Nationalities Wuhan China 430074 Institute of Applied Electrochemistry Beijing University of Chemical Technology Beijing 100029 P. R. China; Beijing OriginWater Technology Co., Ltd. Beijing 101400 P. R. China Department of Orthopedic Trauma, Honghui Hospital, Xi’an Jiaotong University, Xi’an, People’s Republic of China Department of Cardiothoracic Surgery, First Affiliated Hospital of Guangzhou Medical University, Guangzhou, Guangdong, China (mainland) CAS Key Laboratory of Marine Ecology and Environmental Sciences Institute of Oceanology, Chinese Academy of Sciences Qingdao China; Functional Laboratory of Marine Ecology and Environmental Science Laoshan Laboratory Qingdao China; Center for Ocean Mega‐Science Chinese Academy of Sciences Qingdao China State Key Laboratory of Oral Diseases National Clinical Research Center for Oral Diseases, West China Hospital of Stomatology Sichuan University Chengdu China; Department of Cariology and Endodontics, West China Hospital of Stomatology Sichuan University Chengdu China School of Instrument Science and Opto-Electronic Engineering, Hefei University of Technology , Hefei, Anhui 230009, China 1State Key Laboratory of Molecular Oncology, Tianjin Neurological Institute; Departments of Neurosurgery and Neurology, Tianjin Medical University General Hospital, Tianjin, China. Chern Institute of Mathematics and LPMC, Nankai University, Tianjin, People's Republic of China Department of Dermatology, Shanghai Skin Disease Hospital Tongji University School of Medicine Shanghai China State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Department of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, P. R. China Department of Chemistry Fudan University 220 Handan Road 200433 Shanghai China; Collaborative Innovation Center of Chemistry for Energy Materials Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, MOE Laboratory for Computational Physical Science 200438 Shanghai China Division of Gastroenterology, Department of Internal Medicine, Hyogo College of Medicine, Nishinomiya, Hyogo 663‑8501, Japan Cardiovascular Division, University of Minnesota, Minneapolis, Minnesota.; Lillehei Heart Institute, University of Minnesota, Minneapolis, Minnesota. Key Laboratory for Renewable Energy; Chinese Academy of Sciences; Beijing 100190 PR China; Beijing Key Laboratory for New Energy Materials and Devices; Beijing 100190 PR China; Institute of Physics; Chinese Academy of Sciences; Beijing 100190 PR China State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University Chengdu China Department of Pediatrics, Texas Children’s Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA Department of Implantology, School and Hospital of Stomatology, Shandong University, Shandong 250012, China; Shandong Provincial Key Laboratory of Oral Tissue Regeneration, Shandong 250012, China; Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Shandong 250012, China State Key Laboratory of Oral Diseases, West China Hospital of Stomatology, Sichuan University , Chengdu, China Department of Oncology, The Second Affiliated Hospital of Shandong First Medical University, Tai’an, China Jiangsu Key Laboratory of Translational Research and Therapy for Neuro-Psycho-Diseases, Department of Pharmacology, College of Pharmaceutical Sciences, Soochow University, Suzhou, China Department of Oral and Maxillofacial Surgery, The Second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China. [email protected] From the Departments of Pharmacology (X.X., S.H., E.J.Y.C., C.L.-H.C.) and Psychology (S.L.C.) and Academic Medicine Research Institute, Duke-NUS Graduate Medical School (M.K.I.), National University of Singapore, Singapore, Singapore; Memory Aging and Cognition Centre, National University Health System, Singapore, Singapore (X.X., S.H., E.J.Y.C., M.K.I., N.V., C.L.-H.C.); and Raffles Neuroscience Centre, Raffles Hospital, Singapore, Singapore (N.V.). Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, MOE Laboratory for Computational Physical Science, Collaborative Innovation Center of Chemistry for Energy Materials, Department of Chemistry, Fudan University, Shanghai 200433, China Advaccine Biopharmaceutics (Suzhou) Co., Ltd., Suzhou 215000, China Collaborative Innovation Center of Chemistry for Energy Materials, Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials, MOE Laboratory for Computational Physical Science, Department of Chemistry, Fudan University, Shanghai 200433, China Jilin University The Institute for Tropical Medicine, Faculty of Basic Medical Science, Kunming Medical University, Kunming, China Department of Inflammation, Wyeth Research, Cambridge, Massachusetts; and Department of Research, Mount Sinai Medical Center, Miami Beach, Florida Department of Nuclear Medicine, The First Affiliated Hospital of Soochow University, Suzhou, China Key Laboratory of Pesticide & Chemical Biology (CCNU), Ministry of Education, College of Chemistry, Central