http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-067772-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-80 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-82 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07C233-66 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D235-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-20 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-24 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-36 |
| filingDate | 2008-08-01^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e97605457769fa6b183ccfe412c1dad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cf6c9f26a5b80865f5e8a8e16bf9da7e http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_423391ae9c312a6da87d7a66e0bc7311 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_cfea3b2a3effe615be00da52332d12f7 |
| publicationDate | 2009-10-21^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-067772-A1 |
| titleOfInvention | PIPERAZINIC DERIVATIVES OF NICOTINAMIDE, MEDICINES CONTAINING THEM, PROCESS TO PREPARE THEM AND USES OF THE SAME FOR THE TREATMENT OF ASSOCIATED DISORDERS TO THE NERVOUS SYSTEM, CARDIOVASCULAR AND / OR METABOLIC DISORDERS. |
| abstract | The invention relates to a compound of the formula 1: wherein R1 is hydrogen, halogen, lower alkyl, lower alkoxy, lower alkyl substituted by halogen, -O- (CH2) p-aryl or aryl; R2 is halogen, lower alkyl substituted by halogen, NR'R '', (CH2) p-heteroaryl or is -O-heterocycloalkyl, the substitution of the heteroaryl or heterocycloalkyl is lower alkyl; R '/ R' 'independently of each other is hydrogen, - (CH2) pO-lower alkyl, - (CH2) p-aryl optionally substituted, - (CH2) p-heteroaryl, - (CH2) p-heterocycloalkyl, or R 'and R' 'together with the N atom to which they are attached can form a heterocycloalkyl moiety optionally substituted by lower alkyl, -CH2-cycloalkyl, -s (O) 2CH3, - (CH2) pO-lower alkyl or substituted aryl , the substitution of the aryl is lower alkyl or lower alkoxy; W is phenyl, benzo [1,3] dioxolyl, pyridin-2-, -3- or -4-yl, indolyl or cycloalkyl; L is -CH2-, -CH (CH3) -, -CH2CH2-, -CH2CH (CH3) -, or CH2CH2CH2-; X is N or CH; n is the number 1 or 2; in case n is the number 2, R1 can be the same or different; or is the number 1 or 2; in the case that is number 2, R2 may be the same or different; p is the number 0, 1, 2 or 3, or a pharmaceutically acceptable acid addition salt thereof, with the exception of the following compounds: 6- (4-methyl-piperazin-1-yl) -N-phenethyl- nicotinamide (CAS 199478-31-4) N- (3,4-dichloro-benzyl) -3-fluor-benzamide (CAS 424815-98-5) N- (4-chloro-benzyl) -3-fluor-benzamide ( CAS 544661-83-8) N- (3-Chloro-benzyl) -3-fluor-benzamide (CAS 796051-07-5) and N-phenethyl-6-phenylamino-nicotinamide (CAS 571913-74-1) It has found that the compounds of formula 1 have good affinity with receptors associated with trace amines (TAAR), especially with TAAR1. The compounds can be used for the treatment of depression, anxiety disorders, bipolar disorder, attention deficit hyperactivity disorder (ADHD), stress-related disorders, psychotic disorders such as schizophrenia, neurological diseases such as Parkinson's disease, neurodegenerative disorders such as Alzheimer's disease, epilepsy, migraine, hypertension, substance abuse and metabolic disorders such as eating disorders, diabetes, diabetic complications, obesity, dyslipidemia, disorders of energy consumption and assimilation, disorders and malfunction of body temperature, homeostasis, sleep and circadian rhythm disorders and cardiovascular disorders. |
| priorityDate | 2007-08-03^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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