http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AR-121088-A1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_8281ac9f4fb11f15a5da018344453338 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4355 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P31-14 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D491-048 |
| filingDate | 2021-01-21^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_42fee77b8915abbbeb5f7699b7c38af5 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_6e8a3f3873f5921eb9f57df16e0757df http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ca7297b5b93f49d0d5f6fc267c9e22da http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_9451220e6d77d403c33a4455c78bcc27 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_351f14989fac122a70ba52944a44db40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a582311bf84146893c583b5a1790151b http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_1ebf4eb12fd559cc9534da7a5c40fe02 |
| publicationDate | 2022-04-13^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AR-121088-A1 |
| titleOfInvention | COMPOUNDS DERIVED FROM 2,3-DIHYDROFURO[2,3-c]PYRIDINE AS ANTIVIRAL AGENTS |
| abstract | Compounds derived from 2,3-furo[2,3-c]pyridine that possess antiviral properties, in particular against respiratory syncytial virus (RSV) and human metapneumovirus (HMPV); pharmaceutical composition comprising one of these compounds and the use thereof for the treatment of RSV and HMPV infections. Claim 1: A compound represented by formula (1), or a pharmaceutically acceptable salt thereof, wherein: A is an optionally substituted aryl or optionally substituted heteroaryl; B is O or S; R¹ and R² are each independently hydrogen or optionally substituted C₁₋₄ alkyl; alternatively, R¹ and R² are taken together with the carbon atom to which they are attached to form an optionally substituted 3-6 membered cyclic ring; R³ is selected from the group consisting of hydrogen, hydroxy, and optionally substituted C₁₋₆ alkoxy; R⁴ is selected from the group consisting of hydrogen, optionally substituted C₁₋₆ alkyl, optionally substituted C₁₋₆ alkenyl, optionally substituted C₁₋₆ alkynyl, optionally substituted C₃₋₆ cycloalkyl, and optionally substituted 3-6 membered heterocyclic ring; Z is selected from the group consisting of hydrogen, halogen, cyano, optionally substituted C₁₋₆ alkyl, optionally substituted C₃₋₆ cycloalkyl, and optionally substituted C₁₋₆ alkoxy; E is an optionally substituted aryl, optionally substituted heteroaryl, or optionally substituted heterocyclic ring; G is NR⁵R⁶; R⁵, R⁶ is each independently selected from: 1) hydrogen, 2) optionally substituted C₁₋₆ alkyl, 3) optionally substituted C₃₋₆ cycloalkyl, 4) optionally substituted 3-6 membered heterocyclic ring, 5) optionally substituted aryl, 6) optionally substituted heteroaryl, 7) -C(=O)R⁷, 8) -C(=O)OR⁷, 9) -C(=O)NHR⁷, 10) -C(=NH)R⁷, 11) -C (=NH)NHR⁷, 12) -C(=NH)NHCN, 13) -C(=NH)NHC(=O)R⁷, 14) -SO₂R⁷, and 15) -SO₂NHR⁷, alternatively, R⁵ and R⁶ are taken together with the nitrogen to which they are attached to form an optionally substituted 3-8 membered heterocyclic ring; where, R⁷ is selected from the group consisting of hydrogen, optionally substituted C₁₋₆ alkyl, optionally substituted C₃₋₆ cycloalkyl, optionally substituted 3-6 membered heterocyclic ring, optionally substituted aryl, and optionally substituted heteroaryl; and n is 1, 2 or 3. |
| priorityDate | 2020-01-24^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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