http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-111220-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_173bc2c63b34988699010ba05e5b1376 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A01N43-72 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D471-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D417-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D413-14 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01P3-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-836 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 |
| filingDate | 2018-03-02^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1c9bfa2f700ffc3a38073ac9b178fdce http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_caa6d472af07d48850f89e47f7aa8e5a http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a3167b5f38f62663ebe78ec9b3ab679d http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_87c517d91e9e0215decd5c0995dd4dc8 |
| publicationDate | 2019-06-19^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-111220-A1 |
| titleOfInvention | MICROBICIDE OXADIAZOL DERIVATIVES |
| abstract | These compounds are useful as pesticides, especially as fungicides. Claim 1: A compound of formula (1), wherein A is selected from the compounds of formula (2), (3) or (4); R¹ and R² independently represent hydrogen, methyl, ethyl, fluoro, cyano, difluoromethyl or trifluoromethyl; and Z is selected from Z¹, Z², or Z³; where Z¹ represents a 4- to 6-membered non-aromatic heterocyclyl ring containing 1 ring nitrogen, where the heterocyclyl optionally comprises 1 or 2 additional ring members independently selected from N, O, S, C (O) and S (O) ₂ with the condition that the heterocyclyl ring cannot contain 2 contiguous atoms selected from O and S, or the heterocyclyl optionally comprises 1 additional ring member NR³, where the heterocyclyl is optionally substituted with 1 or 2 substituents, which may be identical or different, selected from R⁴, and where in addition the heterocyclyl is attached to the rest of the molecule through an annular nitrogen; R³ represents hydrogen, hydroxy, amino, formyl, C₁₋₃ alkyl, C₁₋₃ alkoxy, (C₁₋₃ alkyl) carbonyl, (C₁₋₃ alkoxy) carbonyl, N- (C₁₋₃ alkyl) aminocarbonyl, N, N- di (C₁₋₃ alkyl) aminocarbonyl, N- (C₁₋₃ alkoxy) aminocarbonyl, N- (C₁₋₃ alkyl) -N- (C₁₋₃ alkoxy) aminocarbonyl, C₁₋₂ alkylsulfonyl, N-C₁₋₂ alkylaminosulfonyl, N, N-dialkylaminosulfonyl C₁₋₂, (C₁₋₂ alkyl) dicarbonyl, (C₁₋₂ alkoxy) dicarbonyl, N- (C₁₋₂ alkyl) aminodicarbonyl or N, N-di (C₁₋₂ alkyl) aminodicarbonyl; R⁴ represents cyano, halogen, hydroxy, amino, methyl, ethyl, difluoromethyl, trifluoromethyl, methoxy, N-methylamino or N, N-dimethylamino; Z² represents a 5 or 6 membered heteroaryl ring containing 1 annular nitrogen, where the heteroaryl optionally comprises 1, 2 or 3 additional annular members independently selected from O, S or N, and where the heteroaryl is optionally substituted with: 1 or 2 substituents selected from R⁵, 1 substituent selected from R⁶, or 1 substituent selected from R⁵ and 1 substituent selected from R⁶, and where in addition the heteroaryl is attached to the rest of the molecule through an annular nitrogen; R⁵ represents hydroxyl, amino, cyano, halogen, formyl, nitro, C₁₋₄ alkyl, C₁₋₄ alkoxy, C₃₋₄ alkenyl, C₃₋₄ alkynyl, C₃₋₄ alkynyloxy, C₁₋₂ cyanoalkyl, haloalkyl C₁₋₂, C₁₋₂ hydroxyalkyl, (C₁₋₂ alkoxy) (C₁₋₂ alkyl), (C₁₋₂ alkoxy) (C₁₋₂ alkyl), N, N-dimethylamino, (C₁ alkoxy ₋₃) carbonyl (C₁₋₂ alkyl), (C₁₋₃ alkyl) carbonyloxy (C₁₋₂ alkyl), N- (C₁₋₃ alkyl) aminocarbonyl (C₁₋₂ alkyl), N, N-di (C₁₋ alkyl ₃) aminocarbonyl (C₁₋₂ alkyl), C₁₋₂ alkyl sulfonyl, (C₁₋₃ alkyl) carbonyl, (C₁₋₃ alkyl) dicarbonyl, (C₁₋₃ alkoxy) dicarbonyl, N- (C₁₋₃ alkyl) aminodicarbonyl or N , N-di (C₁₋₃ alkyl) aminodicarbonyl; or R⁵ represents -C (O) N (Rᵃ) (Rᵇ), where: Rᵃ represents hydrogen, C₁₋₆ alkyl, C₃₋₄ alkenyl, C₃₋₄ alkynyl, C₁₋₃ haloalkyl, C₃₋₄ haloalkenyl, C₁₋ alkoxy ₄, (C₁₋₂ alkoxy) (C₁₋₃ alkyl), C₂₋₃ haloalkoxy, C₃₋₄ alkynyloxy, C₃₋₄ alkynyloxy, N-C₁₋₃-alkylamino or N, N-Cquila-dialkylamino; or Rᵃ represents C₃₋₅ cycloalkyl, (C₃₋₅ cycloalkyl) (C₁₋₂ alkyl), phenyl, phenyl (C₁₋₂ alkyl), heterocyclyl, wherein the heterocyclyl moiety is a 4 to 6 membered non-aromatic ring which comprises 1 or 2 heteroatoms independently selected from N, O or S, with the proviso that the heterocyclyl cannot contain 2 contiguous atoms selected from O and S, heteroaryl or heteroaryl (C₁₋₂ alkyl), where