http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-113003-A1

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classificationIPCInventive http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A01N43-78
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D417-14
filingDate 2018-09-07^^<http://www.w3.org/2001/XMLSchema#date>
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publicationDate 2020-01-15^^<http://www.w3.org/2001/XMLSchema#date>
publicationNumber AR-113003-A1
titleOfInvention HETEROCYCLIC FUNGICIDE CONCEPTS
abstract Claim 1: A compound of formula (1), wherein, E is a fragment selected from the group consisting of E-1, E-2, E-3, E-4 and E-5 from the group of formulas ( 4), wherein, T¹, T², T³ and T⁴ are independently selected from a 5- or 6-membered aryl ring, or a 5- or 6-membered saturated or partially saturated cyclic ring, or a 5- or 6-membered heteroaryl ring members, or a 5 or 6 or 7 membered saturated or partially saturated heterocyclic ring, wherein each ring member of the heteroaryl ring is selected from C, N, O, and S, and wherein each member ring of the heterocyclic ring is selected from C, N, O, S (O) ₐ, C (= O), C (= S), S (= NR²) and S (O) = NR², and T¹, T², T³ and T⁴ are optionally substituted by one or more R¹ in C atoms and by one or more R² in heteroatoms; or T², T³ and T⁴ are independently selected from C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₁₋₆ haloalkyl, C₂₋₆ haloalkenyl, C₂₋₆ haloalkynyl, C₃₋₈ cycloalkyl, C₃₋₈ halocycloalkyl, C₁₋₆Calkyl Calkyl, C₁₋₆Ccycloalkyl, C₃₋₈Ccycloalkyl, C₁₋₆C halo halocycloalkyl, C₁₋₆alkyl Calkyl, C₁₋₆C cycloalkoxyCalkyl, C₁ alkylthio C₁₋₆alkyl, C₁₋₆alkyl Calkylsulfinyl, C₁₋₆alkylsulfonyl C₁₋₆alkyl, C₁₋₆alkylamino C₁₋₆alkyl, C₁₋₆ dialkylamino C₁₋₆alkyl, C₁₋₆ haloalkylamino C₁₋₆alkyl, Calkyl cycloalkylamino C₁₋₆, C₁₋₆ alkylcarbonyl, C₁₋₆ haloalkylcarbonyl, C₃₋₈ cycloalkylcarbonyl, C₁₋₆ alkoxycarbonyl, C₃₋₈ cycloalkoxycarbonyl, C₁₋₆ alkylaminocarbonyl, C₁₋₆ dialkylaminocarbonyl, C₃₋₈ cycloalkylaminocarbonyl, C₁₋ haloalkoxy C₁₋₆alkyl ₆, C₁₋₆ hydroxyalkyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₃₋₈ cycloalkoxy, C₃₋₈ halocycloalkoxy, C₁₋₆ cycloalkyl C₁₋₆ alkoxy, C₂₋₆ alkenyloxy, haloalk C₂₋₆ enyloxy, C₂₋₆ alkynyloxy, C₂₋₆ haloalkynyloxy, C₁₋₆ alkoxy C₁₋₆ alkoxy, C₁₋₆ alkylcarbonyloxy, C₁₋₆ haloalkylcarbonyloxy, C₃₋₈ cycloalkylcarbonyloxy, C₁₋₆ alkylcarbonyl C₁₋₆alkoxy, C₁₋₆ alkylthio , C₁₋₆ haloalkylthio, C₃₋₈ cycloalkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ haloalkylsulfinyl, C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylsulfonyl, C₃₋₈ cycloalkylsulfonyl, C₁₋₆ trialkylsilyl, C₁₋₆ alkylsulfonylamino and C₁₋₆ haloalkylsulfonylamino ; L¹, L², L³, L⁴, and L⁵ are a direct bond independently, O, S (= O) ₐ, C (= O), C (= S), C (R²²) ₂, C (R²²) ₂-C (R²²) ₂- or NR²³; A is a direct bond or C (R⁴) ₂ or C (R⁴) ₂-C (R⁴) ₂, C (= O) or NR⁵; W is O or S; W¹ is OR¹⁸, SR¹⁹, N (R²⁰) ₂ or R²¹; a and m are independently 0, 1 or 2; Z is C or N; R³ is selected from hydrogen, halogen, cyano, hydroxy, amino, aldehyde, carboxylic acid, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₁₋₆ haloalkyl, C₂₋₆ haloalkenyl, C₂₋₆ haloalkynyl, cycloalkyl C₃₋₆, C₃₋₆ halocycloalkyl, C₃₋₆ C₁₋₆ alkyl, C₁₋₆ cycloalkyl, C₁₋₆ Calkyl, C halocycloalkyl, Cque cycloalkenyl, C₃₋₆ halocycloalkenyl, C₁₋₆ alkoxy C₁₋₆alkyl , C₁₋₆thio-C₁₋₆ alkyl, C₁₋₆sulfinylalkyl, C₁₋₆ alkyl, C₁₋₆sulfonylalkyl, C₁₋₆ alkylamino C₁₋₆alkyl, dialkylamino C₁₋₆alkyl, haloalkylamino C₁₋₆alkyl, alkylcarbonyl C₁₋₆, C₁₋₆ haloalkylcarbonyl, C₃₋₆ cycloalkylcarbonyl, C₁₋₆ alkoxycarbonyl, C₃₋₆ cycloalkoxycarbonyl, C₁₋₆ cycloalkyl C₃₋₆ alkoxycarbonyl, C₁₋₆ alkylaminocarbonyl, C₁₋₆ dialkylaminocarbonyl, C₁₋₆ alkoxy, C₁₋ haloalkoxy ₆, C₃₋₆ cycloalkoxy, C₃₋₆ halocycloalkoxy, C₂₋₆ alkenyloxy, C₁₋₆ haloalkenyloxy, C₂₋₆ alkynyloxy, C₂₋₆ haloalkynyloxy, C₁₋₆ alkoxy C₁₋₆alkoxy, alkyl lC lcarbonyloxy, C₁₋₆ haloalkylcarbonyloxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, C₃₋₆ cycloalkylthio, C₁₋₆ alkylamino, C₁₋₆ dialkylamino, C₁₋₆ haloalkylamino, C₁₋₆ halodialkylamino, C₃₋₆ cycloalkylamino, C₁₋₆ alkylcarbonyl amino, C₁₋₆ haloalkylcarbonyl amino, C₁₋₆ alkylsulfonylamino and C₁₋₆ haloalkylsulfonylamino; or two R³ are taken together as C₁₋₆ alkyl, C₁₋₄ alkylene or C₂₋₄ alkenylene to form a bicyclic bridge or fused bicyclic ring system; or two R³ attached to the adjacent ring carbon atoms are taken together as -CH = CH-CH = CH- optionally substituted with a substituent selected from C₁₋₄ alkyl, C₁₋₄ haloalkyl, C₁₋₄ alkoxy, C₁₋ haloalkoxy *, Halogen, hydroxy, amino, cyano, and nitro; the presentation “⁻ ⁻ ⁻ ⁻ ⁻” in the D ring is a single bond when Z is N and the presentation “⁻ ⁻ ⁻ ⁻ ⁻” is a single or double bond when Z is C; "N" is an integer ranging from 0 to 9 with the proviso that when Z is N, "n" is an integer ranging from 0 to 8; and when the presentation “⁻ ⁻ ⁻ ⁻ ⁻” in ring D is a double bond then “n” is an integer ranging from 