http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_c2c915e639251dac3c948edab05c9244
Outgoing Links
| Predicate | Object |
|---|---|
| family-name | Lu Yan Lu |
| name | Yan Lu |
| given-name | Yan |
| organization-name | Cancer center Zhejiang University Hangzhou 310058 China; Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases Department of Gynecologic Oncology Women's Hospital and Institute of Translational Medicine Zhejiang University School of Medicine Hangzhou Zhejiang 310029 China Department of Gynecologic Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi Zhuang Autonomous Region 530021, P.R. China Department of Chemical Biology and Therapeutics, St Jude Children’s Research Hospital, Memphis, Tennessee 38105 Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China Department of Medicine, University of Mississippi Medical Center, Jackson, Mississippi; and Department of Biochemistry and Molecular Biology (I.A., Y.L., L.J.S., S.M.B., R.L.L.), Quantitative Biology Initiative (S.M.B.), and Department of Plant Biology (R.L.L.), Michigan State University, East Lansing, Michigan 48824 Comparative Orthopaedic Research Laboratory, Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin Wake Forest University Department of Physics, , Winston-Salem, NC 27106, USA Faculty of Pharmacy Canadian Centre for Agri‐Food Research in Health and Medicine St. Boniface General Hospital Research Centre University of Manitoba Winnipeg MB Canada Anhui Province Key Laboratory of Medical Physics and Technology, Center of Medical Physics and Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui 230031, China Osteoporosis Research Center, Creighton University Medical Center, Omaha, Nebraska Department of Oncology, Shanghai Medical College, Fudan University, No. 270 DongAn Road, Shanghai 200032, China Audio and Acoustic Signal Processing Group, Research School of Engineering, Australian National University , Canberra, Australia Department of Dermatology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Hongo 7-3-1, Bunkyo-ku, Tokyo 113-0033, Japan; and MOE Key Laboratory of Mesoscopic Chemistry, MOE Key Laboratory of High Performance Polymer Materials and Technology, Jiangsu Key Laboratory of Advanced Organic Materials, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, China Department of Pharmaceutical Sciences, University of Tennessee, Health Science Center, Memphis, Tennessee 38163, United States Department of Internal Medicine , Jiaxing Second Hospital , 314000 , Jiaxing People′s Republic of China Tianjin Key Laboratory for Photoelectric Materials and Devices School of Materials Science & Engineering Tianjin University of Technology Tianjin 300384 China Northeast Petroleum University Beijing University of Technology 2 College of Mechanical Engineering and Applied Electronics Technology, , Beijing, China Department of Pharmaceutics, Shenyang Pharmaceutical University State Key Laboratory of Surface Physics and Department of Physics, Fudan University, 220 Handan Road, Shanghai, 200433, China; Laboratoire de Biochimie Théorique, UPR 9080 CNRS, Institut de Biologie Physico-Chimique et Université Paris Diderot, Paris 7, 13 rue Pierre et Marie Curie, 75005 Paris, France Department of Otolaryngology Head & Neck Surgery The First Hospital Jinzhou Medical University Jinzhou 121001 Liaoning China Department of Dermatology Jiangsu Province Hospital and Nanjing Medical University First Affiliated Hospital Nanjing China Department of Gastroenterology, Liaocheng People’s Hospital, Liaocheng 252000, China School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, Peoples Republic of China School of Pharmacy, Institutes of Integrative Medicine, Fudan University, Shanghai, China Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education and School of Pharmaceutical Sciences, Wuhan University, Wuhan, China Key Laboratory of Animal Virology of Ministry of Agriculture College of Animal Sciences Zhejiang University Hangzhou 310058 China Department of Dermatology and Venereology The Third Affiliated Hospital of Southern Medical University Guangzhou China; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases Guangzhou China Beijing Key Laboratory of Bioelectromagnetism Institute of Electrical Engineering Chinese Academy of Sciences Beijing P.R. China Henan Normal University Department of Chemistry, , Xin Xiang, Henan 453002, People’s Republic of China Neuroscience Center of Excellence, Louisiana State University Health Sciences Center Department of Neurology PLA Rocket Force Characteristic Medical Center Beijing China Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, P.R. China Soft Matter and Functional Materials, Helmholtz-Zentrum Berlin für Materialien und Energie, 14109 Berlin, Germany; Institute of Chemistry, University of Potsdam, 14467 Potsdam, Germany Department of Biological Sciences, Western Michigan University, Kalamazoo, MI, USA Shanghai Clinical Center for Endocrine and Metabolic Diseases (J.J., N.L., X.W., Y.L., Y.B., W.W., X.L., G.N.), E-Institute of Shanghai Universities, Shanghai 200025, China Center for Experimental Therapeutics and Reperfusion Injury, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115 Department of Gynecologic Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, China PCFM Lab and GDHPRC Lab School of Chemistry Sun Yat‐sen University Guangzhou 510006 P. R. China Soft Matter and Functional Materials, Helmholtz-Zentrum Berlin für Materialien und Energie, Hahn-Meitner-Platz 1, D-14109 Berlin, Germany Hainan Provincial Key Laboratory of Carcinogenesis and Intervention, Hainan Medical College, Haikou, PR.China; Key Laboratory of Molecular Biology, Hainan Medical College, Haikou, PR.China Department of Ophthalmology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China Department of Rheumatology, Jiangsu Province Hospital of Chinese Medicine Department of Botany (Y.L., T.D.S.) and Department of Biochemistry (J.P.G.), University of Wisconsin, Madison, Wisconsin 53706 Changchun University of Chinese Medicine, Changchun, Jilin Province, China Department of Chemical Biology and Theraputics, St. Jude Children’s Research Hospital, Memphis, Tennessee 38105 United States Beijing Zoo, Beijing, China School of Pharmacy, Institutes of Integrative Medicine, Fudan University, Shanghai, Peopleʼs Republic of China Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, 20032 Shanghai, People’s Republic of China;; Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, Fudan University, 20032 Shanghai, People’s Republic of China; Department of Pathology, Hospital of Beihang University, Beijing 100191, China. Department of Dermatology, Jiangsu Province Hospital, The First Affiliated Hospital of Nanjing Medical University, Nanjing, People’s Republic of China Department of Pharmacology; Jinling Hospital; Medical School of Nanjing University; Nanjing 210002; China National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, Shanghai 200025, China. 2Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China Department of Gastroenterology Children's Hospital of Nanjing Medical University Nanjing China Department of pharmacy, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China Department of Gynecologic Oncology, Women’s Hospital School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China; Institute for Translational Medicine School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China Physikalische Chemie I, Universität Bayreuth, Universitätsstrasse 30, 95440 Bayreuth, Germany Department of Chronic Disease Prevention and Control Suzhou City Centre for Disease Control and Prevention Suzhou China Soft Matter and Functional Materials, Helmholtz-Zentrum Berlin für Materialien und Energie, Hahn-Meitner-Platz 1, 14109 Berlin, Germany Authors' Affiliations: 1Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri and 2Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland Department of Physics and Institute of Materials Science and Engineering, Washington University, St. Louis, St. Louis, Missouri 63130, United States; Department of Physics, Nanchang University, Nanchang 330031, China Department of Food Science & Human Nutrition, University of Florida, Gainesville, FL From the Experimental Interventional Laboratory, Department of Cardiovascular Medicine (Z.Z., K.W., M.S.P., F.F., X.Z., A.M.L., E.J.T.), Cleveland Clinic Foundation, Cleveland, Ohio; Mid American Heart Institute (S.P.M.), Saint Luke’s Hospital, Kansas City, Mo; Borgess Hospital Research Institute (M.A.L.), Kalamazoo, Mich; and Columbia University (W.Q., Y.L., A.M.S., D.M.S.), College of Physician and Surgeons, New York, NY. Department of Dermatology Jiangsu Province Hospital The First Affiliated Hospital of Nanjing Medical University Nanjing China Department of Urology Teikyo University School of Medicine 2‐11‐1 Kaga, Itabashi‐ku Tokyo Japan Department of Biochemistry and Molecular Biology, Michigan State University, East Lansing, Michigan 48824 Department of Pathophysiology, Anhui Medical University, Hefei 230032, China Xinjiang Institute of Ecology and Geography, Chinese Academy of Sciences, Urumqi 830011, China. [email protected] Departments of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, Michigan, United States Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Key Laboratory of Endocrine Tumor, Shanghai Institute of Endocrinology and Metabolism, RuiJin Hospital, Shanghai Jiao Tong University School of Medicine, 197 RuiJin 2nd Road, Shanghai 200025, China. Department of Physics; Nanchang University; Nanchang 330031; P. R. China Department of Experimental Acupuncture Science, College of Acumox and Tuina, Shandong University of Traditional Chinese Medicine, Changqing District, Jinan, Shandong, China Institute of Chemistry University of Potsdam 14476 Potsdam Germany; Institute of Electrochemical Energy Storage Helmholtz‐Zentrum Berlin für Materialien und Energie 14109 Berlin Germany Fudan University 1 Department of Physics and Surface Physics Laboratory (National Key Laboratory), , 220 Handan Road, Shanghai 200433, China Hainan Provincial Key Laboratory of Carcinogenesis and Intervention, Hainan Medical College, Haikou, Hainan 571199, P. R. China; Key Laboratory of Molecular Biology, Hainan Medical College, Haikou, Hainan 571199, P. R. China Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, United States Shenzhen Major Infectious Disease Control Key Laboratory, Shenzhen Center for Disease Control and Prevention, Guangdong Province, People's Republic of China. Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences (Nanjing Botanical Garden Memorial Sun Yat-Sen), Nanjing 210014, China Department of Anesthesiology and Perioperative Medicine, Xijing Hospital Fourth Military Medical University Xi'an Shaanxi Province China Department of Pediatrics The Second Hospital of Hebei Medical University Shijiazhuang Hebei China Madison, Wisconsin 1Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri; Department of Cardiology, Affiliated Hospital of Southwest Jiaotong University, The Third People’s Hospital of Chengdu , Chengdu, Sichuan, China; Department of Geriatrics, North Sichuan Medical College , Nanchong, Sichuan, China Soft Matter and Functional Materials, Helmholtz-Zentrum Berlin für Materialien und Energie GmbH, Hahn-Meitner-Platz 1, 14109 Berlin, Germany Department of Pathology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Avenue, Changchun 130021, China From the Department of Neurology (L.D., H.C., Y.L., Y.D.), Xuanwu Hospital, Capital Medical University, Beijing, China; and Department of Neurology and Neuromuscular Research Laboratory (L.D., D.S., A.G.E., X.