| abstract |
Invention Patent: <B> "SYNTHETIC ANTIPATOGENIC PEPTIDES AND COMPOSITIONS THAT UNDERSTAND THE SAME" <D>. Non-hemolytic cytolytic agents selected from peptides, bundled peptide complexes, mixtures of peptides or random peptide copolymers have selective cytolytic activity, manifested in that they have cytolytic activity on pathogenic cells, being cells that do not occur naturally inside the body, and which consist of microbial pathogenic organisms and malignant cells; and are not hemolytic, having no cytolytic effect on red blood cells. The peptides can be cyclic derivatives of natural peptides, such as pardaxin and melitin and fragments thereof where the L amino acid residues are replaced by corresponding D amino acid residues, or are linear peptide diastereomers composed of varying proportions of at least a positively charged amino acid and at least one hydrophobic amino acid, and in which at least one of the amino acid residues is an D amino acid. Pharmaceutical compositions composed of non-hemolytic cytolytic agents can be used for the treatment of various diseases caused by pathogens, including antibacterial, fungal, viral, mycoplasma and protozoan infections and for the treatment of cancer. |