http://rdf.ncbi.nlm.nih.gov/pubchem/author/MD5_e1871d82540f8ca48fdf5896f91d7983
Outgoing Links
| Predicate | Object |
|---|---|
| family-name | Yang. Ping Yang Yang |
| name | Ping Yang Ping Yang. |
| given-name | Ping |
| organization-name | Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota School of Architecture and Environment, Sichuan University, Chengdu 610065, China Institute of Biomedical Engineering, Qilu University of Technology, Jinan 250000, Shandong, China. Division of Health Sciences Cancer Center and College of Medicine, Mayo Clinic Rochester MN USA Department of Materials Science and Engineering National University of Singapore 9 Engineering Drive 1 Singapore 117575 Singapore; Singapore Synchrotron Light Source (SSLS) National University of Singapore 5 Research Link Singapore 117603 Singapore Department of Pathology, Yantai Yuhuangding Hospital, Affiliated Hospital of Qingdao University, Yantai, China Centre for Lipid Research & Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, 400016 Chongqing, China Libao Central Health Cente, Hai'an City, Jiangsu Province Hai'an 226600, Jiangsu Province, China. Department of Pharmacognosy, College of Pharmaceutical Science, Soochow University, Suzhou, China Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA Instrumental Analysis Centre School of Pharmacy, Fudan University Shanghai 201203 China Department of Orthopaedic Surgery, Washington University School of Medicine, 660 S Euclid Ave., St Louis, MO 63110, USA Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China College of Water Conservancy and Hydropower Engineering, Sichuan Agricultural University, Ya’an, 625014, People's Republic of China The Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology 1095 Jiefang Ave., Wuhan 430030, China. State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Graduate University of the Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, P. R. China Department of Hepatic Surgery Eastern Hepatobiliary Surgery Hospital Naval Military Medical University Shanghai China; Department of Stomatology Eastern Hepatobiliary Surgery Hospital Naval Military Medical University Shanghai China Mayo Clinic, Scottsdale, AZ, US. NingBo College of Health Sciences Yinzhou China Departments of Ophthalmology and Visual Sciences and Singapore Synchrotron Light Source, National University of Singapore, 5 Research Link, 117603, Singapore Department of Infection Management, Tianmen First People’s Hospital, Tianmen, China Theoretical Division, Los Alamos National Laboratory, MS B268, Los Alamos, New Mexico 87545 Department of Clinical Laboratory, Tianjin Huanhu Hospital, Tianjin Key Laboratory of Cerebral Vessels and Neural Degeneration, Tianjin, China Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, United States T-CNLS: Center for Nonlinear Studies Los Alamos National Laboratory 87545 Los Alamos New Mexico USA School of Material Science and Engineering University of Jinan 250022 Jinan China 6Mayo Clinic College of Medicine, Rochester, Minnesota; From the Division of Epidemiology and Cancer Center, Nicotine Dependence Center, Division of Primary Care Internal Medicine, and Department of Molecular Pharmacology and Experimental Therapeutics, Rochester, MN Department of Zoology, University of Toronto, Mississauga, Ontario L5L 1C6, Canada; Department of Biology, York University, Toronto, Ontario M3J 1P3, Canada Singapore Synchrotron Light Source (SSLS), National University of Singapore, 117603 Singapore Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai, China Edward Mallinckrodt Department of Pediatrics, and Los Alamos National Laboratory, Los Alamos, New Mexico 87545, and W.R. Wiley Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99352 School of Chemistry and Materials Science, Shaanxi Normal University, Xi'an 710062, People's Republic of China , , Department of Obstetrics and Gynecology, Beijing YouAn Hospital Key Laboratory of Thermo-Fluid Science and Engineering, Ministry of Education, Xi’an Jiaotong University, Xi’an 710049, Shaanxi, P. R. China Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, China. CAS Key Laboratory of Systems Microbial Biotechnology, Tianjin Key Laboratory for Industrial Biological Systems and Bioprocessing Engineering, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin, 300308, China. Fax: +86-22-84861942 Vasculocardiology, the Affiliated Hospital of Southwest Medical University, Luzhou City Smart City College, Beijing Union University, Beijing, China School of Materials Science and Engineering, University of Jinan, 250022, Jinan, P. R. China National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang 550025, China State Key Laboratory of Oncology in Southern China, Guangzhou, China; Department of Urology, Sun Yat-Sen University Cancer Center, Guangzhou, China; Collaborative Innovation Center for Cancer Medicine, Guangzhou, China School of Biomedicine Sciences Chengdu Medical College Chengdu 610500 China State Key Laboratory of Subtropical Silviculture, Bamboo Industry Institute, Zhejiang A&F University, Lin’an, Hangzhou 311300, Zhejiang, China Centre for Lipid Research & Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, P.R. China; Department of Obstetrics and Gynecology, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, P.R. China; Department of Orthopaedic Surgery, Johns Hopkins University School of Medicine, Baltimore, MD, USA Division of Epidemiology, Department of Quantitative Health Sciences, Mayo Clinic, Scottsdale, AZ 85260, USA School of Materials Science and Engineering, Nanjing Institute of Technology, Nanjing, 211167, China Shandong Provincial Key Laboratory of Preparation and Measurement of Building Materials, Key Laboratory of Inorganic Functional Materials of Shandong Universities, School of Material Science and Engineering University of Jinan 250022 Jinan People's Republic of China Fangsong Community Health Centre Shanghai China Department of General Surgery, Guangzhou Digestive Disease Centre, Guangzhou First People's Hospital, The Second Affiliated Hospital of South China University of Technology, Guangzhou, Guangdong 510000, P.R. China College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University, Nanyang, Henan 473061, P. R. China National Center for STD & Leprosy Control, Institute of Dermatology, Chinese Academy of Medical Sciences & Peking Union Medical College, Nanjing, Jiangsu, China Mayo Clinic Cancer Center, Rochester, MN 55905, USA Braun Laboratories, California Institute of Technology, Pasadena, California 91125 Faculty of Basic Medical Science, Kunming Medical University, Kunming 650500, P. R. China From the Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China (X.R., S.Z., Q.L., P.Y., D.W., C.Y.W.), and Center for Biotechnology and Genomic Medicine (X.R., J.Z., Y.Z., P.Y., C.Y.W.), Department of Physiology (M.H.W.), Vascular Biology Center (D.J.F.), Cancer Center (H.S.), and Department of Anatomy and Cell Biology (Z.D.), Georgia Health Sciences University, Augusta. for the CTS-AMI Investigators School of Life Sciences, Sun Yat-sen University, Guangzhou, China Department of Analytical Chemistry China Pharmaceutical University Nanjing 211198 P. R. China School of Pharmacy, Fudan University, Shanghai 201203,China State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China School of Pharmacy, National Defense Medical Center, Taipei, Taiwan Singapore Synchrotron Light Source (SSLS), National University of Singapore, 3 Science Drive 3, Singapore 117543 Department of Hematology,Peking University Third Hospital,Beijing 100191,China. Department of Burns and Plastic Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School , NO. 321, Zhongshan Road, Nanjing, Jiangsu , China Key Laboratory of Preclinical Study for New Drugs of Gansu Province, School of Basic Medical Sciences, Institute of Pharmaceutics, School of Pharmacy, and Research Unit of Peptide Science, Chinese Academy of Medical Sciences, 2019RU066, Lanzhou University, Lanzhou 730000, P. R. China School of Geographical Sciences, Fujian Normal University, Fuzhou 350007, China. Key Laboratory of Humid Sub-tropical Eco-geographical Process of Ministry of Education, Fuzhou 350007, China. College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P. R. China Department of Psychiatry, Brains Hospital of Hunan Province, Clinical Medical School, Hunan University of Chinese Medicine, Changsha, Hunan 410007, P.R. China Division of Mechanics and Acoustics, National Institute of Metrology, Beijing 100029, China Department of Obstetrics and Gynecology 1st Affiliated Hospital of Jinan University Guangzhou China Department of Vasculocardiology, the Affiliated Hospital of Southwest Medical University, Luzhou City, Sichuan Province, China College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, China Jilin Provincial Cardiovascular Research Institute, Department of Cardiology in the Third Hospital of Jilin University, Jilin, China The School of Public Health, Institute for Chemical Carcinogenesis Guangzhou Medical University Guangzhou Guangdong People's Republic China Department of Hematology Peking University Third Hospital Beijing China Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China Department of Environmental Science and Engineering, College of Architecture and Environment, Sichuan University, Chengdu, People’s Republic of China College of Chemistry and Pharmaceutical Engineering, Nanyang Normal University; Nanyang; P. R. China Department of Pathology, Affiliated Yantai Yuhuangding Hospital of Qingdao University, Yantai, Shandong 264000, P.R. China Department of Clinical Laboratory The Affiliated Drum Tower Hospital of Nanjing University Medical School Nanjing China Department of Pathophysiology, School of Medicine Nantong University Nantong Jiangsu China Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu, China; Division of Infectious Diseases, State Key Laboratory of Biotherapy, Chengdu, China Health Research Institute, National Institute of Advanced Industrial Science and Technology, Midorigaoka, Ikeda-city, Osaka 563-8577, Japan State Key Laboratory for Manufacturing Systems Engineering, International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technologies, Xi’an Jiaotong University (Yantai) Research Institute for Intelligent Sensing Technology and System, Xi’an Jiaotong University, Xi’an710049, China; School of Mechanical Engineering, Xi’an Jiaotong University, Xi’an710049, China; Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing, Yantai265503, China Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, China (P.Y., H.S., K.L., W.C., Y.H.). Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou 510180, China Cardiac Rhythm Disease Management Therapy Delivery Systems Research, Medtronic, Minneapolis, Minnesota; Department of Vasculocardiology, the Affiliated Hospital of Southwest Medical University, Luzhou, China Center for Drug Evaluation, National Medical Products Administration Beijing 100022, China. Department of Medical Oncology, The Sixth Medical Centre of PLA General Hospital, Beijing, China Department of Pathology & Laboratory Medicine Schulich School of Medicine and Dentistry Western University London Ontario Canada; Cytogenetics Laboratory London Health Sciences Centre London Ontario Canada State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry Chinese Academy of Sciences 345 Lingling Lu Shanghai 200032 China The School of Public Health, Institute for Chemical Carcinogenesis, Guangzhou Medical University, Guangzhou 510182, Guangdong, People's Republic China Key Laboratory for Advanced Technologies of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, P. R. China College of Chemistry, Chemical Engineering and Materials Science Soochow University Suzhou 215123 P. R. China Department of Analytical Chemistry, China Pharmaceutical University, Nanjing 211198, China Department of Gastroenterology, The Affiliated Hospital of Medical School Ningbo University Ningbo China Center for Individualized Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA. School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu610031, China MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu Province, China Department of Laboratory Medicine, the First Affiliated Hospital of Chongqing Medical University, Chongqing, P.R. China Department of Ultrasound Zhongshan Hospital Fudan University Shanghai Institute of Imaging Medicine Shanghai China The Third Hospital of Jilin University, Changchun, Jilin Province, China. BARDS, MSD China Holding Co, Ltd, Shanghai, China Department of Gastrointestinal Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou Guangdong 510180, P.R. China Department of Cardiology, the First Affiliated Hospital of Kunming Medical College, Kunming 650032, China. Key Laboratory for Advanced Technologies of Materials Ministry of Education Chengdu 610031 P. R. China; School of Material Science and Engineering Southwest Jiaotong University Chengdu 610031 P. R. China Department of Endocrinology Shandong Rongjun General Hospital Jinan Shandong China College of Food Science and Technology Guangdong Ocean University Zhanjiang PR China Department of Oncology, PLA Navy General Hospital, Beijing 100048, China. Instrumental Analysis Center, School of Pharmacy, Fudan University, Shanghai, PR China Institute of Biomaterials and Surface Engineering, Key Lab. for Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, No. 111 of the North 1st Section of Second Ring Road, Chengdu 610031, China Center for Biotechnology and Genomic Medicine, Department of Pathology, Medical College of Georgia, Augusta, Georgia Key Lab. for Advanced Technologies of Materials, Ministry of Education, School of Material Sciences and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, PR China Institute for Viral HepatitisDepartment of Infectious DiseasesCentre for Lipid ResearchKey Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education)The Second Affiliated HospitalChongqing Medical University Chongqing China Department of Cardiology, China-Japan Union Hospital, Jilin University, Changchun, Jilin, China (mainland) Department of Biochemistry, University of Texas Health Center, Tyler, Texas; and the The Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Department of Respiratory and Critical Care Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, 1095 Jiefang Ave., Wuhan 430030, China. Key Laboratory of Humid Sub-tropical Eco-geographical Process of Ministry of Education, Fuzhou 350007, China. Chenyang Dai, Yijiu Ren, Hui Zheng, Dong Xie, Ke Fei, Gening Jiang, Chang Chen, Shanghai Pulmonary Hospital, Tongji University School of Medicine; and Yaxing Shen, Zhongshan Hospital, Fudan University, Shanghai, People’s Republic of China; Jianfei Shen, Shengyi Zhong, Jiaxi He, Wenhua Liang, Jianxing He, First Affiliated Hospital of Guangzhou Medical University and Guangzhou Research Institute of Respiratory Disease, Guangzhou, People’s Republic of China; Ping Yang, Mayo Clinic College of Medicine,... Institute of Electronic, Changzhou College of Information Technology, Changzhou 213164, China Edward Mallinckrodt Department of Pediatrics Centre for Lipid Research, Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. Authors' Affiliations: 1Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics, 2Division of Epidemiology, Department of Health Sciences Research, and 3Division of Biostatistics and Bioinformatics, Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota Department of Burn Surgery, Third Xiangya Hospital, Central South University, Changsha, Hunan 410013, P.R. China The Second Clinical School of Guangzhou Medical University, Guangzhou 510260, China. 1Cancer Prevention Fellowship Program, Office of Preventive Oncology, Division of Cancer Prevention, 2Laboratory of Human Carcinogenesis, National Cancer Institute, Center for Cancer Research, and 3Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; 4Division of Epidemiology and 5Advanced Genome Technology Center, Mayo Clinic, Rochester, Minnesota; 6Lombardi Comprehensive Cancer Center, Georgetown University, Washington, District of Columbia; 7Cancer Prevention and Control Program, Hollings Cancer Center, Medical University of South Carolina, Charleston, South Carolina Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota Department of Health Sciences Research, Division of Epidemiology, Mayo Clinic, Minnesota, United States of America Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, USA; Mayo Clinic Cancer Center, Rochester, MN, USA Key Lab. for Advanced Technologies of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031,China Department of Radiotherapy, The First Affiliated Hospital of Hainan Medical University, Haikou, China Department of Neurology, Affiliated People's Hospital of Nanchang University, Jiangxi 330006, P.R. China College of Architecture and Environment, Sichuan University, Chengdu, 610065, China Singapore Synchrotron Light Source (SSLS), National University of Singapore 117603, Singapore Department of Cardiology, First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, 650032, China School of Pharmacy, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, 18 Tianshui Middle Road, Lanzhou 730000,China, and Graduate University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China Department of Mechanics and Aerospace Engineering, Southern University of Science and Technology (SUSTech), Shenzhen 518055, China; Institute of Advanced Materials (IAM), Key Laboratory for Organic Electronics & Information Displays (KLOEID), Nanjing University of Posts & Telecommunications (NUPT), 9 Wenyuan Road, Nanjing 210023, China Division of Diabetes, Endocrinology, and Metabolism, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania Analytical and Testing Center, School of Pharmacy, Fudan University, 826 Zhangheng Road, Pudong District, Shanghai 201203, China All authors: Mayo Clinic, Rochester, MN. Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87544, United States Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA. Theoretical Division Los Alamos National Laboratory Los Alamos New Mexico 87545 USA School of Chemistry and Environment College of Food Science and Technology Guangdong Ocean University Zhanjiang China Department of Cardiology, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130031, P.R. China Cyrus Tang Hematology Center, Jiangsu Institute of Hematology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, China.; Key Laboratory of Thrombosis and Hemostasis, Ministry of Health, Suzhou, Jiangsu, China. Sichuan Science City Hospital Mianyang China Pacific Northwest National Laboratory, P.O. Box 999, Richland, Washington 99352, United States Institute of Plant and Microbial Biology University of Zurich Zurich Switzerland From the Department of Health Sciences Research and Division of General Thoracic Surgery, College of Medicine, Mayo Clinic, Rochester, MN MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Jiangsu, China; College of Animal Science & Technology, Nanjing Agricultural University, Jiangsu, China Institute of Biomaterials and Surface Engineering, Key Lab. for Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, No. 111 of the North First Section of Second Ring Road, Chengdu 610031, PR China Department of Health Sciences Research, Mayo Clinic, Scottsdale, AZ School of Pharmacy, Shanghai Jiao Tong University, Shanghai, China. Department of Radiotherapy, The First Affiliated Hospital of Hainan Medical University, Haikou; Department of Radiotherapy, The First Affiliated Hospital of Guangxi Medical University, Nanning Singapore Synchrotron Light Source National University of Singapore 5 Research Link Singapore 117603 Singapore Los Alamos National Laboratory 1 Theoretical Division, , Los Alamos, New Mexico 87545, USA Institute of Biomedical Engineering, College of Medicine, Southwest Jiaotong University, Chengdu 610031, Sichuan, China; Key Laboratory of Advanced Technologies of Materials Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, Sichuan, China Research Centre of Wetlands in Subtropical Region, Fujian Normal University, Fuzhou 350007, China. Key Laboratory of Humid Sub-tropical Eco-geographical Process of Ministry of Education, Fuzhou 350007, China. Key Laboratory of South China Agricultural Plant Molecular Analysis and Genetic Improvement, Guangdong Provincial Key Laboratory of Applied Botany, South China Botanical Garden, Chinese Academy of Sciences, Guangzhou 510650, China; University of Chinese Academy of Sciences, Chinese Academy of Sciences, Beijing 100049, China Authors' Affiliations: Departments of 1Epidemiology, 2Thoracic and Cardiovascular Surgery, 3Thoracic/Head and Neck Medical Oncology, and 4Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, and 5Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, Texas; Departments of 6Laboratory Medicine and Pathology, 7Health Sciences Research, and 8Surgery, and 9Division of Medical Oncology, Mayo Clinic College of Medicine, Rochester, Minnesota; 10Department of Pathology, Medical College of Wisconsin, Milwaukee, Wisconsin; 11Department of Medicine, School of Medicine, National Yang-Ming University, Taipei, Taiwan; 12Division of Chest Medicine, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan; 13Institute of Biomedical Sciences, National Chung-Hsing University, Taichung, Taiwan; 14School of Medicine, China Medical University, Taichung, Taiwan; 15Department of Internal Medicine, National Taiwan Universit Department of Hematology, Peking University Third Hospital, Beijing 100191, China. Department of Obstetrics and Gynecology, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, P.R. China. Department of Stomatology, AnTing Campus, The Third Affiliated Hospital of Naval Military Medical University, Shanghai 200438, P.R. China Department of Plastic and Reconstructive Surgery, Ninth People's Hospital, Affiliated to Shanghai Jiaotong University, Shanghai, 200011, P.R. China. Department of Ultrasonography, Wuhan Sixth Hospital, Affiliated Hospital of Jianghan University, Wuhan, China School of Basic Medicine Department of Cardiology, The Third Hospital of Jilin University, Jilin Provincial Engineering Laboratory for Endothelial Function and Genetic Diagnosis of Cardiovascular Disease, Changchun, Jilin, China Key Laboratory of Grain and Oil Processing and Food Safety of Sichuan Province; College of Food and Bioengineering; Xihua University; Chengdu; China Institute of Biomaterials and Surface Engineering Key Lab. for Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu, China School of Pharmacy and Bioengineering, Chengdu University, Chengdu, PR