-M.S.), Mayo Clinic, Rochester, MN. Institute for Soft Matter and Functional Materials, Helmholtz-Zentrum Berlin für Materialien und Energie GmbH, Hahn-Meitner-Platz 1, D-14109 Berlin, Germany Institute of Sericulture and Apiculture College of Animal Sciences, Zhejiang University Hangzhou P. R. China Department of Pharmacy, Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, P. R. China Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, Florida;; Physiology and Biophysics and Institute of Advanced Synthesis (IAS), and School of Chemistry and Molecular Engineering Jiangsu National Synergetic Innovation Centre for Advanced Materials Nanjing Tech University Nanjing 211816 P. R. China *Department of Immunology, Graduate School of Medicine and Faculty of Medicine, University of Tokyo, Tokyo 113-0033, Japan; and Key Laboratory of Neurology of Hebei Province The Second Hospital of Hebei Medical University Shijiazhuang Hebei PR China Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, NMPA Key Laboratory for Research and Evaluation of Tissue Engineering Technology Products, Co‐innovation Center of Neuroregeneration Nantong University Nantong China Department of Neurology Xinxiang Central Hospital Xinxiang Henan province China 6SurExam Bio-Tech, Guangzhou Technology Innovation Base, Science City, Guangzhou, Guangdong Province, China. Department of Neurology, The PLA Rocket Force Characteristic Medical Center , Beijing , China Key Laboratory of Development and Evaluation of Chemical and Herbal Drugs for Animal Use, College of Veterinary Medicine, China Agricultural University, Beijing, China.; College of Animal Science and Technology, Beijing University of Agriculture, Beijing, China. Soft Matter and Functional Materials, Helmholtz-Zentrum Berlin für Materialien und Energie, Hahn-Meitner-Platz 1, 14109 Berlin, Germany; Institute of Chemistry, University of Potsdam, 14476 Potsdam, Germany State Key Laboratory of Genetic Engineering, Center for Evolutionary Biology, Collaborative Innovation Center of Genetics and Development, School of Life Sciences, Fudan University , Shanghai 200438 , China F−I2 Soft Matter and Functional Materials, Helmholtz-Zentrum Berlin für Materialien und Energie, Hahn-Meitner-Platz 1, 14109 Berlin, Germany Department of Gastrointestinal Surgery, Shunde Hospital, Southern Medical University, Shunde, Foshan, Guangdong Province 528300, China; China-American Cancer Research Institute, Dongguan Scientific Research Center, Guangdong Medical University, Dongguan, Guangdong Province 523808, China Outpatient Department of PLA 306th Hospital Aerospace Town Branch Beijing 100193 China Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, People’s Republic of China College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 215123 Suzhou, P. R. China Department of Clinical Laboratory San Ai Tang Hospital 74 Jing‐Ning Road Lanzhou 730030 China College of Physics and Electronic Engineering Northwest Normal University Lanzhou China Department of Gastroenterology, Liaocheng People’s Hospital, Liaocheng, China Authors' Affiliations: 1Cancer Prevention Fellowship Program, Nutritional Science Research Group; 2Chemopreventive Agent Development Research Group, Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland; Departments of 3Surgery and 4Genetics, University of Alabama at Birmingham, Birmingham, Alabama; 5Hormel Institute, Austin, Minnesota; 6Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin; and 7Eicosanoid Core Laboratory, Division of Clinical Pharmacology, Vanderbilt School of Medicine, Nashville, Tennessee School of Transportation Engineering, Jiangsu Shipping College, Nantong 226010, China Department of Epidemiology and Biostatistics, School of Public Health, Nanjing Medical University, Nanjing 210029, China. The First Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, China for the 23andMe Research Team, China Kadoorie Biobank Collaborative Group, and Major Depressive Disorder Working Group of the Psychiatric Genomics Consortium School of Biotechnology and Food Engineering, Changshu Institute of Technology, Changshu, Jiangsu 215500, China Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu 610064, China School of Electronic and Information Engineering, Lanzhou Jiaotong University, Lanzhou 730070, China Institute of Advanced Synthesis School of Chemistry and Molecular Engineering Jiangsu National Synergetic Innovation Center for Advanced Materials Nanjing Tech University Nanjing 211816 P. R. China Department of Ophthalmology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu Province, China. School of Pharmacy, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China; College of Horticulture and Landscape Architecture, Southwest University, Chongqing 400716, China; Key Laboratory of Horticulture Science for Southern Mountainous Regions, Ministry of Education, Chongqing 400715, China Soft Matter and Functional Materials, Helmholtz-Zentrum Berlin für Materialien und Energie, 14109 Berlin, Germany Columbia University Medical Center, New York, NY, USA Authors' Affiliations: 1Washington University School of Medicine, St. Louis, Missouri; 2Mayo Clinic, Rochester, Minnesota; 3M.D. Anderson Cancer Center, Houston, Texas; 4Karmanos Cancer Institute, Detroit, Michigan; 5University of Cincinnati, Cincinnati, Ohio; 6University of Texas Southwestern Medical Center, Dallas, Texas; 7University of Toledo College of Medicine, Toledo, Ohio; 8Louisiana State University Health Science Center, New Orleans, Louisiana; 9National Cancer Institute, Bethesda, Maryland; and 10National Human Genome Research Institute, Baltimore, Maryland Hainan Provincial Key Laboratory of Carcinogenesis and Intervention Hainan Medical College Haikou Hainan Province China; Key Laboratory of Molecular Biology Hainan Medical College Haikou Hainan Province China Department of Chemistry, University of Southern California, Los Angeles, CA 90089, USA and 2Department of Biological Sciences, University of Southern California, Los Angeles, CA 90089, USA State Key Laboratory of Genetic Engineering, Center for Evolutionary Biology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital , Nanjing 210029, China †Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115 Neuroscience Center of Excellence Louisiana State University Health Sciences Center New Orleans Louisiana USA Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, P.R. China Department of Urology, Juntendo University, Graduate School of Medicine, Tokyo, Japan Department of Neurology, Xuanwu Hospital Capital Medical University Beijing China Department of Gynecological Oncology, Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi 530000, P.R. China Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi; and The North Hospital of the Ninth People's Hospital of Shanghai City Shanghai 201999 China Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Research Centre, University of Manitoba, Winnipeg, Manitoba, Canada.; Faculty of Pharmacy, University of Manitoba, Winnipeg, Manitoba, Canada. Academy of Integrative Medicine, Fuzhou, Fujian 350122, China; Chen Keji Academic Thought Inheritance Studio, Fuzhou, Fujian 350122, China; Fujian Key Laboratory of Integrative Medicine on Geriatrics, Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350122, China Key Laboratory of Metallurgical Equipment and Control Technology Wuhan University of Science and Technology, Wuhan 430081, China; Precision Manufacturing Research Institute Wuhan University of Science and Technology, Wuhan 430081, China State Key Laboratory of Genetic Engineering, Center for Evolutionary Biology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University , Shanghai , China Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing 210028, Jiangsu Province, P.R. China; Laboratory of Translational Medicine, Jiangsu Province Academy of Traditional Chinese Medicine, Nanjing 210028, Jiangsu Province, P.R. China Department of Neurology, PLA Rocket Force General Hospital, No. 16 Xinjiekouwai Street, Beijing 100088, China The Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education,Department of Endocrinology and Metabolism,Zhongshan Hospital,Fudan University,Shanghai,People’s Republic of China Department of Cardiology, Affiliated Hospital of Southwest Jiaotong University, The Third People’s Hospital of Chengdu , Chengdu, Sichuan 610031, China; Department of geriatrics, North Sichuan Medical College , Nanchong, Sichuan 637000, China School of Life Science, Shandong University, Qingdao 266000, China Department of Physics, Washington University in St Louis, St. Louis, Missouri 63130, United States; Department of Physics, Nanchang University, Nanchang 330031, People’s Republic of China Central Operating Room, The First People's Hospital of Baiyin Baiyin 730900, Gansu, China. Department of Clinical Immunology, The Third Affiliated Hospital of Sun Yat-sen University , Guangzhou, China Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York, USA Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, P. R. China Departments of Surgery, Ophthalmology, Pathology, Neurology, and Physiology & Cellular Biophysics, College of Physicians & SurgeonsColumbia UniversityNew YorkNew York10032 Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin–Madison, 600 Highland Avenue, Madison WI 53792 Hainan Provincial Key Laboratory of Carcinogenesis and Intervention, Hainan Medical College, Haikou 571199, Hainan Province, P.R. China; Key Laboratory of Molecular Biology, Hainan Medical College, Haikou 571199, P.R. China College of Chemistry; Chemical Engineering and Materials Science; Soochow University; Suzhou 215123; China Department of Gastroenterology, Liaocheng People's Hospital Liaocheng 252000, China. Department of Anesthesiology, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China; Department of Anesthesiology, Affiliated Hospital of Chengde Medical College, Chengde 067000, China Institute for Clinical Evaluative Sciences Toronto ON Canada School of Physics and Materials Science; Anhui University; Hefei 230601; P. R. China National Research Center of Engineering and Technology for Utilization of Botanical Functional Ingredients from Botanicals, Hunan Agricultural University, Changsha 410128, China Institute of Sericulture and Apiculture College of Animal Sciences, Zhejiang University Hangzhou People's Republic of China Department of Cardiology The First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu China State Key Laboratory of Tree Genetics and Breeding, Key Laboratory of Silviculture of the National Forestry and Grassland Administration, Research Institute of Forestry, Chinese Academy of Forestry, Beijing 100091, China Department of Dermatology and VenereologyThe Third Affiliated Hospital of Southern Medical University Guangzhou China From the Division of Surgical Science, Department of Surgery, Columbia University Medical Center, New York, NY. Department of