http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-076418-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_0e61263b84630539d1fc5281e3bd9ac4 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_1b2710fc436b8878c41e7b12250bba5a |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H15-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P7-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07H19-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D251-16 |
| filingDate | 2010-04-26^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3bad684861af8d69f764748cc83a5e6c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1f42b65aceba0ecd98e0c97c1af75ae7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e92d0139151e5403e7f5c60f6f95cc2f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_457cc37c58dd9299d93537ff8f8deb61 |
| publicationDate | 2011-06-08^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-076418-A1 |
| titleOfInvention | DECITABIN PREPARATION |
| abstract | Processes to prepare and purify decitabine and processes to prepare a crystalline form of decitabine. Pure decitabine Claim 1: A process for preparing decitabine, characterized in that it comprises a) silylating 5-azacytosine in a nitrile solvent to produce a compound of formula (1) wherein each R is independently an optionally substituted C1-6 alkyl group; b) bonding the compound of formula (1) with between about 0.9 and about 1.2 molar equivalents of a compound of formula (2) per molar equivalent of the compound of formula (1) where R1 represents an alkyl group having between 1 and 6 carbon atoms, and where each R2 is independently an optionally substituted acyl or aryl group, in the presence of between about 1 and about 1.2 molar equivalents of a non-metallic Lewis acid per molar equivalent of the compound of formula (1 ), and with an organic solvent, to provide a compound enriched in the anomer b of formula (3); and c) deprotecting the compound of formula (3) to obtain decitabine. |
| priorityDate | 2009-04-27^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
Incoming Links
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