| abstract |
Oxygenated esters of 4-substituted-phenylamino-benzhydroxamic acid derivatives of formula (1). Pharmaceutical compositions and methods for use Claim 1: A compound characterized in that it is of formula (1), wherein: W is as shown in structures (2); R2 is H, methyl, F or Cl, R3 is H or F; R4 is C1-6 alkyl, C2-4 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, - (CH2) -C3-6cycloalkyl, -O- (C1-4 alkyl), -S- (C1-2 alkyl) , -SO2CH3, -SO2NR6R7, -CsC- (CH2) nNH2, C = C (CH2) nOH, -C = C- (CH2) nNH2, - (CH2) mNH2, - (CH2) mNHCH3, - (CH2) mN (CH3) 2, (CH2) mOR8, (CH2) qCF3, -CsCCF3, -CH = CHCF3, -CH2CHCF2 or -CH = CF2, in which C1-6 alkyl and C2-6 alkynyl are optionally substituted with between 1 and 3 substituents selected from hydroxy and alkyl; m is 1 to 4, n is 1 to 2; q is 0 to 2; R5 is H or Cl; R6 and R7 are each independently H, methyl, or ethyl; R8 is independently methyl or ethyl; and its pharmaceutically acceptable salts. |