Orthopaedics, the 187th Hospital of Chinese PLA, Haikou, Hainan, PR China. Department of Pain Medicine, Xijing Hospital, Fourth Military Medical University, Xian, China State Key Laboratory of Genetic Engineering, Human Phenome Institute, Zhangjiang Fudan International Innovation Center, Center for Evolutionary Biology, School of Life Sciences, Fudan University , Shanghai , China NCDs Prevention and Control Department, Suzhou CDC, Suzhou, Jiangsu, China. Department of Hematology, Tongji Hospital Tongji University School of Medicine Shanghai China Department of Comprehensive Treatment, Hunan Province Maternal and Child Health Hospital, Changsha 410008,China. Henan Key Laboratory of Intelligent Manufacturing of Mechanical Equipment, Zhengzhou University of Light Industry, Zhengzhou 450002, China Zhejiang University School of Medicine Department of Biochemistry and Molecular Biology, State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, School of Basic Medicine, Peking Union Medical College, Beijing 100005, China. Physikalische Chemie I, University of Bayreuth, 95440 Bayreuth, Germany; F-I2 Soft Matter and Functional Materials, Helmholtz-Zentrum Berlin, Glienicker Str. 100, 14109 Berlin, Germany Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province, Women’s Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China School of Chemical and Environmental Engineering, Shanghai Institute of Technology, 100 Haiquan Road, Shanghai 201418, China Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China, and The Life Sciences Institute, Shandong Normal University, Jinan, Shandong 250014, China Guangdong Medical University, Dongguan, Guangdong Province, China; GCP Center, Shunde Hospital, Southern Medical University (The First People’s Hospital of Shunde Foshan), Foshan, Guangdong Province, China Emergency Department, Xiyuan Hospital, Beijing, China Division of Nephrology, Department of Medicine, University of Alabama at Birmingham, AL, USA SurExam Bio-Tech, Guangzhou Technology Innovation Base, Guangzhou, P.R. China Center for Mitochondria and Healthy Aging, School of Life Science Institute of Sericulture and Apiculture, College of Animal Sciences Zhejiang University Hangzhou 310058 China Physikalische Chemie I, University of Bayreuth, 95440 Bayreuth, Germany Department of Pharmacognosy, School of Pharmacy Fudan University Shanghai P.R. China State Key Laboratory of Pharmaceutical Biotechnology and Model Animal Research Center (MARC), Nanjing University, Nanjing 210023, China School of Cyber Science and Engineering, Southeast University, Nanjing 210096, Jiangsu, China Hongyashan State-Owned Forest Farm, Baoding 074200, China F−I2 Soft Matter and Functional Materials, Helmholtz-Zentrum Berlin, Glienicker Strasse 100, 14109 Berlin, Germany Department of Urology Graduate School of Medicine Juntendo University Tokyo Japan From the Division of Surgical Science, Department of Surgery (L.G.B., T.W., W.Q., Y.L., L.R., M.T.G., B.M., T.K., D.C.L., Y.K., D.M.S., A.M.S.); Department of Physiology & Cellular Biophysics (D.M.S.), College of Physicians & Surgeons; and Division of Periodontics, School of Dental & Oral Surgery (E.L.), Columbia University, New York, NY. Department of Bacteriology, National Institute of Infectious Diseases, Toyama 1-23-1, Shinjuku-ku, Tokyo 162-8640, Japan College of Acu-moxibustion and Massage, Shandong University of Chinese Medicine, Jinan 250355, China. Department of Dermatology Jiangsu Province People’s Hospital and Nanjing Medical University First Affiliated Hospital Nanjing China Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, Florida;; Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi; From the Division of Periodontics, School of Dental and Oral Surgery (E.L., I.B.L., A.P.J., S.T., P.N.P.), and Division of Surgical Science, Department of Surgery, College of Physicians and Surgeons (M.A.H., L.B., Y.L., A.M.S.), Columbia University, New York, NY. Department of Endocrinology and MetabolismAffiliated Zhongshan HospitalFudan UniversityShanghaiChina; Fudan Institute for Metabolic DiseasesShanghaiChina Department of Cardiology, The First Hospital of Shanxi Medical University Taiyuan 030001, P. R. China. Key Laboratory of Animal Virology of Ministry of Agriculture College of Animal Sciences Zhejiang University Hangzhou P. R. China Freie Universität Berlin, Department for Chemistry and Biochemistry, Fabeckstr. 34/36, Berlin, Germany College of Animal Science; Jilin University; Changchun; P. R. China Neuroscience Center of Excellence, School of Medicine, L.S.U. Health, New Orleans, LA 70112, USA From the Department of Pain Medicine, Xijing Hospital, Fourth Military Medical University, Xian, China (Q.W., X.Z., X.H., S.D., Z.J., P.L., C.L., N.G., Y.L.); and the Zhejiang Key Laboratory of Organ Development and Regeneration, Institute of Life Sciences, Hangzhou Normal University, Hangzhou, China (L.Q.). iHuman Institute, ShanghaiTech University, Shanghai 201210, China; School of Life Science and Technology, ShanghaiTech University, Shanghai 201210, China; University of Chinese Academy of Sciences, Beijing 100049, China Department of Chronic disease Prevention and Control, Suzhou Center for Disease Control and Prevention, Suzhou, China Internet Media Group, Microsoft Research Asia, Bejing, Beijing, China, 100191 (e-mail: [email protected]) Department of Comprehensive Surgery General Hospital of Chinese People's Liberation Army & National Clinical Research Center for Geriatric Disease Beijing China Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province, Women’s Reproductive Health Key Laboratory of Zhejiang Province, Department of Gynecologic Oncology, Women’s Hospital and Institute of Translational Medicine, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, China; State Key Laboratory of Genetic Engineering, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University, Shanghai, China College of Horticulture and Plant Protection, Yangzhou University, Yangzhou, China; Instrumental Analysis Center, Yangzhou University, Yangzhou, China Department of Mathematics and Statistics University of New Mexico Albuquerque New Mexico United States of America Department of Chemical & Biological Engineering, Monash University, Clayton, Victoria 3800, Australia State Key Laboratory of Marine Resource Utilization in South China Sea; Hainan University; Haikou 570228; China Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin Systems Integration Division, National Institute of Standards and Technology, 100 Bureau Drive, MS 8260, Gaithersburg, MD 20899 School of Biotechnology, East China University of Science and Technology, Shanghai 200237, China. Center for Epidemiology & Healthcare Delivery Research, JPS Health Network , Fort Worth, TX , USA School of Life Science; Shandong University; Qingdao; China State Key Laboratory of Genetic Engineering, Center for Evolutionary Biology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University , Shanghai 200438 , China; Human Phenome Institute, Zhangjiang Fudan International Innovation Center, and Ministry of Education Key Laboratory of Contemporary Anthropology, Fudan University , Shanghai 201203 , China Department of Pain Medicine, Xijing Hospital, The Fourth Military Medical University, Xi'an, China Center for Uterine Cancer Diagnosis and Therapy Research of Zhejiang Province, Women's Reproductive Health Key Laboratory of Zhejiang Province, Women's Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China Key Laboratory of Computational Biology, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nu-trition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China University of Colorado Anschutz Medical Campus, School of Medicine, Department of Dermatology, Aurora, CO 80045, USA Department of Pharmacy, Shandong Cancer Hospital and Institute, Shandong First Medical University and Shandong Academy of Medical Sciences, No. 440 Jiyan Road, Jinan 250117, Shandong, China Hainan Provincial Key Laboratory of Carcinogenesis and Intervention Hainan Medical College Haikou Hainan Province 571199 People's Republic of China; Key Laboratory of Molecular Biology Hainan Medical College Haikou 571199 People's Republic of China College of Chemistry Chemical Engineering and Materials Science Soochow University Suzhou 215123 P. R. China 2Department of Medicine, Division of Hematology/Oncology, Columbia University Medical Center/New York Presbyterian, New York, New York. Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, Mississippi; Department of Neurology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China State Key Laboratory of Pharmaceutical Biotechnology and Model Animal Research Center (MARC) of Nanjing University Nanjing University Nanjing China Hainan Provincial Key Laboratory of Carcinogenesis and Intervention, Hainan Medical College, Haikou 571199, Hainan Province, PR China; Key Laboratory of Molecular Biology, Hainan Medical College, Haikou 571199, PR China Department of Botany (Y.L., T.D.S.), Department of Biochemistry (J.M.S.), and Department of Plant Pathology (J.Y.), University of Wisconsin, Madison, Wisconsin 53706 College of Textile and Clothing Engineering, Soochow University, Suzhou 215123, China Department of Biochemistry and Molecular Biology, State Key Laboratory of Common Mechanism Research for Major Diseases, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College Key Laboratory of Biomaterials and Nanotechnology for Cancer Immunotherapy The Tianjin Key Laboratory of Biomaterials Institute of Biomedical Engineering Peking Union Medical College & Chinese Academy of Medical Sciences 236# Baidi Road, Nankai District Tianjin 300192 China Department of Anesthesiology, Shanghai First Maternity and Infant Hospital, Tongji University School of Medicine, Shanghai 201204, China 1Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri and Department of Neurology, Xuanwu Hospital, Capital Medical University, Beijing, China Department for Electrochemical Energy Storage Helmholtz‐Zentrum Berlin für Materialien und Energie Hahn‐Meitner‐Platz 1 Berlin Germany; Institute of Chemistry University of Potsdam Potsdam Germany Department of Cardiology, First Hospital of Shanxi Medical University, Taiyuan, China Research fellow, Geriatric Anesthesia Research Unit, Department of Anesthesia, Critical Care and Pain Medicine, Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, and Associate Professor, Key Laboratory of Health Ministry in Congenital Malformation, The Affiliated Shengjing Hospital of China Medical Uni Department of Nephrology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai, China Department of Endocrinology and Metabolism, Zhongshan Hospital Fudan Univeristy Shanghai China Department of Physics, Nanchang University, Nanchang 330031, China From the Aab Cardiovascular Research Institute (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk) and Department of Medicine (K.S., P.N., A.Z., N.N.S., F.J., M.O., M.R.O., Z.C., P.M., Y.L., A.M., C.Y., B.C. Blaxall, B.C. Berk), University of Rochester School of Medicine and Dentistry, Rochester, NY; Department of Cardiovascular Medicine, Tohoku University Graduate School of Medicine, Aoba-ku, Sendai, Japan (K.S.). Key Laboratory of Health Ministry in Congenital Malformation Affiliated Shengjing