| abstract |
The invention relates to compounds of the formula: wherein Ar represents an optionally substituted aryl or a C 5-7 cycloalkyldiyl group or an optionally substituted aromatic heterocyclic group containing one ring or fused rings; R represents C 1-6 alkyl, C 3-7 cycloalkyl, C 3-7 cycloalkylalkyl, optionally substituted phenyl or phenyl C 1-6 alkyl, optionally substituted heteroaryl ring containing up to four heteroatoms selected from O and N, hydroxy Cl C1-6 alkyl, amino C1-6 alkyl, C1-6 alkylaminoalkyl, diC1-6 alkylaminoalkyl, C1-6 acylaminoalkyl, C1-6 alkoxyalkyl, C1-6 alkylcarbonyl, carboxy, C1-6 alkoxycarbonyl, C1-6 alkoxycarbonyl- C1-6 alkylaminocarbonyl, di C1-6 alkylaminocarbonyl, halo C1-6 alkyl, or R is a group - (CH2) p - wherein p is 2 or 3 and a ring forms a ring with a carbon atom of Ar; R1 represents hydrogen or optionally up to four substituents selected from C1-6alkyl, C1-6alkenyl, aryl, C1-6alkoxy, hydroxy, halogen, nitro, cyano, carboxy, carboxamido, sulfonamido, C1-6alkoxycarbonyl, acyloxy, phthalimido, amino, or mono- and di C 1-6 alkylamino; R 2 represents hydrogen, C 1-6 alkyl, hydroxy, halogen, cyano, amino, mono- or di C 1-6 alkylamino, alkylsulfonylamino, mono- or di C 1-6 alkanoylamino wherein each alkyl group is optionally substituted by amino groups with mono - or a dialkylamino group, or R2 is a residue -X- (CH2) nY, in which Xe is a bond or -O- and n has a value of |