China; Health Research Institute, National Institute of Advanced Industrial Science and Technology, 1-8-31 Midorigaoka, Ikeda-city, Osaka 563-8577, Japan CUNY Environmental CrossRoads Initiative, The City College of New York, City University of New York, 160 Convent Avenue, New York City, New York 10031, United States Key Laboratory of Functional Small Organic Molecule, Jiangxi Normal University, Ministry of Education, Nanchang 330022, China Department of Ultrasound, The First People's Hospital of Neijiang Department of Infectious Diseases Affiliated Hospital of Zunyi Medical University Zunyi Guizhou Province China Department of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing 100191, P.R. China Genome Diversity, Department Genebank, Leibniz Institute of Plant Genetics and Crop Plant Research, D-06466 Gatersleben, Germany; Los Alamos National Laboratory, Los Alamos, New Mexico 87545 Xi’an Jiaotong University Department of Anal-Colorectal Surgery, General Hospital of Ningxia Medical University, Yinchuan, China From the Institute of Cardiovascular Diseases (L.L., Y.N.W., W.H.S., Z.H.L., L.J.P., K.Y., L.J.W., Z.B.Z., H.M., P.Y., Q.J.C., W.F.S.), Medical School of Jiaotong University, and Department of Cardiology (L.L., Q.Z., L.J.W., Z.B.Z., R.D., W.F.S.), Rui Jin Hospital, Medical School of Jiaotong University, Shanghai, People’s Republic of China; Key Laboratory of Pathophysiology, Department of Pathophysiology, Medical School of Jiaotong University, Shanghai, People’s Republic of China (L.S.W.); and... College of Pharmacy, Southwest Medical University, Luzhou 646000, China. Sichuan Academy of Chinese Medicine Sciences, Chengdu 610041, China. Key Lab. for Advanced Technologies of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu, PR China Department of Clinical Laboratory, Tianjin Huan Hu Hospital Tianjin Key Laboratory of Cerebral Vascular and Neurodegenerative Disease Tianjin China Division of Epidemiology, Mayo Clinic, Rochester, Minnesota Center for Reproductive Medicine, Cheeloo College of Medicine, Shandong University, Key Laboratory of Reproductive Endocrinology of Ministry of Education, Shandong University, Shandong Key Laboratory of Reproductive Medicine, Jinan, China Key Laboratory of Advanced Technology for Materials of the Education Ministry, School of Materials Science and Engineering, Southwest Jiaotong University, 610031 Chengdu, China Key Laboratory of Animal Physiology and Biochemistry; Ministry of Agriculture; College of Veterinary Medicine; Nanjing Agricultural University; Nanjing PR China School of Mechatronic Engineering, China University Mining and Technology (Beijing Campus), Beijing 100083, China. Laboratory of Animal Cell Biology and Embryology College of Veterinary Medicine Nanjing Agricultural University Nanjing China Instrumental Analysis Center, School of Pharmacy, Fudan University, Shanghai, 201203, P. R. China Division of Epidemiology, Department of Quantitative Health Sciences , Mayo Clinic, Scottsdale, AZ 85259, USA Chemistry Division and ‡Theoretical Division, Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States Cardiology Department Department of Food Engineering School of Food Engineering Jilin Agriculture and Technology University Jilin PR China College of Chemistry; Chemical Engineering and Materials Science; Soochow University; Suzhou 215123, P. R. China Key Laboratory of Industrial Ecology and Environmental Engineering (MOE), Department of Environmental Science and Technology, Dalian University of Technology, Dalian 116024, China, and National Marine Environmental Monitoring Center, Dalian 116023, China Microsystem and Terahertz Research Center, China Academy of Engineering Physics, Chengdu 610200, China; Institute of Electronic Engineering, China Academy of Engineering Physics, Mianyang 621999, China Edward Mallinckrodt Department of Pediatrics Washington University in St. Louis School of Medicine and St. Louis Children's Hospital St. Louis Missouri USA Department of Neurobiology Chongqing Key Laboratory of Neurobiology Third Military Medical University Chongqing People's Republic of China Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130031, China Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences, Beijing 100193, China The Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology 1095 Jiefang Ave, Wuhan 430030, China. School of Material Science and Engineering, University of Jinan, Jinan, 250022, PR China Departments of Medicine and Pharmacology, Vanderbilt University School of Medicine, Nashville, TN Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, Jiangsu Province, China From the Experimental and Molecular Cardiology Group, Department of Experimental Cardiology (C.R.B., T.T.K., A.A.M.W.), Department of Clinical Genetics (C.R.B.), and Department of Clinical Epidemiology and Biostatistics (M.W.T.T.), Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands; Division of Cardiology, Department of Internal Medicine (W.S., S.K.), and Laboratory of Molecular Genetics (Y.M.), National Cardiovascular Center, Suita, Osaka, Japan; and Department of Medicine... The Center for Biomedical Research, Department of Respiratory and Critical Care Medicine, Key Laboratory of Pulmonary Diseases of Health Ministry, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Wuhan, China Beijing Higher Institution Engineering Research Center of Testing and lmaging School of Material Science and Engineering, University of Jinan, Jinan 250022, China Mayo Clinic College of Medicine and Science, Mayo Clinic Arizona, 13400 E. Shea Boulevard, Scottsdale, AZ, USA Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin 130033, China Department of Obstetrics and Gynecology, Jiangwan Hospital, Shanghai 200434, P.R. China Cancer Research Institute, Key Laboratory of Tumor Cellular & Molecular Pathology, Medical College of Hengyang, University of South China, Hengyang, Hunan 421001, China Department of Ophthalmology, Duke University Medical Center, Durham, North Carolina, United States Department of General Surgery, Tangdu Hospital, The Air Force Military Medical University, Xi’an 710032, China Authors' Affiliations: Departments of 1Epidemiology and Biostatistics, School of Medicine; 2Internal Medicine and Genetics; 3Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, Ohio; Departments of 4Genetics, 5Biostatistics, The University of Texas MD Anderson Cancer Center; 6Department of Pediatrics, Division of Hematology-Oncology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas; 7Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center; 8The Neurological Institute of Columbia University, New York; 9Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut; 10Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts; 11Division of Epidemiology and Biostatistics, University of Illinois at Chicago, Chicago, Illinois; 12Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom; 13Cancer Control and Prevention Program, Department of Co Department of Cardiology, China-Japan Union Hospital of Jilin University; Jilin Provincial Key Laboratory for Genetic Diagnosis of Cardiovascular Disease; Jilin Provincial Engineering Laboratory for Endothelial Function and Genetic Diagnosis of Cardiovascular Disease; Jilin Provincial Molecular Biology Research Center for Precision Medicine of Major Cardiovascular Disease; Jilin Provincial Cardiovascular Research Institute Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4, Canada; Saskatchewan Health Services Utilization and Research Commission, University of Saskatchewan, Saskatoon, Saskatchewan S7N 0W8, Canada 12Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota. Instrumental Analysis Centre, School of Pharmacy, Fudan University, Shanghai 201203, P.R. China Authors' Affiliations: 1Department of Health Sciences Research; 2Division of Biomedical Statistics and Informatics; 3Genomics Shared Resource; 4Department of Laboratory Medicine and Pathology; 5Division of Medical Oncology; 6Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic College of Medicine, Rochester, Minnesota; and 7Department of Epidemiology, College of Preventive Medicine, Third Military Medical University, Chongqing, People's Republic of China Chinese Academy of Science Laboratory of Advanced Design, Manufacturing & Reliability for MEMS/NEMS/ODES, Jiangsu University, Zhenjiang 212013, P. R. China Department of Obstetrics, Yantai Yuhuangding Hospital , 20 Yudong Road, Zhifu District, Shandong Province, 264000 , Yantai , Shandong , China The First People’s Hospital of Lianyungang, Lianyungang, 222000 Jiangsu, China School of Material Science and Engineering University of Jinan 250022 Jinan People's Republic of China Department of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing, China Division of Nanomaterials and Chemistry, Hefei National Laboratory for Physical Sciences at Microscale, Department of Chemistry, the National Synchrotron Radiation Laboratory, University of Science and Technology of China, Hefei, Anhui 230026, P. R. China; Department of Chemistry and Chemical Engineering, Huainan Normal University, Huainan, Anhui 232001, P. R. China Authors' Affiliations: 1Department of Epidemiology, University of Texas M.D. Anderson Cancer Center, Houston, Texas; 2University of Cincinnati, Cincinnati, Ohio; 3Mayo Clinic College of Medicine, Rochester, Minnesota; 4Karmanos Cancer Institute, Wayne State University, Detroit, Michigan; 5University of Colorado, Denver, Colorado; 6University of Texas Southwestern Medical Center, Dallas, Texas; 7National Cancer Institute, NIH, Bethesda, Maryland; 8Louisiana State University Health Sciences Center, New Orleans, Louisiana; 9Washington University, St. Louis, Missouri; 10Saccomanno Research Institute, Grand Junction, Colorado; 11Medical College of Ohio, Toledo, Ohio; and 12National Human Genome Research Institute, Baltimore, Maryland College of Civil Engineering, Nanjing Forestry University, Nanjing 210037, China Ningbo College of Health Sciences Core Medical Imaging Facility Zhejiang University School of Medicine Zhejiang China Zhejiang University of Technology, HangZhou 310023, China Department of Medical Oncology, Sixth Medical Center of PLA General Hospital Beijing 100048, China. Department of Anesthesiology, Tongji Hospital, Tongji Medical College Huazhong University of Science and Technology Wuhan China Department of Neurosurgery, Beijing Children's Hospital Capital Medical University, National Center for Children's Health Beijing China Faculty of Life Science and Technology, Kunming University of Science and Technology, Kunming, Yunnan, P. R. China UC Davis Cancer Center/Basic Sciences, University of California at Davis, Sacramento, California, USA; Department of Pathology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, People's Republic of China Edward Mallinckrodt Department of PediatricsWashington University School of MedicineSt. Louis Missouri 5Mayo Clinic College of Medicine, Rochester, Minnesota; College of Food Science and Technology, Guangdong Ocean University, Zhanjiang, Guangdong Province, China Key Laboratory for NeuroInformation of Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu 610054, China Key Laboratory of Organ Transplantation NHC Key Laboratory of Organ Transplantation Key Laboratory of Organ Transplantation Ministry of