Hospital of China Medical University Shenyang China Department of Endocrinology, Fudan Institute for Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai 200032, China School of Physical Science and Technology ShanghaiTech University Shanghai 201210 China Department of Laboratory Medicine, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai, China Department of Endocrinology and Metabolism, Zhongshan Hospital, Key Laboratory of Metabolism and Molecular Medicine, the Ministry of Education, Fudan University, Shanghai, China Hainan Provincial Key Laboratory of Carcinogenesis and Intervention Hainan Medical College Hainan Province Haikou PR. China; Key Laboratory of Molecular Biology Hainan Medical College Hainan Province Haikou PR. China Department of Cardiovasology, The First Hospital of Xi'an, Shaanxi, China; Department of Traditional Chinese Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China. Key Laboratory of Computational Biology, Bio-Med Big Data Center, CAS-MPG Partner Institute for Computational Biology, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai 200031, China; Collaborative Innovation Center of Genetics and Development, Shanghai 200438, China Department of Ophthalmology, Jinling Hospital, Nanjing University, PR China Authors' Affiliations: Departments of 1Physiology and the Cancer Center and 2Pharmacology and Toxicology and the Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin; and 3Department of Surgery and the Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri; Authors' Affiliations: Departments of 1Physiology and the Cancer Center and 2Pharmacology and Toxicology and the Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin; and 3Department of Surgery and the Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri School of Forensic Medicine, China Medical University, Shenyang, PR China;; Key Laboratory of Health Ministry in Congenital Malformation, the Affiliated Shengjing Hospital of China Medical University, Shenyang, PR China; National Research Center of Dairy Engineering and Technology, Green Food Research Institute of Heilongjiang, Northeast Agricultural University, Harbin 150086, China 4Department of Gynecologic Oncology, The Affiliated Women's Hospital and Institute for Translational Medicine, School of Medicine, Zhejiang University, Hangzhou, Zhejiang, China. Guangzhou Cord Blood Bank Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou Guangdong China Department of Dermatology and VenereologyThe 3rd Affiliated Hospital of Southern Medical University 183 West Zhongshan Rd, Guangzhou 510630 China Department of Rheumatology, Jiangsu Provincial Hospital of Traditional Chinese Medicine, Nanjing, China School of Traditional Chinese Materia Medica Shenyang Pharmaceutical University Shenyang Liaoning China Key Laboratory of Metabolism and Molecular Medicine, The Ministry of Education, Department of Endocrinology and Metabolism Zhongshan Hospital, Fudan University Shanghai China Department of Hematology, Wuxi People’s Hospital, Nanjing Medical University, Wuxi, Jiangsu, China; Department of Clinical Laboratory, Wuxi People’s Hospital, Nanjing Medical University, Wuxi, Jiangsu, China; Department of Hematology, Wuxi People’s Hospital, Nanjing Medical University, Wuxi, Jiangsu, China Department of Food Science & Human Nutrition, University of Florida, Gainesville, FL 32611; Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana. Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China State Key Laboratory for Superlattices and Microstructures, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China Authors' Affiliations: 1Greenebaum Cancer Center and 2Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland and 3Department of Oral and Maxillofacial Surgery, Shanghai Jiaotong University School of Medicine, Shanghai, People's Republic of China School of Mechanical and Resource Engineering, Wuzhou University, Wuzhou, Guangxi 543002, P. R. China Department of Ophthalmology, Xuan Wu Hospital, Capital Medical University, Beijing, China Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, 210029, P.R. China State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China. Department of Anaesthesiology Guangdong Medical College Zhanjiang China Department of Dermatovenerology, Jiangsu Provincial People's Hospital / The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China. The Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education Department of Endocrinology and Metabolism Fudan Institute for Metabolic Diseases Zhongshan Hospital Fudan University Shanghai 230032 P. R. China Authors' Affiliations: 1Washington University, St. Louis, Missouri; 2Karmanos Cancer Institute, Detroit, Michigan; 3University of Cincinnati, Cincinnati, Ohio; 4Mayo Clinic, Rochester, Minnesota; 5University of Texas Southwestern Medical Center, Dallas, Texas; 6University of Toledo College of Medicine, Toledo, Ohio; 7Louisiana State University Health Science Center, New Orleans, Louisiana; 8National Cancer Institute, Bethesda, Maryland; 9National Human Genome Research Institute, Baltimore, Maryland; and 10M. D. Anderson Cancer Center, Houston, Texas EM-ISFM Institute of Soft Matter and Functional Materials; Helmholtz-Zentrum Berlin für Materialien und Energie; 14109 Berlin; Germany Department of Ophthalmology, Nanjing General Hospital of Nanjing Military Command PLA, Nanjing 210002, China. School of Urban and Environmental Science, Huaiyin Normal University, Huai’an 223300, China Department of Laboratory Medicine, Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital, Shanghai 201318, P.R. China Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, 300 Guangzhou Road, Nanjing 210029, PR China Department of Chemistry, Henna Normal University, Xinxian, People's Republic of China Institute of Soft Matter and Functional Materials, Helmholtz Zentrum Berlin für Materialien und Energie, Hahn-Meitner-Platz 1, 14109 Berlin, Germany; Institute of Chemistry, University of Potsdam, 14476 Potsdam, Germany Department of Otolaryngology Head and Neck Surgery The First Hospital Jinzhou Medical University Jinzhou 121001 Liaoning P. R. China Institute of Metabolism and Regenerative Medicine, Shanghai Sixth People’s Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200233, China Soft Matter and Functional Materials; Helmholtz-Zentrum Berlin für Materialien und Energie; 14109 Berlin; Germany Comparative Orthopaedic Research Laboratory School of Veterinary Medicine, University of Wisconsin‐Madison 2015 Linden Drive Madison Wisconsin 53706 Institut für Chemie und Biochemie – Anorganische Chemie Freie Universität Berlin Fabeckstrasse 34–36 14195 Berlin Germany Research Fellow, Department of Anesthesia, Critical Care and Pain Medicine, Genetics and Aging Research Unit, MassGeneral Institute for Neurodegenerative Disease, Massachusetts General Hospital and Harvard Medical School, and Associate Professor, Key Laboratory of Health Ministry in Congenital Malformation, Affiliated Shengjing Hospital of China Medical University, Shenyang, Liaoning, P. R. China Department of Anatomy, Comparative Medicine Institution, Medical School of Nantong University, Nantong 226001, Jiangsu Province, China Department of Physiology, Basic Medical College, Jiamusi University, Jiamusi, Heilongjiang 154007, P.R. China Department of Physics; Nanchang University; Nanchang 330031; People's Republic of China Department of pharmacy, Affiliated Hospital of Nanjing University of Chinese Medicine Department of Pharmacognosy School of Pharmacy Fudan University Shanghai 201203 P. R. China Soft Matter and Functional Materials; Helmholtz-Zentrum Berlin für Materialien und Energie GmbH; 14109 Berlin Department of Prenatal Diagnostic center, Guangzhou Women and Children's Medical Center Guangzhou Medical University Guangzhou China Department of Endocrinology Huadong Hospital Affiliated to Fudan University Shanghai PR China; The Shanghai Key Laboratory of Clinical Geriatric Medicine Shanghai PR China Department of Cardiology, Institute of Cardiovascular Diseases, First Affiliated Hospital of Dalian Medical University School of Biological Science and Engineering, South China University of Technology, Guangzhou 510006, China Department of Dermatology, First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu 210029, China. [email protected] Natural Products Research Laboratories, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599-7568, United States Center of Nanoelectronics, School of Microelectronics Shandong University Jinan 250100 P. R. China; State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Science Shanghai 200050 P. R. China Department of Chemical Biology and Therapeutics, St. Jude Children’s Research Hospital, 262 Danny Thomas Place, Mail Stop 1000, Memphis, Tennessee 38105, United States From the Ophthalmology and Neuroscience Center, Louisiana State University Health Sciences Center, New Orleans, Louisiana. Analysis and test center, Co-Innovation Center for Modern Production Technology of Grain Crops, Yangzhou University, Yangzhou, China 5 Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China School of Machinery and Automation, Wuhan University of Science and Technology, Wuhan 430070, China Suzhou Center for Disease Prevention and Control, Suzhou 215007, China National Engineering Research Center for Biomaterials; Sichuan University; Chengdu 610064; China State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter (FJIRSM), Chinese Academy of Sciences (CAS), Fuzhou 350002, China; University of Chinese Academy of Sciences, Beijing 100049, China Systems Integration Division, National Institute of Standards and Technology 2 , 100 Bureau Dr., Gaithersburg, MD20899, USA Department of Oral and Maxillofacial Surgery College of Stomatology Ninth People's Hospital Shanghai Jiao Tong University School of Medicine Shanghai China; Shanghai Key Laboratory of Stomatology Shanghai China Key Laboratory of Green Chemistry & Technology Ministry of Education College of Chemistry Sichuan University Chengdu 610064 China Graduate School of Tianjin University of TCM, Tianjin 300193, China. Department of Gastroenterology, Children’s Hospital of Nanjing Medical University, Nanjing, Jiangsu, China. Center for Uterine Cancer Diagnosis & Therapy Research of Zhejiang Province , Women’s Reproductive Health Key Laboratory of Zhejiang Province and Department of Gynecologic Oncology, Women’s Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310029, China School of Pharmacy Lanzhou University Lanzhou 730000 China School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, P.R. China Department of Neurology, Xuanwu Hospital, Capital Medical University , Beijing, China SurExam Bio-Tech, Guangzhou Technology Innovation Base, Guangzhou, China Soft Matter and Functional Materials Helmholtz-Zentrum Berlin für Materialien und Energie 14109 Berlin Germany; Institute of Chemistry University of Potsdam 14476 Potsdam Germany Hubei Key Laboratory for Kidney Disease Pathogenesis and Intervention, Huangshi Cental Hospital of Edong Healthcare Group, Hubei Polytechnic University School of Medicine, Huangshi, Hubei, China; Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China College of Civil Engineering, Henan University of Engineering, Zhengzhou 451159, China