0 to 7; G is a 5- or 6-membered heteroaryl ring or an optionally substituted 5- or 6-membered saturated or partially saturated heterocyclic ring, each member ring of the heteroaryl ring is selected from C, N, O, and S, wherein each member ring the heterocyclic ring is selected from C, N, O, S (O) ₐ, C (= O), C (= S), S (= NR²) and S (O) = NR²; wherein, the optional substituent on G is R³ᵃ on carbon ring members and R¹¹ᵃ on heteroatom ring members; R³ᵃ is hydrogen or R³ᵇ; R³ᵇ is phenyl, C₁₋₃ alkyl, C₁₋₃ haloalkyl, halogen, or a 5- or 6-membered heteroaryl ring optionally substituted with one or more substituents independently selected from R⁴ᵃ on the carbon ring members and R⁴ᵇ on the heteroatom ring members ; R⁴ᵃ is independently selected from C₁₋₆ alkyl, C₁₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, C₁₋₆ cycloalkyl, C₃₋₆ cycloalkyl, C₃₋₆ haloalkyl, C cycloalkyl, haloalkyl C₁₋₆, C₂₋₆ haloalkenyl, C₂₋₆ haloalkynyl, C₃₋₆ halocycloalkyl, halogen, hydroxy, amino, cyano, nitro, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ alkylsulfinyl, alkylsulfonyl C₁₋₆, C₁₋₆ haloalkylthio, C₁₋₆ haloalkylsulfinyl, C₁₋₆ haloalkylsulfonyl, C₁₋₆ alkylamino, C₁₋₆ dialkylamino, C₃₋₆ cycloalkylamino, C₁₋₆ alkoxy C₁₋₆alkyl, C₁₋₆ hydroxyalkyl, C₁₋ alkylcarbonyl ₆, C alco alkoxycarbonyl, C₁₋₆ alkylcarbonyloxy, C₁₋₆ alkylcarbonylthio, C₁₋₆ alkylaminocarbonyl, C₁₋₆ dialkylaminocarbonyl, and C₁₋₆ trialkylsilyl; R⁴ᵇ is independently selected from C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, C₁₋₆ haloalkyl, C₂₋₆ haloalkenyl, C₂₋₆ haloalkynyl, C₃₋₆ halocycloalkyl, and C₁ alkoxy C₁₋₆alkyl ₋₆; R¹¹ᵃ is hydrogen or R¹¹ᵇ; R¹¹ᵇ is independently C₁₋₃ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, C₁₋₆ haloalkyl, C₂₋₆ haloalkenyl, C₂₋₆ haloalkynyl, C₃₋₆ halocycloalkyl, and C₁₋₆ alkoxy C₁₋₆alkyl ; J is selected from fragments of formula (2) and (3) in which, the right side of the fragment of formula (2) or (3) is attached to Q and the left side of the fragment of formula (2) or (3) is attached to G; L⁶ and L⁷ are a direct bond independently, O, C (= O), C (= S), C (R¹²) ₂, C (R¹²) ₂-C (R¹²) ₂, NR¹³ or NR¹³C (= O); or L⁶ and L⁷ together with the atoms to which they are attached may form a 4- to 7-membered carbocyclic or heterocyclic ring or ring system; or R¹¹ together with L⁶ or L⁷ or G or Q or R¹² or R¹³ or R¹⁴ or R¹⁵ can form a 4- to 7-membered carbocyclic or heterocyclic ring or a ring system; Q is independently phenyl, benzyl, naphthalenyl, a 