| abstract |
USE OF AVERMECTIN DERIVATIVE FOR INCREASING BIOAVAILABILITY nAND EFFICACY OF MACROCYLIC LACTONES nAbstract nThe present invention relates to the use of avermectin derivative as a drug for the ntreatment of parasitic infections. The avermectin derivative is represented by the formula (I) nwherein: (i) R1 is chosen from the group constituted of -CH(CH 3)2, -CH(CH3)CH2CH3, or ncyclohexyle, (ii) X represents -CH2-CH2-, or -CH=CH-, (iii) R2 is chosen from the group nconstituted of or -OH group, (iv) R 3 is OH or NOH, (v) represents a single bond when R3 is nOH, or a double bond when R3 is NOH, as an inhibitor of a membrane-bound protein which ntransports exogenous compounds out of target cells. nH:\mdt\Interwoven\NRPortbl\DCC\MDT\15555534_1.docx - 21/8/17 |