Fudan University 1 State Key Laboratory of Surface Physics, Key Laboratory for Computational Physical Sciences (MOE), and Department of Physics, , 220 Handan Road, Shanghai 200433, China; Université Paris Diderot 2 Laboratoire de Biochimie Théorique, UPR 9080 CNRS, , Sorbonne Paris Cité, Institut de Biologie Physico Chimique, 13 rue Pierre et Marie Curie, 75005 Paris, France Department of Cell Biology and Medical Genetics, School of Medicine, Zhejiang University, Hangzhou, China Department of Dermatology The First Affiliated Hospital of Nanjing Medical University Nanjing Jiangsu China Department of Neurology, Nanjing Hospital of Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China Department of Surgical Sciences, School of Veterinary Medicine University of Wisconsin Madison Wisconsin USA Department of Anatomy, Comparative Medicine Institution, Medical School of Nantong University, Nantong, China School of Environmental Science and Engineering, Shanghai Jiao Tong University, Shanghai, 200240, China, Wadsworth Center, New York State Department of Health, and Department of Environmental Health Sciences, School of Public Health, State University of New York at Albany, Empire State Plaza, PO Box 509, Albany, New York 12201-0509, and International Joint Research Center for Persistent Toxic Substances, State Key Laboratory of Urban Water Resource and Environment, Harbin Institute of Technology, Harbin... School of Life Science Shandong University Qingdao China; Clinical Laboratory Medicine Department Jining No. 1 People's Hospital Jining China Department of Otolaryngology Head and Neck Surgery, Affiliated Fuzhou First Hospital of Fujian Medical University, Fujian, China; University of Colorado Anschutz Medical Campus, School of Medicine, Department of Dermatology, Aurora, CO, USA Department of Medicine, University of Alabama at Birmingham, Birmingham, Alabama From the Division of Endocrinology, New York University Langone Medical Center, New York, NY (S.V., R.A., X.S., R. Rosario, Y.L., A.M.S., R. Ramasamy); Division of Preventive Medicine and Nutrition (H.N., N.S., K.H., Y.H., S.Y., K.D., L.A.H., I.J.G.) and Pediatric Critical Care (T.R.), Columbia University, New York, NY. Key Laboratory of Crop Genetics and Physiology of Jiangsu Province, Key Laboratory of Plant Functional Genomics of the Ministry of Education, Yangzhou University, Yangzhou 225009, China College of Food Science and Engineering South China University of Technology Guangzhou 510640 China National Institute of Standards and Technology, Gaithersburg, MD Department of Chronic Disease Prevention and Control, Suzhou Center for Disease Control and Prevention, Suzhou, Jiangsu, China Department of Nephrology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine, Shanghai 200437, China Department of Chemistry and Biochemistry, Freie Universität Berlin, Fabeckstr. 34/36, 14195 Berlin, Germany Department of Communicable Diseases Control and Prevention, Shenzhen Center for Disease Control and Prevention, Shenzhen 518055, China Institute of Suzhou Biobank, Suzhou Center for Disease Prevention & Control, Suzhou, Jiangsu, China; Department of Occupational Disease Prevention, Jiangsu Provincial Center for Disease Control & Prevention, Nanjing, China Department of Cardiology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China Department of Orthopedics, Xinqiao Hospital, Third Military Medical University, Chongqing 400037, PR China. Key Laboratory of Metabolism and Molecular Medicine, Ministry of Education, and Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China Department of Dermatology The First Affiliated Hospital of Nanjing Medical University Nanjing China Department of Child Rehabilitation The Key Laboratory of Pathobiology, Ministry of Education, Department of Pathology, College of Basic Medical Sciences, Jilin University, 126 Xinmin Avenue, Changchun 130021, China State Key Laboratory of Genetic Engineering and Ministry of Education (MOE) Key Laboratory of Contemporary Anthropology, Collaborative Innovation Center for Genetics and Development, School of Life Sciences, Fudan University , Shanghai 200438, China Institute of Medical Information/Medical Library, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, China Laboratory of Invertebrate Pathology and Applied Microbiology, College of Biotechnology, Southwest University, Chongqing, China Beijing Key Laboratory of Captive Wildlife Technologies Beijing Zoo Beijing China Key Laboratory of Animal Epidemic Etiology and Immunological Prevention of Ministry of Agriculture College of Animal Sciences, Zhejiang University Hangzhou P. R. China Department of Cardiology First Affiliated Hospital of Dalian Medical University Dalian Liaoning Province China Food Science & Human Nutrition Department, University of Florida, Gainesville, Florida College of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007, China. [email protected] Department of Pediatric Ward Three, Shengli Oilfield Central Hospital, Dongying, China. Department of Cardiology, The First Hospital of Shanxi Medical University Taiyuan 030032, Shanxi, China. State Key Laboratory of Marine Resource Utilization in South China Sea, Hainan University, Haikou 570228, China Institute of Pharmacy, School of Pharmacy, Henan University, Kaifeng, China Department of Intensive Care Unit, The First People’s Hospital of Yinchuan City, Yinchuan, China Department of Ophthalmology Beijing Shijitan Hospital Capital Medical University Beijing China From the Departments of Pharmacology/Obstetrics and Gynecology (J.B., J.S., K.W., J.M., J.N.M., B.L.) and Physiology (R.L., Y.L.), University of Mississippi Medical Center, Jackson, MS; Experimental and Clinical Research Center and Max-Delbrück Center for Molecular Medicine and HELIOS Clinic-Berlin, Germany (G.W., F.H., R.D.). Clinical Laboratory, Dongyang People's Hospital 60 West Wuning Road, Dongyang 322100, Zhejiang, China. Shanghai Institute of Precision Medicine Shanghai Ninth People's Hospital Shanghai China Department of Dermatology and VenereologyThe 3rd Affiliated Hospital of Southern Medical University Guangzhou China; Guangdong Provincial Key Laboratory of Bone and Joint Degeneration Diseases Guangzhou China Department of Gastroenterology, Second Affiliated Hospital of Anhui Medical University, Hefei 230012, China Department of Surgery, Washington University School of Medicine, St. Louis, Missouri Molecular and Computational Biology Program, Departments of Biological Sciences, Chemistry, Physics and Astronomy, and Computer Science, University of Southern California, Los Angeles, CA 90089; State Key Laboratory of Tree Genetics and Breeding Research Institute of Forestry Chinese Academy of Forestry Beijing 100091 China Department of Ophthalmology, Beijing Shijitan Hospital, Capital Medical University, China, Beijing, China. CAS Key Laboratory of Materials for Energy Conversion Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. China; Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing 100049 P. R. China School of Veterinary Medicine, University of Wisconsin—Madison, 2015 Linden Drive, Madison, Wisconsin 53706, United States Department of Clinical Immunology The Third Affiliated Hospital of Sun Yat‐sen University Guangzhou Guangdong China Department of Cardiology The First Affiliated Hospital of Nanjing Medical University Nanjing China Department of Ophthalmology, Capital Medical University, Beijing, China. [email protected] School of Materials Science & Engineering, Tianjin University of Technology, Tianjin 300384, China, and School of Materials Science and Engineering, Institute of Information Functional Materials & Devices, Harbin Institute of Technology, Harbin 150001, China Department of Neurology, The Third Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China Department of Endocrinology, First Affiliated Hospital of Soochow University, Suzhou 215006, China Central Laboratory, Second Affiliated Hospital of China Medical University, Shenyang 110004, China. Department of Anesthesiology, Affiliated Hospital of Chengde Medical College, Chengde 067000, Hebei, China Shanghai Public Health Clinical Center, Fudan University, Shanghai, China Department of Biological Sciences Western Michigan University Kalamazoo MI USA Department of Geriatrics, Shanghai Sixth People's Hospital Affiliated with Shanghai Jiao Tong University School of Medicine , Shanghai, China Beijing Key Lab of Microstructure and Property of Advanced Material, Institute of Microstructure and Properties of Advanced Materials, Beijing University of Technology, Beijing 100124, China Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, Jiangsu, China. Center for Advancing Materials Performance from the Nanoscale, State Key Laboratory for Mechanical Behavior of Materials, Xi’an Jiaotong University, Xi’an 710049, People’s Republic of China; Department of Otorhinolaryngology, Huashan Hospital, Shanghai 200040, China. Center of Nanoelectronics School of Microelectronics Shandong University Jinan 250100 P. R. China Key Laboratory of Metabolism and Molecular Medicine of the Ministry of Education,Department of Biochemistry and Molecular Biology of School of Basic Medical Sciences and Department of Endocrinology and Metabolism of Zhongshan Hospital,Fudan University,Shanghai,China Department for Electrochemical Energy Storage, Helmholtz-Zentrum Berlin für Materialien und Energie, Hahn-Meitner-Platz 1, 14109 Berlin, Germany; Institute of Chemistry, University of Potsdam, 14476 Potsdam, Germany Center of Medical Physics and Technology Hefei Institutes of Physical Science, Chinese Academy of Sciences Hefei China Department of Gastroenterology, The Second Affiliated Hospital of Anhui Medical University, Hefei 230601, P.R. China Laboratory for Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing 100871, China, and Department of Plant, Soil and Insect Sciences, University of Massachusetts, Stockbridge Hall, Amherst, Massachusetts 01003-7245 Department of Urology, Juntendo University, Graduate School of Medicine, Tokyo 113-8421, Japan Institute of Translational Medicine, School of Medicine, Zhejiang University, China 1Department of Endocrinology and Metabolism, Fudan Institute of Metabolic Diseases, Zhongshan Hospital, Fudan University, Shanghai, China Institute of Advanced Synthesis; School of Chemistry and Molecular Engineering; Jiangsu Nation Synergetic Innovation Center for Advanced Materials; Nanjing Tech University; Nanjing 211816 Suzhou Center for Disease Control and Prevention, Suzhou, Jiangsu, China College of Acu-moxibustion and Tuina, Shandong University of Traditional Chinese Medicine, Jinan 250355, China. Department of Bacteriology, Faculty of Medicine, University of the Ryukyus, Nishihara, Okinawa 903-0215, Japan Jiangsu Key Laboratory of Crop Genomics and Molecular Breeding, State Key Laboratory of Hybrid Rice, Jiangsu Key Laboratory of Crop Genetics and Physiology, Yangzhou University, Yangzhou 225009, China Department of Rheumatology Affiliated Hospital of Nanjing University of Chinese Medicine Nanjing China; The First Clinical Medical College Nanjing University of Chinese Medicine Nanjing China Soft Matter and Functional Materials; Helmholtz-Zentrum Berlin fürMaterialien und Energie; 14109 Berlin; Germany University