Education The Center for Biomedical Research, Chinese Academy of Medical Sciences Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan China School of Pharmacy Fudan University Shanghai China Ping Yang, Department of Emergency, The First Affiliated Hospital of Xinxiang Medical University, Weihui, China. Merck & Co., Inc. Kenilworth New Jersey f Division of Epidemiology, Mayo Clinic, Rochester, Minnesota, USA Singapore Synchrotron Light Source (SSLS) National University of Singapore Singapore 117603 Singapore Singapore Synchrotron Light Source, National University of Singapore, 117603 Singapore China Pharmaceutical University, Key Laboratory of Drug Metabolism and Pharmacokinetics, 1 Shennong Road, Nanjing, Jiangsu 210038, People’s Republic of China; Vanderbilt University School of Medicine, Division of Clinical Pharmacology, Departments of Medicine and Pharmacology, Nashville, TN 37232-6602, USA. Medical College Qingdao University Qingdao China Department of Burn, Plastic and Cosmetic Surgery, Chaohu Hospital of Anhui Medical University, Hefei, China From the Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, Georgia BGI-Shenzhen, Shenzhen 518083, China; China National GeneBank, BGI-Shenzhen, Shenzhen 518120, China Department of Pathology, Sun Yat-sen University Cancer Center , Guangzhou , PR China; State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-sen University Cancer Center , Guangzhou , PR China Division of Epidemiology , Department of Health Sciences Research, , MN, 55905, USA; Mayo Clinics Rochester , Department of Health Sciences Research, , MN, 55905, USA Key Laboratory of Agro-Products Processing, Ministry of Agriculture and Rural Affairs, Institute of Food Science and Technology, Chinese Academy of Agricultural Sciences (CAAS), Beijing 100193, China College of Chemistry and Chemical Engineering, College of Life Science, Jiangxi Normal University, Nanchang, Jiangxi 330022, China W.R. Wiley Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99352, United States Department of Molecular Toxicology, Jiangsu Provincial Key Laboratories of Human Functional Genomics and Applied Toxicology, School of Public Health, Nanjing Medical University, Nanjing 210029, China. Contribution from the Department of Chemistry, Michigan Technological University, Houghton, Michigan 49931 Department of Toxicology and Cancer Biology, University of Kentucky College of Medicine, Lexington, Kentucky 40536; School of Public Health, Guangzhou Medical University, Guangzhou, Guangdong 511436, P.R. China State Key Laboratory of Biocontrol, Open Laboratory for Marine Functional Genomics of the State High-Tech Development Program, Guangdong Province Key Laboratory for Pharmaceutical Functional Genes, School of Life Sciences, Sun Yat-Sen University, Guangzhou, Guangdong 510006, People’s Republic of China; College of Chemistry; Chemical Engineering and Materials Science; Soochow University; Suzhou 215123; P. R. China Department of Vasculocardiology, The Affiliated Hospital of Southwest Medical University, Luzhou, China Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Research Center for Food Additive Engineering Technology, Laboratory of Molecular Sensory Science, Beijing Technology and Business University (BTBU), Beijing 100048, P. R. China School of Public Health, Peking University, Beijing 100191, China; School of Nursing, Peking University, Beijing 100191, China Department of Herpetology, Chengdu Institute of Biology, Chinese Academy of Sciences, No.9 Section 4, Renmin South Road, Chengdu, Sichuan 610041, People's Republic of China Department of Ultrasound, Zhongshan Hospital, Fudan University, Shanghai, 200032, P. R. China Department of Pathology Yantai Yuhuangding Hospital, Affiliated Hospital of Qingdao University Yantai Shandong People's Republic of China Division of Mechanics and Acoustic, National Institute of Metrology, Beijing 100013, China Department of Neurology, General Hospital of Ningxia Medical University, Yinchuan 750004, Ningxia, China Department of Laboratory Zhangjiagang Hospital of Traditional Chinese Medicine Zhangjiagang China Department of Pathology, Yantai Yuhuangding Hospital of Qingdao University, Yantai 264000, Shandong Province, China Department of Toxicology and Cancer Biology, and Center for Research on Environment Disease College of Medicine, University of Kentucky Lexington KY; School of Public Health Guangzhou Medical University Guangzhou Guangdong China Mayo Clinic, College of Medicine, Rochester, MN, USA. Innovation Research Center of Chiral Drugs, Institute for Advanced Study, Chengdu University, Chengdu 610106, China; National Engineering Research Center of Chiral Drugs, Chengdu Institute of Organic Chemistry, Chinese Academy of Sciences, Chengdu 610041, China; School of Pharmacy, Zunyi Medical University, Zunyi 563000, China Department of Burns and Plastic Surgery, The 7th People Hospital of Shanghai, Shanghai 200137, PR China. School of Pharmacy Fudan University Shanghai P. R. China Department of Pathology, Yuhuangding Hospital of Qingdao University, Yantai, P.R. China [email protected] [email protected]. Key Laboratory for Advanced Technologies of Materials; Ministry of Education; School of Material Science and Engineering; Southwest Jiaotong University; Chengdu 610031 Department of Radiotherapy, The First Affiliated Hospital of Hainan Medical University Department of Pulmonary and Critical Care Medicine, Peking University Third Hospital, Beijing, China; Institute of Medical Technology, Peking University Health Science Center, Beijing, China Materials Science & Engineering, National University of Singapore, 9 Engineering Drive 1, Singapore 117575, Singapore.; Singapore Synchrotron Light Source (SSLS), National University of Singapore, 5 Research Link, Singapore 117603, Singapore. Department of Cardiology, The General Hospital of Western Theater Command , Chengdu, Sichuan, PR China College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou, 215123, China Key Lab. for Advanced Technologies of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, PR China Department of Psychiatrics, Hunan Brain Hospital, Changsha, Hunan 410007, P.R. China Southwest Jiaotong University Key Laboratory for Advanced Technologies of Materials, Ministry of Education, School of Material Science and Engineering, , Chengdu 610031, People's Republic of China From the Departments of Ophthalmology and Singapore Synchrotron Light Source, National University of Singapore, Singapore 117603, Singapore Authors' Affiliations: Departments of 1Molecular Medicine, 2General Thoracic Surgery, 3Pulmonary and Critical Care Medicine, 4Health Sciences Research, and 5Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota; Authors' Affiliations: Departments of 1Molecular Medicine, 2General Thoracic Surgery, 3Pulmonary and Critical Care Medicine, 4Health Sciences Research, and 5Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota Department of Materials Science and Engineering National University of Singapore Singapore 117575 Singapore; Singapore Synchrotron Light Source (SSLS) National University of Singapore 5 Research Link Singapore 117603 Singapore School of Basic Medicine, Chengdu Medical College, Chengdu, Sichuan 610500, P.R. China Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA From the Departments of Medicine and Pharmacology (P.Y., H.K., B.D., T.Y., J.W., P.C.V., K.T.M., K.N., A.L.G., D.M.R.), Vanderbilt University School of Medicine, Nashville, Tenn; Cardiology Division (S.H.H.), Johann Wolfgang Goethe University, Frankfurt, Germany; National Cardiology Center (W.S.), Osaka, Japan; Department of Cardiology (P.J.S.), Policlinico S. Matteo, Istituto di Ricovero e Cura a Carattere Scientifico, Pavia, Italy; and Medtronic Inc (M.S.), Minneapolis, Minn. Jilin Provincial Precision Medicine Key Laboratory for Cardiovascular Genetic Diagnosis (Jilin Provincial Engineering Laboratory for Endothelial Function and Genetic Diagnosis of Cardiovascular Disease; Jilin Provincial Molecular Biology Research Center for Precision Medicine of Major Cardiovascular Disease; Jilin Provincial Cardiovascular Research Institute), Department of Cardiology, China–Japan Union Hospital of Jilin University, Changchun, China. Key Lab. for Advanced Technologies of Materials, Ministry of Education, School of Material Sciences and Engineering, Southwest Jiaotong University, Chengdu, Sichuan, P.R. China Department of Hematology, Peking University Third Hospital, Beijing 100191, China Department of Gynecology, First Affiliated Hospital Shihezi University Shihezi China; The NHC Key Laboratory of Prevention and Treatment of Central Asia High Incidence Diseases, First Affiliated Hospital Shihezi University Shihezi China State Key Laboratory for Manufacturing Systems Engineering, International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technologies, Collaborative Innovation Center of Suzhou Nano Science and Technology, Xi’an Jiaotong University 1 , Xi’an 710049, People’s Republic of China; School of Mechanical Engineering, Xi’an Jiaotong University 2 , Xi’an 710049, People’s Republic of China Key Laboratory of Grain and Oil Processing and Food Safety of Sichuan Province, College of Food and Bioengineering, Xihua University, Chengdu, 610039, China; Key Laboratory of Food Non-Thermal Technology, Engineering Technology Research Center of Food Non-Thermal, Yibin Xihua University Research Institute, Yibin, 644004, China Department of Vasculocardiology, Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, China Authors' Affiliations: Divisions/Departments of 1Epidemiology, 2Biomedical Statistics and Informatics, 3Medical Oncology, 4Pulmonary and Critical Care Medicine, 5Radiology, and 6Experimental Pathology and Laboratory Medicine, 7Department of Surgery, Mayo Clinic, Rochester, Minnesota; and 8Department of Respiratory Medicine, Jinling Hospital, Medical School of Nanjing University, Nanjing, PR China Xi'an Jiaotong University College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People's Republic of China. College of Food Engineering, Harbin University of Commerce, Harbin 150076, China School of Materials and Engineering, Nanjing Institute of Technology, Nanjing 211167, China Department of Clinical Laboratory, Tianjin Key Laboratory of Cerebral Vessels and Neural Degeneration, Tianjin Huanhu Hospital, Tianjin 300350, P.R. China Department of Internal Medicine and Cardiology, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China Faculty of Architecture and Urban Planning, Chongqing University, Chongqing 400045, China; Key Laboratory of New Technology for Construction of Cities in Mountain Area, Chongqing 400045, China Department of Gastrointestinal Surgery, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital (Eastern Hospital), Chengdu Department of Oncology; PLA Navy General Hospital; Beijing; P. R. China Department of Infectious Diseases, Affiliated Hospital of Zunyi Medical University, Zunyi 56300, China State Key Laboratory of Subtropical Silviculture, Bamboo Industry Institute, Zhejiang A&F University , Lin’an, Hangzhou, Zhejiang 311300, China Jilin Provincial Engineering Laboratory for Endothelial Function and Genetic Diagnosis of Cardiovascular Disease, Department of Cardiology, China-Japan Union Hospital of Jilin University Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4,1 and Faculty of Pharmaceutical Sciences, University of Toyama, Toyama 930-0194, Faculty of Agriculture, Iwate University, Morioka 020-8550, and Division of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo 060-0810, Japan Laboratory of Animal Cell Biology and Embryology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu Province, China The Singapore Synchrotron Light Source (SSLS) National University of Singapore Singapore 117603 Singapore Washington University School of MedicineSt. Louis, Missouri From the Department of Medicine and Pharmacology (T.Y., W.Z., P.Y., D.M.R.), Oates Institute for Experimental Therapeutics, Vanderbilt University School of Medicine, Nashville, Tenn; Institute of Life Science (S.