http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-056874-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0a9e6421e9257148abad101e1ce6c162 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4375 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 |
| filingDate | 2006-10-18^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_51c2ac53c549d83fca2c9e15326da11c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f5271f83c7293a6ca03552b938d7543a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_121926c0ab1c3c37795c4fe4c4227c2a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0b7a4863d0c9a0b1498faaddcb407c9c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2c6b20ffc0a201e3179b83f2d889d57d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_650673e59b62a050ce66c4d24194628e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6d40c129865b9b550a654c81d56375de |
| publicationDate | 2007-10-31^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-056874-A1 |
| titleOfInvention | DERIVATIVES OF 6- HETEROARILPIRIDOINDOLONA, ITS PREPARATION AND ITS APPLICATION IN THERAPEUTICS |
| abstract | Process of preparation and therapeutic application in proliferation of tumor cells. Claim 1: Compound that responds to formula (1), wherein R1 represents a hydrogen atom, a C1-4 alkyl group, CN, CF3 or CHF2; R2 represents a hydrogen atom or a C1-4 alkyl group; R3 represents a phenyl unsubstituted or substituted once or several times with substituents independently selected from a halogen atom, a C1-4 alkyl group, or a C1-4 alkoxy group; R4 represents a heterocyclic radical chosen from those in the group of formulas (2); R5 represents a hydrogen atom, a halogen atom, a C1-4 alkyl group or a C1-4 alkoxy group; R6 is chosen from a hydrogen atom, a group -SO2-R12, a C1-6 alkyl group, mono- or perfluoro C1-6 alkyl, a group - (CH2) n-NR8R9, a group - (CH2) n-NH -CO-C1-4 alkyl, a group - (CH2) n-NH-SO2-C1-4 alkyl, a group - (CH2) n-NH- (CH2) m-NR8R9, a group - (CH2) n - NH- (CH2) m-OR10, a group - (CH2) nO- (CH2) m - NR8R9, a group - (CH2) nO- (CH2) mO-C1-4 alkyl, a group - (CH2) nHal, a C1-6-O-R10 alkyl group, a -CO2- (CH2) mO-R10 group, a group - (CH2) n-COOR11; a C1-6 alkylcarbonyl, mono- or perfluoro C1-6 alkylcarbonyl, CO-NH-R10, -CO-C1-6-O-C1-4 alkyl group; R7 is chosen from the hydrogen atom, a C1-6 alkyl group, mono- or perfluoro C1-6 alkyl, a group - (CH2) n-NR8R9, a group - (CH2) n-NH-CO-C1-4 alkyl , a group - (CH2) n-NH-SO2-C1-4 alkyl, a group - (CH2) n-NH- (CH2) m-NR8R9, a group - (CH2) n-NH- (CH2) m- OR10, a group - (CH2) nO- (CH2) m-NR8R9, a group - (CH2) nO- (CH2) mO-C1-4alkyl, a group - (CH2) nHal, a group- C1-6alkyl -O-R10, a group -CO2- (CH2) m -O-R10, a group - (CH2) n-COOR11; a C1-6 alkylcarbonyl, mono- or perfluoro C1-6 alkylcarbonyl, CO-NH-R10, -CO-C1-6-O-C1-4 alkyl group; R8 and R9 each independently represent each other a hydrogen atom or a C1-4 alkyl group; or R8 and R9 together with the nitrogen atom to which they are attached constitute a heterocyclic radical chosen from pyrrolidin-1-yl, piperidin-1-yl, morpholin-4-yl or piperazinyl optionally substituted on its second nitrogen atom; R 10 represents a hydrogen atom, a C 1-4 alkyl group, a C 1-4 alkylcarbonyl group, a C 3-6 cycloalkylcarbonyl group, a C 3-6 cycloalkyl C 1-6 alkylcarbonyl group, a C 3-6 cycloalkyl group, a group heterocycle C5-6 alkyl, a mono- or perfluoro C1-6 alkyl group or a C3-6 cycloalkyl C1-4- group; R11 represents a hydrogen atom or a C1-6 alkyl group; R12 represents a C1-6 alkyl group, a mono- or perfluoro C1-6 alkyl group, a cycloalkyl group, a cycloalkylalkyl group or a C1-6-O-C1-4 alkyl group; m is 1 or 2; n is 0, 1 or 2; Hal represents a halogen atom; in the base or salt state of addition to an acid, as well as in the state of hydrate or solvate. |
| priorityDate | 2005-10-20^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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