http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-084606-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_966a6c1f382ec9bcb5e3839dfd73e5b8 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4245 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P13-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D305-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4427 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D405-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K38-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K7-18 |
| filingDate | 2011-12-27^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5da5dea38a5b59e4f438b848a75314c5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2e6de93399b16fca8512d7b71b40edec http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f441ff876193085f200ced0714c8c109 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4f43a0c305fce757538780a94e5c39be http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_891b715ee6b183c041653b3d248ad6fd http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_08aa9a0ba83c3b64e64d5fb66a7eaaad http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_5df9d7e996793a85d4a746fdaa693d97 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c265bef07dfd41f4539bfc416499585e |
| publicationDate | 2013-05-29^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-084606-A1 |
| titleOfInvention | BIARIL-AMIDA DERIVATIVES |
| abstract | Process for obtaining the disclosed compound Claim 1: Compounds of the formula (1) in which: R 1 is alkyl, cycloalkyl, cycloalkylalkyl, alkoxyalkyl, cycloalkoxyalkyl, haloalkyl, haloalkoxyalkyl, halocycloalkyl, halocycloalkylalkyl, halocycloalkoxaryl, aryl, substituted aryl, aryl, substituted aryl substituted heteroaryl, said aryl and heteroaryl are substituted with one to three substituents independently selected from alkyl, cycloalkyl, alkylcycloalkyl, cycloalkylalkyl, cycloalkylalkoxy, cycloalkylalkoxyalkyl, cycloalkoxy, cycloalkoxyalkyl, alkylcycloalkylalkyl, halocycloalkyl, halocycloalkylalkyl, halogen, haloalkyl, hydroxy, hydroxyalkyl , alkoxy, alkoxyalkyl, haloalkoxy, hydroxyalkoxy, alkoxyalkoxy, alkoxyalkoxyalkyl, hydroxyhaloalkyl, amino and substituted amino, said substituted amino is substituted by one or two substituents independently selected from alkyl, cycloalkyl, alq uylcycloalkyl, cycloalkylalkyl, alkylcycloalkylalkyl, hydroxyalkyl and alkoxyalkyl; R2 is hydrogen, alkyl or cycloalkyl; R3 is hydrogen, alkyl or cycloalkyl; R4 is hydrogen, alkyl or cycloalkyl; R5 is hydrogen, alkyl or cycloalkyl; or R4 and R5 together with the carbon atom to which they are attached form a cycloalkyl; R6 is hydrogen, alkyl, alkoxy, cycloalkyl, halogen or cyano; R7 is hydrogen, alkyl, alkoxy, cycloalkyl, halogen or cyano; R8 is alkyl, cycloalkyl, cycloalkylalkyl, alkoxy, alkoxyalkyl, cycloalkoxy, cycloalkoxyalkyl, haloalkyl, haloalkoxy, haloalkoxyalkyl, halocycloalkyl, halocycloalkylalkyl, halocycloalkoxy, halocicloalcoxialquilo, alkoxycarbonyl, cycloalkoxycarbonyl, haloalkoxycarbonyl, halocicloalcoxicarbonilo, aryl, substituted aryl, heteroaryl or substituted heteroaryl, said aryl and heteroaryl are substituted with one to three substituents independently selected from alkyl, cycloalkyl, alkylcycloalkyl, cycloalkylalkyl, cycloalkylalkoxy, cycloalkylalkoxyalkyl, cycloalkoxy, cycloalkoxyalkyl, alkylcycloalkylalkyl, halocycloalkyl, halocycloalkylalkyl, halogen, haloalkyl, alkoxy, alkoxyalkyl, haloalkoxy, alkoxyalkoxy, alkoxyalkoxyalkyl, amino and substituted amino, said substituted amino is substituted by one or two substituents independently selected from alkyl, cycloalkyl, alkylcycloalkyl, cycloalkylalkyl or, alkylcycloalkylalkyl, hydroxyalkyl and alkoxyalkyl; R9 is hydrogen, alkyl, alkoxy, cycloalkyl, halogen or cyano; R10 is hydrogen, alkyl, alkoxy, cycloalkyl, halogen or cyano; R11 is hydrogen, alkyl, alkoxy, cycloalkyl, halogen or cyano; R12 is hydrogen, alkyl, alkoxy, cycloalkyl, halogen or cyano; R13 is hydrogen, alkyl, alkoxy, cycloalkyl, halogen or cyano; A is CR13 or N; or its pharmaceutically acceptable salts. Claim 20: The use of a compound according to any one of claims 1 to 14 for the manufacture of a medicament for the treatment or prophylaxis of glomerulonephritis, the purple nephropathy of Henoch-Schönlein, the growing nephropathy associated with ANCA, the Lupus nephritis and IgA nephritis. Claim 22: A method of treatment or prophylaxis of glomerulonephritis, Henoch-Schönlein purple nephropathy, the increasing nephropathy associated with ANCA, lupus nephritis and IgA nephritis, said method consists of administering an effective amount of a compound according to any one of claims 1 to 14. |
| priorityDate | 2010-12-27^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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