http://rdf.ncbi.nlm.nih.gov/pubchem/patent/AU-2016102170-A4
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_dd20b094ffaae58b31b1869dfad95d32 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-30 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07C253-18 |
| filingDate | 2016-12-22^^<http://www.w3.org/2001/XMLSchema#date> |
| grantDate | 2017-02-16^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_8d9d195afaf931dbed1c2590063dfee1 |
| publicationDate | 2017-02-16^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | AU-2016102170-A4 |
| titleOfInvention | Aminopterin sodium drug intermediates cyanoacetamide synthesis method |
| abstract | Aminopterin sodium drug intermediates cyanoacetamide synthesis method, comprising the following steps: equipped with a stirrer, a reaction vessel was added 500ml of N- (3-hydroxyphenyl) acetamide solution, controlling the stirring speed at 100-160 rpm, 3.6 mol ethyl cyanoacetate was added slowly in batches, increased solution temperature to 40--45 C , maintaining the stirring speed for 90-120min, the temperature of the solution is reduced to 5-8 C, the solid was precipitated, suction filtered, the solid was washed with trifluoroacetic acid solution in step (i) 5-7 times, and dried in a nitrogen atmosphere, got pale yellow solid, which was recrystallized from 500ml cyclohexane solution, ultimately got a white crystalline cyanoacetamide. |
| priorityDate | 2015-12-22^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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