http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-109701-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_f52c68e4149a6c462b850d4e7cc2b2f9 http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c7ad58d3c0b071069a8ee0cb8c8ba2e8 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D495-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-519 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P11-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-10 |
| filingDate | 2017-09-22^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_3650f06518b48a249b4f0f34a312b181 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7d0a7bc0b556d1341a7f0431b2b82e4a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_314fa7830433c28e0f93ab2fd4b3fafa http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a9e7076805aad803e007d8886711920 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_fc5dd97809807ba4ba826729b081e969 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b3c5b2cfb3d50e6f5f6dc199e9842421 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e7dbec552d022f16c95075941412b892 |
| publicationDate | 2019-01-16^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-109701-A1 |
| titleOfInvention | TIENOURACILOS N3-CYCLICALLY SUBSTITUTED AND USE OF THE SAME |
| abstract | The present application relates to thieno [2,3-d] pyrimidine-2,4-dione derivatives ("thienouracil"), to their use alone or in combinations to treat and / or prevent diseases and to use thereof to produce drugs to treat and / or prevent diseases, especially to treat and / or prevent pulmonary and cardiovascular disorders and cancer. Claim 1: A compound of the formula (1), wherein the ring A is an azaheterocycle selected from the group of formulas (2), in which * marks the bond to the adjacent group C (R¹A) (R¹B), R⁵A and R⁵B are the same or different and are independently hydrogen or C₁₋₄-alkyl, R⁶ is hydrogen or C₁₋₄-alkyl, and X is O, S or N (R⁷), where R⁷ is cyano, methoxycarbonyl or ethoxycarbonyl, R¹A and R¹B they are independently hydrogen or deuterium, R² is methyl or ethyl, R³ is cyclopropyl, cyclobutyl, cyclopentyl, spiro [3.3] hept-2-yl, 3-oxetanyl or 3-tetrahydrofuranyl, wherein cyclopropyl, cyclobutyl, cyclopentyl and spiro [3.3] hept-2-yl may even be disubstituted, identically or differently, by a radical selected from fluorine, methyl, ethyl, trifluoromethyl and methoxy, and wherein 3-oxetanyl and 3-tetrahydrofuranyl may be disubstituted, identically or different, by a radical selected from fluorine and methyl, and R⁴ is methyl, ethyl, 2-fluorethyl, 2,2-difluoroethyl, 2,2,2-trifluoroethyl, n-propyl, 3-cyanopropyl, 3-fluoropropyl, 3,3-difluoropropyl, 3,3,3-trifluoropropyl, n-butyl, 4-fluorobutyl, 4,4,4-trifluorobutyl, 3,3,4,4-tetrafluorobutyl, n-pentyl, iso-pentyl or n-hexyl, or R⁴ is a group of the formula -CH₂-R⁸, where R⁸ is cyano, cyclopropyl, cyclobutyl, cyclopentyl, 2-oxetanyl, 3-oxetanyl, 2-tetrahydrofuranyl or 3-tetrahydrofuranyl, wherein cyclopropyl, cyclobutyl and cyclopentyl can be disubstituted with fluorine, or R⁴ is a group of the formula -CH₂-CH₂ -OR⁹ or -CH₂-CH₂-SR¹⁰, where R⁹ is methyl, trifluoromethyl, ethyl or iso-propyl and R¹⁰ is methyl or trifluoromethyl, and its solvates. |
| priorityDate | 2016-09-23^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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