-K.C., J.G.L.M., M.I.R.), School of Medicine, Swansea University, Swansea, United Kingdom; the Department of Molecular Medicine and Pathology (C.H.M., J.K.F.), Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand; Cardiac Inherited Disease Group (J.C., J.M.,... College of Chemistry; Chemical Engineering and Materials Science; Soochow University; Suzhou 215123; P R China Department of Chemistry, University of Missouri-Rolla, 142 Schrenk Hall, Rolla, Missouri 65409-0010, USA 2Mayo Clinic, Rochester, Minnesota; Authors' Affiliations: 1Department of Epidemiology, The University of Texas MD Anderson Cancer Center; 2Department of Pediatrics, Division of Hematology-Oncology, Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, Texas; 3Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, United Kingdom; 4Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut; 5Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts; 6Case Comprehensive Cancer Center, Case Western Reserve University School of Medicine, Cleveland, Ohio; 7The Neurological Institute of Columbia University; 8Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center; New York, New York; 9Cancer Control and Prevention Program, Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina; 10Cancer and Radiation Epidemiology Unit, Gertner Institute, Chaim Sheba Medical Center, Tel Hashomer; Department of Cancer Systems Imaging, University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA. Department of Pharmacy, Xinhua Hospital, Shanghai Jiaotong University Medical School, Ningbo University, Ningbo, Zhejiang 315211, China Department of Anesthesiology and Translational Neuroscience Center West China Hospital, Sichuan University Chengdu China; Department of Anesthesiology Three Gorges Central Hospital of Chongqing Chongqing China The Center for Biomedical Research, Key Laboratory of Organ Transplantation, Ministry of Education, NHC Key Laboratory of Organ Transplantation, Key Laboratory of Organ Transplantation, Chinese Academy of Medical Sciences, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China State Key Laboratory for Manufacturing Systems Engineering, International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technologies, Xi'an Jiaotong University (Yantai) Research Institute for Intelligent Sensing Technology and System Xi'an Jiaotong University Xi'an 710049 China; School of Mechanical Engineering Xi'an Jiaotong University Xi'an 710049 China; Shandong Laboratory of Yantai Advanced Materials and Green Manufacturing Yantai 265503 China Department of Neurobiology and State Key Laboratory of Medical Neurobiology, School of Basic Medical Sciences Shanghai Medical College, Fudan University Shanghai 200032 China Authors' Affiliations: 1Department of Epidemiology, The University of Texas, MD Anderson Cancer Center, Houston, Texas; 2University of Cincinnati, Cincinnati, Ohio; 3National Human Genome Research Institute, Baltimore, Maryland; 4Mayo Clinic College of Medicine, Rochester, Minnesota; 5Washington University, St. Louis, Missouri; and 6Karmanos Cancer Institute, Wayne State University, Detroit, Michigan Department of Atmospheric Sciences Texas A&M University College Station Texas USA The Third Hospital of Peking University, Peking University Eye Center, Beijing 100083, China. Department of Toxicology and Cancer Biology, University of Kentucky, Lexington, Kentucky 40536 Department of Neurobiology, Third Military Medical University, Chongqing 400038, China. Department of Medical Oncology, Sixth Medical Center of PLA General Hospital, Beijing, China School of Materials Science and Engineering, University of Science and Technology Beijing, Beijing 100083, China Institute of Advanced Materials (IAM), Key Laboratory for Organic Electronics & Information Displays (KLOEID), Nanjing University of Posts & Telecommunications (NUPT), Nanjing 210023, China; Department of Mechanics and Aerospace Engineering, Southern University of Science and Technology (SUSTech), Shenzhen 518055, China Department of Pharmacy, Peking University Third Hospital, Beijing, China; Therapeutic Drug Monitoring and Clinical Toxicology Center, Peking University, Beijing, China The State Key Laboratory for Mechanical Manufacturing Systems Engineering, Xi’an Jiaotong University, Xi’an 710054, China Institute of Image Processing and Pattern Recognition, Shanghai Jiao Tong University, Shanghai 200240, China. [email protected] Authors' Affiliations: 1The Dan L. Duncan Cancer Center, Baylor College of Medicine; Departments of 2Genitourinary Medical Oncology and 3Epidemiology, The University of Texas MD Anderson Cancer Center, Houston, Texas; and 4The Mayo Clinic, Rochester, Minnesota First Affiliated Hospital of Chongqing Medical University, Chongqing, China 6Mayo Clinic Cancer Center, Rochester, Minnesota. Department of Obstetrics and Gynecology, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, China. The Center for Biomedical Research, Key Laboratory of Organ Transplantation, Ministry of Education, Key Laboratory of Organ Transplantation, Ministry of Health, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Ave, Wuhan, 430030, China. [email protected]. Key Laboratory of Industrial Ecology and Environmental Engineering, Ministry of Education, Dalian University of Technology, Dalian 116024, China. [email protected] Biological Sciences Division, Environmental Molecular Sciences Laboratory, and Chemical and Material Sciences Division, Pacific Northwest National Laboratory, 902 Battlelle Boulevard, Richland, Washington 99352, United States, Department of Chemistry, University of Michigan, 930 North University Avenue, Ann Arbor, Michigan 48109-1055, United States, and Department of Chemistry, University of California—Davis, One Shields Avenue, Davis, California 95616, United States College of Architecture and Environment, Sichuan University, Chengdu, China School of Life Sciences; Jilin University; Changchun, PR China Key Laboratory for Advanced Technologies of Materials, Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University, Chengdu 610031, P.R. China Department of Emergency, General Hospital of Ningxia Medical University, Niangxia 750004, China Department of Epidemiology, Mayo Clinic, Scottsdale, AZ Singapore Synchrotron Light Source (SSLS), National University of Singapore, 5 Research Link, Singapore 117603, Singapore Authors' Affiliations: 1Division of Pulmonary and Critical Care Medicine, 2Department of Health Sciences Research, 3Department of Laboratory Medicine and Pathology, 4Gene Expression Core, Advanced Genome Technology Center, Mayo Clinic, Rochester, Minnesota; 5Department of Biochemistry and Cell Biology, Kyungpook National University, Daegu, South Korea; and 6the Laboratory of Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland; Authors' Affiliations: 1Division of Pulmonary and Critical Care Medicine, 2Department of Health Sciences Research, 3Department of Laboratory Medicine and Pathology, 4Gene Expression Core, Advanced Genome Technology Center, Mayo Clinic, Rochester, Minnesota; 5Department of Biochemistry and Cell Biology, Kyungpook National University, Daegu, South Korea; and 6the Laboratory of Carcinogenesis, National Cancer Institute, National Institutes of Health, Bethesda, Maryland EMSL; Pacific Northwest National Laboratory; Richland; USA; Theoretical Division Department of Respiratory Medicine, People's Hospital Affiliated to Fujian University of Traditional Chinese Medicine, Fuzhou, Fujian 350001, P.R. China State Key Laboratory of Organometallic Chemistry; Center for Excellence in Molecular Synthesis; Shanghai Institute of Organic Chemistry; University of Chinese Academy of Sciences; Chinese Academy of Sciences Department of Cardiology, Baoji People’s Hospital, Baoji 721006, China Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St. Louis, Missouri 63110 Laboratory of Radiation Medicine, West China Second University Hospital, Sichuan University, Chengdu 610041, China Department of Neurobiology , Army Medical University (Third Military Medical University) , Chongqing 400038 , China Department of Medicine, Jinggangshan University, Ji’an, China Mayo Clinic Cancer Center; Rochester MN College of Agriculture, Guangxi University, Nanning 530004, People’s Republic of China Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, WA 99352; Laboratory of Animal Cell Biology and Embryology College of Veterinary Medicine Nanjing Agricultural University Nanjing Jiangsu 210095 China Department of Cardiology China‐Japan Union Hospital of Jilin University Changchun China; Jilin Provincial Key Laboratory for Genetic Diagnosis of Cardiovascular Disease Changchun Jilin Province China Department of Gastrointestinal Surgery, Zhongnan Hospital of Wuhan University, Wuhan, China; Hubei Cancer Clinical Study Center & Hubei Key Laboratory of Tumor Biological Behaviors, Wuhan, China MS B221, T-1 Physics and Chemistry of Materials Los Alamos National Laboratory Los Alamos New Mexico 87545 USA Materials Science and Engineering National University of Singapore 9 Engineering Drive 1 Singapore 117575 Singapore; Singapore Synchrotron Light Source (SSLS) National University of Singapore 5 Research Link Singapore 117603 Singapore Key Laboratory for Advanced Technologies of Materials School of Material Science and Engineering, Southwest Jiaotong University, Ministry of Education Chengdu People's Republic of China 8Mayo Clinic, Scottsdale, Arizona. Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, P.O. Box 999, Richland, Washington 99352, United States Department of Orthopedics, Wuhan Red Cross Hospital, Wuhan Hubei, 430022, P.R.China. From the Department of Cardiology (L.C., G.M.D.F., A.V., P.J.S.), University of Pavia, and IRCCS Policlinico S. Matteo, Pavia; Molecular Cardiology Laboratory (L.C., R.I., M.P., C.F., P.J.S.), IRCCS Policlinico S. Matteo, Pavia, Italy; and the Departments of Pharmacology (A.L.L., P.Y., D.M.R., A.L.G.) and Medicine (D.M.R., A.L.G.), Vanderbilt University, Nashville, Tennessee. Authors' Affiliations: 1Washington University School of Medicine, St. Louis, Missouri; 2Mayo Clinic, Rochester, Minnesota; 3M.D. Anderson Cancer Center, Houston, Texas; 4Karmanos Cancer Institute, Detroit, Michigan; 5University of Cincinnati, Cincinnati, Ohio; 6University of Texas Southwestern Medical Center, Dallas, Texas; 7University of Toledo College of Medicine, Toledo, Ohio; 8Louisiana State University Health Science Center, New Orleans, Louisiana; 9National Cancer Institute, Bethesda, Maryland; and 10National Human Genome Research Institute, Baltimore, Maryland School of Material Science and Engineering, University of Jinan, 250022, Jinan, P. R. China School of Pharmacy, Fudan University, 138 Yixueyuan Road, Shanghai 200032, China, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, 18 Tianshui Middle Road, Lanzhou 730000, China, and Graduate University of Chinese Academy of Sciences, 19 Yuquan Road, Beijing 100049, China Department of Psychiatry, Brain Hospital of Hunan Province, Changsha, Hunan 410007, P.R. China 4Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota; and Chinese Academy of Sciences Department of Veterinary Microbiology, Western College of Veterinary Medicine, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4, Canada; Saskatchewan Health Services Utilization and Research Commission, University of Saskatchewan, Saskatoon, Saskatchewan S7N 5B4, Canada Instrumental Analysis Centre, School of Pharmacy Fudan University Shanghai 201203 P.R. China National Key Laboratory of Green Pesticide, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education, Center for R&D of Fine Chemicals of Guizhou University, Guiyang, 550025, China Key Lab. for Advanced Technologies of Materials (Ministry of Education) School of Material Science and Engineering; Southwest Jiaotong University; Chengdu 610031; PR China Cardiology Department, China-Japan Union Hospital of Jilin University; Jilin Provincial Cardiovascular Research Institute; Jilin Provincial Key Laboratory for Genetic Diagnosis of Cardiovascular Disease From the Department of Ophthalmology, Duke University, Durham, North Carolina; and the Department of Cardiology, China‑Japan Union Hospital of Jilin University, Jilin Provincial Precision Medicine Key Laboratory for Cardiovascular Genetic Diagnosis, Jilin Provincial Engineering Laboratory for Endothelial Function and Genetic Diagnosis of Cardiovascular Disease, Jilin Provincial Molecular Biology Research Center for Precision Medicine of Major Cardiovascular Disease, Jilin Provincial Cardiovascular Research Institute, Changchun, Jilin 130028, P.R. China Authors' Affiliations: 1Department of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, Nanjing, P.R. China and 2Division of Epidemiology and Cancer Center, 3Department of Radiology, 4Division of Medical Oncology, 5Division of Biomedical Statistics and Informatics, 6Department of Information Technology, and 7Division of Pulmonary and Critical Care Medicine, Mayo Clinic, Rochester, Minnesota MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China. Department of Respiration Brain Hospital of Hunan Province Changsha China 3Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota. Authors' Affiliations: 1Department of Toxicology, Guangdong Provincial Key Laboratory of Food, Nutrition and Health, School of Public Health, Sun Yat-sen University, Guangzhou; 2Key Laboratory of Chemical Safety and Health, National Institute for Occupational Health and Poison Control, Chinese Center for Disease Control and Prevention, Beijing; and 3Department of Toxicology, Shenzhen Center for Disease Control and Prevention, Shenzhen, China Department of Pathology Sun Yat‐sen University Cancer Center Guangzhou 510060 Guangdong P. R. China Science Faculty, Chemistry Program, Key Laboratory of Chemical Biology and Traditional Chinese Medicine Research and Key Laboratory of Resource Fine-Processing and Advanced Materials of Hunan Province of MOE, College of Chemistry and Chemical Engineering; Hunan Normal University; Changsha Hunan 410081 China MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, Jiangsu Province, China Department of Department of Quantitative Health Science Mayo Clinic Rochester Minnesota USA Department of the Medical Oncology, The Eighth People’s Hospital of Shanghai, Shanghai, P.R. China Department of Atmospheric Sciences Texas A&M University College Station TX USA Department of Psychiatry, Brain Hospital of Hunan Province, Changsha, China Singapore Synchrotron Light Source (SSLS), National University of Singapore, 5 Research Link, 117603, Singapore College of Chemistry; Chemical Engineering and Materials Science; Soochow University; Suzhou 215123, China Department of Neurobiology, Chongqing Key Laboratory of Neurobiology Third Military Medical University Chongqing 400038 PR China National Key Laboratory of Optical Field Manipulation Science and Technology, Chinese Academy of Sciences, Chengdu 610209, China; Key Laboratory on Adaptive Optics, Institute of Optics and Electronics, Chinese Academy of Sciences, Chengdu 610209, China; Institute of Optics and Electronics, Chinese Academy of Sciences, Chengdu 610209, China National Laboratory of Color Science and Engineering, Department of Optical Engineering, Beijing Institute of Technology, Beijing 100081, China. [email protected] Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, School of Medicine, South China University of Technology, Guangzhou, Guangdong, China Department of Gynecology and Obstetrics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Obstetrics and Gynecology, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, China Institute of Biomaterials and Surface Engineering, Key Laboratory for Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, P.R. China Key Laboratory of Advanced Technology of Materials; Ministry of Education; School of Material Science and Technology of Southwest Jiaotong University; Chengdu 610031; PR China Division of Neonatology, General Hospital of Ningxia Medical University， Yinchuan 750004， China. Department of Liver Surgery, West China Hospital of Sichuan University/West China School of Nursing, Sichuan University, Chengdu, P.R. China. Advanced Research Initiative for Correlated-Electron Systems (ARiCES), Department of Physics, National University of Singapore, 2 Science Drive 3, Singapore 117551, Singapore Singapore Synchrotron Light Source (SSLS), National University of Singapore, 117603, Singapore Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA. [email protected] Department of Obstetrics and Gynecology, First Affiliated Hospital，School of Medicine, Shihezi University, Shihezi 832008, China. Department of Atmospheric Sciences, Texas A&M University, College Station, TX 77843, USA. Department of Cardiology Chongqing Kanghua Zhonglian Cardiovascular Hospital Chongqing China Theoretical Division, Center for Nonlinear Studies (CNLS), and Center for Integrated Nanotechnologies (CINT), Los Alamos National Laboratory, Los Alamos, New Mexico 87545 Key Laboratory of Animal Physiology and Biochemistry, Ministry of Agriculture, College of Veterinary Medicine Nanjing Agricultural University Nanjing PR China Key Laboratory of Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, China; School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, China National Engineering Laboratory for AIDS Vaccine, School of Life Sciences, Jilin University Changchun China Hubei University of Traditional Chinese Medicine, Hubei, Wuhan, China Department of Anesthesiology Tongji Hospital Tongji Medical College Huazhong University of Science and Technology Wuhan Hubei China Department of Cardiology, China‑Japan Union Hospital of Jilin University, Changchun, Jilin 130033, P.R. China Department of Geriatrics, The First People’s Hospital of Lianyungang, Lianyungang, Jiangsu, 222000, China Key Laboratory on Adaptive Optics, Institute of Optics and Electronics, Chinese Academy of Sciences, Chengdu 610209, China; Institute of Optics and Electronics, Chinese Academy of Sciences, Chengdu 610209, China Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA From the Department of Pharmacy, Xinhua Hospital, Shanghai Jiaotong University, Shanghai, China (P.Y., X.W., J.Z.); Center for Translational Medicine, Department of Medicine, Thomas Jefferson University, Philadelphia, PA (P.Y., X.W., B.Y., G-.X.Z.,L.Y., J.S.); and Centers of Metabolic Disease Research and Cardiovascular Research, Department of Pharmacology, Temple University School of Medicine, Philadelphia, PA (X-.F.Y.). The Key laboratory of Adaptive Optics Chinese Academy of Sciences Chengdu Sichuan 610209 China; Institute of Optics and Electronics Chinese Academy of Sciences Chengdu Sichuan 610209 China Department of Analytical Chemistry; China Pharmaceutical University; Nanjing 211198; China The Center for Biomedical Research, Key Laboratory of Organ Transplantation, Ministry of Education & Ministry of Health, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China Department of Neurology and Institute of Neurology Huashan Hospital, Shanghai Medical College, Fudan University Shanghai China Department of Epidemiology and College of Architecture and Environment, Sichuan University, Chengdu, 610065 Sichuan, China E-mail: [email protected]; [email protected] Laboratory of Radiation Medicine West China Second University Hospital Sichuan University Chengdu Sichuan P. R. China Institute for Chemical Carcinogenesis, Guangzhou Medical University, Guangzhou, Guangdong, China (mainland) College of Veterinary Medicine Nanjing Agricultural University Nanjing People's Republic of China Department of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China Sun Yat‐sen University Cancer Center State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine Guangzhou China; Department of Pathology Sun Yat‐Sen University Cancer Center Guangzhou China College of Agronomy, Key Laboratory of Southwestern Crop Genetic Resource and Improvement, Ministry of Education, Sichuan Agricultural University, Ya'an 625014, China. [email protected] Mayo Clinic, Rochester, MN Pacific Northwest National Laboratory, Richland, Washington 99352, United States Department of Pathology Yantai Yuhuangding Hospital, Qingdao University Yantai China †Department of Pathology, Immunology and Laboratory Medicine, College of Medicine, University of Florida, Gainesville, FL 32610 Department of Pathology and Laboratory Medicine, Western University, London, ON, Canada Center for Drug Evaluation， China Food and Drug Administration， Beijing 100022， China. School of Material Science and Engineering, University of Jinan, Jinan 250022, P. R. China The Affiliated Hospital of Jiangsu University, Zhenjiang 212001, China Department of Breast Medical Oncology, Cancer Hospital of Shantou University Medical College, Shantou 515031, PR China The State Key Laboratory for Manufacturing Systems Engineering, Xi’an Jiaotong University, Xi’an 710054, China MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu Province 210095, China Ningbo College of Health Sciences Ningbo 315100, China. Department of Endocrinology The Affiliated Changzhou No. 2 People's Hospital of Nanjing Medical University Changzhou China Key Lab. of Advanced Technology for Materials of Education Ministry; School of Materials Science and Engineering; Southwest Jiaotong University; Chengdu 610031; P. R. China Department of Anesthesiology and Divisions of Clinical Pharmacology and Genetic Medicine, Vanderbilt University, Nashville, TN 37232 State Key Laboratory for Manufacturing Systems Engineering, International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technologies, Collaborative Innovation Center of Suzhou Nano Science and Technology, Xi’an Jiaotong University 1 , Xi’an 710049, China; School of Mechanical Engineering, Xi’an Jiaotong University 2 , Xi’an 710049, China School of Material Science and Engineering, University of