| abstract |
"IMMIDAZOLE COMPOUNDS Fused to Aryl or Heteroaryl as Anti-Inflammatory and Analgesic Agents". This invention provides a compound of formula (I): or pharmaceutically acceptable salts thereof, wherein Y 1, R 2, Y 3, and Y 3 are independently selected from N, CH, etc.. ; R2 is C1-8 alkyl, etc .; Q1 is a 512 membered aromatic monocyclic or bicyclic ring optionally containing up to 4 heteroatoms selected from O, N and S, etc .; A is a 5-6 membered aromatic monocyclic ring, optionally containing up to 3 heteroatoms selected from O, N and S, etc .; B is C 1-6 alkylene optionally substituted with an oxo group, etc .; W is NH, O, etc. R 2 is H, C 1-4 alkyl, etc .; Z is a 5-12 membered aromatic monocyclic or bicyclic ring, optionally containing up to 3 heteroatoms selected from O, N and S, etc .; L is halo, C 1-4 alkyl, etc .; m is 0, 1 or 2; R 3 and R 4 are independently selected from H and C 1-4 alkyl; R5 is H, C1-4 alkyl, etc .; Q 2 is a 5-12 membered aromatic monocyclic or bicyclic ring, optionally containing up to 3 heteroatoms selected from O, N and S, etc. These compounds are useful for the medical treatment of prostaglandin mediated conditions such as pain, fever or inflammation, etc. This invention also relates to a pharmaceutical composition including the above compound. |