5 or 6 membered aryl ring, an 8 to 11 membered multi-cyclic aryl ring system, an 8 to 11 membered aryl fused ring system, to a heteroaryl ring of 5 or 6 membered, an 8 to 11 membered heteroaryl multi-cyclic ring system or an 8 to 11 membered heteroaryl fused ring system, each member ring of the heteroaryl ring or of the ring system is selected from C, N, O and S, and each ring or ring system is optionally substituted by R¹⁴ on carbon atoms and R¹⁵ on heteroatoms; or Q is independently a 3- to 7-membered non-aromatic carbocyclic ring, a 5-, 6-, or 7-membered non-aromatic heterocyclic ring, or an 8 to 15-membered non-aromatic multi-cyclic ring system, or a fused ring system 8 to 15 membered non-aromatic, each ring member of the non-aromatic ring or ring system is selected from C, N, O, S (O) ₐ, C (= O), C (= S), S (= NR²) and S (= O) = NR² and SiR¹⁶R¹⁷, and each ring or ring system is optionally substituted by R¹⁴ on carbon atoms and R¹⁵ on heteroatoms; R¹⁶ and R¹⁷ are independently selected from C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₃₋₆ cycloalkyl, C₃₋₆ halocycloalkyl, C₁₋₆ cycloalkyl, C₃₋₆ cycloalkyl, C₁ haloalkyl ₋₆C₃₋₆ cycloalkyl, C₁₋₆ haloalkyl, C₁₋₆ alkoxy, and C₁₋₆ haloalkoxy; R¹, R², R⁶, R⁷, R⁸, R⁹, R¹⁰, R¹⁴, R¹⁵, R¹⁸, R¹⁹, R²⁰, R²¹, R²⁴ and R²⁷ are independently selected from hydrogen, halogen, hydroxy; cyano, nitro, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₁₋₆ haloalkyl, C₂₋₆ haloalkenyl, C₂₋₆ haloalkynyl, C₃₋₈ cycloalkyl, C₃₋₈ halocycloalkyl, C₁₋₆ C₁₋₆cycloalkyl alkyl ₈, C₃₋₈-C ciclo-cycloalkyl, C₃₋₈-C-cycloalkyl, C₁₋₆-halocycloalkyl, C₁₋₆-Calkyl, C₁₋₆-alkoxy, C₁₋₆-C-cycloalkoxy, C₁₋₆-alkylthio-Calkyl, C₁₋₆ alkylsulfinyl Calkyl, C₁₋₆ alkylsulfonyl, C₁₋₆ alkylamino, C₁₋₆ dialkylamino, C₁₋₆ alkylamino C₁₋₆alkyl, C₁₋₆ dialkylamino C₁₋₆alkyl, C₁₋₆ haloalkylamino C₁₋₆alkyl, C₃₋₈ cycloalkylamino, C₁₋₆ cycloalkylamino C₃₋₈alkyl, C₁₋₆ alkylcarbonyl, C₁₋₆ haloalkylcarbonyl, C₃₋₈ cycloalkylcarbonyl, C₁₋₆ alkoxycarbonyl, C₃₋₈ cycloalkoxycarbonyl, C₁₋₆ alkylaminocarbonyl, C₁₋₆ dialkylaminocarbonyl, C₃ cycloalkylaminocarbonyl ₋₈, C₁₋₆ haloalkoxy, C₁₋₆ hydroxyalkyl, C₁₋₆ hydroxyalkenyl, C₁₋₆ hydroxyalkynyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ cycloalkoxy, halocycl C₃₋₈ oalkoxy, C₁₋₆ cycloalkyl C₁₋₆ alkoxy, C₂₋₆ alkenyloxy, C₂₋₆ haloalkenyloxy, C₂₋₆ alkynyloxy, C₂₋₆ haloalkynyloxy, C₁₋₆ alkoxy C₁₋₆, C₁₋₆ alkylcarbonyloxy, C₁₋₆ haloalkylcarbonyloxy , C₃₋₆ cycloalkylcarbonyloxy, C₁₋₆ alkylcarbonyl