Jinan, Jinan, 250022, P. R. China Department of Gastroenterology, Foshan First People's Hospital The Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan 430030, China; The Center for Biotechnology and Genomic Medicine, Medical College of Georgia, 1120 15th Street, CA4098, Augusta, GA 30912, USA Institute of Biomaterials and Surface Engineering, Key Lab for Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, No. 111 of the North First Section of Second Ring Road, Chengdu, CN 610031, China Agricultural Experiment Station Zhejiang University Hangzhou China School of Basic Medical Sciences, Chengdu Medical College, Chengdu, 610041, Sichuan, China Department of General Surgery, Guangzhou Digestive Disease Centre, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China Key Laboratory of Animal Physiology and Biochemistry Ministry of Agriculture College of Veterinary Medicine Nanjing Agricultural University Nanjing China Division of Epidemiology Department of Health Sciences Research Mayo Clinic Rochester Minnesota Department of Cardiology, Affiliated Hospital of Jiangsu University, Zhenjiang, China; and Department of Radiation Oncology, Zhongshan Hospital, Fudan University, Shanghai 200032, P.R. China 2Division of Epidemiology, Department of Health Sciences Research; Department of Colorectal Surgery, General Hospital of Ningxia Medical University , Yinchuan , China Department of Statistics, The Chinese University of Hong Kong, Hong Kong, China Los Alamos National Laboratory, Los Alamos, New Mexico 87545, Department of Physics, University of Washington, Seattle, Washington 98195, Chemical Sciences Division and Advanced Light Source, Lawrence Berkeley National Laboratory, Berkeley, California 94720, and W.R. Wiley Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington 99352 Department of Anatomy, Third Military Medical University, Chongqing 400038. [email protected] College of Chemistry; Chemical Engineering and Materials Science; Soochow University; Suzhou 215123; PR China Chinese Academy of Sciences; University of Chinese Academy of Sciences Research Centre of Wetlands in Subtropical Region, Key Laboratory of Humid Sub-tropical Eco-geographical Process of Ministry of Education, School of Geographical Sciences, Fujian Normal Universities, Fuzhou 350007, China. [email protected] College of Food Science and Technology Guangdong Ocean University Zhanjiang China Department of Burns and Plastic Surgery, Third Xiangya Hospital of Central South University, Changsha, Hunan 410013, P.R. China State Key Laboratory of Organometallic Chemistry; Shanghai Institute of Organic Chemistry; University of Chinese Academy of Sciences; Chinese Academy of Sciences; Shanghai 200032 Department of Pharmacy, Xinhua Hospital, Shanghai Jiaotong University, Shanghai, China; and Department of Biological Sciences, University of Alberta, Edmonton, AB T6G 2E9, Canada.; Department of Laboratory Medicine, Saint John Regional Hospital, Saint John, NB E2L 4L2, Canada. Authors' Affiliations: 1Department of Radiobiology/Molecular Epidemiology Radiation Effects Research Foundation, Hiroshima, Japan; 2Laboratory of Human Carcinogenesis, 3Department of Cancer, Epidemiology and Genetics, National Cancer Institute, NIH, Bethesda, Maryland; 4Department of Surgery I, Nippon Medical School Hospital, Tokyo, Japan; 5Faculty of Health Sciences, University of Eastern Finland, Kuopio, Finland; 6Department of Biology, Beckman Research Institute at the City of Hope, Duarte, California; 7Molecular Pharmacology and Developmental Therapeutics, and the Cancer Center, 8Pulmonary and Critical Care Medicine, and 9Department of Health and Human Sciences Research, Mayo Clinic, Rochester, Minnesota Materials, Physics and Applications Division, Los Alamos National Laboratory, MS J514, Los Alamos New Mexico, 87545, and Theoretical Division, Los Alamos National Laboratory, MS B268, Los Alamos New Mexico, 87545 Department of Cardiology, China-Japan Union Hospital of Jilin University; Jilin Provincial Key Laboratory for Genetic Diagnosis of Cardiovascular Disease, Changchun School of Public Health, Institute for Chemical Carcinogenesis Guangzhou Medical University Guangzhou Guangdong China College of Architecture and Environment, Sichuan University, Chengdu, People’s Republic of China Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, Yunnan, China (mainland) Department of Hematology, The Third Hospital, Peking University, Beijing 100083, China. School of Chemical Engineering Anhui University of Science and Technology Huainan Anhui 232001 People's Republic of China; State Key Laboratory of Materials‐Oriented Chemical Engineering Nanjing University of Technology Nanjing 210009 China Department of Health Sciences Research, Mayo Clinic, Scottsdale, AZ, USA Materials, Physics and Applications Division, Los Alamos National Laboratory, MS J514, Los Alamos, New Mexico 87545, and Theoretical Division, Los Alamos National Laboratory, MS B268, Los Alamos, New Mexico 87545 Centre for Lipid Research, Key Laboratory of Molecular Biology for Infectious Diseases, Ministry of Education, Institute for Viral Hepatitis, Department of Infectious Diseases The Second Affiliated Hospital Chongqing Medical University Chongqing China Center for Reproductive Medicine Shandong Provincial Hospital Affiliated to Shandong University Jinan China; National Research Center for Assisted Reproductive Technology and Reproductive Genetics, Shandong University Jinan China; The Key Laboratory for Reproductive Endocrinology Shandong University, Ministry of Education Jinan China Hangzhou Dianzi University, No. 1158 Second Avenue, Xiasha District, Hangzhou, Zhejiang 310018, China Department of Laboratory, The First Affiliated Hospital of Bengbu Medical College, Bengbu, Anhui 233000, P.R. China Fujian Provincial Key Laboratory for Subtropical Resources and Environment, Fujian Normal University , Fuzhou, Fujian, China; Research Centre of Wetlands in Subtropical Region, Fujian Normal University , Fuzhou, Fujian, China Epidemiology‐Cancer Research 200 First St S.W. Rochester Minnesota 55905 Theoretical Division Los Alamos National Laboratory Los Alamos New Mexico 87545 United States School of Clinical Medicine, Ningxia Medical University, Yinchuan, China; Ningxia Human Stem Cell Institute, General Hospital of Ningxia Medical University, Yinchuan, China; Department of Neurosurgery, Ningxia Human Stem Cell Institute, General Hospital of Ningxia Medical University, Yinchuan, China Institute of Biomaterials and Surface Engineering, Key Laboratory for Advanced Technologies of Materials, Ministry of Education, Southwest Jiaotong University, Chengdu 610031, People’s Republic of China Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN 55905; Department of Health Sciences Research, Mayo Clinic, USA Department of Hematology, Lymphoma Research Center, Peking University Third Hospital, Beijing, People’s Republic of China Henan Province of Key Laboratory of New Optoelectronic Functional Materials, College of Chemistry and Chemical Engineering, Anyang Normal University, Anyang, Henan 455000, People's Republic of China Singapore Synchrotron Light Source (SSLS), National University of Singapore, 5 Research Link, 117603 Singapore Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MI, USA Department of Pharmacy, Peking University Third Hospital, Beijing, China Department of Clinical Pharmacy, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai 201203, P.R. China College of Veterinary Medicine Nanjing Agricultural University Nanjing P. R. China Guangdong Provincial Key Laboratory of Gastroenterology, Department of Gastroenterology, Nanfang Hospital Southern Medical University Guangzhou China Department of pharmacology, Guilin Medical College, Guilin 541004, China. [email protected] Division of Cardiology, China-Japan Union Hospital of Jilin University, Changchun, Jilin Province, China State Key Laboratory of Food Science and Technology Nanchang University Nanchang China Key Laboratory for Advanced Technologies of Materials Ministry of Education, School of Material Science and Engineering, Southwest Jiaotong University Chengdu 610031 People's Republic of China Department of Chemistry and Biochemistry, University of Notre Dame, Notre Dame, Indiana 46556, United States Pharmaceutical Analysis Center of Tianjin Institute of Medical and Pharmaceutical Sciences, 79 Duolun Road, Heping District, Tianjin 300020, China Department of Ophthalmology, Duke University Eye Center, Durham, North Carolina, United States Theory Division, Los Alamos National Laboratory, Los Alamos, NM 87545, USA. Zhejiang A&F University The State Key Laboratory of Subtropical Silviculture, Bamboo Industry Institute, , Hangzhou, 311300 Zhejiang , China Department of Operation Anaesthesiology, Jinan Central Hospital Department of Pharmacology, Vanderbilt University School of Medicine, Nashville, TN 37232, USA. Singapore Synchrotron Light Source, National University of Singapore, 5 Research Link, Singapore 117603, Singapore Guangdong Provincial Key Laboratory of Marine Pharmacy, Zhanjiang Ocean University, Zhangjiang 524025, P. R. China. Texas A&M University No. 923 Hospital of PLA Joint Logistics Support Force, Nanning, Guangxi, China College of Chemistry, Chemical Engineering and Materials Science, Soochow University, Suzhou 215123, P.R. China Theoretical Division T-1; Los Alamos National Laboratory; Los Alamos; USA Theoretical Division, MS B268, Los Alamos National Laboratory, Los Alamos, New Mexico 87544, Laboratoire de Pharmacochimie Moleculaire, UPR 421 du CNRS, Faculte de Pharmacie, 74, route du Rhin, B.P. 24, 67401 IIIkirch Cedex, France, and Department of Chemistry, Michigan Technological University, Houghton, Michigan 49931 Laboratory of Animal Cell Biology and Embryology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, China Department of Health Sciences Research, Mayo Clinic, Rochester, MN, USA. Division of Epidemiology and Cancer Center, Mayo Clinic, Rochester, Minnesota 55905, USA. [email protected] Division of Epidemiology, Department of Health Sciences Research, Mayo Clinic, Scottsdale, Arizona Authors' Affiliations: 1Division of Clinical Pharmacology, Department of Molecular Pharmacology and Experimental Therapeutics; Divisions of 2Epidemiology and 3Biomedical Statistics and Informatics, Department of Health Sciences Research; and 4Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota The Center for Biomedical Research, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1095 Jiefang Avenue, Wuhan, 430030, China Center for Biotechnology and Genomic Medicine, Medical College of Georgia, Augusta, Georgia Department of Hematology, The Third Hospital of Peking University, Beijing 100191, China. Department of Psychiatry, Brains Hospital of Hunan Province, Changsha, China Authors' Affiliations: Departments of 1Epidemiology, 2Thoracic/Head & Neck Medical Oncology, and 3Thoracic and Cardiovascular Surgery, The University of Texas MD Anderson Cancer Center, Houston; 4Hamon Center for Therapeutic Oncology Research, The University of Texas Southwestern Medical Center, Dallas, Texas; and 5Department of Health Sciences Research, Mayo Clinic College of Medicine, Rochester, Minnesota 4Department of Pathology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Esophageal Cancer Institute, Guangzhou, China. Institute