http://rdf.ncbi.nlm.nih.gov/pubchem/conserveddomain/PSSMID438998

Outgoing Links

Predicate Object
abstract BRcat domain found in HOIL-1-interacting protein (HOIP) and similar proteins. HOIP, also called RING finger protein 31 (RNF31) or zinc in-between-RING-finger ubiquitin-associated domain protein, together with HOIL-1 and SHARPIN, forms the E3-ligase complex (also known as linear-ubiquitin-chain assembly complex LUBAC) that regulates NF-kappaB activity and apoptosis. It also interacts with the atypical mammalian orphan receptor DAX-1, trigger DAX-1 ubiquitination and stabilization, and participate in repressing steroidogenic gene expression. HOIP contains three Npl4 zinc fingers, a central ubiquitin-associated (UBA) domain responsible for interaction with the N-terminal ubiquitin-like domain (UBL) of HOIL-1L, an RBR domain, and a C-terminal linear chain determining domain (LDD). The RBR domain was previously known as RING-BetweenRING-RING domain or TRIAD [two RING fingers and a DRIL (double RING finger linked)] domain. Based on current understanding of the structural biology of RBR ligases, the nomenclature of RBR has been changed to RING1-BRcat (benign-catalytic)-Rcat (required-for-catalysis) recently. The RBR domain uses an auto-inhibitory mechanism to modulate ubiquitination activity, as well as a hybrid mechanism that combines aspects from both RING and HECT E3 ligase functions to facilitate the ubiquitination reaction. This model corresponds to the BRcat domain of HOIP and similar proteins that adopt the same fold as the Rcat domain while lacking the catalytic cysteine residue and ubiquitination activity.
title BRcat_RBR_HOIP
isDiscussedBy http://rdf.ncbi.nlm.nih.gov/pubchem/reference/25535333
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30948587
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/2448819
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/24831737
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/11937734
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30948593
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/13930473
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/30948594
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/8619373
http://rdf.ncbi.nlm.nih.gov/pubchem/reference/29600951
type http://purl.obolibrary.org/obo/SO_0000417

Incoming Links

Predicate Subject
has component http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ96EP0
http://rdf.ncbi.nlm.nih.gov/pubchem/protein/ACCQ924T7

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