C₁₋₆alkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, C₃₋₈ cycloalkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ haloalkylsulfinyl, C₁₋₆ alkylsulfonyl, C₁₋₆ haloalkylsulfonyl, cycloalkylsulfonyl C₃₋₈, C₃₋₈ cycloalkylsulfinyl, C₁₋₆ trialkylsilyl, C₁₋₆ alkylsulfonylamino, C₁₋₆ haloalkylsulfonylamino, C₁₋₆ alkylcarbonylothio, C₁₋₆ alkylsulfonyloxy, C₁₋₆ alkylsulfinyloxy, arylsulfonyloxy, arylsulfinyloxy, arylsulfonyl, arylsulfinyl, cyano ₆, C₂₋₆ alkenylcarbonyloxy, C₁₋₆ alkoxy C₁₋₆alkylthio, C₁₋₆ alkylthio C₁₋₆alkoxy, C₂₋₆ haloalkenylcarbonyloxy, C₂₋₆ alkoxy C₂₋₆alkynyl, C₂₋₆ alkynylthio, C₃₋₈ halocycloalkylcarbonyloxy, C₂₋₆ alkenylamino , C₂₋₆ alkynylamino, C₁₋₆ haloalkylamino, C₁₋₆ cycloalkyl C₁₋₆ alkylamino, alkoxyamino C₁₋₆, C₁₋₆ haloalkoxyamino, C₁₋₆ alkylcarbonyl amino, C₁₋₆ haloalkylcarbonyl amino, C₁₋₆ alkoxycarbonylamino, C₂₋₆ alkenylthio, C₁₋₆ haloalkoxycarbonyl, C₁₋₆ alkoxy C₁₋₆ alkylcarbonyl, C₁₋₆ haloalkoxycarbonylamino, C₁₋ alkoxy C₁₋₆ alkylaminocarbonyl, C₁₋₆ alkylthiocarbonyl, C₁₋₆ cycloalkenyloxy C₃₋₈alkyl, C₁₋₆ alkoxy C₁₋₆alkoxycarbonyl, C₁₋₆ haloalkoxy C₁₋₆haloalkoxy, C₁₋₆ alkoxy C₁₋₆haloalkoxy, C₁₋₆ halocycloalkoxy C₃₋₈alkyl, C₁₋₆ dialkylaminocarbonylamino, C₂₋₆ alkoxy C₁₋₆alkenyl, C₁₋₆ alkylthiocarbonyloxy, C₁₋₆ haloalkoxy C₁₋₆alkoxy, C₁₋₆ haloalkylsulfonyloxy, C₁₋₆ C₁₋₆haloalkyl, C₁₋₆ dihaloalkylamino, C₁₋ dialkoxy C₁₋₆alkyl ₆, C₁₋₆ alkylaminocarbonylamino, C₁₋₆ haloalkoxy C₁₋₆haloalkyl, C₁₋₆ alkylaminocarbonyl, C₂₋₆ trialkylsilyl C₁₋₆alkynyloxy, C₁₋₆ trialkylsilyloxy, C₂₋₆ trialkylsilyl C₁₋₆alkynyl, C₁₋ cyanoalkoxy C₁₋₆alkyl ₆, C₁₋₆ dialkylthio C₁₋₆alkyl, C₁₋₆ alkoxysulfonyl, C₃₋₈ halocycloalkoxycarbonyl, C₁₋ alkylation C₃₋₈ cycloalkylcarbonyl, C₁₋₆ halocyclo C₃₋₈alkylcarbonyl, C al alkenyloxycarbonyl, C₂₋₆ alkynyloxycarbonyl, C₁₋₆ cyanoalkoxycarbonyl, C₁₋₆ alkylthio C₁₋₆alkoxycarbonyl, C₂₋₆ alkynylcarbonyloxy, C₂₋₆ haloalkynylcarbonyloxy, cyanocarbonyloxy C₂₋₆ ₋₆, C₃₋₈ cycloalkylsulfonyloxy, C₁₋₆ cycloalkylsulfonyloxy, C₃₋₈ halocycloalkylsulfonyloxy, C₂₋₆ alkenylsulfonyloxy, C₂₋₆ alkynylsulfonyloxy, C₁₋₆ cyanoalkylsulfonyloxy, C₂₋₆ haloalkenylsulfonyloxy, haloalkylsulfonyloxy C, haloalkylsulfonyloxy C , C₂₋₆ cyanoalkenyloxy, C₂₋₆ cyanoalkynyloxy, C₁₋₆ alkoxycarbonyloxy, C₂₋₆ alkenyloxycarbonyloxy, C₂₋₆ alkynyloxycarbonyloxy, C₁₋₆ alkoxyalkylcarbonyloxy, sulfilimines, sulfoximines, SF₅ or -L⁸Q; L⁸ is independently selected from a direct bond, O, S (= O) ₐ, C (= O), C (= S), C (R²²) ₂, C (R²²) ₂-C (R²²) ₂, or NR²³ ; R⁴, R¹², and R²² are independently selected from hydrogen, halogen, cyano, hydroxy, aldehyde, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₁₋₆ haloalkyl, C₂₋₆ haloalkenyl, C₂₋₆ haloalkynyl, C₁₋₆Calkyl, C₁₋₆Calkylthio, C₁₋₆Calkyl sulfinyl, C₁₋₆Calkyl sulfonyl, C₁₋₆alkylcarbonyl, C₁₋₆Haloalkylcarbonyl, C₁₋₆alkoxycarbonyl, C₁₋alkoxycarbonyl ₆C₁₋₆ alkyl, C₁₋₆ alkylaminocarbonyl, C₁₋₆ dialkylaminocarbonyl, C₁₋₆ alkoxy, C₁₋₆ haloalkoxy, C₁₋₆ alkylthio, C₁₋₆ haloalkylthio, C₁₋₆ alkylsulfinyl, C₁₋₆ haloalkylsulfinyl, C₁₋₆ alkylsulfonyl and C₁₋₆ haloalkylsulfonyl; R⁵, R¹³, and R²³ are independently selected from hydrogen, C₁₋₆ alkyl, C₂₋₆ alkenyl, C₂₋₆ alkynyl, C₁₋₆ haloalkyl, C₂₋₆ haloalkenyl, C₂₋₆ haloalkynyl, C₁₋₆ alkoxy C₁₋₆alkyl, C₁₋₆ alkylthio C₁₋₄alkyl, C₁₋₆ alkylsulfinyl, C₁₋₆ alkylsulfonyl C₁₋₆alkyl, C₁₋₆ alkylcarbonyl, C₁₋₆ haloalkylcarbonyl, C₁₋₆ alkoxycarbonyl, C₁₋₆ alkoxycarbonyl C₁₋₆alkyl, C₁₋ alkylaminocarbonyl *, C₁₋₆ dialkylaminocarbonyl, C₁₋₆ alkylsulfonyl, and C₁₋₆ haloalkylsulfonyl; and salts, metal complexes, N-oxides, isomers and polymorphs of the compounds of formula (1). Claim 6: A composition for the control or prevention of phytopathogenic microorganisms comprising; a) the compound of formula (1) according to claim 1, and b) one or more inert carriers. Claim 15: A method for controlling or preventing the infestation of useful plants by phytopathogenic microorganisms in agricultural or horticultural crops in which the compound of formula (1) according to claim 1 is applied to the plants, their parts or the place of the same. Claim 17: A process for preparing a compound of formula (10), wherein the process comprises the following steps: a) reacting a compound of formula (6) with a compound of formula (5) to obtain a compound of formula (4), where R²⁸ is -C (= O) OH, -C (= O) Cl, -C (= O) N₃, -CH₂OH or -CH₂X, where X is Cl, Br or I; R¹¹, G, L⁶ and Q are as defined in claim 1; b) converting the compound of the formula (7) into a compound of the formula (8) by deprotection reaction, wherein R¹¹, G, L⁶ and Q are as defined in claim 1; c) the compound of the formula (8) is reacted with a compound of the formula (9) to obtain the compound of the formula (10), wherein, R¹¹, G, L⁶, Q, W and T¹ are such as defined in claim 1.
priorityDate 2017-09-08^^<http://www.w3.org/2001/XMLSchema#date>
type http://data.epo.org/linked-data/def/patent/Publication

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