for Chemical Carcinogenesis Guangzhou Medical University Xinzao Panyu District Guangzhou 511439 P. R. China Center for Reproductive Medicine Shandong University Jinan Shandong China; Key Laboratory of Reproductive Endocrinology of Ministry of Education Shandong University Jinan Shandong China; Shandong Key Laboratory of Reproductive Medicine Jinan Shandong China; Shandong Provincial Clinical Research Center for Reproductive Health Jinan Shandong China; Shandong Technology Innovation Center for Reproductive Health Jinan Shandong China Key Laboratory of Biomedical Polymers of Ministry of Education & College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, Hubei 430072, China State Key Laboratory of Organometallic Chemistry, Center for Excellence in Molecular Synthesis, Shanghai Institute of Organic Chemistry, University of Chinese Academy of Sciences, Chinese Academy of Sciences, 345 Lingling Lu, Shanghai 200032, China From the Department of Medicine (T.C.A., D.M.S., H.W., T.Y., L.H., J.S.L., B.L., P.Y.), Molecular Physiology (S.B.H., M.A.M.), and Biophysics (S.B.H., M.A.M.) and the Department of Pharmacology (D.M.R.), Vanderbilt University School of Medicine, Nashville, Tennessee. Cardiology Department, China-Japan Union Hospital of Jilin University, Changchun, China Department of Laboratory, First Affiliated Hospital, Bengbu Medical College, Anhui 233000, China. Department of Psychosomatic Diseases, Second People's Hospital of Hunan Province, Changsha 410007, Hunan Province, China. Sichuan Academy of Chinese Medicine Sciences Chengdu 610041, China. Department of Vasculocardiology, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan 646000, China College of Architecture and Environment; Sichuan University; Chengdu 610065; China School of Material Science and Engineering, University of Jinan, 250022 Jinan, P. R. China Department of Hematology,Peking University Third Hospital, Beijing 100191,China. Department of Obstetrics and Gynecology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, China; Department of Obstetrics and Gynecology, First Affiliated Hospital, School of Medicine, Shihezi University, Shihezi, China Department of Health Sciences Research, Mayo Clinic, Rochester, Minnesota 55905, USA. Los Alamos National Laboratory, Los Alamos, New Mexico 87545, United States Institute of Functional Nano & Soft Materials (FUNSOM) Jiangsu Key Laboratory for Carbon-Based Functional Materials and Devices Soochow University Suzhou 215123 China 13Department of Health Sciences Research, Mayo Clinic and Foundation, Rochester, Minnesota; Merck & Co., Inc., Kenilworth, NJ *Simmon’s Arthritis Research Center and Center for Immunology, University of Texas Southwestern Medical School, Dallas, TX 75390; and Department of Anatomy Faculty of Basic Medical Sciences Kunming Medical University Kunming China State Key Laboratory for Manufacturing Systems Engineering, International Joint Laboratory for Micro/Nano Manufacturing and Measurement Technologies, Xi'an Jiaotong University (Yantai) Research Institute for Intelligent Sensing Technology and System, Xi'an Jiaotong University, Xi'an 710049, China; School of Mechanical Engineering, Xi'an Jiaotong University, Xi'an 710049, China Department of Obstetrics and Gynecology, The First Affiliated Hospital of Jinan University, Guangzhou, China Health Research Institute National Institute of Advanced Industrial Science and Technology Midorigaoka Ikeda‐city Osaka 563‐8577 Japan; School of Material Science and Engineering University of Jinan 250022 Jinan People's Republic of China MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu Province, 210095, China Department of Laboratory Medicine, Nanjing Drum Tower Hospital, The Affiliated Hospital of Nanjing University Medical School , Nanjing, Jiangsu, China MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, Jiangsu, China; College of Animal Science and Technology, Nanjing Agricultural University, Nanjing 210095, Jiangsu, China Beijing Advanced Innovation Center for Food Nutrition and Human Health, Beijing Research Center for Food Additive Engineering Technology, Laboratory of Molecular Sensory Science, Beijing Technology and Business University (BTBU), Beijing 100048, China State Key Laboratory of Polymer Physics and Chemistry, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Graduate School of the Chinese Academy of Sciences, 5625 Renmin Street, Changchun 130022, People’s Republic of China Chemistry and Chemical Engineering Department, Suzhou University, 215006, Suzhou, China Department of Clinical Pharmacy Hubei No. 3 People's Hospital of Jianghan University Wuhan China Centre for Lipid Research & Chongqing Key Laboratory of Metabolism on Lipid and Glucose, Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, China Department of Horticulture, Northeast Agricultural University, Mucai 59, Xiangfang, Harbin 150030, People’s Republic of China The Fourth People’s Hospital of Wuhu, Wuhu, China Beijing Advanced Innovation Center for Food Nutrition and Human Health Laboratory of Molecular Sensory Science College of Food and Chemical Engineering Beijing Technology and Business University Beijing China College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, P.R. China School of Material Science and Engineering; University of Jinan; Jinan; P. R. China Department of Pathology and Laboratory Medicine Western University London Ontario Canada; Cytogenetics Laboratory, Molecular Diagnostics Division London Health Sciences Centre London Ontario Canada State Key Laboratory of Natural and Biomimetic Drugs, School of Pharmaceutical Sciences, Peking University, No.38 Xueyuan Road, Beijing 100191, China; Center for Drug Evaluation, China Food and Drug Administration, No.1 Fuxing Road, Beijing 100038, China 39Mayo Clinic Cancer Center, Rochester, Minnesota; Singapore Synchrotron Light Source; National University of Singapore; Singapore Department of Medical genetics & Division of Morbid Genomics, State Key Laboratory of Biotherapy, West China Hospital, Sichuan University College of Information Science and Engineering, Ningbo University, Ningbo 315211, Zhejiang, China Department of Cardiology, Rui Jin Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of China; and 2Mayo Clinic, Department of Health Sciences Research, Rochester, Minnesota. Instrumental Analysis Center, School of Pharmacy, Fudan University, Shanghai, 201203, P.R. China Pathology Authors' Affiliations: 1Washington University, St. Louis, Missouri; 2Karmanos Cancer Institute, Detroit, Michigan; 3University of Cincinnati, Cincinnati, Ohio; 4Mayo Clinic, Rochester, Minnesota; 5University of Texas Southwestern Medical Center, Dallas, Texas; 6University of Toledo College of Medicine, Toledo, Ohio; 7Louisiana State University Health Science Center, New Orleans, Louisiana; 8National Cancer Institute, Bethesda, Maryland; 9National Human Genome Research Institute, Baltimore, Maryland; and 10M. D. Anderson Cancer Center, Houston, Texas Singapore Synchrotron Light Source (SSLS), National University of Singapore, 5 Research Link, Singapore 117603 Department of Burns and Plastic Surgery, Nanjing Drum Tower Hospital, the Affiliated Hospital of Nanjing University Medical School, Nanjing, China Department of Ophthalmology, Duke University, Durham, North Carolina Department of Animal Nutrition and Feed Science, College of Animal Science and Technology, Huazhong Agricultural University, Wuhan 430070, China Email: [email protected]. Department of Clinical Laboratory Tianjin Huanhu Hospital, Tianjin Health Bureau Tianjin 300060 China College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, People’s Republic of China; College of Animal Science & Technology, Nanjing Agricultural University, Nanjing, People’s Republic of China Department of 1Health Sciences Research, Mayo Clinic College of Medicine, Rochester, MN, 55905, USA. [email protected] Alliance Statistics and Data Management Center, Mayo Clinic, Rochester, Minnesota School of Pharmacy and Bioengineering, Chengdu University The School of Public Health, Institute for Chemical Carcinogenesis, Guangzhou Medical University, Guangzhou, Guangdong 510182, People’s Republic of China Department of Quantitative Health Sciences, Mayo Clinic, Rochester, Minnesota, USA Laboratory of Animal Cell Biology and Embryology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing 210095, China; The Postdoctoral Research Station in Animal Science, College of Animal Science & Technology, Nanjing Agricultural University, Nanjing 210095, China MOE Joint International Research Laboratory of Animal Health and Food Safety, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China; College of Animal Science and Technology, Nanjing Agricultural University, Nanjing, Jiangsu 210095, China Department of Toxicology, School of medicine, Zhejiang University. Hangzhou 310058, China. Department of Pharmacy Peking University Third Hospital Beijing China; Therapeutic Drug Monitoring and Clinical Toxicology Center of Peking University Beijing China Laboratory of Animal Cell Biology and Embryology College of Veterinary Medicine Nanjing Agricultural University Nanjing 210095 China Key Laboratory of Grain and Oil Processing and Food Safety of Sichuan Province College of Food and Bioengineering Xihua University Chengdu China Beijing Advanced Innovation Center for Food Nutrition and Human Health; Beijing Research Center for Food Additive Engineering Technology; Laboratory of Molecular Sensory Science; Beijing Technology and Business University (BTBU); Beijing Department of Pathology and Laboratory Medicine Schulich School of Medicine and Dentistry Western University London Ontario Canada; Cytogenetics Laboratory London Health Sciences Centre London Ontario Canada Graduate School of Agriculture, Iwate University Sun Yat-sen University Cancer Center, Guangzhou, China Laboratory of Animal Cell Biology and Embryology, College of Veterinary Medicine, Nanjing Agricultural University, Nanjing, Jiangsu Province 210095, China Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Pittsburgh , Pittsburgh , PA, USA Singapore Synchrotron Light Source (SSLS) National University of Singapore 5 Research Link Singapore 117603 Singapore School of Material Science and Engineering, University of Jinan, 250022, Jinan, China The Affiliated Hospital of Ningbo University, Ningbo, Zhejiang 315020, People's Republic of China; Zhejiang Provincial Key Laboratory of Pathophysiology, School of Medicine, Ningbo University, Ningbo, Zhejiang 315211, People's Republic of China School of Chemistry and Chemical Engineering, Sun Yat-sen University, Guangzhou 510275, China. Department of 3rd Neurosurgery, Brains Hospital of Hunan Province Changsha, China. Department of Cardiology, The First Affiliated Hospital of Kunming Medical University, Kunming, China Departments of aOphthalmology, Department of General Surgery, Guangzhou Digestive Disease Center, Guangzhou First People's Hospital, Guangzhou Medical University, Guangzhou, Guangdong 510180, P.R. China Department of Clinical Laboratory Tianjin Huan Hu Hospital Tianjin 300060 China; Tianjin Key Laboratory of Cerebral Vessels and Neural Degeneration Tianjin 300060 China Shanghai Research Center for Model Organisms, Shanghai 201203, China |
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