http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID270803
Outgoing Links
| Predicate | Object |
|---|---|
| abstract | Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 3. STKs catalyze the transfer of the gamma-phosphoryl group from ATP to serine/threonine residues on protein substrates. TAO3 is also known as JIK (c-Jun N-terminal kinase inhibitory kinase) or KFC (kinase from chicken). It specifically activates JNK, presumably by phosphorylating and activating MKK4/MKK7. In Saccharomyces cerevisiae, TAO3 is a component of the RAM (regulation of Ace2p activity and cellular morphogenesis) signaling pathway. TAO3 is upregulated in retinal ganglion cells after axotomy, and may play a role in apoptosis. TAO proteins possess mitogen-activated protein kinase (MAPK) kinase kinase activity. MAPK signaling cascades are important in mediating cellular responses to extracellular signals. The TAO3 subfamily is part of a larger superfamily that includes the catalytic domains of other STKs, protein tyrosine kinases, RIO kinases, aminoglycoside phosphotransferase, choline kinase, and phosphoinositide 3-kinase. |
| title | STKc_TAO3 |
| isDiscussedBy | http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18652742 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/23293114 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9243134 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/15952651 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/9776540 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/18601718 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/21320551 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16661620 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24036701 http://rdf.ncbi.nlm.nih.gov/pubchem/reference/16580781 |
| type | http://purl.obolibrary.org/obo/SO_0000417 |
Incoming Links
| Predicate | Subject |
|---|---|
| has component | http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCNP_057365 http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ9H2K8 |
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