http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-119753-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c79a770a42baf0ec775483fcf0cbf6d3 |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P3-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P5-48 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-444 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4439 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D401-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-10 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P3-06 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D413-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-14 |
| filingDate | 2020-08-12^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_f18ee7b9b4c75ce81d78fe1b32a01bc3 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_d06a51347b1dfd36b9f3e71b5dcb6925 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_0a791eacbf7d1fa590f79488ae7f544c http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ce4b91c03798cc30dcada9e07e99387f http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_017b0c21fa2426c141918eac5ba22eb0 |
| publicationDate | 2022-01-12^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-119753-A1 |
| titleOfInvention | NON-PEPTIDE AGONISTS OF THE SOMATOSTATIN RECEPTOR TYPE 5 AND USES THEREOF |
| abstract | Claim 1: A compound of formula (1), or a pharmaceutically acceptable salt or solvate thereof, characterized in that: Ring A is carbocycle or heterocycle; X is N or C-Rᵃ; Y is N or C-Rᵇ; Z is N or C-Rᶜ; Rᵃ, Rᵇ, and Rᶜ are each independently hydrogen, halogen, -CN, -N(R⁹)₂, -ORᶠ, -CO₂R⁹, -C(=O)N(R⁹)₂, substituted or unsubstituted C₁₋₆ alkyl substituted or unsubstituted C₁₋₆ fluoroalkyl, substituted or unsubstituted C₁₋₆ fluoroalkoxy, substituted or unsubstituted C₁₋₆ heteroalkyl, substituted or unsubstituted monocyclic carbocycle, or substituted or unsubstituted monocyclic heterocycle; Rᶠ is -L¹-Rᵍ; L¹ is absent, is C₁₋₆ alkylene, C₁₋₆ fluoroalkylene, or C₁₋₆ heteroalkylene; Rᵍ is hydrogen, substituted or unsubstituted C₃₋₆ cycloalkyl, substituted or unsubstituted phenyl, -CO₂R⁹, or -C(=O)N(R⁹)₂, substituted or unsubstituted monocyclic heterocycle; R¹ and R² are independently hydrogen, substituted or unsubstituted C₁₋₆ alkyl, substituted or unsubstituted C₁₋₆ fluoroalkyl, substituted or unsubstituted C₁₋₆ heteroalkyl, substituted or unsubstituted C₃₋₆ cycloalkyl, or substituted or unsubstituted; R³ is hydrogen, -CN, -CO₂R⁹, -C(=O)N(R⁹)₂, substituted or unsubstituted C₁₋₆ alkyl, substituted or unsubstituted C₁₋₆ fluoroalkyl, substituted or unsubstituted C₁₋₆ alkoxy, fluoroalkoxy substituted or unsubstituted C₁₋₆, or substituted or unsubstituted C₁₋₆ heteroalkyl; R⁴ and R⁵ are each independently hydrogen, halogen, -OR⁹, -N(R⁹)₂, -CN, -CO₂R⁹, -C(=O)N(R⁹)₂, substituted or unsubstituted C₁₋₆ alkyl, C₁ fluoroalkyl substituted or unsubstituted ₋₆, substituted or unsubstituted C₁₋₆ alkoxy, substituted or unsubstituted C₁₋₆ fluoroalkoxy, or substituted or unsubstituted C₁₋₆ heteroalkyl; R⁶ is substituted or unsubstituted C₁₋₈ alkyl, substituted or unsubstituted C₁₋₈ fluoroalkyl, substituted or unsubstituted C₁₋₈ heteroalkyl, or -L²-R⁶ᵃ; L² is absent, is substituted or unsubstituted C₁₋₈ alkylene, or -CHR⁶ᵇ-; R⁶ᵃ is substituted or unsubstituted C₃₋₁₀ cycloalkyl, substituted or unsubstituted C₆₋₁₀ aryl, substituted or unsubstituted C₂₋₁₀ heterocycloalkyl, or substituted or unsubstituted C₁₋₉ heteroaryl; R⁶ᵇ is hydrogen, substituted or unsubstituted C₁₋₆ alkyl, C₁₋₆ fluoroalkyl, or C₃₋₆ cycloalkyl; R⁷ is hydrogen, substituted or unsubstituted C₁₋₆ alkyl, substituted or unsubstituted C₁₋₆ fluoroalkyl, substituted or unsubstituted C₁₋₆ heteroalkyl, substituted or unsubstituted C₃₋₁₀ cycloalkyl, substituted or unsubstituted C₆₋₁₀ aryl, heterocycloalkyl substituted or unsubstituted C₂₋₁₀, or substituted or unsubstituted C₁₋₉ heteroaryl; or R⁶ and R⁷ are taken together with the nitrogen to which they are bonded so as to form a substituted or unsubstituted N-containing heterocycle; each R⁸, R¹¹, and R¹² is independently hydrogen, halogen, substituted or unsubstituted C₁₋₆ alkyl, substituted or unsubstituted C₁₋₆ fluoroalkyl, substituted or unsubstituted C₁₋₆ heteroalkyl, substituted or unsubstituted monocyclic carbocycle, substituted monocyclic heterocycle or unsubstituted, -CN, -OR⁹, -C(=O)R¹⁰, -CO₂R⁹, -C(=O)N(R⁹)₂, -N(R⁹)₂, -NR⁹C(=O)R¹⁰, -NR⁹C (=O)OR¹⁰, -NR⁹C(=O)N(R⁹)₂, -C(R⁹)=N-OR⁹, -SR⁹, -S(=O)R⁹, -SO₂R⁹, or -SO₂N(R⁹)₂; or R¹¹ is taken together with an adjacent R⁸ and the atoms link the R¹¹ and the adjacent R⁸ to form a substituted or unsubstituted fused carbocycle, or a substituted or unsubstituted fused heterocycle; each R⁹ is independently hydrogen, substituted or unsubstituted C₁₋₆ alkyl, substituted or unsubstituted C₁₋₆ fluoroalkyl, substituted or unsubstituted C₁₋₆ heteroalkyl, substituted or unsubstituted C₃₋₇ cycloalkyl, substituted 3- to 8-membered monocyclic heterocycloalkyl or unsubstituted, substituted or unsubstituted phenyl, and substituted or unsubstituted monocyclic heteroaryl; or two R⁹ on the same N atom are taken together with the N atom to which they are bonded so as to form a substituted or unsubstituted N-containing heterocycle; each R¹⁰ is independently substituted or unsubstituted C₁₋₆ alkyl, substituted or unsubstituted C₁₋₆ fluoroalkyl, substituted or unsubstituted C₁₋₆ heteroalkyl, substituted or unsubstituted C₃₋₇ cycloalkyl, substituted or unsubstituted 3- to 8-membered monocyclic heterocycloalkyl substituted, substituted or unsubstituted phenyl, and substituted or unsubstituted monocyclic heteroaryl; and n is from 0 to 3. |
| priorityDate | 2019-08-14^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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