http://rdf.ncbi.nlm.nih.gov/pubchem/patent/BG-61768-B1
Outgoing Links
| Predicate | Object |
|---|---|
| assignee | http://rdf.ncbi.nlm.nih.gov/pubchem/patentassignee/MD5_05a203d85ee01909eaf728dc16f0f6cb |
| classificationCPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D233-56 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D309-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D231-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/C07D249-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentcpc/A61P43-00 |
| classificationIPCInventive | http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D405-12 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D233-60 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-04 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D309-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4164 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4192 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-4196 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P43-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P37-08 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-35 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-40 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61K31-415 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P9-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/A61P29-00 http://rdf.ncbi.nlm.nih.gov/pubchem/patentipc/C07D521-00 |
| filingDate | 1995-10-18^^<http://www.w3.org/2001/XMLSchema#date> |
| inventor | http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_c6e5f4aebe63347ce36817d9a03eccbf http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_4261146e4848054b10bd08cd68ece365 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_eb568b0ef468eb9db887f4904917f5f7 http://rdf.ncbi.nlm.nih.gov/pubchem/patentinventor/MD5_aacc79a3f1231e7100f6b89dd2720a9a |
| publicationDate | 1998-05-29^^<http://www.w3.org/2001/XMLSchema#date> |
| publicationNumber | BG-61768-B1 |
| titleOfInvention | 5-LYOXYGENASE INHIBITORS |
| abstract | The compounds are appplicable in the treatment ofinflammatory diseases, allergy and cardiovascular impairments inmammals as well as active ingredients in pharmaceuticalcompositions for the treatment of such diseases. The compoundshave the formulawhere: Ar1 is heterocyclic group selected from the group ofimidazolyl, pyrolyl, pyrazolyl, 1,2,3-trazolyl, 1,2,4-triazolyl,indolyl, indazolyl, benzimidazolyl, which is bound by X1 by a ringnitrogen atom and can optionally be substituted by one or twosubstituents selected of halogen, hydroxy, cyano, amino, C1-4alkyl, C1-4 alkoxy, C1-4 alkylthio, C1-4 halogenosubstitutedalkyl, C1-4 halogensubstituted alkoxy, C1-4 alkylamino and di(C1-4) alkylamino; X1 is direct bond or C1-4 alkylene, Ar2 isphenyl, optionally substituted by one or two substituents selectedof halogen, hydroxy, cyano, amino, C1-4 alkyl, C1-4 alkoxy, C1-4alkylthio, C1-4 halogensubstituted alkyl, C1-4 halogensubstitutedalkoxy; X2 is -A-X- or -X-A-, where A is a direct bond or C1-4alkylene, and X is oxy, thio, suphinyl or sulphonyl; Ar3 isphenylene, pyridilene, thienilene, furilene, oxazolylene orthiazolylene, optionally substituted by one or two substituentsselected of halogen, hydroxy, cyano, amino, C1-4 alkyl, C1-4alkoxy, C1-4 alkylthio, C1-4 halogensubstituted alkyl, C1-4halogen substituted alkoxy, C1-4 alkylamino and di (C1-4)alkylamino; R1 and R2 separately are C1-4 alkyl or together form agroup with the formula -D1-Z-D2-, which, together with the carbonatom to which it is attached, form a ring from 3 to 8 atoms, andD1 and D2 being C1-4 alkylen, Z being direct bond or oxy, thio,sulphinyl or vinylene and D1 and D2 can be substituted by C1-4alkyl; Y is CONR3R4, CN, COOR3, COR3 or CSNR3R4 where each ofradicals R3 and R4 is H or C1-4 alkyl. |
| priorityDate | 1994-10-18^^<http://www.w3.org/2001/XMLSchema#date> |
| type | http://data.epo.org/linked-data/def/patent/Publication |
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