of Science and Technology of China Department of Chemical Physics, Hefei National Laboratory for Physical Sciences at the Microscale, , Hefei 230026, China Department of Applied Social Studies, City University of Hong Kong, Hong Kong College of Chemistry, Chemical Engineering and Materials Science Soochow University Suzhou 215123 China Department of Cardiology, the First Affiliated Hospital of Dalian Medical University, Dalian 2 , China ; Department of Gynecologic Oncology, The Affiliated Tumor Hospital of Guangxi Medical University, Nanning, Guangxi, China College of Acupuncture-moxibustion and Tuina, Shandong University of Traditional Chinese Medicine, Jinan 250355, China. Department of Anesthesiology Fudan University Shanghai Cancer Center Shanghai China; Department of Oncology, Shanghai Medical College Fudan University Shanghai China Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai, P. R. China Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana 70112, United States Department of Neurology, Xiyuan Hospital, China Academy of Chinese Medical Science, Beijing, China (mainland) Department of Neurology The PLA Rocket Force Characteristic Medical Center Beijing China State Key Laboratory of Superlattices and Microstructures; Institute of Semiconductors; Chinese Academy of Sciences; Beijing 100083, China Department of Dermatology, Xiangya Hospital Central South University Changsha China; Hunan Engineering Research Center of Skin Health and Disease Central South University Changsha China; Hunan Key Laboratory of Skin Cancer and Psoriasis Central South University Changsha China Department of Clinical laboratory, Gansu Provincial Hospital, Lanzhou, China iHuman Institute, ShanghaiTech University, 201210 Shanghai, China; School of Life Science and Technology, ShanghaiTech University, 201210 Shanghai, China; University of Chinese Academy of Sciences, 100049 Beijing, China Key Laboratory of Green Chemistry & Technology, Ministry of Education, College of Chemistry, Sichuan University, Chengdu, 610064, People’s Republic of China Soft Matter and Functional Materials, Helmholtz-Zentrum Berlin, Hahn-Meitner Platz 1, D-14109 Berlin, Germany Authors' Affiliations: 1Departments of Physiology and Pharmacology and the Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin; 2Breakthrough Breast Cancer Research, Institute for Cancer Research, London, United Kingdom; 3Department of Surgery, Washington University School of Medicine, St. Louis, Missouri; 4Hormel Institute, Austin, Minnesota; 5Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama; and 6Chemoprevention Agent Development Research Group, National Cancer Institute, Rockville, Maryland College of Animal Sciences Zhejiang University Hangzhou China From the Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa (J.S., L.W., J.W., J.Z., S.W., R.L.); State Key Laboratory of Cardiovascular Disease, National Center for Cardiovascular Diseases, Fuwai Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China (J.S.); and Department of Pharmacology and Medicine, University of Mississippi Medical Center, Jackson (F.F., Y.L., Y.F., L.A.J.). National Engineering Research Center for Biomaterials, Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan 610065, China The Key Laboratory of Pathology, Ministry of Education, College of Basic Medical Science Jilin University Changchun China State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics Chinese Academy of Sciences 1295 Dingxi Road Shanghai 200050 P. R. China Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States Department of Obstetrics and Gynecology, Affiliated Hospital of Integrated Traditional Chinese and Western Medicine, Nanjing University of Chinese Medicine, Nanjing, Jiangsu 210028, P.R. China The State Key Laboratory of Pharmaceutical Biotechnology Model Animal Research Center (MARC), Nanjing University Nanjing 210093 China g School of Chemistry and Environmental Science, Key Laboratory for Yellow River and Huai he River Water Environment and Pollution Control Ministry of Education, Henan Normal University, Xinxiang 453007, P. R. China Key Laboratory of Plant Functional Genomics of the Ministry of Education/Jiangsu Key Laboratory of Crop Genetics and Physiology/Co‐Innovation Center for Modern Production Technology of Grain Crops of Jiangsu Province Yangzhou University Yangzhou 225009 China Key Laboratory of Green Chemistry & Technology; Ministry of Education; College of Chemistry; Sichuan University; Chengdu 610064 Department of Municipal and Environmental Engineering, Harbin Institute of Technology, Harbin 150090, China. [email protected] The Department of Dermatology, Xiangya Hospital Central South University Changsha Hunan China; National Engineering Research Center of Personalized Diagnostic and Therapeutic Technology Changsha Hunan China; Furong Laboratory Changsha Hunan China; Hunan Key Laboratory of Skin Cancer and Psoriasis, Human Engineering Research Center of Skin Health and Disease Xiangya Hospital Changsha Hunan China; National Clinical Research Center for Geriatric Disorders Xiangya Hospital Changsha Hunan China 2Center for Outcomes Research, JPS Health Network, Fort Worth, Texas. College of Acu-moxibustion, Tuina, China. Center of Neuroscience Excellence, Louisiana State University Health Science Center, New Orleans, Louisiana Department of Laboratory Medicine, Zhoupu Hospital, Affiliated to Shanghai University of Medicine & Health Sciences, Shanghai 201318, China Soft Matter and Functional Materials, Helmholtz-Zentrum Berlin für Materialien und Energie GmbH, 14109 Berlin, Germany; Institute of Chemistry, University of Potsdam, 14467 Potsdam, Germany Center of Medical Physics and Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, No. 350 Shushanhu Road, Hefei 230031, China Shanghai Clinical Center for Endocrine and Metabolic Diseases, Shanghai Key Laboratory of Endocrine Tumor, Shanghai Institute of Endocrinology and Metabolism, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, 197 RuiJin 2nd Road, Shanghai 200025, China Division of Nephrology, Department of Medicine, Nephrology Research and Training Center, University of Alabama at Birmingham, Birmingham, Alabama From the Aab Cardiovascular Research Institute, University of Rochester, Rochester, NY (N.-T.L., Y.T., T.S., C.H.W., E.C., K.-S.H., H.L., Y.L., C. Morrell, M.O., C. McClain, C.Y., K.F., J.-i.A.); Faculty of Life Sciences, University of Manchester, Manchester, United Kingdom (X.W., C.T.); the Department of Biology and Molecular Biology, Montclair State University, Montclair, NJ (C.A.M.); Howard Hughes Medical Institute and Department of Cellular and Molecular Pharmacology, University of California,... Department of Immunology and National Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100005, China. Critical Care Services Ontario, University Health Network, Toronto, Ontario, Canada Institute of Electrochemical Energy Storage Helmholtz-Zentrum Berlin für Materialien und Energie Hahn-Meitner-Platz 1 14109 Berlin Germany Department of Natural Medicine, School of Pharmacy, Fudan University, Shanghai, 201203, China Department of Endocrinology and Metabolism Zhongshan Hospital Key Laboratory of Metabolism and Molecular Medicine the Ministry of Education Fudan University Shanghai China Division of Surgical ScienceDepartment of Surgery Columbia UniversityMedical Center New York New York USA Institute of Macromolecular Chemistry and Textile Chemistry, Dresden University of Technology, D-01062 Dresden, Germany, and Institute of Physical Chemistry and Electrochemistry, Dresden University of Technology, D-01062 Dresden, Germany Department of Dermatology the First Affiliated Hospital of Nanjing Medical University Nanjing China Department of Anesthesiology, Xijing Hospital, Fourth Military Medical University, Xi'an, China College of Chemistry; Chemical Engineering and Materials Science, Soochow University; Suzhou 215123; China 1State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing, China. School of Metallurgy and Environment Central South University Changsha 410083 P. R. China Department of Anesthesiology, Affiliated Hospital of Guangdong Medical University, Zhanjiang, Guangdong, 524001, China Department of Urology, Teikyo University School of Medicine, Tokyo, Japan. Department of Pediatrics the Second Hospital of Hebei Medical University, Shijiazhuang, Hebei 050000, China. [email protected]. Department of Surgery, College of Physicians and Surgeons Columbia University New York New York USA Key Laboratory of Southwest China Wildlife Resources Conservation (Ministry of Education), College of Life Sciences, China West Normal University, Nanchong, Sichuan 637009, P.R. China National Engineering Research Center for Biomaterials Sichuan University 29 Wangjiang Road Chengdu 610064 P. R. China; College of Biomedical Engineering Sichuan University 29 Wangjiang Road Chengdu 610064 P. R. China Department of Ophthalmology and Visual Sciences, Kellogg Eye Center, University of Michigan Medical School, Ann Arbor, MI 48105; and Division of Metabolism, Endocrinology, and Diabetes, Department of Internal Medicine, University of Michigan Medical School, Ann Arbor, MI 48105 Stranski-Laboratorium, Institut für Chemie, TU Berlin, Strasse des 17.Juni 124, 10623 Berlin, Germany, Physikalische Chemie I, Universität Bayreuth, Universitätsstrasse 30, 95440 Bayreuth, Germany, and Departamento de Quimica Fisica, and Unidad Asociada CSIC-Universidade de Vigo, 36310 Vigo, Spain Institute of Clinical Evaluative Sciences, Toronto ON. National Engineering Research Center for Biomaterials, Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan, 610065, China; College of Biomedical Engineering, Sichuan University, 29 Wangjiang Road, Chengdu, Sichuan, 610065, China School of Nursing, China Medical University, Shenyang City, Liaoning Province, People’s Republic of China Departments of Acupuncture and Tuina, Shandong University of Traditional Chinese Medicine Jinan 250355, China. Key Laboratory of Plant Functional Genomics of the Ministry of Education, Co-Innovation Center for Modern Production Technology of Grain Crops, College of Agriculture, Yangzhou University, Yangzhou 225009, China National Institutes for Food and Drug Control, Beijing, China Department of Anesthesiology, Affiliated Hospital of Chengde Medical University, Chengde, Hebei, China Department of Chinese Medicine, General Hospital of Tianjin Medical University, Tianjin 300052. Department of Research, Proteolix Inc, South San Francisco, CA; and Department of Clinical Laboratory, Gansu Provincial Hospital, Lanzhou 730000, China. [email protected]. School of Materials Science and Engineering, Henan University of Science and Technology, Luoyang 471023, China Jiangsu Key Laboratory for the Research and Utilization of Plant Resources, Institute of Botany, Jiangsu Province and Chinese Academy of Sciences , Nanjing 210014 , China; Nanjing Botanical Garden Mem. Sun Yat-Sen , Nanjing 210014 , China Department of Ophthalmology, Foshan Second People's Hospital, 78 Weiguo Road, Chancheng District, Foshan, Guangdong Province, China. School of Chemical and Biomedical Engineering Nanyang Technological University 62 Nanyang Drive Singapore 637459 Singapore Proteolix, Inc., 333 Allerton Avenue, South San Francisco, California 94080 Key Laboratory of Health Ministry in Congenital Malformation, the Affiliated Shengjing Hospital of China Medical University, Shenyang, PR China Department of Biochemistry and Molecular Biology (Y.L., L.J.S., I.A., K.M.I., C.B., D.D.P., C.G.W., R.L.L.), and Department of Plant Biology (D.W.Y., J.B.O., K.W.O., A.P.W., C.G.W., R.L.L.), Michigan State University, East Lansing Michigan 48824 College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China From the Departments of Anesthesiology (Q.W., S.C., B.H., J.D., Y.L., L.X.) and Orthopedics (Y.P.), Xijing Hospital, Fourth Military Medical University, Xi’an, China; and the Cell Engineering Research Center & Department of Cell Biology (X.G.), State Key Laboratory of Cancer Biology, Fourth Military Medical University, Xi’an, China. Department of Gastroenterology, Huzhou Central Hospital& Central Hospital, affiliated to Huzhou Teachers College, Huzhou, Zhejiang 313000, China Department of Biochemistry and Molecular Biology, State Key Laboratory of Medical Molecular Biology, School of Basic Medicine, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, Peking Union Medical College , Beijing, China State key Laboratory of Tree Genetics and Breeding, Key Laboratory of Silviculture of the National Forestry and Grassland Administration, Research Institute of Forestry, Chinese Academy of Forestry, Beijing 100091, P. R. China School of Chemical and Biomedical Engineering, Nanyang Technological University, 62 Nanyang Drive, Singapore 637459, Singapore. 