http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-078178-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_68f2bd3d611c7a2a832128d8430d9193 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P1-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-28 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P27-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D403-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D267-22 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D213-61 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-18 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D295-15 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P17-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P33-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P19-02 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D215-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-16 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P25-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P35-00 |
| filingDate | 2010-09-16^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3e9227ef1ae867d0d9cac0f0c414cd78 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a542ee6060b44d7370c099a6e03dec9c |
| publicationDate | 2011-10-19^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-078178-A1 |
| titleOfInvention | BENCENO-CARBOXAMIDE COMPOUNDS AS INHIBITORS OF THE TNF CONVER-TIDORA ENZYME |
| abstract | Benzene-carboxamide compounds and their use in pharmaceutical compositions intended for use in human or veterinary medicine or for use in cosmetic compositions. Claim 1: Compound of the general formula 1 presented below: (1) wherein: R1 and R2 are identical or different and represent alkyl radicals or form a ring with the nitrogen atom to which they are attached, said ring is represented by the following formula: (2), X, myn have the meanings given below; R3 is a hydrogen atom or a lower alkyl radical comprising from 1 to 4 carbon atoms; R4 is an alkyl radical comprising from 1 to 10 carbon atoms, an alkyl radical substituted with one or more radicals selected from a halogen atom, an alkoxy radical and a hydroxyl radical, an alkenyl radical comprising from 2 to 10 atoms of carbon, an alkenyl radical substituted with one or more radicals selected from a halogen atom, an alkoxy radical and a hydroxyl radical, an alkynyl radical comprising from 2 to 10 carbon atoms, an alkynyl radical substituted with one or more radicals selected from a halogen atom, an alkoxy radical and a hydroxyl radical, an aryl radical, an aryl radical substituted with one or more groups of atoms selected from an alkyl, an alkoxy, an aryl, a halogen, a hydroxyl, a cyano, a trifluoromethyl and a nitro, an aralkyl radical, a substituted aralkyl radical, a heterocyclic radical, a heterocyclic radical substituted with one or more groups of atoms selected from an alkyl, an alkoxy, a halogen, a hydroxyl, a cyano, a trifluoromethyl and a nitro, a cycloalkyl radical, a cycloalkyl radical substituted with one or more radicals selected from a halogen atom, an alkoxy radical and a hydroxyl radical, a heteroaryl radical, a heteroaryl radical substituted with one or more groups of atoms selected, for example, from an alkyl, an alkoxy, an aryl, a substituted aryl, a halogen, a hydroxyl, a cyano, a trifluoromethyl and a nitro, a radical heteroaralkyl, a heteroaralkyl radical substituted with one or more groups of atoms selected from an alkyl, an alkoxy, a halogen, a hydroxyl, a cyano, a trifluoromethyl and a nitro; X represents an oxygen atom, a radical -CH2-, a radical -CH- (CH2) p-NR5R6, a sulfur atom, a radical SO or a radical SO2, R5, R6 and p have the meanings given below; R5 and R6, which may be identical or different, represent a hydrogen atom, an alkyl radical comprising from 1 to 10 carbon atoms, an alkyl radical substituted with one or more radicals selected from a halogen atom, an alkoxy radical and a hydroxyl radical, an aryl radical or an aryl radical substituted with one or more groups of atoms selected from an alkyl, an alkoxy, an aryl, a halogen, a hydroxyl, a cyano, a trifluoromethyl or a nitro; m can take the values of 0 or 1; n can take the values of 0, 1, 2 or 3; p can take the values of 0, 1 or 2; and also the addition salts of the compounds of general formula 1 with a pharmaceutically acceptable acid, the addition salts of the compounds of general formula 1 with a pharmaceutically acceptable base and the enantiomers of the compounds of the general formula 1. |
| priorityDate | 2009-09-17^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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