the heteroaryl moiety is an aromatic ring 5 or 6 members which comprises 1, 2, 3 or 4 heteroatoms individually selected from N, O and S; where the cycloalkyl, phenyl, heterocyclyl or heteroaryl is optionally substituted with 1 or 2 substituents, which may be identical or different, selected from hydroxyl, amino, formyl, acyl, cyano, halogen, methyl, trifluoromethyl, methoxy or N, N- dimethylamino, and where when Rᵃ represents cycloalkyl or heterocyclyl, these cycles optionally contain 1 group selected from C (O) or S (O) ₂; and Rᵇ represents hydrogen, methyl, ethyl, propyl, prop-2-enyl, prop-2-inyl, cyclopropyl or cyclopropylmethyl; or Rᵃ and Rᵇ, together with the nitrogen atom they share, form an azetidinyl, pyrrolidinyl, isooxazolidinyl, morpholino, piperazin-4-yl or piperidinyl ring optionally substituted with 1 or 2 groups selected from halogen, methyl, ethyl or methoxy; or R⁵ represents -C (O) O-Rᶜ, where: Rᶜ represents hydrogen, C₁₋₆ alkyl, C₃₋₅ alkenyl, C₃₋₅ alkynyl, C₁₋₃ haloalkyl, C₃₋₄ haloalkenyl, N, N-di (alkyl C₁₋₃) amino (C₁₋₃ alkyl), C₃₋₆ cycloalkyl, (C₃₋₄ cycloalkyl) (phenyl, heterocyclyl, where the heterocyclyl moiety is a 4 to 6 membered non-aromatic ring which it comprises 1 or 2 heteroatoms independently selected from O, S and N, with the proviso that the heterocyclyl cannot contain 2 contiguous atoms selected from O and S, heteroaryl, where the heteroaryl moiety is a 5 or 6 membered aromatic ring which it comprises 1, 2 or 3 heteroatoms individually selected from N, O and S; and where the cycloalkyl, phenyl, heterocyclyl or heteroaryl is optionally substituted with 1 or 2 substituents, which may be identical or different, selected from hydroxyl, amino, formyl, methylcarbonyl, cyano, halogen, methyl, trifluoromethyl, methoxy or N, N -dimethylamino, and where when Rᶜ represents cycloalkyl or heterocyclyl, these cycles optionally contain 1 group selected from C (O) or S (O) ₂; or R⁵ represents -N (Rᵈ) (Rᵉ) or - (C₁₋₂ alkyl) -N (Rᵈ) (Rᵉ), where Rᵈ represents C₁₋₃ alkyl, C₃₋₄ alkenyl, C₃₋₄ alkynyl, methylcarbonyl, methoxycarbonyl, N-methylaminocarbonyl, N, N-dimethylaminocarbonyl, N-methoxyaminocarbonyl, N-methyl-N-methoxyaminocarbonyl, methylsulfonyl, N-methylaminosulfonyl, N, N-dimethylaminosulfonyl, methyldicarbonyl, N-methylaminodicarbonyl or N, N-dimethylaminod; and Rᵉ represents hydrogen, methyl, ethyl or propyl; or Rᵈ and Rᵉ, together with the nitrogen atom they share, form an azetidinyl, pyrrolidinyl, isooxazolidinyl, morpholino, piperazin-4-yl or piperidinyl ring optionally substituted with 1 or 2 groups selected from halogen, methyl, ethyl or methoxy; or R⁵, represents -CH = N (Rᶠ), where Rᶠ represents C₁₋₄ alkyl, C₁₋₄ alkoxy, C₂₋₄ alkenoxy or C₂₋₄ alkyloxy; R⁶ represents C₃₋₆ cycloalkyl, phenyl, heteroaryl, where the heteroaryl moiety is a 5 or 6 membered aromatic ring which comprises 1, 2, 3 or 4 heteroatoms individually selected from N, O and S, heterocyclyl, where the heterocyclyl moiety it is a non-aromatic ring of 4 to 6 members which comprises 1 or 2 heteroatoms individually selected from N, O and S, and where the cycloalkyl, phenyl, heteroaryl and heterocyclyl is optionally substituted with 1 or 2 substituents, which may be identical or different, selected from hydroxyl, amino, formyl, acyl, cyano, halogen, methyl, trifluoromethyl, methoxy, N, N-dimethylamino, and where when R⁶ represents cycloalkyl or heterocyclyl, these cycles optionally contain 1 group selected from C (O) or S (O) ₂; and Z³ represents a heterobicyclyl which is a saturated 7, 9 saturated, partially saturated or aromatic condensed or annular spirocyclic saturated ring system containing 1 nitrogen, wherein the heterobicyclyl optionally comprises 1 or 2 additional annular members independently selected from N, O, S, C (O) and S (O) ₂ with the proviso that the heterobicyclyl cannot contain 2 contiguous atoms selected from O and S, where the heterobicyclyl is optionally substituted with 1 substituent selected from R⁷, and where the heterobicyclyl is also binds the rest of the molecule through an annular nitrogen; and R⁷ is cyano, fluoro, chloro, amino, hydroxy, methyl, difluoromethyl, trifluoromethyl, methoxy, N, N-dimethylamino, formyl, methylcarbonyl, methoxycarbonyl, N-methylaminocarbonyl or N, N-dimethylaminocarbonyl; or a salt or N-oxide thereof. |
| priorityDate | 2017-03-03^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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