China Normal University, Wuhan 430079, P R China, State Key Laboratory of Physical Chemistry of Solid Surfaces, College of Chemistry and Chemical Engineering, Center for Theoretical Chemistry, Xiamen University, Xiamen 361005, P R China, and College of Life Science, Central China Normal University, Wuhan 430079, P R China General Surgery Department, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, 230032, PR China Division of Pulmonary, Allergy, and Critical Care Medicine, Department of Medicine; UAB Program in Protease and Matrix Biology, and Office on Smoking and Health National Center for Chronic Disease Prevention and Health Promotion Centers for Disease Control and Prevention Atlanta GA USA Department of Vascular Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China School of Chemistry and Chemical Engineering, Key Laboratory of Materials-Oriented Chemical Engineering of Xinjiang Uygur Autonomous Region, Shihezi University, Shihezi 832003, China Department of Entomology, College of Plant Protection, South China Agricultural University, Guangzhou 510642, Guangdong Province, China; The Research Institute of Resources Insects, Chinese Academy of Forestry, Kunming 650224, Yunnan Province, China Program for Population Genetics, Harvard School of Public Health, Boston, Massachusetts, USA Department of Anesthesiology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China School of Materials Science and Engineering Nanyang Technological University Singapore 639798 Singapore; Department of Chemistry University of Massachusetts Lowell Lowell MA 01854 USA State Key Laboratory Breeding Base of Green‐Chemical Synthesis Technology College of Chemical Engineering Zhejiang University of Technology Hangzhou Zhejiang 310014 China Department of Neurology, the First Affiliated Hospital of Chongqing Medical University Chongqing Key Laboratory of Neurology Chongqing PR China Epigenetics and Stem Cell Biology Laboratory, National Institute of Environmental Health Sciences , Research Triangle Park, NC, USA Department of Gastroenterology and Hepatology Tianjin Medical University General Hospital Tianjin China; Tianjin Institute of Digestive Disease Tianjin Medical University General Hospital Tianjin China China Regional Research Center, International Centre for Genetic Engineering and Biotechnology Taizhou 225300, Jiangsu, P. R. China. Center for Self-propelled Nanotechnologies, College of Biotechnology, Suzhou Industrial Park Institute of Services Outsourcing Suzhou 215125, Jiangsu, P. R. China. Key Laboratory of Drug Quality Control and Pharmacovigilance, Ministry of Education, China Pharmaceutical University, Nanjing, China; Department of Pharmaceutical Analysis, China Pharmaceutical University, Nanjing, China Suzhou Institute of Systems Medicine Chinese Academy of Medical Science and Peking Union Medical College Suzhou China Department Of Gastroenterology, Digestive Disease Hospital The First Affiliated Hospital of Nanchang University Nanchang China; JiangXi Clinical Research Center for Gastroenterology Nanchang China Institute of Molecular Sciences and Engineering, Institute of Frontier and Interdisciplinary Science, Shandong University, Qingdao 266237, P. R. China Medical College of Georgia, Augusta University Department of Pharmacology and Toxicology , , Augusta, GA 30912 , USA Department of Neurobiology, Harbin Medical University, Key Laboratory of Heilongjiang Province, Harbin 150086, China. [email protected] Rady Children’s Institute for Genomic Medicine; Department of Neurosciences, University of California, San Diego Fine Chemical Industry Research Institute, PCFM and LIFM Lab, School of Chemistry, Sun Yat-sen University, Guangzhou 510275, P.R. China Department of Biochemistry and Center for Structural Biology, Vanderbilt University School of Medicine, Nashville, Tennessee 37232 State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, Sichuan University and Collaborative Innovation Center for Biotherapy, Chengdu, Sichuan 610065, China Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Institute of Functional Nano & Soft Materials, Collaborative Innovation Center of Suzhou Nano Science & Technology, Soochow University, Jiangsu, China 215123; State Key Laboratory of Oral Diseases; West China Hospital of Stomatology; Sichuan University; Chengdu 610041; China Program for Population Genetics and Department of Biostatistics Harvard School of Public Health Boston, Massachusetts Hubei University, China; Department of Gynecological Endocrinology, Beijing Obstetrics and Gynecology Hospital, Capital Medical University, Beijing, China; Beijing Maternal and Child Health Care Hospital, Beijing, China *Inflammation Biology Section, Laboratory of Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892; and Department of Chemistry, College of Chemistry and Chemical Engineering and State Key Laboratory of Physical Chemistry for Solid Surface, Xiamen University, Xiamen 