1 Department of Gynecologic Oncology, The Affiliated Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, 2 Institute of Bioinformatics, Zhejiang University, Hangzhou, Zhejiang 310058, China, 3 Division of Respiratory Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China, 4 Department of Physiology and the Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA and 5 Human Molecular and Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA; 1 Department of Gynecologic Oncology, The Affiliated Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310006, 2 Institute of Bioinformatics, Zhejiang University, Hangzhou, Zhejiang 310058, China, 3 Division of Respiratory Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310058, China, 4 Department of Physiology and the Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA and 5 Human Molecular and Genetics Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA Aab Cardiovascular Research InstituteUniversity of Rochester Rochester New York USA Department of Gastrointestinal Surgery, Shunde Hospital, Southern Medical University, Shunde, Foshan, Guangdong 528308, P.R. China 2Surgical Science, Department of Surgery Department of Chemistry, The University of Texas at Austin, Austin, Texas 78712, United States Department of Pharmaceutical Sciences, University of Tennessee, Health Science Center, Memphis, Tennessee 38163, Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, Ohio 43210, St. Jude Children’s Research Hospital, Memphis, Tennessee 38103 1Washington University, St. Louis, Missouri; School of Resource and Environment, Northeast Agricultural University, Harbin 150030, China Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University Department of Gynecologic Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi 530021, P.R. China Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115 Department of Nephrology Yueyang Hospital of Integrated Traditional Chinese and Western Medicine, Shanghai University of Traditional Chinese Medicine Shanghai China Department of Dermatology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, Jiangsu Province, China Department of Psychiatry The Fourth People's Hospital of Zhangjiagang Suzhou PR China College of Chemistry, Chemical Engineering and Materials Science, Soochow University, 215123 Suzhou, China From the Division of Surgical Science (D.-x.B., V.R., X.S., R.R., Y.L., S.F.Y., E.N., A.M.S.), Department of Surgery; Department of Pathology (V.D.); and Biomedical Informatics Shared Resource (R.A.F.), Herbert Irving Comprehensive Cancer Center, Department of Biomedical Informatics, College of Physicians & Surgeons, Columbia University, New York. Emergency Department, Xiyuan Hospital, China Academy of Chinese Medical Science, Beijing, China Department of Endocrine and Metabolic Diseases, Shanghai Institute of Endocrinology and Metabolism, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China Department of Chronic Disease Prevention and Control Suzhou City Center for Disease Control and Prevention Suzhou China Department of Rheumatology, Affiliated Hospital of Nanjing University of Chinese Medicine, Jiangsu Province Hospital of Chinese Medicine, Nanjing 210017, China Key Laboratory of Metallurgical Equipment and Control Technology, Key Laboratory of Mechanical Transmission and Manufacturing Engineering, Wuhan University of Science and Technology, Wuhan 430081, China Department of Otorhinolaryngology, The Affiliated Hospital of Qingdao University, Qingdao, Shandong 266003, P.R. China State Key Laboratory of Hydrology, Water Resources and Hydraulic Engineering Nanjing Hydraulic Research Institute Nanjing China Comparative Orthopaedic Research Laboratory, School of Veterinary Medicine, University of Wisconsin-Madison, Madison, Wisconsin. School of Urban and Environmental Science, Huaiyin Normal University, Huai’an 223300, China; Jiangsu Key Laboratory for Eco-Agricultural Biotechnology around Hongze Lake, Huai’an 223300, China Department of Chemistry; Taiyuan Normal University; Jinzhong; China Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Department of Gynecologic Oncology Women's Hospital and Institute of Translational Medicine Zhejiang University School of Medicine Hangzhou Zhejiang China; Cancer center Zhejiang University Hangzhou Zhejiang China The Fourth Affiliated Hospital, College of Medicine, Zhejiang University, Yiwu 322000, China. Soft Matter and Functional Materials, Helmholtz-Zentrum Berlin für Materialien und Energie GmbH, Hahn-Meitner-Platz 1, 14109 Berlin, Germany; Institut für Phzsik, Humboldt-Universität zu Berlin, 12489 Berlin, Germany Institute of Sericulture and Apiculture, College of Animal Sciences Zhejiang University Hangzhou P. R. China National Engineering Research Center for Biomaterials, Sichuan University, Wangjiang Road 29, Chengdu 610064, China Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS‐MPG Partner Institute for Computational Biology (PICB) Shanghai Institutes for Biological Sciences, CAS Shanghai China Department of Urology Juntendo University Graduate School of Medicine Tokyo Japan Department of Anesthesiology and Pain Management, Xijing Hospital, Fourth Military Medical University, Xi’an 710032, China State Key Laboratory of Crop Gene Resources and Breeding, Institute of Crop Sciences Chinese Academy of Agricultural Sciences Beijing 100081 China Department of Rheumatology and Immunology Jiangsu Province Hospital of Chinese Medicine Nanjing China Department of Gynecologic Oncology, Women’s Hospital, Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang, China Department of Pharmacognosy, School of Pharmacy Fudan University Shanghai 201203 P. R. China School of Pharmacy, Department of Pharmacognosy, Fudan University , Shanghai, P.R. China State key Laboratory of Tree Genetics and Breeding, Key Laboratory of Silviculture of the National Forestry and Grassland Administration, Research Institute of Forestry, Chinese Academy of Forestry, Beijing, P. R. China State Key Laboratory of Superlattices and Microstructures, Institute of Semiconductors, Chinese Academy of Sciences, Beijing 100083, China From the College of Physicians and Surgeons, Columbia University, New York, New York, and Institut für Pharmazie und Lebensmittelchemie (M.P.), Abteilung Lebensmittelchemie, Universität Erlangen-Nürnberg, Erlangen, Germany. Beijing Key Laboratory of Water Resources and Environmental Engineering, School of Water Resources and Environment, China University of Geosciences, Beijing 100083, China. [email protected] Department of Medicine/Cardiology, Cardiovascular Research Laboratories (CVRL), University of California (UCLA), Los Angeles, California. Department of Physiology & the Cancer Center, Medical College of Wisconsin, Milwaukee, WI 53226, USA; Women’s Hospital & The Institute for Translational Medicine, School of Medicine, Zhejiang University, Hangzhou, Zhejiang 310029, China Key Laboratory of National Forestry and Grassland Administration for the Protection and Restoration of Forest Ecosystem in Poyang Lake Basin, Jiangxi Agricultural University, Nanchang, Jiangxi 330045, China Department of Chemistry, Ohio State University, Columbus, Ohio 43210 NCDs Prevention and Control Department, Suzhou CDC, Suzhou, China Department of Cardiology The First Affiliated Hospital of Nanjing Medical University Nanjing China; Cardiovascular Device and Technique Engineering Laboratory of Jiangsu Province Nanjing China Department of Orthopaedics, Binzhou Central Hospital Affiliated to Binzhou Medical University, Binzhou, Shandong 251700, P.R. China Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women's Hospital Harvard Medical School, 75 Francis Street, Boston, MA 02115, USA Soft Matter and Functional Materials Helmholtz-Zentrum Berlin für Materialien und Energie Hahn-Meitner-Platz 1 14109 Berlin Germany; Institute of Chemistry University of Potsdam 14476 Potsdam Germany Laboratory of Molecular Oncology, Institut de recherches cliniques de Montréal, Montréal, Québec H2W 1R7, Canada 1 Department of Anesthesiology, Affiliated Hospital of Chengde Medical College, Chengde Hebei 067000. [email protected]. Department of Radiation Oncology, Kecheng People's Hospital, Zhejiang Quzhou, People's Republic of China Department of Physics and ‡Nanoscale Science and Technology Laboratory, Institute for Advanced Study, Nanchang University, Nanchang 330031, P.R. China Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women’s Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou 310006, China; Cancer Center, Zhejiang University, Hangzhou 310013, China Chinese Academy of Sciences (CAS) Key Laboratory of Computational Biology, Max Planck Independent Research Group on Population Genomics, CAS‐MPG Partner Institute for Computational Biology (PICB), Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences University of Chinese Academy of Sciences, CAS Shanghai China Department of Surgery and the Alvin J. Siteman Cancer Center, Washington University School of Medicine, St. Louis, Missouri Laboratory of Earth Surface Processes, College of Urban and Environmental Sciences, Peking University, Beijing, 100871, China Ministry of Education Key Laboratory of Metabolism and Molecular Medicine, Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, Shanghai, China From the Division of Surgical Science, Department of Surgery, College of Physicians and Surgeons, Columbia University, New York, NY. Osteoporosis Research Center, Creighton University, Omaha, Nebraska 68131 Neuroscience Center of Excellence, School of Medicine, Louisiana State University Health New Orleans, 2020 Gravier St., New Orleans, LA 70112, USA College of Veterinary Medicine, Jilin University , Changchun, Jilin, China *Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative, and Pain Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115; and Center for Uterine Cancer Diagnosis and Therapy Research of Zhejiang Province, Women’s Reproductive Health Key Laboratory of Zhejiang Province, Women’s Hospital and Institute of Translational Medicine, Zhejiang University School of Medicine, Hangzhou, Zhejiang 310006, China Department of Ophthalmology, Changzheng Hospital, the Second Affiliated Hospital of the Second Military Medical University, Shanghai 200003, China ; Department of Ophthalmology, Jinling Hospital, School of Medicine, Nanjing University, Nanjing 210002, Jiangsu Province, China. Department of Dermatology The First Affiliated Hospital, Nanjing Medical University Nanjing Jiangsu Province People's Republic of China 1Department of Surgery and Department of Surgery, Herbert Irving Comprehensive Cancer Center, Columbia University, New York, New York; Department of Molecular Pharmacology and Physiology, University of South Florida College of Medicine, Tampa, Florida;; Department of Physiology/Pharmacology, University of Mississippi Medical Center, Jackson Mississippi Department of Neurosurgery Affiliated Hospital of Jining Medical University, & Shandong Provincial Key Laboratory of Stem Cells and Neuro‐oncology Jining China; Medical Research Center Affiliated Hospital of Jining Medical University Jining China The Tianjin Key Laboratory of Biomaterials Institute of Biomedical Engineering Peking Union Medical College and Chinese Academy of Medical Sciences 236# Baidi Road, Nankai District Tianjin 300192 China Department of Biochemistry and Molecular Biology (Y.L., L.J.S., C.G.W., R.L.L.), Bioinformatics Core, Research Technology Support Facility (M.D.L., C.G.W.), and Department of Plant Biology (C.G.W., R.L.L.), Michigan State University, East Lansing, Michigan 48824 Ernst Ruska-Centre for Microscopy and Spectroscopy with Electrons (ER-C 1) and Peter Grünberg Institute (PGI 5), Forschungszentrum Jülich GmbH, 52425 Jülich, Germany; Beijing Key Lab and Institute of Microstructure and Properties of Advanced Materials, Beijing University of Technology, Beijing 100124, China Neuroscience Center of Excellence, Louisiana State University Health Sciences Center, New Orleans, Louisiana; iHuman Institute; ShanghaiTech University; Shanghai; China; School of Life Science and Technology CAS Key Laboratory of Materials for Energy Conversion; Shanghai Institute of Ceramics; Chinese Academy of Sciences; Shanghai 200050; China Department of Cardiology First Affiliated Hospital of Dalian Medical University Dalian Liaoning China Department of Gynecologic Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, 530021, People’s Republic of China Neuroscience Center of Excellence, Louisiana State University Department of Physics; Nanchang University; Nanchang 330031; China Department of Anatomy, Medical College of Nantong University, Nantong 226001, China College of Horticulture and Landscape Architecture, Southwest University, Chongqing 400716, China; Key Laboratory of Horticulture Science for Southern Mountainous Regions, Ministry of Education, Chongqing 400715, China; School of Pharmacy, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Shanghai 201203, China Hospital of Beijing University of Aeronautics and Astronautics Key Laboratory of Atomic and Molecular Physics & Functional Materials of Gansu Province College of Physics and Electronic Engineering Northwest Normal University Lanzhou China Institute of Electrochemical Energy Storage Helmholtz-Zentrum Berlin für Materialien und Energie 14109 Berlin Germany; Institute of Chemistry University of Potsdam 14476 Potsdam Germany Department of Pharmacognosy, School of Pharmacy, Fudan University, Shanghai 201203, China. [email protected] Hainan Provincial Key Laboratory of Carcinogenesis and Intervention; Hainan Medical College; Haikou 571199 Hainan Province People's Republic of China; Key Laboratory of Molecular Biology; Hainan Medical College; Haikou 571199 People's Republic of China Anhui Province Key Laboratory of Medical Physics & Technology, Center of Medical Physics & Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, Anhui, PR China; Department of Pharmacy, Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei, Anhui, PR China Shanghai Public Health Clinical Center, Fudan University, Shanghai, People’s Republic of China Department of Endocrine and Metabolic Diseases (Y.D., H.W., Y.L., S.L., Q.Z., J.H., R.Z., J.Y., R.Z., D.Z., G.N., Y.Y.), Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Ruijin Hospital, Shanghai Jiaotong University School of Medicine, 197 Ruijin Rd II, Shanghai 200025, China College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, Winnipeg, Manitoba, Canada;; Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Hospital Research Centre, Winnipeg, Manitoba, Canada; Department of Endocrine and Metabolic Diseases; Shanghai Institute of Endocrinology and Metabolism; Shanghai Clinical Center for Endocrine and Metabolic Diseases; Ruijin Hospital; Shanghai Jiao Tong University School of Medicine; Shanghai, People's Republic of China Department of Epidemiology and Biostatistics, Nanjing Medical University School of Public Health, Nanjing 210029, Jiangsu Province, China. Freie Universität Berlin Institut für Chemie und Biochemie–Anorganische Chemie Fabeckstrasse 34/36 14195 Berlin Germany Department of Bacteriology CAS Key Laboratory of Materials for Energy Conversion, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China Department of Chronic Disease Prevention and Control Suzhou Center for Disease Control and Prevention Suzhou China Analytical Core, Center for Experimental Therapeutics and Reperfusion Injury, Department of Anesthesiology, Perioperative and Pain Medicine, Brigham and Women’s Hospital, Boston, Massachusetts, USA; Department of Oral Medicine, Infection and Immunity, Harvard School of Dental Medicine, Harvard Medical School, Boston, Massachusetts, USA Beijing Zoo, Beijing 100044, China Institute of Microstructure and Properties of Advanced Materials, Beijing University of Technology, Beijing 100124, China College of Pharmacy, Rady Faculty of Health Sciences, University of Manitoba, 750 McDermot Avenue, Winnipeg, MB R3E 0T5, Canada.; Canadian Centre for Agri-Food Research in Health and Medicine, St. Boniface Hospital Research Centre, 351 Taché Avenue, Winnipeg, MB R2H 2A6, Canada. Department of Otolaryngology Head and Neck Surgery the First Affiliated Hospital of Liaoning Medical University Jinzhou China University of Tennessee Health Science Center, Memphis, Tennessee 38103 Department of Endocrinology and Metabolism Zhongshan Hospital Fudan University Shanghai China State Key Laboratory of Clean Energy Utilization, College of Energy Engineering, Zhejiang University, Hangzhou 310027, China. Authors' Affiliations: 1Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, Saint Louis, Missouri; Departments of 2Physiology and 3Pharmacology and Toxicology, Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin; 4Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama; and 5Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland; Authors' Affiliations: 1Department of Surgery and The Alvin J. Siteman Cancer Center, Washington University School of Medicine, Saint Louis, Missouri; Departments of 2Physiology and 3Pharmacology and Toxicology, Cancer Center, Medical College of Wisconsin, Milwaukee, Wisconsin; 4Department of Surgery, University of Alabama at Birmingham, Birmingham, Alabama; and 5Division of Cancer Prevention, National Cancer Institute, Bethesda, Maryland Nanjing Chinese Medicine Hospital, Nanjing, Jiangsu, China (mainland) Department of Gastroenterology, The First Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, China State Key Laboratory of Pharmaceutical Biotechnology, and Model Animal Research Center (MARC) of Nanjing University, Nanjing University, Nanjing, China. School of Chemistry and Environmental Science, Henan Normal University, Xinxiang 453007, People’s Republic of China Department of Ophthalmology, Beijing Shijitan Hospital, Capital Medical University, Beijing, China. The State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institute of Ceramics Chinese Academy of Sciences Shanghai 200050 P. R. China; Center of Materials Science and Optoelectronics Engineering University of Chinese Academy of Sciences Beijing 100049 China From the Department of Pathology and Laboratory Medicine (Z.L., S.P.X., H.X.), University of Rochester Medical Center and Aab Cardiovascular Research Institute (Z.L., J.A., Y.L., T.S., C.M., C.Y., S.P.X., T.M.S., H.X.), University of Rochester School Medicine and Dentistry, Rochester, NY; and the Department of Cellular and Molecular Pharmacology (J.T.), University of California, San Francisco, Calif. Authors' Affiliations: 1Division of Pharmaceutics, College of Pharmacy, The Ohio State University, Columbus, Ohio; and 2Preclinical Research and Development, GTx Inc., and 3Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee Department of Prenatal Diagnostic Centre, Huizhou Central People's Hospital, Huizhou, Guangdong, China. Department of Biological Sciences, Western Michigan University, Kalamazoo, MI, USA. [email protected] Department of Pharmaceutical Sciences, University of Tennessee Health Science Center, Memphis, Tennessee 38163, United States Renal Division, Washington University School of Medicine, St. Louis, Missouri, USA Institute of Advanced Synthesis (IAS); School of Chemistry and Molecular Engineering; Jiangsu National Synergetic Innovation Centre for Advanced Materials; Nanjing Tech University; Nanjing 211816 Department of Physics; School of Sciences; Nanchang University; Nanchang; PR China Medical Physics and Technology Center, Hefei Academy of Physical Sciences, Chinese Academy of Sciences，Hefei 230031, Anhui Province, China. Department of Gynecologic Oncology, Guangxi Medical University Cancer Hospital, Nanning, Guangxi, PR China. Department of Otolaryngology Head & Neck Surgery; The First Hospital; Jinzhou Medical University; Jinzhou 121001; China China‐American Cancer Research Institute Dongguan Scientific Research Center Guangdong Medical University Dongguan China; Key Laboratory for Epigenetics of Dongguan City Dongguan China; Key Laboratory for Medical Molecular Diagnostics of Guangdong Province Dongguan China Institute of Soft Matter and Functional Materials, Helmholtz-Zentrum Berlin 2 , Hahn-Meitner-Platz 1, 14109 Berlin, Germany Anhui Province Key Laboratory of Medical Physics and Technology, Institute of Health and Medical Technology, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei 230031, Anhui, China; Hefei Cancer Hospital, Chinese Academy of Sciences, Hefei 230031, Anhui, China Food Science and Human Nutrition Department, Institute for Food and Agricultural Sciences, University of Florida, Gainesville, Florida Department of Cardiology, First Affiliated Hospital of Dalian Medical University, Dalian, Liaoning Department of Pharmaceutical Sciences, College of Pharmacy, University of Tennessee Health Science Center, Memphis, Tennessee 38163, and University of Cincinnati Drug Discovery Center, University of Cincinnati, Cincinnati, Ohio 45237 |
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