| abstract |
1. A compound of formula EMI3.0 or a pharmaceutically acceptable salt or stereochemically isomer thereof wherein A1 = A2-A3 = A4 represents a bivalent radical of formula -CH = CH-CH = CH- (a-1), -N = CH- - (a-2), -CH = N-CH = CH- (a-3), -CH = CH- N = CH- (a-4) ), -N = CH-N = CH- (a-6) or -CH = N-CH = N- (a-7), as one or two hydrogen atoms in the radicals listed in (a- 1) -7) may each be substituted with halo, C 1-6 alkyl, C 1-6 alkoxy, hydroxy or trifluoromethyl; R represents hydrogen atoms of C1-4 alkyl; R 1 is hydrogen, C 1-6 alkyl or hydroxy C 1-6 alkyl; m is 1 or 2; D represents C 1-4 alkanediyl; B-NR 2, CH 2, O, S, SO or SO 2, wherein R 2 is hydrogen or C 1-4 alkyl; n is 0, 1 or 2; L represents hydrogen, C 1-12 alkyl, C 3-6 cycloalkyl, C 3-6 alkenyl optionally substituted with aryl, C 1-6 alkylcarbonyl, C 1-6 alkyloxycarbonyl, arylcarbonyl, aryl C 1-6 alkoxycarbonyl or a radical of formula Alk-R 3 (b-1), - Alk-Y-R 4 (b-2), - Alk-Z 1 -C (= X) -Z 2 -R 5 (b-3) or -CH 2 -CHOH -CH 2 -O- 4), wherein R3 represents cyano, aryl or Het; R4 is hydrogen, aryl, Het or C1-6 alkyl optionally substituted with aryl or Het; R5 is hydrogen, aryl, Het or C1-6 alkyl optionally substituted with aryl or Het; R6 is aryllyl naphthalenyl; Y is O, S, NR7, wherein R7 is hydrogen, C1-6 alkyl or C1-6 alkylcarbonyl; Z1 and Z2 independently of one another are O, S, NR8 or a direct bond, wherein R8 is hydrogen, C1-6 alkyl, X represents O, S or NR9, wherein R9 is hydrogen, C1-6 alkyl or cyano, each Alk being independently Cl -6alkanediyl, eachHet represents: |