| Predicate |
Object |
| assignee |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_59e1d955a7b1560dc68cf7fd800e8fac |
| classificationCPCAdditional |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-71
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-72
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-94
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-524
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61K2039-505
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K2317-52 |
| classificationCPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07K16-2866
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-00
http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 |
| classificationIPCInventive |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07K16-46
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N5-10
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K39-395
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N15-09
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-19
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-21
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12N1-15
http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C12P21-08 |
| filingDate |
2016-12-21^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor |
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_554692e962146635228e8a34efb0c284
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_61ea36198d5ca1d3c9813af3f11adbfd
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_7e65f50862c48d4aaec00394220ac78a
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_ede7adcadd6021cabd2ce1b6249ded3b
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_2b012f8252b63b4dd712c030781d8054
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_af226973a2cded1df8049b2cdb9fa5d4
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_841dc88d2c12c12e08284c8d67cbc5ad
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_e1768117da2014373abf4ae9759dfacc
http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_76610e1e1fe88d4ce4b3854f46731edd |
| publicationDate |
2017-01-19^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber |
AU-2016277645-A1 |
| titleOfInvention |
Method for altering plasma retention and immunogenecity of antigen-binding molecule |
| abstract |
The present invention demonstrated that the modification of the Fc region of an antigen-binding molecule into an Fc region that does not form in a neutral pH range a 5 heterotetramer complex containing two molecules of FcRn and an active Fcy receptor improved the pharmacokinetics of the antigen-binding molecule and reduced the immune response to the antigen-binding molecule. The present invention also revealed methods for producing antigen-binding molecules having the properties described above, and successfully demonstrated that pharmaceutical compositions containing as an active ingredient such an antigen-binding 0 molecule or an antigen-binding molecule produced by a production method of the present invention have excellent features over conventional antigen-binding molecules in that when administered, they exhibit improved pharmacokinetics and reduced in vivo immune response. |
| priorityDate |
2011-03-30^^<http://www.w3.org/2001/XMLSchema#date> |
| type |
http://data.epo.org/linked-data/def/patent/Publication |