| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_c764b784bb5ffea37b768d0ad42f10d9 |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-158
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N2800-52
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q2600-106 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C12Q1-6886
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57415
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/G01N33-57492 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/G01N33-574 |
| filingDate |
2015-06-03^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_32b070ebd1735849a349385e3e749184
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_b6fa44da6b67988e66eef6ef9a59ae1e
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_a9b2f997ea33c771fc82f1029b84b386
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8f5c52eaae1c0ff3cf2146b68e3fed3d
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_06a7c8923e56e83b88c5e25bb61fd27c
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_28328112538a4d2eb198481d3e784e6a |
| publicationDate |
2016-10-27^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
AU-2015270575-A1 |
| titleOfInvention |
Significance of intratumoral HER2 heterogeneity in breast cancer and uses therefore |
| abstract |
Disclosed herein are methods for predicting the response to a HER2-directed therapy and for scoring a breast cancer tumor sample. In some embodiments, the methods include contacting the sample with an antibody that specifically binds HER2 protein and detecting presence and/or amount of HER2 protein and contacting the sample with a nucleic acid probe that specifically binds to HER2 genomic DNA and detecting presence and/or amount of HER2 genomic DNA (such as HER2 gene copy number). In some embodiments, the methods further include detection of a centromere nucleic acid (such as chromosome 17 centromere DNA) and contacting the sample with an antibody that specifically binds ER protein and detecting presence and/or amount of ER protein in the same sample. |
| priorityDate |
2014-06-06^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |