| abstract |
LINK DOMAIN. the presentninvention provides a variant antigen binding domain thatncomprises at least one mutation in the VH domain, compared to anreference antibody, and exhibiting an increased affinity for TRBC2nrelative to the reference antibody. It also provides an antibody, anchimeric antigen receptor (CAR) and a T cell engagern(BiTE), a cell comprising the aforementioned CAR and anconjugate comprising said antigen-binding domainnvariant or said antibody. In addition, it provides medical uses,ndiagnostic methods and personalized medicine methods that explorenthe products of the invention. |