http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-060050-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8cdf03e8fb140a101ff7f9de9652c5fe |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 |
| filingDate | 2007-03-21^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_848a516fd6ddfa033b118990c0d19eea http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5b0555063504b94e815941cd39623950 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cae93310fb0c27dc0274817b9d2536dc http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6f9e0b3bb0cd89e51035efa21a1a6b63 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e57665997c0a71c4af2738a2471dc65a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5852d5e9ec83f83c53a3701757952e8f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e0a2ea5d0a81b23c0590c4ef53b20c31 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e726551f7348beb4099e49b3f65bd822 |
| publicationDate | 2008-05-21^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-060050-A1 |
| titleOfInvention | MODULATING COMPOUNDS OF THE S1P RECEIVER AND USE OF THE SAME |
| abstract | Compound, pharmaceutical composition, method to treat cancer, autoimmune diseases, diabetes, lupus. Claim 1: A compound characterized in that it responds to formula (1) or salts acceptable for pharmaceutical use thereof; where, p and q are independently 0, 1, 2, 3 or 4; Z is O, NR2, S, S (O), S (O) 2, S (O) 2NR2, (CR3R4) n, C = O, C = S, C = N-R2 or a direct link; n is 0, 1, 2, 3 or 4; R1 is C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, C1-5 alkoxy, aryl or heteroaryl; R2 is hydrogen, hydroxy, S (O) 2, C = O, C = S, C = NH, C1-6 alkyl, C1-5 alkoxy, C1-5 alkylthio, halogen substituted C1-6 alkyl, C1- alkoxy 5 substituted with halogen, aryl, or heteroaryl; R3 and R4 are independently hydrogen, halo, hydroxyl, cyano, C1-6 alkyl, C1-5 alkoxy, C1-5 alkylthio, halogen substituted C1-6 alkyl, halogen substituted aryl, C1-5 alkoxy, or heteroaryl ; or R3 and R4, taken together, can form C = O; X is WC (O) OR5a, WP (O) R5bR5c, WS (O) 2OH, WS (O) 2NH2, WCONHSO3H or 1H-tetrazol-5-yl; W is a direct bond, O or C1-4 alkylene optionally substituted with one or more of halo, hydroxy, cyano, amino, alkylamino, arylamino, heteroarylamino, C1-4 alkoxy, or CO2H; R5a is hydrogen or C1-4 alkyl; R5b and R5c are independently hydrogen, hydroxyl, C1-4 alkyl, or C1-4 alkyl substituted with halogen; Y is a link or compound of the group of formulas (2); Q is a direct link, C = O, C = S, SO2, C (O) NR9, or (CR9R10) m; m is 0, 1, 2 or 3; R6 and R7 are independently hydrogen, halo, hydroxyl, cyano, C1-6 alkyl, C1-5 alkylthio, C1-5 alkoxy, C1-6 alkyl substituted by halogen or C1-5 alkoxy substituted by halogen; or R6 and R7 can be taken together with the atoms to which they are attached to form a 4- to 7-membered ring, or R6 is an alkylene group with the omega end of said alkylene group attached to ring A; R8 is hydrogen, halogen, hydroxyl, amino, cyano, C1-6 alkyl, C1-5 alkylthio, C1-5 alkoxy, C1-6 alkyl substituted by halogen, or C1-5 alkoxy substituted by halogen; R9 and R10 are independently hydrogen, halo, hydroxyl, cyano, C1-6 alkyl, C1-5 alkoxy, C1-5 alkylthio, halogen substituted C1-6 alkyl, halogen substituted C1-5 alkoxy, or -CO2R5a; A is aryl or heteroaryl, any of which may be optionally substituted with 1, 2 or 3 substituents selected from the group consisting of halo, hydroxyl, cyano, C1-6 alkyl, C1-5 alkylthio, C1-5 alkoxy, C1- alkyl 6 substituted with halogen, and C1-5 alkoxy substituted with halogen; B has the formula (3) in which, the asterisks indicate the point of attachment in the formula (1); n is 1 or 2; U is CH2, C (H) CH3, C (CH3) 2, C (H) (CF3), C (CF3) 2, or C (= O); and V is C (= O), C (= S), S, S (= O) or S (= O) 2. |
| priorityDate | 2006-03-21^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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