361005, Fujian, People Republic of China, and Institute of Atomic and Molecular Sciences, Academia Sinica, Taipei 106, Taiwan, Republic of China Cardiac Intensive Care Center, Zhongshan Hospital, Fudan University, Shanghai, China; Department of Critical Care Medicine, Pan Long People’s Hospital, Kunming, China Key Laboratory of Industrial Biotechnology, Ministry of Education, School of Biotechnology, Jiangnan University, Wuxi, Jiangsu 214122, People’s Republic of China; State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, Jiangsu 214000, People’s Republic of China; School of Biotechnology, Jiangnan University, 1800 Lihu Avenue, Wuxi, Jiangsu 214122, People’s Republic of China Yuebei People’s Hospital, Guangdong, Shaoguan 512026, China Department of Chemistry Renmin University of China Beijing 100872 China; Jiangsu Key Laboratory of New Drug Research and Clinical Pharmacy, School of Pharmacy Xuzhou Medical University Xuzhou 221004 China Materials and Process Simulation Center, Division of Chemistry and Chemical Engineering (MC 139-74), California Institute of Technology, Pasadena, CA 91125, USA. Henan Provincial Engineering Laboratory of Insects Bio-reactor, Henan Provincial Engineering and Technology Center of Health Products for Livestock and Poultry, Nanyang Normal University, Nanyang 473061, China; Henan Provincial Engineering and Technology Center of Animal Disease Diagnosis and Integrated Control, Nanyang Normal University, Nanyang 473061, China State Key Laboratory of Electrical Insulation and Power Equipment, Center of Nanomaterials for Renewable Energy, School of Electrical Engineering, Xi’an Jiaotong University, Xi’an 710049, P.R. China State Key Laboratory of Southwestern Chinese Medicine Resources Chengdu China; School of Pharmacy Chengdu University of Traditional Chinese Medicine Chengdu China CAS Key Laboratory of Materials for Energy Conversion, Department of Materials Science and Engineering, University of Science and Technology of China, Hefei 230026, China Department of Hematology, The Affiliated Jiangyin Hospital of Southeast University Medical College, Jiangyin, Jiangsu, China From the Centre for Healthy Brain Ageing (J.W.L., J.D.C., R.J.C., H.B., D.M.L., N.A.K., P.S.S.), University of New South Wales, Sydney, Australia; Department of Neurology and Laboratory of Functional Neurosciences (O.G., M.B., M.R.), University Hospital of Amiens, France; Clinical Neurosciences (H.J., S.M., T.E.), Neurology, University of Helsinki and Helsinki University Hospital, Finland; Department of Internal Medicine (S.M.), Gerontology and Geriatrics Section, and Department of Cardiology (J.W.J... Institute of Functional Nano & Soft Materials (FUNSOM), Soochow University, Suzhou 215123, China;; Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices, Soochow University, Suzhou 215123, China;; Collaborative Innovation Center of Suzhou Nano Science and Technology, Soochow University, Suzhou 215123, China;; Joint International Research Laboratory of Carbon-Based Functional Materials and Devices, Soochow University, Suzhou 215123, China; Institute of Atmospheric Physics, Chinese Academy of Sciences, Beijing 100029, China. Texas Children's Cancer Center, Department of Pediatrics, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA College of Food Science and Engineering Yangzhou University Yangzhou P. R. China All authors: Harvard Medical School; J. Frank Wharam, Fang Zhang, Xin Xu, Stephen Soumerai, and Dennis Ross-Degnan, Harvard Pilgrim Health Care Institute, Boston, MA. Department of General Surgery, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi'an, Shaanxi 710004, China School of Chinese Pharmacy, Beijing University of Chinese Medicine School and Hospital of Stomatology, Cheeloo College of Medicine, Shandong University and Shandong Key Laboratory of Oral Tissue Regeneration and Shandong Engineering Laboratory for Dental Materials and Oral Tissue Regeneration, Jinan, Shandong, China (mainland) 1Department of Hematology, Affiliated Hospital of Weifang Medical University, Weifang, Shandong, China. Intensive Care Unit Department of Oral Surgery, The Second Affiliated Hospital of Zhejiang University School of Medicine, Hangzhou, Zhejiang 310009, P.R. China College of Chemical Engineering, Zhejiang University of Technology, Hangzhou, Zhejiang 310014, P. R. China Department of Urology School of Medicine First Affiliated Hospital of Zhejiang University Hangzhou China Division of Nephrology, Nanfang Hospital, Southern Medical University; National Clinical Research Center for Kidney Disease, State Key Laboratory of Organ Failure Research, Guangdong Provincial Institute of Nephrology, Guangdong Provincial Key Laboratory of Renal Failure Research College of Agronomy and Biotechnology, Southwest University Department of Transplantation the First Affiliated Hospital of Guangzhou Medical University Guangzhou China |
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